Application of Genomic Medicine in Africa: 14th Conference of the African Society of Human Genetics and the 2nd International Congress of the Moroccan Society of Genomics and Human Genetics, Rabat, Morocco 2022
Am J Trop Med Hyg. 2024 May 2:tpmd230808. doi: 10.4269/ajtmh.23-0808. Online ahead of print.ABSTRACTThe 14th African Society of Human Genetics (AfSHG) Morocco Meeting and 2nd International Congress of the Moroccan Society of Genomics and Human Genetics (SM2GH), held in Rabat, Morocco, from December 12 through 17, 2022, brought together 298 attendees from 23 countries, organized by the AfSHG in collaboration with the SM2GH. The conference's overarching theme was "Applications of Genomics Medicine in Africa," covering a wide range of topics, including population genetics, genetics of infectious diseases, hereditary disorders...
Source: The American Journal of Tropical Medicine and Hygiene - May 2, 2024 Category: Tropical Medicine Authors: Meryem Fakhkhari Ikram Salih Najwa Maazaz Victoria Nembaware Nchangwi Syntia Munung Alice Matimba Sanaa Chala Ahmed Belmouden Karon Chappell Leon Mutesa Ghada El-Kamah Hicham Oumzil Larbi Baassi Younes Abbas Mohamed Zahir Alimohamed Michele Ramsay Scott W Source Type: research
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma
This study aimed to develop a prognostic signature of bilirubin metabolism-associated genes (BMAGs) to predict outcomes and efficacy of immunotherapy in LUAD. We analysed gene expression data from The Cancer Genome Atlas (TCGA) to identify survival-related BMAGs and construct a prognostic model in LUAD. The prognostic efficacy of our model was corroborated by employing TCGA-LUAD and five Gene Expression Omnibus datasets, effectively stratifying patients into risk-defined cohorts with marked disparities in survival. The BMAG signature was indeed an independent prognostic determinant, outperforming established clinical param...
Source: Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Kangqi Ren Xiean Ling Lin Chen Zeyao Li Tonghai Huang Source Type: research
Cascade-Targeted Nanoplatforms for Synergetic Antibiotic/ROS/NO/Immunotherapy against Intracellular Bacterial Infection
Biomacromolecules. 2024 May 1. doi: 10.1021/acs.biomac.4c00339. Online ahead of print.ABSTRACTIntracellular bacteria in dormant states can escape the immune response and tolerate high-dose antibiotic treatment, leading to severe infections. To overcome this challenge, cascade-targeted nanoplatforms that can target macrophages and intracellular bacteria, exhibiting synergetic antibiotic/reactive oxygen species (ROS)/nitric oxide (NO)/immunotherapy, were developed. These nanoplatforms were fabricated by encapsulating trehalose (Tr) and vancomycin (Van) into phosphatidylserine (PS)-coated poly[(4-allylcarbamoylphenylboric aci...
Source: Biomacromolecules - May 2, 2024 Category: Biochemistry Authors: Xiaomei Dai Xiaojun Liu Xingxing Wang Yongjie Zhang Yu Li Feng Gao Source Type: research
Very unusual extremely high ferritin with cytokine release syndrome in a patient with hematological malignancy after experimental chimeric antigen receptor (CAR)-T-Cell therapy
CONCLUSIONS: Cytokine release syndrome after experimental (CAR) T cell therapy may cause extremely elevated ferritin and hemophagocytic lymphohistiocytosis -like syndrome.PMID:38697457 | DOI:10.1016/j.cca.2024.119704 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - May 2, 2024 Category: Chemistry Authors: Robert Hoyt Zhan Ye Amitava Dasgupta Source Type: research
Extracellular Vesicles-powered Immunotherapy: Unleashing the Potential for Safer and More Effective Cancer Treatment
This article discusses the importance of integrating nanomedicines into OIMTs, highlighting the challenges with current anti-OIMT methods. It also explores key considerations for designing nanomedicines tailored for OIMTs, aiming to improve upon existing immunotherapy techniques. Additionally, the article looks into innovative approaches like biomimicry and the use of natural biomaterial-based nanocarriers (NCs). These advancements have the potential to transform the delivery of immunotherapy. Lastly, the article addresses the challenges of moving OIMTs from theory to clinical practice, providing insights into the future o...
Source: Archives of Biochemistry and Biophysics - May 2, 2024 Category: Biochemistry Authors: Pratiksha Tiwari Krishna Yadav Ravi Prakash Shukla Avijit Kumar Bakshi Dilip Panwar Sweety Das Prabhat Ranjan Mishra Source Type: research
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma
This study aimed to develop a prognostic signature of bilirubin metabolism-associated genes (BMAGs) to predict outcomes and efficacy of immunotherapy in LUAD. We analysed gene expression data from The Cancer Genome Atlas (TCGA) to identify survival-related BMAGs and construct a prognostic model in LUAD. The prognostic efficacy of our model was corroborated by employing TCGA-LUAD and five Gene Expression Omnibus datasets, effectively stratifying patients into risk-defined cohorts with marked disparities in survival. The BMAG signature was indeed an independent prognostic determinant, outperforming established clinical param...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Kangqi Ren Xiean Ling Lin Chen Zeyao Li Tonghai Huang Source Type: research
Clinical outcomes associated with neoadjuvant therapy for the treatment of resectable non-small cell lung cancer in real-world practice
CONCLUSIONS: Neoadjuvant treatment with a combination of immunotherapy plus chemotherapy appears to achieve higher radiological and pathological responses than monotherapy for IIA-IIIB NSCLC. Log-rank analysis showed that a better outcome could be expected in patients with the addition of immunotherapy to neoadjuvant chemotherapy if compared with patients with chemotherapy alone in terms of DFS.PMID:38693705 | DOI:10.1111/crj.13761 (Source: Respiratory Care)
Source: Respiratory Care - May 2, 2024 Category: Respiratory Medicine Authors: Xiaojie Huang Guanchao Pang Zhirong Mao Baizhou Li Zhihua Teng Yan Yang Zijian Qiu Xiuxiu Chen Pingli Wang Source Type: research
Clinical outcomes associated with neoadjuvant therapy for the treatment of resectable non-small cell lung cancer in real-world practice
CONCLUSIONS: Neoadjuvant treatment with a combination of immunotherapy plus chemotherapy appears to achieve higher radiological and pathological responses than monotherapy for IIA-IIIB NSCLC. Log-rank analysis showed that a better outcome could be expected in patients with the addition of immunotherapy to neoadjuvant chemotherapy if compared with patients with chemotherapy alone in terms of DFS.PMID:38693705 | DOI:10.1111/crj.13761 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 2, 2024 Category: Cancer & Oncology Authors: Xiaojie Huang Guanchao Pang Zhirong Mao Baizhou Li Zhihua Teng Yan Yang Zijian Qiu Xiuxiu Chen Pingli Wang Source Type: research
Super giant basal cell carcinoma: a comprehensive systematic review
Ann Med Surg (Lond). 2024 Mar 19;86(5):2935-2939. doi: 10.1097/MS9.0000000000001958. eCollection 2024 May.ABSTRACTSuper giant basal cell carcinoma (SGBCC), defined as greater than 20 cm in diameter, is a rare oncological entity, with scarce literature. The authors conducted a review to characterize SGBCC, specifically with regards to age, sex predilection, risk factors, geographical location, body site, metastasis, and treatment. A systematic literature search was conducted from 1972 to 2023. All abstracts, studies, and citations were reviewed. The initial result showed 47 281 articles and were filtered down for human, ski...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Ajaipal S Kang Genelia Kang Harjaap S Kathuria Source Type: research
Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment
ACS Nano. 2024 May 1. doi: 10.1021/acsnano.4c02265. Online ahead of print.ABSTRACTCancer, as one of the leading causes of death worldwide, drives the advancement of cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge as promising therapeutic nanodrugs that provide a reference for cancer therapy. In this review, we present recent breakthrough nanozymes for cancer treatment. First, we comprehensively outline the preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal method, chemical reduction method, biomimetic mineralizati...
Source: Cancer Control - May 2, 2024 Category: Cancer & Oncology Authors: Qinrui Fu Chuang Wei Mengzhen Wang Source Type: research
Clinical outcomes associated with neoadjuvant therapy for the treatment of resectable non ‐small cell lung cancer in real‐world practice
ConclusionsNeoadjuvant treatment with a combination of immunotherapy plus chemotherapy appears to achieve higher radiological and pathological responses than monotherapy for IIA-IIIB NSCLC. Log-rank analysis showed that a better outcome could be expected in patients with the addition of immunotherapy to neoadjuvant chemotherapy if compared with patients with chemotherapy alone in terms of DFS. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 2, 2024 Category: Respiratory Medicine Authors: Xiaojie Huang,
Guanchao Pang,
Zhirong Mao,
Baizhou Li,
Zhihua Teng,
Yan Yang,
Zijian Qiu,
Xiuxiu Chen,
Pingli Wang Tags: ORIGINAL ARTICLE Source Type: research
Cancer Nanovaccines: Nanomaterials and Clinical Perspectives
This review provides detailed insight into cancer nanovaccines. It examines current developments, innovative strategies, and technologies, encompassing preclinical/clinical advancements. Key focuses include antigen/adjuvant selection, biomaterial-based delivery, and the impact of nanoscale properties on vaccine performance. It also discusses the interplay between the tumor microenvironment and nanovaccine responses alongside ongoing clinical trials, aiming to guide researchers/clinicians in optimizing therapeutic outcomes. AbstractCancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotec...
Source: Small - May 2, 2024 Category: Nanotechnology Authors: Nimeet Desai,
Vivek Chavda,
Thakur Raghu Raj Singh,
Nanasaheb D. Thorat,
Lalitkumar K. Vora Tags: Review Source Type: research
Treating moderate-to-severe atopic dermatitis with benralizumab: results from the HILLIER study, a plain language summary
Immunotherapy, Ahead of Print. (Source: Immunotherapy)
Source: Immunotherapy - May 2, 2024 Category: Allergy & Immunology Authors: Emma Guttman-Yassky Lila Bahadori Laura Brooks Ken L Clark Hanna Grindebacke Calvin N Ho Rohit Katial Tuyet-Hang Pham Claire Walton Catherine J Datto Source Type: research
Neoadjuvante Immuntherapie bei Kopf-Hals-
PlattenepithelkarzinomenNeoadjuvant immunotherapy for head and neck squamous cell
carcinoma
Laryngorhinootologie 2024; 103: S167-S187 DOI: 10.1055/a-2183-5802Das Konzept der neoadjuvanten Immuntherapie stellt einen bedeutenden
Paradigmenwechsel bei der Behandlung von potenziell heilbaren
Kopf-Hals-Plattenepithelkarzinomen (HNSCC, head and neck squamous cell
carcinoma) dar. Die derzeitigen Therapien sind zwar hochgradig individualisiert
und innovativ, erreichen aber oft keine zufriedenstellenden
Langzeitüberlebensraten und sind häufig mit einer erheblichen Morbidität
verbunden.Der Hauptvorteil dieses Ansatzes liegt in dem Potenzial, die Therapie mit ei...
Source: Laryngo- Rhino- Otologie - May 2, 2024 Category: ENT & OMF Authors: K ürten, Cornelius H. L. Ferris, Robert L. Tags: Referat Source Type: research
Treatment resistance in inclusion body myositis: the role of mast cells
Inclusion body myositis (IBM) has a characteristic clinical presentation consisting of progressive asymmetric finger flexion and knee extension weakness. Currently, it is classified as an idiopathic inflammatory myopathy (IIM) despite significant clinical differences to other IIMs, including a lack of response to conventional immunotherapies [1]. One suggested explanation for this is the presence of highly differentiated cytotoxic T-cells in IBM [2]. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - May 2, 2024 Category: Neurology Authors: I Acosta, M Hofer, D Hilton-Jones, W Squier, S Brady Tags: Short communication Source Type: research
