Targeted pH-Activated Peptide-Based Nanomaterials for Combined Photodynamic Therapy with Immunotherapy
In this study, we developed pH-responsive porphyrin-peptide nanosheets with tumor-targeting capabilities (PRGD) that were loaded with the IDO inhibitor NLG919 for a dual application involving PDT and immunotherapy (PRGD/NLG919). In vitro experiments revealed the heightened cellular uptake of PRGD/NLG919 nanosheets in tumor cells overexpressing αvβ3 integrins. The pH-responsive PRGD/NLG919 nanosheets demonstrated remarkable singlet oxygen generation and photocytotoxicity in HeLa cells in an acidic tumor microenvironment. When treating HeLa cells with PRGD/NLG919 nanosheets followed by laser irradiation, a more robust adap...
Source: Biomacromolecules - April 25, 2024 Category: Biochemistry Authors: Bingbing Sun Haowen Yang Yudong Li Jari F Scheerstra Marleen H M E van Stevendaal Shukun Li Jan C M van Hest Source Type: research
Supramolecular Assembly and Thermogelation Strategies Using Peptide-Polymer Conjugates
Biomacromolecules. 2024 Apr 25. doi: 10.1021/acs.biomac.4c00031. Online ahead of print.ABSTRACTPeptide-polymer conjugates (PPCs) are of particular interest in the development of responsive, adaptive, and interactive materials due to the benefits offered by combining both building blocks and components. This review presents pioneering work as well as recent advances in the design of peptide-polymer conjugates, with a specific focus on their thermoresponsive behavior. This unique class of materials has shown great promise in the development of supramolecular structures with physicochemical properties that are modulated using...
Source: Biomacromolecules - April 25, 2024 Category: Biochemistry Authors: Chlo é Pascouau Maren Schweitzer Pol Besenius Source Type: research
A Review of Current Achievements and Recent Challenges in Bacterial Medium-Chain-Length Polyhydroxyalkanoates: Production and Potential Applications
In conclusion, this review serves as a valuable resource to understand mcl-PHAs as sustainable alternatives to conventional plastics. However, further research is needed to optimize production methods, evaluate long-term ecological impacts, and assess the feasibility and viability in various industries.PMID:38656151 | DOI:10.1021/acs.biomac.4c00090 (Source: Biomacromolecules)
Source: Biomacromolecules - April 24, 2024 Category: Biochemistry Authors: Nahid Azizi Reza Eslami Shaghayegh Goudarzi Habibollah Younesi Hadis Zarrin Source Type: research
A Review of Current Achievements and Recent Challenges in Bacterial Medium-Chain-Length Polyhydroxyalkanoates: Production and Potential Applications
In conclusion, this review serves as a valuable resource to understand mcl-PHAs as sustainable alternatives to conventional plastics. However, further research is needed to optimize production methods, evaluate long-term ecological impacts, and assess the feasibility and viability in various industries.PMID:38656151 | DOI:10.1021/acs.biomac.4c00090 (Source: Biomacromolecules)
Source: Biomacromolecules - April 24, 2024 Category: Biochemistry Authors: Nahid Azizi Reza Eslami Shaghayegh Goudarzi Habibollah Younesi Hadis Zarrin Source Type: research
Enzyme-Triggered Polyelectrolyte Complex for Responsive Delivery of α-Helical Polypeptides to Optimize Antibacterial Therapy
In this study, we present an enzyme-responsive polyelectrolyte complex micelles (PTPMN) with α-helical cationic polypeptide as a coacervate-core for the treatment of Escherichia coli (E. coli) infection. The complex was constructed through electrostatic interaction between cationic poly(glutamic acid) derivatives and phosphorylation-modified poly(ethylene glycol)-b-poly(tyrosine) (PEG-b-PPTyr) by directly dissolving them in aqueous solution. The cationic polypeptide adopted α-helical structure and demonstrated excellent broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria, with a mi...
Source: Biomacromolecules - April 23, 2024 Category: Biochemistry Authors: Liuxuan Li Ruoxue Wang Bo Zhao Bowen Yin Huijuan Zhang Chunyong Liang Xiuli Hu Source Type: research
Divergent Polymer Superstructures from Protonated Poly(adenine) DNA and RNA
Biomacromolecules. 2024 Apr 23. doi: 10.1021/acs.biomac.4c00271. Online ahead of print.ABSTRACTStudies have shown that poly(adenine) DNA and RNA strands protonate at a low pH to form self-associating duplexes; however, the nanoscopic morphology of these structures is unclear. Here, we use Transition Electron Microscopy (TEM), Atomic Force Microscopy (AFM), dynamic light scattering (DLS), and fluorescence spectroscopy to show that both ribose identity (DNA or RNA) and assembly conditions (thermal or room-temperature annealing) dictate unique hierarchical structures for poly(adenine) sequences at a low pH. We show that while...
Source: Biomacromolecules - April 23, 2024 Category: Biochemistry Authors: Lachlan Cox Changzhuang Bai Casey M Platnich Felix J Rizzuto Source Type: research
Multiscale Simulations of Self-Assembling Peptides: Surface and Core Hydrophobicity Determine Fibril Stability and Amyloid Aggregation
Biomacromolecules. 2024 Apr 23. doi: 10.1021/acs.biomac.4c00151. Online ahead of print.ABSTRACTAssemblies of peptides and proteins through specific intermolecular interactions set the basis for macroscopic materials found in nature. Peptides provide easily tunable hydrogen-bonding interactions, which can lead to the formation of ordered structures such as highly stable β-sheets that can form amyloid-like supramolecular peptide nanofibrils (PNFs). PNFs are of special interest, as they could be considered as mimics of various fibrillar structures found in nature. In their ability to serve as supramolecular scaffolds, they c...
Source: Biomacromolecules - April 23, 2024 Category: Biochemistry Authors: Aysenur Iscen K übra Kaygisiz Christopher V Synatschke Tanja Weil Kurt Kremer Source Type: research
Investigation of Basolateral Targeting Micelles for Drug Delivery Applications in Polycystic Kidney Disease
Biomacromolecules. 2024 Apr 23. doi: 10.1021/acs.biomac.3c01397. Online ahead of print.ABSTRACTAutosomal dominant polycystic kidney disease (ADPKD) is a complex disorder characterized by uncontrolled renal cyst growth, leading to kidney function decline. The multifaceted nature of ADPKD suggests that single-pathway interventions using individual small molecule drugs may not be optimally effective. As such, a strategy encompassing combination therapy that addresses multiple ADPKD-associated signaling pathways could offer synergistic therapeutic results. However, severe off-targeting side effects of small molecule drugs pose...
Source: Biomacromolecules - April 23, 2024 Category: Biochemistry Authors: Yi Huang Ali Osouli Jessica Pham Valeria Mancino Colette O'Grady Taranatee Khan Baishali Chaudhuri Nuria M Pastor-Soler Kenneth R Hallows Eun Ji Chung Source Type: research
Toward Synthetic Intrinsically Disordered Polypeptides (IDPs): Controlled Incorporation of Glycine in the Ring-Opening Polymerization of < em > N < /em > -Carboxyanhydrides
Biomacromolecules. 2024 Apr 23. doi: 10.1021/acs.biomac.4c00142. Online ahead of print.ABSTRACTIntrinsically disordered proteins (IDPs) do not have a well-defined folded structure but instead behave as extended polymer chains in solution. Many IDPs are rich in glycine residues, which create steric barriers to secondary structuring and protein folding. Inspired by this feature, we have studied how the introduction of glycine residues influences the secondary structure of a model polypeptide, poly(l-glutamic acid), a helical polymer. For this purpose, we carried out ring-opening copolymerization with γ-benzyl-l-glutamate an...
Source: Biomacromolecules - April 23, 2024 Category: Biochemistry Authors: Mostafa Badreldin Pedro Salas-Ambrosio Sylvain Bourasseau Sebastien Lecommandoux Simon Harrisson Colin Bonduelle Source Type: research
Injectable Modified Sodium Alginate Microspheres for Enhanced Operative Efficiency and Safety in Endoscopic Submucosal Dissection
Biomacromolecules. 2024 Apr 23. doi: 10.1021/acs.biomac.4c00081. Online ahead of print.ABSTRACTEndoscopic submucosal dissection (ESD) is an effective method for resecting early-stage tumors in the digestive system. To achieve a low injection pressure of the injected fluid and continuous elevation of the mucosa following injection during the ESD technique, we introduced an innovative injectable sodium-alginate-based drug-loaded microsphere (Cipro-ThSA) for ESD surgery, which was generated through an emulsion reaction involving cysteine-modified sodium alginate (ThSA) and ciprofloxacin. Cipro-ThSA microspheres exhibited nota...
Source: Biomacromolecules - April 23, 2024 Category: Biochemistry Authors: Luzhan Huang Yongchao Jiang Pengcheng Zhang Muhan Li Bingrong Liu Keyong Tang Source Type: research
The Effect of Cellulose Nanocrystal Reassembly on Latex-Based Pressure-Sensitive Adhesive Performance
In this study, carboxylated CNCs (cCNCs) were incorporated into a seeded, semibatch, 2-ethylhexyl acrylate/methyl methacrylate/styrene emulsion polymerization and cast as pressure-sensitive adhesive (PSA) films. The addition of CNCs led to a simultaneous increase in tack strength, peel strength, and shear adhesion, avoiding the typical trade-off between the adhesive and cohesive strength. Increased CNC reassembly resulted from the use of dried, redispersed, and sonicated cCNCs, along with increased cCNC loading and addition of the cCNCs at the seed stage of the polymerization. The increased degree of CNC reassembly was sho...
Source: Biomacromolecules - April 22, 2024 Category: Biochemistry Authors: Parisa Bayat Kelly M Meek Maryam Movafagh Emily D Cranston Michael F Cunningham Pascale Champagne Timothy Morse Michael V Kiriakou Sean R George Marc A Dub é Source Type: research
Correction to "Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria"
Biomacromolecules. 2024 Apr 19. doi: 10.1021/acs.biomac.4c00501. Online ahead of print.NO ABSTRACTPMID:38640499 | DOI:10.1021/acs.biomac.4c00501 (Source: Biomacromolecules)
Source: Biomacromolecules - April 19, 2024 Category: Biochemistry Authors: Tanvi Jakkampudi Qiao Lin Saheli Mitra Aishwarya Vijai Weiheng Qin Ann Kang Jespar Chen Emma Ryan Runxuan Wang Yuqi Gong Frank Heinrich Junming Song Yuan-Pu Peter Di Stephanie Tristram-Nagle Source Type: research
Multifunctional Self-Healing Carbon Dot-Gelatin Bioadhesive: Improved Tissue Adhesion with Simultaneous Drug Delivery, Optical Tracking, and Photoactivated Sterilization
Biomacromolecules. 2024 Apr 17. doi: 10.1021/acs.biomac.4c00313. Online ahead of print.ABSTRACTBioadhesives with all-inclusive properties for simultaneous strong and robust adhesion, cohesion, tracking, drug delivery, self-sterilization, and nontoxicity are still farfetched. Herein, a carbon dot (CD) is made to infuse each of the above-desired aspects with gelatin, an inexpensive edible protein. The CD derived through controlled hydrothermal pyrolysis of dopamine and terephthaldehyde retained -NH2, -OH, -COOH, and, most importantly, -CHO functionality on the CD surface for efficient skin adhesion and cross-linking. Facile ...
Source: Biomacromolecules - April 18, 2024 Category: Biochemistry Authors: Maansi Aggarwal Harekrishna Panigrahi Dinesh Kumar Kotnees Prolay Das Source Type: research
Beyond the Surface: A Methodological Exploration of Enzyme Impact along the Cellulose Fiber Cross-Section
Biomacromolecules. 2024 Apr 18. doi: 10.1021/acs.biomac.4c00152. Online ahead of print.ABSTRACTDespite the wide range of analytical tools available for the characterization of cellulose, the in-depth characterization of inhomogeneous, layered cellulose fiber structures remains a challenge. When treating fibers or spinning man-made fibers, the question always arises as to whether the changes in the fiber structure affect only the surface or the entire fiber. Here, we developed an analysis tool based on the sequential limited dissolution of cellulose fiber layers. The method can reveal potential differences in fiber properti...
Source: Biomacromolecules - April 18, 2024 Category: Biochemistry Authors: Irina Sulaeva Fredrik Gjerstad Sto Pamo Ivan Melikhov David Budischowsky Jenni L Rahikainen Anna Borisova Kaisa Marjamaa Kristiina Kruus Vincent G H Eijsink Anik ó Várnai Antje Potthast Source Type: research
Multifunctional Self-Healing Carbon Dot-Gelatin Bioadhesive: Improved Tissue Adhesion with Simultaneous Drug Delivery, Optical Tracking, and Photoactivated Sterilization
Biomacromolecules. 2024 Apr 17. doi: 10.1021/acs.biomac.4c00313. Online ahead of print.ABSTRACTBioadhesives with all-inclusive properties for simultaneous strong and robust adhesion, cohesion, tracking, drug delivery, self-sterilization, and nontoxicity are still farfetched. Herein, a carbon dot (CD) is made to infuse each of the above-desired aspects with gelatin, an inexpensive edible protein. The CD derived through controlled hydrothermal pyrolysis of dopamine and terephthaldehyde retained -NH2, -OH, -COOH, and, most importantly, -CHO functionality on the CD surface for efficient skin adhesion and cross-linking. Facile ...
Source: Biomacromolecules - April 18, 2024 Category: Biochemistry Authors: Maansi Aggarwal Harekrishna Panigrahi Dinesh Kumar Kotnees Prolay Das Source Type: research
