Pro-vasculogenic Fibers by PDA-Mediated Surface Functionalization Using Cell-Free Fat Extract (CEFFE)
This study highlights the potential of currently engineered pro-vasculogenic fibers as a versatile platform for engineering vascularized biomaterial constructs for functional tissue regeneration.PMID:38411008 | DOI:10.1021/acs.biomac.3c01124 (Source: Biomacromolecules)
Source: Biomacromolecules - February 27, 2024 Category: Biochemistry Authors: Donghong Li Qinglin Li Tingting Xu Xuran Guo Han Tang Wenbo Wang Wenjie Zhang Yanzhong Zhang Source Type: research
Advanced Hollow Cathode Discharge Plasma Treatment of Unique Bilayered Fibrous Nerve Guidance Conduits for Enhanced/Oriented Neurite Outgrowth
Biomacromolecules. 2024 Feb 27. doi: 10.1021/acs.biomac.3c00976. Online ahead of print.ABSTRACTDespite all recent progresses in nerve tissue engineering, critical-sized nerve defects are still extremely challenging to repair. Therefore, this study targets the bridging of critical nerve defects and promoting an oriented neuronal outgrowth by engineering innovative nerve guidance conduits (NGCs) synergistically possessing exclusive topographical, chemical, and mechanical cues. To do so, a mechanically adequate mixture of polycaprolactone (PCL) and polylactic-co-glycolic acid (PLGA) was first carefully selected as base materi...
Source: Biomacromolecules - February 27, 2024 Category: Biochemistry Authors: Sheida Aliakbarshirazi Rouba Ghobeira Mahtab Asadian Mehrnoush Narimisa Anton Nikiforov Ives De Baere Wim Van Paepegem Nathalie De Geyter Heidi Declercq Rino Morent Source Type: research
Structural Consequences of Introducing Bioactive Domains to Designer β-Sheet Peptide Self-Assemblies
Biomacromolecules. 2024 Feb 26. doi: 10.1021/acs.biomac.3c00962. Online ahead of print.ABSTRACTWe applied solid- and solution-state nuclear magnetic resonance spectroscopy to examine the structure of multidomain peptides composed of self-assembling β-sheet domains linked to bioactive domains. Bioactive domains can be selected to stimulate specific biological responses (e.g., via receptor binding), while the β-sheets provide the desirable nanoscale properties. Although previous work has established the efficacy of multidomain peptides, molecular-level characterization is lacking. The bioactive domains are intended to rema...
Source: Biomacromolecules - February 26, 2024 Category: Biochemistry Authors: Alicia S Robang Abhishek Roy Joseph B Dodd-O Dongjing He Justin V Le Andrew C McShan Yuhang Hu Vivek A Kumar Anant K Paravastu Source Type: research
Enzymatic Synthesis of α-Glucan Microparticles Using Amylosucrases from < em > Bifidobacterium < /em > Species and Its Physicochemical Properties
This study proposes a bottom-up approach for producing GMPs using four amylosucrases from Bifidobacterium sp. (BASs). The physicochemical characteristics of these GMPs were analyzed, and the results showed that the properties of the GMPs varied depending on the type of enzymes used in their synthesis. As common properties, all GMPs exhibited typical B-type crystal patterns and poor colloidal dispersion stability. Interestingly, differences in the physicochemical properties of GMPs were generated depending on the synthesis rate of linear α-glucan by the enzymes and the degree of polymerization (DP) distribution. Consequent...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Ye-Jin Kim Yun-Sang So Moo-Yeol Baik Young-Rok Kim Sang-Ho Yoo Dong-Ho Seo Cheon-Seok Park Source Type: research
Water and Oxygen Barrier Properties of All-Cellulose Nanocomposites
Biomacromolecules. 2024 Feb 23. doi: 10.1021/acs.biomac.3c01337. Online ahead of print.ABSTRACTHydroxypropyl cellulose (HPC) is potentially interesting as a biobased, rigid food packaging material, but its stiffness and strength are somewhat low, and its water and oxygen transport rates are too high. To improve these characteristics, we investigated nanocomposites of HPC and cellulose nanocrystals (CNCs). These high-aspect-ratio nanoparticles display high stiffness and strength, and their high crystallinity renders them virtually impermeable. Exchanging the counterions of sulfate-ester decorated CNCs with cetyltrimethylamm...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Chris Rader Luca Grillo Christoph Weder Source Type: research
Insight into the Feasibility of Fatty Acyl Chlorides with 10-18 Carbons for the Ball-Milling Synthesis of Thermoplastic Cellulose Esters
This study provides some theoretical basis for the mechanochemical synthesis of thermoplastic FACE with designated properties.PMID:38394470 | DOI:10.1021/acs.biomac.3c01354 (Source: Biomacromolecules)
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: De-Fa Hou Pei-Yao Li Kai Zhang Meng-Lei Li Zi-Wei Feng Cong Yan Can Liu Ming-Bo Yang Source Type: research
Aptamer-Targeted Dendrimersomes Assembled from Azido-Modified Janus Dendrimers "Clicked" to DNA
Biomacromolecules. 2024 Feb 23. doi: 10.1021/acs.biomac.3c01108. Online ahead of print.ABSTRACTAmphiphilic Janus dendrimers (JDs), synthetic alternatives to lipids, have the potential to expand the scope of nanocarrier delivery systems. JDs self-assemble into vesicles called dendrimersomes, encapsulate both hydrophobic cargo and nucleic acids, and demonstrate enhanced stability in comparison to lipid nanoparticles (LNPs). Here, we report the ability to enhance the cellular uptake of Janus dendrimersomes using DNA aptamers. Azido-modified JDs were synthesized and conjugated to alkyne-modified DNAs using copper-catalyzed azi...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Paige Bristow Kyle Schantz Zoe Moosbrugger Kailey Martin Haley Liebenberg Stefan Steimle Qi Xiao Virgil Percec Samantha E Wilner Source Type: research
Enzymatic Synthesis of α-Glucan Microparticles Using Amylosucrases from < em > Bifidobacterium < /em > Species and Its Physicochemical Properties
This study proposes a bottom-up approach for producing GMPs using four amylosucrases from Bifidobacterium sp. (BASs). The physicochemical characteristics of these GMPs were analyzed, and the results showed that the properties of the GMPs varied depending on the type of enzymes used in their synthesis. As common properties, all GMPs exhibited typical B-type crystal patterns and poor colloidal dispersion stability. Interestingly, differences in the physicochemical properties of GMPs were generated depending on the synthesis rate of linear α-glucan by the enzymes and the degree of polymerization (DP) distribution. Consequent...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Ye-Jin Kim Yun-Sang So Moo-Yeol Baik Young-Rok Kim Sang-Ho Yoo Dong-Ho Seo Cheon-Seok Park Source Type: research
Water and Oxygen Barrier Properties of All-Cellulose Nanocomposites
Biomacromolecules. 2024 Feb 23. doi: 10.1021/acs.biomac.3c01337. Online ahead of print.ABSTRACTHydroxypropyl cellulose (HPC) is potentially interesting as a biobased, rigid food packaging material, but its stiffness and strength are somewhat low, and its water and oxygen transport rates are too high. To improve these characteristics, we investigated nanocomposites of HPC and cellulose nanocrystals (CNCs). These high-aspect-ratio nanoparticles display high stiffness and strength, and their high crystallinity renders them virtually impermeable. Exchanging the counterions of sulfate-ester decorated CNCs with cetyltrimethylamm...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Chris Rader Luca Grillo Christoph Weder Source Type: research
Insight into the Feasibility of Fatty Acyl Chlorides with 10-18 Carbons for the Ball-Milling Synthesis of Thermoplastic Cellulose Esters
This study provides some theoretical basis for the mechanochemical synthesis of thermoplastic FACE with designated properties.PMID:38394470 | DOI:10.1021/acs.biomac.3c01354 (Source: Biomacromolecules)
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: De-Fa Hou Pei-Yao Li Kai Zhang Meng-Lei Li Zi-Wei Feng Cong Yan Can Liu Ming-Bo Yang Source Type: research
Aptamer-Targeted Dendrimersomes Assembled from Azido-Modified Janus Dendrimers "Clicked" to DNA
Biomacromolecules. 2024 Feb 23. doi: 10.1021/acs.biomac.3c01108. Online ahead of print.ABSTRACTAmphiphilic Janus dendrimers (JDs), synthetic alternatives to lipids, have the potential to expand the scope of nanocarrier delivery systems. JDs self-assemble into vesicles called dendrimersomes, encapsulate both hydrophobic cargo and nucleic acids, and demonstrate enhanced stability in comparison to lipid nanoparticles (LNPs). Here, we report the ability to enhance the cellular uptake of Janus dendrimersomes using DNA aptamers. Azido-modified JDs were synthesized and conjugated to alkyne-modified DNAs using copper-catalyzed azi...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Paige Bristow Kyle Schantz Zoe Moosbrugger Kailey Martin Haley Liebenberg Stefan Steimle Qi Xiao Virgil Percec Samantha E Wilner Source Type: research
Enzymatic Synthesis of α-Glucan Microparticles Using Amylosucrases from < em > Bifidobacterium < /em > Species and Its Physicochemical Properties
This study proposes a bottom-up approach for producing GMPs using four amylosucrases from Bifidobacterium sp. (BASs). The physicochemical characteristics of these GMPs were analyzed, and the results showed that the properties of the GMPs varied depending on the type of enzymes used in their synthesis. As common properties, all GMPs exhibited typical B-type crystal patterns and poor colloidal dispersion stability. Interestingly, differences in the physicochemical properties of GMPs were generated depending on the synthesis rate of linear α-glucan by the enzymes and the degree of polymerization (DP) distribution. Consequent...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Ye-Jin Kim Yun-Sang So Moo-Yeol Baik Young-Rok Kim Sang-Ho Yoo Dong-Ho Seo Cheon-Seok Park Source Type: research
Water and Oxygen Barrier Properties of All-Cellulose Nanocomposites
Biomacromolecules. 2024 Feb 23. doi: 10.1021/acs.biomac.3c01337. Online ahead of print.ABSTRACTHydroxypropyl cellulose (HPC) is potentially interesting as a biobased, rigid food packaging material, but its stiffness and strength are somewhat low, and its water and oxygen transport rates are too high. To improve these characteristics, we investigated nanocomposites of HPC and cellulose nanocrystals (CNCs). These high-aspect-ratio nanoparticles display high stiffness and strength, and their high crystallinity renders them virtually impermeable. Exchanging the counterions of sulfate-ester decorated CNCs with cetyltrimethylamm...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Chris Rader Luca Grillo Christoph Weder Source Type: research
Insight into the Feasibility of Fatty Acyl Chlorides with 10-18 Carbons for the Ball-Milling Synthesis of Thermoplastic Cellulose Esters
This study provides some theoretical basis for the mechanochemical synthesis of thermoplastic FACE with designated properties.PMID:38394470 | DOI:10.1021/acs.biomac.3c01354 (Source: Biomacromolecules)
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: De-Fa Hou Pei-Yao Li Kai Zhang Meng-Lei Li Zi-Wei Feng Cong Yan Can Liu Ming-Bo Yang Source Type: research
Aptamer-Targeted Dendrimersomes Assembled from Azido-Modified Janus Dendrimers "Clicked" to DNA
Biomacromolecules. 2024 Feb 23. doi: 10.1021/acs.biomac.3c01108. Online ahead of print.ABSTRACTAmphiphilic Janus dendrimers (JDs), synthetic alternatives to lipids, have the potential to expand the scope of nanocarrier delivery systems. JDs self-assemble into vesicles called dendrimersomes, encapsulate both hydrophobic cargo and nucleic acids, and demonstrate enhanced stability in comparison to lipid nanoparticles (LNPs). Here, we report the ability to enhance the cellular uptake of Janus dendrimersomes using DNA aptamers. Azido-modified JDs were synthesized and conjugated to alkyne-modified DNAs using copper-catalyzed azi...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Paige Bristow Kyle Schantz Zoe Moosbrugger Kailey Martin Haley Liebenberg Stefan Steimle Qi Xiao Virgil Percec Samantha E Wilner Source Type: research
