A Biodegradable Janus Sponge for Negative Pressure Wound Therapy
Biomacromolecules. 2024 Mar 28. doi: 10.1021/acs.biomac.4c00046. Online ahead of print.ABSTRACTNegative pressure wound therapy (NPWT) is effective in repairing serious skin injury. The dressing used in the NPWT is important for wound healing. In this paper, we develop biodegradable amphiphilic polyurethanes (PUs) and fabricate the PUs into sponges as wound dressings (Bi@e) with Janus pore architectures for NPWT. The Bi@e is adaptive to all the stages of the wound healing process. The Janus Bi@e sponge consists of two layers: the dense hydrophobic upper layer with small pores provides protection and support during negative ...
Source: Biomacromolecules - March 28, 2024 Category: Biochemistry Authors: Lei Tang Zhaoyuan Guo Quan Zhao Xi Fan Yuji Pu Bin He Jianlin Chen Source Type: research
Strongly Adhesive, Self-Healing, Hemostatic Hydrogel for the Repair of Traumatic Brain Injury
Biomacromolecules. 2024 Mar 27. doi: 10.1021/acs.biomac.3c01406. Online ahead of print.ABSTRACTWith wide clinical demands, therapies for traumatic brain injury (TBI) are a major problem in surgical procedures and after major trauma. Due to the difficulty in regeneration of neurons or axons after injury, as well as the inhibition of blood vessel growth by the formation of neural scars, existing treatment measures have limited effectiveness in repairing brain tissue. Herein, the biomultifunctional hydrogels are developed for TBI treatment based on the Schiff base reaction of calcium ion (Ca2+)-cross-linked oxidized sodium al...
Source: Biomacromolecules - March 27, 2024 Category: Biochemistry Authors: Zuoxiang Dong Jihu Zhao Jian Xu Wenshuai Deng Peng Sun Source Type: research
Strongly Adhesive, Self-Healing, Hemostatic Hydrogel for the Repair of Traumatic Brain Injury
Biomacromolecules. 2024 Mar 27. doi: 10.1021/acs.biomac.3c01406. Online ahead of print.ABSTRACTWith wide clinical demands, therapies for traumatic brain injury (TBI) are a major problem in surgical procedures and after major trauma. Due to the difficulty in regeneration of neurons or axons after injury, as well as the inhibition of blood vessel growth by the formation of neural scars, existing treatment measures have limited effectiveness in repairing brain tissue. Herein, the biomultifunctional hydrogels are developed for TBI treatment based on the Schiff base reaction of calcium ion (Ca2+)-cross-linked oxidized sodium al...
Source: Biomacromolecules - March 27, 2024 Category: Biochemistry Authors: Zuoxiang Dong Jihu Zhao Jian Xu Wenshuai Deng Peng Sun Source Type: research
Functional Polyphenol-Based Nanoparticles Boosted the Neuroprotective Effect of Riluzole for Acute Spinal Cord Injury
Biomacromolecules. 2024 Mar 26. doi: 10.1021/acs.biomac.4c00173. Online ahead of print.ABSTRACTRiluzole is commonly used as a neuroprotective agent for treating traumatic spinal cord injury (SCI), which works by blocking the influx of sodium and calcium ions and reducing glutamate activity. However, its clinical application is limited because of its poor solubility, short half-life, potential organ toxicity, and insufficient bioabilities toward upregulated inflammation and oxidative stress levels. To address this issue, epigallocatechin gallate (EGCG), a natural polyphenol, was employed to fabricate nanoparticles (NPs) wit...
Source: Biomacromolecules - March 26, 2024 Category: Biochemistry Authors: Taoyang Yuan Tianyou Wang Jianhua Zhang Feng Ye Zhipeng Gu Yiwen Li Jianguo Xu Source Type: research
Advances in Polysaccharides for Cartilage Tissue Engineering Repair: A Review
Biomacromolecules. 2024 Mar 24. doi: 10.1021/acs.biomac.3c01424. Online ahead of print.ABSTRACTCartilage repair has been a significant challenge in orthopedics that has not yet been fully resolved. Due to the absence of blood vessels and the almost cell-free nature of mature cartilage tissue, the limited ability to repair cartilage has resulted in significant socioeconomic pressures. Polysaccharide materials have recently been widely used for cartilage tissue repair due to their excellent cell loading, biocompatibility, and chemical modifiability. They also provide a suitable microenvironment for cartilage repair and regen...
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Heng An Meng Zhang Zhen Gu Xiangyu Jiao Yinglei Ma Zhe Huang Yongqiang Wen Yaozhong Dong Peixun Zhang Source Type: research
Correction to "Fibrin-Dextran Hydrogels with Tunable Porosity and Mechanical Properties"
Biomacromolecules. 2024 Mar 25. doi: 10.1021/acs.biomac.4c00276. Online ahead of print.NO ABSTRACTPMID:38525496 | DOI:10.1021/acs.biomac.4c00276 (Source: Biomacromolecules)
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Shannon Anna Jung Hanna Malyaran Dan Eugen Demco Anna Manukanc Leonie Sophie H äser Vytautas Ku čikas Marc van Zandvoort Sabine Neuss Andrij Pich Source Type: research
Versatile Triblock Peptide Self-Assembly System to Mimic Collagen Structure and Function
Biomacromolecules. 2024 Mar 25. doi: 10.1021/acs.biomac.4c00033. Online ahead of print.ABSTRACTThe construction of collagen mimetic peptides has been a hot topic in tissue engineering due to their attractive advantages, such as virus-free nature and low immunogenicity. However, all of the reported self-assembled peptides rely on the inclusion of risky elements of potential safety concerns or lack the capability of incorporating critical functional motifs. A versatile self-assembly design of pure synthetic peptides that can mimic the collagen structure and function remains an insurmountably challenging target. We have herei...
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Linyan Yao Biyang Ling Wenjie Huang Shuangni Shi Jianxi Xiao Source Type: research
Naturally Derived Injectable Dual-Cross-Linked Adhesive Hydrogel for Acute Hemorrhage Control and Wound Healing
Biomacromolecules. 2024 Mar 25. doi: 10.1021/acs.biomac.4c00105. Online ahead of print.ABSTRACTDeveloping biocompatible injectable hydrogels with high mechanical strength and rapid strong tissue adhesion for hemostatic sealing of uncontrolled bleeding remains a prevailing challenge. Herein, we engineer an injectable and photo-cross-linkable hydrogel based on naturally derived gelatin methacrylate (GelMA) and N-hydroxysuccinimide-modified poly(γ-glutamic acid) (γPGA-NHS). The chemically dual-cross-linked hydrogel rapidly forms after UV light irradiation and covalently bonds to the underlying tissue to provide robust adhes...
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Ziran Zhu Huijun Ye Kaiwen Zhang Gang He Zheng Pan Yiwen Xian Yu Yang Chong Zhang Decheng Wu Source Type: research
Photopolymerizable and Antibacterial Hydrogels Loaded with Metabolites from < em > Lacticaseibacillus rhamnosus GG < /em > for Infected Wound Healing
This study provides a facile strategy and insights into the functional design of hydrogels from the perspective of wound microenvironment regulation.PMID:38527924 | DOI:10.1021/acs.biomac.4c00124 (Source: Biomacromolecules)
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Yanting Han Zhe Yin Yilin Wang Yuanzhang Jiang Jianming Chen Zhonghua Miao Fang He Ruyue Cheng Lin Tan Ka Li Source Type: research
Advances in Polysaccharides for Cartilage Tissue Engineering Repair: A Review
Biomacromolecules. 2024 Mar 24. doi: 10.1021/acs.biomac.3c01424. Online ahead of print.ABSTRACTCartilage repair has been a significant challenge in orthopedics that has not yet been fully resolved. Due to the absence of blood vessels and the almost cell-free nature of mature cartilage tissue, the limited ability to repair cartilage has resulted in significant socioeconomic pressures. Polysaccharide materials have recently been widely used for cartilage tissue repair due to their excellent cell loading, biocompatibility, and chemical modifiability. They also provide a suitable microenvironment for cartilage repair and regen...
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Heng An Meng Zhang Zhen Gu Xiangyu Jiao Yinglei Ma Zhe Huang Yongqiang Wen Yaozhong Dong Peixun Zhang Source Type: research
Correction to "Fibrin-Dextran Hydrogels with Tunable Porosity and Mechanical Properties"
Biomacromolecules. 2024 Mar 25. doi: 10.1021/acs.biomac.4c00276. Online ahead of print.NO ABSTRACTPMID:38525496 | DOI:10.1021/acs.biomac.4c00276 (Source: Biomacromolecules)
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Shannon Anna Jung Hanna Malyaran Dan Eugen Demco Anna Manukanc Leonie Sophie H äser Vytautas Ku čikas Marc van Zandvoort Sabine Neuss Andrij Pich Source Type: research
Versatile Triblock Peptide Self-Assembly System to Mimic Collagen Structure and Function
Biomacromolecules. 2024 Mar 25. doi: 10.1021/acs.biomac.4c00033. Online ahead of print.ABSTRACTThe construction of collagen mimetic peptides has been a hot topic in tissue engineering due to their attractive advantages, such as virus-free nature and low immunogenicity. However, all of the reported self-assembled peptides rely on the inclusion of risky elements of potential safety concerns or lack the capability of incorporating critical functional motifs. A versatile self-assembly design of pure synthetic peptides that can mimic the collagen structure and function remains an insurmountably challenging target. We have herei...
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Linyan Yao Biyang Ling Wenjie Huang Shuangni Shi Jianxi Xiao Source Type: research
Naturally Derived Injectable Dual-Cross-Linked Adhesive Hydrogel for Acute Hemorrhage Control and Wound Healing
Biomacromolecules. 2024 Mar 25. doi: 10.1021/acs.biomac.4c00105. Online ahead of print.ABSTRACTDeveloping biocompatible injectable hydrogels with high mechanical strength and rapid strong tissue adhesion for hemostatic sealing of uncontrolled bleeding remains a prevailing challenge. Herein, we engineer an injectable and photo-cross-linkable hydrogel based on naturally derived gelatin methacrylate (GelMA) and N-hydroxysuccinimide-modified poly(γ-glutamic acid) (γPGA-NHS). The chemically dual-cross-linked hydrogel rapidly forms after UV light irradiation and covalently bonds to the underlying tissue to provide robust adhes...
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Ziran Zhu Huijun Ye Kaiwen Zhang Gang He Zheng Pan Yiwen Xian Yu Yang Chong Zhang Decheng Wu Source Type: research
Producing Cellulose Microfibrils at a High Solid Content with and without Mechanical or Enzymatic Pretreatment
This study conducted a detailed evaluation of the feasibility of producing cellulose microfibrils (CMF) from a kraft-bleached hardwood pulp at high solid contents with and without pretreatments. CMFs produced by planetary ball milling at solid contents 17 and 28% were compared with those from 1 to 5% under the same milling conditions. Fiber pretreatments using a commercial endoglucanase and mechanical refining using a laboratory PFI mill were also applied before ball milling at a solid content of 28%. Two mechanisms of fiber fibrillation were identified from the results obtained: (i) ball and fiber/fibril interactions─th...
Source: Biomacromolecules - March 21, 2024 Category: Biochemistry Authors: Xiaoxue Zhang Daniel J Yelle Peter Kitin Guolin Tong J Y Zhu Source Type: research
Producing Cellulose Microfibrils at a High Solid Content with and without Mechanical or Enzymatic Pretreatment
This study conducted a detailed evaluation of the feasibility of producing cellulose microfibrils (CMF) from a kraft-bleached hardwood pulp at high solid contents with and without pretreatments. CMFs produced by planetary ball milling at solid contents 17 and 28% were compared with those from 1 to 5% under the same milling conditions. Fiber pretreatments using a commercial endoglucanase and mechanical refining using a laboratory PFI mill were also applied before ball milling at a solid content of 28%. Two mechanisms of fiber fibrillation were identified from the results obtained: (i) ball and fiber/fibril interactions─th...
Source: Biomacromolecules - March 21, 2024 Category: Biochemistry Authors: Xiaoxue Zhang Daniel J Yelle Peter Kitin Guolin Tong J Y Zhu Source Type: research
