Water and Oxygen Barrier Properties of All-Cellulose Nanocomposites
Biomacromolecules. 2024 Feb 23. doi: 10.1021/acs.biomac.3c01337. Online ahead of print.ABSTRACTHydroxypropyl cellulose (HPC) is potentially interesting as a biobased, rigid food packaging material, but its stiffness and strength are somewhat low, and its water and oxygen transport rates are too high. To improve these characteristics, we investigated nanocomposites of HPC and cellulose nanocrystals (CNCs). These high-aspect-ratio nanoparticles display high stiffness and strength, and their high crystallinity renders them virtually impermeable. Exchanging the counterions of sulfate-ester decorated CNCs with cetyltrimethylamm...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Chris Rader Luca Grillo Christoph Weder Source Type: research
Insight into the Feasibility of Fatty Acyl Chlorides with 10-18 Carbons for the Ball-Milling Synthesis of Thermoplastic Cellulose Esters
This study provides some theoretical basis for the mechanochemical synthesis of thermoplastic FACE with designated properties.PMID:38394470 | DOI:10.1021/acs.biomac.3c01354 (Source: Biomacromolecules)
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: De-Fa Hou Pei-Yao Li Kai Zhang Meng-Lei Li Zi-Wei Feng Cong Yan Can Liu Ming-Bo Yang Source Type: research
Aptamer-Targeted Dendrimersomes Assembled from Azido-Modified Janus Dendrimers "Clicked" to DNA
Biomacromolecules. 2024 Feb 23. doi: 10.1021/acs.biomac.3c01108. Online ahead of print.ABSTRACTAmphiphilic Janus dendrimers (JDs), synthetic alternatives to lipids, have the potential to expand the scope of nanocarrier delivery systems. JDs self-assemble into vesicles called dendrimersomes, encapsulate both hydrophobic cargo and nucleic acids, and demonstrate enhanced stability in comparison to lipid nanoparticles (LNPs). Here, we report the ability to enhance the cellular uptake of Janus dendrimersomes using DNA aptamers. Azido-modified JDs were synthesized and conjugated to alkyne-modified DNAs using copper-catalyzed azi...
Source: Biomacromolecules - February 23, 2024 Category: Biochemistry Authors: Paige Bristow Kyle Schantz Zoe Moosbrugger Kailey Martin Haley Liebenberg Stefan Steimle Qi Xiao Virgil Percec Samantha E Wilner Source Type: research
High-Quality Cellulosic Fibers Engineered from Cotton-Elastane Textile Waste
Biomacromolecules. 2024 Feb 22. doi: 10.1021/acs.biomac.3c01366. Online ahead of print.ABSTRACTEven small amounts of elastane in cotton-elastane blended textiles can prevent fiber-to-fiber recycling strategies in textile recycling. Herein, the selective separation of elastane from cotton blends was addressed by the aminolytic degradation of the synthetic component. Polar aprotic solvents were tested as elastane solvents, but side reactions impeded aminolysis with some of them. Aminolysis of elastane succeeded under mild conditions using dimethyl sulfoxide in combination with diethylenetriamine and 1,5-diazabicyclo[4.3.0]no...
Source: Biomacromolecules - February 22, 2024 Category: Biochemistry Authors: Lorena Villar Inge Schlapp-Hackl Pablo B S ánchez Michael Hummel Source Type: research
One-Pot Fabrication of Supramolecular Synthetic Protein Hydrogel with Tissue-like Integrated Dynamic Features
Biomacromolecules. 2024 Feb 22. doi: 10.1021/acs.biomac.3c01451. Online ahead of print.ABSTRACTProtein-incorporated soft networks have received remarkable attention during the past several years. They possess desirable properties similar to native tissues and organs and exhibit unique advantages in applications. However, fabrication of protein-based hydrogels usually suffers from complex protein mutation and modification or chemical synthesis, which limited the scale and yield of production. Meanwhile, the lack of rationally designed noncovalent interactions in networks may result in a deficiency of the dynamic features of...
Source: Biomacromolecules - February 22, 2024 Category: Biochemistry Authors: Chendi Gao Ensong Zhang Xinyu Bian Qiaoran Li Chunming Wang Guang Yang Ming Jiang Guosong Chen Source Type: research
Antifreeze Polysaccharides from Wheat Bran: The Structural Characterization and Antifreeze Mechanism
In this study, various antifreeze polysaccharides were isolated from wheat bran, and the antifreeze activity was comparatively studied in relation to the molecular structure. The antifreeze mechanism was further revealed based on the interactions of polysaccharides and water molecules through dynamic simulation analysis. The antifreeze polysaccharides showed distinct ice recrystallization inhibition activity, and structural analysis suggested that the polysaccharides were arabinoxylan, featuring a xylan backbone with a majority of Araf and minor fractions of Manp, Galp, and Glcp involved in the side chain. The antifreeze a...
Source: Biomacromolecules - February 22, 2024 Category: Biochemistry Authors: Tao Yang Yining Zhang Li Guo Dandan Li Anqi Liu Muhammad Bilal Chong Xie Runqiang Yang Zhenxin Gu Dong Jiang Pei Wang Source Type: research
High-Quality Cellulosic Fibers Engineered from Cotton-Elastane Textile Waste
Biomacromolecules. 2024 Feb 22. doi: 10.1021/acs.biomac.3c01366. Online ahead of print.ABSTRACTEven small amounts of elastane in cotton-elastane blended textiles can prevent fiber-to-fiber recycling strategies in textile recycling. Herein, the selective separation of elastane from cotton blends was addressed by the aminolytic degradation of the synthetic component. Polar aprotic solvents were tested as elastane solvents, but side reactions impeded aminolysis with some of them. Aminolysis of elastane succeeded under mild conditions using dimethyl sulfoxide in combination with diethylenetriamine and 1,5-diazabicyclo[4.3.0]no...
Source: Biomacromolecules - February 22, 2024 Category: Biochemistry Authors: Lorena Villar Inge Schlapp-Hackl Pablo B S ánchez Michael Hummel Source Type: research
One-Pot Fabrication of Supramolecular Synthetic Protein Hydrogel with Tissue-like Integrated Dynamic Features
Biomacromolecules. 2024 Feb 22. doi: 10.1021/acs.biomac.3c01451. Online ahead of print.ABSTRACTProtein-incorporated soft networks have received remarkable attention during the past several years. They possess desirable properties similar to native tissues and organs and exhibit unique advantages in applications. However, fabrication of protein-based hydrogels usually suffers from complex protein mutation and modification or chemical synthesis, which limited the scale and yield of production. Meanwhile, the lack of rationally designed noncovalent interactions in networks may result in a deficiency of the dynamic features of...
Source: Biomacromolecules - February 22, 2024 Category: Biochemistry Authors: Chendi Gao Ensong Zhang Xinyu Bian Qiaoran Li Chunming Wang Guang Yang Ming Jiang Guosong Chen Source Type: research
Antifreeze Polysaccharides from Wheat Bran: The Structural Characterization and Antifreeze Mechanism
In this study, various antifreeze polysaccharides were isolated from wheat bran, and the antifreeze activity was comparatively studied in relation to the molecular structure. The antifreeze mechanism was further revealed based on the interactions of polysaccharides and water molecules through dynamic simulation analysis. The antifreeze polysaccharides showed distinct ice recrystallization inhibition activity, and structural analysis suggested that the polysaccharides were arabinoxylan, featuring a xylan backbone with a majority of Araf and minor fractions of Manp, Galp, and Glcp involved in the side chain. The antifreeze a...
Source: Biomacromolecules - February 22, 2024 Category: Biochemistry Authors: Tao Yang Yining Zhang Li Guo Dandan Li Anqi Liu Muhammad Bilal Chong Xie Runqiang Yang Zhenxin Gu Dong Jiang Pei Wang Source Type: research
Optimized Design of Hyaluronic Acid-Lipid Conjugate Biomaterial for Augmenting CD44 Recognition of Surface-Engineered NK Cells
In this study, we optimized amphiphilic balances of NK cell coating materials composed of CD44-targeting hyaluronic acid (HA)-poly(ethylene glycol) (PEG)-lipid to improve TNBC recognition and the anticancer effect. Changes in the modular design of our material by differentiating hydrophilic PEG length and incorporating lipid amount into HA backbones precisely regulated the amphiphilic nature of HA-PEG-lipid conjugates. The optimized biomaterial demonstrated improved anchoring into NK cell membranes and facilitating the surface presentation level of HA onto NK cell surfaces. This led to enhanced cancer targeting via increas...
Source: Biomacromolecules - February 21, 2024 Category: Biochemistry Authors: Hee Won Park Wonjeong Lee Sungjun Kim Ashok Kumar Jangid Jaewon Park Chae Eun Lee Kyobum Kim Source Type: research
Decreased Lung Metastasis in Triple Negative Breast Cancer Following Locally Delivered Supratherapeutic Paclitaxel-Loaded Polyglycerol Carbonate Nanoparticle Therapy
Biomacromolecules. 2024 Feb 21. doi: 10.1021/acs.biomac.3c01258. Online ahead of print.ABSTRACTBreast cancer is among the most prevalent malignancies, accounting for 685,000 deaths worldwide in 2020, largely due to its high metastatic potential. Depending on the stage and tumor characteristics, treatment involves surgery, chemotherapy, targeted biologics, and/or radiation therapy. However, current treatments are insufficient for treating or preventing metastatic disease. Herein, we describe supratherapeutic paclitaxel-loaded nanoparticles (81 wt % paclitaxel) to treat the primary tumor and reduce the risk of subsequent met...
Source: Biomacromolecules - February 21, 2024 Category: Biochemistry Authors: Robert C Sabatelle Ngoc-Quynh Chu William Blessing Hussein Kharroubi Eric Bressler Lillian Tsai Angela Shih Mark W Grinstaff Yolonda Colson Source Type: research
Injectable Alginate Complex Hydrogel Loaded with Dual-Drug Nanovectors Offers Effective Photochemotherapy against Triple-Negative Breast Cancer
In this study, an injectable alginate complex hydrogel loaded with indocyanine green (ICG)-entrapped perfluorocarbon nanoemulsions (IPNEs) and camptothecin (CPT)-doped chitosan nanoparticles (CCNPs), named IPECCNAHG, was developed for photochemotherapy against TNBC. IPNEs with perfluorocarbon can induce hyperthermia and generate more singlet oxygen than an equal dose of free ICG upon near-infrared (NIR) irradiation to achieve photothermal and photodynamic therapy. CCNPs with positive charge may facilitate cellular internalization and provide sustained release of CPT to carry out chemotherapy. Both nanovectors can stabilize...
Source: Biomacromolecules - February 21, 2024 Category: Biochemistry Authors: Yu-Hsiang Lee Chih-Ting Lin Source Type: research
One-Component Nanocomposites Made from Diblock Copolymer Grafted Cellulose Nanocrystals
Biomacromolecules. 2024 Feb 21. doi: 10.1021/acs.biomac.3c01196. Online ahead of print.ABSTRACTCellulose nanocrystals (CNCs) are bio-based, rod-like, high-aspect-ratio nanoparticles with high stiffness and strength and are widely used as a reinforcing nanofiller in polymer nanocomposites. However, due to hydrogen-bond formation between the large number of hydroxyl groups on their surface, CNCs are prone to aggregate, especially in nonpolar polymer matrices. One possibility to overcome this problem is to graft polymers from the CNCs' surfaces and to process the resulting "hairy nanoparticles" (HNPs) into one-component nanoc...
Source: Biomacromolecules - February 21, 2024 Category: Biochemistry Authors: Chris Rader Patrick W Fritz Timur Ashirov Ali Coskun Christoph Weder Source Type: research
High-Strength, High-Swelling-Resistant, High-Sensitivity Hydrogel Sensor Prepared with Wood That Retains Lignin
In this study, we displayed the preparation of highly dimensional stable wood/polyacrylamide hydrogels (wood/PAM-Al3+). The alkali-treated wood retains lignin as the skeleton of the hydrogel. Second, Al ions were added to the metal coordination with lignin. Finally, by employing free radical polymerization, we construct a conductive electronic network using polyaniline within the wood/PAM-Al3+ matrix to create the flexible sensor. This approach leverages lignin's integrated structure within the middle lamella to provide enhanced swelling resistance and stronger binding strength in the transverse direction. Furthermore, coo...
Source: Biomacromolecules - February 21, 2024 Category: Biochemistry Authors: Xiangzhen Meng Jing Zhou Xin Jin Changlei Xia Shanyu Ma Shu Hong John Tosin Aladejana Anran Dong Yujia Luo Jianzhang Li Xianxu Zhan Rui Yang Source Type: research
Optimized Design of Hyaluronic Acid-Lipid Conjugate Biomaterial for Augmenting CD44 Recognition of Surface-Engineered NK Cells
In this study, we optimized amphiphilic balances of NK cell coating materials composed of CD44-targeting hyaluronic acid (HA)-poly(ethylene glycol) (PEG)-lipid to improve TNBC recognition and the anticancer effect. Changes in the modular design of our material by differentiating hydrophilic PEG length and incorporating lipid amount into HA backbones precisely regulated the amphiphilic nature of HA-PEG-lipid conjugates. The optimized biomaterial demonstrated improved anchoring into NK cell membranes and facilitating the surface presentation level of HA onto NK cell surfaces. This led to enhanced cancer targeting via increas...
Source: Biomacromolecules - February 21, 2024 Category: Biochemistry Authors: Hee Won Park Wonjeong Lee Sungjun Kim Ashok Kumar Jangid Jaewon Park Chae Eun Lee Kyobum Kim Source Type: research
