Synthesis of Biobased Poly(butylene Furandicarboxylate) Containing Polysulfone with Excellent Thermal Resistance Properties
Biomacromolecules. 2024 Feb 9. doi: 10.1021/acs.biomac.3c01272. Online ahead of print.ABSTRACTA synthetic biopolymer derived from furandicarboxylic acid monomer and hydroxyethyl-terminated poly(ether sulfone) is presented. The synthesis involves 4,4'-dichlorodiphenyl sulfone and 4,4-dihydroxydiphenyl sulfone, resulting in poly(butylene furandicarboxylate)-poly(ether sulfone) copolyesters (PBFES) through melt polycondensation with titanium-catalyzed polymerization. This facile method yields segmented polyesters incorporating polysulfone, creating a versatile group of high-temperature thermoplastics with adjustable thermomec...
Source: Biomacromolecules - February 9, 2024 Category: Biochemistry Authors: Xinhong Cai Xuefeng Zhao Sakil Mahmud Xiaoqin Zhang Xiaoxing Wang Jinggang Wang Jin Zhu Source Type: research

From Soy Waste to Bioplastics: Industrial Proof of Concept
Biomacromolecules. 2024 Feb 7. doi: 10.1021/acs.biomac.3c01416. Online ahead of print.ABSTRACTThe global plastic waste problem is pushing for the development of sustainable alternatives, encouraged by stringent regulations combined with increased environmental consciousness. In response, this study presents an industrial-scale proof of concept to produce self-standing, transparent, and flexible bioplastic films, offering a possible solution to plastic pollution and resource valorization. We achieve this by combining amyloid fibrils self-assembled from food waste with methylcellulose and glycerol. Specifically, soy whey and...
Source: Biomacromolecules - February 8, 2024 Category: Biochemistry Authors: Massimo Bagnani Mohammad Peydayesh Thomas Knapp Edouard Appenzeller Daniel Sutter Stefan Kr änzlin Yi Gong Alexandra Wehrle Stella Greuter Matthias Bucher Markus Schmid Raffaele Mezzenga Source Type: research

Chirality-Regulated Clusteroluminescence in Polypeptides
Biomacromolecules. 2024 Feb 8. doi: 10.1021/acs.biomac.3c01328. Online ahead of print.ABSTRACTThe low emission efficiency of clusteroluminogens restricts their practical applications in the fields of sensors and biological imaging. In this work, the clusteroluminescence of ordered/disordered polypeptides was observed, and the photoluminescence (PL) intensity of polypeptides can be modulated by the chirality of amino acid residues. Polyglutamates with different chiral compositions were synthesized, and the racemic polypeptides exhibited a significantly higher PL intensity than the enantiopure ones. This emission originates ...
Source: Biomacromolecules - February 8, 2024 Category: Biochemistry Authors: Wangtao Zhao Mei Gao Liufen Kong Shunfeng Yu Chuanzhuang Zhao Chongyi Chen Source Type: research

Antioxidant Polymers with Phenolic Pendants for the Mitigation of Cellular Oxidative Stress
Biomacromolecules. 2024 Feb 8. doi: 10.1021/acs.biomac.3c01193. Online ahead of print.ABSTRACTOverproduction of reactive oxygen species (ROS) in cells is a major health concern as it may lead to various diseases through oxidative damage of biomolecules. Commonly used traditional small molecular antioxidants (polyphenols, carotenoids, vitamins, etc.) have inadequate efficacy in lowering excessive levels of ROS due to their poor aqueous solubility and bioavailability. In response to the widespread occurrence of antioxidant polyphenols in various biorenewable resources, we aimed to develop water-soluble antioxidant polymers w...
Source: Biomacromolecules - February 8, 2024 Category: Biochemistry Authors: Anushree Mondal Arpita Pal Subhasish Sarkar Rupak Datta Priyadarsi De Source Type: research

Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructs
This study shows that hybrid cartilage constructs can be engineered with tunable mechanical properties by grafting silkMA hydrogels covalently to pMHMGCL:PCL blend microfibers at the interface.PMID:38323427 | DOI:10.1021/acs.biomac.3c01147 (Source: Biomacromolecules)
Source: Biomacromolecules - February 7, 2024 Category: Biochemistry Authors: Martina Viola Madison J Ainsworth Marko Mihajlovic Gerardo Cedillo-Servin Mies J van Steenbergen Mattie van Rijen Myl ène de Ruijter Miguel Castilho Jos Malda Tina Vermonden Source Type: research

Effective Treatment of < em > Helicobacter pylori < /em > Infection Using Supramolecular Antimicrobial Peptide Hydrogels
Biomacromolecules. 2024 Feb 7. doi: 10.1021/acs.biomac.3c01141. Online ahead of print.ABSTRACTHelicobacter pylori can cause various gastric conditions including stomach cancer in an acidic environment. Although early H. pylori infections can be treated by antibiotics, prolonged antibiotic administrations may lead to the development of antimicrobial resistance, compromising the effectiveness of the treatments. Antimicrobial peptides (AMPs) have been reported to possess unique advantages against antimicrobial-resistant bacteria due to their rapid physical membrane disruptions and anti-inflammation/immunoregulation properties...
Source: Biomacromolecules - February 7, 2024 Category: Biochemistry Authors: Haoning Gong Xiaonan Wang Xuzhi Hu Mingrui Liao Chengqian Yuan Jian Ren Lu Lizeng Gao Xuehai Yan Source Type: research

Study on the Rectification of Ionic Diode Based on Cross-Linked Nanocellulose Bipolar Membranes
Biomacromolecules. 2024 Feb 7. doi: 10.1021/acs.biomac.3c01353. Online ahead of print.ABSTRACTNanocellulose-based membranes have attracted intense attention in bioelectronic devices due to their low cost, flexibility, biocompatibility, degradability, and sustainability. Herein, we demonstrate a flexible ionic diode using a cross-linked bipolar membrane fabricated from positively and negatively charged cellulose nanofibrils (CNFs). The rectified current originates from the asymmetric charge distribution, which can selectively determine the direction of ion transport inside the bipolar membrane. The mechanism of rectificatio...
Source: Biomacromolecules - February 7, 2024 Category: Biochemistry Authors: Hongli Yang Jesper Edberg Mehmet Girayhan Say Johan Erlandsson Viktor Gueskine Lars W ågberg Magnus Berggren Isak Engquist Source Type: research

DLP Fabrication of Multiple Hierarchical Biomimetic GelMA/SilMA/HAp Scaffolds for Enhancing Bone Regeneration
In this study, a hierarchical biomimetic microporous hydrogel composite scaffold was constructed by mimicking the hierarchical structure of bone. Initially, gelatin methacrylamide (GelMA) and methacrylic anhydride silk fibroin (SilMA) were synthesized, and GelMA/SilMA inks with suitable rheological and mechanical properties were prepared. Biomimetic micropores were then generated by using an aqueous two-phase emulsification method. Subsequently, biomimetic microporous GelMA/SilMA was mixed with hydroxyapatite (HAp) to prepare biomimetic microporous GelMA/SilMA/HAp ink. Hierarchical biomimetic microporous GelMA/SilMA/HAp (M...
Source: Biomacromolecules - February 7, 2024 Category: Biochemistry Authors: Ping Song Xingyu Gui Lina Wu Xinyu Su Wenzheng Zhou Zeyu Luo Boqing Zhang Pin Feng Wei Wei Chen Fan Yunhong Wu Weinan Zeng Changchun Zhou Yujiang Fan Zongke Zhou Source Type: research

Enhancing Mucoadhesive Properties of Gelatin through Chemical Modification with Unsaturated Anhydrides
In this study, gelatin was modified by reacting with crotonic, itaconic, and methacrylic anhydrides in varying molar ratios to yield crotonoylated-, itaconoylated-, and methacryloylated gelatins (abbreviated as Gel-CA, Gel-IA, and Gel-MA, respectively). The successful synthesis was confirmed using 1H NMR, FTIR spectroscopies, and colorimetric TNBSA assay. The effect of chemical modification on the isoelectric point was studied through viscosity and electrophoretic mobility measurements. The evolution of the storage (G') and loss (G'') moduli was employed to determine thermoreversible gelation points of modified and unmodif...
Source: Biomacromolecules - February 6, 2024 Category: Biochemistry Authors: Elvira O Shatabayeva Daulet B Kaldybekov Leila Ulmanova Balnur A Zhaisanbayeva Ellina A Mun Zarina A Kenessova Sarkyt E Kudaibergenov Vitaliy V Khutoryanskiy Source Type: research

Proline-Tyrosine Ring Interactions in Black Widow Dragline Silk Revealed by Solid-State Nuclear Magnetic Resonance and Molecular Dynamics Simulations
Biomacromolecules. 2024 Feb 5. doi: 10.1021/acs.biomac.3c01351. Online ahead of print.ABSTRACTSelective one-dimensional 13C-13C spin-diffusion solid-state nuclear magnetic resonance (SSNMR) provides evidence for CH/π ring packing interactions between Pro and Tyr residues in 13C-enriched Latrodectus hesperus dragline silk. The secondary structure of Pro-containing motifs in dragline spider silks consistently points to an elastin-like type II β-turn conformation based on 13C chemical shift analysis. 13C-13C spin diffusion measurements as a function of mixing times allow for the measurement of spatial proximity between the ...
Source: Biomacromolecules - February 5, 2024 Category: Biochemistry Authors: Kevin Chalek Ashana Soni Christian D Lorenz Gregory P Holland Source Type: research

Periodontium-Mimicking, Multifunctional Biomass-Based Hydrogel Promotes Full-Course Socket Healing
In conclusion, the periodontium-mimicking multifunctional hydrogel exhibits significant potential as a clinical tooth extraction wound dressing.PMID:38305191 | DOI:10.1021/acs.biomac.3c01221 (Source: Biomacromolecules)
Source: Biomacromolecules - February 2, 2024 Category: Biochemistry Authors: Yuxuan Guo Zijian Shao Wenjie Wang Huaze Liu Weifeng Zhao Liao Wang Chongyun Bao Source Type: research

Injectable Extracellular Matrix-Inspired Hemostatic Hydrogel Composed of Hyaluronan and Gelatin with Shear-Thinning and Self-Healing
Biomacromolecules. 2024 Feb 2. doi: 10.1021/acs.biomac.3c01251. Online ahead of print.ABSTRACTInjectable ECM-inspired hydrogels composed of hyaluronic acid and gelatin are biocompatible and potentially useful for various medical applications. We developed injectable hydrogels composed of monoaldehyde-modified hyaluronic acid (HA-mCHO) and carbohydrazide-modified gelatin (GL-CDH), "HA/GL gel", whose ratios of HA-mCHO to GL-CDH were different. The hydrogels exhibited gelation times shorter than 3 s. In addition, the hydrogels showed strong shear-thinning and self-healing properties, mainly because of the dynamic covalent bon...
Source: Biomacromolecules - February 2, 2024 Category: Biochemistry Authors: Momoko Kamedani Masashi Okawa Athira Sreedevi Madhavikutty Ching-Cheng Tsai Arvind K Singh Chandel Takeshi Fujiyabu Natsuko F Inagaki Taichi Ito Source Type: research

Silk Protein-Based Nanoporous Microsphere for Controllable Drug Delivery through Self-Assembly in Ionic Liquid System
In this study, nanoporous microsphere of silk protein and blending with poly(d,l-lactic acid) as model drug delivery was fabricated, respectively, through an IL-induced self-assembly method. Their morphology, structure, and thermal properties were comparably investigated through scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, differential scanning calorimetry, X-ray diffraction, and thermogravimetric analyses, and the interaction mechanisms were also discussed to elucidate the effect of structure on drug delivery kinetics. The pure p...
Source: Biomacromolecules - February 2, 2024 Category: Biochemistry Authors: Qianqian Deng Ping Lin Hanling Gu Xincheng Zhuang Fang Wang Source Type: research

Introducing the New < em > Biomacromolecules < /em > Early Career Board
Biomacromolecules. 2024 Feb 12;25(2):533-540. doi: 10.1021/acs.biomac.4c00079. Epub 2024 Feb 1.NO ABSTRACTPMID:38300876 | DOI:10.1021/acs.biomac.4c00079 (Source: Biomacromolecules)
Source: Biomacromolecules - February 1, 2024 Category: Biochemistry Authors: Maria C Arno Jessica Kramer S ébastien Lecommandoux Source Type: research

Injectable Peptide Hydrogels Loaded with Murine Embryonic Stem Cells Relieve Ischemia < em > In Vivo < /em > after Myocardial Infarction
Biomacromolecules. 2024 Feb 12;25(2):1319-1329. doi: 10.1021/acs.biomac.3c01345. Epub 2024 Jan 30.ABSTRACTMyocardial infarction (MI) is a major cause of morbidity and mortality worldwide, especially in aging and metabolically unhealthy populations. A major target of regenerative tissue engineering is the restoration of viable cardiomyocytes to preserve cardiac function and circumvent the progression to heart failure post-MI. Amelioration of ischemia is a crucial component of such restorative strategies. Angiogenic β-sheet peptides can self-assemble into thixotropic nanofibrous hydrogels. These syringe aspiratable cytocomp...
Source: Biomacromolecules - January 31, 2024 Category: Biochemistry Authors: Abhishek Roy Lei Hao Jamie Francisco Jin Guan Satvik Mareedu Peiyong Zhai Joseph Dodd-O Corey Heffernan Dominic Del Re Eun Jung A Lee Vivek A Kumar Source Type: research