Sweet Janus Particles: Multifunctional Inhibitors of Carbohydrate-Based Bacterial Adhesion
Biomacromolecules. 2024 Mar 7. doi: 10.1021/acs.biomac.3c01333. Online ahead of print.ABSTRACTEscherichia coli and other bacteria use adhesion receptors, such as FimH, to attach to carbohydrates on the cell surface as the first step of colonization and infection. Efficient inhibitors that block these interactions for infection treatment are multivalent carbohydrate-functionalized scaffolds. However, these multivalent systems often lead to the formation of large clusters of bacteria, which may pose problems for clearing bacteria from the infected site. Here, we present Man-containing Janus particles (JPs) decorated on one s...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Serap Üclü Claudia Marschelke Felictas Drees Markus Giesler Dimitri Wilms Thorben K öhler Stephan Schmidt Alla Synytska Laura Hartmann Source Type: research
Dual-Modified Hyaluronic Acid for Tunable Double Cross-Linked Hydrogel Adhesives
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.4c00194. Online ahead of print.ABSTRACTConventional techniques for the closure of wounds, such as sutures and staples, have significant drawbacks that can negatively impact wound healing. Tissue adhesives have emerged as promising alternatives, but poor adhesion, low mechanical properties, and toxicity have hindered their widespread clinical adoption. In this work, a dual modified, aldehyde and methacrylate hyaluronic acid (HA) biopolymer (HA-MA-CHO) has been synthesized through a simplified route for use as a double cross-linked network (DCN) hydrogel (HA-MA-CHO-DCN) ...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Cameron Milne Rijian Song Melissa Johnson Chunyu Zhao Francesca Santoro Ferrer Sigen A Jing Lyu Wenxin Wang Source Type: research
Irradiation Behavior of Analgesic and Nonsteroidal Anti-Inflammatory Drug-Loaded UHMWPE for Joint Replacement
In this study, we used ultrahigh molecular weight polyethylene (UHMWPE), commonly employed as a bearing material for joint implants, to deliver a wide set of analgesics and the nonsteroidal anti-inflammatory drug tolfenamic acid. We blended the drugs with UHMWPE and processed the blend by compression molding and sterilization by low-dose gamma irradiation. We studied the chemical stability of the eluted drugs, drug elution, tensile properties, and wear resistance of the polymer blends before and after sterilization. The incorporation of bupivacaine hydrochloride and tolfenamic acid in UHMWPE resulted in either single- or d...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Sashank Lekkala Nicoletta Inverardi Scott C Grindy Shannon Hugard Orhun K Muratoglu Ebru Oral Source Type: research
Benchmarking the Humidity-Dependent Mechanical Response of (Nano)fibrillated Cellulose and Dissolved Polysaccharides as Sustainable Sand Amendments
In this study, we evaluate the potential benefits that are brought to inert sand by the incorporation of a range of, mainly, cellulosic networks in their polymeric or structured (fiber) forms, analogously to those found in healthy soils. We explore the impact of a wide range of nonfood polysaccharide-based amendments, including pulp fibers, nanocellulose, cellulose derivatives, and other readily available polysaccharide structures derived from arthropods (chitosan) or fruit peels (pectin) residues. A practical methodology is presented to form sand-polymer composites, which are evaluated for their soil mechanics as a functi...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: M-Haidar A Dali Roozbeh Abidnejad Mohamed Hamid Salim Mamata Bhattarai Monireh Imani Orlando J Rojas Luiz G Greca Blaise L Tardy Source Type: research
Postpolymerization Modification of Poly(2-vinyl-4,4-dimethyl azlactone) as a Versatile Strategy for Drug Conjugation and Stimuli-Responsive Release
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.4c00181. Online ahead of print.ABSTRACTPostpolymerization modification of highly defined "scaffold" polymers is a promising approach for overcoming the existing limitations of controlled radical polymerization such as batch-to-batch inconsistencies, accessibility to different monomers, and compatibility with harsh synthesis conditions. Using multiple physicochemical characterization techniques, we demonstrate that poly(2-vinyl-4,4-dimethyl azlactone) (PVDMA) scaffolds can be efficiently modified with a coumarin derivative, doxorubicin, and camptothecin small molecule d...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Sk Arif Mohammad Veeresh B Toragall Alex Fortenberry Oluwaseyi Shofolawe-Bakare Suresh Sulochana Katie Heath Iyanuoluwani Owolabi Garrett Tassin Alex S Flynt Adam E Smith Thomas Werfel Source Type: research
Multifunctional Hydrogel Enhances Inflammatory Control, Antimicrobial Activity, and Oxygenation to Promote Healing in Infectious Wounds
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.3c01386. Online ahead of print.ABSTRACTChronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) and inflammation is a major contributing factor to the difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel is composed of ε-polylysine grafted (EPL) with caffeic acid (CA) and hyaluronic acid (HA) grafted with phenylboronic acid (PBA). Before the gelation process, a mixture CaO2@Cur-PDA (CCP) consisting of calcium peroxide (CaO2) coate...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Yunfeng Tang Renliang Zhao Min Yi Zilu Ge Dong Wang Guanglin Wang Xiangtian Deng Source Type: research
Sweet Janus Particles: Multifunctional Inhibitors of Carbohydrate-Based Bacterial Adhesion
Biomacromolecules. 2024 Mar 7. doi: 10.1021/acs.biomac.3c01333. Online ahead of print.ABSTRACTEscherichia coli and other bacteria use adhesion receptors, such as FimH, to attach to carbohydrates on the cell surface as the first step of colonization and infection. Efficient inhibitors that block these interactions for infection treatment are multivalent carbohydrate-functionalized scaffolds. However, these multivalent systems often lead to the formation of large clusters of bacteria, which may pose problems for clearing bacteria from the infected site. Here, we present Man-containing Janus particles (JPs) decorated on one s...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Serap Üclü Claudia Marschelke Felictas Drees Markus Giesler Dimitri Wilms Thorben K öhler Stephan Schmidt Alla Synytska Laura Hartmann Source Type: research
Dual-Modified Hyaluronic Acid for Tunable Double Cross-Linked Hydrogel Adhesives
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.4c00194. Online ahead of print.ABSTRACTConventional techniques for the closure of wounds, such as sutures and staples, have significant drawbacks that can negatively impact wound healing. Tissue adhesives have emerged as promising alternatives, but poor adhesion, low mechanical properties, and toxicity have hindered their widespread clinical adoption. In this work, a dual modified, aldehyde and methacrylate hyaluronic acid (HA) biopolymer (HA-MA-CHO) has been synthesized through a simplified route for use as a double cross-linked network (DCN) hydrogel (HA-MA-CHO-DCN) ...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Cameron Milne Rijian Song Melissa Johnson Chunyu Zhao Francesca Santoro Ferrer Sigen A Jing Lyu Wenxin Wang Source Type: research
Irradiation Behavior of Analgesic and Nonsteroidal Anti-Inflammatory Drug-Loaded UHMWPE for Joint Replacement
In this study, we used ultrahigh molecular weight polyethylene (UHMWPE), commonly employed as a bearing material for joint implants, to deliver a wide set of analgesics and the nonsteroidal anti-inflammatory drug tolfenamic acid. We blended the drugs with UHMWPE and processed the blend by compression molding and sterilization by low-dose gamma irradiation. We studied the chemical stability of the eluted drugs, drug elution, tensile properties, and wear resistance of the polymer blends before and after sterilization. The incorporation of bupivacaine hydrochloride and tolfenamic acid in UHMWPE resulted in either single- or d...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Sashank Lekkala Nicoletta Inverardi Scott C Grindy Shannon Hugard Orhun K Muratoglu Ebru Oral Source Type: research
Benchmarking the Humidity-Dependent Mechanical Response of (Nano)fibrillated Cellulose and Dissolved Polysaccharides as Sustainable Sand Amendments
In this study, we evaluate the potential benefits that are brought to inert sand by the incorporation of a range of, mainly, cellulosic networks in their polymeric or structured (fiber) forms, analogously to those found in healthy soils. We explore the impact of a wide range of nonfood polysaccharide-based amendments, including pulp fibers, nanocellulose, cellulose derivatives, and other readily available polysaccharide structures derived from arthropods (chitosan) or fruit peels (pectin) residues. A practical methodology is presented to form sand-polymer composites, which are evaluated for their soil mechanics as a functi...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: M-Haidar A Dali Roozbeh Abidnejad Mohamed Hamid Salim Mamata Bhattarai Monireh Imani Orlando J Rojas Luiz G Greca Blaise L Tardy Source Type: research
Postpolymerization Modification of Poly(2-vinyl-4,4-dimethyl azlactone) as a Versatile Strategy for Drug Conjugation and Stimuli-Responsive Release
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.4c00181. Online ahead of print.ABSTRACTPostpolymerization modification of highly defined "scaffold" polymers is a promising approach for overcoming the existing limitations of controlled radical polymerization such as batch-to-batch inconsistencies, accessibility to different monomers, and compatibility with harsh synthesis conditions. Using multiple physicochemical characterization techniques, we demonstrate that poly(2-vinyl-4,4-dimethyl azlactone) (PVDMA) scaffolds can be efficiently modified with a coumarin derivative, doxorubicin, and camptothecin small molecule d...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Sk Arif Mohammad Veeresh B Toragall Alex Fortenberry Oluwaseyi Shofolawe-Bakare Suresh Sulochana Katie Heath Iyanuoluwani Owolabi Garrett Tassin Alex S Flynt Adam E Smith Thomas Werfel Source Type: research
Multifunctional Hydrogel Enhances Inflammatory Control, Antimicrobial Activity, and Oxygenation to Promote Healing in Infectious Wounds
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.3c01386. Online ahead of print.ABSTRACTChronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) and inflammation is a major contributing factor to the difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel is composed of ε-polylysine grafted (EPL) with caffeic acid (CA) and hyaluronic acid (HA) grafted with phenylboronic acid (PBA). Before the gelation process, a mixture CaO2@Cur-PDA (CCP) consisting of calcium peroxide (CaO2) coate...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Yunfeng Tang Renliang Zhao Min Yi Zilu Ge Dong Wang Guanglin Wang Xiangtian Deng Source Type: research
Thermally Reversible Gel-Sol Transition of Hydrogels via Dissociation and Association of an Artificial Protein Nanocage
Biomacromolecules. 2024 Mar 6. doi: 10.1021/acs.biomac.3c01285. Online ahead of print.ABSTRACTOligomeric protein nanocages often disassemble into their subunits and reassemble by external stimuli. Thus, using these nanocages as cross-linkers for hydrogel network structures is a promising approach to allow hydrogels to undergo stimuli-responsive gel-sol transitions or self-healing. Here, we report hydrogels that show a reversible gel-sol transition resulting from the heat-induced dissociation and reassociation of protein nanocages. The hydrogel contained the 60-mer artificial protein nanocage, TIP60, as a supramolecular cro...
Source: Biomacromolecules - March 6, 2024 Category: Biochemistry Authors: Erika Nasu Norifumi Kawakami Shuhei Takamura Atsushi Hotta Ryoichi Arai Kenji Miyamoto Source Type: research
Tuning Supramolecular Chirality in Iodinated Amphiphilic Peptides Through Tripeptide Linker Editing
Biomacromolecules. 2024 Mar 6. doi: 10.1021/acs.biomac.3c01120. Online ahead of print.ABSTRACTProtease-cleavable supramolecular oligopeptide nanofilaments are promising materials for targeted therapeutics and diagnostics. In these systems, single amino acid substitutions can have profound effects on the supramolecular structure and consequent proteolytic degradation, which are critical parameters for their intended applications. Herein, we describe changes to the self-assembly and proteolytic cleavage of iodine containing sequences for future translation into matrix metalloprotease (MMP-9)-activated supramolecular radio-im...
Source: Biomacromolecules - March 6, 2024 Category: Biochemistry Authors: Douglas S MacPherson Dhwanit Dave Salma Kassem Selma Doganata Brian M Zeglis Rein V Ulijn Source Type: research
Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview
Biomacromolecules. 2024 Mar 6. doi: 10.1021/acs.biomac.3c00975. Online ahead of print.ABSTRACTCellulose, the most abundant polymer on Earth, has been widely utilized in its nanoform due to its excellent properties, finding applications across various scientific fields. As the demand for nanocellulose continues to rise and its ease of use becomes apparent, there has been a significant increase in research publications centered on this biomaterial. Nanocellulose, in its different forms, has shown tremendous promise as a tissue engineered scaffold for regeneration and repair. Particularly, nanocellulose-based composites and s...
Source: Biomacromolecules - March 6, 2024 Category: Biochemistry Authors: Mridula Sreedharan Raji Vijayamma Elena Liyaskina Viktor V Revin Muhammad Wajid Ullah Zhijun Shi Guang Yang Yves Grohens Nandakumar Kalarikkal Khalid Ali Khan Sabu Thomas Source Type: research
