Introducing the New < em > Biomacromolecules < /em > Early Career Board
Biomacromolecules. 2024 Feb 12;25(2):533-540. doi: 10.1021/acs.biomac.4c00079. Epub 2024 Feb 1.NO ABSTRACTPMID:38300876 | DOI:10.1021/acs.biomac.4c00079 (Source: Biomacromolecules)
Source: Biomacromolecules - February 1, 2024 Category: Biochemistry Authors: Maria C Arno Jessica Kramer S ébastien Lecommandoux Source Type: research
Injectable Peptide Hydrogels Loaded with Murine Embryonic Stem Cells Relieve Ischemia < em > In Vivo < /em > after Myocardial Infarction
Biomacromolecules. 2024 Feb 12;25(2):1319-1329. doi: 10.1021/acs.biomac.3c01345. Epub 2024 Jan 30.ABSTRACTMyocardial infarction (MI) is a major cause of morbidity and mortality worldwide, especially in aging and metabolically unhealthy populations. A major target of regenerative tissue engineering is the restoration of viable cardiomyocytes to preserve cardiac function and circumvent the progression to heart failure post-MI. Amelioration of ischemia is a crucial component of such restorative strategies. Angiogenic β-sheet peptides can self-assemble into thixotropic nanofibrous hydrogels. These syringe aspiratable cytocomp...
Source: Biomacromolecules - January 31, 2024 Category: Biochemistry Authors: Abhishek Roy Lei Hao Jamie Francisco Jin Guan Satvik Mareedu Peiyong Zhai Joseph Dodd-O Corey Heffernan Dominic Del Re Eun Jung A Lee Vivek A Kumar Source Type: research
Spider-Silk-like Fiber Mat-Covered Polypropylene Warp-Knitted Hernia Mesh for Inhibition of Fibrosis under Dynamic Environment
In this study, three different commercial polypropylene hernia meshes were examined to explore the connection between the fabric structure and mechanical properties. In vitro dynamic culture was used to investigate the mechanism by which the mechanical properties of the mesh in a dynamic environment affect cell differentiation. Additionally, electrospinning was employed to create polycaprolactone spider-silk-like fiber mats to achieve mechanical energy dissipation in dynamic conditions. These fiber mats were then combined with the preferred hernia mesh. The results demonstrated that the composite mesh could reduce the acti...
Source: Biomacromolecules - January 31, 2024 Category: Biochemistry Authors: Yongjie Jiao Xiaowei Yang Yan Li Fujun Wang Lu Wang Chaojing Li Source Type: research
Multifunctional Casein-Based Wound Dressing Capable of Monitoring and Moderating the Proteolytic Activity of Chronic Wounds
This study aimed to develop a casein-based dressing that, by its disappearance, provides information about the activity of proteases and simultaneously harnesses proteolytic activity. Casein films were fabricated by using an aqueous solution, and heat treatment was successfully deployed as a green and clean approach to confer hydrolytic stability. Our results showed that casein-based films' mechanical characteristics, water absorption, and proteolytic stability could be controlled by the length of the heat treatment, which proved to be a useful tool. An increase in the treatment duration from 30 min to 3 h led to toleratio...
Source: Biomacromolecules - January 31, 2024 Category: Biochemistry Authors: Davood Kolahreez Laleh Ghasemi-Mobarakeh Felice Quartinello Falk W Liebner Georg M Guebitz Doris Ribitsch Source Type: research
Retraction of "Marine Macroalgal Polygalactan-Built Nanoparticle Construct for Osteogenesis"
Biomacromolecules. 2024 Feb 12;25(2):1351. doi: 10.1021/acs.biomac.3c00601. Epub 2024 Jan 31.NO ABSTRACTPMID:38295279 | DOI:10.1021/acs.biomac.3c00601 (Source: Biomacromolecules)
Source: Biomacromolecules - January 31, 2024 Category: Biochemistry Authors: Kajal Chakraborty Tima Antony Shubhajit Dhara Source Type: research
Elucidation of the Specific Ion Effects and Intermediate Structures of Cellulose Fibers Swollen in Inorganic Salt Solutions via In Situ X-ray Diffraction
In this study, we studied the intermediate structures of cellulose fibers during their swelling process in ZnCl2 and LiBr solutions via in situ X-ray diffraction. Two swollen phases with characteristic morphologies were observed for both salt treatments. Only the surfaces of the fibers were swollen in ZnCl2, whereas the ions penetrated the fibers and formed complexes with cellulose while the morphology of the fibers was maintained in LiBr. Our findings clarify the reasons that ZnCl2 has been used as an excellent swelling agent, whereas LiBr has been used as a good solvent for cellulose.PMID:38287873 | PMC:PMC10865373 | DOI...
Source: Biomacromolecules - January 30, 2024 Category: Biochemistry Authors: Kayoko Kobayashi Noriyuki Isobe Ryosuke Kusumi Junji Nemoto Masahisa Wada Source Type: research
How Chromophore Labels Shape the Structure and Dynamics of a Peptide Hydrogel
In this study, we demonstrate the impact of an N-terminal group on the self-assembly and rheology of the peptide hydrogel hFF03 (hydrogelating, fibril forming peptide 03) using molecular dynamics simulations, oscillatory shear rheology, and circular dichroism spectroscopy. We find that the chromophore and even its specific regioisomers have a significant influence on the microscopic structure and dynamics of the self-assembled fibril, and on the macroscopic mechanical properties. This is because the chromophore influences the possible salt bridges, which form and stabilize the fibril formation. Furthermore, we find that th...
Source: Biomacromolecules - January 30, 2024 Category: Biochemistry Authors: Frederick Heinz Jonas Proksch Robert F Schmidt Michael Gradzielski Beate Koksch Bettina G Keller Source Type: research
Injectable, Shear-Thinning, Self-Healing, and Self-Cross-Linkable Benzaldehyde-Conjugated Chitosan Hydrogels as a Tissue Adhesive
Biomacromolecules. 2024 Feb 12;25(2):1084-1095. doi: 10.1021/acs.biomac.3c01117. Epub 2024 Jan 30.ABSTRACTBenzaldehyde-conjugated chitosan (CH-CBA) was synthesized by a coupling reaction between chitosan (CH) and carboxybenzaldehyde (CBA). The pH-sensitive self-cross-linking can be achieved through the Schiff base reaction. The degree of substitution (DS) of CH-CBA was controlled at 1.4-12.7% by optimizing the pH and reagent stoichiometry. The dynamic Schiff base linkages conferred strong shear-thinning and self-healing properties to the hydrogels. The viscosity of the 2 wt/v % CH-CBA hydrogel decreased from 5.3 × 107 mPa...
Source: Biomacromolecules - January 30, 2024 Category: Biochemistry Authors: Ching-Cheng Tsai Arvind K Singh Chandel Kento Mitsuhashi Takeshi Fujiyabu Natsuko F Inagaki Taichi Ito Source Type: research
Tilapia-Derived Granular Hydrogel as a 3D Scaffold Promoting Rapid Wound Healing
This study reveals the potential of tilapia skin-based granular hydrogel assembly in wound healing, overcoming conventional hydrogel limits.PMID:38290478 | DOI:10.1021/acs.biomac.3c01137 (Source: Biomacromolecules)
Source: Biomacromolecules - January 30, 2024 Category: Biochemistry Authors: Pilseon Im Hyunsu Shin Jaeyun Kim Source Type: research
Self-Healing Composite Coating Fabricated with a Cystamine Cross-Linked Cellulose Nanocrystal-Stabilized Pickering Emulsion
Biomacromolecules. 2024 Feb 12;25(2):715-728. doi: 10.1021/acs.biomac.3c00915. Epub 2024 Jan 25.ABSTRACTA gelled Pickering emulsion system was fabricated by first stabilizing linseed oil droplets in water with dialdehyde cellulose nanocrystals (DACNCs) and then cross-linking with cystamine. Cross-linking of the DACNCs was shown to occur by a reaction between the amine groups on cystamine and the aldehyde groups on the CNCs, causing gelation of the nanocellulose suspension. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy were used to characterize the cystamine-cross-linked CNCs (cysCNCs), demons...
Source: Biomacromolecules - January 25, 2024 Category: Biochemistry Authors: Guofan Xu Amaka J Onyianta Jean-Charles Eloi Robert L Harniman Jude Laverock Ian Bond Onajite Abafe Diejomaoh Todor T Koev Yaroslav Z Khimyak Stephen J Eichhorn Source Type: research
Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration
Biomacromolecules. 2024 Feb 12;25(2):729-740. doi: 10.1021/acs.biomac.3c00923. Epub 2024 Jan 23.ABSTRACTIntervertebral disk degeneration is a common disease with an unknown etiology. Currently, tissue engineering is considered to be an important method for intervertebral disk repair. Although transplanted stem cells may disrupt the repair process because of apoptosis caused by the oxidative microenvironment. Herein, bone marrow mesenchymal stem cell (BMSC) and Neochlorogenic acid (Ncg) were encapsulated into a GelMA hydrogel as a carrier to protect transplanted stem cells. Ncg effectively inhibited the oxidative stress pro...
Source: Biomacromolecules - January 24, 2024 Category: Biochemistry Authors: Yuekun Fang Jie Hu Yang Zou Zhichen Wang Yuchen Ye Changchun Zhang Source Type: research
Assessment of the Enzymatic Dephosphorylation Kinetics in the Assemblies of a Phosphopentapeptide that Forms Intranuclear Nanoribbons
Biomacromolecules. 2024 Feb 12;25(2):1310-1318. doi: 10.1021/acs.biomac.3c01288. Epub 2024 Jan 24.ABSTRACTAlthough the formation of peptide assemblies catalyzed by alkaline phosphatase (ALP) has received increasing attention in inhibiting cancer cells, the detailed enzyme kinetics of the dephosphorylation of the corresponding phosphopeptide assemblies have yet to be determined. We recently discovered that assemblies from a phosphopentapeptide can form intracellular nanoribbons that kill induced pluripotent stem cells or osteosarcoma cells, but the kinetics of enzymatic dephosphorylation remain unknown. Thus, we chose to ex...
Source: Biomacromolecules - January 24, 2024 Category: Biochemistry Authors: Yuchen Qiao Grace Wu Zhiyu Liu Hongjian He Weiyi Tan Bing Xu Source Type: research
Effects of Drug Conjugation on the Biological Activity of Single-Chain Nanoparticles
Biomacromolecules. 2024 Feb 12;25(2):675-689. doi: 10.1021/acs.biomac.3c00862. Epub 2024 Jan 24.ABSTRACTThe field of single-chain nanoparticles (SCNPs) continues to mature, and an increasing range of reports have emerged that explore the application of these small nanoparticles. A key application for SCNPs is in the field of drug delivery, and recent work suggests that SCNPs can be readily internalized by cells. However, limited attention has been directed to the delivery of small-molecule drugs using SCNPs. Moreover, studies on the physicochemical effects of drug loading on SCNP performance is so far missing, despite the ...
Source: Biomacromolecules - January 24, 2024 Category: Biochemistry Authors: Yen Vo Mitchell D Nothling Radhika Raveendran Cheng Cao Martina H Stenzel Source Type: research
FAP Targeting of Photosensitizer-Loaded Polymersomes for Increased Light-Activated Cell Killing
Biomacromolecules. 2024 Feb 12;25(2):754-766. doi: 10.1021/acs.biomac.3c00943. Epub 2024 Jan 24.ABSTRACTAs current chemo- and photodynamic cancer therapies are associated with severe side effects due to a lack of specificity and to systemic toxicity, innovative solutions in terms of targeting and controlled functionality are in high demand. Here, we present the development of a polymersome nanocarrier equipped with targeting molecules and loaded with photosensitizers for efficient uptake and light-activated cell killing. Polymersomes were self-assembled in the presence of photosensitizers from a mixture of nonfunctionalize...
Source: Biomacromolecules - January 24, 2024 Category: Biochemistry Authors: Michal Skowicki Dimitri H ürlimann Shabnam Tarvirdipour Myrto Kyropoulou Cora-Ann Schoenenberger Sandrine Gerber-Lemaire Cornelia G Palivan Source Type: research
Multivalent Fluorinated Nanorings for On-Cell < sup > 19 < /sup > F NMR
Biomacromolecules. 2024 Feb 12;25(2):1330-1339. doi: 10.1021/acs.biomac.3c01391. Epub 2024 Jan 22.ABSTRACTThe design of imaging agents with a high fluorine content is necessary for overcoming the challenges of low sensitivity in 19F magnetic resonance imaging (MRI)-based molecular imaging. Chemically self-assembled nanorings (CSANs) provide a strategy to increase the fluorine content through multivalent display. We previously reported an 19F NMR-based imaging tracer, in which case a CSAN-compatible epidermal growth factor receptor (EGFR)-targeting protein E1-dimeric dihydrofolate (E1-DD) was bioconjugated to a highly fluor...
Source: Biomacromolecules - January 23, 2024 Category: Biochemistry Authors: Jiaqian Li Yiao Wang Mark D Distefano Carston R Wagner William C K Pomerantz Source Type: research
