Increased tumor-infiltrating plasmacytoid dendritic cells express high levels of PD-L2 and affect CD8 < sup > + < /sup > T lymphocyte infiltration in human laryngeal squamous cell carcinoma
In this study, flow cytometric analyses were conducted to characterize the infiltration of dendritic cells and T lymphocytes, along with their respective subgroups in tumor tissues (TT), para-carcinoma tissues (PT), and peripheral blood (PB) from LSCC patients. Immunohistochemical staining for CD4 and CD8, as well as immunofluorescence staining for CD123, were performed on serial tissue sections to investigate the co-localization of TI-pDC and tumor-infiltrating T lymphocytes (TIL) within the tumor microenvironment (TME). Our results demonstrated significantly lower percentages of all three DC subsets in PB compared to TT ...
Source: Translational Oncology - April 28, 2024 Category: Cancer & Oncology Authors: Yangyang Ji Yu Heng Xiaoke Zhu Duo Zhang Di Tang Jian Zhou Hanqing Lin Jingyu Ma Xuping Ding Lei Tao Liming Lu Source Type: research
Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression
Immunopharmacol Immunotoxicol. 2024 Apr 28:1-10. doi: 10.1080/08923973.2024.2347315. Online ahead of print.ABSTRACTUp-regulating programmed cell death ligand-1(PD-L1) expressed on tumor cells and tumor-infiltrating myeloid cells interacting with up-regulated programmed cell death-1 (PD-1) expressed on tumor-infiltrating lymphoid cells greatly hinder their tumor-inhibiting effect. It is necessary to explore the deep mechanism of this negative effect, so as to find the potential methods to improve the immunotherapy efficiency. Here, we found that the PD-1 expression in lung cancer-infiltrating type II innate lymphoid cells (...
Source: Immunopharmacology and Immunotoxicology - April 28, 2024 Category: Allergy & Immunology Authors: Chaoyun Yin Yani Pa Guangyu Li Qiang Chen Xizu Wang Xijun He Huangao Zhou Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
Mechanistic role of pyroptosis in tumor microenvironment and tumor immunotherapy
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):260-267. doi: 10.14715/cmb/2024.70.4.41.ABSTRACTIn recent decades, extraordinary attention has been devoted to cell death pathways principally because of multifaceted regulatory roles in normal developmental and pathophysiological processes. The removal of functionally defective, infected or potentially malignant cells is regulated by programmed cell death (PCD) cascades. Pyroptotic cell death is a highly complicated pro-inflammatory form of cell death. Pyroptosis is characterized by the formation of pores in the plasma membrane by oligomerization of the N-terminal fragment...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Rukset Attar Muhammad Zahid Qureshi Uteuliyev Yerzhan Sabitaliyevich Ishmuratova Margarita Yulaevna Mirna Azalea Romero Source Type: research
MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients
In conclusion, the pan-cancer study indicates that MAL with excellent prognostic value is a potential immunotherapy target in multiple cancers.PMID:38678596 | DOI:10.14715/cmb/2024.70.4.39 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Ruinian Zheng Biao Yao Yongkang Ye Ruijuan Luo Zhiming Wu Xiarong Hu Yinjiao Yuan Xuebing Pan Caixiang Liu Linxuan Huang Yongmei Luo Dan Yang NiYa Shang Yamin Tian Jun Jia Source Type: research
A novel mitochondrial unfolded protein response-related risk signature to predict prognosis, immunotherapy and sorafenib sensitivity in hepatocellular carcinoma
AbstractHepatocellular carcinoma (HCC) is a common cause of cancer-associated death worldwide. The mitochondrial unfolded protein response (UPRmt) not only maintains mitochondrial integrity but also regulates cancer progression and drug resistance. However, no study has used the UPRmt to construct a prognostic signature for HCC. This work aimed to establish a novel signature for predicting patient prognosis, immune cell infiltration, immunotherapy, and chemotherapy response based on UPRmt-related genes (MRGs). Transcriptional profiles and clinical information were obtained from the TCGA and ICGC databases. Cox regression a...
Source: Apoptosis - April 28, 2024 Category: Molecular Biology Source Type: research
High serum sodium predicts immunotherapy response in metastatic renal cell and urothelial carcinoma
The development of reliable biomarkers for the prediction of immune checkpoint inhibition (ICI) response in patients with metastatic renal cell carcinoma (mRCC) and urothelial carcinoma (mUC) remains an unresolved challenge. Conventional ICI biomarkers typically focus on tumor-related factors such as PD-L1 expression. However, a comprehensive evaluation of the predictive value of serum electrolyte levels, a so far widely unexplored area, is still pending. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 28, 2024 Category: Cancer & Oncology Authors: KlumperNiklas Kl ümper, Alexander Cox, Markus Eckstein, Christoph Kuppe, Manuel Ritter, Peter Brossart, Julian Luetkens, HolzelMichael Hölzel, Johannes Stein, Jonas Saal Tags: Original Research Source Type: research
Cancers, Vol. 16, Pages 1719: The Role of Surgery in Pleural Mesothelioma
ler
Surgery plays a central role in the diagnosis, staging, and management of pleural mesothelioma. Achieving an accurate diagnosis through surgical intervention and identifying the specific histologic subtype is crucial for determining the appropriate course of treatment. The histologic subtype guides decisions regarding the use of chemotherapy, immunotherapy, or multimodality treatment. The goal of surgery as part of multimodality treatment is to accomplish macroscopic complete resection with the eradication of grossly visible and palpable disease. Over the past two decades, many medical centers worldwide have shifte...
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Moshe Lapidot Martin Sattler Tags: Review Source Type: research
Management of Oligometastatic Colorectal Cancer
Surg Clin North Am. 2024 Jun;104(3):619-629. doi: 10.1016/j.suc.2023.11.011. Epub 2023 Dec 11.ABSTRACTThe management of oligometastatic colorectal cancer differs from the treatment of metastatic colorectal cancer, and it is essential that those who treat oligometastatic disease be familiar with the treatment options for these patients. Although definitive treatment is often surgical, there are situations where local therapies such as SBRT or ablative techniques may better serve the patient. Adjuvant therapy should be provided to all patients, and neoadjuvant chemotherapy should be considered as well. The role of immunother...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Camille R Suydam Andrew T Schlussel Source Type: research
Management of Oligometastatic Colorectal Cancer
Surg Clin North Am. 2024 Jun;104(3):619-629. doi: 10.1016/j.suc.2023.11.011. Epub 2023 Dec 11.ABSTRACTThe management of oligometastatic colorectal cancer differs from the treatment of metastatic colorectal cancer, and it is essential that those who treat oligometastatic disease be familiar with the treatment options for these patients. Although definitive treatment is often surgical, there are situations where local therapies such as SBRT or ablative techniques may better serve the patient. Adjuvant therapy should be provided to all patients, and neoadjuvant chemotherapy should be considered as well. The role of immunother...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Camille R Suydam Andrew T Schlussel Source Type: research
Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance
Comb Chem High Throughput Screen. 2024 Apr 25. doi: 10.2174/0113862073296206240416060154. Online ahead of print.ABSTRACTChemotherapy resistance is a common cause of tumor treatment failure. Various molecular responses, such as increased expression of efflux transporter proteins, including Pglycoprotein (P-gp), changes in the tumor microenvironment (TME), the role of platelets, and the effects of cancer stem cells (CSCs), can lead to drug resistance. Through extensive research on the mechanisms of drug resistance, more effective anti-resistance drugs and therapeutic approaches are being developed. This review explores drug ...
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yun Liu Xinyu Sun Chen Wei Shoudong Guo Chunxiao Song Jiangyu Zhang Jingkun Bai Source Type: research
Clostridioides difficile infection in inflammatory bowel disease: a clinical review
Expert Rev Anti Infect Ther. 2024 May 2:1-10. doi: 10.1080/14787210.2024.2347955. Online ahead of print.ABSTRACTINTRODUCTION: Strong clinical data demonstrate that inflammatory bowel disease (IBD) is an independent risk factor for Clostridiodes difficile infection (CDI) and suggest a globally increased prevalence and severity of C. difficile coinfection in IBD patients (CDI-IBD). In addition to elderly individuals, children are also at higher risk of CDI-IBD. Rapid diagnosis is essential since the clinical manifestations of active IBD and CDI-IBD are indistinguishable. Antibiotics have been well established in the treatmen...
Source: Expert Review of Anti-Infective Therapy - April 27, 2024 Category: Infectious Diseases Authors: Mengjun Tang Chunhua Wang Ying Xia Jian Tang Jiao Wang Liang Shen Source Type: research
Management of Oligometastatic Colorectal Cancer
Surg Clin North Am. 2024 Jun;104(3):619-629. doi: 10.1016/j.suc.2023.11.011. Epub 2023 Dec 11.ABSTRACTThe management of oligometastatic colorectal cancer differs from the treatment of metastatic colorectal cancer, and it is essential that those who treat oligometastatic disease be familiar with the treatment options for these patients. Although definitive treatment is often surgical, there are situations where local therapies such as SBRT or ablative techniques may better serve the patient. Adjuvant therapy should be provided to all patients, and neoadjuvant chemotherapy should be considered as well. The role of immunother...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Camille R Suydam Andrew T Schlussel Source Type: research
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review
Expert Rev Anti Infect Ther. 2024 Apr 27. doi: 10.1080/14787210.2024.2347955. Online ahead of print.ABSTRACTINTRODUCTION: Strong clinical data demonstrate that inflammatory bowel disease (IBD) is an independent risk factor for Clostridiodes difficile infection (CDI) and suggest a globally increased prevalence and severity of C. difficile coinfection in IBD patients (CDI-IBD). In addition to elderly individuals, children are also at higher risk of CDI-IBD. Rapid diagnosis is essential since the clinical manifestations of active IBD and CDI-IBD are indistinguishable. Antibiotics have been well established in the treatment of...
Source: Expert Review of Anti-Infective Therapy - April 27, 2024 Category: Infectious Diseases Authors: Mengjun Tang Chunhua Wang Ying Xia Jian Tang Jiao Wang Liang Shen Source Type: research
Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance
Comb Chem High Throughput Screen. 2024 Apr 25. doi: 10.2174/0113862073296206240416060154. Online ahead of print.ABSTRACTChemotherapy resistance is a common cause of tumor treatment failure. Various molecular responses, such as increased expression of efflux transporter proteins, including Pglycoprotein (P-gp), changes in the tumor microenvironment (TME), the role of platelets, and the effects of cancer stem cells (CSCs), can lead to drug resistance. Through extensive research on the mechanisms of drug resistance, more effective anti-resistance drugs and therapeutic approaches are being developed. This review explores drug ...
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yun Liu Xinyu Sun Chen Wei Shoudong Guo Chunxiao Song Jiangyu Zhang Jingkun Bai Source Type: research
