Clinical efficacy and safety of novel lipoglycopeptides in the treatment of acute bacterial skin and skin structure infections: A systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: Lipoglycopeptides can achieve similar clinical and microbiological responses to other comparators in treating ABSSSIs. In addition, lipoglycopeptides are as tolerable as their comparators.PMID:34550853 | DOI:10.1080/14787210.2022.1984880 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 22, 2021 Category: Infectious Diseases Authors: Chi-Kuei Hsu Ching-Yi Chen Wang-Chun Chen Chien-Ming Chao Chih-Cheng Lai Source Type: research

Janus kinase (JAK)-inhibitors and coronavirus disease 2019 (Covid-19) outcomes: a systematic review and meta-analysis
This study sought to analyze the efficacy of JAK-inhibitors to ameliorate the outcomes of Covid-19 sufferer.Research design and methods: Using specific keywords, we comprehensively go through the potential articles on ClinicalTrials.gov, Europe PMC, and PubMed sources until June 2nd, 2021. All published studies on JAK-inhibitors and Covid-19 were collected. We were using Review Manager 5.4 software to conducted statistical analysis.RESULTS: There were 14 studies with 4,363 Covid-19 patients contained in the meta-analysis. Based on our data, we suggested that JAK-inhibitors corresponded with increased recovery rate (RR 1.17...
Source: Expert Review of Anti-Infective Therapy - September 20, 2021 Category: Infectious Diseases Authors: Ronal Yosua Limen Rudyanto Sedono Adhrie Sugiarto Timotius Ivan Hariyanto Source Type: research

An evidence-based multidisciplinary approach focused at creating algorithms for targeted therapy of IVACs caused by Enterobacterales in critically ill adult patients
Expert Rev Anti Infect Ther. 2021 Sep 7. doi: 10.1080/14787210.2021.1976145. Online ahead of print.ABSTRACTINTRODUCTION: The prompt implementation of appropriate targeted antibiotic therapy represents a valuable approach in improving clinical and ecological outcome in critically septic patients. This multidisciplinary opinion article aims to develop evidence-based algorithms for targeted antibiotic therapy of infection-related ventilator associated complications (IVACs) caused by Enterobacterales, which are among the most common pathogens associated with these conditions.AREAS COVERED: A multidisciplinary team of four expe...
Source: Expert Review of Anti-Infective Therapy - September 7, 2021 Category: Infectious Diseases Authors: Milo Gatti Bruno Viaggi Gian Maria Rossolini Federico Pea Pierluigi Viale Source Type: research

Detection of SARS-CoV-2 by antigen ELISA test is highly swayed by viral load and sample storage condition
CONCLUSION: The results indicate the necessity of early infection phase diagnosis and lower temperature preservation of samples to perform rapid antigen ELISA tests.PMID:34477019 | DOI:10.1080/14787210.2021.1976144 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 3, 2021 Category: Infectious Diseases Authors: Nihad Adnan Shahad Saif Khandker Ahsanul Haq Mousumi Akter Chaity Abdul Khalek Anawarul Quader Nazim Taku Kaitsuka Kazuhito Tomizawa Masayasu Mie Eiry Kobatake Sohel Ahmed Nor Azlina A Rahman Mohib Ullah Khondoker Mainul Haque Mohd Raeed Jamiruddin Source Type: research

Accuracy of gradient diffusion method for susceptibility testing of dalbavancin and comparators
CONCLUSIONS: GD appears as an acceptable and convenient alternative for dalbavancin, vancomycin, and teicoplanin MICs determination. Our study also emphasizes how achieving accurate daptomycin MICs remains challenging.PMID:34469266 | DOI:10.1080/14787210.2021.1976143 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 1, 2021 Category: Infectious Diseases Authors: A G Leroy V Lavigne-Quilichini P Le Turnier B Loufti E Le Breton C Piau M Kempf A Pantel M Amara C Neuwirth R Sanchez J Guinard J F Huon M Gr égoire S Corvec Source Type: research

Improving empiric antibiotic prescribing in paediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA)
CONCLUSIONS: A WISCA is a data-driven, clinically intuitive tool that can be used to compare empiric antibiotic regimens for paediatric sepsis using existing large datasets. The estimates can be further refined using more complex meta-analytical methods, and patient characteristics.PMID:34424116 | DOI:10.1080/14787210.2021.1967145 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 23, 2021 Category: Infectious Diseases Authors: Aislinn Cook Mike Sharland Yasmine Yau Julia Bielicki Source Type: research

Novel strategies to diagnose Prosthetic or native Bone and joint infections
Expert Rev Anti Infect Ther. 2021 Aug 13. doi: 10.1080/14787210.2021.1967745. Online ahead of print.ABSTRACTINTRODUCTION: Bone and Joint Infections (BJI) are medically important, costly and occur in both native and prosthetic joints. Arthroplasties are expected to increase significantly in absolute numbers over time as well as the incidence of Prosthetic Joint Infections (PJI). Diagnosis of BJI and PJI is generally sub-optimal. The available diagnostic tests have variable effectiveness, are often below standard in sensitivity and/or specificity and carry a significant contamination risk during the collection of clinical sa...
Source: Expert Review of Anti-Infective Therapy - August 13, 2021 Category: Infectious Diseases Authors: Alex van Belkum Marie-Francoise Gros Tristan Ferry Sebastien Lustig Fr édéric Laurent Geraldine Durand Corinne Jay Olivier Rochas Christine C Ginocchio Source Type: research

< em > Clostridioides difficile < /em > infection: an emerging zoonosis?
Expert Rev Anti Infect Ther. 2021 Aug 12. doi: 10.1080/14787210.2021.1967746. Online ahead of print.ABSTRACTINTRODUCTION: Clostridioides difficile (C. difficile) infection (CDI) is the most common cause of antibiotic-associated diarrhea and one of the common infections in healthcare facilities. In recent decades, there has been an emerging threat of community-acquired CDI (CA-CDI). Environmental transmission of C. difficile in the community setting has become a major concern, and animals are an important reservoir for C. difficile causing human diseases.AREAS COVERED: In this article, the molecular epidemiology of C. diffi...
Source: Expert Review of Anti-Infective Therapy - August 12, 2021 Category: Infectious Diseases Authors: Chin-Shiang Tsai Yuan-Pin Hung Jen-Chieh Lee Ling-Shan Syue Po-Ren Hsueh Wen-Chien Ko Source Type: research

The effects of the pandemic in cases of heart failure
Expert Rev Anti Infect Ther. 2021 Aug 5. doi: 10.1080/14787210.2021.1964360. Online ahead of print.NO ABSTRACTPMID:34353200 | DOI:10.1080/14787210.2021.1964360 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 6, 2021 Category: Infectious Diseases Authors: Gustavo Teixeira Bristot Nikolas de Vargas Raupp Eliane Mazzuco Dos Santos Elonir Gomes Source Type: research

T2MR can be used as a non-culture-based test together with biomarkers to improve detection of < em > Candida < /em > in the bloodstream and reduce time delay in treating invasive candidiasis
Expert Rev Anti Infect Ther. 2021 Aug 6. doi: 10.1080/14787210.2021.1964954. Online ahead of print.NO ABSTRACTPMID:34357835 | DOI:10.1080/14787210.2021.1964954 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 6, 2021 Category: Infectious Diseases Authors: Patrick M Honore Sebastien Redant Thierry Preseau Sofie Moorthamers Keitiane Kaefer Leonel Barreto Gutierrez Rachid Attou Andrea Gallerani David De Bels Source Type: research

The effects of the pandemic in cases of heart failure
Expert Rev Anti Infect Ther. 2021 Aug 5. doi: 10.1080/14787210.2021.1964360. Online ahead of print.NO ABSTRACTPMID:34353200 | DOI:10.1080/14787210.2021.1964360 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 6, 2021 Category: Infectious Diseases Authors: Gustavo Teixeira Bristot Nikolas de Vargas Raupp Eliane Mazzuco Dos Santos Elonir Gomes Source Type: research

T2MR can be used as a non-culture-based test together with biomarkers to improve detection of < em > Candida < /em > in the bloodstream and reduce time delay in treating invasive candidiasis
Expert Rev Anti Infect Ther. 2021 Aug 6. doi: 10.1080/14787210.2021.1964954. Online ahead of print.NO ABSTRACTPMID:34357835 | DOI:10.1080/14787210.2021.1964954 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 6, 2021 Category: Infectious Diseases Authors: Patrick M Honore Sebastien Redant Thierry Preseau Sofie Moorthamers Keitiane Kaefer Leonel Barreto Gutierrez Rachid Attou Andrea Gallerani David De Bels Source Type: research

The effects of the pandemic in cases of heart failure
Expert Rev Anti Infect Ther. 2021 Aug 5. doi: 10.1080/14787210.2021.1964360. Online ahead of print.NO ABSTRACTPMID:34353200 | DOI:10.1080/14787210.2021.1964360 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 6, 2021 Category: Infectious Diseases Authors: Gustavo Teixeira Bristot Nikolas de Vargas Raupp Eliane Mazzuco Dos Santos Elonir Gomes Source Type: research

T2MR can be used as a non-culture-based test together with biomarkers to improve detection of < em > Candida < /em > in the bloodstream and reduce time delay in treating invasive candidiasis
Expert Rev Anti Infect Ther. 2021 Aug 6. doi: 10.1080/14787210.2021.1964954. Online ahead of print.NO ABSTRACTPMID:34357835 | DOI:10.1080/14787210.2021.1964954 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 6, 2021 Category: Infectious Diseases Authors: Patrick M Honore Sebastien Redant Thierry Preseau Sofie Moorthamers Keitiane Kaefer Leonel Barreto Gutierrez Rachid Attou Andrea Gallerani David De Bels Source Type: research

The effects of the pandemic in cases of heart failure
Expert Rev Anti Infect Ther. 2021 Aug 5. doi: 10.1080/14787210.2021.1964360. Online ahead of print.NO ABSTRACTPMID:34353200 | DOI:10.1080/14787210.2021.1964360 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 6, 2021 Category: Infectious Diseases Authors: Gustavo Teixeira Bristot Nikolas de Vargas Raupp Eliane Mazzuco Dos Santos Elonir Gomes Source Type: research

T2MR can be used as a non-culture-based test together with biomarkers to improve detection of < em > Candida < /em > in the bloodstream and reduce time delay in treating invasive candidiasis
Expert Rev Anti Infect Ther. 2021 Aug 6. doi: 10.1080/14787210.2021.1964954. Online ahead of print.NO ABSTRACTPMID:34357835 | DOI:10.1080/14787210.2021.1964954 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 6, 2021 Category: Infectious Diseases Authors: Patrick M Honore Sebastien Redant Thierry Preseau Sofie Moorthamers Keitiane Kaefer Leonel Barreto Gutierrez Rachid Attou Andrea Gallerani David De Bels Source Type: research

The effects of the pandemic in cases of heart failure
Expert Rev Anti Infect Ther. 2021 Aug 5. doi: 10.1080/14787210.2021.1964360. Online ahead of print.NO ABSTRACTPMID:34353200 | DOI:10.1080/14787210.2021.1964360 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 6, 2021 Category: Infectious Diseases Authors: Gustavo Teixeira Bristot Nikolas de Vargas Raupp Eliane Mazzuco Dos Santos Elonir Gomes Source Type: research

Current and emerging strategies to combat antimalarial resistance
Expert Rev Anti Infect Ther. 2021 Aug 5. doi: 10.1080/14787210.2021.1962291. Online ahead of print.ABSTRACTINTRODUCTION: Since the spread of chloroquine resistance in Plasmodium falciparum in the 1960s, recommendations have been made on how to respond to antimalarial resistance. Only with the advent of artemisinin partial resistance were large scale efforts made in the Greater Mekong Subregion to carry out recommendations in a coordinated and well-funded manner. Independent emergence of parasites partially resistant to artemisinins has now been reported in Rwanda.AREAS COVERED: We reviewed past recommendations and activiti...
Source: Expert Review of Anti-Infective Therapy - August 5, 2021 Category: Infectious Diseases Authors: Charlotte Rasmussen Pedro Alonso Pascal Ringwald Source Type: research

Anti-inflammatory Effects of GLP-1 in Patients with COVID-19
Expert Rev Anti Infect Ther. 2021 Aug 4. doi: 10.1080/14787210.2021.1964955. Online ahead of print.ABSTRACTUnderstanding the pathogenesis and risk factors to control the coronavirus disease 2019 (COVID-19) is necessary. Due to the importance of the inflammatory pathways in the pathogenesis of COVID-19 patients, evaluating the effects of anti-inflammatory medications is important. Glucagon-like peptide 1 receptor agonist (GLP-1RA) is a well-known glucose-lowering agent with anti-inflammatory effects.Areas covered:Resources were extracted from the PubMed database, using keywords such as glucagon-like peptide-1, GLP-1RA, SARS...
Source: Expert Review of Anti-Infective Therapy - August 4, 2021 Category: Infectious Diseases Authors: Saharnaz Sazgarnejad Niloufar Yazdanpanah Nima Rezaei Source Type: research

Cardiovascular complications of COVID-19: towards better understanding, diagnosis, monitoring and management
Expert Rev Anti Infect Ther. 2021 Aug 3. doi: 10.1080/14787210.2021.1964695. Online ahead of print.NO ABSTRACTPMID:34343449 | DOI:10.1080/14787210.2021.1964695 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - August 3, 2021 Category: Infectious Diseases Authors: Marco Vicenzi Massimiliano Ruscica Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research

Pharmacological management of antifungal agents in pulmonary aspergillosis: an updated review
This article reviews the pharmacology of antifungal agents in development and currently used to treat pulmonary aspergillosis, including the mechanisms of action, pharmacokinetics, pharmacodynamics, dosing, therapeutic drug monitoring and safety. Recommendations to manage situations that arise in daily clinical practice are provided. A literature search of PubMed was conducted on November 15th, 2020 and updated on March 30th, 2021.EXPERT OPINION: Recent and relevant developments in the treatment of pulmonary aspergillosis have taken place. Novel antifungals with new mechanisms of action that extend antifungal spectrum and ...
Source: Expert Review of Anti-Infective Therapy - July 30, 2021 Category: Infectious Diseases Authors: Daniel Echeverria-Esnal Clara Mart ín-Ontiyuelo Maria Eugenia Navarrete-Rouco Jaime Barcelo-Vidal David Conde-Est évez Nuria Carballo Marta De-Antonio Cusc ó Olivia Ferr ández Juan Pablo Horcajada Santiago Grau Source Type: research