Diagnosis, prevention, and treatment of coronavirus disease: a review
Expert Rev Anti Infect Ther. 2021 Jun 19. doi: 10.1080/14787210.2021.1944103. Online ahead of print.ABSTRACTINTRODUCTION: Coronavirus disease (COVID-19) was first reported in Wuhan, China, in late December 2019 and subsequently, declared a pandemic. As of 3rd June, 2021, 172,493,290 individuals have acquired COVID-19 and 3,708,334 patients have died worldwide, according to the World Health Organization.AREAS COVERED: This review explores epidemiology; virology; pathogenesis; genomic variations; mode of transmission; clinical occurrence; diagnosis; and treatment with antiviral agents, antibiotics, and supportive therapies. ...
Source: Expert Review of Anti-Infective Therapy - June 21, 2021 Category: Infectious Diseases Authors: Manoj Kumar Sarangi Sasmita Padhi Shrivardhan Dheeman Santosh Kumar Karn L D Patel Dong Kee Yi Sitansu Sekhar Nanda Source Type: research

Proposed amendments regarding the definitions of multidrug-resistant and extensively drug-resistant bacteria
Expert Rev Anti Infect Ther. 2021 Jun 21. doi: 10.1080/14787210.2021.1945922. Online ahead of print.ABSTRACTINTRODUCTION: It is fortunate that an international panel of experts proposed definitions for multidrug-resistant (MDR) and extensively drug-resistant (XDR) in the past.AREAS COVERED: In our opinion these definitions need amendments in order to be semantically more accurate.EXPERT OPINION: We suggest for the MDR definition to add to "MDR is defined as non-susceptibility to at least one agent in three or more antimicrobial categories" that this non-susceptibility is at most to the total number of all antimic...
Source: Expert Review of Anti-Infective Therapy - June 21, 2021 Category: Infectious Diseases Authors: Petros I Rafailidis Diamantis Kofteridis Source Type: research

Diagnosis, prevention, and treatment of coronavirus disease: a review
Expert Rev Anti Infect Ther. 2021 Jun 19. doi: 10.1080/14787210.2021.1944103. Online ahead of print.ABSTRACTINTRODUCTION: Coronavirus disease (COVID-19) was first reported in Wuhan, China, in late December 2019 and subsequently, declared a pandemic. As of 3rd June, 2021, 172,493,290 individuals have acquired COVID-19 and 3,708,334 patients have died worldwide, according to the World Health Organization.AREAS COVERED: This review explores epidemiology; virology; pathogenesis; genomic variations; mode of transmission; clinical occurrence; diagnosis; and treatment with antiviral agents, antibiotics, and supportive therapies. ...
Source: Expert Review of Anti-Infective Therapy - June 21, 2021 Category: Infectious Diseases Authors: Manoj Kumar Sarangi Sasmita Padhi Shrivardhan Dheeman Santosh Kumar Karn L D Patel Dong Kee Yi Sitansu Sekhar Nanda Source Type: research

Proposed amendments regarding the definitions of multidrug-resistant and extensively drug-resistant bacteria
Expert Rev Anti Infect Ther. 2021 Jun 21. doi: 10.1080/14787210.2021.1945922. Online ahead of print.ABSTRACTINTRODUCTION: It is fortunate that an international panel of experts proposed definitions for multidrug-resistant (MDR) and extensively drug-resistant (XDR) in the past.AREAS COVERED: In our opinion these definitions need amendments in order to be semantically more accurate.EXPERT OPINION: We suggest for the MDR definition to add to "MDR is defined as non-susceptibility to at least one agent in three or more antimicrobial categories" that this non-susceptibility is at most to the total number of all antimic...
Source: Expert Review of Anti-Infective Therapy - June 21, 2021 Category: Infectious Diseases Authors: Petros I Rafailidis Diamantis Kofteridis Source Type: research

Diagnosis, prevention, and treatment of coronavirus disease: a review
Expert Rev Anti Infect Ther. 2021 Jun 19. doi: 10.1080/14787210.2021.1944103. Online ahead of print.ABSTRACTINTRODUCTION: Coronavirus disease (COVID-19) was first reported in Wuhan, China, in late December 2019 and subsequently, declared a pandemic. As of 3rd June, 2021, 172,493,290 individuals have acquired COVID-19 and 3,708,334 patients have died worldwide, according to the World Health Organization.AREAS COVERED: This review explores epidemiology; virology; pathogenesis; genomic variations; mode of transmission; clinical occurrence; diagnosis; and treatment with antiviral agents, antibiotics, and supportive therapies. ...
Source: Expert Review of Anti-Infective Therapy - June 21, 2021 Category: Infectious Diseases Authors: Manoj Kumar Sarangi Sasmita Padhi Shrivardhan Dheeman Santosh Kumar Karn L D Patel Dong Kee Yi Sitansu Sekhar Nanda Source Type: research

A multicentre point prevalence study of antibiotics utilization in hospitalised patients in an urban secondary and a tertiary healthcare facilities in Nigeria: findings and implications
CONCLUSIONS: There is high rate of antibiotics utilization in these facilities with lack of institutional frameworks and processes for ensuring appropriate antibiotic use. The study provides the information needed to improve future antimicrobial use in hospitals and reduce AMR.PMID:34128756 | DOI:10.1080/14787210.2021.1941870 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Olayinka O Ogunleye Modupe R Oyawole Patricia T Odunuga Folasade Kalejaye Adesola F Yinka-Ogunleye Adesola Olalekan Sunday O Ogundele Bernard E Ebruke Atinuke Kalada Richard Bene D Anand Paramadhas Amanj Kurdi Jacqueline Sneddon Andrew Seaton Brian Godman Source Type: research

The antifungal activity of caspofungin in combination with antifungals or non-antifungals against < em > Candida < /em > species < em > in vitro < /em > and in clinical therapy
Expert Rev Anti Infect Ther. 2021 Jun 15. doi: 10.1080/14787210.2021.1941868. Online ahead of print.ABSTRACTINTRODUCTION: Candida species have been regarded as global health threats due to their ability to cause invasive infections. It is challenging to treat Candida bloodstream infections, which are associated with high mortality levels. Monotherapy with antifungals is sometimes not effective against severe Candida infections, and combination therapy is needed in clinical practice.AREAS COVERED: This review was undertaken based on data from a PubMed search for English language reports published before March 2021 by using ...
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Shan Su Haiying Yan Li Min Hongmei Wang Xueqi Chen Jinyi Shi Shujuan Sun Source Type: research

A multicentre point prevalence study of antibiotics utilization in hospitalised patients in an urban secondary and a tertiary healthcare facilities in Nigeria: findings and implications
CONCLUSIONS: There is high rate of antibiotics utilization in these facilities with lack of institutional frameworks and processes for ensuring appropriate antibiotic use. The study provides the information needed to improve future antimicrobial use in hospitals and reduce AMR.PMID:34128756 | DOI:10.1080/14787210.2021.1941870 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Olayinka O Ogunleye Modupe R Oyawole Patricia T Odunuga Folasade Kalejaye Adesola F Yinka-Ogunleye Adesola Olalekan Sunday O Ogundele Bernard E Ebruke Atinuke Kalada Richard Bene D Anand Paramadhas Amanj Kurdi Jacqueline Sneddon Andrew Seaton Brian Godman Source Type: research

The antifungal activity of caspofungin in combination with antifungals or non-antifungals against < em > Candida < /em > species < em > in vitro < /em > and in clinical therapy
Expert Rev Anti Infect Ther. 2021 Jun 15. doi: 10.1080/14787210.2021.1941868. Online ahead of print.ABSTRACTINTRODUCTION: Candida species have been regarded as global health threats due to their ability to cause invasive infections. It is challenging to treat Candida bloodstream infections, which are associated with high mortality levels. Monotherapy with antifungals is sometimes not effective against severe Candida infections, and combination therapy is needed in clinical practice.AREAS COVERED: This review was undertaken based on data from a PubMed search for English language reports published before March 2021 by using ...
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Shan Su Haiying Yan Li Min Hongmei Wang Xueqi Chen Jinyi Shi Shujuan Sun Source Type: research

A multicentre point prevalence study of antibiotics utilization in hospitalised patients in an urban secondary and a tertiary healthcare facilities in Nigeria: findings and implications
CONCLUSIONS: There is high rate of antibiotics utilization in these facilities with lack of institutional frameworks and processes for ensuring appropriate antibiotic use. The study provides the information needed to improve future antimicrobial use in hospitals and reduce AMR.PMID:34128756 | DOI:10.1080/14787210.2021.1941870 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Olayinka O Ogunleye Modupe R Oyawole Patricia T Odunuga Folasade Kalejaye Adesola F Yinka-Ogunleye Adesola Olalekan Sunday O Ogundele Bernard E Ebruke Atinuke Kalada Richard Bene D Anand Paramadhas Amanj Kurdi Jacqueline Sneddon Andrew Seaton Brian Godman Source Type: research

The antifungal activity of caspofungin in combination with antifungals or non-antifungals against < em > Candida < /em > species < em > in vitro < /em > and in clinical therapy
Expert Rev Anti Infect Ther. 2021 Jun 15. doi: 10.1080/14787210.2021.1941868. Online ahead of print.ABSTRACTINTRODUCTION: Candida species have been regarded as global health threats due to their ability to cause invasive infections. It is challenging to treat Candida bloodstream infections, which are associated with high mortality levels. Monotherapy with antifungals is sometimes not effective against severe Candida infections, and combination therapy is needed in clinical practice.AREAS COVERED: This review was undertaken based on data from a PubMed search for English language reports published before March 2021 by using ...
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Shan Su Haiying Yan Li Min Hongmei Wang Xueqi Chen Jinyi Shi Shujuan Sun Source Type: research

A multicentre point prevalence study of antibiotics utilization in hospitalised patients in an urban secondary and a tertiary healthcare facilities in Nigeria: findings and implications
CONCLUSIONS: There is high rate of antibiotics utilization in these facilities with lack of institutional frameworks and processes for ensuring appropriate antibiotic use. The study provides the information needed to improve future antimicrobial use in hospitals and reduce AMR.PMID:34128756 | DOI:10.1080/14787210.2021.1941870 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Olayinka O Ogunleye Modupe R Oyawole Patricia T Odunuga Folasade Kalejaye Adesola F Yinka-Ogunleye Adesola Olalekan Sunday O Ogundele Bernard E Ebruke Atinuke Kalada Richard Bene D Anand Paramadhas Amanj Kurdi Jacqueline Sneddon Andrew Seaton Brian Godman Source Type: research

The antifungal activity of caspofungin in combination with antifungals or non-antifungals against < em > Candida < /em > species < em > in vitro < /em > and in clinical therapy
Expert Rev Anti Infect Ther. 2021 Jun 15. doi: 10.1080/14787210.2021.1941868. Online ahead of print.ABSTRACTINTRODUCTION: Candida species have been regarded as global health threats due to their ability to cause invasive infections. It is challenging to treat Candida bloodstream infections, which are associated with high mortality levels. Monotherapy with antifungals is sometimes not effective against severe Candida infections, and combination therapy is needed in clinical practice.AREAS COVERED: This review was undertaken based on data from a PubMed search for English language reports published before March 2021 by using ...
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Shan Su Haiying Yan Li Min Hongmei Wang Xueqi Chen Jinyi Shi Shujuan Sun Source Type: research

A multicentre point prevalence study of antibiotics utilization in hospitalised patients in an urban secondary and a tertiary healthcare facilities in Nigeria: findings and implications
CONCLUSIONS: There is high rate of antibiotics utilization in these facilities with lack of institutional frameworks and processes for ensuring appropriate antibiotic use. The study provides the information needed to improve future antimicrobial use in hospitals and reduce AMR.PMID:34128756 | DOI:10.1080/14787210.2021.1941870 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Olayinka O Ogunleye Modupe R Oyawole Patricia T Odunuga Folasade Kalejaye Adesola F Yinka-Ogunleye Adesola Olalekan Sunday O Ogundele Bernard E Ebruke Atinuke Kalada Richard Bene D Anand Paramadhas Amanj Kurdi Jacqueline Sneddon Andrew Seaton Brian Godman Source Type: research

The antifungal activity of caspofungin in combination with antifungals or non-antifungals against < em > Candida < /em > species < em > in vitro < /em > and in clinical therapy
Expert Rev Anti Infect Ther. 2021 Jun 15. doi: 10.1080/14787210.2021.1941868. Online ahead of print.ABSTRACTINTRODUCTION: Candida species have been regarded as global health threats due to their ability to cause invasive infections. It is challenging to treat Candida bloodstream infections, which are associated with high mortality levels. Monotherapy with antifungals is sometimes not effective against severe Candida infections, and combination therapy is needed in clinical practice.AREAS COVERED: This review was undertaken based on data from a PubMed search for English language reports published before March 2021 by using ...
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Shan Su Haiying Yan Li Min Hongmei Wang Xueqi Chen Jinyi Shi Shujuan Sun Source Type: research

Molecular diagnosis of toxoplasmosis: recent advances and a look to the future
Expert Rev Anti Infect Ther. 2021 Jun 11. doi: 10.1080/14787210.2021.1941867. Online ahead of print.ABSTRACTINTRODUCTION: Toxoplasmosis is a globally distributed parasitic infection that can be particularly severe when opportunistic or congenital. Its diagnosis requires accurate and rapid techniques that rely mainly on serology and molecular methods.AREAS COVERED: The aim of this review was to discuss the positioning of the molecular diagnosis of toxoplasmosis according to the different clinical situations possibly resulting from infection with T. gondii, and to detail recent developments in this technique.The English and ...
Source: Expert Review of Anti-Infective Therapy - June 11, 2021 Category: Infectious Diseases Authors: Marie Gladys Robert Marie-Pierre Brenier-Pinchart C écile Garnaud H élène Fricker-Hidalgo Herv é Pelloux Source Type: research

Vitamin D attenuates COVID-19 complications via modulation of proinflammatory cytokines, antiviral proteins, and autophagy
Expert Rev Anti Infect Ther. 2021 Jun 10. doi: 10.1080/14787210.2021.1941871. Online ahead of print.ABSTRACTIntroduction: Global emergence of coronavirus disease-19 (COVID-19) has clearly shown variable severity, mortality, and frequency between and within populations worldwide. These striking differences have made many biological variables attractive for future investigations. One of these variables, vitamin D, has been implicated in COVID-19 with rapidly growing scientific evidence. Areas covered: The review intended to systematically explore the sources, and immunomodulatory the role of vitamin D in COVID-19. Search eng...
Source: Expert Review of Anti-Infective Therapy - June 11, 2021 Category: Infectious Diseases Authors: Sadaf Jamal Gilani May Bin-Jumah Muhammad Shahid Nadeem Imran Kazmi Source Type: research

Molecular diagnosis of toxoplasmosis: recent advances and a look to the future
Expert Rev Anti Infect Ther. 2021 Jun 11. doi: 10.1080/14787210.2021.1941867. Online ahead of print.ABSTRACTINTRODUCTION: Toxoplasmosis is a globally distributed parasitic infection that can be particularly severe when opportunistic or congenital. Its diagnosis requires accurate and rapid techniques that rely mainly on serology and molecular methods.AREAS COVERED: The aim of this review was to discuss the positioning of the molecular diagnosis of toxoplasmosis according to the different clinical situations possibly resulting from infection with T. gondii, and to detail recent developments in this technique.The English and ...
Source: Expert Review of Anti-Infective Therapy - June 11, 2021 Category: Infectious Diseases Authors: Marie Gladys Robert Marie-Pierre Brenier-Pinchart C écile Garnaud H élène Fricker-Hidalgo Herv é Pelloux Source Type: research

Vitamin D attenuates COVID-19 complications via modulation of proinflammatory cytokines, antiviral proteins, and autophagy
Expert Rev Anti Infect Ther. 2021 Jun 10. doi: 10.1080/14787210.2021.1941871. Online ahead of print.ABSTRACTIntroduction: Global emergence of coronavirus disease-19 (COVID-19) has clearly shown variable severity, mortality, and frequency between and within populations worldwide. These striking differences have made many biological variables attractive for future investigations. One of these variables, vitamin D, has been implicated in COVID-19 with rapidly growing scientific evidence. Areas covered: The review intended to systematically explore the sources, and immunomodulatory the role of vitamin D in COVID-19. Search eng...
Source: Expert Review of Anti-Infective Therapy - June 11, 2021 Category: Infectious Diseases Authors: Sadaf Jamal Gilani May Bin-Jumah Muhammad Shahid Nadeem Imran Kazmi Source Type: research

Molecular diagnosis of toxoplasmosis: recent advances and a look to the future
Expert Rev Anti Infect Ther. 2021 Jun 11. doi: 10.1080/14787210.2021.1941867. Online ahead of print.ABSTRACTINTRODUCTION: Toxoplasmosis is a globally distributed parasitic infection that can be particularly severe when opportunistic or congenital. Its diagnosis requires accurate and rapid techniques that rely mainly on serology and molecular methods.AREAS COVERED: The aim of this review was to discuss the positioning of the molecular diagnosis of toxoplasmosis according to the different clinical situations possibly resulting from infection with T. gondii, and to detail recent developments in this technique.The English and ...
Source: Expert Review of Anti-Infective Therapy - June 11, 2021 Category: Infectious Diseases Authors: Marie Gladys Robert Marie-Pierre Brenier-Pinchart C écile Garnaud H élène Fricker-Hidalgo Herv é Pelloux Source Type: research

Vitamin D attenuates COVID-19 complications via modulation of proinflammatory cytokines, antiviral proteins, and autophagy
Expert Rev Anti Infect Ther. 2021 Jun 10. doi: 10.1080/14787210.2021.1941871. Online ahead of print.ABSTRACTIntroduction: Global emergence of coronavirus disease-19 (COVID-19) has clearly shown variable severity, mortality, and frequency between and within populations worldwide. These striking differences have made many biological variables attractive for future investigations. One of these variables, vitamin D, has been implicated in COVID-19 with rapidly growing scientific evidence. Areas covered: The review intended to systematically explore the sources, and immunomodulatory the role of vitamin D in COVID-19. Search eng...
Source: Expert Review of Anti-Infective Therapy - June 11, 2021 Category: Infectious Diseases Authors: Sadaf Jamal Gilani May Bin-Jumah Muhammad Shahid Nadeem Imran Kazmi Source Type: research

Molecular diagnosis of toxoplasmosis: recent advances and a look to the future
Expert Rev Anti Infect Ther. 2021 Jun 11. doi: 10.1080/14787210.2021.1941867. Online ahead of print.ABSTRACTINTRODUCTION: Toxoplasmosis is a globally distributed parasitic infection that can be particularly severe when opportunistic or congenital. Its diagnosis requires accurate and rapid techniques that rely mainly on serology and molecular methods.AREAS COVERED: The aim of this review was to discuss the positioning of the molecular diagnosis of toxoplasmosis according to the different clinical situations possibly resulting from infection with T. gondii, and to detail recent developments in this technique.The English and ...
Source: Expert Review of Anti-Infective Therapy - June 11, 2021 Category: Infectious Diseases Authors: Marie Gladys Robert Marie-Pierre Brenier-Pinchart C écile Garnaud H élène Fricker-Hidalgo Herv é Pelloux Source Type: research

Vitamin D attenuates COVID-19 complications via modulation of proinflammatory cytokines, antiviral proteins, and autophagy
Expert Rev Anti Infect Ther. 2021 Jun 10. doi: 10.1080/14787210.2021.1941871. Online ahead of print.ABSTRACTIntroduction: Global emergence of coronavirus disease-19 (COVID-19) has clearly shown variable severity, mortality, and frequency between and within populations worldwide. These striking differences have made many biological variables attractive for future investigations. One of these variables, vitamin D, has been implicated in COVID-19 with rapidly growing scientific evidence. Areas covered: The review intended to systematically explore the sources, and immunomodulatory the role of vitamin D in COVID-19. Search eng...
Source: Expert Review of Anti-Infective Therapy - June 11, 2021 Category: Infectious Diseases Authors: Sadaf Jamal Gilani May Bin-Jumah Muhammad Shahid Nadeem Imran Kazmi Source Type: research

Scrub typhus and antibiotic-resistant < em > Orientia tsutsugamushi < /em >
Expert Rev Anti Infect Ther. 2021 Jun 10. doi: 10.1080/14787210.2021.1941869. Online ahead of print.ABSTRACTIntroduction: Scrub typhus is one of the most underdiagnosed and under-reported febrile illnesses requiring hospitalization, mainly occurring in Southeast and East Asia and the Pacific Islands, in an area referred to as the "Tsutsugamushi Triangle." Scrub typhus is a zoonotic rickettsial disease that is transmitted to humans by trombiculid mites.Areas covered: A MEDLINE/PubMed search of the available literature was performed to describe the role of antibiotic-resistant scrub typhus in therapy failure.Expert...
Source: Expert Review of Anti-Infective Therapy - June 10, 2021 Category: Infectious Diseases Authors: Chin-Te Lu Lih-Shinn Wang Po-Ren Hsueh Source Type: research

Efinaconazole topical solution (10%) for the treatment of onychomycosis in adult and pediatric patients
Expert Rev Anti Infect Ther. 2021 Jun 9. doi: 10.1080/14787210.2021.1939011. Online ahead of print.ABSTRACTINTRODUCTION: Onychomycosis, a common nail disorder caused by fungal infection, can be managed pharmaceutically with oral or topical treatments. While oral treatments are often used first-line to treat nail infections, these systemic antifungals are not appropriate for all patients, and no oral treatments are approved for use in children in the USA. Given this need, topical antifungals were developed, which can be used as monotherapy or in combination with oral drugs.AREAS COVERED: Efinaconazole 10% solution is an azo...
Source: Expert Review of Anti-Infective Therapy - June 9, 2021 Category: Infectious Diseases Authors: Tracey C Vlahovic Aditya K Gupta Source Type: research

NSAIDs/Nitazoxanide/Azithromycin Repurposed for COVID-19: Potential Mitigation of the Cytokine Storm Interleukin-6 Amplifier via Immunomodulatory Effects
Expert Rev Anti Infect Ther. 2021 Jun 4. doi: 10.1080/14787210.2021.1939683. Online ahead of print.ABSTRACTMediators of immunity and inflammation are playing a crucial role in COVID-19 pathogenesis and complications as demonstrated by several genetic and clinical studies. Thus, repurposing of drugs that possess anti-inflammatory and/or immune-modulatory effects for COVID-19 is considered a rational approach.Areas covered: We analyze selected studies that correlated COVID-19 with dysregulated interferon and inflammatory responses while reflecting on our academic and real-life experience using non-steroidal anti-inflammatory...
Source: Expert Review of Anti-Infective Therapy - June 5, 2021 Category: Infectious Diseases Authors: Mina T Kelleni Source Type: research

Antibiotic use among hospitalized children under-five with lower respiratory tract infections: a multicenter, retrospective study from Punjab, Pakistan
Conclusions: Current surveillance study revealed a worrying degree of antibiotic misuse among hospitalized LRTI children aged ≤ 5 years.PMID:34047247 | DOI:10.1080/14787210.2021.1935235 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Zia Ul Mustafa Muhammad Salman Naeem Aslam Noman Asif Khalid Hussain Naureen Tanveer Khezar Hayat Source Type: research

IL28B, TLR7 SNPs, and cytomegalovirus infection are risk factors for advanced liver disease in chronic hepatitis C patients
CONCLUSION: IL28B, TLR7 SNPs and cytomegalovirus infection are risk factors for advanced liver disease in hepatitis C patients.PMID:34047252 | DOI:10.1080/14787210.2021.1935239 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Fatma Omar Khalil Ayman Alsebaey Zeinab Abdelaziz Kasemy Sabry Moawad Abdelmageed Hanan Mosaad Bedair Shimaa Abdelsattar Source Type: research

Antibiotic use among hospitalized children under-five with lower respiratory tract infections: a multicenter, retrospective study from Punjab, Pakistan
Conclusions: Current surveillance study revealed a worrying degree of antibiotic misuse among hospitalized LRTI children aged ≤ 5 years.PMID:34047247 | DOI:10.1080/14787210.2021.1935235 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Zia Ul Mustafa Muhammad Salman Naeem Aslam Noman Asif Khalid Hussain Naureen Tanveer Khezar Hayat Source Type: research

IL28B, TLR7 SNPs, and cytomegalovirus infection are risk factors for advanced liver disease in chronic hepatitis C patients
CONCLUSION: IL28B, TLR7 SNPs and cytomegalovirus infection are risk factors for advanced liver disease in hepatitis C patients.PMID:34047252 | DOI:10.1080/14787210.2021.1935239 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Fatma Omar Khalil Ayman Alsebaey Zeinab Abdelaziz Kasemy Sabry Moawad Abdelmageed Hanan Mosaad Bedair Shimaa Abdelsattar Source Type: research

Antibiotic use among hospitalized children under-five with lower respiratory tract infections: a multicenter, retrospective study from Punjab, Pakistan
Conclusions: Current surveillance study revealed a worrying degree of antibiotic misuse among hospitalized LRTI children aged ≤ 5 years.PMID:34047247 | DOI:10.1080/14787210.2021.1935235 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Zia Ul Mustafa Muhammad Salman Naeem Aslam Noman Asif Khalid Hussain Naureen Tanveer Khezar Hayat Source Type: research

IL28B, TLR7 SNPs, and cytomegalovirus infection are risk factors for advanced liver disease in chronic hepatitis C patients
CONCLUSION: IL28B, TLR7 SNPs and cytomegalovirus infection are risk factors for advanced liver disease in hepatitis C patients.PMID:34047252 | DOI:10.1080/14787210.2021.1935239 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Fatma Omar Khalil Ayman Alsebaey Zeinab Abdelaziz Kasemy Sabry Moawad Abdelmageed Hanan Mosaad Bedair Shimaa Abdelsattar Source Type: research

Antibiotic use among hospitalized children under-five with lower respiratory tract infections: a multicenter, retrospective study from Punjab, Pakistan
Conclusions: Current surveillance study revealed a worrying degree of antibiotic misuse among hospitalized LRTI children aged ≤ 5 years.PMID:34047247 | DOI:10.1080/14787210.2021.1935235 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Zia Ul Mustafa Muhammad Salman Naeem Aslam Noman Asif Khalid Hussain Naureen Tanveer Khezar Hayat Source Type: research

IL28B, TLR7 SNPs, and cytomegalovirus infection are risk factors for advanced liver disease in chronic hepatitis C patients
CONCLUSION: IL28B, TLR7 SNPs and cytomegalovirus infection are risk factors for advanced liver disease in hepatitis C patients.PMID:34047252 | DOI:10.1080/14787210.2021.1935239 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Fatma Omar Khalil Ayman Alsebaey Zeinab Abdelaziz Kasemy Sabry Moawad Abdelmageed Hanan Mosaad Bedair Shimaa Abdelsattar Source Type: research

Antibiotic use among hospitalized children under-five with lower respiratory tract infections: a multicenter, retrospective study from Punjab, Pakistan
Conclusions: Current surveillance study revealed a worrying degree of antibiotic misuse among hospitalized LRTI children aged ≤ 5 years.PMID:34047247 | DOI:10.1080/14787210.2021.1935235 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Zia Ul Mustafa Muhammad Salman Naeem Aslam Noman Asif Khalid Hussain Naureen Tanveer Khezar Hayat Source Type: research

IL28B, TLR7 SNPs, and cytomegalovirus infection are risk factors for advanced liver disease in chronic hepatitis C patients
CONCLUSION: IL28B, TLR7 SNPs and cytomegalovirus infection are risk factors for advanced liver disease in hepatitis C patients.PMID:34047252 | DOI:10.1080/14787210.2021.1935239 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Fatma Omar Khalil Ayman Alsebaey Zeinab Abdelaziz Kasemy Sabry Moawad Abdelmageed Hanan Mosaad Bedair Shimaa Abdelsattar Source Type: research

Antibiotic use among hospitalized children under-five with lower respiratory tract infections: a multicenter, retrospective study from Punjab, Pakistan
Conclusions: Current surveillance study revealed a worrying degree of antibiotic misuse among hospitalized LRTI children aged ≤ 5 years.PMID:34047247 | DOI:10.1080/14787210.2021.1935235 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Zia Ul Mustafa Muhammad Salman Naeem Aslam Noman Asif Khalid Hussain Naureen Tanveer Khezar Hayat Source Type: research

IL28B, TLR7 SNPs, and cytomegalovirus infection are risk factors for advanced liver disease in chronic hepatitis C patients
CONCLUSION: IL28B, TLR7 SNPs and cytomegalovirus infection are risk factors for advanced liver disease in hepatitis C patients.PMID:34047252 | DOI:10.1080/14787210.2021.1935239 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - May 28, 2021 Category: Infectious Diseases Authors: Fatma Omar Khalil Ayman Alsebaey Zeinab Abdelaziz Kasemy Sabry Moawad Abdelmageed Hanan Mosaad Bedair Shimaa Abdelsattar Source Type: research

The rationale for including osteopathic manipulative treatment in the management of infections: A hermeneutic Review
Expert Rev Anti Infect Ther. 2021 May 25. doi: 10.1080/14787210.2021.1935236. Online ahead of print.ABSTRACTINTRODUCTION: : As the prevalence of drug-resistant infections continues to outpace the development of new antibiotics, we must explore all reasonable options for enhancing the effectiveness of existing anti-infectives. The emergence of novel pathogens without initial drug treatments or vaccines, typified by the severe acute respiratory syndrome coronavirus-2 pandemic, further underscores the need for non-pharmacologic adjunctive measures for infection management. Osteopathic manipulative treatment (OMT) may represen...
Source: Expert Review of Anti-Infective Therapy - May 26, 2021 Category: Infectious Diseases Authors: Emil Lesho Allison McKeown Maryrose Laguio-Vila Source Type: research

Progress on the national action plan of Pakistan on antimicrobial resistance (AMR): a scoping review and the implications
Expert Rev Anti Infect Ther. 2021 May 26. doi: 10.1080/14787210.2021.1935238. Online ahead of print.ABSTRACTINTRODUCTION: The emergence and spread of antimicrobial resistance (AMR) is a threat to public health. In 2015, the World Health Organization (WHO) introduced a global action plan to tackle AMR in World Health Assembly. Pakistan's national action plan (NAP) for AMR was released in May 2017 by the Ministry of National Health Services. Based on the NAP, strategies have been initiated on a national and provincial scale in Pakistan. A narrative review of the five components of the Pakistan NAP has been undertaken based o...
Source: Expert Review of Anti-Infective Therapy - May 26, 2021 Category: Infectious Diseases Authors: Zikria Saleem Brian Godman Faiza Azhar Aubrey C Kalungia Joseph Fadare Sylvia Opanga Vanda Markovic-Pekovic Iris Hoxha Amna Saeed Manal Al-Gethamy Abdul Haseeb Muhammad Salman Ayaz Ali Khan Muhammad Umer Nadeem Inaam Ur Rehman Muhammad Usman Qamar Afreeni Source Type: research

The rationale for including osteopathic manipulative treatment in the management of infections: A hermeneutic Review
Expert Rev Anti Infect Ther. 2021 May 25. doi: 10.1080/14787210.2021.1935236. Online ahead of print.ABSTRACTINTRODUCTION: : As the prevalence of drug-resistant infections continues to outpace the development of new antibiotics, we must explore all reasonable options for enhancing the effectiveness of existing anti-infectives. The emergence of novel pathogens without initial drug treatments or vaccines, typified by the severe acute respiratory syndrome coronavirus-2 pandemic, further underscores the need for non-pharmacologic adjunctive measures for infection management. Osteopathic manipulative treatment (OMT) may represen...
Source: Expert Review of Anti-Infective Therapy - May 26, 2021 Category: Infectious Diseases Authors: Emil Lesho Allison McKeown Maryrose Laguio-Vila Source Type: research

Progress on the national action plan of Pakistan on antimicrobial resistance (AMR): a scoping review and the implications
Expert Rev Anti Infect Ther. 2021 May 26. doi: 10.1080/14787210.2021.1935238. Online ahead of print.ABSTRACTINTRODUCTION: The emergence and spread of antimicrobial resistance (AMR) is a threat to public health. In 2015, the World Health Organization (WHO) introduced a global action plan to tackle AMR in World Health Assembly. Pakistan's national action plan (NAP) for AMR was released in May 2017 by the Ministry of National Health Services. Based on the NAP, strategies have been initiated on a national and provincial scale in Pakistan. A narrative review of the five components of the Pakistan NAP has been undertaken based o...
Source: Expert Review of Anti-Infective Therapy - May 26, 2021 Category: Infectious Diseases Authors: Zikria Saleem Brian Godman Faiza Azhar Aubrey C Kalungia Joseph Fadare Sylvia Opanga Vanda Markovic-Pekovic Iris Hoxha Amna Saeed Manal Al-Gethamy Abdul Haseeb Muhammad Salman Ayaz Ali Khan Muhammad Umer Nadeem Inaam Ur Rehman Muhammad Usman Qamar Afreeni Source Type: research

The rationale for including osteopathic manipulative treatment in the management of infections: A hermeneutic Review
Expert Rev Anti Infect Ther. 2021 May 25. doi: 10.1080/14787210.2021.1935236. Online ahead of print.ABSTRACTINTRODUCTION: : As the prevalence of drug-resistant infections continues to outpace the development of new antibiotics, we must explore all reasonable options for enhancing the effectiveness of existing anti-infectives. The emergence of novel pathogens without initial drug treatments or vaccines, typified by the severe acute respiratory syndrome coronavirus-2 pandemic, further underscores the need for non-pharmacologic adjunctive measures for infection management. Osteopathic manipulative treatment (OMT) may represen...
Source: Expert Review of Anti-Infective Therapy - May 26, 2021 Category: Infectious Diseases Authors: Emil Lesho Allison McKeown Maryrose Laguio-Vila Source Type: research

Progress on the national action plan of Pakistan on antimicrobial resistance (AMR): a scoping review and the implications
Expert Rev Anti Infect Ther. 2021 May 26. doi: 10.1080/14787210.2021.1935238. Online ahead of print.ABSTRACTINTRODUCTION: The emergence and spread of antimicrobial resistance (AMR) is a threat to public health. In 2015, the World Health Organization (WHO) introduced a global action plan to tackle AMR in World Health Assembly. Pakistan's national action plan (NAP) for AMR was released in May 2017 by the Ministry of National Health Services. Based on the NAP, strategies have been initiated on a national and provincial scale in Pakistan. A narrative review of the five components of the Pakistan NAP has been undertaken based o...
Source: Expert Review of Anti-Infective Therapy - May 26, 2021 Category: Infectious Diseases Authors: Zikria Saleem Brian Godman Faiza Azhar Aubrey C Kalungia Joseph Fadare Sylvia Opanga Vanda Markovic-Pekovic Iris Hoxha Amna Saeed Manal Al-Gethamy Abdul Haseeb Muhammad Salman Ayaz Ali Khan Muhammad Umer Nadeem Inaam Ur Rehman Muhammad Usman Qamar Afreeni Source Type: research

The association between neutrophil to lymphocyte ratio and endothelial dysfunction in people living with HIV on stable antiretroviral therapy
Expert Rev Anti Infect Ther. 2021 May 25. doi: 10.1080/14787210.2021.1933438. Online ahead of print.ABSTRACTBACKGROUND: Residual inflammation is thought to promote endothelial dysfunction and atherosclerotic cardiovascular disease risk among people living with HIV (PLWH) receiving antiretroviral therapy (ART). Whether the neutrophil to lymphocyte ratio (NLR), a putative marker of systemic inflammation, may be associated with endothelial dysfunction has not been investigated in PLWH on stable ART.RESEARCH DESIGN AND METHODS: In this cross-sectional study, 210 PLWH (mean age 49 years, 79% males, 88/7/5% Caucasians/Africans/H...
Source: Expert Review of Anti-Infective Therapy - May 25, 2021 Category: Infectious Diseases Authors: Vanessa Bianconi Elisabetta Schiaroli Massimo R Mannarino Amirhossein Sahebkar Francesco Paciosi Sara Benedetti Ettore Marini Matteo Pirro Daniela Francisci Source Type: research

Intravenous fosfomycin for the treatment of patients with bone and joint infections: a review
Expert Rev Anti Infect Ther. 2021 May 25. doi: 10.1080/14787210.2021.1932463. Online ahead of print.ABSTRACTINTRODUCTION: Fosfomycin is a wide spectrum bactericidal antibiotic with a unique mode of action, low toxicity and good penetration in tissues with deep seated infections, including bone and joint infections.AREAS COVERED: Data were extracted from 19 published articles. 365 patients, with broad age range, received intravenous fosfomycin for the treatment of bone and joint infections (including arthritis, acute and chronic osteomyelitis, discitis, periprosthetic joint infection). Fosfomycin was given as part of a comb...
Source: Expert Review of Anti-Infective Therapy - May 25, 2021 Category: Infectious Diseases Authors: Katerina G Tsegka Georgios L Voulgaris Margarita Kyriakidou Anastasios Kapaskelis Matthew E Falagas Source Type: research