Understanding mechanisms of virulence in MRSA: implications for anti-virulence treatment strategies
Expert Rev Anti Infect Ther. 2023 Jul 27. doi: 10.1080/14787210.2023.2242585. Online ahead of print.ABSTRACTINTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) is a widespread pathogen, often causing recurrent and deadly infections in the hospital and community. Many S. aureus virulence factors have been suggested as potential targets for antivirulence therapy to decrease the threat of diminishing antibiotic availability. Antivirulence methods hold promise due to their adjunctive and prophylactic potential and decreased risk for selective pressure.AREAS COVERED: This review describes the dominant virulence mec...
Source: Expert Review of Anti-Infective Therapy - July 28, 2023 Category: Infectious Diseases Authors: Roger C Hsieh Ryan Liu Dylan J Burgin Michael Otto Source Type: research

Invasive < em > Candida < /em > infection: epidemiology, clinical and therapeutic aspects of an evolving disease and the role of rezafungin
Expert Rev Anti Infect Ther. 2023 Jul 26. doi: 10.1080/14787210.2023.2240956. Online ahead of print.ABSTRACTINTRODUCTION: Invasive Candida Infections (ICIs) have undergone a series of significant epidemiological, pathophysiological, and clinical changes during the last decades, with a shift toward non-albicans species, an increase in the rate of exogenous infections and clinical manifestations ranging from candidemia to an array of highly invasive and life-threatening clinical syndromes. The long-acting echinocandin rezafungin exhibits potent in-vitro activity against most wild-type and azole-resistant Candida spp. includi...
Source: Expert Review of Anti-Infective Therapy - July 26, 2023 Category: Infectious Diseases Authors: Alessandra Oliva Francesco Giuseppe De Rosa Malgorzata Mikulska Federico Pea Maurizio Sanguinetti Carlo Tascini Mario Venditti Source Type: research

Identification of active compounds of traditional chinese medicine derived from maxing shigan decoction for COVID-19 treatment: a meta-analysis and in silico study
CONCLUSION: This study demonstrates the important role of MXSGD-related TCM in the treatment of COVID-19.PMID:37481738 | DOI:10.1080/14787210.2023.2238899 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - July 23, 2023 Category: Infectious Diseases Authors: Xiaodan Guo Yihua Lin Fengming He Ying Jin Simian Chen Ting Li Caisheng Wu Lin Zhang Xueqin Chen Source Type: research

Identification of active compounds of traditional chinese medicine derived from maxing shigan decoction for COVID-19 treatment: a meta-analysis and in silico study
CONCLUSION: This study demonstrates the important role of MXSGD-related TCM in the treatment of COVID-19.PMID:37481738 | DOI:10.1080/14787210.2023.2238899 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - July 23, 2023 Category: Infectious Diseases Authors: Xiaodan Guo Yihua Lin Fengming He Ying Jin Simian Chen Ting Li Caisheng Wu Lin Zhang Xueqin Chen Source Type: research

New advances in the treatments of drug-resistant tuberculosis
Expert Rev Anti Infect Ther. 2023 Jul 21. doi: 10.1080/14787210.2023.2240022. Online ahead of print.ABSTRACTINTRODUCTION: TB is associated with high mortality and morbidity among infected individuals and a high transmission rate from person to person. Despite the availability of vaccines and several anti-TB,TB infection continues to increase. Global resistance to TB remains the greatest challenge. There has not been extensive research into a new treatment and management strategy for TB resistance therapy. This review is based on a review of new advances and alternative drugs in the treatment of drug-resistant TB.AREAS COVE...
Source: Expert Review of Anti-Infective Therapy - July 21, 2023 Category: Infectious Diseases Authors: Mohanad Mahmoud Yurong Tan Source Type: research