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The clinical application of traditional Chinese medicine NRICM101 in hospitalized patients with COVID-19
CONCLUSION: NRICM101 did not reduce in-hospital mortality. However, it shortened the length of hospitalization and reduced mechanical ventilation days in initially severe cases. Further investigation is needed.PMID:38288986 | DOI:10.1080/14787210.2024.2313054 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - January 30, 2024 Category: Infectious Diseases Authors: Wen-Kuei Chang Chieh-Jen Wang Tung-Hu Tsai Fang-Ju Sun Chao-Hsien Chen Kuan-Chih Kuo Hsin-Pei Chung Yen-Hsiang Tang Yen-Ting Chen Kuo-Lun Wu Jou-Chun Wu Chang-Yi Lin Hai-Bo Zhang Source Type: research

Can adverse cardiac events of the COVID-19 vaccine exacerbate preexisting diseases?
Expert Rev Anti Infect Ther. 2024 Jan 29:1-7. doi: 10.1080/14787210.2024.2311837. Online ahead of print.ABSTRACTINTRODUCTION: SARS-CoV-2 infection and COVID-19 vaccination can both lead to serious cardiac conditions such as myocarditis, arrhythmia, acute myocardial infarction, and coagulopathy. Further studies are needed to better understand the risks and benefits of COVID-19 vaccination, and to determine the best course of action for individuals with preexisting heart conditions.AREAS COVERED: The current knowledge and challenges in understanding vaccine-associated heart issues concerning the COVID-19 pandemic are briefly...
Source: Expert Review of Anti-Infective Therapy - January 29, 2024 Category: Infectious Diseases Authors: Mohammed S Razzaque Source Type: research

Metallo-beta-lactamases: mechanisms, treatment challenges, and future prospects
We describe the mechanisms of action that differentiate MBLs from other beta-lactamases. We discuss the global epidemiology of MBL-producing organisms and their impact on patients' outcomes. By exposing the mechanisms of transmission of MBLs among bacterial populations, we emphasize the importance of infection prevention and control.EXPERT OPINION: MBLs are spreading globally and challenging the majority of available antibacterial agents. Genotypic tests play an important role in the identification of MBL production. Phenotypic tests are less specific but may be used in low-resource settings, where MBLs are more predominan...
Source: Expert Review of Anti-Infective Therapy - January 26, 2024 Category: Infectious Diseases Authors: Johnny Zakhour L'Emir Wassim El Ayoubi Souha S Kanj Source Type: research

Healthcare professionals' understanding and perception of drug-related issues linked to off-label pharmacological medications used for COVID-19
CONCLUSION: Most respondents had adequate knowledge. Older patients with comorbidities are at risk of adverse effects. Self-medication, polypharmacy, and multiple prescriptions can lead to misdiagnosis and complications. Electric prescriptions, team effort, and training programs can decrease these issues.PMID:38263904 | DOI:10.1080/14787210.2024.2310004 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - January 24, 2024 Category: Infectious Diseases Authors: Muhammad Zeeshan Munir Amer Hayat Khan Tahir Mehmood Khan Source Type: research

Ceftazidime-avibactam and aztreonam combination for Carbapenem-resistant Enterobacterales bloodstream infections with presumed Metallo- β-lactamase production: a systematic review and meta-analysis
CONCLUSION: The meta-analysis from studies with a high risk of bias shows that AA is associated with lesser 30-day mortality when compared to polymyxins in patients with MBL-producing CRE BSI. Registration with PROSPERO- CRD42023433608.PMID:38258529 | DOI:10.1080/14787210.2024.2307912 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - January 23, 2024 Category: Infectious Diseases Authors: Nitin Gupta Carl Boodman Parikshit Prayag Abi Manesh Tirlangi Praveen Kumar Source Type: research

Drug recommendation for optimization on treatment outcome for MDR/RR-TB based on a multi-center, large scale, retrospective cohort study in China
CONCLUSIONS: The recommendation order for the treatment of MDR/RR-TB is Bdq, Lzd, and Cs. FQs were decreased in use intensity. Injection drugs, whether Amk or Cm, are not recommended.PMID:38251634 | DOI:10.1080/14787210.2024.2303032 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - January 22, 2024 Category: Infectious Diseases Authors: Lin Fan Ming Yang Yu-Tong Han Fei Ren Hua Wang Jin-Bao Ma Guo-Hui Zhu Yan-Jun Xiong Xin-Xin Fan Su-Xia Chen Hao-Yu Wu Wen-Wen Sun Shao-Jun Zhang Hui Ke Xiao-Hong Cheng Biao Xu Yu Chen Chang Chen Source Type: research

Carbapenem-resistant Klebsiella pneumoniae : the role of plasmids in emergence, dissemination, and evolution of a major clinical challenge
Expert Rev Anti Infect Ther. 2024 Jan-Jun;22(1-3):25-43. doi: 10.1080/14787210.2024.2305854. Epub 2024 Feb 12.ABSTRACTINTRODUCTION: Klebsiella pneumoniae is a major agent of healthcare-associated infections and a cause of some community-acquired infections, including severe bacteremic infections associated with metastatic abscesses in liver and other organs. Clinical relevance is compounded by its outstanding propensity to evolve antibiotic resistance. In particular, the emergence and dissemination of carbapenem resistance in K. pneumoniae has posed a major challenge due to the few residual treatment options, which have on...
Source: Expert Review of Anti-Infective Therapy - January 18, 2024 Category: Infectious Diseases Authors: Vincenzo Di Pilato Simona Pollini Vivi Miriagou Gian Maria Rossolini Marco Maria D'Andrea Source Type: research

Could Herpesviridae be the cause of severe acute hepatitis of unknown origin in children?
Expert Rev Anti Infect Ther. 2024 Jan-Jun;22(1-3):5-17. doi: 10.1080/14787210.2024.2304637. Epub 2024 Feb 12.ABSTRACTINTRODUCTION: Severe acute hepatitis (SAH) is defined by a severe inflammation of hepatocytes in the liver parenchyma which can lead to an acute liver failure, a clinical condition with high mortality rate that can be triggered by several factors but is usually associated to hepatotropic viruses' infection. In 2022, cases of children with severe acute hepatitis of unknown origin hospitalized in Glasgow, Scotland, were reported. Possible causes of this condition include, but are not limited to, undiagnosed vi...
Source: Expert Review of Anti-Infective Therapy - January 15, 2024 Category: Infectious Diseases Authors: Livia Melo Villar Lucas Lima da Silva Barbara Vieira do Lago Jessica Gon çalves Pereira Ana Carolina Silva Guimar ães Francisco Campello do Amaral Mello Vanessa Salete de Paula Source Type: research

Phage therapy: resurrecting a historical solution for the contemporary challenge of rising antibiotic resistance in Latin America
Expert Rev Anti Infect Ther. 2024 Jan-Jun;22(1-3):19-23. doi: 10.1080/14787210.2024.2305842. Epub 2024 Feb 12.ABSTRACTINTRODUCTION: Antimicrobial resistance in Latin America is a growing concern in both human and non-human animal populations. The economic burden that is likely to be imposed through increased resistance will cause further strains on public health systems and the population at large.AREAS COVERED: We propose the rapid adoption and implementation of phage therapy as a necessary addition to the medical arsenal to help mitigate antimicrobial resistance, with an emphasis on considering the potential benefits tha...
Source: Expert Review of Anti-Infective Therapy - January 13, 2024 Category: Infectious Diseases Authors: Justin Yeager Ana Mar ía Gómez-Jaramillo Esteban Ortiz-Prado Manuel Calvopi ña Benjamin K Chan Source Type: research

Waking up to the Naegleria threat: urgent measures needed to protect public health in Pakistan
Expert Rev Anti Infect Ther. 2024 Jan 9:1-2. doi: 10.1080/14787210.2024.2304055. Online ahead of print.NO ABSTRACTPMID:38193480 | DOI:10.1080/14787210.2024.2304055 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - January 9, 2024 Category: Infectious Diseases Authors: Ifrah Ata Nabeel Riaz Fariah Ata Umer Farooq Tauqeer Hussain Mallhi Source Type: research

Waking up to the Naegleria threat: urgent measures needed to protect public health in Pakistan
Expert Rev Anti Infect Ther. 2024 Jan 9. doi: 10.1080/14787210.2024.2304055. Online ahead of print.NO ABSTRACTPMID:38193480 | DOI:10.1080/14787210.2024.2304055 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - January 9, 2024 Category: Infectious Diseases Authors: Ifrah Ata Nabeel Riaz Fariah Ata Umer Farooq Tauqeer Hussain Mallhi Source Type: research

Predictors and patterns of empirical antibiotic therapy and associated outcomes in COVID-19 patients: a retrospective study in a tertiary care facility in South India
CONCLUSION: The study identified predictors for initiating empirical antibacterial therapy in our setting and highlighted the need for rational antibiotic therapy.PMID:38189087 | DOI:10.1080/14787210.2024.2303019 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - January 8, 2024 Category: Infectious Diseases Authors: Lipin Lukose Gursimran Kaur Mohammed Asif M Gail Ann Abraham Kanav Khera Subeesh K Viswam Ronald L Castelino Shubhada Karanth Chandrashekar Udyavara Kudru Muralidhar Varma Sonal Sekhar Miraj Source Type: research

Reviewing novel treatment options for carbapenem-resistant enterobacterales 
This article discusses previously published research supporting currently available novel antimicrobials for the treatment of CRE infections. Newer compounds currently being evaluated in clinical trials are covered. A literature search was conducted in PubMed over all available dates for relevant published papers and conference abstracts with the search terms, 'CRE,' 'carbapenem-resistant Enterobacterales,' 'β-lactam-β-lactamase inhibitor,' 'KPC,' 'NDM,' 'metallo-β-lactamase,' 'ceftazidime-avibactam,' 'meropenem-vaborbactam,' 'imipenem-cilastatin-relebactam,' 'cefiderocol,' 'eravacycline,' 'plazomicin,' 'taniborbactam,'...
Source: Expert Review of Anti-Infective Therapy - January 6, 2024 Category: Infectious Diseases Authors: Natalie A Mackow David van Duin Source Type: research