Impact of a multidisciplinary antimicrobial stewardship program on antibiotic utilization and clinical outcomes at a tertiary hospital in Saudi Arabia: a quasi-experimental study
CONCLUSION: The implemented multidisciplinary ASP intervention was associated with a significant improvement in antibiotic utilization and patient clinical outcomes.PMID:37974376 | DOI:10.1080/14787210.2023.2285425 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - November 17, 2023 Category: Infectious Diseases Authors: Khadijah A Sarkhi Khalid Eljaaly Reham Kaki Rahaf Bahamdan Sultan A Alghamdi Mohammed O Baharith Abrar K Thabit Source Type: research

Selling antibiotics without prescriptions among community pharmacies and drug outlets: a simulated client study from Ghana
CONCLUSIONS: A very high prevalence/sub-optimal practice of selling antibiotics without prescriptions was found. This highlights the need to increase compliance with antibiotic dispensing legislation through evidence-based interventions including education of key stakeholders.PMID:37975725 | DOI:10.1080/14787210.2023.2283037 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - November 17, 2023 Category: Infectious Diseases Authors: Eric Kofi Ngyedu Joseph Acolatse George Akafity Robert Incoom Audu Rauf R Andrew Seaton Jacqueline Sneddon Elaine Cameron Margaret Watson Marta Wanat Brian Godman Amanj Kurdi Source Type: research

The gut and lung microbiota in pulmonary tuberculosis: susceptibility, function, and new insights into treatment
Expert Rev Anti Infect Ther. 2023 Nov 16. doi: 10.1080/14787210.2023.2283036. Online ahead of print.ABSTRACTINTRODUCTION: Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) that poses a major threat to human health.AREAS COVERED: Herein, we aim to review the alteration of the microbiota in gut and respiratory during TB development, the potential function and mechanisms of microbiota in the pathogenesis of Mtb infection, and the impact of antibiotic treatment on the microbiota. In addition, we discuss the potential new paradigm for the use of microbiota-based treatments such as prob...
Source: Expert Review of Anti-Infective Therapy - November 16, 2023 Category: Infectious Diseases Authors: Qiqi Zhuo Xianyi Zhang Kehong Zhang Chan Chen Zhen Huang Yuzhong Xu Source Type: research

Clinical efficacy of nirmatrelvir plus ritonavir in patients with COVID-19 and preexisting cardiovascular diseases
CONCLUSIONS: Our findings indicate that NMV-r to treat COVID-19 could reduce all-cause hospitalization and death in patients with CVDs.PMID:37965890 | DOI:10.1080/14787210.2023.2284367 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - November 15, 2023 Category: Infectious Diseases Authors: Ting-Hui Liu Jheng-Yan Wu Po-Yu Huang Wan-Hsuan Hsu Min-Hsiang Chuang Ya-Wen Tsai Chih-Cheng Lai Chun-Yen Huang Source Type: research

Practical diagnostic algorithms for Chagas disease: a focus on low resource settings
Expert Rev Anti Infect Ther. 2023 Nov 7. doi: 10.1080/14787210.2023.2279110. Online ahead of print.ABSTRACTINTRODUCTION: Chagas disease, caused by parasite Trypanosoma cruzi, is the most important neglected tropical disease in the Americas. Two drugs are available for treatment, but access to them is challenging, in part due to complex diagnostic algorithms. These are stage-dependent, involve multiple tests and are ill-adapted to the reality of vast areas where the disease is endemic. Molecular and serologic tools are used to detect acute and chronic infections, with the performance of the latter showing geographic differe...
Source: Expert Review of Anti-Infective Therapy - November 7, 2023 Category: Infectious Diseases Authors: Juan Carlos Gabald ón-Figueira Malia Skjefte Silvia Longhi Elisa Escabia Lady Juliette Garc ía Albert Ros-Lucas Nieves Mart ínez-Peinado Arturo Mu ñoz-Calderón Joaquim Gasc ón Alejandro Gabriel Schijman Julio Alonso-Padilla Source Type: research

Advantages and limitations of current diagnostic laboratory approaches in syphilis and congenital syphilis
Expert Rev Anti Infect Ther. 2023 Nov 7. doi: 10.1080/14787210.2023.2280214. Online ahead of print.ABSTRACTINTRODUCTION: The reemergence of syphilis, especially congenital syphilis, presents a significant public health threat. Accurate diagnosis of syphilis depends on recognition of a constellation of symptoms, review of medical and sexual history, and multiple laboratory tests. While reliable, current tests for syphilis can be difficult to interpret, which can lead to delays in treatment.AREA COVERED: This review summarizes the major advantages and limitations of available diagnostic laboratory methods for syphilis, provi...
Source: Expert Review of Anti-Infective Therapy - November 7, 2023 Category: Infectious Diseases Authors: Weiping Cao Phoebe G Thorpe Kevin O'Callaghan Ellen N Kersh Source Type: research

Practical diagnostic algorithms for Chagas disease: a focus on low resource settings
Expert Rev Anti Infect Ther. 2023 Nov 7. doi: 10.1080/14787210.2023.2279110. Online ahead of print.ABSTRACTINTRODUCTION: Chagas disease, caused by parasite Trypanosoma cruzi, is the most important neglected tropical disease in the Americas. Two drugs are available for treatment, but access to them is challenging, in part due to complex diagnostic algorithms. These are stage-dependent, involve multiple tests and are ill-adapted to the reality of vast areas where the disease is endemic. Molecular and serologic tools are used to detect acute and chronic infections, with the performance of the latter showing geographic differe...
Source: Expert Review of Anti-Infective Therapy - November 7, 2023 Category: Infectious Diseases Authors: Juan Carlos Gabald ón-Figueira Malia Skjefte Silvia Longhi Elisa Escabia Lady Juliette Garc ía Albert Ros-Lucas Nieves Mart ínez-Peinado Arturo Mu ñoz-Calderón Joaquim Gasc ón Alejandro Gabriel Schijman Julio Alonso-Padilla Source Type: research

Advantages and limitations of current diagnostic laboratory approaches in syphilis and congenital syphilis
Expert Rev Anti Infect Ther. 2023 Nov 7. doi: 10.1080/14787210.2023.2280214. Online ahead of print.ABSTRACTINTRODUCTION: The reemergence of syphilis, especially congenital syphilis, presents a significant public health threat. Accurate diagnosis of syphilis depends on recognition of a constellation of symptoms, review of medical and sexual history, and multiple laboratory tests. While reliable, current tests for syphilis can be difficult to interpret, which can lead to delays in treatment.AREA COVERED: This review summarizes the major advantages and limitations of available diagnostic laboratory methods for syphilis, provi...
Source: Expert Review of Anti-Infective Therapy - November 7, 2023 Category: Infectious Diseases Authors: Weiping Cao Phoebe G Thorpe Kevin O'Callaghan Ellen N Kersh Source Type: research

Practical diagnostic algorithms for Chagas disease: a focus on low resource settings
Expert Rev Anti Infect Ther. 2023 Nov 7. doi: 10.1080/14787210.2023.2279110. Online ahead of print.ABSTRACTINTRODUCTION: Chagas disease, caused by parasite Trypanosoma cruzi, is the most important neglected tropical disease in the Americas. Two drugs are available for treatment, but access to them is challenging, in part due to complex diagnostic algorithms. These are stage-dependent, involve multiple tests and are ill-adapted to the reality of vast areas where the disease is endemic. Molecular and serologic tools are used to detect acute and chronic infections, with the performance of the latter showing geographic differe...
Source: Expert Review of Anti-Infective Therapy - November 7, 2023 Category: Infectious Diseases Authors: Juan Carlos Gabald ón-Figueira Malia Skjefte Silvia Longhi Elisa Escabia Lady Juliette Garc ía Albert Ros-Lucas Nieves Mart ínez-Peinado Arturo Mu ñoz-Calderón Joaquim Gasc ón Alejandro Gabriel Schijman Julio Alonso-Padilla Source Type: research

Advantages and limitations of current diagnostic laboratory approaches in syphilis and congenital syphilis
Expert Rev Anti Infect Ther. 2023 Nov 7. doi: 10.1080/14787210.2023.2280214. Online ahead of print.ABSTRACTINTRODUCTION: The reemergence of syphilis, especially congenital syphilis, presents a significant public health threat. Accurate diagnosis of syphilis depends on recognition of a constellation of symptoms, review of medical and sexual history, and multiple laboratory tests. While reliable, current tests for syphilis can be difficult to interpret, which can lead to delays in treatment.AREA COVERED: This review summarizes the major advantages and limitations of available diagnostic laboratory methods for syphilis, provi...
Source: Expert Review of Anti-Infective Therapy - November 7, 2023 Category: Infectious Diseases Authors: Weiping Cao Phoebe G Thorpe Kevin O'Callaghan Ellen N Kersh Source Type: research

Practical diagnostic algorithms for Chagas disease: a focus on low resource settings
Expert Rev Anti Infect Ther. 2023 Nov 7. doi: 10.1080/14787210.2023.2279110. Online ahead of print.ABSTRACTINTRODUCTION: Chagas disease, caused by parasite Trypanosoma cruzi, is the most important neglected tropical disease in the Americas. Two drugs are available for treatment, but access to them is challenging, in part due to complex diagnostic algorithms. These are stage-dependent, involve multiple tests and are ill-adapted to the reality of vast areas where the disease is endemic. Molecular and serologic tools are used to detect acute and chronic infections, with the performance of the latter showing geographic differe...
Source: Expert Review of Anti-Infective Therapy - November 7, 2023 Category: Infectious Diseases Authors: Juan Carlos Gabald ón-Figueira Malia Skjefte Silvia Longhi Elisa Escabia Lady Juliette Garc ía Albert Ros-Lucas Nieves Mart ínez-Peinado Arturo Mu ñoz-Calderón Joaquim Gasc ón Alejandro Gabriel Schijman Julio Alonso-Padilla Source Type: research

Advantages and limitations of current diagnostic laboratory approaches in syphilis and congenital syphilis
Expert Rev Anti Infect Ther. 2023 Nov 7. doi: 10.1080/14787210.2023.2280214. Online ahead of print.ABSTRACTINTRODUCTION: The reemergence of syphilis, especially congenital syphilis, presents a significant public health threat. Accurate diagnosis of syphilis depends on recognition of a constellation of symptoms, review of medical and sexual history, and multiple laboratory tests. While reliable, current tests for syphilis can be difficult to interpret, which can lead to delays in treatment.AREA COVERED: This review summarizes the major advantages and limitations of available diagnostic laboratory methods for syphilis, provi...
Source: Expert Review of Anti-Infective Therapy - November 7, 2023 Category: Infectious Diseases Authors: Weiping Cao Phoebe G Thorpe Kevin O'Callaghan Ellen N Kersh Source Type: research

Practical diagnostic algorithms for Chagas disease: a focus on low resource settings
Expert Rev Anti Infect Ther. 2023 Nov 7. doi: 10.1080/14787210.2023.2279110. Online ahead of print.ABSTRACTINTRODUCTION: Chagas disease, caused by parasite Trypanosoma cruzi, is the most important neglected tropical disease in the Americas. Two drugs are available for treatment, but access to them is challenging, in part due to complex diagnostic algorithms. These are stage-dependent, involve multiple tests and are ill-adapted to the reality of vast areas where the disease is endemic. Molecular and serologic tools are used to detect acute and chronic infections, with the performance of the latter showing geographic differe...
Source: Expert Review of Anti-Infective Therapy - November 7, 2023 Category: Infectious Diseases Authors: Juan Carlos Gabald ón-Figueira Malia Skjefte Silvia Longhi Elisa Escabia Lady Juliette Garc ía Albert Ros-Lucas Nieves Mart ínez-Peinado Arturo Mu ñoz-Calderón Joaquim Gasc ón Alejandro Gabriel Schijman Julio Alonso-Padilla Source Type: research