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Host defense mechanisms against Candida auris 
Expert Rev Anti Infect Ther. 2023 Sep 27:1-10. doi: 10.1080/14787210.2023.2264500. Online ahead of print.ABSTRACTINTRODUCTION: Candida auris is a pathogen of growing public health concern given its rapid spread across the globe, its propensity for long-term skin colonization and healthcare-related outbreaks, its resistance to a variety of antifungal medications, and the high morbidity and mortality associated with invasive disease. Despite that, the host immune response mechanisms that operate during C. auris skin colonization and invasive infection remains poorly understood.AREAS COVERED: In this manuscript, we review the...
Source: Expert Review of Anti-Infective Therapy - September 27, 2023 Category: Infectious Diseases Authors: Joseph Pechacek Michail S Lionakis Source Type: research

Identification of antibiotic consumption targets for the management of Clostridioides difficile infection in hospitals- a threshold logistic modelling approach
CONCLUSION: Using threshold logistic analysis, critical incidence levels and antibiotic use targets to control HOHA CDI were determined. Threshold logistic models can be used to inform and enhance the effective design and implementation of antimicrobial stewardship programs.PMID:37755320 | DOI:10.1080/14787210.2023.2263642 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 27, 2023 Category: Infectious Diseases Authors: Mamoon A Aldeyab Stuart E Bond Ian Gould Jade Lee-Milner Joseph J Spencer-Jones Achyut Guleri Adel Sadeq Feras Jirjees William J Lattyak Source Type: research

Host defense mechanisms against Candida auris 
Expert Rev Anti Infect Ther. 2023 Sep 27. doi: 10.1080/14787210.2023.2264500. Online ahead of print.ABSTRACTINTRODUCTION: Candida auris is a pathogen of growing public health concern given its rapid spread across the globe, its propensity for long-term skin colonization and healthcare related outbreaks, its resistance to a variety of antifungal medications, and the high morbidity and mortality associated with invasive disease. Despite that, the host immune response mechanisms that operate during C. auris skin colonization and invasive infection remains poorly understood.AREAS COVERED: In this manuscript, we review the avai...
Source: Expert Review of Anti-Infective Therapy - September 27, 2023 Category: Infectious Diseases Authors: Joseph Pechacek Michail S Lionakis Source Type: research

Identification of antibiotic consumption targets for the management of clostridioides difficile infection in hospitals- a threshold logistic modeling approach
CONCLUSION: Using threshold logistic analysis, critical incidence levels and antibiotic use targets to control HOHA CDI were determined. Threshold logistic models can be used to inform and enhance the effective design and implementation of antimicrobial stewardship programs.PMID:37755320 | DOI:10.1080/14787210.2023.2263642 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 27, 2023 Category: Infectious Diseases Authors: Mamoon A Aldeyab Stuart E Bond Ian Gould Jade Lee-Milner Joseph J Spencer-Jones Achyut Guleri Adel Sadeq Feras Jirjees William J Lattyak Source Type: research

Fighting with brain-eating amoeba: challenges and new insights to open a road for the treatment of Naegleria fowleri infection
Expert Rev Anti Infect Ther. 2023 Sep 26:1-3. doi: 10.1080/14787210.2023.2263644. Online ahead of print.NO ABSTRACTPMID:37750324 | DOI:10.1080/14787210.2023.2263644 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 26, 2023 Category: Infectious Diseases Authors: Siva Nageswararao Gajula Lakshmi Vineela Nalla Source Type: research

How can we tackle the overuse of antibiotics in low- and middle-income countries?
Expert Rev Anti Infect Ther. 2023 Sep 25. doi: 10.1080/14787210.2023.2263643. Online ahead of print.ABSTRACTINTRODUCTION: Antibiotic overuse is a pressing global health concern, particularly in low- and middle-income countries (LMICs) where there is limited access to quality healthcare and insufficient regulation of antibiotic dispensation. This perspective piece highlights the challenges of antibiotic overuse in LMICs and provides insights into potential solutions to address this issue.AREAS COVERED: This perspective explores key factors contributing to antibiotic overuse in LMICs, encompassing weak healthcare infrastruct...
Source: Expert Review of Anti-Infective Therapy - September 25, 2023 Category: Infectious Diseases Authors: Giorgia Sulis Sena Sayood Sumanth Gandra Source Type: research