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Identification of antibiotic consumption targets for the management of < em > clostridioides difficile < /em > infection in hospitals- a threshold logistic modeling approach
CONCLUSION: Using threshold logistic analysis, critical incidence levels and antibiotic use targets to control HOHA CDI were determined. Threshold logistic models can be used to inform and enhance the effective design and implementation of antimicrobial stewardship programs.PMID:37755320 | DOI:10.1080/14787210.2023.2263642 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 27, 2023 Category: Infectious Diseases Authors: Mamoon A Aldeyab Stuart E Bond Ian Gould Jade Lee-Milner Joseph J Spencer-Jones Achyut Guleri Adel Sadeq Feras Jirjees William J Lattyak Source Type: research

Host defense mechanisms against < em > Candida auris < /em >
Expert Rev Anti Infect Ther. 2023 Sep 27. doi: 10.1080/14787210.2023.2264500. Online ahead of print.ABSTRACTINTRODUCTION: Candida auris is a pathogen of growing public health concern given its rapid spread across the globe, its propensity for long-term skin colonization and healthcare related outbreaks, its resistance to a variety of antifungal medications, and the high morbidity and mortality associated with invasive disease. Despite that, the host immune response mechanisms that operate during C. auris skin colonization and invasive infection remains poorly understood.AREAS COVERED: In this manuscript, we review the avai...
Source: Expert Review of Anti-Infective Therapy - September 27, 2023 Category: Infectious Diseases Authors: Joseph Pechacek Michail S Lionakis Source Type: research

Fighting with brain-eating amoeba: challenges and new insights to open a road for the treatment of Naegleria fowleri infection
Expert Rev Anti Infect Ther. 2023 Sep 26:1-3. doi: 10.1080/14787210.2023.2263644. Online ahead of print.NO ABSTRACTPMID:37750324 | DOI:10.1080/14787210.2023.2263644 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 26, 2023 Category: Infectious Diseases Authors: Siva Nageswararao Gajula Lakshmi Vineela Nalla Source Type: research

How can we tackle the overuse of antibiotics in low- and middle-income countries?
Expert Rev Anti Infect Ther. 2023 Sep 25. doi: 10.1080/14787210.2023.2263643. Online ahead of print.ABSTRACTINTRODUCTION: Antibiotic overuse is a pressing global health concern, particularly in low- and middle-income countries (LMICs) where there is limited access to quality healthcare and insufficient regulation of antibiotic dispensation. This perspective piece highlights the challenges of antibiotic overuse in LMICs and provides insights into potential solutions to address this issue.AREAS COVERED: This perspective explores key factors contributing to antibiotic overuse in LMICs, encompassing weak healthcare infrastruct...
Source: Expert Review of Anti-Infective Therapy - September 25, 2023 Category: Infectious Diseases Authors: Giorgia Sulis Sena Sayood Sumanth Gandra Source Type: research

Current rates of purchasing of antibiotics without a prescription across sub-saharan Africa; rationale and potential programmes to reduce inappropriate dispensing and resistance
Expert Rev Anti Infect Ther. 2023 Sep 23. doi: 10.1080/14787210.2023.2259106. Online ahead of print.ABSTRACTINTRODUCTION: Antimicrobial resistance (AMR) is a global concern. Currently, the greatest mortality due to AMR is in Africa. A key driver continues to be high levels of dispensing of antibiotics without a prescription.AREAS COVERED: A need to document current rates of dispensing, their rationale and potential ways forward including antimicrobial stewardship programmes (ASPs). A narrative review was undertaken. The highest rates of antibiotic purchasing were in Eritrea (up to 89.2% of antibiotics dispensed), Ethiopia ...
Source: Expert Review of Anti-Infective Therapy - September 23, 2023 Category: Infectious Diseases Authors: Tiyani Milta Sono Eugene Yeika Aislinn Cook Aubrey Kalungia Sylvia A Opanga Joseph Elikem Efui Acolatse Israel Abebrese Sefah Ana Goli ć Jelić Stephen Campbell Giulia Lorenzetti Zia Ul Mustafa Vanda Markovi ć-Peković Amanj Kurdi Bene D Anand Paramadha Source Type: research

Langya henipavirus outbreak
Expert Rev Anti Infect Ther. 2023 Sep 19:1-4. doi: 10.1080/14787210.2023.2260561. Online ahead of print.NO ABSTRACTPMID:37724512 | DOI:10.1080/14787210.2023.2260561 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 19, 2023 Category: Infectious Diseases Authors: Vivek P Chavda Vasso Apostolopoulos Ranjit Sah Source Type: research

Computational analysis of target genes in monkeypox virus infection and potential therapeutic precursors
CONCLUSION: These results will be of high importance for the viral researchers to be tested in wet lab settings in designing potential inhibitors.PMID:37711024 | DOI:10.1080/14787210.2023.2259614 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 15, 2023 Category: Infectious Diseases Authors: Ashfaq Ahmad Aliya Orassay Sidra Majaz Aamir Saeed Darya Sadvokassova Alan Berdigaliyev Salar Ahmad Lian-Xiang Wang Yingqiu Xie Source Type: research

Concerns with current Drug Laws regarding the purchasing antibiotics without a prescription in Pakistan; ways forward to assist the national action plan
Expert Rev Anti Infect Ther. 2023 Sep 15:1-3. doi: 10.1080/14787210.2023.2260096. Online ahead of print.NO ABSTRACTPMID:37712181 | DOI:10.1080/14787210.2023.2260096 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - September 15, 2023 Category: Infectious Diseases Authors: Zikria Saleem Tiyani Milta Sono Brian Godman Source Type: research