The paths toward non-viral CAR-T cell manufacturing: A comprehensive review of state-of-the-art methods
This study aims to investigate the current state-of-the-art in non-viral methods of CAR-T cell manufacturing. In the first part of this study, after reviewing the advantages and disadvantages of the clinical use of viral vectors, different non-viral vectors and the path of their clinical translation are discussed. These vectors include transposons (sleeping beauty, piggyBac, Tol2, and Tc Buster), programmable nucleases (ZFNs, TALENs, and CRISPR/Cas9), mRNA, plasmids, minicircles, and nanoplasmids. Afterward, various methods for efficient delivery of non-viral vectors into the cells are reviewed.PMID:38702027 | DOI:10.1016/...
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yekta Metanat Patrik Viktor Ayesha Amajd Irwanjot Kaur Ashraf Mohammed Hamed Noor K Abed Al-Abadi Nathera Hussin Alwan M V N L Chaitanya Natrayan Lakshmaiya Pallavi Ghildiyal Othman Mahjoob Khalaf Carmen Iulia Ciongradi Ioan S ârbu Source Type: research
SMARCA4 alterations in non-small cell lung cancer: a systematic review and meta-analysis
CONCLUSION: Our findings suggest that SMARCA4 mutation negatively affects NSCLC OS and PFS. The prognostic effects of SMARCA4-co-occurring mutations and the predictive role of SMARCA4 mutation status in immunotherapy require further exploration.PMID:38702192 | DOI:10.1136/jcp-2024-209394 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Durgesh Wankhede Sandeep Grover Paul Hofman Source Type: research
The Missing Trial Variable: A Case Report on Dietary Modification in a Patient with Durable Complete Remission After an Immunotherapy Clinical Trial for Metastatic Bladder Cancer
Altern Ther Health Med. 2024 May 3:AT9333. Online ahead of print.ABSTRACTA patient with metastatic bladder cancer has had an ongoing 9-year complete remission on a clinical trial of immunotherapy with nivolumab and ipimumab, but he also was following an intensive dietary and nutritional supplement regimen. Whether this combination or the immunotherapy alone brought about his good outcome is unknown but could be clarified in future trials by improved data collection about dietary and supplement choices.PMID:38702166 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Linda L Isaacs Nicholas J Gonzalez Source Type: research
Male breast cancer differs from female breast cancer in molecular features that affect prognoses and drug responses
CONCLUSION: The poor prognosis of MBC compared to FBC is due to numerous molecular differences and resulting drug responses.PMID:38701649 | DOI:10.1016/j.tranon.2024.101980 (Source: Translational Oncology)
Source: Translational Oncology - May 3, 2024 Category: Cancer & Oncology Authors: Yangyang Li Yan Guo Fengzhi Chen Yuqing Cui Xuesong Chen Guangyue Shi Source Type: research
Contemporary Management of Pediatric Brainstem Tumors
Adv Tech Stand Neurosurg. 2024;49:231-254. doi: 10.1007/978-3-031-42398-7_11.ABSTRACTBrain tumors are the second most common malignancy in childhood. Around 15-20% of pediatric brain tumors occur in the brainstem. The most common type of brainstem tumor are diffuse tumors in the ventral pons, whereas focal tumors tend to arise from the midbrain, medulla, and dorsal pons. Glioma is the most common pathological entity. Contemporary management consists of surgery, radiotherapy, chemotherapy, and other adjuvant treatment. Surgical options range from biopsy to radical excision. Biopsy can be performed for diagnostic and prognos...
Source: Advances and Technical Standards in Neurosurgery - May 3, 2024 Category: Neurosurgery Authors: Sheng-Che Chou Yu-Ning Chen Hsin-Yi Huang Meng-Fai Kuo Tai-Tong Wong Sung-Hsin Kuo Shih-Hung Yang Source Type: research
Navigating the landscape of epitranscriptomics and host immunity
Genome Res. 2024 May 3. doi: 10.1101/gr.278412.123. Online ahead of print.ABSTRACTRNA modifications, also termed epitranscriptomic marks, encompass chemical alterations to individual nucleotides, including processes such as methylation and editing. These marks contribute to a wide range of biological processes, many of which are related to host immune system defense. The functions of immune-related RNA modifications can be categorized into three main groups: regulation of immunogenic RNAs, control of genes involved in innate immune response, and facilitation of adaptive immunity. Here, we provide an overview of recent rese...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Elaine Huang Clara Frydman Xinshu Xiao Source Type: research
Eosinophil-activating Semiconducting Polymer Nanoparticles for Cancer Photo-immunotherapy
Angew Chem Int Ed Engl. 2024 May 3:e202405358. doi: 10.1002/anie.202405358. Online ahead of print.ABSTRACTEosinophils are important immune effector cells that affect T cell-mediated antitumor immunity. However, the low frequency and restrained activity of eosinophils restricted the development of cancer immunotherapies. We herein report an eosinophil-activating semiconducting polymer nanoparticle (SPNe) to improve photodynamic tumor immunogenicity, modulate eosinophil chemotaxis, and reinvigorate T-cell immunity for activated cancer photo-immunotherapy. SPNe is composed of an amphiphilic semiconducting polymer and a dipept...
Source: Angewandte Chemie - May 3, 2024 Category: Chemistry Authors: Chi Zhang Jingsheng Huang Mengke Xu Jie Yu Wei Xin Shasha He Kanyi Pu Source Type: research
High-throughput molecular assays for inclusion in personalised oncology trials - State-of-the-art and beyond
J Intern Med. 2024 May 2. doi: 10.1111/joim.13785. Online ahead of print.ABSTRACTIn the last decades, the development of high-throughput molecular assays has revolutionised cancer diagnostics, paving the way for the concept of personalised cancer medicine. This progress has been driven by the introduction of such technologies through biomarker-driven oncology trials. In this review, strengths and limitations of various state-of-the-art sequencing technologies, including gene panel sequencing (DNA and RNA), whole-exome/whole-genome sequencing and whole-transcriptome sequencing, are explored, focusing on their ability to ide...
Source: Genomics Proteomics ... - May 3, 2024 Category: Genetics & Stem Cells Authors: Anders Edsj ö Hege G Russnes Janne Lehti ö David Tamborero Eivind Hovig Albrecht Stenzinger Richard Rosenquist PCM4EU consortium Source Type: research
A Prospective Observational Study of Autoimmune Encephalitis in Northwestern India
CONCLUSION: Autoimmune encephalitis (AIE), a potentially treatable immune-responsive entity, is a common neurological problem and may be an answer to a large number of cases having unexplained encephalitis. Good clinical acumen and knowledge are required for early diagnosis and treatment of this potentially reversible disorder. How to cite this article: Sharma B, Paul M, Bagaria AK. A Prospective Observational Study of Autoimmune Encephalitis in Northwestern India. J Assoc Physicians India 2023;71(9):39-44.PMID:38700300 | DOI:10.59556/japi.71.0312 (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Bhawna Sharma Madhuparna Paul Amit K Bagaria Source Type: research
PD-1/PD-L1 pathway: Current research in breast cancer
CONCLUSIONS: The combination of PD-1/PD-L1 is essential for many malignancies. According to the evidence presented, this combination presents both an opportunity and a challenge in cancer treatment. Since many solid cancers, especially BC, express high levels of PD-1/PD-L1, cancer treatment mainly involves targeted therapies.PMID:38701137 | DOI:10.3233/BD-249006 (Source: Breast Disease)
Source: Breast Disease - May 3, 2024 Category: Cancer & Oncology Authors: Salman Ardi Syamsu Muhammad Faruk Nilam Smaradania Elridho Sampepajung Agung Sindu Pranoto Febie Irsandy Iin Fadhilah Utami Tammasse Source Type: research
Efficacy and safety of transarterial chemoembolization combined with targeted therapy and immunotherapy versus with targeted monotherapy in unresectable hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: Current evidence suggests that, on the basis of TACE combined with targeted therapy, the addition of immunotherapy provides better clinical efficacy and survival benefits for unresectable HCC patients, with good tolerability.PMID:38701263 | DOI:10.1097/MD.0000000000038037 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Jingwen Feng Yi Zhao Lin Zhai Jingxu Zhou Source Type: research
Bone mineral density as an individual prognostic biomarker in NSCLC patients treated with immune checkpoint inhibitors
CONCLUSION: Lower baseline BMD is associated with worse clinical outcomes in NSCLC patients treated with ICIs. As a reliable and easily obtained individual prognostic biomarker, BMD can become a routine detection indicator before immunotherapy.PMID:38698843 | PMC:PMC11063287 | DOI:10.3389/fimmu.2024.1332303 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Jie Lou Bingxin Gong Yi Li Yusheng Guo Lin Li Jing Wang Weiwei Liu Ziang You Hongyong Zhang Feng Pan Bo Liang Lian Yang Guofeng Zhou Source Type: research
A Method for the Production of Recombinant VSVs with Confirmation of Biological Activity
Acta Naturae. 2024 Jan-Mar;16(1):59-66. doi: 10.32607/actanaturae.27314.ABSTRACTThe design of new effective cancer treatment methods is a promising and important research field in translational medicine. Oncolytic viruses can induce immunogenic cell death by activating the body's immune system to recognize tumor cells. This work presents the results for optimizing the production of recombinant vesicular stomatitis viruses (rVSVs). To ensure the assembly of viral particles, we developed the HEK293TN-T7 cell line, which stably expresses DNA-dependent RNA polymerase 7 for viral genome transcription, and obtained helper plasmi...
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: V D Moroz N B Gasanov A D Egorov A S Malogolovkin M O Nagornykh E N Subcheva E S Kolosova A Yu Fizikova R A Ivanov A V Karabelsky Source Type: research
Designing combination therapies for cancer treatment: application of a mathematical framework combining CAR T-cell immunotherapy and targeted radionuclide therapy
DISCUSSION: Mathematical models are crucial tools for optimizing the delivery of cancer combination therapy regimens with application along the lines of achieving cure, maximizing survival or minimizing toxicity.PMID:38698840 | PMC:PMC11063284 | DOI:10.3389/fimmu.2024.1358478 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Vikram Adhikarla Dennis Awuah Enrico Caserta Megan Minnix Maxim Kuznetsov Amrita Krishnan Jefferey Y C Wong John E Shively Xiuli Wang Flavia Pichiorri Russell C Rockne Source Type: research
Contemporary Management of Pediatric Brainstem Tumors
Adv Tech Stand Neurosurg. 2024;49:231-254. doi: 10.1007/978-3-031-42398-7_11.ABSTRACTBrain tumors are the second most common malignancy in childhood. Around 15-20% of pediatric brain tumors occur in the brainstem. The most common type of brainstem tumor are diffuse tumors in the ventral pons, whereas focal tumors tend to arise from the midbrain, medulla, and dorsal pons. Glioma is the most common pathological entity. Contemporary management consists of surgery, radiotherapy, chemotherapy, and other adjuvant treatment. Surgical options range from biopsy to radical excision. Biopsy can be performed for diagnostic and prognos...
Source: Advances and Technical Standards in Neurosurgery - May 3, 2024 Category: Neurosurgery Authors: Sheng-Che Chou Yu-Ning Chen Hsin-Yi Huang Meng-Fai Kuo Tai-Tong Wong Sung-Hsin Kuo Shih-Hung Yang Source Type: research
