Increased tumor-infiltrating plasmacytoid dendritic cells express high levels of PD-L2 and affect CD8 < sup > + < /sup > T lymphocyte infiltration in human laryngeal squamous cell carcinoma
In this study, flow cytometric analyses were conducted to characterize the infiltration of dendritic cells and T lymphocytes, along with their respective subgroups in tumor tissues (TT), para-carcinoma tissues (PT), and peripheral blood (PB) from LSCC patients. Immunohistochemical staining for CD4 and CD8, as well as immunofluorescence staining for CD123, were performed on serial tissue sections to investigate the co-localization of TI-pDC and tumor-infiltrating T lymphocytes (TIL) within the tumor microenvironment (TME). Our results demonstrated significantly lower percentages of all three DC subsets in PB compared to TT ...
Source: Translational Oncology - April 28, 2024 Category: Cancer & Oncology Authors: Yangyang Ji Yu Heng Xiaoke Zhu Duo Zhang Di Tang Jian Zhou Hanqing Lin Jingyu Ma Xuping Ding Lei Tao Liming Lu Source Type: research
Effects of chronic stress on cancer development and the therapeutic prospects of adrenergic signaling regulation
Biomed Pharmacother. 2024 Apr 27;175:116609. doi: 10.1016/j.biopha.2024.116609. Online ahead of print.ABSTRACTLong-term chronic stress is an important factor in the poor prognosis of cancer patients. Chronic stress reduces the tissue infiltration of immune cells in the tumor microenvironment (TME) by continuously activating the adrenergic signaling, inhibits antitumor immune response and tumor cell apoptosis while also inducing epithelial-mesenchymal transition (EMT) and tumor angiogenesis, promoting tumor invasion and metastasis. This review first summarizes how adrenergic signaling activates intracellular signaling by bi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Hao Zhang Yuwei Yang Yan Cao Jingzhi Guan Source Type: research
Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression
Immunopharmacol Immunotoxicol. 2024 Apr 28:1-10. doi: 10.1080/08923973.2024.2347315. Online ahead of print.ABSTRACTUp-regulating programmed cell death ligand-1(PD-L1) expressed on tumor cells and tumor-infiltrating myeloid cells interacting with up-regulated programmed cell death-1 (PD-1) expressed on tumor-infiltrating lymphoid cells greatly hinder their tumor-inhibiting effect. It is necessary to explore the deep mechanism of this negative effect, so as to find the potential methods to improve the immunotherapy efficiency. Here, we found that the PD-1 expression in lung cancer-infiltrating type II innate lymphoid cells (...
Source: Immunopharmacology and Immunotoxicology - April 28, 2024 Category: Allergy & Immunology Authors: Chaoyun Yin Yani Pa Guangyu Li Qiang Chen Xizu Wang Xijun He Huangao Zhou Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
Pruriginous vesicular eruption associated with nivolumab immunotherapy: A case of dermatitis herpetiformis
Ann Dermatol Venereol. 2024 Apr 27;151(2):103269. doi: 10.1016/j.annder.2024.103269. Online ahead of print.NO ABSTRACTPMID:38678772 | DOI:10.1016/j.annder.2024.103269 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - April 28, 2024 Category: Dermatology Authors: M Housset A Fayad Kazour C Paugam Y Le Corre A Croue L Martin D Lechevalier C Berthin Source Type: research
Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1
Eur J Med Chem. 2024 Apr 25;271:116433. doi: 10.1016/j.ejmech.2024.116433. Online ahead of print.ABSTRACTPD-1/PD-L1 pathway blockade is a promising immunotherapy for the treatment of cancer. In this manuscript, a series of triaryl compounds containing ester chains were designed and synthesized based on the pharmacophore studies of the lead BMS-1. After several SAR iterations, 22 showed the best biochemical activity binding to hPD-L1 with an IC50 of 1.21 nM in HTRF assay, and a KD value of 5.068 nM in SPR analysis. Cell-based experiments showed that 22 effectively promoted A549 cell death by restoring T-cell immune function...
Source: European Journal of Medicinal Chemistry - April 28, 2024 Category: Chemistry Authors: Yonglei Zhang Fucheng Yin Zhongwen Luo Shang Li Xinxin Li Siyuan Wan Yifan Chen Lingyi Kong Xiaobing Wang Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
Mechanistic role of pyroptosis in tumor microenvironment and tumor immunotherapy
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):260-267. doi: 10.14715/cmb/2024.70.4.41.ABSTRACTIn recent decades, extraordinary attention has been devoted to cell death pathways principally because of multifaceted regulatory roles in normal developmental and pathophysiological processes. The removal of functionally defective, infected or potentially malignant cells is regulated by programmed cell death (PCD) cascades. Pyroptotic cell death is a highly complicated pro-inflammatory form of cell death. Pyroptosis is characterized by the formation of pores in the plasma membrane by oligomerization of the N-terminal fragment...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Rukset Attar Muhammad Zahid Qureshi Uteuliyev Yerzhan Sabitaliyevich Ishmuratova Margarita Yulaevna Mirna Azalea Romero Source Type: research
MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients
In conclusion, the pan-cancer study indicates that MAL with excellent prognostic value is a potential immunotherapy target in multiple cancers.PMID:38678596 | DOI:10.14715/cmb/2024.70.4.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ruinian Zheng Biao Yao Yongkang Ye Ruijuan Luo Zhiming Wu Xiarong Hu Yinjiao Yuan Xuebing Pan Caixiang Liu Linxuan Huang Yongmei Luo Dan Yang NiYa Shang Yamin Tian Jun Jia Source Type: research
ASO Visual Abstract: Influence of Neoadjuvant Immunotherapy-Chemotherapy on Perioperative Outcomes in Locally Advanced Esophageal Adenocarcinoma
Ann Surg Oncol. 2024 Apr 28. doi: 10.1245/s10434-024-15338-1. Online ahead of print.NO ABSTRACTPMID:38679680 | DOI:10.1245/s10434-024-15338-1 (Source: Ann Oncol)
Source: Ann Oncol - April 28, 2024 Category: Cancer & Oncology Authors: Yehonatan Nevo James Tankel Henry Zao Jaime Ramirez Jonathan Cools-Lartigue Carmen Muller Thierry Alcindor Lorenzo Ferri Source Type: research
Effects of chronic stress on cancer development and the therapeutic prospects of adrenergic signaling regulation
Biomed Pharmacother. 2024 Apr 27;175:116609. doi: 10.1016/j.biopha.2024.116609. Online ahead of print.ABSTRACTLong-term chronic stress is an important factor in the poor prognosis of cancer patients. Chronic stress reduces the tissue infiltration of immune cells in the tumor microenvironment (TME) by continuously activating the adrenergic signaling, inhibits antitumor immune response and tumor cell apoptosis while also inducing epithelial-mesenchymal transition (EMT) and tumor angiogenesis, promoting tumor invasion and metastasis. This review first summarizes how adrenergic signaling activates intracellular signaling by bi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Hao Zhang Yuwei Yang Yan Cao Jingzhi Guan Source Type: research
Pruriginous vesicular eruption associated with nivolumab immunotherapy: A case of dermatitis herpetiformis
Ann Dermatol Venereol. 2024 Apr 27;151(2):103269. doi: 10.1016/j.annder.2024.103269. Online ahead of print.NO ABSTRACTPMID:38678772 | DOI:10.1016/j.annder.2024.103269 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - April 28, 2024 Category: Dermatology Authors: M Housset A Fayad Kazour C Paugam Y Le Corre A Croue L Martin D Lechevalier C Berthin Source Type: research
Research on the potential mechanism of Deapioplatycodin D against Pulmonary fibrosis based on bioinformatics and experimental verification
CONCLUSION: In short, these comprehensive analysis methods were employed to identify critical biomarkers closely related to PF, which helps to elucidate the pathogenesis and potential immunotherapy targets of PF. It also provides essential support for the potential of DPD against PF.PMID:38679121 | DOI:10.1016/j.ejphar.2024.176603 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Chao Li Aliya Abdurehim Shuang Zhao Qing Sun Jiawen Xu Junbo Xie Yanqing Zhang Source Type: research
Increased tumor-infiltrating plasmacytoid dendritic cells express high levels of PD-L2 and affect CD8 < sup > + < /sup > T lymphocyte infiltration in human laryngeal squamous cell carcinoma
In this study, flow cytometric analyses were conducted to characterize the infiltration of dendritic cells and T lymphocytes, along with their respective subgroups in tumor tissues (TT), para-carcinoma tissues (PT), and peripheral blood (PB) from LSCC patients. Immunohistochemical staining for CD4 and CD8, as well as immunofluorescence staining for CD123, were performed on serial tissue sections to investigate the co-localization of TI-pDC and tumor-infiltrating T lymphocytes (TIL) within the tumor microenvironment (TME). Our results demonstrated significantly lower percentages of all three DC subsets in PB compared to TT ...
Source: Translational Oncology - April 28, 2024 Category: Cancer & Oncology Authors: Yangyang Ji Yu Heng Xiaoke Zhu Duo Zhang Di Tang Jian Zhou Hanqing Lin Jingyu Ma Xuping Ding Lei Tao Liming Lu Source Type: research
Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression
Immunopharmacol Immunotoxicol. 2024 Apr 28:1-10. doi: 10.1080/08923973.2024.2347315. Online ahead of print.ABSTRACTUp-regulating programmed cell death ligand-1(PD-L1) expressed on tumor cells and tumor-infiltrating myeloid cells interacting with up-regulated programmed cell death-1 (PD-1) expressed on tumor-infiltrating lymphoid cells greatly hinder their tumor-inhibiting effect. It is necessary to explore the deep mechanism of this negative effect, so as to find the potential methods to improve the immunotherapy efficiency. Here, we found that the PD-1 expression in lung cancer-infiltrating type II innate lymphoid cells (...
Source: Immunopharmacology and Immunotoxicology - April 28, 2024 Category: Allergy & Immunology Authors: Chaoyun Yin Yani Pa Guangyu Li Qiang Chen Xizu Wang Xijun He Huangao Zhou Source Type: research
