Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer
World J Gastroenterol. 2024 Apr 28;30(16):2195-2208. doi: 10.3748/wjg.v30.i16.2195.ABSTRACTAs a highly invasive malignancy, esophageal cancer (EC) is a global health issue, and was the eighth most prevalent cancer and the sixth leading cause of cancer-related death worldwide in 2020. Due to its highly immunogenic nature, emer-ging immunotherapy approaches, such as immune checkpoint blockade, have demonstrated promising efficacy in treating EC; however, certain limitations and challenges still exist. In addition, tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment (TIME); ...
Source: World Journal of Gastroenterology : WJG - May 1, 2024 Category: Gastroenterology Authors: Xiao-Jun Zhang Yan Yu He-Ping Zhao Lei Guo Kun Dai Jing Lv Source Type: research
Mast Cell-Neutrophil Communication Regulates Allergic Diseases
Yakugaku Zasshi. 2024;144(5):483-488. doi: 10.1248/yakushi.23-00154-2.ABSTRACTAllergic diseases (e.g., food allergies) are a growing problem, with increasing numbers of individuals experiencing them worldwide. Congruently, the adverse reactions (e.g., anaphylaxis) associated with the administration of vaccines against emerging infectious diseases such as coronavirus disease 2019 (COVID-19) have become a familiar problem. Allergic diseases, which have a wide variety of symptoms, are difficult to prevent or cure; treatment is currently limited to therapeutic drugs or allergen immunotherapy. Therefore, elucidating new allergi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Ryo Suzuki Source Type: research
Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer
World J Gastroenterol. 2024 Apr 28;30(16):2195-2208. doi: 10.3748/wjg.v30.i16.2195.ABSTRACTAs a highly invasive malignancy, esophageal cancer (EC) is a global health issue, and was the eighth most prevalent cancer and the sixth leading cause of cancer-related death worldwide in 2020. Due to its highly immunogenic nature, emer-ging immunotherapy approaches, such as immune checkpoint blockade, have demonstrated promising efficacy in treating EC; however, certain limitations and challenges still exist. In addition, tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment (TIME); ...
Source: World Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Authors: Xiao-Jun Zhang Yan Yu He-Ping Zhao Lei Guo Kun Dai Jing Lv Source Type: research
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) - Lifileucel (Amtagvi)
Med Sci Monit. 2024 May 1;30:e944927. doi: 10.12659/MSM.944927.ABSTRACTOn February 16, 2024, the US Food and Drug Agency (FDA) granted accelerated approval to lifileucel (Amtagvi), an adoptive immune cell therapy with autologous ex vivo-expanded tumor-infiltrating lymphocytes (TILs) for adult patients with advanced or unresectable melanoma progressing after treatment with immune checkpoint inhibitors and, if BRAF V600 mutation-positive, BRAF/MEK inhibitors. The clinical studies supporting this regulatory approval have highlighted the complexity of the treatment manufacturing process and the requirements for patient selecti...
Source: Medical Science Monitor - May 1, 2024 Category: Research Authors: Dinah V Parums Source Type: research
Serum interleukin-10 and alpha-fetoprotein: A combined diagnostic approach for hepatocellular carcinoma in Egyptians with HCV
CONCLUSION: the reliability of AFP as a major HCC marker was poor. However, IL-10 levels are a novel biomarker for the degree of HCC inflammation, considering IL-10's potential role in HCV-HCC development. We suggest combining AFP with IL-10 to improve the diagnostic and prognostic value of HCC considerably. Future research on these biomarkers should prioritize their clinical validity, prognostic usefulness, and compatibility with other therapeutic approaches as immunotherapy.PMID:38692084 | DOI:10.1016/j.prp.2024.155327 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - May 1, 2024 Category: Pathology Authors: Mostafa A Sharafeldin Reda A Suef Adel A Mousa Dina H Ziadah Mohamed M S Farag Source Type: research
Microsatellite Instability, Mismatch Repair, and Tumor Mutation Burden in Lung Cancer
Surg Pathol Clin. 2024 Jun;17(2):295-305. doi: 10.1016/j.path.2023.11.011. Epub 2023 Dec 20.ABSTRACTSince US Food and Drug Administration approval of programmed death ligand 1 (PD-L1) as the first companion diagnostic for immune checkpoint inhibitors (ICIs) in non-small cell lung cancer, many patients have experienced increased overall survival. To improve selection of ICI responders versus nonresponders, microsatellite instability/mismatch repair deficiency (MSI/MMR) and tumor mutation burden (TMB) came into play. Clinical data show PD-L1, MSI/MMR, and TMB are independent predictive immunotherapy biomarkers. Harmonization...
Source: Clinical Lung Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Oana C Rosca Oana E Vele Source Type: research
Comparative effectiveness of immunotherapy and chemotherapy in patients with metastatic colorectal cancer stratified by microsatellite instability status
CONCLUSION: In this population-based study using the NCDB, immunotherapy treatment was associated with significantly improved OS compared to chemotherapy in patients with MSI-H metastatic colorectal cancer, but not in those with MSI-L/MSS metastatic colorectal cancer. Further studies are warranted to determine the optimal therapeutic approach for patients with MSI-L/MSS metastatic colorectal cancer.PMID:38689622 | PMC:PMC11056865 | DOI:10.5306/wjco.v15.i4.540 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Chen-Gu Niu Jing Zhang Aniket-Vijay Rao Utsav Joshi Patrick Okolo Source Type: research
Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy
Transl Oncol. 2024 Apr 30;45:101975. doi: 10.1016/j.tranon.2024.101975. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, mainly occurring in Asian countries with an increased incidence rate globally. Currently, several kinds of therapies have been deployed for HCC therapy including surgical resection, chemotherapy, radiotherapy and immunotherapy. However, this tumor is still incurable, requiring novel strategies for its treatment. The nanomedicine has provided the new insights regarding the treatment of cancer that liposomes as lipid-based nanoparticles, have been wid...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Seyedeh Setareh Samaei Mahshid Daryab Sarah Gholami Aryan Rezaee Navid Fatehi Romina Roshannia Saeed Hashemi Nazanin Javani Parham Rahmanian Reza Amani-Beni Mohammad Arad Zandieh Noushin Nabavi Mohsen Rashidi Neda Malgard Mehrdad Hashemi Afshin Taheriazam Source Type: research
Serum interleukin-10 and alpha-fetoprotein: A combined diagnostic approach for hepatocellular carcinoma in Egyptians with HCV
CONCLUSION: the reliability of AFP as a major HCC marker was poor. However, IL-10 levels are a novel biomarker for the degree of HCC inflammation, considering IL-10's potential role in HCV-HCC development. We suggest combining AFP with IL-10 to improve the diagnostic and prognostic value of HCC considerably. Future research on these biomarkers should prioritize their clinical validity, prognostic usefulness, and compatibility with other therapeutic approaches as immunotherapy.PMID:38692084 | DOI:10.1016/j.prp.2024.155327 (Source: Cancer Control)
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Mostafa A Sharafeldin Reda A Suef Adel A Mousa Dina H Ziadah Mohamed M S Farag Source Type: research
Formyl peptide enhances cancer immunotherapy by activating antitumoral neutrophils, and T cells
Biomed Pharmacother. 2024 Apr 30;175:116670. doi: 10.1016/j.biopha.2024.116670. Online ahead of print.ABSTRACTNeutrophils are heterogeneous and plastic, with the ability to polarize from antitumour to protumour phenotype and modulate tumour microenvironment components. While some advances have been made, the neutrophil-targeting therapy remains underexplored. Activation of formyl peptide receptors (FPRs) by formylated peptides is needed for local control of infection through the recruitment of activated neutrophils while the potential contribution of antitumour activity remains underexplored. Here, we demonstrate that neut...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Haixia Sun Shuxin Li Qiaoli Wang Chunxiang Luo Lanyi Zhong Guohui Wan Ziqian Li Gexin Zhao Xianzhang Bu Musheng Zeng Guokai Feng Source Type: research
Formyl peptide enhances cancer immunotherapy by activating antitumoral neutrophils, and T cells
Biomed Pharmacother. 2024 Apr 30;175:116670. doi: 10.1016/j.biopha.2024.116670. Online ahead of print.ABSTRACTNeutrophils are heterogeneous and plastic, with the ability to polarize from antitumour to protumour phenotype and modulate tumour microenvironment components. While some advances have been made, the neutrophil-targeting therapy remains underexplored. Activation of formyl peptide receptors (FPRs) by formylated peptides is needed for local control of infection through the recruitment of activated neutrophils while the potential contribution of antitumour activity remains underexplored. Here, we demonstrate that neut...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Haixia Sun Shuxin Li Qiaoli Wang Chunxiang Luo Lanyi Zhong Guohui Wan Ziqian Li Gexin Zhao Xianzhang Bu Musheng Zeng Guokai Feng Source Type: research
Unveiling the promise of PD1/PD-L1: A new dawn in immunotherapy for cholangiocarcinoma
This article seeks to meticulously review the latest studies on PD1/PD-L1 involvement in CCA, delving into their expression profiles, prognostic significance, contribution to oncogenic processes, and their potential clinical utility.PMID:38692063 | DOI:10.1016/j.biopha.2024.116659 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Fei Chen Jian Sheng Xiaoping Li Zhaofeng Gao Siqi Zhao Lingyu Hu Minjie Chen Jianguo Fei Zhengwei Song Source Type: research
Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy
Transl Oncol. 2024 Apr 30;45:101975. doi: 10.1016/j.tranon.2024.101975. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, mainly occurring in Asian countries with an increased incidence rate globally. Currently, several kinds of therapies have been deployed for HCC therapy including surgical resection, chemotherapy, radiotherapy and immunotherapy. However, this tumor is still incurable, requiring novel strategies for its treatment. The nanomedicine has provided the new insights regarding the treatment of cancer that liposomes as lipid-based nanoparticles, have been wid...
Source: Translational Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Seyedeh Setareh Samaei Mahshid Daryab Sarah Gholami Aryan Rezaee Navid Fatehi Romina Roshannia Saeed Hashemi Nazanin Javani Parham Rahmanian Reza Amani-Beni Mohammad Arad Zandieh Noushin Nabavi Mohsen Rashidi Neda Malgard Mehrdad Hashemi Afshin Taheriazam Source Type: research
Comprehensive quantifications of tumour microenvironment to predict the responsiveness to immunotherapy and prognosis for paediatric neuroblastomas
In this study, the TMEs of neuroblastoma were grouped by their genetic signatures into four distinct subtypes: immune enriched, immune desert, non-proliferative and fibrotic. An Immune Score and a Proliferation Score were constructed based on the molecular features of the subtypes to quantify the immune microenvironment or malignancy degree of cancer cells in neuroblastoma, respectively. The Immune Score correlated with a patient's response to immunotherapy; the Proliferation Score was an independent prognostic biomarker for neuroblastoma and proved to be more accurate than the existing clinical predictors. This double sco...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Mingkun Song Yiming Sun Yikai Hu Chong Wang Yan Jin Yun Liu Yurong Da Qiang Zhao Rongxiu Zheng Long Li Source Type: research
Neutrophils in pancreatic ductal adenocarcinoma: bridging preclinical insights to clinical prospects for improved therapeutic strategies
Expert Rev Clin Immunol. 2024 May 1. doi: 10.1080/1744666X.2024.2348605. Online ahead of print.ABSTRACTINTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a dismal five-year survival rate of less than 10%. Neutrophils are key components of the innate immune system, playing a pivotal role in the PDAC immune microenvironment.AREAS COVERED: This review provides a comprehensive survey of the pivotal involvement of neutrophils in the tumorigenesis and progression of PDAC. Furthermore, it synthesizes preclinical and clinical explorations aimed at targeting neutrophils within t...
Source: Expert Review of Clinical Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Yi Jin Eric S Christenson Lei Zheng Keyu Li Source Type: research
