Finding your CAR: The road ahead for engineered T-cells
Am J Pathol. 2024 Apr 30:S0002-9440(24)00162-7. doi: 10.1016/j.ajpath.2024.04.002. Online ahead of print.ABSTRACTAdoptive cellular therapy using chimeric antigen receptors (CAR) has transformed immunotherapy by engineering T cells to target specific antigens on tumor cells. As the field continues to advance, pathology laboratories will play increasingly essential roles in the complicated multi-step process of CAR-T therapy. These include the detection of targetable tumor antigens by flow cytometry or immunohistochemistry at the time of disease diagnosis and the isolation and infusion of CAR-T cells. Additional roles includ...
Source: Am J Pathol - May 2, 2024 Category: Pathology Authors: Po-Han Chen Rianna Raghunandan Jon S Morrow Samuel G Katz Source Type: research
Finding your CAR: The road ahead for engineered T-cells
Am J Pathol. 2024 Apr 30:S0002-9440(24)00162-7. doi: 10.1016/j.ajpath.2024.04.002. Online ahead of print.ABSTRACTAdoptive cellular therapy using chimeric antigen receptors (CAR) has transformed immunotherapy by engineering T cells to target specific antigens on tumor cells. As the field continues to advance, pathology laboratories will play increasingly essential roles in the complicated multi-step process of CAR-T therapy. These include the detection of targetable tumor antigens by flow cytometry or immunohistochemistry at the time of disease diagnosis and the isolation and infusion of CAR-T cells. Additional roles includ...
Source: The American Journal of Pathology - May 2, 2024 Category: Pathology Authors: Po-Han Chen Rianna Raghunandan Jon S Morrow Samuel G Katz Source Type: research
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4
Pharmacol Rev. 2024 May 2;76(3):388-413. doi: 10.1124/pharmrev.123.000901.ABSTRACTThe involvement of the prostaglandin E2 (PGE2) system in cancer progression has long been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with pleiotropic effects in the human body. High levels of intratumoral PGE2 and overexpression of the key metabolic enzymes of PGE2 have been observed and suggested to contribute to tumor progression. This has been claimed for different types of solid tumors, including, but not limited to, lung, breast, and colon cancer. PGE2 has direct effects on tumor cells and angiogenesis th...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Ana Santiso Akos Heinemann Julia Kargl Source Type: research
MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future
In conclusion, targeting MDM2 remains a promising treatment approach, and targeting MDM2 for protein degradation represents a novel strategy to downregulate MDM2 without the side effects of the existing agents blocking p53-MDM2 binding. Additional preclinical and clinical investigations are needed to finally realize the full potential of MDM2 inhibition in treating cancer and other chronic diseases where MDM2 has been implicated. SIGNIFICANCE STATEMENT: Overexpression/amplification of the MDM2 oncogene has been detected in various human cancers and is associated with disease progression, treatment resistance, and poor pati...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Wei Wang Najah Albadari Yi Du Josef F Fowler Hannah T Sang Wa Xian Frank McKeon Wei Li Jia Zhou Ruiwen Zhang Source Type: research
Application of Genomic Medicine in Africa: 14th Conference of the African Society of Human Genetics and the 2nd International Congress of the Moroccan Society of Genomics and Human Genetics, Rabat, Morocco 2022
Am J Trop Med Hyg. 2024 May 2:tpmd230808. doi: 10.4269/ajtmh.23-0808. Online ahead of print.ABSTRACTThe 14th African Society of Human Genetics (AfSHG) Morocco Meeting and 2nd International Congress of the Moroccan Society of Genomics and Human Genetics (SM2GH), held in Rabat, Morocco, from December 12 through 17, 2022, brought together 298 attendees from 23 countries, organized by the AfSHG in collaboration with the SM2GH. The conference's overarching theme was "Applications of Genomics Medicine in Africa," covering a wide range of topics, including population genetics, genetics of infectious diseases, hereditary disorders...
Source: Am J Trop Med Hyg - May 2, 2024 Category: Infectious Diseases Authors: Meryem Fakhkhari Ikram Salih Najwa Maazaz Victoria Nembaware Nchangwi Syntia Munung Alice Matimba Sanaa Chala Ahmed Belmouden Karon Chappell Leon Mutesa Ghada El-Kamah Hicham Oumzil Larbi Baassi Younes Abbas Mohamed Zahir Alimohamed Michele Ramsay Scott W Source Type: research
The Age Specific Microbiome of Children with Milk, Egg, and Peanut Allergy
CONCLUSION: Dysbiosis associates with food allergy, most prominent in peanut-allergic older children. Younger children with and without food allergy have fewer differences in gut microbiota. This correlates with clinical observations of persistence of peanut allergy, and improved efficacy and safety of oral immunotherapy in younger children. Age under 3 should be considered when initiating therapeutic interventions.PMID:38697287 | DOI:10.1016/j.anai.2024.04.028 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Punita Ponda Jane E Cerise Brianne Navetta-Modrov Jamie Kiehm Grace M Covelli Jared Weiss Annette T Lee Source Type: research
Application of Genomic Medicine in Africa: 14th Conference of the African Society of Human Genetics and the 2nd International Congress of the Moroccan Society of Genomics and Human Genetics, Rabat, Morocco 2022
Am J Trop Med Hyg. 2024 May 2:tpmd230808. doi: 10.4269/ajtmh.23-0808. Online ahead of print.ABSTRACTThe 14th African Society of Human Genetics (AfSHG) Morocco Meeting and 2nd International Congress of the Moroccan Society of Genomics and Human Genetics (SM2GH), held in Rabat, Morocco, from December 12 through 17, 2022, brought together 298 attendees from 23 countries, organized by the AfSHG in collaboration with the SM2GH. The conference's overarching theme was "Applications of Genomics Medicine in Africa," covering a wide range of topics, including population genetics, genetics of infectious diseases, hereditary disorders...
Source: The American Journal of Tropical Medicine and Hygiene - May 2, 2024 Category: Tropical Medicine Authors: Meryem Fakhkhari Ikram Salih Najwa Maazaz Victoria Nembaware Nchangwi Syntia Munung Alice Matimba Sanaa Chala Ahmed Belmouden Karon Chappell Leon Mutesa Ghada El-Kamah Hicham Oumzil Larbi Baassi Younes Abbas Mohamed Zahir Alimohamed Michele Ramsay Scott W Source Type: research
Cascade-Targeted Nanoplatforms for Synergetic Antibiotic/ROS/NO/Immunotherapy against Intracellular Bacterial Infection
Biomacromolecules. 2024 May 1. doi: 10.1021/acs.biomac.4c00339. Online ahead of print.ABSTRACTIntracellular bacteria in dormant states can escape the immune response and tolerate high-dose antibiotic treatment, leading to severe infections. To overcome this challenge, cascade-targeted nanoplatforms that can target macrophages and intracellular bacteria, exhibiting synergetic antibiotic/reactive oxygen species (ROS)/nitric oxide (NO)/immunotherapy, were developed. These nanoplatforms were fabricated by encapsulating trehalose (Tr) and vancomycin (Van) into phosphatidylserine (PS)-coated poly[(4-allylcarbamoylphenylboric aci...
Source: Biomacromolecules - May 2, 2024 Category: Biochemistry Authors: Xiaomei Dai Xiaojun Liu Xingxing Wang Yongjie Zhang Yu Li Feng Gao Source Type: research
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma
This study aimed to develop a prognostic signature of bilirubin metabolism-associated genes (BMAGs) to predict outcomes and efficacy of immunotherapy in LUAD. We analysed gene expression data from The Cancer Genome Atlas (TCGA) to identify survival-related BMAGs and construct a prognostic model in LUAD. The prognostic efficacy of our model was corroborated by employing TCGA-LUAD and five Gene Expression Omnibus datasets, effectively stratifying patients into risk-defined cohorts with marked disparities in survival. The BMAG signature was indeed an independent prognostic determinant, outperforming established clinical param...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Kangqi Ren Xiean Ling Lin Chen Zeyao Li Tonghai Huang Source Type: research
Extracellular Vesicles-powered Immunotherapy: Unleashing the Potential for Safer and More Effective Cancer Treatment
This article discusses the importance of integrating nanomedicines into OIMTs, highlighting the challenges with current anti-OIMT methods. It also explores key considerations for designing nanomedicines tailored for OIMTs, aiming to improve upon existing immunotherapy techniques. Additionally, the article looks into innovative approaches like biomimicry and the use of natural biomaterial-based nanocarriers (NCs). These advancements have the potential to transform the delivery of immunotherapy. Lastly, the article addresses the challenges of moving OIMTs from theory to clinical practice, providing insights into the future o...
Source: Archives of Biochemistry and Biophysics - May 2, 2024 Category: Biochemistry Authors: Pratiksha Tiwari Krishna Yadav Ravi Prakash Shukla Avijit Kumar Bakshi Dilip Panwar Sweety Das Prabhat Ranjan Mishra Source Type: research
Very unusual extremely high ferritin with cytokine release syndrome in a patient with hematological malignancy after experimental chimeric antigen receptor (CAR)-T-Cell therapy
CONCLUSIONS: Cytokine release syndrome after experimental (CAR) T cell therapy may cause extremely elevated ferritin and hemophagocytic lymphohistiocytosis -like syndrome.PMID:38697457 | DOI:10.1016/j.cca.2024.119704 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - May 2, 2024 Category: Chemistry Authors: Robert Hoyt Zhan Ye Amitava Dasgupta Source Type: research
Clinical outcomes associated with neoadjuvant therapy for the treatment of resectable non-small cell lung cancer in real-world practice
CONCLUSIONS: Neoadjuvant treatment with a combination of immunotherapy plus chemotherapy appears to achieve higher radiological and pathological responses than monotherapy for IIA-IIIB NSCLC. Log-rank analysis showed that a better outcome could be expected in patients with the addition of immunotherapy to neoadjuvant chemotherapy if compared with patients with chemotherapy alone in terms of DFS.PMID:38693705 | DOI:10.1111/crj.13761 (Source: Respiratory Care)
Source: Respiratory Care - May 2, 2024 Category: Respiratory Medicine Authors: Xiaojie Huang Guanchao Pang Zhirong Mao Baizhou Li Zhihua Teng Yan Yang Zijian Qiu Xiuxiu Chen Pingli Wang Source Type: research
Finding your CAR: The road ahead for engineered T-cells
Am J Pathol. 2024 Apr 30:S0002-9440(24)00162-7. doi: 10.1016/j.ajpath.2024.04.002. Online ahead of print.ABSTRACTAdoptive cellular therapy using chimeric antigen receptors (CAR) has transformed immunotherapy by engineering T cells to target specific antigens on tumor cells. As the field continues to advance, pathology laboratories will play increasingly essential roles in the complicated multi-step process of CAR-T therapy. These include the detection of targetable tumor antigens by flow cytometry or immunohistochemistry at the time of disease diagnosis and the isolation and infusion of CAR-T cells. Additional roles includ...
Source: Am J Pathol - May 2, 2024 Category: Pathology Authors: Po-Han Chen Rianna Raghunandan Jon S Morrow Samuel G Katz Source Type: research
Finding your CAR: The road ahead for engineered T-cells
Am J Pathol. 2024 Apr 30:S0002-9440(24)00162-7. doi: 10.1016/j.ajpath.2024.04.002. Online ahead of print.ABSTRACTAdoptive cellular therapy using chimeric antigen receptors (CAR) has transformed immunotherapy by engineering T cells to target specific antigens on tumor cells. As the field continues to advance, pathology laboratories will play increasingly essential roles in the complicated multi-step process of CAR-T therapy. These include the detection of targetable tumor antigens by flow cytometry or immunohistochemistry at the time of disease diagnosis and the isolation and infusion of CAR-T cells. Additional roles includ...
Source: The American Journal of Pathology - May 2, 2024 Category: Pathology Authors: Po-Han Chen Rianna Raghunandan Jon S Morrow Samuel G Katz Source Type: research
Application of Genomic Medicine in Africa: 14th Conference of the African Society of Human Genetics and the 2nd International Congress of the Moroccan Society of Genomics and Human Genetics, Rabat, Morocco 2022
Am J Trop Med Hyg. 2024 May 2:tpmd230808. doi: 10.4269/ajtmh.23-0808. Online ahead of print.ABSTRACTThe 14th African Society of Human Genetics (AfSHG) Morocco Meeting and 2nd International Congress of the Moroccan Society of Genomics and Human Genetics (SM2GH), held in Rabat, Morocco, from December 12 through 17, 2022, brought together 298 attendees from 23 countries, organized by the AfSHG in collaboration with the SM2GH. The conference's overarching theme was "Applications of Genomics Medicine in Africa," covering a wide range of topics, including population genetics, genetics of infectious diseases, hereditary disorders...
Source: Am J Trop Med Hyg - May 2, 2024 Category: Infectious Diseases Authors: Meryem Fakhkhari Ikram Salih Najwa Maazaz Victoria Nembaware Nchangwi Syntia Munung Alice Matimba Sanaa Chala Ahmed Belmouden Karon Chappell Leon Mutesa Ghada El-Kamah Hicham Oumzil Larbi Baassi Younes Abbas Mohamed Zahir Alimohamed Michele Ramsay Scott W Source Type: research
