Association of pathological response with long-term survival outcomes after neoadjuvant immunotherapy: A meta-analysis
CONCLUSION: Our meta-analysis demonstrates a strong association between pathological response and long-term survival outcomes at patient level across studies applying neoadjuvant immunotherapy in most solid tumors but we fail to validate the relationship at trial level. Therefore, an accepted surrogate endpoint applied to both patient and trial levels are waited for further search.PMID:38685176 | DOI:10.1016/j.intimp.2024.112078 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Chenyu Wei Haolin Sun Jiexuan Hu Zhongjun Ma Bangwei Cao Source Type: research
Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity
Biochem Biophys Res Commun. 2024 Apr 24;715:149995. doi: 10.1016/j.bbrc.2024.149995. Online ahead of print.ABSTRACTImmune checkpoint inhibitors have significantly transformed the landscape of cancer therapy. Nevertheless, while these inhibitors are highly effective for certain patient groups, many do not benefit due to primary or acquired resistance. Specifically, these treatments often lack sufficient therapeutic efficacy against cancers with low antigenicity. Thus, the development of an effective strategy to overcome cancers with low antigenicity is imperative for advancing next-generation cancer immunotherapy. Here, we ...
Source: Biochemical and Biophysical Research communications - April 30, 2024 Category: Biochemistry Authors: Genzui Setsu Megumi Goto Kentaro Ito Tomoe Taira Masaya Miyamoto Tomohiro Watanabe Saito Higuchi Source Type: research
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
Multi-omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma
J Cell Mol Med. 2024 May;28(9):e18339. doi: 10.1111/jcmm.18339.ABSTRACTGlioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional da...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Wenjie Wu Cheng Jiang Wende Zhu Xiaobing Jiang Source Type: research
Multi-omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma
J Cell Mol Med. 2024 May;28(9):e18339. doi: 10.1111/jcmm.18339.ABSTRACTGlioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional da...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Wenjie Wu Cheng Jiang Wende Zhu Xiaobing Jiang Source Type: research
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
Developing theragnostics for Alzheimer's disease: Insights from cancer treatment
Int J Biol Macromol. 2024 Apr 27:131925. doi: 10.1016/j.ijbiomac.2024.131925. Online ahead of print.ABSTRACTThe prevalence of Alzheimer's disease (AD) and its associated economic and societal burdens are on the rise, but there are no curative treatments for AD. Interestingly, this neurodegenerative disease shares several biological and pathophysiological features with cancer, including cell-cycle dysregulation, angiogenesis, mitochondrial dysfunction, protein misfolding, and DNA damage. However, the genetic factors contributing to the overlap in biological processes between cancer and AD have not been actively studied. In ...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Hyun-Ju Lee Hee-Jeong Choi Yoo Joo Jeong Yoon-Hee Na Jin Tae Hong Ji Min Han Hyang-Sook Hoe Key-Hwan Lim Source Type: research
Autophagy-Inducing MoO3-x Nanowires Boost Photothermal-Triggered Cancer Immunotherapy
This study provides a strategy and preliminary elucidation of the mechanism of using MoO3-x nanowires with high oxygen vacancy to induce autophagy and thus enhance photothermal immunotherapy.PMID:38687056 | DOI:10.1002/anie.202404822 (Source: Angewandte Chemie)
Source: Angewandte Chemie - April 30, 2024 Category: Chemistry Authors: Lizhen He Qi Chen Qichen Lu Meijin Yang Bin Xie Tianfeng Chen Xun Wang Source Type: research
Multiomics Analysis of Disulfidptosis Patterns and Integrated Machine Learning to Predict Immunotherapy Response in Lung Adenocarcinoma
CONCLUSION: Our research introduces an innovative prognostic risk model predicated upon disulfidptosis genes for patients afflicted with Lung Adenocarcinoma (LUAD). This model proficiently forecasts the survival rates and therapeutic outcomes for LUAD patients, thereby delineating the high-risk population with distinctive immune cell infiltration and a state of immunosuppression. Furthermore, NAPSA can inhibit the proliferation and invasion capabilities of LUAD cells, thereby identifying new molecules for clinical targeted therapy.PMID:38685772 | DOI:10.2174/0109298673313281240425050032 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Junzhi Liu Huimin Li Nannan Zhang Qiuping Dong Zheng Liang Source Type: research
The Confounding Role of Graft-Versus-Host Disease in Animal Models of Cancer Immunotherapy: A Systematic Review
CONCLUSION: By systematically identifying and mitigating the confounding effects of GVHD, we can significantly improve the predictive validity of preclinical trials, obtain broadly applicable findings, improve the efficiency of drugs, enhance safety profiling, and develop better therapeutic strategies. This approach is crucial in ensuring that the immunotherapeutic strategies developed in the laboratory are reflective of the human physiological response, thereby bridging a critical translational gap in oncological research.PMID:38685841 | DOI:10.34172/aim.2024.24 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Hami Ashraf Mohammad Heydarnejad Farid Kosari Source Type: research
A Meta-Analysis Investigating the Efficacy and Safety of Allergen-Specific Immunotherapy in the Management of Respiratory Allergies
Conclusion: The results of our meta-analysis suggest that specific immunotherapy, while associated with some adverse effects, effectively reduces the symptoms of asthma and rhinitis. Therefore, we recommend its use in the treatment of respiratory allergies.PMID:38687911 | DOI:10.1080/02770903.2024.2349604 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Xue Li Juju Shang Jian Liu Yong Zhu Source Type: research
Association of pathological response with long-term survival outcomes after neoadjuvant immunotherapy: A meta-analysis
CONCLUSION: Our meta-analysis demonstrates a strong association between pathological response and long-term survival outcomes at patient level across studies applying neoadjuvant immunotherapy in most solid tumors but we fail to validate the relationship at trial level. Therefore, an accepted surrogate endpoint applied to both patient and trial levels are waited for further search.PMID:38685176 | DOI:10.1016/j.intimp.2024.112078 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Chenyu Wei Haolin Sun Jiexuan Hu Zhongjun Ma Bangwei Cao Source Type: research
Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of < em > GNAL < /em > in glioma
In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion controlled genes (NOCGs) was performed. Immunohistochemistry was used to evaluate GNAL level in glio...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Zhen Liu Liangwang Yang Zhengxing Xie Hui Yu Tianyi Gu Daoming Shi Ning Cai Shenghua Zhuo Source Type: research
Implications of intestinal microecology and immune function alterations for immunotherapy outcomes in advanced unresectable lung adenocarcinoma
CONCLUSION: The structuring of gut flora plays a pivotal role in augmenting the efficacy of anti-tumor immunotherapy, underscoring the interplay between intestinal microecology and immune response in cancer treatment outcomes.PMID:38685799 | DOI:10.1111/crj.13762 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Shuang He Jin Tian Jianhua Zang Lin Long Peng Liu Yexi Zhang Jun Xiao Source Type: research
ER-associated degradation adapter Sel1L is required for CD8 < sup > + < /sup > T cell function and memory formation following acute viral infection
Cell Rep. 2024 Apr 29;43(5):114156. doi: 10.1016/j.celrep.2024.114156. Online ahead of print.ABSTRACTThe maintenance of antigen-specific CD8+ T cells underlies the efficacy of vaccines and immunotherapies. Pathways contributing to CD8+ T cell loss are not completely understood. Uncovering the pathways underlying the limited persistence of CD8+ T cells would be of significant benefit for developing novel strategies of promoting T cell persistence. Here, we demonstrate that murine CD8+ T cells experience endoplasmic reticulum (ER) stress following activation and that the ER-associated degradation (ERAD) adapter Sel1L is indu...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Luis O Correa-Medero Shayna E Jankowski Hanna S Hong Nicholas D Armas Aditi I Vijendra Mack B Reynolds Garrett M Fogo Dominik Awad Alexander T Dils Kantaro A Inoki Reid G Williams Annabelle M Ye Nadezhda Svezhova Francisco Gomez-Rivera Kathleen L Collins Source Type: research
