Idiopathic pulmonary fibrosis –A challenging disease with new horizons and changing therapeutic landscape
ConclusionThe landscape of IPF management has seen a paradigm shift in the last decade form anti ‐inflammatory to anti‐fibrotic approach and with evidence of slowing disease progression. We are likely to improve IPF management in the near future with multi‐modality and personalised therapy. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 28, 2021 Category: Respiratory Medicine Authors: Ahmed Fahim Tags: REVIEW ARTICLE Source Type: research

Clinical characteristics and aetiological  analysis of 133 patients for pulmonary embolism combined with haemoptysis
AbstractBackgroundIn the patients with pulmonary embolism (PE), PE itself can cause haemoptysis and other reasons can also cause haemoptysis. Therefore, the clinical  characteristics and the causes of haemoptysis are lacking.MethodsA retrospective  analysis was performed that involved screening 583 PE patients and determining that haemoptysis occurred in 141 cases. Of these, eight cases were omitted due to anticoagulation‐related haemoptysis or unavailable data, leaving 133 cases that were enrolled in final analysis (127 acute and 6 chron ic case of PE). We classified the acute PE patients who combined wit...
Source: The Clinical Respiratory Journal - January 27, 2021 Category: Respiratory Medicine Authors: Yong Wei Zou, Jun Duan, Xiao ‐Hui Wang, Huan Huan Yang, Jing Chi, Hong Chen Tags: ORIGINAL ARTICLE Source Type: research

Association Between Insulin Resistance and BMI with FEV1 in Non ‐Hypoxemic COPD Out‐patients
This study was conducted to determine impact of insulin resistance using Homeostatic Model Assessment of Insulin Resistance (HOMA ‐IR) score and BMI in non‐hypoxemic out‐patients with COPD on FEV1 using linear and polynomial regressions and to determine their correlation.MethodsCOPD patients of both genders were included after informed consent. Fasting blood sugar and serum insulin were done to calculate HOMA ‐IR, which were segregated into two groups of ≥ 3 and
Source: The Clinical Respiratory Journal - January 26, 2021 Category: Respiratory Medicine Authors: Faisal Faiyaz Zuberi, Nimrah Bader, Tazeen Rasheed, Bader Faiyaz Zuberi Tags: ORIGINAL ARTICLE Source Type: research

Construct Validity of the Brief Physical Activity Assessment Tool for Clinical Use in COPD
This study assessed the construct validity of the Brief Physical Activity Assessment Tool (BPAAT) for clinical use in COPD, and explored differences in age, sex and COPD grades.MethodsAfter linguistic adaptation of the tool to Portuguese, 110 patients (66.4 ±9.6yrs, 72.7% male, FEV1=59.3 ±25.5%predicted) completed the BPAAT and received an accelerometer. The BPAAT includes two questions assessing the weekly frequency and duration of vigorous‐ and moderate‐intensity PA/walking, classifying individuals as insufficiently or sufficiently active. The BPAAT was correlated with accele rometry (moderate PA, MPA=1...
Source: The Clinical Respiratory Journal - January 23, 2021 Category: Respiratory Medicine Authors: Joana Cruz, Cristina J ácome, Ana Oliveira, Cátia Paixão, Patrícia Rebelo, Sofia Flora, Filipa Januário, Carla Valente, Lília Andrade, Alda Marques Tags: ORIGINAL ARTICLE Source Type: research

A Review of Venous Thromboembolism in COVID ‐19: In a Clinical Perspective
AbstractCoronavirus Disease ‐19 (COVID‐19) started in Wuhan, China in December 2019 and spread to all around the world in a short period of time. Hospitalized patients with COVID‐19 mostly could suffer from an abnormal coagulation activation risk with increased venous thrombosis events and a poor clinical course. The re ported incidence rates of thrombotic complications in hospitalized COVID‐19 patients vary between 2.6 to 85% (both in non‐critically ill and critically ill patients). The risk of venous thromboembolism is not known in non‐hospitalized patients with COVID‐19 patients. There are numerous st...
Source: The Clinical Respiratory Journal - January 23, 2021 Category: Respiratory Medicine Authors: Savas Ozsu, Ersin Gunay, Stavros V. Konstantinides Tags: ORIGINAL ARTICLE Source Type: research

Association between p73 G4C14 ‐to‐A4T14 polymorphism and lung cancer risk: a systematic review and meta‐analysis
ConclusionOur meta ‐analysis confirms that G4C14‐to‐A4T14 is not significantly related to lung cancer risk. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 23, 2021 Category: Respiratory Medicine Authors: Fenghua Du, Xiaojun Wang, Dandan Qin, Rongjun Zhu, Weibo Kong, Xiangzhou Kong, Xuhong Min Tags: ORIGINAL ARTICLE Source Type: research

Should ct be used for the diagnosis of RT ‐PCR negative suspected COVID‐19 patients?
Conclusion: The diagnostic value of CT in RT‐PCR negative patients with suspected COVID‐19 is not very high. Based on clinical, laboratory, and chest x‐ray findings, it may be more appropriate to refer patients to CT after the first triage, when necessary. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 23, 2021 Category: Respiratory Medicine Authors: G ünay Rona, Meral Arifoğlu, Nuray Voyvoda, Ayşe Batırel Tags: ORIGINAL ARTICLE Source Type: research

Adhesion Molecules as Diagnostic and Severity Biomarkers in Pediatric Community ‐Acquired Pneumonia
ConclusionsBesides classical acute phase parameters, inflammatory response parameters such as IL6 and VCAM ‐1 levels may be helpful in diagnosis of pneumonia. In terms of determination of disease severity in pediatric CAP, systemic inflammatory markers like IL8 and IL10 and adhesion molecules like sSELE seem useful in clinical settings. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 23, 2021 Category: Respiratory Medicine Authors: Sevgen Tan ır Basaranoglu, Yasemin Ozsurekci, Kubra Aykac, Irem Iyigun, Ozlem Satirer, Mustafa Senol Akin, Mehmet Ceyhan Tags: ORIGINAL ARTICLE Source Type: research

Development of SARS ‐CoV‐2 Rapid Antibody Detection Kit and Study on Dynamic Changes in Antibodies in Infected Patients
ConclusionThe sensitivities of the SARS ‐CoV‐2 IgM/IgG antibody test kit (Colloidal Gold Method) were 50%, 70%, 92.5%, and 97.5% after 1‐3 days, 4‐6 days, 7‐9 days, and> 9 days after admission, and the specificities of the IgM, IgG, and IgM + IgG antibodies were all 100%. Using the SARS ‐CoV‐2 IgM/IgG antibody test kit (Colloidal Gold Method), the positive rates of SARS‐CoV‐2 IgM and IgG antibodies increased from 50% to 92.5% after 1‐3 days, 4‐6 days, and 7‐9 days of admission, which showed an increasing trend. The titers of the SARS‐CoV‐2 IgM and IgG antibodies i n the positive specimens inc...
Source: The Clinical Respiratory Journal - January 23, 2021 Category: Respiratory Medicine Authors: Huihui Wang, Xuemei Li, Tao Li, Lianzi Wang, Li Wang, Jiawang Lin, Shubing Zhang, Yuanhong Xu, Wei Wei Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 15, Issue 1, Page 1-2, January 2021. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 21, 2021 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

The applicability of the Global Lung Initiative equations and other regional equations on a sample of healthy Middle Eastern adolescents.
ConclusionSpirometry reference equations formulated for Jordanian adolescents may improve the diagnosis and treatment of asthma in Jordan. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 20, 2021 Category: Respiratory Medicine Authors: Walid Al ‐Qerem, Ameen Alassi, Anan S. Jarab, Jonathan Ling Tags: ORIGINAL ARTICLE Source Type: research

The relationships between serum Heart ‐type Fatty Acid Binding Protein and right ventricular echocardiographic indices in Chronic Obstructive Pulmonary Disease
In this study, we assessed the relationships between serum H‐FABP as a marker of cardiac injury and right ventricle (RV) echocardiographic indices in patients with stable COPD.Materials and MethodsIn this case ‐control study, 84 participants were investigated (50 COPD patients and 34 healthy subjects). After obtaining consent, 3 ml fasting whole blood sample was collected from each of the participants to test their serum H‐FABP. Echocardiography was performed on all participants by cardiologists.ResultsSerum H ‐FABP was found to be significantly correlated with smoking history (P
Source: The Clinical Respiratory Journal - January 12, 2021 Category: Respiratory Medicine Authors: Leili Avesta, Mohammad Reza Aslani, Parastoo Parham, Saeid Sadeghieh ‐Ahari, Hassan Ghobadi Tags: ORIGINAL ARTICLE Source Type: research

Successfully managed combined pulmonary fibrosis and emphysema in a lung large cell neuroendocrine carcinoma patient treated with pembrolizumab
The Clinical Respiratory Journal, Accepted Article. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 11, 2021 Category: Respiratory Medicine Authors: Katsunori Kagohashi, Hiroaki Satoh Tags: LETTER TO THE EDITOR Source Type: research

Validation of PSI/PORT, CURB ‐65 and SCAP scoring system in COVID‐19 pneumonia for prediction of disease severity and 14‐day mortality
ConclusionThe PSI/PORT scoring system, the CURB ‐65 criteria and the SCAP scoring system can be used to assess the COVID‐19 severity and predict the 14‐day mortality risk in cases of COVID‐19 pneumonia. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 8, 2021 Category: Respiratory Medicine Authors: A. Anurag, M. Preetam Tags: ORIGINAL ARTICLE Source Type: research

Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma
ConclusionPersistent SABA ‐induced FEV1>12%, especially when associated to BE>300 cells/mL, may be a marker of accelerated lung function decline in severe asthmatics despite maximal step ‐5 treatment. The highest bronchodilation associated to the lowest BE levels should be the main goal of asthma treatment to prevent such decline. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 5, 2021 Category: Respiratory Medicine Authors: Bruno Sposato, Marco Scalese, Alberto Ricci, Paola Rogliani, Pierluigi Paggiaro, The Omalizumab Italian Study Group Tags: BRIEF REPORT Source Type: research

Idiopathic Pulmonary Fibrosis (IPF) ‐ A challenging disease with New Horizons and changing therapeutic landscape
ConclusionThe landscape of IPF management has seen a paradigm shift in the last decade form anti ‐inflammatory to anti‐fibrotic approach and with evidence of slowing disease progression. We are likely to improve IPF management in the near future with multi‐modality and personalized therapy. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 5, 2021 Category: Respiratory Medicine Authors: Ahmed Fahim Tags: REVIEW ARTICLE Source Type: research

Reminiscence therapy ‐based care program relieves anxiety, depression and improvs quality of life in post‐operational non‐small cell lung cancer patients
ConclusionRTCP effectively relieves anxiety and depression, improvs QoL, but did not prolong survival, suggesting its value as a non ‐pharmacological approach for post‐operational NSCLC management. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 5, 2021 Category: Respiratory Medicine Authors: Meifang Liu, Yao Li Tags: ORIGINAL ARTICLE Source Type: research

Efficacy of endobronchial ultrasound ‐guided‐transbronchial biopsy without guide sheath for small peripheral pulmonary lesions (≤15 mm): A retrospective cohort study
ConclusionsEBUS ‐TBB without GS is an effective and safe procedure for diagnosing small PPLs (≤15 mm) compared to that with GS. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 4, 2021 Category: Respiratory Medicine Authors: Takayasu Ito, Masami Matsumoto, Mihoko Kujime, Takashi Kohnoh, Akira Fukushima, Tatsuya Takagi, Yukiko Fukushima, Takaaki Kasahara Tags: ORIGINAL ARTICLE Source Type: research

High ‐flow nasal cannula oxygen versus conventional oxygen for hypercapnic chronic obstructive pulmonary disease: A meta‐analysis of randomized controlled trials
ConclusionsOur meta ‐analysis showed no difference in PO2 and PCO2 between the HFNC and conventional oxygen. But we should treat this conclusion with caution because the number of studies and participants is small and, there is heterogeneity in the PaO2 and PCO2 measurements between stable and AECOPD. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 28, 2020 Category: Respiratory Medicine Authors: Xuan Huang, Yanping Du, Zhiyi Ma, Huaping Zhang, Liu Jun, Zhiyong Wang, Meixia Lin, Fayu Ni, Xi Li, Hui Tan, Shifan Tan Tags: ORIGINAL ARTICLE Source Type: research

Mean platelet volume may not change in chronic obstructive pulmonary disease patients with pulmonary heart disease
The Clinical Respiratory Journal, Accepted Article. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 23, 2020 Category: Respiratory Medicine Authors: Cengiz Beyan, Esin Beyan Tags: LETTER TO THE EDITOR Source Type: research

Endobronchial ultrasound guided transbronchial cryobiopsy versus forceps biopsy in peripheral lung lesions
ConclusionsRP ‐EBUS‐guided TBCB is a safe and effective technique for diagnosis of peripheral lung lesions. TBCB has achieved higher diagnostic values and better quality of samples. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 19, 2020 Category: Respiratory Medicine Authors: Mohamed Torky, Wafaa S. Elshimy, Mohamed AE. Ragab, Ghada A. Attia, Raquel Lopez, Jose Luis Mate, Carmen Centeno, Pere Serra, Rachid Tazi Mezalek, Eli Nancy P érez, Juan Ruiz Manzano, Antonio Rosell, Felipe Andreo Tags: ORIGINAL ARTICLE Source Type: research

Determination of the minimal important difference for Dyspnoea ‐12 questionnaire in patients with COPD, after pulmonary rehabilitation
AbstractIntroductionThe authors of the international task force about the management of Dyspnoea recommend assessing sensory and affective components of dyspnoea. The Dyspnoea ‐12 questionnaire (D‐12) allows to assess both components of dyspnoea. D‐12 is valid and reliable but its sensitivity to pulmonary rehabilitation was not studied. The aim of this study was to estimate the minimal important difference (MID) for D‐12 in COPD patients undergoing a pulmonary reh abilitation programme (PRP).MethodsSevere or very severe COPD patients undergoing a PRP were included. Dyspnoea was assessed using D ‐12, MMRC dyspnoea...
Source: The Clinical Respiratory Journal - December 18, 2020 Category: Respiratory Medicine Authors: Marc Beaumont, M élanie Le Garrec, Loic Péran, Anne‐Cécile Berriet, Catherine Le Ber, Romain Pichon, Michel Cabillic Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 14, Issue 12, Page 1111-1112, December 2020. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 15, 2020 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Endocan as a Potential Biomarker of Disease Severity and Exacerbations in COPD
This study aimed to determine serum endocan levels in patients with stable COPD and acute exacerbation of COPD (AECOPD) and to test the relationship between serum endocan levels and exacerbations.MethodsThis study enrolled a total of 55 COPD patients, 24 of which had AECOPD and 31 had stable COPD. All patients ’ basic demographic and clinical data were recorded and blood samples were collected.ResultsSerum endocan levels were significantly higher in the AECOPD group compared to the stable COPD and control groups (for both p
Source: The Clinical Respiratory Journal - December 14, 2020 Category: Respiratory Medicine Authors: Erdal İn, Mutlu Kuluöztürk, Teyfik Turgut, Ayşegül Altıntop Geçkil, Nevin İlhan Tags: ORIGINAL ARTICLE Source Type: research

The value of bronchoscopy in patients with non ‐massive haemoptysis and a clear or benign computer tomogram scan
ConclusionFOB provides minimal value for identifying lung malignancies in patients with non ‐massive haemoptysis and a clear or benign CT scan irrespective of patient‐specific risk factors. Cost savings would be associated if physicians altered practice accordingly. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 10, 2020 Category: Respiratory Medicine Authors: Avinash Aujayeb, Declan C Murphy, Karl Jackson, Robert Johnston, Sarah Welsh, Rebecca Webster, Rebecca Lapsley, Hussun ‐Ara Shah, Daniel Mitchell Tags: ORIGINAL ARTICLE Source Type: research

High ‐Flow Nasal Cannula Oxygen versus Conventional Oxygen for Chronic Obstructive Pulmonary Disease: a Meta‐analysis of Randomized Controlled Trails
ConclusionsOur meta ‐analysis showed no difference in PO2 and PCO2 between the HFNC and conventional oxygen. But we should treat this conclusion with caution because the number of studies and participants is small and, there is heterogeneity in the PaO2 and PCO2 measurements between stable and AECOPD. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 6, 2020 Category: Respiratory Medicine Authors: Xuan Huang, Yanping Du, Zhiyi Ma, Huaping Zhang, Liu Jun, Zhiyong Wang, Meixia Lin, Fayu Ni, Xi Li, Hui Tan, Shifan Tan Tags: ORIGINAL ARTICLE Source Type: research

Determination of the minimal important difference for Dyspnea ‐12 questionnaire in patients with COPD, after pulmonary rehabilitation.
AbstractIntroductionThe authors of the international task force about the management of Dyspnea recommend assessing sensory and affective components of dyspnea. The Dyspnea ‐12 questionnaire (D‐12) allows to assess both components of dyspnea. D‐12 is valid and reliable but its sensitivity to pulmonary rehabilitation was not studied.The aim of this study was to estimate the minimal important difference (MID) for D ‐12 in COPD patients undergoing a pulmonary rehabilitation program (PRP).MethodsSevere or very severe COPD patients undergoing a PRP were included. Dyspnea was assessed using D ‐12, MMRC dyspnea scale, L...
Source: The Clinical Respiratory Journal - December 5, 2020 Category: Respiratory Medicine Authors: Marc Beaumont, M élanie Le Garrec, Loic Péran, Anne Cécile Berriet, Catherine Le Ber, Romain Pichon, Michel Cabillic Tags: ORIGINAL ARTICLE Source Type: research

Validity of the Brazilian version of the COPD assessment test in patients with chronic obstructive pulmonary disease
AbstractIntroductionCOPD Assessment Test (CAT) is a questionnaire defined as one of the main options in the assessment of the impact of Chronic Obstructive Pulmonary Disease on patients ’ life, according to the Global Initiative on Obstructive Lung Diseases. However, the Consensus‐based Standards for the Selection of Health Measurement Instruments—COSMIN 2018 has recently determined a correlation coefficient greater than 0.70 and an optimal sample size must have a hundred sub jects, hence, validity of the Brazilian version of this instrument is still not yet proven.ObjectiveTo verify the validity of the Brazi...
Source: The Clinical Respiratory Journal - December 4, 2020 Category: Respiratory Medicine Authors: Mariana Pereira Flores, Juliano Ferreira Arcuri, Marcela Maria Carvalho da Silva, Val éria Amorim Pires Di Lorenzo Tags: ORIGINAL ARTICLE Source Type: research

Comparison of high ‐flow oxygenation with noninvasive ventilation in COPD exacerbation: A crossover clinical trial
ConclusionIn this short ‐term study HFT appears feasible for patients with COPD exacerbation to reduce dyspnea score and improve respiratory distress. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 2, 2020 Category: Respiratory Medicine Authors: Abbs Rezaee, Atefeh Fakharian, Fariba Ghorbani, Esmaeeil Idani, Atefeh Abedini, Hamidreza Jamaati Tags: ORIGINAL ARTICLE Source Type: research

Epicardial Adipose Tissue is Associated with Increased Systolic Pulmonary Artery Pressure in Patients with Chronic Obstructive Pulmonary
AbstractObjectivesPulmonary hypertension (PHT) is one of the essential predictors of mortality in chronic obstructive pulmonary disease (COPD). It is thought that PHT is due to vasoconstriction secondary to hypoxia caused by airway obstruction in COPD patients; however, loss of capillary bed with emphysema, inflammation and endothelial dysfunction may also play a role in the development of PHT. Epicardial adipose tissue (EAT) has a role as a metabolically active endocrine organ and secretes various proinflammatory cytokines. We hypothesized that EAT thickness in COPD patients might be associated with the systolic pulmonary...
Source: The Clinical Respiratory Journal - December 2, 2020 Category: Respiratory Medicine Authors: Ezgi Kalayc ıoğlu, Mustafa Çetin, Göksel Çinier, Ali Gökhan Özyıldız, İsmet Durmuş, Tuncay Kırış, Tayyar Gökdeniz Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of the relationship of neutrophil ‐to lymphocyte ratio and platelet‐to‐lymphocyte ratio with in‐hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease
AbstractIntroductionAcute exacerbation of chronic obstructive pulmonary disease (AECOPD) has the highest mortality rate and medical costs. The neutrophil ‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte (PLR) ratio are inflammatory markers that have been recently linked to the AECOPD severity and patient outcome.ObjectiveTherefore, the present study aimed at evaluating the diagnostic value of NLR and PLR in the prognosis of the in ‐hospital mortality in AECOPD patients.MethodsThe present retrospective study was performed on 829 AECOPD patients. Age, gender and laboratory results of CBC tests including lympho...
Source: The Clinical Respiratory Journal - December 1, 2020 Category: Respiratory Medicine Authors: Mohammad Emami Ardestani, Nooshin Alavi ‐Naeini Tags: ORIGINAL ARTICLE Source Type: research

Major histocompatibility complex class II polymorphic variants are associated with asthma predisposition in the Punjabi population of Lahore, Pakistan
ConclusionThis study reports association of SNP variants residing on HLA ‐DQB1 and HLA‐DQA2 genes and haplotypes H7 and H13 on genomic region 6p21 with Asthma in the Punjabi population of Lahore, Pakistan. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 30, 2020 Category: Respiratory Medicine Authors: Raheela Aslam, Mariam Shahid, Iqbal Bano, Muhammad Ayoub, Muhammad Farooq Sabar, Saba Altaf, Samra Kousar, Muhammad Usman Ghani, Tayyab Husnain, Ahmad Ali Shahid Tags: Original Article Source Type: research

Role of Systemic Immune ‐Inflammation Index in Asthma and NSAID‐Exacerbated Respiratory Disease
ConclusionThis is the first study to evaluate SII as a tool for differentiating asthma phenotypes. The presence of SII below the cut ‐off value can help exclude the diagnosis of NERD. There is a need for large‐scale prospective studies to compare different phenotypes and determine the optimal cut‐off value. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 29, 2020 Category: Respiratory Medicine Authors: Tuba Erdo ğan Tags: ORIGINAL ARTICLE Source Type: research

Association of quantitative CT lung density measurements and lung function decline in World Trade Center workers
ConclusionsLongitudinal FEV1 decline in this cohort, known to be associated with QCT proximal airway inflammation metric, is also associated with QCT indicators of increased and decreased lung density. The improved FEV1 trajectory did not seem to be associated with lung density metrics. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 26, 2020 Category: Respiratory Medicine Authors: Xiaoyu Liu, Anthony P. Reeves, Katherine Antoniak, Ra úl San José Estépar, John T. Doucette, Yunho Jeon, Jonathan Weber, Dongming Xu, Juan C. Celedón, Rafael E. de la Hoz Tags: ORIGINAL ARTICLE Source Type: research

The influence of cognitive load on static balance in chronic obstructive pulmonary disease patients
ConclusionCompared to healthy controls, the COPD patients had impaired balance. Cognitive tasks altered postural control in both COPD and controls, where this alteration was more pronounced with eyes closed. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 20, 2020 Category: Respiratory Medicine Authors: Olivier Van Hove, Ana Maria Cebolla, Vasileios Andrianopoulos, Dimitri Leduc, Pierre Antoine Guidat, V éronique Feipel, Gaël Deboeck, Bruno Bonnechère Tags: ORIGINAL ARTICLE Source Type: research

Knowledge of obstructive sleep apnoea in final year medical students and junior doctors ‐a multi‐centre cross‐sectional study
ConclusionFinal year medical students and junior doctors from a sample of four university teaching hospitals in three large cities of Pakistan have limited knowledge about the diagnosis and management of OSA. The observed limited knowledge of OSA may contribute towards under ‐diagnosis of this increasingly prevalent medical condition. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 20, 2020 Category: Respiratory Medicine Authors: Gull Afshan Zaidi, Syed Tabish Rehman, Muhammad Mudassir Shafiq, Talat Zehra, Muhammad Israar, Syed Mazher Hussain Tags: ORIGINAL ARTICLE Source Type: research

Epidemiology and Issues of NIV ‐treated AECOPD Patients with Hypercapnic Respiratory Failure in Shanghai: A Multicenter Retrospective Survey
AbstractObjectiveTo investigate the epidemiology, clinical features, treatment and outcome of Noninvasive ventilation (NIV) ‐treated acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients in secondary hospitals of Shanghai.MethodRelying on Shanghai alliances for respiratory diseases, a retrospective observational study was performed in 34 secondary hospitals of Shanghai. The AECOPD patients treated with NIV and admitted to the respiratory department or respiratory intensive care unit were recruited between December 1, 2016 and November 30, 2017.ResultsThe 555 patients were finally recruited in this...
Source: The Clinical Respiratory Journal - November 20, 2020 Category: Respiratory Medicine Authors: Sheng ‐mei Wang, Feng‐ying Zhang, Chun‐ling Du, Xiong‐biao Wang, Fan Li, Jing‐qing Hang, Yuan‐jing Chen, Ke‐wen Cheng, Lei Zhao, Xiao‐yan Jin, Jin‐dong Shi, Zhi‐jun Jie, Jie‐ming Qu, The Shanghai Primary Respiratory Care Tags: ORIGINAL ARTICLE Source Type: research

Vitamin D deficiency is associated with chronic obstructive pulmonary disease and exacerbation of COPD
AbstractIntroductionLow Vitamin D levels have been associated with Chronic Obstructive Pulmonary Disease (COPD) and acute exacerbations.ObjectivesThere is paucity of data on vitamin D and COPD, its severity and exacerbations in populations that are exposed to sunlight regularly with high levels of physical activity most of their lives.MethodsSerum levels of 25 ‐OH‐Vitamin‐D was assessed in 100 COPD subjects and 100 age‐ and gender‐matched controls from the rural community based MUDHRA cohort in South India. Levels of
Source: The Clinical Respiratory Journal - November 20, 2020 Category: Respiratory Medicine Authors: Komarla Sundararaja Lokesh, Sindaghatta Krishnarao Chaya, Biligere Siddaiah Jayaraj, Praveena Attahalli Shivanarayanprasad, Murali Krishna, Purnima Madhivanan, Mahesh Anand Padukudru Tags: ORIGINAL ARTICLE Source Type: research

Validity of the Brazilian version of the copd assessment testin patients with chronic obstructive pulmonary disease
AbstractIntroductionCOPD Assessment Test (CAT) is a questionnaire defined as one of the main options in the assessment of the impact of Chronic Obstructive Pulmonary Disease on patients ’ life, according to the Global Initiative on Obstructive Lung Diseases. However the Consensus‐based Standards for the Selection of Health Measurement Instruments — COSMIN 2018 has recently determined a correlation coefficient greater than 0.70, and an optmal sample size must have a hundred su bjects, hence, validity of the Brazilian version of this instrument is still not yet proven.ObjectiveTo verify the validity of the Braz...
Source: The Clinical Respiratory Journal - November 19, 2020 Category: Respiratory Medicine Authors: Mariana Pereira Flores, Juliano Ferreira Arcuri, Marcela Maria Carvalho da Silva, Val éria Amorim Pires Di Lorenzo Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of the relationship of neutrophil ‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio with in‐hospital mortality in patients with acute exacerbation of COPD
AbstractIntroductionAcute exacerbation of chronic obstructive pulmonary disease (AECOPD) has the highest mortality rate and medical costs. The neutrophil ‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte (PLR) ratio are inflammatory markers that have been recently linked to the AECOPD severity and patient outcome.ObjectiveTherefore, the present study aimed at evaluating the diagnostic value of NLR and PLR in the prognosis of the in ‐hospital mortality in AECOPD patients.MethodsThe present retrospective study was performed on 829 AECOPD patients. Age, gender, and laboratory results of CBC tests including lymph...
Source: The Clinical Respiratory Journal - November 19, 2020 Category: Respiratory Medicine Authors: Mohammad Emami Ardestani, Nooshin Alavi ‐Naeini Tags: ORIGINAL ARTICLE Source Type: research

“Major Histocompatibility Complex class II Polymorphic variants are associated with Asthma predisposition in the Punjabi population of Lahore, Pakistan”
ConclusionThis study reports association of SNP variants residing on HLA ‐DQB1 and HLA‐DQA2 genes and haplotypes H7 and H13 on genomic region 6p21 with Asthma in the Punjabi population of Lahore, Pakistan. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 19, 2020 Category: Respiratory Medicine Authors: Raheela Aslam, Mariam Shahid, Iqbal Bano, Muhammad Ayoub, Muhammad Farooq Sabar, Saba Altaf, Samra Kousar, Muhammad Usman Ghani, Tayyab Husnain, Ahmad Ali Shahid Tags: ORIGINAL ARTICLE Source Type: research

Chronic obstructive pulmonary disease research by using big data
AbstractAs the information technology develops, large amount of data has been stored. The digitalization of the health ‐care system enables researchers to use big data easily. Big data has been utilized for valuable source for chronic obstructive pulmonary disease (COPD) research. Various sources of data are now available including nationwide claim data and primary care database. Recently web data is also used in COPD research. Each different data source has strengths and weaknesses. Merging different data can overcome the limitation of big data research. Future direction of big data research is to integrate multiple big...
Source: The Clinical Respiratory Journal - November 18, 2020 Category: Respiratory Medicine Authors: Chin Kook Rhee Tags: REVIEW ARTICLE Source Type: research

Forced oscillation measurements in patients after lobectomy – A comparative analysis with IPF and COPD patients
AbstractObjectivesForced oscillation technique (FOT) is becoming increasingly widespread measurement method used for assessment of lung function. In the present study, we attempted to assess FOT values in patients after lobectomy in comparison with IPF and COPD patients.MethodsTwenty ‐two patients after lobectomy due to lung cancer stage I or II, 28 patients with idiopathic pulmonary fibrosis and 17 patients with chronic obstructive pulmonary disease were enrolled in the study. All patients performed spirometry (FEV1, FVC, FEV1/FVC, MEF50, MEF25, FEF25 ‐75, MIF50), plethysmography (Raw, TLC, RV, RV/TLC) and a test usin...
Source: The Clinical Respiratory Journal - November 16, 2020 Category: Respiratory Medicine Authors: Sabina Kostorz ‐Nosal, Dariusz Jastrzębski, Dariusz Ziora Tags: ORIGINAL ARTICLE Source Type: research

Prognosis After Acute Exacerbation in Patients with Interstitial Lung Disease Other than Idiopathic Pulmonary Fibrosis
AbstractBackgroundAcute exacerbation (AE) is recognized as a life ‐threatening condition with acute respiratory worsening in idiopathic pulmonary fibrosis (IPF). AE also occurs in fibrotic interstitial lung disease (ILD) other than IPF, including other types of idiopathic interstitial pneumonias (IIPs), ILD associated with collagen vascular disease (CVD‐ILD) a nd chronic hypersensitivity pneumonia (CHP). However, the clinical impact after AE in those patients is still unclear.MethodsA retrospective review of 174 consecutive first ‐episodes with AE of ILD in our institution from 2002 to 2016 was performed. AE was defi...
Source: The Clinical Respiratory Journal - November 16, 2020 Category: Respiratory Medicine Authors: Koichi Miyashita, Masato Kono, Go Saito, Yu Koyanagi, Akari Tsutsumi, Takeshi Kobayashi, Yoshihiro Miki, Dai Hashimoto, Yutaro Nakamura, Takafumi Suda, Hidenori Nakamura Tags: ORIGINAL ARITCLE Source Type: research

No changes in nocturnal respiration with hypoglossal neurostimulation therapy for obstructive sleep apnea
ConclusionWe did not observe significant changes in AHI and ODI4 indices with HGNS therapy. Larger multicenter randomized controlled trials are necessary before wider international use of HGNS. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 13, 2020 Category: Respiratory Medicine Authors: Adel Bachour, Leif B äck, Petra Pietarinen Tags: ORIGINAL ARTICLE Source Type: research

Clinical predictors of COVID ‐19 disease progression and death: Analysis of 214 hospitalised patients from Wuhan, China
ConclusionsThese findings provide insights for early detection and management of patients at risk of disease progression or even death, especially older patients and those with comorbidities. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 8, 2020 Category: Respiratory Medicine Authors: Jie Liu, Zilong Liu, Weipeng Jiang, Jian Wang, Mengchan Zhu, Juan Song, Xiaoyue Wang, Ying Su, Guiling Xiang, Maosong Ye, Jiamin Li, Yong Zhang, Qinjun Shen, Zhuozhe Li, Danwei Yao, Yuanlin Song, Kaihuan Yu, Zhe Luo, Ling Ye Tags: ORIGINAL ARTICLE Source Type: research

Corrigendum
The Clinical Respiratory Journal, Volume 14, Issue 11, Page 1109-1109, November 2020. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 5, 2020 Category: Respiratory Medicine Tags: CORRIGENDUM Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 14, Issue 11, Page 999-1000, November 2020. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 5, 2020 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

The Association between Outcomes and Body Mass Index in Patients with Acute Respiratory Distress Syndrome
AbstractIntroductionLimited information exists about the relationship between body mass index (BMI) and the outcome of acute respiratory distress syndrome (ARDS).ObjectiveTo evaluate the hospital mortality of patients with ARDS in relation to BMI.Materials and MethodsWe conducted a retrospective, multicenter study including patients with ARDS. ARDS was defined according to the Berlin criteria. Body weight and height were obtained to calculate BMI. The primary outcome was in ‐hospital mortality. Secondary outcomes were intensive care unit (ICU) mortality, invasive positive pressure ventilation (IPPV) free days within 28 d...
Source: The Clinical Respiratory Journal - November 3, 2020 Category: Respiratory Medicine Authors: Ziying Chen, Xu Huang, Haining Lu, Wang Deng, Linna Huang, Dawei Wu, Daoxin Wang, Qingyuan Zhan Tags: ORIGINAL ARTICLE Source Type: research

The combination of pretreatment prognostic nutritional index and neuron ‐specific enolase enhances prognosis predicting value of small cell lung cancer
AbstractIntroductionTumor and immune ‐inflammatory biomarkers have been demonstrated to be closely associated with cancer prognosis.ObjectiveThe present study aims to assess the prognostic value of pretreatment prognostic nutritional index (PNI), carcinoembryonic antigen (CEA), and neuron ‐specific enolase (NSE) in small cell lung cancer (SCLC).MethodsA retrospective analysis of 301 SCLC patients treated with platinum ‐based chemotherapy was performed. Overall survival (OS) was assessed by Kaplan–Meier and multivariate Cox hazard analyses.ResultsThe median OS for total cases was 15.0  months. On univariate...
Source: The Clinical Respiratory Journal - November 1, 2020 Category: Respiratory Medicine Authors: Chunyan Wang, Shi Jin, Shanqi Xu, Shoubo Cao Tags: ORIGINAL ARTICLE Source Type: research