Comparison of heated humidified high flow nasal cannula and nasal continuous positive airway pressure after surfactant administration in preterm neonates with respiratory distress syndrome
ConclusionBased on the results of the present study, the HHHFNC can be as effective as NCPAP to treat the neonates with RDS after surfactant administration. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - June 1, 2020 Category: Respiratory Medicine Authors: Zahra Akbarian ‐rad, Avishan Mohammadi, Soraya Khafri, Mousa Ahmadpour‐kacho, Yadollah Zahed‐pasha, Mohsen Haghshenas‐Mojaveri Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term prognosis of adolescent and middle‐aged Chinese patients with low‐medium risk community‐acquired pneumonia: a cohort study
ConclusionThe long ‐term mortality rate is higher among patients with CAP compared with the age‐adjusted general population in the same city. Age, comorbidity and initial PSI class are independently prognostic factors for the long‐term mortality rate. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 31, 2020 Category: Respiratory Medicine Authors: Hongjun Yin, Shengfeng Wang, Jiuxin Qu, Fei Zhou, Chen Wang, Bin Cao, For CAP ‐China Tags: ORIGINAL ARTICLE Source Type: research

Risk Factors of Radiation Pneumonitis in Patients with NSCLC Treated with Concomitant Chemoradiotherapy ‐Are We Underestimating Diabetes?‐Turkish Oncolog Group/Lung Cancer Study Group
ConclusionsIn our study, besides the known dosimetric factors, DM was found to be the most important risk factor causing RP development in multivariate analysis and RPA.The risk is tripled compared to patients without DM. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 29, 2020 Category: Respiratory Medicine Authors: Sefika Arzu Ergen, Fazilet Oner Dincbas, Birsen Yucel, Pelin Alt ınok, Serap Akyurek, Esra Korkmaz Kıraklı, Sukran Ulger, Durmus Etiz, Ufuk Yilmaz, Diclehan Kılıc, Hakan Bozcuk Tags: ORIGINAL ARTICLE Source Type: research

Association of Serum Ferritin and Lung Function in Tobacco ‐naïve Post‐menopausal Women: Analysis of Population‐based Nationally Representative Data
ConclusionsHigh serum ferritin level was significantly associated with lower FVC% and increased risk of restrictive lung disease in tobacco ‐naïve post‐menopausal women. Further study is needed to determine the mechanism underlying the current findings. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 27, 2020 Category: Respiratory Medicine Authors: Taeyun Kim, Hyunji Choi, Jihun Kang Tags: ORIGINAL ARTICLE Source Type: research

Mechanical ventilation for acute respiratory failure due to idiopathic pulmonary fibrosis versus connective tissue disease ‐associated interstitial lung disease: effectiveness and risk factors for death
ConclusionBased on current clinical practice in three ICUs, the mortality rate in IPF patients receiving MV might reach 86% and is higher than in CTD ‐ILD patients. IMV might be initiated cautiously, especially in patients with disease progression as the principal cause of acute respiratory failure. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 27, 2020 Category: Respiratory Medicine Authors: Zujin Luo, Liu Yang, Sijie Liu, Yuhan Hu, Zhixin Cao, Jian Zhu, Jing Wang, Yingmin Ma Tags: ORIGINAL ARTICLE Source Type: research

The Effects of Home Noninvasive Ventilation on The Quality Of Life and Physiological Parameters of Patients with Chronic Respiratory Failure
AbstractIntroductionHome noninvasive mechanical ventilation (HNIV) in patients with chronic hypercapnic respiratory failure (CHRF) may improve the health related quality of life (HRQL) and reduce hospitalizations.ObjectiveTo determine the effects of HNIV on HRQL, sleep quality and hospitalization rates in restrictive thoracic diseases (RTD) and COPD patients with CHRF.MethodsIn this prospective, single center study patients divided into two groups; the COPD and the RTD groups. HRQL assessed by The Medical Outcome Study 36 ‐Item Short‐form Health Survey (SF‐36) and Severe Respiratory Insufficiency (SRI); the sleep qua...
Source: The Clinical Respiratory Journal - May 27, 2020 Category: Respiratory Medicine Authors: Aycan Y üksel, Fatma Çiftçi, Aydın Çiledağ, Akın Kaya Tags: ORIGINAL ARTICLE Source Type: research

Comparative clinical study on microwave ablation combined with cisplatin plus gemcitabine or pemetrexed in treatment of advanced NSCLC
AbstractObjectiveSolving the limitations of single chemotherapy in the treatment of non ‐small cell lung cancer (NSCLC).Methods100 patients with NSCLC treated in First Hospital of Jiaxing, Zhejiang from June 2016 to June 2018 were selected and randomly divided into MPC group and MGC group, with 50 cases in each group. The patients in MPC group were treated with MWA combined with PC while patients in MGC group were given MWA combined with GC. The therapeutic effects of the two groups as well as the complications and ADRs were observed and recorded.ResultsThere was no significant difference in disease response rate (MPC gr...
Source: The Clinical Respiratory Journal - May 22, 2020 Category: Respiratory Medicine Authors: YingQing Zhang, Yan Feng, YongLei Wu, YingXin Zhou, LinLan Wang Tags: ORIGINAL ARTICLE Source Type: research

A Mortality Analysis of Septic Shock, Vasoplegic Shock, and Cryptic Shock Classified by the Third International Consensus Definitions (Sepsis ‐3)
This study aimed to compare the 28 ‐day mortality of patients with septic shock, defined by Sepsis‐3 criteria, and patients with vasoplegic or cryptic shock who are excluded from this new definition.ObjectivesThis retrospective observational study was performed using a tertiary emergency department ’s septic shock registry and investigated the records of patients managed between January 2010 and December 2015. 2,138 total patients, 1004 (47.0%) had septic shock, 476 (22.2%) had vasoplegic shock, and 655 (30.6%) had cryptic shock.ResultsThere was significant variation in 28 ‐day mortality among the three groups:...
Source: The Clinical Respiratory Journal - May 21, 2020 Category: Respiratory Medicine Authors: Won Seok Yang, Hui Dong Kang, Sang Ku Jung, You Jin Lee, Se Hyun Oh, Youn ‐Jung Kim, Chang Hwan Sohn, Won Young Kim Tags: ORIGINAL ARTICLE Source Type: research

Application of autologous SOX9+ airway basal cells in patients with bronchiectasis
ConclusionTransplantation of autologous SOX9+ BCs has positive effects and is safe for patients with bronchiectasis. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 20, 2020 Category: Respiratory Medicine Authors: Fengjun Sun, Lin Cheng, Haiqing Guo, Yufen Sun, Yu Ma, Yu Wang, Wei Feng, Qian Yuan, Xiaotian Dai Tags: ORIGINAL ARTICLE Source Type: research

Continuous positive pressure therapy usage and incident stroke in patients with obstructive sleep apnea: A nationwide population ‐ based cohort study
ConclusionsIt is possible that treatment with CPAP might be beneficial for protection against stroke, but this conclusion should be interpreted with caution. Future studies with satisfactory CPAP quality and duration are needed to validate this observation. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 18, 2020 Category: Respiratory Medicine Authors: En ‐Ting Chang, Weishan Chen, Ling‐Yi Wang, Shih‐Fen Chen, Chung‐Y Hsu, Yu‐Chih Shen Tags: ORIGINAL ARTICLE Source Type: research

Predictive value of immune ‑inflammation indices in terms of metabolic response and outcome after curative radiotherapy for non‑small cell lung cancer
ConclusionsImmunoinflammatory indices are feasible prognostic indicators for clinical use with easily accessible components. In this study we demonstrated that pretreatment PNI ≤ 45,45 was statistically significant for predicting poor treatment response. None of the indices were significantly correlated with radiation pneumonitis. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 18, 2020 Category: Respiratory Medicine Authors: E. Elif Ozkan, Z. Arda Kaymak Cerkesli, Mehmet Erdo ğan Tags: ORIGINAL ARTICLE Source Type: research

Use of the COPD Assessment Test (CAT) to screen for COPD in dairy farmers: AIRBAg study
This study assesses the value of the COPD Assessment Test (CAT) questionnaire for screening dairy farmers, who tend to be slow or reluctant to seek health care.MethodsDuring the time period 2012 ‐2017, 2089 randomly selected dairy farmers in Brittany (France) were invited to complete self‐administered questionnaires (including the CAT) and to undergo an occupational health check‐up using an electronic mini‐spirometer and conventional spirometry. Those showing symptoms suggestive of COPD and/or a ratio FEV1/FEV6
Source: The Clinical Respiratory Journal - May 9, 2020 Category: Respiratory Medicine Authors: Simon Jan, Marie ‐Astrid Metten, Anthony Chapron, Solenne Marette, Ange‐Marie Robert, Stéphanie Guillot, Carole Mailloux, Stéphane Jouneau, Jean‐François Viel, The AIRBAG research group, Jean Barakat, Anne‐Laure Barel, Henri‐Pierr Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 14, Issue 5, Page 421-421, May 2020. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 8, 2020 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Cover image
The cover image is based on the Original Article, The utility of elastography during EBUS ‐TBNA in a population with a high prevalence of anthracosis by Atefeh Abedini et al.,https://doi.org/10.1111/crj.13159https://doi.org/10.1111/crj.13159 (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 8, 2020 Category: Respiratory Medicine Authors: Atefeh Abedini, Fatemeh Razavi, Mehrdad Farahani, Marzieh Hashemi, Habib Emami, Forouzan Mohammadi, Arda Kiani Tags: COVER IMAGE Source Type: research

Prevalence of Non ‐Thyroidal Illness Syndrome in COPD Exacerbation and Effect of Hypoxaemia and Hypercapnia on Thyroid Functions
The objective of the current study is to determine the prevalence of non‐thyroidal illness syndrome among hospitalized patients due to acute exacerb ation of chronic obstructive pulmonary disease (AECOPD) and to reveal the factors affecting thyroid functions.Materials and MethodA total of 132 patients hospitalized for AECOPD were enrolled. Arterial blood gas samples at room air and venous blood samples for thyroid function tests were obtained within 24 hours following hospitalization.ResultsThe mean age was 69.3 ±9.6 years with male predominance (M/F:130/2). The prevalence of NTIS was 55%. Subgroups of NTIS cases ...
Source: The Clinical Respiratory Journal - May 4, 2020 Category: Respiratory Medicine Authors: Aziz Gumus, Song ül Ozyurt, Neslihan Ozcelik, Bilge Yılmaz Kara Tags: ORIGINAL ARTICLE Source Type: research

Diagnostic performance of 19 ‐gauge endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) in suspected lymphoma: a prospective cohort study
ConclusionDiagnostic performance of 19G EBUS ‐TBNA appears similar to standard 22G needle in detection and definitive diagnosis of lymphoma. Further invasive testing remains necessary following non‐diagnostic EBUS‐TBNA procedures. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 19, 2020 Category: Respiratory Medicine Authors: Christopher E. Lim, Daniel P. Steinfort, Louis B. Irving Tags: ORIGINAL ARTICLE Source Type: research

Survival Value of Primary Tumor Resection for Stage IV Non ‐small‐cell lung cancer: a Population Based Study of 6466 Patients
AbstractIntroductionFor stage IV non ‐small‐cell lung cancer (NSCLC) patients, surgical resection of primary tumor was rarely recommended.ObjectivesWe conducted this population based study to demonstrate the survival value of primary tumor resection (PTR) for stage IV (NSCLC).MethodsThe Surveillance, Epidemiology and End Results (SEER) database was searched for selecting stage IV NSCLC patients. The patients were matched according to age, gender, grade, primary tumor site, histopathological type, tumor size and regional lymph nodes metastasis by propensity score matching (PSM) analysis. Kaplan ‐Meier curves were pres...
Source: The Clinical Respiratory Journal - April 16, 2020 Category: Respiratory Medicine Authors: Jing Xu, Lulu Fan, Hanqing Yu, Donghui Lu, Wanren Peng, Guoping Sun Tags: ORIGINAL ARTICLE Source Type: research

Treatment of a case presenting as critical adenoviral ARDS using Cidofovir with early combinatorial prone ventilation and ECMO
AbstractHere, we report a case of adenoviral pneumonia associated with severe ARDS treated with Cidofovir, prone ventilation, and extracorporeal membrane oxygenation (ECMO). The patient responded well to therapy and recovered without further complications. Cidofovir, with early prone ventilation and ECMO support, may be a therapeutic option for patients with severe ARDS related to adenoviral pneumonia. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 16, 2020 Category: Respiratory Medicine Authors: Chao Liu, Wei ‐wei Ning, Yan‐bin Chen, Ye‐han Zhu, Yu Xia, Jian‐an Huang, Cheng Chen Tags: BRIEF REPORT Source Type: research

Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin ‐17 and prognosis
AbstractPurposeTranscription co ‐activator p300/CBP, a histone acetyltransferase, has a central role in tumors, inflammation and neurodegenerative diseases. We investigated the effect of p300/CBP and its association with various IL‐17‐related indicators and prognosis in patients with acute respiratory distress syndrome(ARDS) .Materials and MethodsWe enrolled 45 adult ARDS patients who were followed for 28 days and 22 healthy controls. The mRNA expression of p300, CBP, ROR γt and Foxp3 and the plasma levels of several cytokines were measured.ResultThe mRNA levels of p300, CBP and ROR γt, and plasma concent...
Source: The Clinical Respiratory Journal - April 16, 2020 Category: Respiratory Medicine Authors: Yan Chen, Bin Huang, Yan Zhao, Di Qi, Daoxin Wang Tags: ORIGINAL ARTICLE Source Type: research

Characteristics and survival impact of polymorphonuclear leukocyte ‐predominant malignant pleural effusions secondary to lung cancer
AbstractIntroductionIn comparison with mononuclear leukocyte (MNL) ‐predominant malignant pleural effusions (MPEs), polymorphonuclear leukocyte (PMNL)‐predominant MPEs have rarely been investigated and may be associated with a poorer prognosis.ObjectivesTo investigate the characteristics and survival impact of PMNL ‐predominant MPEs secondary to lung cancer.MethodsThis retrospective study included patients with MPE secondary to lung cancer, which were classified into the PMNL ‐ and MNL‐predominant groups according to cellular predominance in the pleural fluid. Clinical, hematological, radiological, and pleural fl...
Source: The Clinical Respiratory Journal - April 15, 2020 Category: Respiratory Medicine Authors: Jaehee Lee, Yong Hoon Lee, Hyewon Seo, Young Woo Do, Deok Heon Lee, Sang Yub Lee, Jae Kwang Lim, Seung Soo Yoo, Shin Yup Lee, Seung Ick Cha, Jae Yong Park, Chang Ho Kim Tags: ORIGINAL ARTICLE Source Type: research

“Elasto‐Lung Point”: a new tool for the sonographic confirmation of pneumothorax
ConclusionThe “elasto‐lung point” was able to confirm the diagnosis of pneumothorax in every investigated patient.USE is a simple, reproducible and inexpensive technique that can contribute to the diagnosis of pneumothorax, such as the classic “stratosphere” or “Bar Code” sign in M‐mode. No false negative cases were observed. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 14, 2020 Category: Respiratory Medicine Authors: Gian Piero Bandelli, Guido Levi, Federico Quadri, Gian Pietro Marchetti Tags: ORIGINAL ARTICLE Source Type: research

Relationship between spirometry results and colonisation of Aspergillus species in allergic asthma
ConclusionOur results showed that there is no difference in the FEV1 and forced vital capacity betweenAspergillus positive and negative patients in any asthma severity group. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 7, 2020 Category: Respiratory Medicine Authors: Mahshid Vakili, Masoud Aliyali, Vida Mortezaee, Seyed Alireza Mahdaviani, Mihan Poorabdollah, Maryam Sadat Mirenayat, Atefeh Fakharian, Maryam Hassanzad, Mahdi Abastabar, Jamshid Yazdani Charati, Iman Haghani, Mahin Tavakoli, Maedeh Maleki, D Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 14, Issue 4, Page 305-306, April 2020. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 1, 2020 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Is Onodera ’s prognostic nutritional index (OPNI) a prognostic factor in small cell lung cancer (SCLC)?
This study retrospectively examined 109 patients diagnosed with SCLC between January 2008 and October 2018 in our hospital. Patients were divided into two groups according to the median of OPNI values.ResultsA significant difference was observed between the groups in terms of neutrophil percentage, lymphocyte count, lymphocyte percentage, C ‐reactive protein (CRP), albumin, lactat dehidrogenase (LDH) and neutrophil to lymphocyte ratio (NLR) (P 
Source: The Clinical Respiratory Journal - March 31, 2020 Category: Respiratory Medicine Authors: Derya Yenibertiz, Berna Akinci Ozyurek, Yurdanur Erdogan Tags: ORIGINAL ARTICLE Source Type: research

Relationship between spirometry results and colonization of Aspergillus species in allergic asthma
ConclusionOur results showed that there is no difference in the FEV1 and forced vital capacity betweenAspergillus positive and negative patients in any asthma severity group. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 27, 2020 Category: Respiratory Medicine Authors: Mahshid Vakili, Masoud Aliyali, Vida Mortezaee, Seyed Alireza Mahdaviani, Mihan Poorabdollah, Maryam Sadat Mirenayat, Atefeh Fakharian, Maryam Hassanzad, Mahdi Abastabar, Jamshid Yazdani Charati, Iman Haghani, Mahin Tavakoli, Maedeh Maleki, Darius Armstr Tags: ORIGINAL ARTICLE Source Type: research

Metabolic activity of primary tumour on PET/CT has a relationship with survival in stages I ‐III small‐cell lung carcinoma
ConclusionPretreatment SUVmax‐PT (median cut‐off 11.6) may have a prognostic value of OS and PFS in patients with TNM staged I‐III SCLC. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 27, 2020 Category: Respiratory Medicine Authors: Özer Özdemir, Özgür Batum, Sinem Ermin, Nimet Aksel, Berna Kömürcüoğlu, Aydan Mertoğlu, Sami Deniz, Günseli Balcı, Hakan Koparal, Engin Özbilek, Ufuk Yılmaz Tags: ORIGINAL ARTICLE Source Type: research

Adherence to COPD free triple inhaled therapy in the real ‐world: a primary care based study
ConclusionsThe 85% of enrolled patients showed poor adherence to free triple inhaled therapy. Co ‐morbidities, such as heart failure (OR 1.78, 95%CI 1.19‐2.75), depression (OR 1.41, 95%CI 1.06‐1.88), and peripheral vascular disease (OR 1.32, 95%CI 1.01‐1.74) were associated with poor adherence. Former (OR 0.52, 95%CI 0.34‐0.78) or current smokers (OR 0.61, 95%CI 0.41‐0.93) and patie nts with more severe airways obstruction or history of severe exacerbations (OR 0.64, 95%CI 0.52‐0.79) were less likely to exhibit poor adherence. Real‐world adherence to triple inhaled therapy with different inhalers is general...
Source: The Clinical Respiratory Journal - March 26, 2020 Category: Respiratory Medicine Authors: Alberto Zucchelli, Davide L Vetrano, Elisa Bianchini, Francesco Paolo Lombardo, Alessio Piraino, Marco Zibellini, Alberto Ricci, Alessandra Marengoni, Francesco Lapi, Claudio Cricelli Tags: ORIGINAL ARTICLE Source Type: research

What is the emergency application differences concerning diseases pertinent to the chest between Turkish citizens and Syrian refugees ?: A cross ‐sectional study
ConclusionThere are differences in the disease patterns of Syrian refugees and Turkish citizens applying to the emergency department. This may be explained by the difficulty in communication which, to our opinion, may be reversed as language barriers are overcome and adaptation to the society is completed over time. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 23, 2020 Category: Respiratory Medicine Authors: Ozlem Sengoren Dikis, Hakan Demirci, Bi şar Sezgin, Miktat Arif Haberal, Erkan Akar, Halil Kaya Tags: ORIGINAL ARTICLE Source Type: research

Anti ‐tumour effects of Keratin 6A in lung adenocarcinoma
ConclusionsKRT6A protein inhibits the proliferation, migration and invasion abilities of lung adenocarcinoma cells, and high expression of KRT6A protein is a predictor of good prognosis in patients with lung adenocarcinoma. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 21, 2020 Category: Respiratory Medicine Authors: Jian Xiao, Xiao Kuang, Longxia Dai, Lihai Zhang, Bixiu He Tags: ORIGINAL ARTICLE Source Type: research

Analysis of clinical features and prognostic factors of lung cancer patients: A population ‐based cohort study
AbstractObjectivesThis paper analyzes clinical features of lung cancer patients and discusses factors influencing lung cancer occurrence and prognosis.MethodsPatients diagnosed with lung cancer from 1975 to 2016 are analyzed based on SEER database. The samples are divided into groups according to the number of positive lymph nodes of LN>3 and LN ≤3. Univariate and multivariate Cox risk models are performed. After balancing the clinicopathological features of the two groups with the propensity score matching (PSM) method, the survival rates of the two groups are compared.ResultsA total of 30,864 patients are included ...
Source: The Clinical Respiratory Journal - March 20, 2020 Category: Respiratory Medicine Authors: Yuan Gao, Xinjia Zhou Tags: ORIGINAL ARTICLE Source Type: research

Contrasting characters of quick methods to measure respiratory rate in a clinical setting
ConclusionCompared to the gold standard, RTM tends to underestimate, while 15secRR tends to overestimate the respiratory rate. Therefore, health care professionals should be aware of this methodological tendency to assess vital signs properly. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 19, 2020 Category: Respiratory Medicine Authors: Atsushi Takayama, Takahiko Nagamine, Kazuhiko Kotani Tags: ORIGINAL ARTICLE Source Type: research

Withdrawn: “Hypercapnia Attenuates Ventilator‐induced Lung Injury through Vagus Nerve Activation” by Guang Li, Jiao Liu, Chen‐Liang Zhou, Wen‐Fang Xia and Di Zhang
Abstracthttps://onlinelibrary.wiley.com/doi/abs/10.1111/crj.13156The above article fromThe Clinical Respiratory Journal, published online on 4 Feburary 2020 in Wiley Online Library (wileyonlinelibrary.com) has been withdrawn by agreement between the authors, the journal Editor ‐in‐Chief and John Wiley& Sons Ltd. The withdrawal has been agreed due to an inadvertent duplicate submission. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 18, 2020 Category: Respiratory Medicine Tags: WITHDRAWN Source Type: research

Anti ‐tumor effects of Keratin 6A in lung adenocarcinoma
ConclusionsKRT6A protein inhibits the proliferation, migration and invasion abilities of lung adenocarcinoma cells, and high expression of KRT6A protein is a predictor of good prognosis in patients with lung adenocarcinoma. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 16, 2020 Category: Respiratory Medicine Authors: Jian Xiao, Xiao Kuang, Longxia Dai, Lihai Zhang, Bixiu He Tags: ORIGINAL ARTICLE Source Type: research

Feasibility study of ultrasound video bronchoscopy for sampling endobronchial lesions
ConclusionBoth forceps biopsy and needle aspiration are feasible using a Fujifilm EB ‐530US EBUS video bronchoscope. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 16, 2020 Category: Respiratory Medicine Authors: Masahide Oki, Hideo Saka, Yoshihito Kogure, Saori Oka, Masashi Nakahata, Fumie Shigematsu, Akane Ishida, Chiyoe Kitagawa Tags: ORIGINAL ARTICLE Source Type: research

The effectiveness, safety and compliance of Zheng ’s supine rehabilitation exercise as a rehabilitation programme among elderly patients with AECOPD
AbstractPurposeWe investigated the effectiveness, safety and compliance of Zheng ’s Supine Rehabilitation Exercise (ZSRE) as a rehabilitation programme among elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Patients and methodsAbout 82 elderly patients with AECOPD were divided into a rehabilitation group and control group on their admission day, and both groups received routine medical treatment. Patients in the rehabilitation group started ZSRE on the second day of admission and continued until 8  weeks after discharge.ResultsAt the 9th week after discharge, the COPD As...
Source: The Clinical Respiratory Journal - March 16, 2020 Category: Respiratory Medicine Authors: Haonan Lu, Ni Liu, Jie Ying Hu, Xinni Wang, Youxia Li, Mali Song, Li Hong Zhong, Wei He, RongChang Chen, Zeguang Zheng Tags: ORIGINAL ARTICLE Source Type: research

Treatment outcomes in oligometastatic non ‐small‐cell lung cancer: A single‐centre experience
ConclusionIn well ‐selected NSCLC patients with limited metastasis, survival rates can reach up to 3 years, even in a geriatric population. Clinical N staging and co‐morbidity are important prognostic factors. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 16, 2020 Category: Respiratory Medicine Authors: P ınar Akın Kabalak, Derya Kızılgöz, Ülkü Yılmaz, Tuba İnal Cengiz, Evrim Tunç, Şebnem Yaman, Erkmen Gülhan Tags: ORIGINAL ARTICLE Source Type: research

Identification of a novel cystic fibrosis mutation in three patients of South Asian descent
ConclusionOur work highlights the value of extended or targeted genotyping in selected populations. It also demonstrates the benefit of routine collaboration between national registries. This will promote the identification of novel mutations; leading to greater understanding of genotype ‐phenotype associations, improved individual prognostication and ultimately the improved availability of novel precision therapies. This collaboration is essential if we are to achieve health equality for people with CF living in resource‐limited settings. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 16, 2020 Category: Respiratory Medicine Authors: Aisling Semple, Tara Clark, Nicholas M. Allen, Thanuja Krishnananthan, Chinedu Nwokoro, Emmanuelle Girodon, Michele Porzio, Mary Herzig Tags: BRIEF REPORT Source Type: research

Characterization and management of elderly and very elderly patients with non ‐small cell lung cancer
AbstractObjectivesDespite non –small cell lung cancer (NSCLC) high prevalence and increasing incidence, evidence specific to the elderly and very elderly is sparse. To retrospectively compare characterization and approach of NSCLC patients (pts) aged 70‐79 and ≥ 80 years.MethodsWe performed a retrospective analysis of 297 adult NSCLC pts who registered and initiated NSCLC management in our Pulmonology Oncology Unit from January, 2013 to December, 2016 corresponding to 38.2% of all NSCLC patients (n=778). Demographic data and lung cancer management were analysed.ResultsPts were categorized as elderly (n=211, 71.0...
Source: The Clinical Respiratory Journal - March 16, 2020 Category: Respiratory Medicine Authors: Vera Cl érigo, Direndra Hasmucrai, Encarnação Teixeira, Paula Alves, Ana Sofia Vilariça, Renato Sotto‐Mayor Tags: BRIEF REPORT Source Type: research

Is Onodera's Prognost ıc Nutrıtıonal Index (OPNI) a prognostıc factor ın Small Cell Lung Cancer (SCLC)?
This study retrospectively examined 109 patients diagnosed with SCLC between January 2008 and October 2018 in our hospital. Patients were divided into two group according to the median of OPNI values.ResultsA significant difference was observed between the groups in terms of neutrophil percentage, lymphocyte count, lymphocyte percentage, C ‐reactive protein (CRP), albumin, lactat dehidrogenase (LDH) and neutrophil to lymphocyte ratio (NLR) (p
Source: The Clinical Respiratory Journal - March 16, 2020 Category: Respiratory Medicine Authors: Derya Yenibertiz, Berna Akinci Ozyurek, Yurdanur Erdogan Tags: ORIGINAL ARTICLE Source Type: research

Metabolic activity of primary tumor on pet/ct has a relationship with survival in stage I ‐III small‐cell lung carcinoma
ConclusionPre ‐treatment SUVmax‐PT (median cut‐off 11.6) may have a prognostic value of OS and PFS in patients with TNM staged I‐III SCLC. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 16, 2020 Category: Respiratory Medicine Authors: Özer Özdemir, Özgür Batum, Sinem Ermin, Nimet Aksel, Berna Kömürcüoğlu, Aydan Mertoğlu, Sami Deniz, Günseli Balci, Hakan Koparal, Engin Özbilek, Ufuk Yilmaz Tags: ORIGINAL ARTICLE Source Type: research

Validation of the Finnish Severe Respiratory Insufficiency Questionnaire
ConclusionsThe Finnish SRI proved valid, reliable, and reproducible. Its psychometric properties were good and similar to those of the original questionnaire and of other validation studies. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 11, 2020 Category: Respiratory Medicine Authors: Petra Kotanen, Annette Kainu, Pirkko Brander, Paula Bergman, Anu Lehtom äki, Hanna‐Riikka Kreivi Tags: ORIGINAL ARTICLE Source Type: research

Pulsed echinocandin therapy in azole intolerant or multiresistant chronic pulmonary aspergillosis: A retrospective review at a UK tertiary centre
ConclusionsWith pulsed echinocandin therapy, azole ‐intolerant or pan‐resistant CPA patients have similar mortality rates to azole‐naïve CPA patients. Pulsed echinocandin therapy may present a strategy to stabilize CPA in patients with pan resistance or intolerance to, azole therapy. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 7, 2020 Category: Respiratory Medicine Authors: William Osborne, Michelle Fernandes, Sophie Brooks, Emily Grist, Charlie Sayer, David M. Hansell, Robert Wilson, Anand Shah, Michael R. Loebinger Tags: ORIGINAL ARTICLE Source Type: research

The prognostic value of the serum albumin level for long ‐term prognosis in patients with acute pulmonary embolism
AbstractIntroduction and objectivesThe aim of this study was to investigate the association of serum albumin (SA) level with long ‐term prognosis in patients with acute pulmonary embolism (PE).Materials and methodsWe retrospectively enrolled 269 patients with acute PE. The SA level was obtained within 12 ‐24 hours following admission. The primary endpoints were the incidence of short‐ and long‐term mortality in acute PE patients. The mean duration of the study follow‐up was 21 ± 19 months.ResultsDuring the follow ‐up period, short‐ and long‐term mortality rates were higher in patients who h...
Source: The Clinical Respiratory Journal - March 7, 2020 Category: Respiratory Medicine Authors: Veysel Ozan Tan ık, Tufan Çınar, Yavuz Karabağ, Barış Şimşek, Cengiz Burak, Metin Çağdaş, İbrahim Rencüzoğulları Tags: ORIGINAL ARTICLE Source Type: research

Thiol ‐disulfide as a novel indicator of obstructive sleep apnea
AbstractIntroductionOSA is an oxidative stress disease, which has been considered to be a notable risk and associated with increased cardiovascular morbidity and mortality. Thiol ‐disulfide homeostasis is as a novel indicator of oxidative stress.ObjectivesWe aimed to evaluate thiol ‐disulfide homeostasis in a large patient population with obstructive sleep apnea (OSA).MethodsA total of 230 with OSA and 40 healthy controls were included in the study. Inclusion criteria for OSA patients are having apnea ‐hypopnea index of ≥ 5 /per hour, being more than 18 years of age and having no previous treatment for OSA. Thiol...
Source: The Clinical Respiratory Journal - March 7, 2020 Category: Respiratory Medicine Authors: Emine Arg üder, Ebru Şengül Parlak, Hatice Kılıç, Habibe Hezer, Salim Neşelioğlu, H.Canan Hasanoğlu, Gökhan Yalçıner, M. Ali Babademez, Özcan Erel Tags: ORIGINAL ARTICLE Source Type: research

The relationship between obstructive sleep apnea syndrome and obesity: A new perspective on the pathogenesis in terms of organ crosstalk
ConclusionObesity and OSAS adversely affect many organs and systems. Besides the factors affecting the diagnosis of the OSAS ‐obesity relationship, mutual organ interactions among the respiratory system, adipose tissue and intestines should not be ignored for prevention and treatment of OSAS and obesity. Comprehensive clinical trials addressing the efficacy and efficiency of current or potential treatments on therapeuti c applications in the OSAS‐obesity relationship are needed. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 6, 2020 Category: Respiratory Medicine Authors: Nuray Kuvat, Hakan Tanriverdi, Ferah Armutcu Tags: REVIEW ARTICLE Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 14, Issue 3, Page 181-182, March 2020. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 4, 2020 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

A Survey of Precision Diagnosis and Management Capacity of Pulmonary Embolism in 90 Hospitals of China
ConclusionThe hospitals are capable for standardized diagnosis and management PE, while the capability of precise stratification, coagulation function tests, thrombophilia screening and pharmacogenomics requires further improvement. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 4, 2020 Category: Respiratory Medicine Authors: Dingyi Wang, Xiang Shao, Jieping Lei, Zhenguo Zhai Tags: ORIGINAL ARTICLE Source Type: research

Association between risk stratification for pulmonary embolism and deep vein thrombosis of lower extremities
AbstractBackgroundThe association of clinical risk factors, in particular deep vein thrombosis (DVT), with risk stratification for pulmonary embolism (PE) remains to be identified. We therefore aimed to establish the relationship between risk stratification of PE patients and DVT of lower extremities.MethodsIn this retrospective study, 93 out of 485 PE patients with uncompleted clinical data were excluded, resulting in 392 patients included for analysis. Based on the ESC criteria, 24, 171, and 197 patients were categorized into high (6.1%), intermediate (43.6%), and low risk (50.3%) subgroups, respectively.ResultsDVT was d...
Source: The Clinical Respiratory Journal - March 4, 2020 Category: Respiratory Medicine Authors: Xiao ‐Hui Wang, Long‐Biao Cui, Yuliang Liu, Xiaoli Han, Jing Chi, Bijun Yang, Hong Chen Tags: ORIGINAL ARTICLE Source Type: research

Sex ‐related difference in the prognostic value of syncope for 30‐day mortality among hospitalized pulmonary embolism patients
ConclusionAlthough syncope is associated with other predictors of higher early mortality in both male and female PE patients, only in women it is a significant predictor of 30 ‐day mortality. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 4, 2020 Category: Respiratory Medicine Authors: Boris Dzudovic, Bojana Subotic, Natasa Novicic, Jovan Matijasevic, Jadranka Trobok, Milica Miric, Sonja Salinger ‐Martinovic, Dragana Stanojevic, Maja Nikolic, Vladimir Miloradovic, Natasa Markovic Nikolic, Milica Dekleva, Danijela Lepojevic Tags: ORIGINAL ARTICLE Source Type: research

Computed tomography ‐guided biopsy for sub‐centimetre lung nodules: Technical success and diagnostic accuracy
ConclusionsCT ‐guided biopsy is a safe and highly accurate diagnostic method for SCLNs. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 1, 2020 Category: Respiratory Medicine Authors: Yu Li, Tao Wang, Yu ‐Fei Fu, Yi‐Bing Shi, Jing‐Ya Wang Tags: ORIGINAL ARTICLE Source Type: research