Factors contributing to COPD hospitalisations from 2010 to 2015: Variation among rural and metropolitan Australians
ConclusionThis investigation highlights many rural and regional areas have much lower COPD hospitalisation rates than metropolitan areas. Between males and females, there are heterogenetic factors that contribute to the significant variation associated with COPD hospitalisation in metropolitan and rural areas, such as rural land use among rural males. This indicates that risk factor assessments, beyond smoking alone, need to be individualised and prioritised in practice to optimise care. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 18, 2019 Category: Respiratory Medicine Authors: Daniel R. Terry, Hoang Nguyen, Jeong ‐Ah Kim, Md Rafiqul Islam Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 13, Issue 3, Page 129-130, March 2019. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 6, 2019 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Novel insights into the systemic treatment of lung cancer malignant pleural effusion
AbstractLung cancer is the most common fatal malignancy worldwide. Approximately 75% of non ‐small‐cell lung cancer (NSCLC) patients are diagnosed at an advanced or a metastatic stage. Since 2007, NSCLC patients with malignant pleural effusion (MPE) are staged as M1 disease. During the last decades, chemotherapeutic agents failed to offer a significant improvement of survival in patien ts with metastatic disease. The current review aims to summarize the actual situation of the recently developed therapies in patients with lung cancer and MPE. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 6, 2019 Category: Respiratory Medicine Authors: Claire Tissot, Pierre Gay, Cl ément Brun, Marios E. Froudarakis Tags: SERIES ON PLEURAL DISEASES Source Type: research

Diagnosis and management of asthma, COPD and asthma ‐COPD overlap among primary care physicians and respiratory/allergy specialists: a global survey
ConclusionWhile most PCPs and respiratory/allergy specialists can reach a working diagnosis of ACO, there remains uncertainty around which diagnostic features are most important and what constitutes optimal management. It is imperative that clinical studies including patients with ACO are initiated, allowing the generation of evidence ‐based management strategies.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 2, 2019 Category: Respiratory Medicine Authors: Christine Jenkins, J. Mark FitzGerald, Fernando J. Martinez, Dirkje S. Postma, Stephen Rennard, Thys van der Molen, Asparuh Gardev, Eduardo Genofre, Peter Calverley Tags: Original Article Source Type: research

Repetitive saliva swallowing test and water swallowing test may identify a COPD phenotype at high risk of exacerbation
AbstractIntroductionPatients with chronic obstructive pulmonary disease (COPD) are known to present with dysphagia from an early stage. Dysphagia leads to swallowing ‐related complications, in turn leading to COPD exacerbation. Dysphagia screening is recommended; however little is known of its utility in detecting a COPD phenotype at risk for exacerbation. The simple swallowing provocation test (SSPT), considered to be a standard screening test, requires speci fic equipment, physician skill, and patient discomfort.ObjectivesThe aim of this study was to find an easier and less invasive measure to screen for dysphagia in p...
Source: The Clinical Respiratory Journal - March 1, 2019 Category: Respiratory Medicine Authors: Yuki Yoshimatsu, Kazunori Tobino, Takuto Sueyasu, Saori Nishizawa, Yuki Goto, Kojin Murakami, Miyuki Munechika, Kohei Yoshimine, Hiroyuki Miyajima Tags: Original Article Source Type: research

Clinical and radiological manifestations of lipoid pneumonia according to etiology: squalene, omega ‐3‐acid ethyl esters, and idiopathic
ConclusionsIn comparison with the exogenous group, the idiopathic group demonstrated BAL lymphocytosis, higher rates of recurrence and BAF, and a higher rate of crazy ‐paving pattern. Compared with the O‐3‐AEE group, the squlaene group showed a higher percentage of BAL neutrophils and predominant RML involvement.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 1, 2019 Category: Respiratory Medicine Authors: Seung ‐Ick Cha, Sun Ha Choi, Hyun Jung Kim, Yeon Jae Kim, Jae‐Kwang Lim, Seung‐Soo Yoo, Shin‐Yup Lee, Jaehee Lee, Chang‐Ho Kim, Jae‐Yong Park Tags: Original Article Source Type: research

Factors contributing to COPD hospitalisations from 2010 –2015: Variation among rural and metropolitan Australians
ConclusionThis investigation highlights many rural and regional areas have much lower COPD hospitalisation rates than metropolitan areas. Between males and females, there are heterogenetic factors that contribute to the significant variation associated with COPD hospitalisation in metropolitan and rural areas, such as rural land use among rural males. This indicates that risk factor assessments, beyond smoking alone, need to be individualised and prioritised in practice to optimise care.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 28, 2019 Category: Respiratory Medicine Authors: Daniel Terry, Hoang Nguyen, Jeong ‐Ah Kim, Md Rafiqul Islam Tags: Original Article Source Type: research

Screening instrument to identify skin prick test negative patients with asthma and/or rhinitis
ConclusionsWe designed a highly specific 13 ‐item instrument for identifying SPT‐negative patients. It may be used in middle income countries where allergy testing is expensive, not reimbursed or few allergy clinics are available. We think that our idea is interesting, that needs further research.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 27, 2019 Category: Respiratory Medicine Authors: Ebru Celebioglu, Ahmet Ugur Demir, Gul Karakaya, Ali Fuat Kalyoncu Tags: Original Article Source Type: research

The impact of therapy on the risk of asthma in type 2 diabetes
ConclusionsT2DM may have a protective effect against asthma development. Insulin use was associated with an increased risk of asthma, whilst metformin and sulphonylureas reduced the risk in those with T2DM.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 27, 2019 Category: Respiratory Medicine Authors: Louise H. Rayner, Andrew P Mcgovern, Julian Sherlock, Piers Gatenby, Ana Correa, Ben Creagh ‐Brown, Simon De Lusignan Tags: Original Article Source Type: research

Intrapleural Immunotherapy: An Update on Emerging Treatment Strategies for Pleural Malignancy
ConclusionIntrapleural immunotherapies for pleural malignancy have demonstrated promise with regards to generating durable tumor ‐specific immune responses with possible clinical benefits which merit further investigation as part of multimodal chemo‐ and immunotherapeutic regimens.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 27, 2019 Category: Respiratory Medicine Authors: Vivek Murthy, Daniel Katzman, Daniel H. Sterman Tags: Series on Pleural Diseases Source Type: research

Comparing the Effects and Compliance between Volume Assured and Pressure Support Non ‐invasive Ventilation in Patients with Chronic Respiratory Failure
ConclusionsThe evidence shows there is no significant difference in clinical outcomes when comparing AVAPS and PS ‐NIV used for Chronic Respiratory Failure patients (CRF).This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 25, 2019 Category: Respiratory Medicine Authors: Xu An Huang, Yan Ping Du, Liu ‐Xia Li, Fang Fang Wu, Shao Qing Hong, Fang Xuan Tang, Zhang Qiang Ye Tags: Original Article Source Type: research

The effect of atrial fibrillation intervention on nocturnal respiratory events in elderly patients with persistent AF
ConclusionsSDB is highly prevalent in patients with persistent AF. Restoration of sinus rhythm, and the associated long ‐term recovery of haemodynamics, is associated with a significant reduction in AHI. This implicates reversal of fluid shift from the lower limbs to the neck region, a key mechanism in the pathogenesis of SDB.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 21, 2019 Category: Respiratory Medicine Authors: W Eysenck, N Sulke, N Freemantle, N R Patel, S S Furniss, R A Veasey Tags: Original Article Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 13, Issue 2, Page 71-72, February 2019. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 21, 2019 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Most Impactful Predictors for Hyperoxaemia in Exacerbation of Chronic Obstructive Pulmonary Disease Managed by Emergency Medical Services And Emergency Department
We reported adjusted odds ratios (AORs), 95% CIs and p values. We selected output factors using AOR ≥ 2.0 and ≥ 2.5 for modifiable and non‐ modifiable factors respectively. These selected factors were fed into a final model with eventual factors selected based on: threshold AORs as stated above and/or 95% CIs including these AORs.Results326 patients were analysed; 60.7% had hyperoxemia. We found three eventual modifiable factors; first ED SpO2> 95% [AOR 2.62 (95% CIs: 1.61 – 4.33); p
Source: The Clinical Respiratory Journal - February 19, 2019 Category: Respiratory Medicine Authors: Beng Leong Lim, Si Oon Cheah, Hsin Kai Goh, Francis Chun Yue Lee, Yih Yng Ng, Wen Jia Guo, Marcus Eng Hock Ong Tags: Original Article Source Type: research

Higher serum levels of systemic inflammatory markers are linked to greater inspiratory muscle dysfunction in copd
AbstractBackgroundCOPD is associated with an inflammatory response that becomes more pronounced in acute exacerbations. Considerable attention has recently focused on the value of several inflammatory mediators in predicting worsening of COPD ‐related symptoms. Whereas respiratory muscle dysfunction is also widely present in this population, little is known about how systemic inflammation relates to inspiratory muscle dysfunction in COPD.Methods53 males with mild ‐to‐very severe airflow obstruction underwent blood sampling for 23 inflammatory markers including acute‐phase proteins, cytokines, and adipokines. Inspir...
Source: The Clinical Respiratory Journal - February 18, 2019 Category: Respiratory Medicine Authors: Magno F. Formiga, Isabel Vital, Gisel Urdaneta, Brett Masters, Julio Herrera, Michael A. Campos, Lawrence P. Cahalin Tags: Original Article Source Type: research

Performance of new spirometry reference values in preoperative assessment of lung function
ConclusionAllegedly lung ‐healthy current smokers showed a higher proportion of preoperatively reduced lung function when z‐scores were used, especially in elderly subjects.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 8, 2019 Category: Respiratory Medicine Authors: Barbara Vogt, Victoria Hennig, Kathinka Deu ß, Lorenz Balke, Norbert Weiler, Inéz Frerichs Tags: Original Article Source Type: research

Novel insights in the systemic treatment of lung cancer malignant pleural effusion
This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 8, 2019 Category: Respiratory Medicine Authors: Claire Tissot, Pierre Gay, Clement Brun, Marios E. Froudarakis Tags: Series on Pleural Diseases Source Type: research

Cardiac output measurement during exercise in COPD: A comparison of dye dilution and impedance cardiography
AbstractIntroduction. Impedance cardiography (IC) derived from morphological analysis of the thoracic impedance signal is now commonly used for non ‐invasive assessment of cardiac output (CO) at rest and during exercise. However, in COPD, conflicting findings put its accuracy into question. Objectives. We therefore compared concurrent CO measurements captured by IC (PhysioFlow™: COIC) and by the indocyanine green dye dilution method (CODD) in patients with COPD. Methods. Fifty paired CO measurements were concurrently obtained using the two methods from 10 patients (FEV1:50.5 ±17.5%predicted) at rest and duri...
Source: The Clinical Respiratory Journal - February 5, 2019 Category: Respiratory Medicine Authors: Zafeiris Louvaris, Stavroula Spetsioti, Vasileios Andrianopoulos, Nikolaos Chynkiamis, Helmut Habazettl, Harrieth Wagner, Spyros Zakynthinos, Peter D. Wagner, Ioannis Vogiatzis Tags: Original Article Source Type: research

Quantification of critical care medicine: an ICU survey
ConclusionsQuantitative description of ICU activities indicates that the majority of the ICU daily practice relies on medical and respiratory interventions, which may explain why PCCM remains popular.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 5, 2019 Category: Respiratory Medicine Authors: Yashaswini Yeragunta, Stefan W. Leichtle, Renli Qiao Tags: Original Article Source Type: research

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as haematological indices of inflammatory response in ceramic workers ’ silicosis
AbstractIntroductionOccupational exposure to crystalline silica over time may result in silicosis: a fatal, irreversible occupational disease leading to lung function impairment. A complex inflammatory process, excessive accumulation of mesenchymal cells and collagen production are the primary mechanisms underlying silicosis. Neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have emerged as representative indices of systemic inflammation.ObjectivesThe purpose of the present study was to investigate the relationship between NLR, PLR and silicosis.MethodsWe retrospectively analysed the demograph...
Source: The Clinical Respiratory Journal - February 3, 2019 Category: Respiratory Medicine Authors: Mevl üt Karataş, Meşide Gündüzöz, Türkan Nadir Öziş, Osman Gökhan Özakıncı, Dilek Ergün Tags: ORIGINAL ARTICLE Source Type: research

The predictive value of plasma osmolality for in ‐hospital mortality in patients with acute pulmonary embolism
AbstractIntroduction and ObjectivesPrior studies demonstrated that plasma osmolality may have a predictive value for in ‐hospital mortality in patients with heart failure and acute coronary syndrome. In addition, plasma glucose and blood urea nitrogen (BUN) levels, the components of plasma osmolality, have been shown to be an important contributor for in‐hospital mortality in acute pulmonary embolism (APE) patien ts. Hence, the objective of the current study is to evaluate the effect of plasma osmolality upon admission with in‐hospital mortality in patients with APE.MethodsA total of 245 consecutive intermediate or h...
Source: The Clinical Respiratory Journal - February 3, 2019 Category: Respiratory Medicine Authors: Ahmet Öz, Tufan Çınar, Mert İlker Hayıroğlu, Şahin Avşar, Muhammed Keskin, Ahmet Lütfüllah Orhan Tags: Original Article Source Type: research

The role of echocardiographic parameters in predicting survival of patients with lung diseases referred for lung transplantation
ConclusionLV echocardiographic parameters (LVESD or LVEDD) are useful in predicting survival in patients with end ‐stage lung diseases, mainly in IPF patients awaiting LT. Other parameters (RV/LV ‐ 4CH and RVOT‐PLAX dilatation) may also influence survival.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 31, 2019 Category: Respiratory Medicine Authors: Jolanta Nowak, Bartosz Hudzik, Jacek T. Niedziela, Piotr Rozentryt, Marek Ochman, Piotr Przyby łowski, Marian Zembala, Mariusz Gąsior Tags: Original Article Source Type: research

Small cell lung cancer in the young: Characteristics, diagnosis and outcome data
AbstractBackgroundPatients with small cell lung cancer (SCLC) younger than 40  years are limited in number. Our research aimed to assess the characteristics, diagnosis and outcomes of this patient population.MethodsRecords of patients under the age of 40 with SCLC at the Chinese Academy of Medical Sciences between January 2006 and December 2015 were reviewed and evaluated.ResultsOne hundred and three patients (67.0% limited stage, 33.0% extensive stage) were included, along with 54 (52.4%) never ‐smokers. The median diagnostic interval and the median survival time (MST) were 51.0 days and 24.0 months, resp...
Source: The Clinical Respiratory Journal - January 28, 2019 Category: Respiratory Medicine Authors: Shiyu Jiang, Xuezhi Hao, Junling Li, Xingsheng Hu, Zefen Xiao, Hongyu Wang, Yan Wang, Yan Sun, Yuankai Shi Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 13, Issue 1, Page 1-2, January 2019. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 27, 2019 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Subglottic perioperative airway —tube inflation via randomized evaluation with variable syringe size (Spair‐Tire) study
ConclusionAlthough both 5 ‐ and 10‐mL syringes resulted in elevated cuff pressures after intubation, 5‐mL syringes resulted in a lower degree of elevation. Use of a 5‐mL syringe should be considered when inflating the endotracheal cuff to possibly reduce patient harm secondary to elevated cuff pressures. Further stud ies assessing smaller syringe sizes to reduce cuff pressures are warranted. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 27, 2019 Category: Respiratory Medicine Authors: George W. Williams, Carlos A. Artime, Omar L. Mancillas, Tariq A. Syed, Tyrone Burnett, Russell Graham, Jason Tam, Carin A. Hagberg Tags: ORIGINAL ARTICLE Source Type: research

CD146 ‐mediated acquisition of stemness phenotype enhances tumour invasion and metastasis after EGFR‐TKI resistance in lung cancer
ConclusionsCD146 molecule contributes to the stemness phenotype and migration in EGFR ‐TKI‐resistant cells. CD146 might be a potential therapeutic target for EGFR‐TKI‐resistant lung cancer or metastasis prevention. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 27, 2019 Category: Respiratory Medicine Authors: Fan Zhang, Jia Wang, Xiaobo Wang, Nan Wei, Haiyang Liu, Xiaoju Zhang Tags: ORIGINAL ARTICLE Source Type: research

The prognostic role of Gender ‐Age‐Physiology system in idiopathic pulmonary fibrosis patients treated with pirfenidone
Conclusion68 IPF patients were enrolled in the study. The median follow ‐up was 2.4 years (range 0.1‐7.4 years). A total of 22 deaths as first event (32%) and of 10 lung transplantation (15%) were recorded. The cumulative incidence of mortality at 1, 2, and 3 years was 10.4%, 22.4%, and 38.4%, respectively. The differences between the predicted and observed mortalit y were not significant for the GAP index while the observed mortality become comparable to that predicted by the GAP calculator only in the third year of follow up. The C‐index for the GAP index was 0.74 (95% CI 0.57‐0.93) while the C‐statistic value ...
Source: The Clinical Respiratory Journal - January 23, 2019 Category: Respiratory Medicine Authors: Sergio Harari, Antonella Caminati, Marco Confalonieri, Venerino Poletti, Carlo Vancheri, Alberto Pesci, Rogliani Paola, Fabrizio Luppi, Carlo Agostini, Paola Rottoli, Alessandro Sanduzzi Zamparelli, Alfredo Sebastiani, Rossana Della Porta, Fr Tags: Original Article Source Type: research

Characteristics of Cardiopulmonary Exercise Testing of Patients with Borderline Mean Pulmonary Artery Pressure
ConclusionsPatients with boPAP have a greater prevalence of exercise intolerance, a trend of impaired oxygen pulse and submaximal exercise tolerance.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 22, 2019 Category: Respiratory Medicine Authors: Rong Jiang, Hui Liu, Bigyan Pudasaini, Rui Zhang, Jian ‐Lin Xu, Lan Wang, Qin‐Hua Zhao, Ping Yuan, Jian Guo, Jing He, Su‐Gang Gong, Cheng Wu, Wen‐Hui Wu, Ci‐Jun Luo, Hong‐Ling Qiu, Zhi‐Cheng Jing, Jin‐Ming Liu Tags: Original Article Source Type: research

Disseminated herpes zoster following treatment with benralizumab
ConclusionClinical trials have reported an association of mepolizumab, another anti ‐IL‐5 monoclonal antibody with herpes zoster. This report of herpes zoster following initiation of benralizumab might suggest a possibility of a class effect of anti‐IL‐5 monoclonal antibody.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 21, 2019 Category: Respiratory Medicine Authors: Ajay Kumar Mishra, Kamal Kant Sahu, James Atem Tags: Brief Report Source Type: research

Neutrophil ‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as hematologic indices of inflammatory response in ceramic workers’ silicosis
AbstractIntroductionOccupational exposure to crystalline silica over time may result with silicosis: a fatal, irreversible occupational disease leading to lung function impairment. A complex inflammatory process, excessive accumulation of mesenchymal cells collagen production are the primary mechanisms underlying silicosis. Neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have emerged as representative indices of systemic inflammation.ObjectivesThe purpose of the present study was to investigate the relationship between NLR, PLR and silicosis.MethodsWe retrospectively analyzed demographic and...
Source: The Clinical Respiratory Journal - January 21, 2019 Category: Respiratory Medicine Authors: Mevl üt Karataş, Meşide Gündüzöz, Türkan Nadir Öziş, Osman Gökhan Özakıncı, Dilek Ergun Tags: Original Article Source Type: research

Invasive Pulmonary Aspergillosis in Patients with Influenza Infection: A Retrospective Study and Review of the Literature
AbstractIntroductionThere has been a rapid increase in the number of influenza and invasive pulmonary aspergillosis (IPA) co ‐infection.ObjectivesTo explore the risk factors and predictors of a poor prognosis in influenza and IPA co ‐infection.MethodsWe included patients with confirmed influenza during the 2017 to 2018 influenza season and cases of influenza and IPA co ‐infection in the literature.ResultsA total of 64 patients with influenza infection were admitted to ICU. Of these patients, 18 were co ‐infected with IPA. Others were assigned to the control group (n=46). A total of 45 patients from the literature w...
Source: The Clinical Respiratory Journal - January 20, 2019 Category: Respiratory Medicine Authors: Linna Huang, Nannan Zhang, Xu Huang, Shuyu Xiong, Yingying Feng, Yi Zhang, Min Li, Qingyuan Zhan Tags: Original Article Source Type: research

Comparison of prediction value of four bleeding risk scores for pulmonary embolism with anticoagulation: a real ‐world study in Chinese patients
ConclusionsOnly the Kearon score appeared to have more accuracy in predicting the risk of MB. Further large prospective studies are needed to externally validate a BRS for CRB.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 19, 2019 Category: Respiratory Medicine Authors: Zhu Zhang, Jieping Lei, Zhenguo Zhai, Yuanhua Yang, Jun Wan, Wanmu Xie, Chen Wang Tags: Original Article Source Type: research

Temporal trends in survival following ward ‐based NIV for acute hypercapnic respiratory failure in patients with COPD
ConclusionIn ‐hospital mortality remained stable and LOS decreased over time, despite greater comorbidity and more severe AHRF in COPD patients treated for the first time with ward‐based NIV.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 19, 2019 Category: Respiratory Medicine Authors: Samuel P. Trethewey, Ross G. Edgar, Julien Morlet, Rahul Mukherjee, Alice M. Turner Tags: Brief Report Source Type: research

The Effect of Isolated Nocturnal Oxygen Desaturations on Serum hs ‐CRP and IL‐6 in Patients with Chronic Obstructive Pulmonary Disease
AbstractIntroductionA majority of patients with chronic obstructive pulmonary disease (COPD) die of cardiovascular disease (CVD), yet the mechanisms responsible for this association are not fully understood. It remains unknown if isolated nocturnal oxygen desaturation (iNOD) could be one of the potential pathways by which the “inflammatory COPD” phenotype leads to CVD.ObjectivesWe aimed to evaluate if COPD patients who meet the Medicare guidelines for nocturnal oxygen therapy (iNOT+) had higher serum hs ‐CRP and IL‐6 than those who did not meet guidelines for iNOT (iNOT‐).MethodsPatients with moderate to ...
Source: The Clinical Respiratory Journal - January 14, 2019 Category: Respiratory Medicine Authors: Madalina M. Macrea, Robert L. Owens, Thomas Martin, Dan Smith, Kris Ann Oursler, Atul Malhotra Tags: Original Article Source Type: research

Serum Cardiac Troponin Elevation Predicts Mortality in Patients with Pulmonary Hypertension: A Meta ‐Analysis of 8 Cohort Studies
ConclusionsAlthough different studies detected the expression cTnT or cTnI by various methods, the mortality in the cTn ‐positive group was higher than that in the cTn‐negative group. Serum cTn elevation emerged as an independent predictor of increased risk of mortality in PH patients.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 13, 2019 Category: Respiratory Medicine Authors: Shuang ‐Lan Xu, Jiao Yang, Chun‐Fang Zhang, Shuang‐Yan Xu, Fang‐Yun Zhao, Li‐Qiong Liu, Chun‐Lin Xie, Xi‐Qian Xing, Yun Zhu Tags: Review Article Source Type: research

Paediatric asthma prevalence: The first national population ‐based survey in Iran
AbstractBackgroundThe actual prevalence of paediatric asthma as a worldwide chronic disease has been surveyed in developed countries. However, no sufficient survey has been conducted in most of the eastern developing countries. Herein, we took measures to evaluate the prevalence of paediatric asthma in Iran.MethodsIn this national cross ‐sectional study, the prevalence of asthma symptoms was estimated throughout the country using a randomized multistage stratified cluster sampling method in 16 410 and 16 850 individuals aged 6‐7 and 13‐14 years, respectively. A validated questionnaire including core qu...
Source: The Clinical Respiratory Journal - January 11, 2019 Category: Respiratory Medicine Authors: Mohammad Reza Fazlollahi, Mehdi Najmi, Mojtaba Fallahnezhad, Nastaran Sabetkish, Anoshirvan Kazemnejad, Katayoon Bidad, Raheleh Shokouhi Shoormasti, Maryam Mahloujirad, Zahra Pourpak, Mostafa Moin Tags: ORIGINAL ARTICLE Source Type: research

New insights and improved strategies for the management of primary spontaneous pneumothorax
In conclusion, PSP pathophysiology and management are still under investigation. Results of recently published and ongoing studies should be more widely implemented in clinical practice.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 7, 2019 Category: Respiratory Medicine Authors: J érôme Plojoux, Marios Froudarakis, Jean‐Paul Janssens, Paola M. Soccal, Jean‐Marie Tschopp Tags: Series on Pleural Diseases Source Type: research

Lung hypoperfusion in children with complicated pneumonia may be assessed by Doppler ultrasound of the main pulmonary arteries
This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 4, 2019 Category: Respiratory Medicine Authors: Luis Moral, Ismael Mart ín, Ana Fernández, Paola Cárdenas, Teresa Toral Tags: Letter to the Editor Source Type: research

Identification of Genomic Copy Number Variations in Lung Benign Metastasizing Leiomyomatosis
ConclusionThis study remarks the relevance of submicroscopic chromosomal analysis of unusual pathologic conditions such as Benign Metastasizing Leiomyomatosis. This propitiate a better understanding of the molecular basis on the development of the pathology, in order to reckon on minimally invasive diagnostic methods, and to design appropriate treatments. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 29, 2018 Category: Respiratory Medicine Authors: Everardo Hern ández‐Plata, Ana Claudia Velázquez‐Wong, Carmina Jiménez‐Ramírez, Fernando Fernández‐Ramírez, Luz María Galicia‐Sánchez, César Antonio Flores‐García, José Manuel Hernández‐Hernández, Haydeé Rosas‐Vargas, Tags: Original Article Source Type: research

Comparison of two lung cancer screening scores among patients with chronic obstructive pulmonary disease – a community study
AbstractIntroductionBased on the National Lung Cancer Screening Trial (NLST), guidelines on screening programs for lung cancer have recommended low ‐dose computed tomography (LDCT). De Torres et al. made a score for COPD patients (COPD‐LUCSS) to improve their selection criteria.ObjectiveTo examine and compare the discriminating value of both scores in a community based cohort of COPD patients.Methods422 ever ‐smokers with COPD from the GenKOLS study in Bergen were merged with the Cancer Registry of Norway. We divided the patients into groups of high and low risk according to the COPD‐LUCSS and the NLST criteri...
Source: The Clinical Respiratory Journal - December 29, 2018 Category: Respiratory Medicine Authors: Ane Aamli Gagnat, Amund Gulsvik, Per Bakke, Miriam Gjerdevik Tags: Original Article Source Type: research

Small Cell Lung Cancer in the Young: Characteristics, Diagnosis, and Outcome Data
AbstractBackgroundPatients with small cell lung cancer (SCLC) younger than 40 years are limited in number. Our research aimed to assess the characteristics, diagnosis, and outcomes of this patient population.MethodsRecords of patients under the age of 40 with SCLC at the Chinese Academy of Medical Sciences between January 2006 and December 2015 were reviewed and evaluated.ResultsOne hundred and three patients (67.0% limited ‐stage, 33.0% extensive‐stage) were included, along with 54 (52.4%) never‐smokers. The median diagnostic interval and the median survival time (MST) were 51.0 days and 24.0 months, respectively. A...
Source: The Clinical Respiratory Journal - December 26, 2018 Category: Respiratory Medicine Authors: Shiyu Jiang, Xuezhi Hao, Junling Li, Xingsheng Hu, Zefen Xiao, Hongyu Wang, Yan Wang, Yan Sun, Yuankai Shi Tags: Original Article Source Type: research

Issue Information
The Clinical Respiratory Journal, Volume 12, Issue 12, Page 2625-2626, December 2018. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 25, 2018 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Adequacy of Ebus ‐Tbna Specimen For Mutation Analysis of Lung Cancer
ConclusionThe study demonstrated that EBUS ‐TBNA provides adequate material for mutation analysis in patients with newly diagnosed adenocarcinoma or NOS lung cancer.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 24, 2018 Category: Respiratory Medicine Authors: Tugba Cicek, Ayperi Ozturk, Ayd ın Yılmaz, Zafer Aktas, Funda Demirag, Nalan Akyurek Tags: Original Article Source Type: research

Subglottic perioperative airway – tube inflation via randomized evaluation with variable syringe size (spair‐tire) study
ConclusionAlthough both 5mL and 10mL syringes resulted in elevated cuff pressures after intubation, 5mL syringes resulted in a lower degree of elevation. Use of a 5mL syringe should be considered when inflating the endotracheal cuff to possibly reduce patient harm secondary to elevated cuff pressures. Further studies assessing smaller syringe sizes to reduce cuff pressures are warranted.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 23, 2018 Category: Respiratory Medicine Authors: George W. Williams, Carlos A. Artime, Omar L. Mancillas, Tariq A. Syed, Tyrone Burnett, Russell Graham, Jason Tam, Carin A. Hagberg Tags: Original Article Source Type: research

Is there any role for Thoracoscopy in the diagnosis of benign pleural Effusions
This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 21, 2018 Category: Respiratory Medicine Authors: Stavros Anevlavis, Csaba Varga, Tse Hoi Nam, Raymond Wong Chun Man, Artemios Demetriou, Nitin Jain, Anthony Lanfranco, Marios E. Froudarakis Tags: Series on Pleural Diseases Source Type: research

Pleura revisited: from histology and pathophysiology to pathology and molecular biology
This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 18, 2018 Category: Respiratory Medicine Authors: Georgia Karpathiou, Michel Peoc'h Tags: Series on Pleural Diseases Source Type: research

Could SUVmax be an auxiliary parameter in the clinical management of pulmonary hydatid disease?
ConclusionHigher SUVmax values may be a useful parameter in the diagnosis of complicated pulmonary hydatid disease. FDG ‐PET may provide guidance for determining the priority of lesion for surgery in cases with multiple lesions and may be helpful to evaluate the response to medical treatment.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - December 17, 2018 Category: Respiratory Medicine Authors: Ozlem Ozmen, Ebru Tatci, Inci Uslu Biner, Gokturk Findik, Ulku Yilmaz, Hakan Erturk, Funda Demirag Tags: Original Article Source Type: research

Bibliometric analysis of scientific publications in respiratory journals from China and other top ‐ranking countries between 2007 and 2017
In this study, we aimed to compare the quantity and quality of scientific publications in the field of respirology from the USA, the UK, Germany, Canada and China.MethodsArticles published in 58 respiratory journals from 2007 to 2017 were screened with Science Citation Index Expanded database. The number of total and annual articles, article types, impact factor (IF), h ‐index, citations and articles in the high‐impact journals from the corresponding country were collected for quantity and quality comparisons. The correlation of socioeconomic factors and annual publications was also analyzed.ResultsA total of 93078 art...
Source: The Clinical Respiratory Journal - December 10, 2018 Category: Respiratory Medicine Authors: Yulan Qu, Chen Zhang, Zhenli Hu, Yunye Ning, Chen Kong, Yan Shang, Chong Bai Tags: Original Article Source Type: research

Hidden morbidity: the results of a collaborative community Chronic Obstructive Pulmonary Disease screening initiative
AbstractChronic obstructive pulmonary disease (COPD) often goes unrecognised resulting in people living with the disease without a diagnosis. Screening of asymptomatic individuals is not recommended but case ‐finding is encouraged to detect early disease. We investigated the characteristics, symptom burden and flow of participants taking part in a community‐based COPD screening initiative in a city with high smoking prevalence.Screening was undertaken during four events in public locations over a 2 ‐week period. Participants completed symptom questionnaires and FEV‐1/FEV‐6 measurement. The criteria for being cons...
Source: The Clinical Respiratory Journal - December 2, 2018 Category: Respiratory Medicine Authors: Michael G Crooks, Joanne L Thompson, Helena Cummings, Karen Watkins, Nicola Jackson, Shaneen Platten, Cheryl Evans, Shoaib Faruqi Tags: Original Article Source Type: research

CD146 ‐Mediated Acquisition of Stemness Phenotype Enhances Tumor Invasion and Metastasis after EGFR‐TKI Resistance in Lung Cancer
ConclusionsCD146 molecule contributes to the stemness phenotype and migration in EGFR ‐TKI resistance cells. CD146 might be a potential therapeutic target for EGFR‐TKI resistance lung cancer or metastasis prevention.This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 27, 2018 Category: Respiratory Medicine Authors: Fan Zhang, Jia Wang, Xiaobo Wang, Nan Wei, Haiyang Liu, Xiaoju Zhang Tags: Original Article Source Type: research