The Effect Of Pulmonary Rehab ılıtatıon On Smokıng And Health Outcomes In Copd Patıents
AbstractObjectivesAlthough several positive effects of pulmonary rehabilitation (PR) are known in COPD patients, the results of PR in smoker COPD patients are unclear. We aimed to compare the effect of PR on smoking behavior and health outcomes between COPD patients who are smoker and ex ‐smoker.MethodsIn our study; 62 COPD patients (31 of them active smoker and 31 of them were ex ‐smoker) who completed in an 8‐week outpatient PR program were included. Pulmonary function test, blood gas analysis, mMRC Dyspnea Scale, 6‐minute walk test, St. George’s Respiratory Questionnaire, SF‐36 Quality Of Life Questionna...
Source: The Clinical Respiratory Journal - April 8, 2021 Category: Respiratory Medicine Authors: Hulya Sahin, Ilknur Naz Tags: ORIGINAL ARTICLE Source Type: research

Clinical relevance of emphysema in patients hospitalized with community ‐acquired pneumonia: clinical features and prognosis
ConclusionsThe presence of emphysema in CAP patients was associated with a more severe form of CAP, a longer hospital stay, and a lower incidence of complicated parapneumonic effusion or empyema. Moreover, CAP patients with severe emphysema exhibited higher 30 ‐day mortality than those without emphysema. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 7, 2021 Category: Respiratory Medicine Authors: Hyewon Seo, Seung ‐Ick Cha, Kyung Min Shin, Jae Kwang Lim, Won Kee Lee, Ji‐Eun Park, Sunji Park, Sun Ha Choi, Yong‐Hoon Lee, Seung‐Soo Yoo, Shin‐Yup Lee, Jaehee Lee, Chang‐Ho Kim, Jae‐Yong Park Tags: ORIGINAL ARTICLE Source Type: research

Use of GLP1RAs and occurrence of respiratory disorders: a meta ‐analysis of large randomized trials of GLP1RAs
ConclusionGLP1RAs show the reduced trends in the risks of 9 kinds of respiratory disorders (e.g., pneumonia, SCCL, asthma, and COPD), but the increased trend in the risk of ILD. However, these findings need to be validated by further studies due to the low incidence rates of all the respiratory disorders. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 7, 2021 Category: Respiratory Medicine Authors: Jin ‐Ping Wei, Chang‐Lin Yang, Wen‐Hua Leng, Liang‐Liang Ding, Guo‐Hou Zhao Tags: BRIEF REPORT Source Type: research

How is the education component of pulmonary rehabilitation delivered in practice – is it patient‐centred?
ConclusionsContent and delivery of educational topics was varied, and no consistent outcome measure to assess the effectiveness of education was used.Practice implicationsEducation needs to be delivered in a patient centred way tailoring for literacy skills using a range of different teaching approaches and aids. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 7, 2021 Category: Respiratory Medicine Authors: Nicola J Roberts, Lisa Kidd, Kim Kirkwood, Jane Cross, Martyn R Partridge Tags: ORIGINAL ARTICLE Source Type: research

Clinical and etiological analysis of co ‐infections and secondary infections in COVID‐19 patients: an observational study
AbstractTo investigate the role of co ‐infections and secondary infections in disease severity of hospitalized individuals with COVID‐19, a retrospective study was carried out between January 11 and March 1, 2020 among 408 laboratory confirmed COVID‐19 patients in China. These patients were divided into three groups based on disea se severity: mild or moderate, severe, or critically ill. Microbiological pathogens in blood, urine, and respiratory tract specimens were detected by the combination of culture, serology, polymerase chain reaction (PCR), and metagenomic next‐generation sequencing (mNGS). The median age of...
Source: The Clinical Respiratory Journal - April 6, 2021 Category: Respiratory Medicine Authors: Shuyan Chen, Qing Zhu, Yanyu Xiao, Chi Wu, Zhaofang Jiang, Lei Liu, Jiuxin Qu Tags: ORIGINAL ARTICLE Source Type: research

Heart rate variability changes by non ‐invasive ventilation in obesity hypoventilation syndrome
ConclusionThe enhanced respiration due to the application of BiPAP can improve the performance of autonomous nervous and cardiovascular systems, in terms of HRV. Moreover, it is suggested to consider some HRV parameters to control the cardiovascular side ‐effects of OHS and confine the resulting mortality rate in long term. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 5, 2021 Category: Respiratory Medicine Authors: Babak Amra, Samin Balouchianzadeh, Forogh Soltaninejad, Christoph Schoebel, Ingo Fietze, Mohammad Hossein Bateni, Morteza Abdar Esfahani, Thomas Penzel Tags: ORIGINAL ARTICLE Source Type: research

Efficacy of endobronchial ultrasound ‐guided transbronchial biopsy without guide sheath for small peripheral pulmonary lesions (≤15 mm): A retrospective cohort study
ConclusionsEBUS ‐TBB without GS is an effective and safe procedure for diagnosing small PPLs (≤15 mm) compared to that with GS. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 3, 2021 Category: Respiratory Medicine Authors: Takayasu Ito, Masami Matsumoto, Mihoko Kujime, Takashi Kohnoh, Akira Fukushima, Tatsuya Takagi, Yukiko Fukushima, Takaaki Kasahara Tags: ORIGINAL ARTICLE Source Type: research

Fatigue: A forgotten symptom of asthma
The objective of this study was to determine the prevalence of fatigue in asthmatic patients, the effect of fatigue on asthma quality of life and the relationship between fatigue and anxiety/depressionMaterials and methodsThis prospective cross ‐sectional study was conducted in Uludağ University Faculty of Medicine, Department of Immunology and Allergic Diseases outpatient clinic from June 2019 to December 2019. Fatigue was assessed using the Checklist Individual Strength‐Fatigue (CIS‐Fatigue), psychological distress was assessed us ing the Beck Depression Inventory (BDI) and the Beck Anxiety Inventory (BAI) and qua...
Source: The Clinical Respiratory Journal - March 30, 2021 Category: Respiratory Medicine Authors: Fatma Esra G ünaydın, Dane Ediger, Müge Erbay Tags: ORIGINAL ARTICLE Source Type: research

Sputum processing by mechanical dissociation: A rapid alternative to traditional sputum assessment approaches
ConclusionThis cost ‐effective method of sputum processing could provide a more pragmatic, sustainable means of directly monitoring the airway milieu. Therefore, we recommend this method be taken forward for further investigation. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 29, 2021 Category: Respiratory Medicine Authors: Clair Barber, Laurie Lau, Jonathan A. Ward, Thomas Daniels, Alastair Watson, Karl J. Staples, Tom M. A. Wilkinson, Peter H. Howarth Tags: ORIGINAL ARTICLE Source Type: research

Subjective sleep ‐related breathing disorders and executive function in children with intermittent or mild persistent asthma
ConclusionIn children with intermittent or mild persistent asthma under the care of private general paediatricians there were no statistically significant differences regarding subjective SBD compared to the healthy controls. Also there were no statistical differences between asthmatic children and controls regarding behavioural correlates of executive function during everyday life. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 28, 2021 Category: Respiratory Medicine Authors: Dimos Gidaris, Stella Stabouli, Kleio Eleftheriou, Dimitrios Cassimos, Don Urquhart, Vasilios Kotsis, Dimitrios Zafeiriou Tags: ORIGINAL ARTICLE Source Type: research

Pentoxifylline or theophylline use in hospitalized COVID ‐19 patients requiring oxygen support
ConclusionIn this retrospective study, theophylline and pentoxifylline were associated with an increase in ROX score and nominal decreases in CRP and mortality. Treatment was safe with few adverse reactions documented. We believe that this study could the basis for randomized ‐controlled trials to further explore these drugs’ role in COVID‐19. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 28, 2021 Category: Respiratory Medicine Authors: Geoffrey C. Wall, Hayden L. Smith, Matthew W. Trump, Jason D. Mohr, Samuel P. DuMontier, Becca L. Sabates, Iaswarya Ganapathiraju, Tim J. Kable Tags: BRIEF REPORT Source Type: research

The use of transbronchial cryobiopsy for diffuse parenchymal lung disease in critically ill patients with acute hypoxemic respiratory failure —A case series
ConclusionsTBC is a feasible technique with an acceptable complication rate and a fairly high histopathological yield in ICU patients with DPLD and acute hypoxemic respiratory failure. Appropriate diagnosis can be crucial in making management decisions for these patients. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 26, 2021 Category: Respiratory Medicine Authors: Atul Matta, Ena Gupta, Zulma Swank, Alejandro Aragaki ‐Nakahodo, Joseph Cooley, Danielle N. Caudell‐Stamper, Sadia Benzaquen Tags: ORIGINAL ARTICLE Source Type: research

Self ‐reported sleep disturbance and mild cognitive impairment in COPD patients with severe airflow limitation
AbstractIntroductionCOPD has multiple extrapulmonary manifestations and the latest studies have focused on cognitive dysfunction effects on sleep quality. The purpose of this study is to assess if there is a relationship between sleep quality and cognitive decline in COPD patients with severe airflow limitation.MethodsWe performed an observational study to determine if there is a link between cognitive function and sleep quality. The included patients were divided into two groups: a group with COPD patients and control group. We evaluated lung volumes, cognitive function, sleep quality and disease impact on the quality of ...
Source: The Clinical Respiratory Journal - March 25, 2021 Category: Respiratory Medicine Authors: Paula Irina Barata, Monica Steluta Marc, Emanuela Tudorache, Mirela Frandes, Alexandru Florian Crisan, Dana Cristina Olar, Cristian Oancea Tags: ORIGINAL ARTICLE Source Type: research

Peripapillary vascular density and retinal nerve fibre layer changes in patients with chronic obstructive pulmonary disease
In this study, we aimed to investigate the radial peripapillary capillary (RPC) density and retinal nerve fibre layer (RNFL) thickness changes in patients with COPD.MethodsThe right eyes of 35 patients with COPD and 35 healthy controls were evaluated with optical coherence tomography angiography (OCTA). RPC density values and RNFL thicknesses were measured and compared.ResultsThe mean inside disc vascular density and the mean peripapillary vascular density values were lower in the COPD group (p = 0.002,p 
Source: The Clinical Respiratory Journal - March 24, 2021 Category: Respiratory Medicine Authors: Abdurrahman Alpaslan Alkan, Ey üp Düzgün, Müfide Arzu Özkarafakılı Tags: ORIGINAL ARTICLE Source Type: research

Effectiveness of noninvasive ventilation in COVID ‐19 related‐acute respiratory distress syndrome
ConclusionPrevious studies conducted on patients undergoing invasive mechanical ventilation showed higher mortality rate than the present study. Our data showed that NIV can avoid intubation in almost half of the patients. Therefore, this data could reassure clinicians who would consider using NIV in COVID ‐19 ARDS‐related treatment. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 24, 2021 Category: Respiratory Medicine Authors: Francesco Menzella, Chiara Barbieri, Matteo Fontana, Chiara Scelfo, Claudia Castagnetti, Giulia Ghidoni, Patrizia Ruggiero, Francesco Livrieri, Roberto Piro, Luca Ghidorsi, Gloria Montanari, Giorgia Gibellini, Eleonora Casalini, Francesco Fal Tags: ORIGINAL ARTICLE Source Type: research

Multidisciplinary team obviates biopsy in most patients with diffuse parenchymal lung diseases —A retrospective study from India
ConclusionThe MDT plays a crucial role in the diagnosis of DPLDs. Not every pattern requires biopsy confirmation. However, an idiopathic non ‐specific interstitial pneumonitis diagnosis by the MDT should probably be better confirmed by biopsy. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 24, 2021 Category: Respiratory Medicine Authors: Bangalore Venkataraman Murali Mohan, Syed Zulkharnain Tousheed, Poojaramuddanahally Hanumantharayappa Manjunath, Malapaka Ramakrishna Ravichandra, Ramanjaneya Ranganatha, Vellaichamy M. Annapandian, M. Hemanth Kumar, Chandrasekar Sagar Tags: ORIGINAL ARTICLE Source Type: research

Successful dacomitinib treatment after osimertinib resistance in a patient with lung adenocarcinoma
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 17, 2021 Category: Respiratory Medicine Authors: Katsunori Kagohashi, Toshihiro Shiozawa, Kunihiko Miyazaki, Hiroaki Satoh Tags: LETTER TO THE EDITOR Source Type: research

Effectiveness of noninvasive ventilation in COVID ‐19 related‐ARDS
ConclusionPrevious studies conducted on patients undergoing invasive mechanical ventilation showed higher mortality rate than the present study. Our data showed that NIV can avoid intubation in almost half of the patients. Therefore, this data could reassure clinicians who would consider using NIV in COVID ‐19 ARDS‐related treatment. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 17, 2021 Category: Respiratory Medicine Authors: Francesco Menzella, Chiara Barbieri, Matteo Fontana, Chiara Scelfo, Claudia Castagnetti, Giulia Ghidoni, Patrizia Ruggiero, Francesco Livrieri, Roberto Piro, Luca Ghidorsi, Gloria Montanari, Giorgia Gibellini, Eleonora Casalini, Francesco Fal Tags: ORIGINAL ARTICLE Source Type: research

Heart Rate Variability Changes by Non Invasive Ventilation in Obesity Hypoventilation Syndrome
AbstractNon ‐Invasive Positive Pressure Ventilation (NIPPV) is known to enhance hypoventilation, and is particularly adopted as a treatment for patients diagnosed withObesity Hypoventilation Syndrome (OHS). The augmented risk of cardiovascular morbidity is known as a side effect of OHS. In this paper, this inference is examined that hypoventilation and the increased risk of morbidity can be diagnosed via assessment of changes inHeart Rate Variability (HRV). More specifically, the study investigates the effect of NIPPV on both HRV and hypoventilation among OHS patients. The linear relationship between different HRV measur...
Source: The Clinical Respiratory Journal - March 16, 2021 Category: Respiratory Medicine Authors: Babak Amra, Samin Balouchianzadeh, Forogh Soltaninejad, Christoph Schoebel, Ingo Fietze, Mohammad Hossein Bateni, Morteza Abdar Esfahani, Thomas Penzel Tags: ORIGINAL ARTICLE Source Type: research

Effect of Healthcare Benefits on Short ‐term Adherence of Positive Airway Pressure Therapy
The objective of this study was to assess the impact of healthcare benefits on adherence to positive airway pressure (PAP) therapy in obstructive sleep apnea (OSA) patients.MethodsMedical records of OSA patients at the Veterans Health Service Medical Center were retrospectively reviewed. OSA patients were assigned to two groups as the date of prescribing PAP: after (=Group A) and before (=Group B) July 1, 2018 when PAP therapy starts to be included in healthcare insurance coverage for OSA patients in South Korea. PAP adherence was compared over a 3 ‐month period between the two groups; subjective improvement after therap...
Source: The Clinical Respiratory Journal - March 15, 2021 Category: Respiratory Medicine Authors: Taehun Lim, Sung Hwan Lim, Beom Mo Koo, Junho Hwang, Joo Hyung Oh, Jihye Rhee, Pona Park Tags: ORIGINAL ARTICLE Source Type: research

Multidisciplinary team obviates biopsy in most patients with diffuse parenchymal lung diseases – a retrospective study from India
ConclusionThe MDT plays a crucial role in the diagnosis of DPLDs. Not every pattern requires biopsy confirmation. However, an iNSIP diagnosis by the MDT should probably be better confirmed by biopsy. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 15, 2021 Category: Respiratory Medicine Authors: Bangalore Venkataraman Murali Mohan, Syed Zulkharnain Tousheed, Poojaramuddanahally Hanumantharayappa Manjunath, Malapaka Ramakrishna Ravichandra, Ramanjaneya Ranganatha, Vellaichamy M. Annapandian, M. Hemanth Kumar, Sagar Chandrasekar Tags: ORIGINAL ARTICLE Source Type: research

Chronic Cough is Associated with Depressive Mood in Women Regardless of Smoking Status and Lung Function
ABSTRACTBackgroundChronic cough is a common respiratory symptom, and, if persistent, the patient ’s quality of life can worsen and result in a depressive mood, or vice versa. Although previous reports suggest a relationship between chronic cough and depression, we further investigated this relationship according to smoking status and lung function.MethodsThis observational study used cross ‐sectional data from the 6th Korean National Health and Nutrition Examination Survey (2014 and 2016). Propensity score matching using age, sex, smoking status and lung function was performed for participants with and without chro...
Source: The Clinical Respiratory Journal - March 14, 2021 Category: Respiratory Medicine Authors: I Re Heo, Ju ‐Young Kim, Se‐Il Go, Tae Hoon Kim, Sun Mi Ju, Jung‐Wan Yoo, Seung Jun Lee, Yu Ji Cho, Yi Yeong Jeong, Jong Deog Lee, Ho Cheol Kim Tags: ORIGINAL ARTICLE Source Type: research

The impact of a telemedicine intervention on home non ‐invasive ventilation in a rural population with advanced COPD
AbstractIntroductionRural regions have unique challenges with implementation of new therapies upon discharge from the hospital due to multiple barriers.ObjectivesWe investigated the effect of home non ‐invasive ventilation (NIV) plus implementation of a call center following hospitalization for acute exacerbations of COPD (chronic obstructive lung disease) on NIV usage and readmissions.MethodsIn this prospective pilot study, consecutive patients were screened at our institution for diagnosis of hypercarbic respiratory failure or COPD exacerbation from 2018 until 2019. Patients with more than 2 admissions in the last year...
Source: The Clinical Respiratory Journal - March 12, 2021 Category: Respiratory Medicine Authors: Rachel Leonard, Michael Forte, Devanshi Mehta, Hassan Mujahid, Robert Stansbury Tags: ORIGINAL ARTICLE Source Type: research

Association of Depression with Improper Use of Inhaler Devices by Patients with Obstructive Disease
ConclusionsAs a result, the presence of depression symptoms may increase improper use of inhaler devices. Further research is needed to determine if screening for and treating depression improves improper use of inhaler devices and obstructive disease outcomes in this population. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 11, 2021 Category: Respiratory Medicine Authors: Sertan Bulut, Harun Karamanli, P ınar Akın Kabalak Tags: ORIGINAL ARTICLE Source Type: research

Titration and Follow ‐up for Home Noninvasive Positive Pressure Ventilation in Chronic Obstructive Pulmonary Disease: the potential role of Tele‐monitoring and the Internet of things
ConclusionIoT ‐based management of home NIPPV, such as home titration and follow‐up with the use of tele‐monitoring, are emerging and yielding positive findings. However, clear conclusions based on RCT of tele‐monitoring in COPD patients with NIPPV at home are only a few and large‐scale multicenter stud ies are required for replication and further validation. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 11, 2021 Category: Respiratory Medicine Authors: Wei peng Jiang, Linlin Wang, Yuan lin Song Tags: REVIEW ARTICLE Source Type: research

Issue Information
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 10, 2021 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Proton Pump Inhibitor Treatment Improves Pulmonary Function in Acute Exacerbations of COPD Patients with 24 ‐hour Dx‐pH Monitoring‐diagnosed Laryngopharyngeal Reflux
ConclusionStudy results indicate unreliability of RSI threshold for LPR diagnosis. Combination of symptoms, endoscopic findings, and 24 ‐hour Dx‐pH monitoring is recommended for LPR diagnosis and PPI treatment decisions, especially in difficult‐to‐control or severe COPD patients. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 10, 2021 Category: Respiratory Medicine Authors: Huaying Wang, Zhongming Fu, Peihong Xu, Xiao Gu, Xiaofei Chen, Wanjun Yu Tags: ORIGINAL ARTICLES Source Type: research

Prevalence and screening of specific aeroallergens in Chinese male patients with chronic obstructive pulmonary disease: a retrospective cross ‐sectional observational study
AbstractIntroductionSensitization to aeroallergens were linked to severe symptoms and frequent exacerbations in chronic obstructive pulmonary disease (COPD) patients. Elevated serum total immunoglobulin E (tIgE) level is a hallmark of allergic COPD patients. Phadiatop test exhibited high sensitivity for predicting specific aeroallergens (SAs) sensitization. However, the prevalence of aeroallergens, the value of Phadiatop test, alone or combined with tIgE, for predicting aeroallergens sensitization in male COPD patients have not been explored in China.ObjectivesTo explore the prevalence and predictors of aeroallergens in th...
Source: The Clinical Respiratory Journal - March 9, 2021 Category: Respiratory Medicine Authors: Lili Hou, Zhengyu Li, Luhong Bao, Zhiguo Zhou, Shanqun Li, Xin Zhou, Min Zhang Tags: ORIGINAL ARTICLE Source Type: research

Radiomics study on pulmonary infarction mimicking community ‐acquired pneumonia
ConclusionsRadiomics features generated from noncontrast ‐enhanced CT images allow PI to be differentiated from CAP with considerable accuracy. The radiomics‐based method could provide useful information in clinical practice. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 9, 2021 Category: Respiratory Medicine Authors: Li Gao, Yuze Li, Zhenguo Zhai, Tian Liang, Qiang Zhang, Sheng Xie, Huijun Chen Tags: ORIGINAL ARTICLE Source Type: research

Characteristic appearance of the oropharynx in patients with postnasal drip (PND) ‐induced cough
ConclusionPatients with acute PND ‐induced cough have a component of acute upper respiratory infection, because of high probability of a sore or scratchy throat and fever as symptom. A reddish curtain sign may be a useful finding for identifying PND‐induced cough in these cases. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 9, 2021 Category: Respiratory Medicine Authors: Katsuyuki Tomita, Tomoyuki Ikeuchi, Hirokazu Touge, Yosuke Nakamura, Yuko Yamamoto, Hiromi Takeuchi, Akira Yamasaki Tags: ORIGINAL ARTICLE Source Type: research

Hospital ‐at‐home for chronic obstructive pulmonary disease exacerbation; Will it be an effective readmission avoidance model?
AbstractObjectivesHospital ‐at‐home (HAH),a pioneering health care model, is an accepted alternative to hospital treatment for patients with a chronic obstructive pulmonary disease (COPD) exacerbations.The aim of the present study was to analyze the effectiveness of HAH for patients with COPD exacerbations.MethodsTwo hundred six patients with COPD exacerbations who were admitted to our emergency room (ER) received the HAH model between January 2008 and March 2010. Hospitalization rates, admission to emergency room, admissions to outpatient clinic, and the total number of days in hospital were recorded before and after ...
Source: The Clinical Respiratory Journal - March 8, 2021 Category: Respiratory Medicine Authors: Dicle Kaymaz, Ipek Candemir, Pinar Ergun, Pervin Demir Tags: ORIGINAL ARTICLE Source Type: research

Peripapillary Vascular Density and Retinal Nerve Fiber Layer Changes in Patients with Chronic Obstructive Pulmonary Disease
In this study, we aimed to investigate the radial peripapillary capillary (RPC) density and retinal nerve fiber layer (RNFL) thickness changes in patients with COPD.MethodsThe right eyes of 35 patients with COPD and 35 healthy controls were evaluated with optical coherence tomography angiography (OCTA). RPC density values and RNFL thicknesses were measured and compared.ResultsThe mean inside disc vascular density and the mean peripapillary vascular density values were lower in the COPD group (p=0.002, p
Source: The Clinical Respiratory Journal - March 8, 2021 Category: Respiratory Medicine Authors: Abdurrahman Alpaslan Alkan, Ey üp Düzgün, Müfide Arzu Özkarafakılı Tags: ORIGINAL ARTICLE Source Type: research

E ‐cigarette users are associated with asthma disease: a meta‐analysis
ConclusionIn short, in this meta ‐analysis, we found that current or former use of e‐cigarettes are associated with the prevalence of asthma. However, the specific relationship required more rigorous design for further verification. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 8, 2021 Category: Respiratory Medicine Authors: Shaojing Xian, Yongxing Chen Tags: REVIEW ARTICLE Source Type: research

Procalcitonin ‐guided Antibiotic Therapy in AECOPD Patients: Overview of Systematic Reviews
ConclusionCurrent SRs show that PCT ‐guided antibiotic therapy could be employed by clinicians in treatment of AECOPD. However, the high‐quality evidence of outcomes is lacking, further intensive exploration should be carried out on the precise role of PCT‐guided antibiotic therapy on AECOPD. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 8, 2021 Category: Respiratory Medicine Authors: Jiaqi Di, Xuanlin Li, Yang Xie, Shuguang Yang, Xueqing Yu Tags: REVIEW ARTICLE Source Type: research

Mean platelet volume combined red cell distribution width is affected by many conditions
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 6, 2021 Category: Respiratory Medicine Authors: Cihan Bedel, Mustafa Korkut Tags: LETTER TO THE EDITOR Source Type: research

Epidemiology and issues of NIV ‐treated AECOPD patients with hypercapnic respiratory failure in Shanghai: A multicentre retrospective survey
AbstractObjectiveTo investigate the epidemiology, clinical features, treatment and outcome of Noninvasive ventilation (NIV) ‐treated acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients in secondary hospitals of Shanghai.MethodRelying on Shanghai alliances for respiratory diseases, a retrospective observational study was performed in 34 secondary hospitals of Shanghai. The AECOPD patients treated with NIV and admitted to the respiratory department or respiratory intensive care unit were recruited between December 1, 2016, and November 30, 2017.ResultsThere were 555 patients finally recruited in t...
Source: The Clinical Respiratory Journal - February 27, 2021 Category: Respiratory Medicine Authors: Sheng ‐mei Wang, Feng‐ying Zhang, Chun‐ling Du, Xiong‐biao Wang, Fan Li, Jing‐qing Hang, Yuan‐jing Chen, Ke‐wen Cheng, Lei Zhao, Xiao‐yan Jin, Jin‐dong Shi, Zhi‐jun Jie, Jie‐ming Qu, Shanghai Primary Respiratory Care Uni Tags: ORIGINAL ARTICLE Source Type: research

Occult Lymph Node Metastasis in Radiologic Stage I Non ‐small Cell Lung Cancer: The Role of Endobronchial Ultrasound
AbstractRationaleThe use of endobronchial ultrasound ‐guided transbronchial needle aspiration (EBUS‐TBNA) is currently recommended for staging non‐small cell lung cancer (NSCLC) in centrally‐located tumors, tumors> 3 cm, or with radiologic evidence of lymph node (LN) metastasis. Current guidelines don ’t recommend staging EBUS‐TBNA in patients with stage I NSCLC who don’t have any of the aforementioned conditions.ObjectiveWe hypothesize that using EBUS ‐TBNA is useful for detecting occult metastasis in radiologic stage I NSCLC.MethodsIn this single ‐center, retrospective study, charts of patien...
Source: The Clinical Respiratory Journal - February 25, 2021 Category: Respiratory Medicine Authors: Faeq R. Kukhon, Xinyue Lan, Scott A. Helgeson, Vichaya Arunthari, Sebastian Fernandez ‐Bussy, Neal M. Patel Tags: ORIGINAL ARTICLE Source Type: research

Mean platelet volume combined red cell distribution width is affected by many conditions
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 24, 2021 Category: Respiratory Medicine Authors: Cihan Bedel, Mustafa Korkut Tags: LETTER TO THE EDITOR Source Type: research

The relationships between serum heart ‐type fatty acid‐binding protein and right ventricular echocardiographic indices in chronic obstructive pulmonary disease
In this study, we assessed the relationships between serum H‐FABP as a marker of cardiac injury and right ventricle (RV) echocardiographic indices in patients with stable COPD.Materials and methodsIn this case ‐control study, 84 participants were investigated (50 COPD patients and 34 healthy subjects). After obtaining consent, 3 mL of fasting whole blood sample was collected from each of the participants to test their serum H‐FABP. Echocardiography was performed on all participants by cardiologists.ResultsSerum H ‐FABP was found to be significantly correlated with smoking history (P 
Source: The Clinical Respiratory Journal - February 24, 2021 Category: Respiratory Medicine Authors: Leili Avesta, Mohammad Reza Aslani, Parastoo Parham, Saeid Sadeghieh ‐Ahari, Hassan Ghobadi Tags: ORIGINAL ARTICLE Source Type: research

Feasibility of manual bronchial branch reading technique in navigating conventional rEBUS bronchoscopy in the evaluation of peripheral pulmonary lesion
AbstractBackgroundAlthough radial endobronchial ultrasound (rEBUS) is an important verification tool in guided bronchoscopy, a navigational route was not provided. Manual airway mapping allows the bronchoscopist to translate the bronchial branching in computed tomography (CT) into a comparable bronchoscopic road map. We aimed to explore the feasibility of this technique in navigating conventional rEBUS bronchoscopy in the localisation of peripheral pulmonary lesion by determining navigation success and diagnostic yield.MethodsRetrospective review of consecutive rEBUS bronchoscopy performed with a 6.2 mm conventional bronch...
Source: The Clinical Respiratory Journal - February 22, 2021 Category: Respiratory Medicine Authors: Sze Shyang Kho, Larry Ellee Nyanti, Chan Sin Chai, Swee Kim Chan, Siew Teck Tie Tags: ORIGINAL ARTICLE Source Type: research

Safety and incidence of complications associated with bronchoscopy in an obese population
ConclusionBronchoscopy under moderate sedation performed in obese patients is safe; however, increased risk may exist with females, increased procedure time and suspected OSA. . (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 20, 2021 Category: Respiratory Medicine Authors: Moiz Salahuddin, Oriana Salamo, Siddharth Karanth, Saadia A. Faiz, Rosa M. Estrada ‐Y‐Martin, Sujith V. Cherian Tags: ORIGINAL ARTICLE Source Type: research

Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma
ConclusionPersistent SABA ‐induced FEV1 >  12%, especially when associated to BE >  300 cells/ml, may be a marker of accelerated lung function decline in severe asthmatics despite maximal step‐5 treatment. The highest bronchodilation associated to the lowest BE levels should be the main goal of asthma treatment to prevent such decline. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 20, 2021 Category: Respiratory Medicine Authors: Bruno Sposato, Marco Scalese, Alberto Ricci, Paola Rogliani, Pierluigi Paggiaro, The Omalizumab Italian Study Group, B. Sposato, M. G. Migliorini, M. Di Tomassi, C. Olivieri, A. Perrella, G. Camiciottoli, R. Maselli, G. Pelaia, M. T. Busceti Tags: BRIEF REPORT Source Type: research

The airway microbiome in COPD, bronchiectasis and bronchiectasis ‐COPD overlap
ConclusionUse of next ‐generation sequencing has revolutionised our detection and understanding of the airway microbiome in chronic respiratory diseases such as COPD and bronchiectasis. Targeted amplicon sequencing reveals important associations between the respiratory microbiome and disease outcome while metagenomics may elucidate functional pathways. How best to apply this information into patient care, monitoring and treatment, however, remains challenging and necessitates further study. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 20, 2021 Category: Respiratory Medicine Authors: Pei Yee Tiew, Tavleen K. Jaggi, Louisa L. Y. Chan, Sanjay H. Chotirmall Tags: REVIEW ARTICLE Source Type: research

The efficacy and safety of therapeutic lung lavage for exogenous lipoid pneumonia: A systematic review
ConclusionsTherapeutic lung lavage might be an effective and safe therapy with long ‐term benefits for ELP. Current studies were all case reports and case series with relatively high risk of bias. Prospective controlled studies are needed to explore the actual efficacy, safety, individualized indications, and optimized treatment procedures of therapeutic lung lavage for ELP. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 20, 2021 Category: Respiratory Medicine Authors: Lianhan Shang, Xiaoying Gu, Sisi Du, Yimin Wang, Bin Cao, Chen Wang, for CAP ‐China Network Tags: REVIEW ARTICLE Source Type: research

Issue Information
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 20, 2021 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

A note in indwelling pleural catheter infections
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 20, 2021 Category: Respiratory Medicine Authors: Avinash Aujayeb Tags: LETTER TO THE EDITOR Source Type: research

Are frailty and patient ‐reported outcomes independent in subjects with asthma? A cross‐sectional observational study
This study examined the possible associations between frailty and patient ‐reported outcomes (PROs) in elderly patients with asthma.MethodsParticipants completed the Kihon Checklist for frailty screening as well as the following tools for measuring generic ‐ and disease‐specific health‐related quality of life (HRQOL) and asthma control; the Medical Outcomes Study 36‐item short form (SF‐36), the Hyland Scale (global scale), the Asthma Quality of Life Questionnaire (AQLQ), the Asthma Control Test (ACT), and the Asthma Control Questionnaire (AC Q).ResultsOf 69 consecutive outpatients with asthma, 38 (55.1%), 21 (3...
Source: The Clinical Respiratory Journal - February 20, 2021 Category: Respiratory Medicine Authors: Masaaki Kusunose, Ryo Sanda, Mio Mori, Ayumi Narita, Koichi Nishimura Tags: ORIGINAL ARTICLE Source Type: research