Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases
Severe pain and impairments in functioning are commonly reported for youth with juvenile fibromyalgia. The prevalence and impact of pain in other diseases commonly managed in pediatric rheumatology comparative... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - November 6, 2019 Category: Rheumatology Authors: Mark Connelly and Jenifer E. Weiss Tags: Research article Source Type: research

Juvenile systemic lupus erythematosus presenting as pancarditis
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with marked variation in its clinical presentation. Juvenile SLE (jSLE) accounts for 15 –20% of all cases and is diagnosed when SLE manifests b... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - November 4, 2019 Category: Rheumatology Authors: D. O ’Leary, C. O’Connor, L. Nertney, E. J. MacDermott, D. Mullane, O. Franklin and O. G. Killeen Tags: Case Report Source Type: research

Complexity in unclassified auto-inflammatory disease: a case report illustrating the potential for disease arising from the allelic burden of multiple variants
Despite recent advances in the diagnosis and understanding of many autoinflammatory diseases, there are still a great number of patients with phenotypes that do not fit any clinically- and/or genetically-defin... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - October 28, 2019 Category: Rheumatology Authors: Lori B. Tucker, Lovro Lamot, Iwona Niemietz, Brian K. Chung, David A. Cabral, Kristin Houghton, Ross E. Petty, Kimberly A. Morishita, Gillian I. Rice, Stuart E. Turvey, William T. Gibson and Kelly L. Brown Tags: Case Report Source Type: research

Biomarkers associating endothelial Dysregulation in pediatric-onset systemic lupus erythematous
Endothelium is a key element in the regulation of vascular homeostasis and its alteration can lead to the development of vascular diseases. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease w... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - October 24, 2019 Category: Rheumatology Authors: Wan-Fang Lee, Chao-Yi Wu, Huang-Yu Yang, Wen-I Lee, Li-Chen Chen, Liang-Shiou Ou and Jing-Long Huang Tags: Research article Source Type: research

Infrared thermography in children: a reliable tool for differential diagnosis of peripheral microvascular dysfunction and Raynaud ’s phenomenon?
Infrared Thermography (IRT) has been used for over 30  years in the assessment of Raynaud Phenomenon (RP) and other peripheral microvascular dysfunctions in adults but, to date, very little experience is availa... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - October 16, 2019 Category: Rheumatology Authors: Giorgia Martini, Michela Cappella, Roberta Culpo, Fabio Vittadello, Monica Sprocati and Francesco Zulian Tags: Research article Source Type: research

Same but different? A thematic analysis on adalimumab biosimilar switching among patients with juvenile idiopathic arthritis
Biologic medications have dramatically enhanced the treatment of many chronic paediatric inflammatory conditions. Their high cost is a factor that prohibits their broader use. Cheaper generic versions, or bios... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - October 4, 2019 Category: Rheumatology Authors: William D. Renton, Helen Leveret, Catherine Guly, Heather Smee, Jamie Leveret and Athimalaipet V. Ramanan Tags: Research article Source Type: research

Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC)
JIA-associated uveitis (JIAU) is a serious, sight-threatening disease with significant long-term complications and risk of blindness, even with improved contemporary treatments. The MIWGUC was set up in order ... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - October 1, 2019 Category: Rheumatology Authors: Ivan Foeldvari, Jens Klotsche, Gabriele Simonini, Clive Edelsten, Sheila T. Angeles-Han, Regitze Bangsgaard, Joke de Boer, Gabriele Brumm, Rosa Bou Torrent, Tamas Constantin, Cinzia DeLibero, Jesus Diaz, Valeria Maria Gerloni, Margarida Guedes, Arnd Heili Tags: Research article Source Type: research

The role of age-specific N-terminal pro-brain natriuretic peptide cutoff values in predicting intravenous immunoglobulin resistance in Kawasaki disease: a prospective cohort study
The prediction of resistance to intravenous immunoglobulins (IVIG) is currently still one of the main research areas in Kawasaki disease (KD). Several studies have reported on the use of N-terminal pro-brain n... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - September 18, 2019 Category: Rheumatology Authors: Shuran Shao, Chunyan Luo, Kaiyu Zhou, Yimin Hua, Mei Wu, Lei Liu, Xiaoliang Liu and Chuan Wang Tags: Research article Source Type: research

Reduction in the utilization of prednisone or methotrexate in Canadian claims data following initiation of etanercept in pediatric patients with juvenile idiopathic arthritis
In adult patients with arthritis, use of the tumor necrosis factor (TNF) inhibitor etanercept (ETN) is often associated with a reduction in the utilization of co-medications, particularly steroids. Comparative... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - September 10, 2019 Category: Rheumatology Authors: Majed Khraishi, Brad Millson, John Woolcott, Heather Jones, Lisa Marshall and Nicolino Ruperto Tags: Research article Source Type: research

Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis: a longitudinal study of the Nordic JIA cohort
To determine the serum levels of the lectin pathway proteins early in the disease course and 17  years after disease onset and to correlate the protein levels to markers of disease activity in participants from... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - September 9, 2019 Category: Rheumatology Authors: Mia Glerup, Steffen Thiel, Veronika Rypdal, Ellen Dalen Arnstad, Maria Ekelund, Suvi Peltoniemi, Kristiina Aalto, Marite Rygg, Susan Nielsen, Anders Fasth, Lillemor Berntson, Ellen Nordal and Troels Herlin Tags: Research article Source Type: research

No radiographic wrist damage after treatment to target in recent-onset juvenile idiopathic arthritis
To evaluate radiographic progression of patients with new-onset juvenile idiopathic arthritis (JIA) in response to an early, tightly-controlled, treatment-to-target. (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - September 4, 2019 Category: Rheumatology Authors: P. C. E. Hissink Muller, W. G. van Braak, D. Schreurs, C. M. Nusman, S. A. Bergstra, R. Hemke, D. Schonenberg-Meinema, J. M. van den Berg, T. W. Kuijpers, Y. Koopman-Keemink, M. A. J. van Rossum, L. W. A. van Suijlekom-Smit, D. M. C. Brinkman, C. F. Allaa Tags: Research article Source Type: research

Rituximab-associated Hypogammaglobulinemia in pediatric patients with autoimmune diseases
Despite the increased use of rituximab in treating pediatric patients with autoimmune diseases in the last decade, there are limited data on rituximab safety in those subjects who have a developing immune syst... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - August 28, 2019 Category: Rheumatology Authors: Amer M. Khojah, Michael L. Miller, Marisa S. Klein-Gitelman, Megan L. Curran, Victoria Hans, Lauren M. Pachman and Ramsay L. Fuleihan Tags: Research article Source Type: research

An unprecedented COPA gene mutation in two patients in the same family: comparative clinical analysis of newly reported patients with other known COPA gene mutations
The COPA syndrome is a newly recognized monogenic, autosomal dominant autoimmune disease presenting mostly presenting in childhood. Clinical features include inflammation of the lungs, kidneys, and joints. App... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - August 27, 2019 Category: Rheumatology Authors: Anjali Patwardhan and Charles H. Spencer Tags: Review Source Type: research

The pain trajectory of juvenile idiopathic arthritis (JIA): translating from adolescent patient report to behavioural sensitivity in a juvenile animal model
While pain is a common symptom in JIA patients, it remains unclear why some JIA patients develop ongoing or persistent pain. Complex clinical and social settings confound analysis of individual factors that ma... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - August 27, 2019 Category: Rheumatology Authors: Annastazia E. Learoyd, Debajit Sen and Maria Fitzgerald Tags: Research article Source Type: research

Enthesitis-related arthritis is the most common category of juvenile idiopathic arthritis in Taiwan and presents persistent active disease
Juvenile idiopathic arthritis (JIA) has been categorized into seven different categories according to the International League of Associations for Rheumatology (ILAR) criteria. Enthesitis-related arthritis (ER... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - August 23, 2019 Category: Rheumatology Authors: Yang-Jen Shih, Yao-Hsu Yang, Chun-Ying Lin, Chia-Ling Chang and Bor-Luen Chiang Tags: Research article Source Type: research

Intravenous dosing of tocilizumab in patients younger than two years of age with systemic juvenile idiopathic arthritis: results from an open-label phase 1 clinical trial
The anti –interleukin-6 receptor-alpha antibody tocilizumab was approved for intravenous (IV) injection in the treatment of patients with systemic juvenile idiopathic arthritis (sJIA) aged 2 to 17 years based o... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - August 22, 2019 Category: Rheumatology Authors: Navita L. Mallalieu, Sunethra Wimalasundera, Joy C. Hsu, Wendy Douglass, Chris Wells, Inmaculada Calvo Penades, Ruben Cuttica, Hans-Iko Huppertz, Rik Joos, Yukiko Kimura, Diana Milojevic, Margalit Rosenkranz, Kenneth Schikler, Tamas Constantin and Carine Tags: Research article Source Type: research

Biologics in refractory myositis: experience in juvenile vs. adult myositis; part II: emerging biologic and other therapies on the horizon
The idiopathic inflammatory myopathies (IIM) until recently have been considered a heterogeneous broad group of six autoimmune muscle diseases. Initially, autoantibodies in IIM (including JDM) and CD8+ T cell-... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - August 20, 2019 Category: Rheumatology Authors: Anjali Patwardhan and Charles H. Spencer Tags: Review Source Type: research

RAS-associated Autoimmune Leukoproliferative disease (RALD) manifested with early-onset SLE-like syndrome: a case series of RALD in Chinese children
Primary immunodeficiency diseases (PIDs) patients may show systemic lupus erythematosus (SLE)-like autoimmunity disorders, such as cytopenias, as well as polyarthritis, which leads to concerns of misdiagnosis.... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - August 14, 2019 Category: Rheumatology Authors: Wei Wang, Yu Zhou, Linqing Zhong, Lin Wang, Xiaoyan Tang, Mingsheng Ma, Ji Li and Hongmei Song Tags: Research article Source Type: research

A UK study: vocational experiences of young adults with juvenile idiopathic arthritis
(Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - August 6, 2019 Category: Rheumatology Authors: Laura E. Lunt, Ailsa Bosworth, Matthew Bezzant, Karen Walker-Bone, Kimme L. Hyrich, Wendy Thomson, Janet E. McDonagh and Suzanne M. M. Verstappen Tags: Letter to the Editor Source Type: research

The time option of IVIG treatment is associated with therapeutic responsiveness and coronary artery abnormalities but not with clinical classification in the acute episode of Kawasaki disease
In the last decade, incomplete Kawasaki disease (KD), intravenous immunoglobulin (IVIG) non-response and coronary artery abnormalities (CAA) have experienced the increasing trends in China. In addition, the en... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 31, 2019 Category: Rheumatology Authors: Sama Samadli, Fei Fei Liu, Goshgar Mammadov, Jing Jing Wang, Hui Hui Liu, Yang Fang Wu, Huang Huang Luo, Yue Wu, Wei Xia Chen, Dong Dong Zhang, Wei Wei and Peng Hu Tags: Research article Source Type: research

Whole exome sequencing in childhood-onset lupus frequently detects single gene etiologies
Systemic lupus erythematosus (SLE) comprise a diverse range of clinical manifestations. To date, more than 30 single gene causes of lupus/lupus like syndromes in humans have been identified. In the clinical se... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 30, 2019 Category: Rheumatology Authors: Irit Tirosh, Shiri Spielman, Ortal Barel, Reut Ram, Tali Stauber, Gideon Paret, Marina Rubinsthein, Itai M. Pessach, Maya Gerstein, Yair Anikster, Rachel Shukrun, Adi Dagan, Katerina Adler, Ben Pode-Shakked, Alexander Volkov, Marina Perelman & hellip; Tags: Research article Source Type: research

Demographic, clinical, and treatment characteristics of the juvenile primary fibromyalgia syndrome cohort enrolled in the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry
To describe the demographic, clinical, and treatment characteristics of youth diagnosed with juvenile primary fibromyalgia syndrome (JPFS) who are seen in pediatric rheumatology clinics. (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 26, 2019 Category: Rheumatology Authors: Jenifer E. Weiss, Kenneth N. Schikler, Alexis D. Boneparth and Mark Connelly Tags: Research article Source Type: research

A prediction rule for lack of achievement of inactive disease with methotrexate as the sole disease-modifying antirheumatic therapy in juvenile idiopathic arthritis
To investigate the frequency of achievement of inactive disease (ID) in children with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX) as the sole disease-modifyng antirheumatic (DMARD) ther... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 25, 2019 Category: Rheumatology Authors: Cecilia Bava, Federica Mongelli, Angela Pistorio, Marta Bertamino, Giulia Bracciolini, Sara Dalpr à, Sergio Davì, Stefano Lanni, Valentina Muratore, Silvia Pederzoli, Silvia Rosina, Benedetta Schiappapietra, Chiara Suffia, Giulia Varnier, Sara Verazza, Tags: Research article Source Type: research

Chronic non-bacterial osteomyelitis: a comparative study between children and adults
To compare clinical presentation, diagnostic and treatment strategies, and outcome between pediatric and adult patients with chronic non-bacterial osteomyelitis (CNO). (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 23, 2019 Category: Rheumatology Authors: Andrea Skrabl-Baumgartner, Peter Singer, Theresa Greimel, Gregor Gorkiewicz and Josef Hermann Tags: Research article Source Type: research

TNF blockade contributes to restore lipid oxidation during exercise in children with juvenile idiopathic arthritis
Children with juvenile idiopathic arthritis (JIA) have impaired physical abilities. TNF- α plays a crucial role in this pathogenesis, but it is also involved in the use of lipids and muscle health. Objective of... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 22, 2019 Category: Rheumatology Authors: Emmanuelle Rochette, Pierre Bourdier, Bruno Pereira, Eric Dor é, Anthony Birat, Sébastien Ratel, Stéphane Echaubard, Pascale Duché and Etienne Merlin Tags: Research article Source Type: research

Physician practices for withdrawal of medications in inactive systemic juvenile arthritis, Childhood Arthritis and Rheumatology Research Alliance (CARRA) survey
We describe a Childhood Arthritis and Rheumatology Research Alliance (CARRA) survey of North American pediatric rheumatologists that assesses physician attitudes on withdrawal of medications in systemic juveni... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 22, 2019 Category: Rheumatology Authors: Susan Shenoi, Kabita Nanda, Grant S. Schulert, John F. Bohnsack, Ashley M. Cooper, Bridget Edghill, Miriah C. Gillispie-Taylor, Baruch Goldberg, Olha Halyabar, Thomas G. Mason, Tova Ronis, Rayfel Schneider, Richard K. Vehe and Karen Onel Tags: Research article Source Type: research

Association between maternal age and outcomes in Kawasaki disease patients
This study was aim to survey the perinatal factors and clinical outcome of KD, including coronary arter... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 19, 2019 Category: Rheumatology Authors: Wei-Dong Huang, Yu-Ting Lin, Zi-Yu Tsai, Ling-Sai Chang, Shih-Feng Liu, Yi-Ju Lin and Ho-Chang Kuo Tags: Research article Source Type: research

Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis
Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system of yet unknown etiology. Patients present with local bone pain and inflammation and - to our experience - often ... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 18, 2019 Category: Rheumatology Authors: Nentwich Julia, Ruf Katharina, Girschick Hermann, Holl-Wieden Annette, Morbach Henner, Hebestreit Helge and Hofmann Christine Tags: Research article Source Type: research

Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study
We designed and initiated a pilot comparative effectiveness study for juvenile localized scleroderma (jLS), for which there is limited evidence on best therapy. We evaluated the process we used, in relation to... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 15, 2019 Category: Rheumatology Authors: Suzanne C. Li, Robert C. Fuhlbrigge, Ronald M. Laxer, Elena Pope, Maria F. Ibarra, Katie Stewart, Thomas Mason II, Mara L. Becker, Sandy Hong, Fatma Dedeoglu, Kathryn S. Torok, C. Egla Rabinovich, Polly J. Ferguson, Marilynn Punaro, Brian M. Feldman, Trac Tags: Research article Source Type: research

Participation in school and physical education in juvenile idiopathic arthritis in a Nordic long-term cohort study
The aim of the study was to describe school attendance and participation in physical education in school among children with juvenile idiopathic arthritis (JIA). (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 15, 2019 Category: Rheumatology Authors: Ellen Nordal, Veronika Rypdal, Ellen Dalen Arnstad, Kristiina Aalto, Lillemor Berntson, Maria Ekelund, Anders Fasth, Mia Glerup, Troels Herlin, Susan Nielsen, Suvi Peltoniemi, Marek Zak, Nils Thomas Songstad and Marite Rygg Tags: Research article Source Type: research

Plasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells
The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and under-investigated. We have hyp... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 12, 2019 Category: Rheumatology Authors: Kaiyu Jiang, Rie Karasawa, Zihua Hu, Yanmin Chen, Lucy Holmes, Kathleen M. O ’Neil and James N. Jarvis Tags: Research article Source Type: research

Retrospective review of immobilization vs. immediate resumption of activity in patients with Oligoarticular juvenile idiopathic arthritis following knee injections
Intraarticular corticosteroid injection (IACI) is one of the most common treatments in oligoarticular Juvenile Idiopathic Arthritis (JIA). Activity recommendations following injection vary, as there are no pub... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 12, 2019 Category: Rheumatology Authors: Elaine R. Flanagan, Heather Benham, Janet Figueroa, Janille Diaz, Jenna Tress and David D. Sherry Tags: Research article Source Type: research

Defining outcome measures in juvenile idiopathic arthritis associated uveitis by a systematic review analysis: do we need a consensus?
Juvenile Idiopathic Arthritis associated Uveitis (JIA-U) represents its most frequent extra-articular manifestation and the main cause of childhood uveitis in in developed countries. The broad variety of outco... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 11, 2019 Category: Rheumatology Authors: Greta Mastrangelo, Ivan Foeldvari, Jordi Anton and Gabriele Simonini Tags: Review Source Type: research

Testicular ischemia in deficiency of adenosine deaminase 2 (DADA2)
Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive autoinflammatory condition. Recognised features include vasculitis predominantly affecting medium sized vessels, livedoid skin rash, ce... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 10, 2019 Category: Rheumatology Authors: Katherine Clarke, Cathy Campbell, Ebun Omoyinmi, Ying Hong, Muthana Al Obaidi, Neil Sebire and Paul A. Brogan Tags: Case Report Source Type: research

Retrospective case series describing the efficacy, safety and cost-effectiveness of a vial-sharing programme for canakinumab treatment for paediatric patients with cryopyrin-associated periodic syndrome
Cryopyrin-associated periodic syndrome (CAPS) is a rare autoinflammatory disease, caused by gain of function mutation in NLRP3 resulting in excess production of interleukin-1 (IL-1). Canakinumab is a human monocl... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 8, 2019 Category: Rheumatology Authors: Abdulkadir A. Elmi, Karen Wynne, Iek L. Cheng, Despina Eleftheriou, Helen J. Lachmann, Philip N. Hawkins and Paul Brogan Tags: Research article Source Type: research

Scoping review of biological treatment of deficiency of interleukin-36 receptor antagonist (DITRA) in children and adolescents
Deficiency of interleukin-36 receptor antagonist (DITRA) is a life threatening monogenic autoinflammatory disease caused by loss of function mutations in the IL36RN gene. Affected patients develop recurrent episo... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 8, 2019 Category: Rheumatology Authors: Toni Hospach, Fabian Glowatzki, Friederike Blankenburg, Dennis Conzelmann, Christian Stirnkorb, Chris Sandra M üllerschön, Peter von den Driesch, Lisa Maria Köhler, Meino Rohlfs, Christoph Klein and Fabian Hauck Tags: Review Source Type: research

Whole exome sequencing approach to childhood onset familial erythrodermic psoriasis unravels a novel mutation of CARD14 requiring unusual high doses of ustekinumab
Autosomal dominant gain of function mutations in caspase recruitment domain family member 14 (CARD14) is a rare condition associated with plaque-type psoriasis, generalized pustular psoriasis, palmoplantar pus... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 8, 2019 Category: Rheumatology Authors: S. Signa, E. Campione, M. Rusmini, S. Chiesa, A. Grossi, A. Omenetti, R. Caorsi, G. M. Viglizzo, M. Galluzzo, L. Bianchi, M. Talamonti, A. Orlandi, A. Martini, I. Ceccherini and M. Gattorno Tags: Case Report Source Type: research

Efficacy of pamidronate in children with chronic non-bacterial osteitis using whole body MRI as a marker of disease activity
To study the response to pamidronate using whole body magnetic resonance imaging (WB-MRI) in children with chronic non-bacterial osteitis (CNO) in a tertiary health centre. (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 4, 2019 Category: Rheumatology Authors: C. S. Bhat, M. Roderick, E. S. Sen, A. Finn and A. V. Ramanan Tags: Research article Source Type: research

A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease
Kawasaki disease (KD) is a systemic vasculitis which may be associated with coronary artery aneurysms. A notable risk factor for the development of coronary artery aneurysms is resistance to intravenous immuno... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 3, 2019 Category: Rheumatology Authors: Yuji Amano, Yohei Akazawa, Jun Yasuda, Kazuhisa Yoshino, Katsuhiko Kojima, Norimoto Kobayashi, Satoshi Matsuzaki, Masao Nagasaki, Yosuke Kawai, Naoko Minegishi, Noriko Ishida, Noriko Motoki, Akira Hachiya, Yozo Nakazawa, Masayuki Yamamoto, Kenichi Koike & Tags: Research article Source Type: research

Heavy metals in fish and its association with autoimmunity in the development of juvenile idiopathic arthritis: a prospective birth cohort study
The etiology of Juvenile Idiopathic Arthritis (JIA) is poorly understood. The purpose of this study was to examine the possible influence of early nutrition on later development of JIA. (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 2, 2019 Category: Rheumatology Authors: Erik Kindgren, Carlos Guerrero-Bosagna and Johnny Ludvigsson Tags: Research article Source Type: research

Research priorities in childhood-onset lupus: results of a multidisciplinary prioritization exercise
Childhood-onset systemic erythematosus lupus (cSLE) is characterized by more severe disease, widespread organ involvement and higher mortality compared to adult-onset SLE. However, cSLE is largely underfunded ... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - July 1, 2019 Category: Rheumatology Authors: Stacy P. Ardoin, R Paola Daly, Lyna Merzoug, Karin Tse, Kaveh Ardalan, Lisa Arkin, Andrea Knight, Tamar Rubinstein, Natasha Ruth, Scott E. Wenderfer and Aimee O. Hersh Tags: Research article Source Type: research

Hallmark trials in ANCA-associated vasculitis (AAV) for the pediatric rheumatologist
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) refers to a complex group of systemic vasculitides that are characterized by primary small-to-medium sized blood vessel inflammation with... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - June 26, 2019 Category: Rheumatology Authors: Jennifer J. Y. Lee, Alhanouf Alsaleem, Grace P. K. Chiang, Elizaveta Limenis, Watchareewan Sontichai, Rae S. M. Yeung, Jonathan Akikusa and Ronald M. Laxer Tags: Review Source Type: research

Being on the juvenile dermatomyositis rollercoaster: a qualitative study
Juvenile Dermatomyositis is a rare, potentially life-threatening condition with no known cure. There is no published literature capturing how children and young people feel about their condition, from their pe... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - June 18, 2019 Category: Rheumatology Authors: Polly Livermore, Suzanne Gray, Kathleen Mulligan, Jennifer N. Stinson, Lucy R. Wedderburn and Faith Gibson Tags: Research article Source Type: research

Early administration of adalimumab for paediatric uveitis due to Beh çet’s disease
Beh çet’s disease is a chronic inflammatory multisystem disorder that is characterised by oral and/or genital ulcerations as well as intraocular inflammation. Recurrent retinal vasoocclusive episodes and macula... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - June 10, 2019 Category: Rheumatology Authors: Tomona Hiyama, Yosuke Harada, Takehiko Doi and Yoshiaki Kiuchi Tags: Case Report Source Type: research

Relapsing periodic arthritis, palindromic rheumatism and MEFV gene-related variants alleles in children
Relapsing periodic arthritis is a general term used for a group of diseases with recurring and periodic nature, in which the joints are intermittently involved. The aim of this study is to evaluation of the po... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - June 6, 2019 Category: Rheumatology Authors: Farhad Salehzadeh, Manuchehr Barak and Roghayeh Nematdoust Haghi Tags: Research article Source Type: research

A delayed diagnosis of eosinophilic granulomatosis with polyangiitis complicated with extensive artery occlusion of lower extremities in children: case report and literature review
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis in children. A delayed or missed diagnosis of pediatric EGPA is common, owing to the atypical clinical manifestation and limit... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - May 28, 2019 Category: Rheumatology Authors: Xiaoliang Liu, Lin Wang, Kaiyu Zhou, Yimin Hua, Xiaoqing Shi and Chuan Wang Tags: Case Report Source Type: research

Efficacy and safety of duloxetine versus placebo in adolescents with juvenile fibromyalgia: results from a randomized controlled trial
Currently, there are no medications approved for the treatment of juvenile fibromyalgia (JFM). We evaluated the safety and efficacy of duloxetine 30/60  mg once daily (QD) versus placebo in adolescents with JFM. (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - May 28, 2019 Category: Rheumatology Authors: Himanshu P. Upadhyaya, Lesley M. Arnold, Karla Alaka, Meihua Qiao, David Williams and Renata Mehta Tags: Research article Source Type: research

The PRINTO evidence-based proposal for glucocorticoids tapering/discontinuation in new onset juvenile dermatomyositis patients
Prednisone (PDN) in juvenile dermatomyositis (JDM), alone or in association with other immunosuppressive drugs, namely methotrexate (MTX) and cyclosporine (CSA), represents the first-line treatment option for ... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - May 22, 2019 Category: Rheumatology Authors: Gabriella Giancane, Claudio Lavarello, Angela Pistorio, Sheila K. Oliveira, Francesco Zulian, Ruben Cuttica, Michel Fischbach, Bo Magnusson, Serena Pastore, Roberto Marini, Silvana Martino, Anne Pagnier, Christine Soler, Valda Sta ņēvicha, Rebecca Ten C Tags: Research article Source Type: research

An unusual presentation of purine nucleoside phosphorylase deficiency mimicking systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory condition that presents with fever, rash and arthritis. At onset systemic features are predominant and the diagnosis may be a challenge. Seconda... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - May 22, 2019 Category: Rheumatology Authors: Alessia Arduini, Emiliano Marasco, Giulia Marucci, Manuela Pardeo, Antonella Insalaco, Ivan Caiello, Gian Marco Moneta, Giusi Prencipe, Fabrizio De Benedetti and Claudia Bracaglia Tags: Short Report Source Type: research

Development of a benchmarking toolkit for adolescent and young adult rheumatology services (BeTAR)
Young people (YP; 12 –24 years old) with rheumatic diseases face many challenges associated with chronic illness in addition to the physiological and psychosocial changes of adolescence. Timely access to develo... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - May 21, 2019 Category: Rheumatology Authors: Ran A. Cai, Hema Chaplin, Polly Livermore, Martin Lee, Debajit Sen, Lucy R. Wedderburn, Nick Wilkinson, Rachel Jeffery, Andrea Kempa, Imogen Norton, Rachel Tattersall, Yiannis Ioannou and Despina Eleftheriou Tags: Research article Source Type: research