Effects of supplementary Da Dingfeng Zhu therapy on patients with Parkinson's disease of liver-kidney yin deficiency pattern
This study aimed to verify whether the combined use of Da Dingfengzhu and Western medicine in treating Parkinson's disease (PD) can lead to therapeutic efficacy and symptom alleviation, thereby achieving a complementary and synergistic effect. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 17, 2024 Category: Neurology Authors: Meili Liu, Zhiwei Jia, Tianyu Yao, Guoxian Zhang, Xuejing Wang Source Type: research

Differential influences of rest tremor on brain fiber architecture in essential tremor and Parkinson's disease
Rest tremor is a movement disorder commonly found in diseases like Parkinson's disease (PD) and essential tremor (ET). Rest tremor typically shows slower progression in PD, but more severe progression in ET. However, the underlying white matter organization of rest tremor behind PD and ET remains unclear. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 15, 2024 Category: Neurology Authors: Xiaojie Duanmu, Jiaqi Wen, Jianmei Qin, Sijia Tan, Chenqing Wu, Weijin Yuan, Qianshi Zheng, Cheng Zhou, Haoting Wu, Jingwen Chen, Shuyue Wang, Hui Hong, Tao Guo, Jingjing Wu, Bingting Zhu, Yuelin Fang, Yaping Yan, Guohua Zhao, Baorong Zhang, Minming Zhang Source Type: research

Brain-first vs. body-first Parkinson's disease: An update on recent evidence
We recently proposed a new disease model of Parkinson's disease – the a-Synuclein Origin site and Connectome model. The model posits that the initial pathology starts either in the olfactory bulb or amygdala leading to a brain-first subtype, or in the enteric nervous system leading to a body-first subtype. These subtypes should be distinguishable early in the disease course on a range of imaging, clinical, and neuropathological markers. Here, we review recent original human studies, which tested the predictions of the model.Molecular imaging studies were generally in agreement with the model, whereas structural imaging s...
Source: Parkinsonism and Related Disorders - March 15, 2024 Category: Neurology Authors: Jacob Horsager, Per Borghammer Tags: Review article Source Type: research

MRI index of glymphatic system mediates the influence of locus coeruleus on cognition in Parkinson's disease
The objective was to investigate the relationship among LC degeneration, cognitive performance, and the glymphatic function in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 15, 2024 Category: Neurology Authors: Xinhui Wang, Pei Huang, Ewart Mark Haacke, Peng Wu, Xiaobing Zhang, Huihui Zhang, Zenghui Cheng, Rongbiao Tang, Fangtao Liu, Yu Liu, Xiaofeng Shi, Peng Liu, Youmin Zhang, Zhijia Jin, Shengdi Chen, Naying He, Fuhua Yan Tags: Short communication Source Type: research

The role of peripheral inflammation-related biomarkers in distinguishing Parkinson's disease
Peripheral inflammation plays a significant role in Parkinson's disease (PD). Conflicting studies on whether inflammatory indicators in blood could serve as biomarkers to distinguish PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 14, 2024 Category: Neurology Authors: Zhuo Zhang, Yue Wang, Jin Wang, Ying Cai, Peipei Liu, Shoufeng Liu, Jialing Wu, Xin Xie Source Type: research

Updates in essential tremor
Essential tremor (ET) is one of the most common tremor disorders and can be disabling in its affect on daily activities. There have been major breakthroughs in the treatment of tremor and ET is the subject of important ongoing research. This review will present recent advancements in the epidemiology, genetics, pathophysiology, diagnosis, comorbidities, and imaging of ET. Current and future treatment options in the management of ET will also be reviewed. The need for continued innovation and scientific inquiry to meet the unmet needs of persons of ET will be highlighted. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 12, 2024 Category: Neurology Authors: Tyler Okelberry, Kelly E. Lyons, Rajesh Pahwa Tags: Review article Source Type: research

OFF episode quality of life impact scale (OFFELIA): A new measure of quality of life for off episodes in Parkinson's disease
OFF Episodes occur in people with Parkinson's disease when their medication wears off, and motor and/or non-motor symptoms emerge. Existing measures used to assess OFF Episodes focus on the time spent in OFF Episodes through diaries or by identifying symptoms, but they are limited in their ability to capture the severity and functional impact of OFF episodes. The aim of this study was to develop and validate a new instrument, called “OFFELIA,” that measures the impact of OFF episodes on the quality of life of individuals with Parkinson's disease. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 12, 2024 Category: Neurology Authors: Maja Kuharic, Victoria Kulbokas, Kent Hanson, Jonathan L. Nazari, Kanya K. Shah, Ai Nguyen, Tara Hensle, Connie Marras, Melissa J. Armstrong, Yash J. Jalundhwala, A. Simon Pickard Source Type: research

Importance of upper and lower body resistance exercise for preventing and reversing sarcopenia in Parkinson ’s disease
The conclusion of the abstract of Kim et al. suggests that High Intensity Interval Training (HIIT) may be superior to Moderate Intensity Continuous Training (MICT) in improving “sarcopenia” in people with Parkinson’s Disease (PwPD) [1]. These findings are potentially important since they show preliminary evidence that HIIT can improve parameters related to “sarcopenia”. However, it is important to note to note that the authors do not directly compare the experime ntal two groups. The HIIT group was only directly compared to the usual care group and did show greater increases in leg lean mass, Appendicular Skeleta...
Source: Parkinsonism and Related Disorders - March 12, 2024 Category: Neurology Authors: Daniel M. Corcos Source Type: research

Deep brain stimulation of the subthalamic nucleus increases the risk of sialorrhea in patients with advanced Parkinson's disease
Sialorrhea is a common neurological manifestation of Parkinson's disease (PD). No specifically designed prospective study has tested the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) on sialorrhea in patients with advanced PD. We focused on the effect of STN-DBS on the incidence of sialorrhea in patients with PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 8, 2024 Category: Neurology Authors: Jinxing Sun, Lian Cheng, Li Zhenke, Junheng Jia, Qianqian Wu, Ying Hou, Qi Wang, Guangjian Zhang, Hong Wang, Xingang Li, Weiguo Li, Chao Zhang Source Type: research

Correlation between clinical and neuropathological subtypes of progressive supranuclear palsy
This study aimed to statistically verify the correspondence between the clinical and pathological subtypes of PSP. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 8, 2024 Category: Neurology Authors: Ryuichi Koizumi, Akagi Akio, Yuichi Riku, Hiroaki Miyahara, Jun Sone, Fumiaki Tanaka, Mari Yoshida, Yasushi Iwasaki Source Type: research

Anti-alpha synuclein and anti-tau immunotherapies: Can a cocktail approach work?
The hypothesis that neurodegenerative diseases are proteinopathies due to toxic effect of different underlying proteins, such as amyloid-beta and 3+4R-tau in Alzheimer's disease (AD) and alpha-synuclein in Parkinson's disease (PD), while still controversial is supported by several studies in the literature. This has led to conduct clinical trials attempting to reduce the load of these allegedly toxic proteins by immunotherapy, mostly but not solely based on antibodies against these proteins. Already completed clinical trials have ranged from initially negative results to recently partial positive outcomes, specifically for...
Source: Parkinsonism and Related Disorders - March 7, 2024 Category: Neurology Authors: Kirsys Patricia del Giudice, Marina Cosgaya, Idoia Zaro, Valeria Ravasi, Pilar Santacruz, Celia Painous, Manel Fern ández, Ana Cámara, Yaroslau Compta Tags: Review article Source Type: research

Bilateral primary motor area intermittent theta-burst stimulation may alleviate gait and postural disturbances in Parkinson's disease patients by astrocytic modulation, caudate volume changes, and increased functional neuroplasticity
Axial signs, such as gait disturbances and postural abnormalities, are common symptoms in advanced Parkinson's disease (PD). Postural instability is closely linked with both gait and balance dysfunction, and these conditions are directly related to the risk of falls. Compared to dyskinesia and motor complications, gait and postural dysfunctions are some of the most disabling symptoms for individuals with PD and are a major contributor to loss of autonomy and diminished quality of life. In addition, debilitating axial symptoms are common as the condition progresses, result in a substantial reduction in the therapeutic respo...
Source: Parkinsonism and Related Disorders - March 6, 2024 Category: Neurology Authors: Ra úl Rashid-López, Paloma Macías-García, Álvaro J. Cruz-Gómez, Francisco L. Sánchez-Fernández, Fátima Cano-Cano, Florencia Sanmartino, Esteban Sarrias-Arrabal, Elena Lozano-Soto, Constantino Méndez-Bértolo, Fernando López-Sosa, Álvaro Gonzá Tags: Correspondence Source Type: research

Real-world local field potential recordings in patients with deep brain stimulation for Parkinson's disease
Deep brain stimulation (DBS) advances enable the recording of local field potentials (LFP) in real-world settings. LFP recordings from the subthalamic nucleus (STN) and globus pallidus internus (GPi) in people with Parkinson's disease (PwPD) have illuminated the role of oscillatory synchronization in parkinsonian motor symptoms [1,2]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 5, 2024 Category: Neurology Authors: Alfonso Fasano, Hideo Mure, Sarah Kathleen Bick, Mya Schiess, Thomas Witt, Katsuo Kimura, Alexa Singer, Claudia Sannelli, Nathan Morelli, Genko Oyama, PSR Study Group Tags: Correspondence Source Type: research

Towards a biological diagnosis of PD
Since the original description by James Parkinson, Parkinson's disease (PD) has intrigued us for over 200 years. PD is a progressive condition that is incurable so far, and affects millions of people worldwide. Over the years, our knowledge has expanded tremendously, and a range of criteria have been put forward and used to try to define PD. However, owing to the complexity of the problem, it is still not consensual how to diagnose and classify a disease that manifests with diverse features, and that responds differently to existing therapies and to those under development. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 5, 2024 Category: Neurology Authors: Avika Chopra, Anthony E. Lang, G ünter Höglinger, Tiago F. Outeiro Tags: Review article Source Type: research

Physiological effects of dual target DBS in an individual with Parkinson's disease and a sensing-enabled pulse generator
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus (GP) is an established therapy for Parkinson's disease (PD). Novel DBS devices can record local field potential (LFP) physiomarkers from the STN or GP. While beta (13 –30 Hz) and gamma (40–90 Hz) STN and GP LFP oscillations correlate with PD motor severity and with therapeutic effects of treatments, STN-GP interactions in electrophysiology in patients with PD are not well characterized. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 5, 2024 Category: Neurology Authors: Daniel D. Cummins, Stephanie S. Sandoval-Pistorius, Stephanie Cernera, Rodrigo Fernandez-Gajardo, Lauren Hammer, Philip A. Starr Tags: Short communication Source Type: research