Understanding cognitive changes in patients with Parkinson's disease using novel fiber quantification techniques
Beyond the cardinal motor symptoms, cognitive impairment emerges as a significant non-motor symptom, affecting approximately 30 –40% of individuals with Parkinson's disease (PD) during its initial stages. As the disease advances, the majority—up to 80%—will develop cognitive impairment, potentially leading to dementia [1,2]. Research findings suggest that the changes in white matter (WM) structure could serve as a valu able biomarker in the early stages of PD [3]. This potential is underscored by the ability of diffusion tensor imaging (DTI) to identify degenerations within WM that are correlated with cognitive impai...
Source: Parkinsonism and Related Disorders - September 13, 2023 Category: Neurology Authors: Anupa A. Vijayakumari, Virendra R. Mishra Source Type: research

Understanding Cognitive Changes in Patients with Parkinson ’s Disease Using Novel Fiber Quantification Techniques
Beyond the cardinal motor symptoms, cognitive impairment emerges as a significant non-motor symptom, affecting approximately 30-40% of individuals with Parkinson's disease (PD) during its initial stages. As the disease advances, the majority —up to 80%—will develop cognitive impairment, potentially leading to dementia [1, 2]. Research findings suggest that the changes in white matter (WM) structure could serve as a valuable biomarker in the early stages of PD [3]. This potential is underscored by the ability of diffusion tensor imag ing (DTI) to identify degenerations within WM that are correlated with cognitive impair...
Source: Parkinsonism and Related Disorders - September 13, 2023 Category: Neurology Authors: Anupa A. Vijayakumari, Virendra R. Mishra Source Type: research

Genetic literacy and attitude towards genetic testing in patients with Parkinson's disease and their caregivers: A review of literature
Genetic literacy refers to an individual's ability to understand the basics of genetic concepts and apply them to health-related decisions. The level of genetic literacy influences attitude towards genetic testing and is, in turn, influenced by several other factors. Clinicians must be aware of the genetic literacy of their patients and their caregivers before advising genetic testing and/or undertaking pre and post-test counseling. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 12, 2023 Category: Neurology Authors: Sneha D. Kamath, Vikram V. Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal Tags: Review article Source Type: research

Nigrostriatal dysfunction in RFC1-related disorder/CANVAS
Parkinsonism is now recognized as an additional feature in RFC1/CANVAS syndrome; however, no systematic evaluation of nigrostriatal dopaminergic function has been published so far. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 12, 2023 Category: Neurology Authors: Maria Paula C. Azevedo, Camila C. Lobo, Gabriel S. Schmitt, Paula C.A.A.P. Matos, Orlando G.P. Barsottini, Jos é Luiz Pedroso, Wilson Marques, Juliana Pasquotto Souza, Bárbara J. Amorim, Marcondes C. França Tags: Short communication Source Type: research

MRgFUS of the nucleus ventralis intermedius in essential tremor modulates functional connectivity within the classical tremor network and beyond
Magnetic resonance-guided focused ultrasound (MRgFUS) of the thalamic ventral intermediate nucleus is an incisionless lesional treatment for essential tremor. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 11, 2023 Category: Neurology Authors: Christine Kindler, Neeraj Upadhyay, Veronika Purrer, Frederic Carsten Schmeel, Valeri Borger, Lukas Scheef, Ullrich W üllner, Henning Boecker Source Type: research

Do cerebrovascular risk factors impact the clinical expression of idiopathic isolated adult-onset dystonia?
Although acquired dystonia may develop following ischaemic/haemorrhagic stroke, the relationship between cerebrovascular disease and idiopathic dystonia has been poorly investigated. This cross sectional study aimed at evaluating the impact of cerebrovascular risk factors on the clinical expression of idiopathic adult onset dystonia (IAOD), with reference to dystonia localization and dystonia-associated features. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 11, 2023 Category: Neurology Authors: Marcello Mario Mascia, Daniele Belvisi, Marcello Esposito, Roberta Pellicciari, Assunta Trinchillo, Carmen Terranova, Salvatore Bertino, Laura Avanzino, Francesca Di Biasio, Francesco Bono, Vincenzo Laterza, Christian Lettieri, Roberto Eleopra, Giovanni F Source Type: research

Essential and dystonic head tremor: More similarities than differences
Head tremor is a common symptom of essential tremor (ET) and cervical dystonia (CD). In clinical practice, it is often difficult to distinguish between these two conditions, especially in cases where head tremor predominates. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 8, 2023 Category: Neurology Authors: Petr Holl ý, Tereza Duspivová, David Kemlink, Olga Ulmanová, Jan Rusz, Radim Krupička, Robert Jech, Evžen Růžička Source Type: research

Augmented reality cueing for freezing of gait: Reviewing an emerging therapy
Freezing of gait (FoG) is a common symptom of Parkinson's Disease (PD) that can decrease quality of life and cause devastating falls [1]. FoG is a sensation of being stuck in place or incapable of stepping despite the desire to do so [2]. It is commonly triggered by walking through doorways, turning, or beginning movement from a stopped state but can happen in open spaces without obstacles. The neural pathophysiology of FoG is poorly understood and it can present differently between individuals [1 –4]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 7, 2023 Category: Neurology Authors: Brendan Baugher, Nathaniel Szewczyk, James Liao Tags: Review article Source Type: research

Atypical brain FDG-PET patterns increase the risk of long-term cognitive and motor progression in Parkinson's disease
Brain hypometabolism patterns have been previously associated with cognitive decline in Parkinson's disease (PD). Our aim is to evaluate the impact of single-subject fluorodeoxyglucose (FDG)-PET brain hypometabolism on long-term cognitive and motor outcomes in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 6, 2023 Category: Neurology Authors: Alberto Imarisio, Andrea Pilotto, Enrico Premi, Silvia Paola Caminiti, Luca Presotto, Arianna Sala, Cinzia Zatti, Alessandro Lupini, Rosanna Turrone, Barbara Paghera, Barbara Borroni, Daniela Perani, Alessandro Padovani Source Type: research

A new genetic variant, presenting as young onset rapidly progressive dementia and parkinsonism
There are various neurodegenerative or hereditary causes of Parkinsonism. Therefore, clinicians should consider an increasing range of differential diagnoses when facing a patient with Parkinsonism, especially when associated with additional clinical features. Young-onset Parkinsonism, especially when accompanied by features uncommon in idiopathic Parkinson's disease raises the possibility of genetic etiology.Herein, we present a case of a 40-year-old man with genetic Parkinson's disease, presenting with rapidly progressive dementia. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 6, 2023 Category: Neurology Authors: Negin Eissazadeh, Afagh Alavi, Anthony E. Lang, Mohammad Rohani, Maziar Emamikhah, Tara Khoeini Source Type: research

Heterozygous YY1 mutation – A mimicker of SGCE-myoclonus-dystonia
Gabriele De Vries syndrome (GDVS) is a condition that has only recently been identified. It is characterized by intellectual disability (ID), dysmorphic features, intrauterine growth retardation (IUGR), congenital anomalies and feeding problems. Seven of 28 currently identified cases had movement disorder. Our patient primarily had abnormal movements without intellectual disability, which is the core feature of this disease. Hence this case highlights the evolving phenotype of this relatively new disorder. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 5, 2023 Category: Neurology Authors: Tanushree Chawla, Natasha K. Kumar, Vinay Goyal Source Type: research

Educational level and its association with dopamine transporter loss in patients with Parkinson's disease
According to the cognitive-reserve concept, higher educated dementia patients tolerate more brain pathology than lower educated patients with similar impairment. Here, we examined whether higher education is associated with more severe dopamine terminal loss at the diagnosis of Parkinson's disease (PD). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 4, 2023 Category: Neurology Authors: Merle C. Hoenig, Verena Dzialas, Magdalena Banwinkler, Adrian Asendorf, Alexander Drzezga, Thilo van Eimeren Tags: Short communication Source Type: research

Staying hidden: The burden of stigma in PD
Despite the myriad motor and non-motor challenges associated with Parkinson's disease (PD) diagnosis, the hidden issue of stigma may be among the most influential factors negatively affecting quality of life. A number of qualitative studies have been published assessing various aspects of stigma in PD, and quantitative studies assert that most people with PD experience stigma during the course of their disease. Stigma is associated with poorer mental and physical health, poorer quality of life, decreased levels of hope, self-esteem and self-efficacy. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 3, 2023 Category: Neurology Authors: Bradley McDaniels, Gregory M. Pontone, Soania Mathur, Indu Subramanian Tags: Review article Source Type: research

Comparative safety of antimuscarinics versus mirabegron for overactive bladder in Parkinson disease
Overactive bladder (OAB) is a common nonmotor symptom of Parkinson disease (PD), often treated with antimuscarinics or beta-3 agonists. There is lack of evidence to guide OAB management in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 2, 2023 Category: Neurology Authors: Danielle S. Abraham, Thanh Phuong Pham Nguyen, Craig W. Newcomb, Shelly L. Gray, Sean Hennessy, Charles E. Leonard, Qing Liu, Daniel Weintraub, Allison W. Willis Source Type: research

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(Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 1, 2023 Category: Neurology Source Type: research