Fine-Tuning the Brain: The Role of Local Field Potentials in DBS Programming
Since its introduction in 1987, Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus (GPi) has become an established surgical treatment for patients with Parkinson ’s disease (PD) who suffer from medically refractory tremor or motor fluctuations. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 4, 2024 Category: Neurology Authors: Mustafa S. Siddiqui, Zoltan Mari Source Type: research
The prevalence of non-troublesome dyskinesia in Parkinson's disease
This study investigated prevalence and severity of dyskinesia, particularly non-troublesome dyskinesia, to provide insights into its significance for long-term PD management. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 3, 2024 Category: Neurology Authors: Hee Jin Chang, Mihee Jang, Kyung Ah Woo, Jung Hwan Shin, Han-Joon Kim, Beomseok Jeon Tags: Short communication Source Type: research
Early-onset levodopa responsive parkinsonism in PPP2R5D mutation
The gene PPP2R5D encodes the regulatory subunit B56 of PP2A, a serine-threonine phosphatase that plays an important regulatory role in cellular processes, including proliferation, apoptosis, and signal transduction, and is primarily expressed in the brain. The de novo missense variants in the gene PPP2R5D are reported to be associated with neurodevelopmental delay, intellectual disability, macrocephaly, motor and coordination deficits, epilepsy, visual impairment, and autism spectrum disorders [1]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 3, 2024 Category: Neurology Authors: Rohan Mahale, Gautham Arunachal, Deepak Chadha, Hansashree Padmanabha, Pooja M, Mathuranath Pavagada Tags: Correspondence Source Type: research
CSF N-acylethanolamine acid amidase level and Parkinson's disease risk: A mendelian randomization study
This study aimed to explore the causal effect of CSF NAAA levels on PD risk through Mendelian randomization (MR) analysis. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 1, 2024 Category: Neurology Authors: Youjie Zeng, Ren Guo, Si Cao, Chunxia Liu, Heng Yang Source Type: research
Editorial Board
(Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 1, 2024 Category: Neurology Source Type: research
The utility of the irritability scale in Huntington's disease patients with evidence of irritability or aggression
Irritability, a common neuropsychiatric symptom in Huntington's disease (HD), lacks a standardized measurement. The Irritability Scale (IS), tailored for HD, has patient and informant versions, but variable interrater agreement has been reported frequently in previous studies. To enhance the clinical utility of the IS, this study aimed to identify the most reliable components estimating the underlying construct and develop a shortened version for time-limited contexts. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 29, 2024 Category: Neurology Authors: Joyce En-Hua Wang, Neal G. Simon, Michael Brownstein, Hilda T. Maibach, Jacob Maibach, Karen Elta Anderson Source Type: research
Predicting slight freezing of gait in Parkinson's disease with anticipatory postural adjustments and limits of stability
We examined the effects of automatic movements (anticipatory postural adjustments [APAs]) and voluntary movements (limits of stability [LOS]) on the first step (first-step duration and first-step range of motion), along with their early recognition and prediction of slight FOG. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 29, 2024 Category: Neurology Authors: Weijia Hou, Fan Wu, Yue Wang, Weihua Li, Yuanyuan Cheng, Zhizhong Zhu, Siquan Liang, Peipei Liu, Yang Yu, Jialing Wu Tags: Short communication Source Type: research
Impaired glymphatic clearance in multiple system atrophy: A diffusion spectrum imaging study
Impaired α-synuclein clearance is pivotal in the pathogenesis of neurodegenerative diseases. We evaluated glymphatic clearance in multiple system atrophy (MSA) patients using advanced imaging. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 29, 2024 Category: Neurology Authors: Chuanying Shi, Guifang Guo, Weifei Wang, Haiyan Yu, Hua Fan, Peng Wu, Peiji Song, Dianrong Gong Tags: Short communication Source Type: research
Association of intestinal inflammation and permeability markers with clinical manifestations of Parkinson's disease
Intestinal inflammation and gut microbiota dysbiosis can stimulate degeneration of dopaminergic neurons and development of Parkinson's disease (PD) via the gut-brain axis in certain patients. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 26, 2024 Category: Neurology Authors: Ines Rajkovaca Latic, Zvonimir Popovic, Katica Mijatovic, Ines Sahinovic, Vlasta Pekic, Domagoj Vucic, Vesna Cosic, Blazenka Miskic, Svetlana Tomic Source Type: research
Progressive QTc prolongation and reduced heart rate variability in dementia with Lewy bodies compared to Alzheimer's disease
Autonomic dysfunction (AuD) is a significant clinical challenge in patients with Dementia with Lewy Bodies (DLB). Manifestations of AuD such as orthostatic hypotension (OH) is associated with falls and decreased quality of life. Cardiac autonomic denervation is an early phenomenon in DLB and a potential contributor to OH. This retrospective study was undertaken to explore whether routine ECG tracings could be used to identify signs of autonomic dysfunction in DLB. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 25, 2024 Category: Neurology Authors: Mattias Haglund, Isak Heyman, Keivan Javanshiri Tags: Short communication Source Type: research
Clinical, neuroimaging and genetic findings in Brazilian patients with neurodegeneration with brain iron accumulation
Neurodegeneration with brain iron accumulation (NBIA) encompasses a clinically and genetically heterogeneous group of rare disorders. Here, we report clinical, neuroimaging and genetic studies in twenty three Brazilian NBIA patients. In thirteen subjects, deleterious variants were detected in known NBIA-causing genes (PANK2, PLA2G6, C9ORF12, WDR45 and FA2H), including previously unreported variants in PANK2 and PLA2G6. Two patients carried rare, likely pathogenic variants in genes not previously associated with NBIA: KMT2A c.11785A > C (p.Ile3929Leu), and TIMM8A c.127T > C (p.Cys43Arg), suggesting an expansion of ...
Source: Parkinsonism and Related Disorders - March 22, 2024 Category: Neurology Authors: Rubens Paulo Ara újo Salomão, Flávio Moura de Rezende Filho, Vanderci Borges, Manju A. Kurian, Henrique Balallai Ferraz, Guido J. Breedveld, Vincenzo Bonifati, Orlando G. Barsottini, José Luiz Pedroso Source Type: research
Voice self-assessment in individuals with Parkinson's Disease as compared to general voice disorders
This study aimed to compare self-reported vocal symptoms and voice loudness between IwPD and GVD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 22, 2024 Category: Neurology Authors: Francisco Contreras-Ruston, Adri án Castillo-Allendes, Jorge Saavedra-Garrido, Andrés Felipe Ochoa-Muñoz, Eric J. Hunter, Sonja A. Kotz, Jordi Navarra Source Type: research
Interdisciplinary insights into tremor in dystonia: Navigating clinical controversies, definitional challenges, and pathophysiological complexities
This review delves into the historical evolution and ongoing controversy surrounding the relationship between tremor and dystonia. The Dystonia Consensus Panel and the International Parkinson's and Movement Disorders Society's Tremor Taskforce have attempted to define these entities, but the complexity arises when patients have a combination of both dystonia and tremor. The term "dystonic tremor" has sparked diverse interpretations, with debates over its clinical features and the need for more objectively defined characteristics. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 21, 2024 Category: Neurology Authors: Aasef G. Shaikh, H.A. Jinnah Tags: Review article Source Type: research
Elderly-onset severe parkinsonism in Wilson Disease: Expert Commentary
There are no conflicts of interest and all the authors listed have approved the manuscript that is enclosed. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 21, 2024 Category: Neurology Authors: Laxmi Patil, Gaurav Mehta, Annu Aggarwal Source Type: research
Commentary on: A new genetic variant, presenting as young onset rapidly progressive dementia and parkinsonism
In September edition of Movement Disorders Rounds, Dr. Negin Eissazade et al. describe an interesting young patient who developed a rapidly progressive parkinsonism and dementia syndrome secondary to a novel homozygous missense mutation in the alpha-synuclein (SNCA) gene [1]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 21, 2024 Category: Neurology Authors: M. Claudia Uribe Roca Source Type: research
