‘Comb sign' in mitochondrial membrane protein associated neurodegeneration: Revelation from 5 cases
Background: Mitochondrial membrane protein associated neurodegeneration (MPAN) is a subtype of neurodegeneration with brain iron accumulation (NBIA) caused by homozygous pathogenic mutations in the C19orf12 gene. It is characterised by progressively increasing spasticity, neuropsychiatric issues and dystonia, in varying combinations. Other less common manifestations include optic atrophy, neuropathy and parkinsonism. MRI brain typically reveals iron accumulation in the globus pallidi (GP) and substantia nigra (SN), but sparing the medial medullary lamina (isointense streaking) separating the hypointense GP externa and inte...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Agarwal, D. Garg, A. Garg, R. Rajan, A.K. Srivastava Source Type: research
Speech Biomarkers for Dysarthria in Parkinson's Disease — Clinical Validation Across Spanish and Czech Languages
This study investigates reliable speech biomarkers for Parkinson's disease-related dysarthria, ensuring cross-language clinical validity. It assesses performance on sustained phonation (SPA) and rapid syllable repetition (DDK), chosen for practicality and reduced patient-burden. ki:elements SIGMA pipeline extracts clinically relevant speech features, controlling for age and gender influences. Composite scores are evaluated for clinical validity using UPDRS-III, UPDRS-Speech, H&Y scales, and assessed across both languages. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E. Baykara, F. D örr, J. Rusz, J.R. Orozco-Arroyave, J. Tröger Source Type: research
Risk factors for Parkinson's disease and Parkinson's disease with cognitive impairment in high altitude: A case-control study
Background: To explore the risk factors associated with Parkinson ’s disease (PD) and PD with cognitive impairment (PD-CI) in a high altitude area. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Zhu, Y. Liang Source Type: research
User-Centric Design of a Biochemical Sensor for Parkinson's Disease: A Survey-Based Approach to Understand Community Expectations and Values
The objective is to align the device with scientific and technological standards while prioritizing the practical expectations and values of the end-users. This approach aims to seamlessly integrate advanced technologies into the daily lives of individuals with Parkinson's disease, ultimately improving overall well-being and treatment experience. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: B. Dupre, K. Stromodst, K. House, J. Shupe Source Type: research
First-year Treatment Intensity and Prognosis in Early Parkinson ’s Disease: A Retrospective, Longitudinal Study in Israel
Background: Given Parkinso ńs disease (PD) heterogeneity, it is challenging to find associations between patients’ characteristics and prognosis. We compared long term disease prognosis among people with Parkinson's Disease (PwPD) by treatment intensity in the first year after PD diagnosis. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y. Barer, O. S ánchez-Soliño, D. Arkadir, M. Grabarnik-John, G. Chodick, L. Bergmann, C.H. Yan Source Type: research
Association of small right vagus nerve cross-sectional area with abnormal heart rate variability
Background: In Parkinson's disease (PD), autonomic dysfunction occurs throughout the disease course. The vagus nerve is a crucial component of the autonomic nervous system. Cardiac autonomic dysfunction is present in the early stage of PD. The cross-sectional area (CSA) of the vagus nerve, measured by ultrasound, is significantly reduced in PD patients. We aimed to investigate the association between vagus nerve CSA measured by ultrasound and autonomic function in patients with early PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Lee, H.L. Lee, J.-W. Park, S.-B. Koh Source Type: research
The role of neurotrophic factors in development Parkinson's disease dementia
Background: The purpose of our study is to evaluate NGF in the development of cognitive impairment and dementia in patients with PDD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Okhunova, G. Rakhimbaeva Source Type: research
The potential use of plasma GFAP as a diagnostic and prognostic biomarker of motor subtype in early Parkinson ’s disease
Background: Parkinson ’s disease (PD) is a heterogeneous movement disorder with different motor subtypes including tremor dominant (TD), indeterminate and postural instability, and gait disturbance (PIGD) motor subtypes. Plasma glial fibrillary acidic protein (GFAP) was elevated in PD patients and may be regarded as a biomarker for motor and cognitive progression. Here we explore if there was an association between plasma GFAP and different motor subtypes and whether baseline plasma GFAP level can predict motor subtype conversion. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: N. Che, R. Ou, C. Li, L. Zhang, Q. Wei, S. Wang, Q. Jiang, T. Yang, Y. Xiao, J. Lin, B. Zhao, X. Chen, H. Shang Source Type: research
“Pop-up” studies: Observational studies in Huntington disease conducted at annual family convention
Background: Huntington ’s disease (HD) is a rare trinucleotide repeat disorder caused by mutation in Huntingtin gene. Availability of biomarkers that track disease progression is of crucial value. Rare disease patient advocacy organizations host annual conventions attended by large number of motivated and engaged famili es creating research opportunities. CHDI, a nonprofit organization dedicated to HD research, conducted “pop-up” observational studies, akin to pop-up stores that open suddenly and exist for short duration, at an annual lay organization convention in 2022 and 2023. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Sathe, K. Johnson, C. Sampaio, Pop-up Study Team Source Type: research
Nebulized Administration of Roasted Mucuna Powder Using a Hydrogen Water Superheated System in Parkinson's Disease
In this study, we present a new administration method for Mucuna powder and discuss an innovative ideal administration approach. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R. Neshige Source Type: research
The brain fMRI study of patients with Parkinson's disease and pain induced by contact heat stimulations
Background: To observe the features of functional magnetic resonance imaging (fMRI) of Parkinson's disease with pain( PDP) and Parkinson's disease without pain (nPDP) under contact hot pain stimulation (CHS), and explore the brain network related to pain in PDP. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: P. Qiao-Jun, W. Xiao-Ming Source Type: research
Delphi Analysis: Anatomy and Botulinum Neurotoxin Type-A (BoNT-A) Injection Training for Spasticity and Dystonia
Background: Effective treatment with botulinum neurotoxin type-A (BoNT-A) injection in spasticity and dystonia requires in-depth knowledge of muscle anatomy and injection-guidance methods, such as ultrasound (US). As there are no global, standardised best practices in these areas, this research provides expert consensus on best practices for anatomy teaching and training on US-guided BoNT-A injection for specialists who treat patients with spasticity and dystonia. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: K. Heckert, B. Biering-S ørensen, T. Bäumer, O.D. Khan, F. Pagan, M. Paulin, T. Stitik, M. Verduzco-Gutierrez, R. Reebye Source Type: research
Application of motor rehabilitation programs in the normalization of the psycho-emotional sphere of patients with Parkinson`s disease
Background: To study the effectiveness of the motor rehabilitation programme rehabilitation programme for patients with Parkinson's disease (PD), 48 patients were clinically examined who had undergone a course of motor rehabilitation using the phenomenon of paradoxical kinesia phenomenon and subsequently followed the recommendations in different ways. rehabilitation recommendations. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: I. Voloshyn-Haponov, N. Voloshyna, I. Bogdanova Source Type: research
Characterization of the pattern of daily motor fluctuations in Parkinson ’s disease patients based on home diaries
Background: Parkinson ’s disease (PD) patients are often in their best clinical state when attending medical appointments. It is therefore important for clinicians to be familiar with the typical pattern of motor fluctuations that patients experience and to obtain a good history regarding potential fluctuations even wh en patients are doing well at the time of the evaluation. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R.A. Hauser, W. Poewe, J.J. Ferreira, A. Lees, G.S. Liang, M. Fonseca, D. Magalh ães, J. Rocha, P. Soares-da-Silva Source Type: research
Absence of causal relationship between Parkinson ’s disease and subsequent prostate cancer: Evidence from meta-analysis and Mendelian randomization studies
Background: Numerous observational studies have investigated the risk of prostate cancer (PCa) in patients diagnosed with Parkinson ’s Disease (PD). However, the existence of a definitive association remains uncertain. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J.-Y. Deng, X.-M. Wang Source Type: research
