Corneal confocal microscopy demonstrates varying degrees of neurodegeneration in atypical parkinsonian disorders
We have used corneal confocal microscopy (CCM) to identify corneal nerve loss as a potential marker of neurodegeneration in participants with Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - November 4, 2023 Category: Neurology Authors: Sze Hway Lim, Maryam Ferdousi, Shakya Bhattacharjee, Alise Kalteniece, Ziyad R. Mahfoud, Ioannis N. Petropoulos, Rayaz A. Malik, Christopher Kobylecki, Monty Silverdale Tags: Short communication Source Type: research
Association between lipid levels and the risk of Parkinson's disease in individuals with diabetes mellitus: A nationwide population-based cohort study
This study aimed to examine the association between lipid levels and the risk of PD in individuals with DM and evaluate whether the association changes with the use of statins. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - November 3, 2023 Category: Neurology Authors: Hyo Jeong Lee, Kyungdo Han, Yong Wook Kim, Seung Nam Yang, Seo Yeon Yoon Source Type: research
Estimating the prevalence and incidence of multiple system atrophy in the USA: Insights from a national claims database
The objective of this study was to estimate the prevalence and cumulative incidence of MSA in the US. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - November 3, 2023 Category: Neurology Authors: Sigal Kaplan, Handing Xie, Jing Wang Tags: Short communication Source Type: research
Childhood onset myoclonus-dystonia associated with a novel KCTD17 variant in an Indian patient
Myoclonus-dystonia (MD)is a rare condition defined mainly by upper body prominent myoclonus which dominates over dystonia, absence of truncal dystonia, associated psychiatric comorbidities, onset below 18 years of age and a positive family history [1]. Around 20 –50 % have pathogenic variants in epsilon-sarcoglycan (SGCE) gene on chromosome 7q21. Pathogenic variants in potassium channel tetramerization domain-containing protein 17 (KCTD17) (OMIM 616386) were initially reported in 2015 as a rarer cause of MD [2]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - November 2, 2023 Category: Neurology Authors: Divyani Garg, Himanshi Kapoor, Istaq Ahmad, Mir Aroosa, Ayush Agarwal, Achal Kumar Srivastava, Mohammed Faruq Tags: Correspondence Source Type: research
Editorial Board
(Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - November 1, 2023 Category: Neurology Source Type: research
Autonomic dysregulation during sleep in Parkinsonian spectrum disorders - A proof of concept
Autonomic dysfunction is common in α-synucleinopathies such as Lewy Body dementias (LBD), Parkinson's disease (PD), and isolated REM Sleep Behavior Disorder (iRBD). We analyzed pulse-rate changes during sleep to index autonomic nervous system (ANS) dysfunction in patients with α-synucleinopathies vs. non-synucleinopathy groups expe cted to have normal ANS function. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - November 1, 2023 Category: Neurology Authors: Yeilim Cho, Daniel J. Levendowski, Christine M. Walsh, Debby Tsuang, Joyce K. Lee-Iannotti, Chris Berka, Gandis Mazeika, David Salat, Joanne M. Hamilton, Bradley F. Boeve, Thomas C. Neylan, Erik K. St Louis Tags: Short communication Source Type: research
Sex distribution and classification of GBA1 variants in an Italian cohort of Parkinson's disease patients analyzed over the last seventeen years
Heterozygous GBA1 variants are among the most frequent genetic risk factors for Parkinson's disease (PD). Male sex is a risk factor in the development of PD but the sex prevalence of GBA1 carriers in PD patients remains debatable. Molecular analysis of the GBA1 gene is complicated by the presence of a highly homologous pseudogene GBAP1. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - October 31, 2023 Category: Neurology Authors: Celeste Panteghini, Chiara Reale, Isabel Colangelo, Marta Suerz, Alessia Catania, Barbara Garavaglia, Federica Invernizzi Source Type: research
Increased brain cholinergic innervation in isolated REM sleep behaviour disorder from prodromal multiple system atrophy
Multiple system atrophy (MSA) is a synucleinopathy marked by glial cytoplasmic inclusions and presents either with cerebellar ataxia (MSA-C type) or, more frequently, with parkinsonism (MSA-P type). Although degeneration of the nigrostriatal dopaminergic system is common in MSA, post-mortem and brain imaging studies have also consistently found cholinergic lesions. In vivo cholinergic denervation has been shown to occur in the brainstem, thalamus, and cortex in individuals diagnosed with probable MSA [1], and cell loss has been discovered in the cholinergic brainstem nuclei upon autopsy [2]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - October 31, 2023 Category: Neurology Authors: Rebekah H. Wickens, Ronald B. Postuma, Étienne de Villers-Sidani, Amélie Pelletier, Stephan Blinder, Jean-François Gagnon, Jean-Paul Soucy, Jacques Montplaisir, Marc-André Bedard Tags: Correspondence Source Type: research
Functional neurological disorders and Parkinson's disease – A new research agenda?
We read with interest the article by Delgado and colleagues that delved into the intricate relationship between FND and PD [1]. The study investigated the presence of functional motor disorders (FMDs), a subtype of functional neurological disorder (FND), in a cohort of 56 Parkinson's disease (PD) patients from five Movement Disorders Units in Spain. The study identified 28 patients who shared both FMD and PD (FMD-PD patients) and confirmed the findings of a few prior studies indicating the predominance of women in the condition, the more frequent occurrence of functional symptoms on the body side most affected by PD, and t...
Source: Parkinsonism and Related Disorders - October 30, 2023 Category: Neurology Authors: Tommaso Ercoli, Paolo Solla, Jon Stone, Giovanni Defazio Tags: Correspondence Source Type: research
Current genetic data on depression and anxiety in Parkinson's disease patients
Parkinson's disease (PD) is a common neurodegenerative disorder affecting about 1 % of the population over the age of 60 years. PD is characterized by a wide spectrum of symptomatology including not only motor symptoms but non-motor symptoms, as well. Depression is one of the most common non-motor manifestations, and the most frequent neuropsychiatric comorbidity in PD. Neurop sychiatric symptoms like depression and anxiety may precede the appearance of motor features, highlighting their importance in the early detection of the disease and its strategic management. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - October 30, 2023 Category: Neurology Authors: Kallirhoe Kalinderi, Vasileios Papaliagkas, Liana Fidani Tags: Review article Source Type: research
Randomized controlled trial of KW-6356 monotherapy in patients with early untreated Parkinson's disease
KW-6356 is a novel selective adenosine A2A receptor antagonist/inverse agonist. We evaluated the efficacy and safety of KW-6356 as monotherapy in patients with early, untreated Parkinson's disease (PD). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - October 30, 2023 Category: Neurology Authors: Maeda Tetsuya, Takashi Kimura, Kenichiro Sugiyama, Kana Yamada, Ren Hiraiwa, Masato Nishi, Nobutaka Hattori, 6356-002 study group Source Type: research
Looking beyond the brain: Insights into vascular parkinsonism with optical coherence tomography
In this study, we report the pattern of changes in the retinal and choroidal layers in patients with VP with the help of spectral domain OCT (SD-OCT). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - October 28, 2023 Category: Neurology Authors: Aakash Agrawa, Pooja Mailankody, Rajani Battu, Amitabh Bhattacharya, Mohammed Shereef Pm, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal Tags: Short communication Source Type: research
Examining the link between impulse control disorder and antidepressant use in Parkinson's disease
Impulse control disorders (ICD) in Parkinson's disease (PD) and hypomanic episodes of bipolar disorder show overlapping symptoms, suggesting a shared neurobiology. To explore this, the following hypotheses are tested: (1) larger changes in affective symptoms from OFF to ON medication states will be associated with ICD, (2) antidepressant exposure will be associated with larger OFF to ON affective symptom changes, and (3) antidepressant exposure will be associated with ICD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - October 28, 2023 Category: Neurology Authors: Christopher B. Morrow, Jared T. Hinkle, Joseph Seemiller, Kelly A. Mills, Gregory M. Pontone Source Type: research
β-Caryophyllene decreases neuroinflammation and exerts neuroprotection of dopaminergic neurons in a model of hemiparkinsonism through inhibition of the NLRP3 inflammasome
Parkinson's disease represents a neurodegenerative condition characterized by the progressive loss of dopaminergic neurons within the Substantia Nigra pars compacta (SNpc), resulting in diminished dopamine levels in the striatum (STR) and chronic neuroinflammation. Recent investigations have proposed the neuroprotective potential of the endocannabinoid system in neurodegenerative disorders. β-caryophyllene (BCP) is recognized for its antioxidant and anti-inflammatory properties, attributed to its activation of the type 2 cannabinoid receptor. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - October 27, 2023 Category: Neurology Authors: Patricia Alejandra Brand-Rubalcava, Aldo Rafael Tejeda-Mart ínez, Orfil González-Reynoso, Angelica Yanet Nápoles-Medina, Verónica Chaparro-Huerta, Mario Eduardo Flores-Soto Source Type: research
Late-onset parkinsonism in a patient with a novel frameshift THAP1 variant
DYT-THAP1 dystonia (formerly referred as “DYT6”) is an isolated dystonia, typically presenting as an early onset generalized or segmental phenotype [1]. DYT-THAP1 is inherited in an autosomal dominant manner, with reduced penetrance, and caused by pathogenic variants in the THAP1 gene [2]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - October 25, 2023 Category: Neurology Authors: Edouard Courtin, Natalia Hernandez Poblete, Fabienne Clot, Dominique Guehl, Pierre Burbaud Source Type: research
