Exploring the connection between Parkinson's disease and Sj ögren's syndrome: The aquaporin link
Parkinson's disease (PD) is a prevalent and progressive neurodegenerative condition affecting more than 1% of the population over the age of 60 years. The disease is characterized by the presence of α-synuclein aggregates and loss of dopaminergic neurons in the substantia nigra. Recent large-scale genomic studies and advances in mechanistic understanding have shed light on the significance of misfolded synuclein aggregates, as well as abnormalities in crucial pathways related to protein cleara nce through the lysosomal-autophagy system, immune responses, and mitochondrial function. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 22, 2023 Category: Neurology Authors: Pulukool Sandhya, Debasish Danda Source Type: research
Action observation and motor imagery improve motor imagery abilities in patients with Parkinson ’s disease – A functional MRI study
Motor imagery (MI) skills can be affected in Parkinson's disease (PD). We aim at assessing MI and brain functional changes after action observation and MI training (AOT-MI) associated with gait/balance exercises in PD patients with postural instability and gait disorders (PD-PIGD). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 21, 2023 Category: Neurology Authors: Elisabetta Sarasso, Andrea Gardoni, Lucia Zenere, Elisa Canu, Silvia Basaia, Elisa Pelosin, Maria Antonietta Volont è, Massimo Filippi, Federica Agosta Source Type: research
Healthy diet versus added sugars and unsaturated fatty acids in Parkinson's disease: Food for thought
The environment versus gene dichotomy in Parkinson's disease (PD) is, as in many other human chronic conditions, a longstanding controversy nowadays viewed as a matter of convergence rather than divergence. One of many environmental factors that can impact on molecular pathways leading to PD, including gene expression, is diet. Hence, dietary habits can modify, through a variety of candidate mechanisms different aspects of neurodegeneration, such as oxidative stress, inflammation or even protein aggregation (see further on). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 20, 2023 Category: Neurology Authors: Marcos Carrasco, Ana Camara, Yaroslau Compta Source Type: research
Immune-mediated ataxias: Guide to clinicians
Immune-mediated cerebellar ataxias were initially described as a clinical entity in the 1980s, and since then, an expanding body of evidence has contributed to our understanding of this topic. These ataxias encompass various etiologies, including postinfectious cerebellar ataxia, gluten ataxia, paraneoplastic cerebellar degeneration, opsoclonus-myoclonus-ataxia syndrome and primary autoimmune cerebellar ataxia. The increased permeability of the brain-blood barrier could potentially explain the vulnerability of the cerebellum to autoimmune processes. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 20, 2023 Category: Neurology Authors: Alex T. Meira, Marianna P.M. de Moraes, Matheus Gomes Ferreira, Gustavo L. Franklin, Fl ávio Moura Rezende Filho, Hélio A.G. Teive, Orlando G.P. Barsottini, José Luiz Pedroso Tags: Review article Source Type: research
Healthy diet versus added sugars and unsaturated fatty acids in Parkinson ’s disease: Food for THOUGHT
The environment versus gene dichotomy in Parkinson ’s disease (PD) is, as in many other human chronic conditions, a longstanding controversy nowadays viewed as a matter of convergence rather than divergence. One of many environmental factors that can impact on molecular pathways leading to PD, including gene expression, is diet. Hence, dietary hab its can modify, through a variety of candidate mechanisms different aspects of neurodegeneration, such as oxidative stress, inflammation or even protein aggregation (see further on). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 20, 2023 Category: Neurology Authors: Marcos Carrasco, Ana Camara, Yaroslau Compta Source Type: research
Acute effect of levodopa on orthostatic hypotension and its association with motor responsiveness in Parkinson's disease: Results of acute levodopa challenge test
Levodopa administration can induce or worsen orthostatic hypotension (OH) in patients with Parkinson's disease (PD). Understanding of acute OH post levodopa (AOHPL) is important for rational drug use in PD patients. Primary objective of this study was to investigate the incidence of AOHPL in PD patients. The secondary objectives were a) hemodynamic character of AOHPL; b) risk factors of AOHPL; c) relationship between motor responsiveness and blood pressure (BP) change. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 19, 2023 Category: Neurology Authors: Zhu Liu, Dongning Su, Junhong Zhou, Xuemei Wang, Zhan Wang, Yaqin Yang, Huizi Ma, Tao Feng Source Type: research
Device-aided therapies for Parkinson's disease: "All for one, one for all, that is our device"
In this issue of Parkinsonism and Related Disorders, Fernandez and colleagues have conducted a study that used a validated tool to classify PD patients to determine who may benefit from device-aided therapies. The tool, called ‘MANAGE-PD’ used data collected from 563 neurologists on 2709 PD patients already receiving oral therapy and were naïve to device-aided therapies, such as levodopa/carbidopa intestinal gel (LCIG), continuous subcutaneous apomorphine infusion (CSAI), or deep brain stimulation (DBS). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 18, 2023 Category: Neurology Authors: Deborah Hall Source Type: research
Device-Aided Therapies for Parkinson ’s Disease: All for One, One for All, That is our Device (Alexandre Dumas)
In this issue of Parkinsonism and Related Disorders, Fernandez and colleagues have conducted a study that used a validated tool to classify PD patients to determine who may benefit from device-aided therapies. The tool, called ‘MANAGE-PD’ used data collected from 563 neurologists on 2709 PD patients already receiving oral therapy and were naïve to device-aided therapies, such as levodopa/carbidopa intestinal gel (LCIG), continuous subcutaneous apomorphine infusion (CSAI), or deep brain stimulation (DBS). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 18, 2023 Category: Neurology Authors: Deborah Hall Source Type: research
Omics profile of iPSC-derived astrocytes from Progressive Supranuclear Palsy (PSP) patients
Progressive Supranuclear Palsy (PSP) is a neurodegenerative tauopathy and, to date, the pathophysiological mechanisms in PSP that lead to Tau hyperphosphorylation and neurodegeneration are not clear. In some brain areas, Tau pathology in glial cells appears to precede Tau aggregation in neurons. The development of a model using astrocyte cell lines derived from patients has the potential to identify molecules and pathways that contribute to early events of neurodegeneration. We developed a model of induced pluripotent stem cells (iPSC)-derived astrocytes to investigate the pathophysiology of PSP, particularly early events ...
Source: Parkinsonism and Related Disorders - September 16, 2023 Category: Neurology Authors: Felipe G. Ravagnani, Hellen P. Valerio, Jersey H.S. Mau és, Arthur N. de Oliveira, Renato D. Puga, Karina Griesi-Oliveira, Fabíola R. Picosse, Henrique B. Ferraz, Rodrigo R. Catharino, Graziella E. Ronsein, Patrícia de Carvalho Aguiar Source Type: research
Beneficial effects of activity level on striatal binding: careful replication is required
The spotlight article by Jin et al. [1] supports a previous publication analyzing the PPMI database showing that physical activity may modify disease progression for people with Parkinson ’s disease [2]. The finding is also quite consistent with three studies that have all suggested that six months of high intensity endurance exercise shows a reduced rate of decline in the MDS-UPDRS part III in comparison to moderate intensity exercise [3-5]. The present study adds to these finding s by showing a reduced decline in dopamine uptake over time in people with Parkinson’s disease that is related to physical activity. (Sourc...
Source: Parkinsonism and Related Disorders - September 15, 2023 Category: Neurology Authors: Daniel M. Corcos Source Type: research
Understanding cognitive changes in patients with Parkinson's disease using novel fiber quantification techniques
Beyond the cardinal motor symptoms, cognitive impairment emerges as a significant non-motor symptom, affecting approximately 30 –40% of individuals with Parkinson's disease (PD) during its initial stages. As the disease advances, the majority—up to 80%—will develop cognitive impairment, potentially leading to dementia [1,2]. Research findings suggest that the changes in white matter (WM) structure could serve as a valu able biomarker in the early stages of PD [3]. This potential is underscored by the ability of diffusion tensor imaging (DTI) to identify degenerations within WM that are correlated with cognitive impai...
Source: Parkinsonism and Related Disorders - September 13, 2023 Category: Neurology Authors: Anupa A. Vijayakumari, Virendra R. Mishra Source Type: research
Understanding Cognitive Changes in Patients with Parkinson ’s Disease Using Novel Fiber Quantification Techniques
Beyond the cardinal motor symptoms, cognitive impairment emerges as a significant non-motor symptom, affecting approximately 30-40% of individuals with Parkinson's disease (PD) during its initial stages. As the disease advances, the majority —up to 80%—will develop cognitive impairment, potentially leading to dementia [1, 2]. Research findings suggest that the changes in white matter (WM) structure could serve as a valuable biomarker in the early stages of PD [3]. This potential is underscored by the ability of diffusion tensor imag ing (DTI) to identify degenerations within WM that are correlated with cognitive impair...
Source: Parkinsonism and Related Disorders - September 13, 2023 Category: Neurology Authors: Anupa A. Vijayakumari, Virendra R. Mishra Source Type: research
Genetic literacy and attitude towards genetic testing in patients with Parkinson's disease and their caregivers: A review of literature
Genetic literacy refers to an individual's ability to understand the basics of genetic concepts and apply them to health-related decisions. The level of genetic literacy influences attitude towards genetic testing and is, in turn, influenced by several other factors. Clinicians must be aware of the genetic literacy of their patients and their caregivers before advising genetic testing and/or undertaking pre and post-test counseling. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 12, 2023 Category: Neurology Authors: Sneha D. Kamath, Vikram V. Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal Tags: Review article Source Type: research
Nigrostriatal dysfunction in RFC1-related disorder/CANVAS
Parkinsonism is now recognized as an additional feature in RFC1/CANVAS syndrome; however, no systematic evaluation of nigrostriatal dopaminergic function has been published so far. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 12, 2023 Category: Neurology Authors: Maria Paula C. Azevedo, Camila C. Lobo, Gabriel S. Schmitt, Paula C.A.A.P. Matos, Orlando G.P. Barsottini, Jos é Luiz Pedroso, Wilson Marques, Juliana Pasquotto Souza, Bárbara J. Amorim, Marcondes C. França Tags: Short communication Source Type: research
MRgFUS of the nucleus ventralis intermedius in essential tremor modulates functional connectivity within the classical tremor network and beyond
Magnetic resonance-guided focused ultrasound (MRgFUS) of the thalamic ventral intermediate nucleus is an incisionless lesional treatment for essential tremor. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 11, 2023 Category: Neurology Authors: Christine Kindler, Neeraj Upadhyay, Veronika Purrer, Frederic Carsten Schmeel, Valeri Borger, Lukas Scheef, Ullrich W üllner, Henning Boecker Source Type: research
