Omics profile of iPSC-derived astrocytes from Progressive Supranuclear Palsy (PSP) patients

Progressive Supranuclear Palsy (PSP) is a neurodegenerative tauopathy and, to date, the pathophysiological mechanisms in PSP that lead to Tau hyperphosphorylation and neurodegeneration are not clear. In some brain areas, Tau pathology in glial cells appears to precede Tau aggregation in neurons. The development of a model using astrocyte cell lines derived from patients has the potential to identify molecules and pathways that contribute to early events of neurodegeneration. We developed a model of induced pluripotent stem cells (iPSC)-derived astrocytes to investigate the pathophysiology of PSP, particularly early events that might contribute to Tau hyperphosphorylation, applying omics approach to detect differentially expressed genes, metabolites, and proteins, including those from the secretome.

Source: Parkinsonism and Related Disorders - September 16, 2023 Category: Neurology Authors: Felipe G. Ravagnani, Hellen P. Valerio, Jersey H.S. Mau és, Arthur N. de Oliveira, Renato D. Puga, Karina Griesi-Oliveira, Fabíola R. Picosse, Henrique B. Ferraz, Rodrigo R. Catharino, Graziella E. Ronsein, Patrícia de Carvalho Aguiar Source Type: research