TMEM106B aggravates symptoms of Parkinson ’s disease by regulating the autophagy-lysosome pathway
Background: TMEM106B, a gene encoding a lysosome membrane protein, is tightly related to brain aging and neurogenerative diseases, including Parkinson's disease (PD). Recently, TMEM106B mutations have been reported as genetic risk factors for PD. However, whether TMEM106B plays a major role in pathological neurodegeneration in PD has not yet been investigated. In the present study, we aimed to detect the role and mechanism of TMEM106B in PD models. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Xie, Y. Liu Source Type: research
TGF- β1 Provides Neuroprotection via Inhibition of Microglial Activation in 3-Acetylpyridine-Induced Cerebellar Ataxia Model Rats
Background: Cerebellar ataxias (CAs) consist of a heterogeneous group of neurodegenerative diseases hallmarked by motor deficits and deterioration of the cerebellum and its associated circuitries. Neuroinflammatory responses are present in CA brain, but how neuroinflammation may contribute to CA pathogenesis remain unresolved. Here, we investigate whether transforming growth factor (TGF)- β1, which possesses anti-inflammatory and neuroprotective properties, can ameliorate the microglia-mediated neuroinflammation and thereby alleviate neurodegeneration in CA. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: B.-B. Cao, Z. Liu, Y.-P. Peng Source Type: research
NOX1 triggers ferroptosis and ferritinophagy, contributing to neurodegeneration
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain, accompanied by the accumulation of α-synuclein aggregates. The involvement of ferroptosis, a recently identified form of cell death, has been implicated in various neurodegenerative conditions, including PD. Nevertheless, the specific genes responsible for PD-associated ferroptosis and the most effective therapeutic strategies are s till not fully understood. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Wang Source Type: research
TREM2 deficiency aggravates neuroinflammatory response and cognitive impairment via disease-associated microglia in Parkinson ’s disease
This study explored whether TREM2 regulated the phenotype of disease-related microglia (DAM) and plays a protective role in the cognitive impairment in PD, and its mechanism. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: P. Zhang, Y. Zhang Source Type: research
Treg Cells Attenuate Neuroinflammation and Protect Neurons in a Mouse Model of Parkinson's Disease
Background: Regulatory Tcells (Tregs), which secrete transforming growth factor (TGF)- β and interleukin (IL)-10, have essential role in anti-inflammatory and neurotrophic functions. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y. Huang, Z. Liu, Y.-P. Peng Source Type: research
Dopamine receptor D2 on CD4+ T cells is protective against neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease
Background: Parkinson's disease (PD) is a chronic neurodegenerative disease. Recently, neuroinflammation driven by CD4+ T cells has been involved in PD pathophysiology. Human and murine lymphocytes express all the five subtypes of dopamine receptors (DRs), DRD1 to DRD5. However, roles of DRs particularly DRD2 expressed on CD4+ T cells in PD remain elucidated. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y.-H. Qiu, Z. Liu, Y.-P. Peng Source Type: research
Two parallel nigrostriatal subcircuits mediate arousal effect of dopaminergic neurons in substantia nigra pars compacta
This study systematically investigates the role of dopaminergic (DA) neurons in SNc in wakefulness-sleep regulation and delves into the circuit mechanisms, aiming to provide new clues for the pathogenesis of EDS in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Liu, J. Li, Z. Hu, S. Ren, N. Xiong Source Type: research
Optimizing CNS-Delivery by Lactyl Stearate-Coupled Liposomes
Background: Meningitis is inflammation of tissues which covers brain& spinal cord. Brain drug targeting brings a healthy skepticism to the study of BBB, which is the most frustrating obstacle for pharmacologists wishing to find treatments for brain disorders. The BBB restricts brain uptake of many valuable hydrophilic drugs and limits their efficacy in the treatment of brain diseases. Thus Lactyl stearate(LS) coupled liposomes bearing rifampicin is used for effective management of meningitis. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Bhargava, S. Bhargava Source Type: research
Fibrinogen exacerbates GCase ubiquitination via ATF5-induced TRIP12 activation in Parkinson's Disease
Background: Blood-brain-barrier disruption occurs in Parkinson's disease (PD), which may be accompanied with the deposition of Fibrinogen (FG) in brain parenchyma. However, the relationship between FG and glucocerebrosidase (GCase) reduction, which may contribute to α-synuclein aggregation in PD, is under investigation. Recently, there is evidence that PD patients without GBA mutation also exhibits GCase reduction in brain, and Thyroid-Hormone-Receptor-Interactor-12 (TRIP12) was found to be a key ubiquitin enzyme of GCase degradation. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Zhong, Q. Wang, Z. Huang Source Type: research
Unveiling Cholinergic Brain changes associated with Visuo-Constructive Deficits in Parkinson's Disease: A Focus on the Hooper Test
This study aims to explore the cholinergic neural correlates, using the presynaptic vesicular acetylcholine transporter (V AChT) tracer [18F]Fluoroethoxybenzovesamicol ([18F]FEOBV), of visuo-spatial and visuoconstructive deficits as evaluated by the Hooper test. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. van Emde Boas, G. Carli, P. Kanel, T. Brown, S. Roytman, R. Albin, P. Scott, N. Bohnen Source Type: research
Impaired contrast sensitivity performance in freezers and fallers in Parkinson ’s disease
We examined the relationship between postural instability and gait difficulties and contrast sensitivity in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: T. Brown, M. van Emde Boas, G. Carli, A. Griggs, C. Pongmala, R. Albin, N. Bohnen Source Type: research
Time perception reflects individual differences in motor and non-motor symptoms of Parkinson ’s disease
Background: Decreasing dopaminergic function is at the core of Parkinson ’s disease (PD) motor symptoms and changes in dopaminergic action are associated with many comorbid non-motor symptoms in PD. Notably, dopaminergic signaling in the striatum has been shown to play a critical role in the perception of time. We hypothesize that patients with PD perceive time differe ntly and in accordance with their specific comorbid non-motor symptoms and clinical state. This means that individual differences in clinical symptoms may be reflected in individual differences in timing behavior. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: K. Kishida Source Type: research
Selective Brain Iron Deposition in Individuals with a History of Methamphetamine Abuse
Background: Methamphetamine (meth) abuse is a pervasive public health issue with well-documented neurotoxic effects on the central nervous system. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: L. Kelley, S. Jamall, K. Frei, O. Diamreyan, V. Ravi, Z. Behrooj, T. Wilson, K. Tong Source Type: research
Multidimensional factors can affect the Sexual Health of men with Parkinson's disease
Background: Sexual health (SH) is influenced by several biological, mental, and social factors that may be negatively impacted by PD. Despite its prevalence and relevance for quality of life, the factors that affect the SH in men with Parkinson's disease (MwPD) are still poorly understood, and research in this area is scarce. Thus, the aim of this study was to investigate the impact of motor, non-motor, and social aspects on the SH in MwPD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M.E. Pimentel Piemonte, B. Rafael Antunes Souza, K. Cirilo Costa N óbrega, R. Amorim Gonçalves, T. Silva Martins, G. Ferreira Santos, A. Helene Frazão, A. Roque, I. Almeida Pereira da Silva Nascimento Source Type: research
Multidimensional factors can affect the sexual health of women living with Parkinson's disease
Background: Sexual dysfunction (SD) is a common non-motor symptom (NMS) in people with Parkinson ’s disease (PwPD). Sexual health (SH) depends on several biological, mental, and social factors that PD may affect. Despite its prevalence and relevance for quality of life, SD in women with Parkinson's disease (WwPD) is poorly understood, and research in this area is scarce. Thus, the aim of this study was to investigate the impact of motor, non-motor, and social aspects on the SH of WwPD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M.E. Pimentel Piemonte, K. Cirilo da Costa Nobre, I. Nascimento, B. Rafael Antunes Souza, R. Amorim Gon çalves, T. Silva Martins, G. Ferreira Santos, A. Helene Frazão, A. Roque Source Type: research
