The cingulate island sign in a mixed memory clinical cohort: Prevalence and diagnostic accuracy
Visual rating of the cingulate island sign (CIS) on [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) has a high specificity for dementia with Lewy bodies (DLB) in selected cohorts such as DLB versus Alzheimer's disease (AD). In a mixed memory clinical population this study aimed to uncover the prevalence of CIS, the diagnostic accuracy for DLB, and the relationship between CIS and disease severity. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 2, 2024 Category: Neurology Authors: Linda Ruohua Feng, Gunhild Waldemar, Steen Gregers Hasselbalch, Asmus Vogel, Otto M ølby Henriksen, Ian Law, Kristian Steen Frederiksen Source Type: research
Thyroid disease and cervical dystonia
We thank Kizilkilic and colleagues for their comments on our recent article, where we described a higher frequency of thyroid disease among individuals with cervical dystonia compared to neurological controls [1]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - March 2, 2024 Category: Neurology Authors: G. Kilic-Berkmen, L.M. Scorr, G. Defazio, H.A. Jinnah Tags: Correspondence Source Type: research
Is Dystonia an Immunologic Disorder?
Immunologic mechanisms are increasingly implicated in a variety of movement disorders. In addition to well established immunologically mediated movement disorders, such as Sydenham chorea, there are many autoimmune disorders manifested by a variety of hyperkinetic disorders, including chorea, myoclonus, and dystonia [1]. Even in hypokinetic disorders, such as Parkinson ’s disease and other forms of parkinsonism, immunologic mechanisms have been found to play an important pathogenic role [2]. In one recent metanalysis of 2,663 patients with autoimmune encephalitis, 40% had some type of a movement disorder [3]. (Source: Pa...
Source: Parkinsonism and Related Disorders - February 29, 2024 Category: Neurology Authors: Joseph Jankovic Source Type: research
Post-COVID parkinsonism: A scoping review
The clinical features and outcomes of post-COVID parkinsonism have not been organized systematically, and the possible correlations between COVID-19 and parkinsonism have not been elucidated. This scoping review addresses these two unmet needs. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 28, 2024 Category: Neurology Authors: Paola Polverino, Antoniangela Cocco, Alberto Albanese Tags: Review article Source Type: research
Convention vs. Innovation I: Digital technology will replace clinic-based care in Parkinson disease
The Parkinson Study Group (PSG) gathered North American experts in Parkinson disease (PD) during the 9th Annual Symposium on Shaping the Management of Parkinson Disease: Debating Current Controversies. Debaters were tasked with agree or disagree positions to a particular prompt. This is the first in the two-part series of “Convention vs. Innovation” debates involving current trends and advances in Parkinson disease. With the prompt of “Digital technology will replace clinic-based care in PD,” Dr. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 28, 2024 Category: Neurology Authors: Ruth B. Schneider, Oliver Phillips, Lorraine Kalia Source Type: research
Mood disturbances in newly diagnosed Parkinson's Disease patients reflect intrathecal inflammation
In Parkinson's disease (PD), neuroinflammation may be involved in the pathogenesis of mood disorders, contributing to the clinical heterogeneity of the disease.The cerebrospinal fluid (CSF) levels of interleukin (IL)-1 β, IL-2, IL-6, IL-7, IL-8, IL-9, IL-12, IL-17, interferon (IFN)γ, macrophage inflammatory protein 1-alpha (MIP-1a), MIP-1b, granulocyte colony stimulating factor (GCSF), eotaxin, tumor necrosis factor (TNF), and monocyte chemoattractant protein 1 (MCP-1), were assessed in 45 newly diagnosed and un treated PD patients and in 44 control patients. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 27, 2024 Category: Neurology Authors: Mario Stampanoni Bassi, Luana Gilio, Giovanni Galifi, Fabio Buttari, Ettore Dolcetti, Antonio Bruno, Lorena Belli, Nicola Modugno, Roberto Furlan, Annamaria Finardi, Georgia Mandolesi, Alessandra Musella, Diego Centonze, Enrica Olivola Source Type: research
Melanopsin retinal ganglion cell function in Alzheimer's vs. Parkinson's disease an exploratory meta-analysis and review of pupillometry protocols
Neurodegenerative diseases share retinal abnormalities. Chromatic pupillometry allows in vivo assessment of photoreceptor functional integrity, including melanopsin-expressing retinal ganglion cells. This exploratory meta-analysis assesses retinal photoreceptor functionality in Alzheimer's vs. Parkinson's disease and conducts an in-depth review of applied pupillometric protocols. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 27, 2024 Category: Neurology Authors: Oliver Leopold Steiner, Jan de Zeeuw Tags: Review article Source Type: research
Mapping brain metabolism, connectivity and neurotransmitters topography in early and late onset dementia with lewy bodies
Early-onset dementia with Lewy bodies (EO-DLB) is associated with rapid cognitive decline and severe neuropsychiatric symptoms at onset. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 26, 2024 Category: Neurology Authors: Silvia Paola Caminiti, Alice Galli, Lorenzo Jonghi-Lavarini, Cecilia Boccalini, Nicolas Nicastro, Arturo Chiti, Valentina Garibotto, Daniela Perani Source Type: research
Longitudinal brain changes in Parkinson's disease with severe olfactory deficit
This study aimed to examine longitudinal cortical atrophy and thinning in early-stage PD with severe olfactory deficit (anosmia) without and with concurrent probable RBD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 26, 2024 Category: Neurology Authors: Kazuya Kawabata, Epifanio Bagarinao, Klaus Seppi, Werner Poewe Tags: Short communication Source Type: research
SQSTM1 Pro392Leu presenting as a corticobasal syndrome with progressive nonfluent aphasia
We report a 57-year-old right-handed-woman with a history of progressive speech impairment, marked right side rigidity and bradykinesia, with rest tremor and stimulus sensitive myoclonus. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 22, 2024 Category: Neurology Authors: Miguel T ábuas-Pereira, Marisa Lima, Catarina Bernardes, João Durães, Diana Duro, Inês Baldeiras, António Freire-Gonçalves, Ana Morgadinho, Isabel Santana, Maria Rosário Almeida Tags: Correspondence Source Type: research
Exploring obstructive sleep apnea and sleep architecture in Parkinson's disease motor subtypes
This study aimed to assess differences in sleep structure and obstructive sleep apnea (OSA) between the PIGD and non-PIGD subtypes. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 22, 2024 Category: Neurology Authors: Amanda Scanga, Andrea Benedetti, R John Kimoff, Anne-Louise Lafontaine, Ann Robinson, Marianne Gingras, Marta Kaminska Source Type: research
“Advanced” Parkinson's disease: A review
There is no consensus driven definition of “advanced” Parkinson's disease (APD) currently. APD has been described in terms of emergence of specific clinical features and clinical milestones of the disease e.g., motor fluctuations, time to increasing falls, emergence of cognitive decline, etc. The pathological burden of disease has been u sed to characterize various stages of the disease. Imaging markers have been associated with various motor and nonmotor symptoms of advancing disease. In this review, we present an overview of clinical, pathologic, and imaging markers of APD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 22, 2024 Category: Neurology Authors: Sana Aslam, Fredric Manfredsson, Ashley Stokes, Holly Shill Tags: Review article Source Type: research
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(Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 21, 2024 Category: Neurology Source Type: research
Getting an earful of stimulation: A novel means for neuromodulation of Parkinson disease
Beyond medications, selective lesioning or electrically stimulating brain regions have become established treatment modalities for Parkinson disease (PD), providing alternatives for improving upon the disabilities of advanced PD. These approaches alter brain circuitry differently than that accomplished by neurotransmitter manipulations achieve symptom relief. Though dopaminergic therapy continues to be the mainstay of PD therapeutics, new approaches to neuromodulating neuronal connections are now joining the decades-old option of regional deep brain stimulation. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 19, 2024 Category: Neurology Authors: Peter A. LeWitt Source Type: research
Exploration of potential immune mechanisms in cervical dystonia
Although there are many possible causes for cervical dystonia (CD), a specific etiology cannot be identified in most cases. Prior studies have suggested a relationship between autoimmune disease and some cases of CD, pointing to possible immunological mechanisms. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 16, 2024 Category: Neurology Authors: Laura M. Scorr, Gamze Kilic-Berkmen, Diane J. Sutcliffe, Ashok R. Dinasarapu, J. Lucas McKay, Pritha Bagchi, Michael D. Powell, Jeremy M. Boss, Nezih Cereb, Marian Little, Loren Gragert, John Hanfelt, Andrew McKeon, William Tyor, H.A. Jinnah Source Type: research
