Beneficial effects of activity level on striatal binding: careful replication is required

The spotlight article by Jin et al. [1] supports a previous publication analyzing the PPMI database showing that physical activity may modify disease progression for people with Parkinson ’s disease [2]. The finding is also quite consistent with three studies that have all suggested that six months of high intensity endurance exercise shows a reduced rate of decline in the MDS-UPDRS part III in comparison to moderate intensity exercise [3-5]. The present study adds to these finding s by showing a reduced decline in dopamine uptake over time in people with Parkinson’s disease that is related to physical activity.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research