GSE261004 Gene expression profiles of cells from PDOs of normal colon and colorectal cancers [RNA-Seq]
Contributors : Molong Qu ; Liang XiongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPhenotypic plasticity is a major driver of cancer progression, metastasis, and treatment resistance. However, the principles governing human cancer plasticity associated with poor prognosis remain poorly understood due to the lack of in vitro models. Here we identified a unique cancer cell state at single-cell resolution to predict poor prognosis across several human cancers with different clinical features, especially colorectal cancer (CRC) progression and metastasis, named the poor prognostic pl...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Cancers, Vol. 16, Pages 1532: Lysine Methyltransferase 9 (KMT9) Is an Actionable Target in Muscle-Invasive Bladder Cancer
In this study, we show that KMT9 regulates proliferation, migration, and invasion of various MIBC cell lines with different genetic mutations. KMT9α depletion results in the differential expression of genes regulating the cell cycle, cell adhesion, and migration. Differentially expressed genes include oncogenes such as EGFR and AKT1 as well as mediators of cell adhesion or migration such as DAG1 and ITGA6. Reduced cell proliferation upon KMT9α depletion is also observed in Pten/Trp53 knockout bladder tumor organoids, which cannot be rescued with an enzymatically inactive KMT9α muta...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Sainab Totonji Anna Ramos-Triguero Dominica Willmann Manuela Sum Sylvia Urban Helena Bauer Astrid Rieder Sheng Wang Holger Greschik Eric Metzger Roland Sch üle Tags: Article Source Type: research
Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach
In this study, we included four crucial proteins that perform signalling, receptor, and regulatory action, namely- NUDIX Hydrolases, Dihydrofolate Reductase, HER2/neu Kinase and EGFR and performed multitargeted molecular docking studies against human-approved drugs using HTVS, SP and extra precise algorithms and filtered the poses with MM\GBSA, suggested a benzodiazepine derivative chlordiazepoxide, used as an anxiolytic agent, can be a multitargeted inhibitor with docking and MM\GBSA score ranging from − 4.628 to − 7.877 and − 18.59 to − 135.86 kcal/mol, respectively, and the most interacted residues were 6ARG, 6G...
Source: Medical Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research
Trends in mortality from gastrointestinal, hepatic, and pancreatic cancers in the United States: A comprehensive analysis (1999-2020)
CONCLUSION: While overall gastrointestinal cancer-related mortality declined significantly in the United States from 1999 to 2020, mortality from some cancers increased. Furthermore, differences between sexes and racial groups underscore crucial differences in gastrointestinal cancer mortality, highlighting areas for future research.PMID:38623490 | PMC:PMC11017855 | DOI:10.1002/jgh3.13064 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Hassam Ali Rizwan Ishtiaq Brandon Tedder Joshua Zweigle Romina Nomigolzar Dushyant S Dahiya Vishali Moond Amir Humza Sohail Pratik Patel Debargha Basuli Hans L Tillmann Source Type: research
Urolithin A affects cellular migration and modulates matrix metalloproteinase expression in colorectal cancer cells
Cell Biochem Funct. 2024 Apr;42(3):e4019. doi: 10.1002/cbf.4019.ABSTRACTColorectal cancer (CRC) is the world's second most common gastrointestinal malignancy. Preventing tumor cell proliferation and dissemination is critical for patient survival. Polyphenols have a variety of health advantages and can help prevent cancer. The current study examined different cellular activities of the gut-microbiota metabolite urolithin A (UA) on several colon cancer cell lines. The results revealed that UA suppressed cell growth in a dose- and time-dependent manner. In the current investigation, UA substantially affected cell migration in...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Mohammad S El-Wetidy Mohamad I Rady Islam Rady Hamed Helal Source Type: research
Reply to the letter to the editor regarding “A prospective randomized study of multimodal analgesia combined with single injection transversus abdominis plane block versus epidural analgesia against postoperative pain after laparoscopic colon cancer surgery”
(Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 16, 2024 Category: Gastroenterology Source Type: research
Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models
RAD54 and BLM helicase play pivotal roles during homologous recombination repair (HRR) to ensure genome maintenance. BLM amino acids (aa 181–212) interact with RAD54 and enhance its chromatin remodeling activity. Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin, and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mouse models. ChIP-Seq analysis and validation revealed increased BLM and RAD54 corecruitment on the MRP2 promoter in camptothecin...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Ekjot Kaur, Ritu Agrawal, Rimpy Arun, Vinoth Madhavan, Vivek Srivastava, Dilip Kumar, Pragyan Parimita Rath, Nitin Kumar, Sreekanth Vedagopuram, Nishant Pandey, Swati Priya, Patrick Legembre, Samudrala Gourinath, Avinash Bajaj, Sagar Sengupta Source Type: research
Surgical Decision-Making in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Aug 10;37(3):191-197. doi: 10.1055/s-0043-1770732. eCollection 2024 May.ABSTRACTFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostom...
Source: Hand Surgery - April 15, 2024 Category: Surgery Authors: Allie E Steinberger Maggie L Westfal Paul E Wise Source Type: research
An arresten-derived anti-angiogenic peptide triggers apoptotic cell death in endothelial cells
CONCLUSIONS: It might be suggested that Ars induced apoptosis in endothelial cells through the mitochondrial pathway and had no effect on the cell cycle. Besides, Ars induced apoptosis significantly in vivo. However, further studies are required to confirm the detailed molecular mechanism of Ars, this peptide has the potential to be optimized for clinical translations.PMID:38622345 | DOI:10.1007/s11033-024-09448-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Reyhane Chamani Omid Saberi Fatemeh Fathinejad Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
Effects of nucleoside analogues, lipophilic prodrugs and elaidic acids on core signaling pathways in cancer cells
CONCLUSIONS: The findings suggest that both parent drugs, prodrugs, and the EA chain influence cell survival and signaling pathways.PMID:38619266 | DOI:10.1080/15257770.2024.2339952 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - April 15, 2024 Category: Biochemistry Authors: Marika A Fra ńczak Claudine van der Sande Elisa Giovannetti Godefridus J Peters Source Type: research
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361.ABSTRACTInvasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsie...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Malte Gronewold Isabel Grote Stephan Bartels Henriette Christgen Leonie D Kandt Maria Jose Brito G àbor Cserni Maximilian E Daemmrich Franz Fogt Burkhard M Helmke Natalie Ter Hoeve Corinna Lang-Schwarz Michael Vieth Axel Wellmann Elna Kuehnle Ulf Kulik G Source Type: research
The prognostic biomarker TPGS2 is correlated with immune infiltrates in pan-cancer: a bioinformatics analysis
CONCLUSIONS: TPGS2 is aberrantly expressed in most cancer tissues and might be associated with immune cell infiltration in the tumor microenvironment. TPGS2 could serve not only as a biomarker for predicting clinical outcomes, but also as a promising biomarker for evaluating and developing new approaches to immunotherapy in many types of cancers, especially colon adenocarcinoma and stomach adenocarcinoma.PMID:38617524 | PMC:PMC11009813 | DOI:10.21037/tcr-23-113 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Zujun Ding Qing Ding Hang Li Source Type: research
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361.ABSTRACTInvasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsie...
Source: Clinical Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Malte Gronewold Isabel Grote Stephan Bartels Henriette Christgen Leonie D Kandt Maria Jose Brito G àbor Cserni Maximilian E Daemmrich Franz Fogt Burkhard M Helmke Natalie Ter Hoeve Corinna Lang-Schwarz Michael Vieth Axel Wellmann Elna Kuehnle Ulf Kulik G Source Type: research
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361.ABSTRACTInvasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsie...
Source: Clinical Genitourinary Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Malte Gronewold Isabel Grote Stephan Bartels Henriette Christgen Leonie D Kandt Maria Jose Brito G àbor Cserni Maximilian E Daemmrich Franz Fogt Burkhard M Helmke Natalie Ter Hoeve Corinna Lang-Schwarz Michael Vieth Axel Wellmann Elna Kuehnle Ulf Kulik G Source Type: research
