Radiosensitizing effects of heparinized magnetic iron oxide nanoparticles in colon cancer
Biomed Pharmacother. 2024 May 2;175:116668. doi: 10.1016/j.biopha.2024.116668. Online ahead of print.ABSTRACTThe combination of radiation treatment and chemotherapy is currently the standard for management of cancer patients. However, safe doses do not often provide effective therapy, then pre-treated patients are forced to repeat treatment with often already increased tumor resistance to drugs and irradiation. One of the solutions we suggest is to improve primary course of radiation treatment via enhancing radiosensitivity of tumors by magnetic-guided iron oxide nanoparticles (magnetite). We obtained spherical heparinized...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 3, 2024 Category: Drugs & Pharmacology Authors: Maria V Shestovskaya Anna L Luss Olga A Bezborodova Pavel P Kulikov Daria A Antufrieva Ekaterina A Plotnikova Valentin V Makarov Vladimir S Yudin Andrey A Pankratov Anton A Keskinov Source Type: research
Structural and functional characteristics of pectins from three cultivars of apple (Malus pumila Mill.) pomaces
This study aimed to investigate the chemical composition, structural properties, and biological properties of pectin polysaccharides (AP-FS, AP-QG, and AP-HG) isolated from different varieties of apple pomace. Based on the methylation and nuclear magnetic resonance analyses, the structure of AP-FS was determined to be composed of an α-1,4-linked homogalacturonan backbone that exhibited high levels of O-6 methylation. All pectins exhibit potent inhibitory activity against human colon cancer and human liver cancer cells, along with immunostimulatory effects. Among them, AP-FS exhibited the highest activity level. Finally, w...
Source: International Journal of Biological Macromolecules - May 3, 2024 Category: Biochemistry Authors: Huan Guo Hang Li Wenyi Ran Wenyue Yu Yue Xiao Renyou Gan Hong Gao Source Type: research
Macromolecules with predominant β-pleated sheet proteins in extracellular vesicles released from Raphanus sativus L. var. caudatus Alef microgreens induce DNA damage-mediated apoptosis in HCT116 colon cancer cells
Int J Biol Macromol. 2024 May 1;269(Pt 1):132001. doi: 10.1016/j.ijbiomac.2024.132001. Online ahead of print.ABSTRACTPlant-derived bioactive macromolecules (i.e., proteins, lipids, and nucleic acids) were prepared as extracellular vesicles (EVs). Plant-derived EVs are gaining pharmaceutical research interest because of their bioactive components and delivery properties. The spherical nanosized EVs derived from Raphanus sativus L. var. caudatus Alef microgreens previously showed antiproliferative activity in HCT116 colon cancer cells from macromolecular compositions (predominantly proteins). To understand the mechanism of a...
Source: International Journal of Biological Macromolecules - May 3, 2024 Category: Biochemistry Authors: Karnchanok Kaimuangpak Reny Rosalina Kanjana Thumanu Natthida Weerapreeyakul Source Type: research
A nomogram to predict the risk of venous thromboembolism in patients with colon cancer in China
ConclusionsWe have established and validated a nomogram to predict the VTE risk of colon cancer patients in China, which encompasses a diverse age range, a significant population size, and various clinical factors. It facilitates the identification of high-risk groups and may enable the implementation of targeted preventive measures. (Source: Cancer Medicine)
Source: Cancer Medicine - May 3, 2024 Category: Cancer & Oncology Authors: Yuanyuan Yang,
Jiayi Zhan,
Xiaosheng Li,
Jun Hua,
Haike Lei,
Xiaoliang Chen Tags: RESEARCH ARTICLE Source Type: research
Molecules, Vol. 29, Pages 2119: Verification of In Vitro Anticancer Activity and Bioactive Compounds in Cordyceps Militaris-Infused Sweet Potato Shochu Spirits
This study aims to verify in vitro anticancer activity and bioactive compounds in shochu spirits infused with Cordyceps militaris, a Chinese medicine. The results revealed that a bioactive fraction was eluted from the spirit extract with 40% ethanol. The infusion time impacted the inhibitory effect of the spirit extract on the proliferation of colon cancer-derived cell line HCT-116 cells, and a 21-day infusion showed the strongest inhibitory effect. Furthermore, the spirit extract was separated into four fractions, A-D, by high-performance liquid chromatography (HPLC), and Fractions B, C, and D, but not A, exerted the effe...
Source: Molecules - May 3, 2024 Category: Chemistry Authors: Kozue Sakao Cho Sho Takeshi Miyata Kensaku Takara Rio Oda De-Xing Hou Tags: Article Source Type: research
Fertility drugs and cancer: a guideline
Methodological limitations in studying the association between the use of fertility drugs and cancer include the inherent increased risk of cancer in women who never conceive, the increased risk of cancer because of factors (endometriosis and unopposed estrogen) associated with infertility, the low incidence of most of these cancers, and that the diagnosis of cancer is typically several years after fertility drug use. On the basis of available data, there does not appear to be an association between fertility drugs and breast, colon, or cervical cancer. (Source: Fertility and Sterility)
Source: Fertility and Sterility - May 3, 2024 Category: Reproduction Medicine Authors: Practice Committee of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research
Concurrent ascending colon adenocarcinoma and colonic tuberculosis: a case report from Syria
CONCLUSION: The two diseases may co-exist; thus, diagnosing them may not be the easiest, not to mention the lack of a clear treatment protocol in case of their accompany.PMID:38694366 | PMC:PMC11060274 | DOI:10.1097/MS9.0000000000001927 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Basel Ahmad Suzana Durra Sabine Tayfour Sandra Habka Bassel Albatal Mohamad Ahmad Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
Functionalized liposomes as a potential drug delivery systems for colon cancer treatment: A systematic review
Int J Biol Macromol. 2024 Apr 30:132023. doi: 10.1016/j.ijbiomac.2024.132023. Online ahead of print.ABSTRACTColon cancer is one of the lethal diseases in the world with approximately 700,000 fatalities annually (Abdulzehra et al., 2023 [1]). Nowadays, due to the side effects of existing methods in the treatment of colon cancer such as radiotherapy and chemotherapy, the use of targeted nanocarriers in cancer treatment has received wide attention, and among them, especially liposomes have been studied a lot. Based on this, anti-tumor drugs hidden in targeted active liposomes can selectively act on cancer cells. In this syste...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Eskandar Moghimipour Somayeh Handali Source Type: research
Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
CONCLUSION: The results indicated that the 5-FU + DOX combination therapy induces apoptosis and renders 5-FU and DOX more effective at lower concentrations compared to their alone use. This study reveals promising results in reducing the potential side effects of treatment by enabling the use of lower drug doses.PMID:38698270 | DOI:10.1007/s11033-024-09562-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 2, 2024 Category: Molecular Biology Authors: Sema Bilgin Source Type: research
Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
CONCLUSION: The results indicated that the 5-FU + DOX combination therapy induces apoptosis and renders 5-FU and DOX more effective at lower concentrations compared to their alone use. This study reveals promising results in reducing the potential side effects of treatment by enabling the use of lower drug doses.PMID:38698270 | DOI:10.1007/s11033-024-09562-x (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 2, 2024 Category: Molecular Biology Authors: Sema Bilgin Source Type: research
Concurrent ascending colon adenocarcinoma and colonic tuberculosis: a case report from Syria
CONCLUSION: The two diseases may co-exist; thus, diagnosing them may not be the easiest, not to mention the lack of a clear treatment protocol in case of their accompany.PMID:38694366 | PMC:PMC11060274 | DOI:10.1097/MS9.0000000000001927 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Basel Ahmad Suzana Durra Sabine Tayfour Sandra Habka Bassel Albatal Mohamad Ahmad Source Type: research
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4
Pharmacol Rev. 2024 May 2;76(3):388-413. doi: 10.1124/pharmrev.123.000901.ABSTRACTThe involvement of the prostaglandin E2 (PGE2) system in cancer progression has long been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with pleiotropic effects in the human body. High levels of intratumoral PGE2 and overexpression of the key metabolic enzymes of PGE2 have been observed and suggested to contribute to tumor progression. This has been claimed for different types of solid tumors, including, but not limited to, lung, breast, and colon cancer. PGE2 has direct effects on tumor cells and angiogenesis th...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Ana Santiso Akos Heinemann Julia Kargl Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
