Epithelial-mesenchymal interaction protects normal colonocytes from 4-HNE-induced phenotypic transformation
ConclusionsDuring the exposure phase, the epithelial-mesenchymal interaction protected colonocytes from 4-HNE-induced phenotypic transformation via activation of the BMP pathway. This intercellular dialogue also limited the ability of fibroblasts to subsequently promote colonocyte-anchorage-independent growth. In contrast, fibroblasts pre-exposed to 4-HNE in monoculture strongly increased the ability of Co(m) colonocytes to form colonies. (Source: PLoS One)
Source: PLoS One - April 26, 2024 Category: Biomedical Science Authors: Jacques Dupuy Source Type: research
Prognostic factors in pulmonary metastases resection from colorectal cancer: impact of right-sided colon cancer and early recurrence
ConclusionThe RCC and early recurrence after PM resection were poor prognosis factors of OS. Higher value of CEA before PM resection was an independent risk factor for early recurrence after resection of PM. Comparitive study between surgery and nonsurgery is necessary in patients with higher CEA values. (Source: General Thoracic and Cardiovascular Surgery)
Source: General Thoracic and Cardiovascular Surgery - April 26, 2024 Category: Cardiovascular & Thoracic Surgery Source Type: research
Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2024
Endoscopy DOI: 10.1055/a-2304-3219
1 ESGE recommends cold snare polypectomy (CSP), to include a clear margin of normal tissue (1–2 mm) surrounding the polyp, for the removal of diminutive polyps (≤ 5 mm).Strong recommendation, high quality of evidence.
2 ESGE recommends against the use of cold biopsy forceps excision because of its high rate of incomplete resection.Strong recommendation, moderate quality of evidence.
3 ESGE recommends CSP, to include a clear margin of normal tissue (1–2 mm) surrounding the polyp, for the removal of small polyps (6–9 mm).Strong recommendation, high qua...
Source: Endoscopy - April 26, 2024 Category: Gastroenterology Authors: Ferlitsch, Monika Hassan, Cesare Bisschops, Raf Bhandari, Pradeep Dinis-Ribeiro, M ário Risio, Mauro Paspatis, Gregorios A. Moss, Alan Lib ânio, Diogo Lorenzo-Z úñiga, Vincente Voiosu, Andrei M. Rutter, Matthew D. Pellis é, Maria Moons, Leon M. G. Pr Tags: Guideline Source Type: research
Correction: Circ_0055625 knockdown inhibits tumorigenesis and improves radiosensitivity by regulating miR-338-3p/MSI1 axis in colon cancer
(Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Chao Gao, Yi Zhang, Yanming Tian, Chun Han, Lan Wang, Boyue Ding, Hua Tian, Chaoxi Zhou, Yingchao Ju, Ale Peng and Qiyao Yu Tags: Correction Source Type: research
Exploring the multifaceted bioactivities of < em > Lavandula pinnata L. < /em > essential oil: promising pharmacological activities
This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from the Canary Islands, traditionally used in treating various ailments. Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity was assessed by DPPH radical scavenging and total antioxidant capacity assays. Antimicrobial activity was evaluated by disc diffusion, MIC, MBC, and MFC determination against bacterial (Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa) and fungal (Candida glabrata, Rhodotorula glutinis, Aspergillus nige...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Mounir Haddou Amine Elbouzidi Mohamed Taibi Abdellah Baraich El Hassania Loukili Reda Bellaouchi Ennouaamane Saalaoui Abdeslam Asehraou Ahmad Mohammad Salamatullah Mohammed Bourhia Hiba-Allah Nafidi Mohamed Addi Bouchra El Guerrouj Khalid Chaabane Source Type: research
Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines
Conclusion: We found that miR-92a-3p does not upregulate the expression of proteins of DNA-repair pathways and other genes involved in FOLFOX chemotherapy resistance.PMID:38659583 | PMC:PMC11039864 | DOI:10.3389/fphar.2024.1376638 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Paula I Escalante Luis A Qui ñones H éctor R Contreras Source Type: research
Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Int Rev Cell Mol Biol. 2024;385:1-39. doi: 10.1016/bs.ircmb.2023.11.004. Epub 2024 Jan 9.ABSTRACTCancer remains the leading cause of global mortality, prompting a paradigm shift in its treatment and outcomes with the advent of targeted therapies. Among the most prevalent mutations in RAS-driven cancers, Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations account for approximately 86% of cases worldwide, particularly in lung, pancreatic, and colon cancers, contributing to poor prognosis and reduced overall survival. Despite numerous efforts to understand the biology of KRAS mutants and their pivotal role in cancer d...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Prajna Tripathi Rajni Kumari Rajiv Pathak Source Type: research
Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Int Rev Cell Mol Biol. 2024;385:1-39. doi: 10.1016/bs.ircmb.2023.11.004. Epub 2024 Jan 9.ABSTRACTCancer remains the leading cause of global mortality, prompting a paradigm shift in its treatment and outcomes with the advent of targeted therapies. Among the most prevalent mutations in RAS-driven cancers, Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations account for approximately 86% of cases worldwide, particularly in lung, pancreatic, and colon cancers, contributing to poor prognosis and reduced overall survival. Despite numerous efforts to understand the biology of KRAS mutants and their pivotal role in cancer d...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Prajna Tripathi Rajni Kumari Rajiv Pathak Source Type: research
Anti-Anisakis antibodies in colon cancer patients and their relationship with γδ T-cells
Parasitol Res. 2024 Apr 25;123(4):196. doi: 10.1007/s00436-024-08216-y.ABSTRACTMany pathogens are related to carcinogenesis. Chronic inflammation, as a result of persistent infection, leads to DNA damage, higher expression of oncogenes, decreased apoptosis and immunosuppression, which are some of the reasons for cancer induction. Among parasites, Schistosoma, Opistorchis and Clonorchis are recognised as infectious agents which contribute to cancer. A relationship between Anisakis and cancer was hypothesised because cellular responses to Anisakis products could result in inflammation and DNA damage. Previous research has sh...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Juan C Andreu-Ballester Carmen Cu éllar Javier Colmena-Zaragoza Lorena Galindo-Regal Carolina Hurtado-Marcos Juan Gonz ález-Fernández Zutoia Balciscueta Carlos Garc ía-Ballesteros Francisca L ópez-Chuliá Ana I Jim énez Antonio Llombart-Cussac Source Type: research
Correction: Standardization of Colon Resection for Cancer: An Overview of the American College of Surgeons Commission on Cancer Standard 5.6
Ann Surg Oncol. 2024 Apr 25. doi: 10.1245/s10434-024-15331-8. Online ahead of print.NO ABSTRACTPMID:38662097 | DOI:10.1245/s10434-024-15331-8 (Source: Ann Oncol)
Source: Ann Oncol - April 25, 2024 Category: Cancer & Oncology Authors: Katryna K Thomas Amanda B Francescatti Timothy J Vreeland Mediget K Teshome Arden M Morris Kelly K Hunt Matthew H G Katz Anthony M Villano Source Type: research
Helminth-derived molecules improve 5-fluorouracil treatment on experimental colon tumorigenesis
Biomed Pharmacother. 2024 Apr 24;175:116628. doi: 10.1016/j.biopha.2024.116628. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the most prevalent fatal neoplasias worldwide. Despite efforts to improve the early diagnosis of CRC, the mortality rate of patients is still nearly 50%. The primary treatment strategy for CRC is surgery, which may be accompanied by chemotherapy and radiotherapy. The conventional and first-line chemotherapeutic agent utilized is 5-fluorouracil (5FU). However, it has low efficiency. Combination treatment with leucovorin and oxaliplatin or irinotecan improves the effectiveness of 5FU...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: M ónica G Mendoza-Rodríguez Daniela Medina-Reyes Cuauht émoc A Sánchez-Barrera Karen V Fern ández-Muñoz Ver ónica García-Castillo Jorge L Ledesma-Torres Marisol I Gonz ález-González Jos é L Reyes Carlos P érez-Plascencia Miriam Rodr íguez-Sos Source Type: research
Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Int Rev Cell Mol Biol. 2024;385:1-39. doi: 10.1016/bs.ircmb.2023.11.004. Epub 2024 Jan 9.ABSTRACTCancer remains the leading cause of global mortality, prompting a paradigm shift in its treatment and outcomes with the advent of targeted therapies. Among the most prevalent mutations in RAS-driven cancers, Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations account for approximately 86% of cases worldwide, particularly in lung, pancreatic, and colon cancers, contributing to poor prognosis and reduced overall survival. Despite numerous efforts to understand the biology of KRAS mutants and their pivotal role in cancer d...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Prajna Tripathi Rajni Kumari Rajiv Pathak Source Type: research
Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Int Rev Cell Mol Biol. 2024;385:1-39. doi: 10.1016/bs.ircmb.2023.11.004. Epub 2024 Jan 9.ABSTRACTCancer remains the leading cause of global mortality, prompting a paradigm shift in its treatment and outcomes with the advent of targeted therapies. Among the most prevalent mutations in RAS-driven cancers, Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations account for approximately 86% of cases worldwide, particularly in lung, pancreatic, and colon cancers, contributing to poor prognosis and reduced overall survival. Despite numerous efforts to understand the biology of KRAS mutants and their pivotal role in cancer d...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Prajna Tripathi Rajni Kumari Rajiv Pathak Source Type: research
Helminth-derived molecules improve 5-fluorouracil treatment on experimental colon tumorigenesis
Biomed Pharmacother. 2024 Apr 24;175:116628. doi: 10.1016/j.biopha.2024.116628. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the most prevalent fatal neoplasias worldwide. Despite efforts to improve the early diagnosis of CRC, the mortality rate of patients is still nearly 50%. The primary treatment strategy for CRC is surgery, which may be accompanied by chemotherapy and radiotherapy. The conventional and first-line chemotherapeutic agent utilized is 5-fluorouracil (5FU). However, it has low efficiency. Combination treatment with leucovorin and oxaliplatin or irinotecan improves the effectiveness of 5FU...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: M ónica G Mendoza-Rodríguez Daniela Medina-Reyes Cuauht émoc A Sánchez-Barrera Karen V Fern ández-Muñoz Ver ónica García-Castillo Jorge L Ledesma-Torres Marisol I Gonz ález-González Jos é L Reyes Carlos P érez-Plascencia Miriam Rodr íguez-Sos Source Type: research
Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Int Rev Cell Mol Biol. 2024;385:1-39. doi: 10.1016/bs.ircmb.2023.11.004. Epub 2024 Jan 9.ABSTRACTCancer remains the leading cause of global mortality, prompting a paradigm shift in its treatment and outcomes with the advent of targeted therapies. Among the most prevalent mutations in RAS-driven cancers, Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations account for approximately 86% of cases worldwide, particularly in lung, pancreatic, and colon cancers, contributing to poor prognosis and reduced overall survival. Despite numerous efforts to understand the biology of KRAS mutants and their pivotal role in cancer d...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Prajna Tripathi Rajni Kumari Rajiv Pathak Source Type: research
