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Epigenetic therapeutic strategies in pancreatic cancer
Int Rev Cell Mol Biol. 2024;383:1-40. doi: 10.1016/bs.ircmb.2023.10.002. Epub 2024 Jan 24.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies, characterized by its aggressiveness and metastatic potential, with a 5-year survival rate of only 8-11%. Despite significant improvements in PDAC treatment and management, therapeutic alternatives are still limited. One of the main reasons is its high degree of intra- and inter-individual tumor heterogeneity which is established and maintained through a complex network of transcription factors and epigenetic regulators. Epigenetic drugs, have...
Source: International Review of Cell and Molecular Biology - February 15, 2024 Category: Cytology Authors: Arturo Orlacchio Stephen Muzyka Tamas A Gonda Source Type: research

Epigenetics as a determinant of radiation response in cancer
This article reviews recent data on the main molecular mechanisms and signaling pathways related to the biological response to radiotherapy in cancer; highlighting the epigenetic control exerted by DNA methylation, histone marks, chromatin remodeling and m6A RNA methylation on gene expression and activation of signaling pathways related to radiation therapy response.PMID:38359968 | DOI:10.1016/bs.ircmb.2023.07.008 (Source: International Review of Cell and Molecular Biology)
Source: International Review of Cell and Molecular Biology - February 15, 2024 Category: Cytology Authors: Elena Arechaga-Ocampo Source Type: research

Epigenome editing in cancer: Advances and challenges for potential therapeutic options
Int Rev Cell Mol Biol. 2024;383:191-230. doi: 10.1016/bs.ircmb.2023.10.001. Epub 2023 Nov 21.ABSTRACTCancers are diseases caused by genetic and non-genetic environmental factors. Epigenetic alterations, some attributed to non-genetic factors, can lead to cancer development. Epigenetic changes can occur in tumor suppressors or oncogenes, or they may contribute to global cell state changes, making cells abnormal. Recent advances in gene editing technology show potential for cancer treatment. Herein, we will discuss our current knowledge of epigenetic alterations occurring in cancer and epigenetic editing technologies that ca...
Source: International Review of Cell and Molecular Biology - February 15, 2024 Category: Cytology Authors: Seung-Won Lee Connor Mitchell Frankston Jungsun Kim Source Type: research

Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications
Int Rev Cell Mol Biol. 2024;383:41-66. doi: 10.1016/bs.ircmb.2023.06.002. Epub 2023 Jul 7.ABSTRACTProstate cancer is the second most prevalent cancer in men globally. De novo neuroendocrine prostate cancer (NEPC) is uncommon at initial diagnosis, however, (treatment-induced) t-NEPC emerges in up to 25% of prostate adenocarcinoma (PRAD) cases treated with androgen deprivation, carrying a drastically poor prognosis. The transition from PRAD to t-NEPC is underpinned by several key genetic mutations; TP53, RB1, and MYCN are the main genes implicated, bearing similarities to other neuroendocrine tumours. A broad range of epigen...
Source: International Review of Cell and Molecular Biology - February 15, 2024 Category: Cytology Authors: Xintong Zhang Edward Barnett Jim Smith Emma Wilkinson Rathan M Subramaniam Amir Zarrabi Euan J Rodger Aniruddha Chatterjee Source Type: research

Epigenetic control of cell signalling in cancer stem cells
Int Rev Cell Mol Biol. 2024;383:67-88. doi: 10.1016/bs.ircmb.2023.07.009. Epub 2023 Aug 17.ABSTRACTThe self-renewing cancer stem cells (CSCs) represent one of the distinct cell populations occurring in a tumour that can differentiate into multiple lineages. This group of sparsely abundant cells play a vital role in tumour survival and resistance to different treatments during cancer. The lack of exclusive markers associated with CSCs makes diagnosis and prognosis in cancer patients extremely difficult. This calls for the identification of unique regulators and markers for CSCs. Various signalling pathways like the Wnt/β-c...
Source: International Review of Cell and Molecular Biology - February 15, 2024 Category: Cytology Authors: Gaurav Joshi Amitava Basu Source Type: research

Epigenetic inhibitors for cancer treatment
Int Rev Cell Mol Biol. 2024;383:89-144. doi: 10.1016/bs.ircmb.2023.06.003. Epub 2023 Jul 18.ABSTRACTEpigenetics is a heritable and reversible modification that occurs independent of the alteration of primary DNA sequence but remarkably affects genetic expression. Aberrant epigenetic regulators are frequently observed in cancer progression not only influencing the behavior of tumor cells but also the tumor-associated microenvironment (TME). Increasing evidence has shown their great potential as biomarkers to predict clinical outcomes and chemoresistance. Hence, targeting the deregulated epigenetic regulators would be a comp...
Source: International Review of Cell and Molecular Biology - February 15, 2024 Category: Cytology Authors: Hongchao Yuan Yuanjun Lu Yibin Feng Ning Wang Source Type: research