LncRNA ANRIL Promotes Glucose Metabolism and Proliferation of Colon Cancer in a High-Glucose Environment and is Associated with Worse Outcome in Diabetic Colon Cancer Patients
CONCLUSIONS: A high-glucose environment can increase the tumor-promoting effect of ANRIL. ANRIL can promote glucose metabolism and colon cancer proliferation by downregulating miR-186-5p with subsequent upregulation of glycolysis enzymes expression and inhibition of apoptosis.PMID:38679999 | DOI:10.31557/APJCP.2024.25.4.1371 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Hala Mosaad Sally M Shalaby Nevertety M Mahmoud Mona M Ahmed Alaa Fayed Hassan R Ashour Walaa Sarhan Source Type: research
M2 Macrophage Prominently Distributed in the Rat's Colon of DMH-Induced Inflammation Associated Colorectal Cancer
CONCLUSION: All of the rat's colon showing chronic inflammation that led to the tumorigenesis.PMID:38679997 | DOI:10.31557/APJCP.2024.25.4.1357 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Windy Arensya Omadhika Solikhah Solikhah Albertus Ari Adrianto Yekti Asih Purwestri Dewi Kartikawati Paramita Source Type: research
Implications of Pretreatment Serum Carcinoembryonic Antigen Levels and Perineural Invasion with Staging, Prognosis, and Management in Stage I-III Colon Cancer after Surgery: A Retrospective Cohort Study in the SEER Database
CONCLUSION: For postoperative patients with stage I-III colon cancer, our study indicated that the CP stage is a significant prognostic factor for CSS, which deserves more clinical attention. It's worth noting that including the CP stage in the AJCC TNM staging system of colon carcinoma is beneficial to the survival prediction and clinical treatment.PMID:38684496 | DOI:10.62713/aic.3296 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Qing Zhang Li Wang Ruirui Sun Jian Gao Tingting Liu Source Type: research
The Relationship of Microsatellite Instability with BRAF and p53 Mutations and Histopathological Parameters in Colorectal Adenocarcinoma
CONCLUSION: In colorectal adenocarcinoma, MSI and BRAF mutation are associated with parameters, indicating the host immune response and prognostic histopathological parameters, including tumor size and histological grade. The evaluation of MSI status and BRAF mutation can be particularly informative for predicting the prognosis and guiding the treatment management in poorly differentiated colorectal adenocarcinoma. Understanding the mechanisms of molecular carcinogenesis in colorectal carcinoma and organizing treatment algorithms based on molecular foundations will increase the success of the treatment.PMID:38684491 | DOI:...
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Özgecan Gündoğar Sibel Bekta ş Emine Y ıldırım Do ğan Gönüllü Source Type: research
LncRNA ANRIL Promotes Glucose Metabolism and Proliferation of Colon Cancer in a High-Glucose Environment and is Associated with Worse Outcome in Diabetic Colon Cancer Patients
CONCLUSIONS: A high-glucose environment can increase the tumor-promoting effect of ANRIL. ANRIL can promote glucose metabolism and colon cancer proliferation by downregulating miR-186-5p with subsequent upregulation of glycolysis enzymes expression and inhibition of apoptosis.PMID:38679999 | DOI:10.31557/APJCP.2024.25.4.1371 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Hala Mosaad Sally M Shalaby Nevertety M Mahmoud Mona M Ahmed Alaa Fayed Hassan R Ashour Walaa Sarhan Source Type: research
M2 Macrophage Prominently Distributed in the Rat's Colon of DMH-Induced Inflammation Associated Colorectal Cancer
CONCLUSION: All of the rat's colon showing chronic inflammation that led to the tumorigenesis.PMID:38679997 | DOI:10.31557/APJCP.2024.25.4.1357 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Windy Arensya Omadhika Solikhah Solikhah Albertus Ari Adrianto Yekti Asih Purwestri Dewi Kartikawati Paramita Source Type: research
Implications of Pretreatment Serum Carcinoembryonic Antigen Levels and Perineural Invasion with Staging, Prognosis, and Management in Stage I-III Colon Cancer after Surgery: A Retrospective Cohort Study in the SEER Database
CONCLUSION: For postoperative patients with stage I-III colon cancer, our study indicated that the CP stage is a significant prognostic factor for CSS, which deserves more clinical attention. It's worth noting that including the CP stage in the AJCC TNM staging system of colon carcinoma is beneficial to the survival prediction and clinical treatment.PMID:38684496 | DOI:10.62713/aic.3296 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Qing Zhang Li Wang Ruirui Sun Jian Gao Tingting Liu Source Type: research
The Relationship of Microsatellite Instability with BRAF and p53 Mutations and Histopathological Parameters in Colorectal Adenocarcinoma
CONCLUSION: In colorectal adenocarcinoma, MSI and BRAF mutation are associated with parameters, indicating the host immune response and prognostic histopathological parameters, including tumor size and histological grade. The evaluation of MSI status and BRAF mutation can be particularly informative for predicting the prognosis and guiding the treatment management in poorly differentiated colorectal adenocarcinoma. Understanding the mechanisms of molecular carcinogenesis in colorectal carcinoma and organizing treatment algorithms based on molecular foundations will increase the success of the treatment.PMID:38684491 | DOI:...
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Özgecan Gündoğar Sibel Bekta ş Emine Y ıldırım Do ğan Gönüllü Source Type: research
Molecules, Vol. 29, Pages 2043: Extraction and Isolation of Two Polysaccharides from Chloranthus japonicus Sieb. and Evaluation of Their Anti-Gastric Cancer Activities
g
Zhimin Zhao
Two unreported heteropolysaccharides, denoted as YCJP–1 and YCJP–2, were isolated from the herbs of Chloranthus japonicus. YCJP–1 was a heteropolysaccharide composed of glucose, galactose, arabinose, mannose, rhamnose, and a minor proportion of uronic acids, with the molecular weight mainly distributed in the 74,475–228,443 Da range. YCJP–2 was mainly composed of glucose, mannose, and galactose, with the molecular weights ranging from 848 to 5810 Da. To further evaluate the anti-gastric cancer effects of C. japonicus, the inhibitory e...
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Ju Liu Wenfeng Li Lu Jin Yingchao Wang Xinjun Xu Enyao Ma Depo Yang Zhimin Zhao Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2053: Antioxidant and Cytotoxic Properties of Berberis vulgaris (L.) Stem Bark Dry Extract
asela Elena Gîrd
Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigated B. vulgaris stem bark (Berberidis cortex) by extraction with 50% ethanol. The main secondary metabolites were quantified, resulting in a polyphenols content of 17.6780 ± 3.9320 mg Eq tannic acid/100 g extract, phenolic acids amount of 3.3886 ± 0.3481 mg Eq chlorogenic acid/100 g extract and 78.95 µg/g berberine. The dried hydro-ethanolic extract (BVE) was thoroughly analyzed using Ultra-High-Performance Liquid Chrom...
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Ionu ț Mădălin Ivan Octavian Tudorel Olaru Violeta Popovici Carmen Lidia Chi țescu Liliana Popescu Emanuela Alice Lu ță Elena Iuliana Ilie Lorelei Irina Bra șoveanu Camelia Mia Hotnog George Mihai Ni țulescu Rica Boscencu Cerasela Elena G îrd Tags: Article Source Type: research
Optimal surgical approach for mid-transverse colon cancer: a systematic review and meta-analysis
ConclusionDespite harvesting less LN, transverse colectomy has similar oncological outcomes to extended hemicolectomy for mid-transverse colon cancer. In addition to that, there was no significant difference in the incidence of complications between the two surgeries. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 29, 2024 Category: Cancer & Oncology Source Type: research
NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression
AbstractColorectal cancer (CRC) is a prevalent and aggressive malignancy with high mortality rates and significant risks to human well-being. Population-wide screening for tumor suppressor genes and oncogenes shows promise for reducing the incidence and fatality of CRC. Recent studies have suggested that NLRX1, an innate immunity suppressor, may play a role in regulating chronic inflammation and tumorigenesis. However, further investigation is needed to understand the specific role of NLRX1 in CRC. To evaluate the impact of NLRX1 on migration, invasion, and metastasis, two human colon cancer cell lines were studied in vitr...
Source: Medical Oncology - April 29, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1746: Bovine Meat and Milk Factor-like Sequences Are Frequently Detected in Renal Cell Carcinoma Tissues
ah
Axel zur Hausen
Previous studies have indicated a potential role of diet in the pathogenesis of renal cell carcinoma (RCC). Recently, circular bovine meat and milk factor (BMMF) DNAs have been identified in peritumoral tissues of human colon and breast cancers. Here, we investigated the prevalence of the DNA of these novel human pathogenic infectious agents in RCC and adjacent peritumoral renal tissues. DNA was extracted from formalin-fixed and paraffin-embedded (FFPE) RCC and peritumoral kidney tissues, including a test (n = 11) and a validation (n = 152) collection. BMMF1 and BMMF2 consensus primers were designe...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Ghalib Mobaraki Shuai Shi Kim M. Smits Kim Severens Kim Lommen Dorit Rennspiess Emil Chteinberg V éronique Winnepenninckx Iryna Samarska Faisal Klufah Axel zur Hausen Tags: Article Source Type: research
A simplified algorithm to evaluate the risk of submucosal invasive cancer in large ( ≥20 mm) nonpedunculated colonic polyps
Conclusions This decision-making algorithm simplifies
identification of LNPCPs with an increased risk of potential SMIC. When combined with surface
optical evaluation, it facilitates accurate lesion characterization and resection
choices. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Endoscopy)
Source: Endoscopy - April 29, 2024 Category: Gastroenterology Authors: O'Sullivan, Timothy Craciun, Ana Byth, Karen Gupta, Sunil Gauci, Julia Louisa Cronin, Oliver Whitfield, Anthony Abuarisha, Muhammad Williams, Stephen John Lee, Eric Yong Tat Burgess, Nicholas Graeme Bourke, Michael J. Tags: Original article Source Type: research
Difficulties and Disparities in Colorectal Cancer End-of-Life Care: A Patient's Story
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786393Patients with advanced colorectal cancer nearing the end of life require a multidisciplinary approach to address the unique challenges they face. Using a case vignette, we outline the various stages of a patient's journey with advanced rectal cancer and the common obstacles to their care as they interface with the medical system. We highlight how Black persons might be vulnerable to differences in screening, treatment, procedural interventions, end-of-life care, and health care decision-making. The article also addresses how health inequities and barriers relating to concor...
Source: Clinics in Colon and Rectal Surgery - April 29, 2024 Category: Surgery Authors: Ranson, Stacy Noreika, Danielle Rivet, Emily B. Tags: Review Article Source Type: research
