Mini-colon and brain 'organoids' shed light on cancer and other diseases
Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01199-xTiny 3D structures made from human stem cells sometimes offer insights that animal models cannot. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Sara Reardon Source Type: research
H2S-driven chemotherapy and mild photothermal therapy induced mitochondrial reprogramming to promote cuproptosis
The elevated level of hydrogen sulfide (H2S) in colon cancer hinders complete cure with a single therapy. However, excessive H2S also offers a treatment target. A multifunctional cascade bioreactor based on the H (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 24, 2024 Category: Nanotechnology Authors: Lihong Qiao, Yijing Ou, Lin Li, Shuzhen Wu, Yanxian Guo, Mu Liu, Dongsheng Yu, Qinghua Chen, Jianmin Yuan, Chuanqi Wei, Chiyi Ou, Haowen Li, Du Cheng, Zhiqiang Yu and Zhongjun Li Tags: Research Source Type: research
Mini-colon and brain ‘organoids’ shed light on cancer and other diseases
Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01199-xTiny 3D structures made from human stem cells sometimes offer insights that animal models cannot. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Sara Reardon Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Endocannabinoid remodeling in murine cachexic muscle associates with catabolic and metabolic regulation
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167179. doi: 10.1016/j.bbadis.2024.167179. Online ahead of print.ABSTRACTMuscle degeneration is a common feature in cancer cachexia that cannot be reversed. Recent advances show that the endocannabinoid system, and more particularly cannabinoid receptor 1 (CB1), regulates muscle processes, including metabolism, anabolism and regenerative capacity. However, it is unclear whether muscle endocannabinoids, their receptors and enzymes are responsive to cachexia and exercise. Therefore, this study investigated whether cachexia and exercise affected muscle endocannabinoid signaling,...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Sebastiaan Dalle Charlotte Hiroux Katrien Koppo Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Endocannabinoid remodeling in murine cachexic muscle associates with catabolic and metabolic regulation
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167179. doi: 10.1016/j.bbadis.2024.167179. Online ahead of print.ABSTRACTMuscle degeneration is a common feature in cancer cachexia that cannot be reversed. Recent advances show that the endocannabinoid system, and more particularly cannabinoid receptor 1 (CB1), regulates muscle processes, including metabolism, anabolism and regenerative capacity. However, it is unclear whether muscle endocannabinoids, their receptors and enzymes are responsive to cachexia and exercise. Therefore, this study investigated whether cachexia and exercise affected muscle endocannabinoid si...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Sebastiaan Dalle Charlotte Hiroux Katrien Koppo Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Survival trends for left and right sided colon cancer using population ‐based SEER database: A forty‐five‐year analysis from 1975 to 2019
ConclusionLSCC was associated with superior survival compared to right sided tumors. With the adoption of modern chemotherapy regimens, prognosis between LSCC and RSCC became more divergent in favor of LSCC. Colon cancer clinical trials should strongly consider tumor sidedness as an enrollment factor. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Mark B. Ulanja,
Kwabena Oppong Asafo ‐Agyei,
Vijay Neelam,
Bryce D. Beutler,
Daniel Antwi‐Amoabeng,
Samuel B. Governor,
Ganiyu A. Rahman,
Francis T. Djankpa,
Reginald N. Ulanja,
Grace B. Nteim,
Tarig Mabrouk,
Millicent Amankwah,
Olatunji B Tags: RESEARCH ARTICLE Source Type: research
N-methyl-D-aspartate receptors and thymoquinone induce apoptosis and alteration in mitochondria in colorectal cancer cells
This study aimed to determine the roles of N-Methyl-D-Aspartate agonists and Thymoquinone on mitochondria and apoptosis. HT-29 cells were treated with different TQ and MK-801 concentrations. We analyzed cell viability, apoptosis, and alteration of mitochondria. Cell viability significantly decreased depending on doses of TQ and MK-801. Apoptosis and mitochondrial dysfunctions induced by low and high doses of TQ and MK-801. Our study emphasizes the need for further safety evaluation of MK-801 due to the potential toxicity risk of TQ and MK-801. Optimal and toxic doses of TQ and MK-801 were determined for the treatment of co...
Source: Medical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Isolated Inguinal Lymph Node Metastasis from Colon Cancer: A Case Report
We reported a rare case of isolated metachronous inguinal lymph node metastasis from colon cancer with a round ligament route of spread as the hypothesized mechanism. Surgical resection with inguinal LN dissection is the preferred treatment option for isolated inguinal lymph node metastasis from colon cancer followed by adjuvant chemotherapy, yet long term follow-up data is needed to support this strategy. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
C6orf15 promotes liver metastasis via WNT/ β-catenin signalling in colorectal cancer
Colon cancer ranks third among global tumours and second in cancer-related mortality, prompting an urgent need to explore new therapeutic targets. C6orf15 is a novel gene that has been reported only in Sjogren... (Source: Cancer Cell International)
Source: Cancer Cell International - April 23, 2024 Category: Cancer & Oncology Authors: Jiankang Yu, Jian Sun, Jingtong Tang, Jiayu Xu, Guanru Qian and Jianping Zhou Tags: Research Source Type: research
Promising anticancer activity of cromolyn in colon cancer: in vitro and in vivo analysis
CONCLUSION: Our study showed that cromolyn is a selective and strong drug in inhibiting the proliferation of colon cancer cells. Based on our results, the efficacy of C in vitro analysis (MTT assays and apoptosis), as well as animal studies is competitive with the FDA-approved drug doxorubicin. C is very promising as a low-complication and good-efficacy drug for cancer drug repositioning. This requires clinical research study designs to comprehensively evaluate its anti-cancer effects.PMID:38647571 | DOI:10.1007/s00432-024-05741-2 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Amin Aliabadi Mohammad Reza Haghshenas Razie Kiani Mohammad Reza Panjehshahin Nasrollah Erfani Source Type: research
