Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors: A decade-apart study of two nationwide cohorts
CONCLUSION: Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events (stroke 28%, PE 47%, arrhythmia 41%, and cardiac arrest 63%). It is vital to regularly screen colon cancer survivors with concomitant CVD risk factors to curtail long-term cardiovascular complications.PMID:38689632 | PMC:PMC11056864 | DOI:10.5306/wjco.v15.i4.548 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Rupak Desai Avilash Mondal Vivek Patel Sandeep Singh Shaylika Chauhan Akhil Jain Source Type: research
Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Keigo Nishida Naoya Nakagawa Source Type: research
Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Keigo Nishida Naoya Nakagawa Source Type: research
Retraction Note: Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
(Source: Apoptosis)
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Mechanism of bufalin inhibition of colon cancer liver metastasis by regulating M2-type polarization of Kupffer cells induced by highly metastatic colon cancer cells
AbstractPatients with metastatic colorectal cancer often have poor outcomes, primarily due to hepatic metastasis. Colorectal cancer (CRC) cells have the ability to secrete cytokines and other molecules that can remodel the tumor microenvironment, facilitating the spread of cancer to the liver. Kupffer cells (KCs), which are macrophages in the liver, can be polarized to M2 type, thereby promoting the expression of adhesion molecules that aid in tumor metastasis. Our research has shown that huachanshu (with bufalin as the main active monomer) can effectively inhibit CRC metastasis. However, the underlying mechanism still nee...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies
Cell Death & Disease, Published online: 01 May 2024; doi:10.1038/s41419-024-06690-xImpact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies (Source: Cell death and disease)
Source: Cell death and disease - May 1, 2024 Category: Internal Medicine Authors: Maria Virginia Giolito Serguei Bodoirat Theo La Rosa Mathieu Reslinger Gabriela D. A. Guardia Jana Mourtada Leo Claret Alain Joung Pedro A. F. Galante Luiz O. F. Penalva Michelina Plateroti Source Type: research
Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)
CONCLUSION: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.PMID:38685844 | DOI:10.34172/aim.2024.27 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Bahar Saberzadeh-Ardestani Amir Ali Khosravi Fariborz Mansour-Ghanaei Homayoon Vahedi Nadieh Baniasadi Mohammadreza Seyyedmajidi Baran Parhizkar Ahmad Hormati Sayed Jalalledin Naghshbandi Somaieh Matin Amir Abbas Hassan Zadeh Tarang Taghvaei Mohsen Bahram Source Type: research
Determinants of early-onset colorectal cancer: a multicenter case-control study in Iran
CONCLUSION: Early-onset CRC was related to the intake of vegetables, vitamin D and red meat in Iran. Early-onset rectum cancer was associated with regular opium use. Family history was associated with early CRC and early rectum cancer, particularly below the age of 35.PMID:38687254 | DOI:10.1097/CEJ.0000000000000888 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Giulia Collatuzzo Monireh Sadat Seyyedsalehi Hamideh Rashidian Maryam Hadji Roya Safari-Faramani Abbas Rezaianzadeh Reza Malekzadeh Kazem Zendehdel Paolo Boffetta Source Type: research
Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)
CONCLUSION: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.PMID:38685844 | DOI:10.34172/aim.2024.27 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Bahar Saberzadeh-Ardestani Amir Ali Khosravi Fariborz Mansour-Ghanaei Homayoon Vahedi Nadieh Baniasadi Mohammadreza Seyyedmajidi Baran Parhizkar Ahmad Hormati Sayed Jalalledin Naghshbandi Somaieh Matin Amir Abbas Hassan Zadeh Tarang Taghvaei Mohsen Bahram Source Type: research
Synthesis and cytotoxicity of novel 6,8,9-Trisubstituted purine analogs against liver cancer cells
Bioorg Med Chem Lett. 2024 Apr 28:129775. doi: 10.1016/j.bmcl.2024.129775. Online ahead of print.ABSTRACTA series of novel 6-(substituted phenyl piperazine)-8-(4-substituted phenyl)-9-cyclopentyl purines, 10-51, were synthesized by a four-step synthesis, achieving an overall yield of about 43 %. The reaction conditions were effectively optimized, and the final products were obtained with high purity and yield in all synthesis steps. The synthesized nucleobases were evaluated for their in vitro cytotoxic activities on selected human cancer cell lines (HUH7 (liver), HCT116 (colon), and MCF7 (breast)) using the Sulforhodamine...
Source: Bioorganic and Medicinal Chemistry Letters - April 30, 2024 Category: Chemistry Authors: M Fatih Polat Irem Durmaz Şahin P ınar Kul Rengul Cetin Atalay Meral Tuncbilek Source Type: research
Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)
CONCLUSION: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.PMID:38685844 | DOI:10.34172/aim.2024.27 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Bahar Saberzadeh-Ardestani Amir Ali Khosravi Fariborz Mansour-Ghanaei Homayoon Vahedi Nadieh Baniasadi Mohammadreza Seyyedmajidi Baran Parhizkar Ahmad Hormati Sayed Jalalledin Naghshbandi Somaieh Matin Amir Abbas Hassan Zadeh Tarang Taghvaei Mohsen Bahram Source Type: research
Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells
Bioorg Med Chem Lett. 2024 Apr 28;106:129775. doi: 10.1016/j.bmcl.2024.129775. Online ahead of print.ABSTRACTA series of novel 6-(substituted phenyl piperazine)-8-(4-substituted phenyl)-9-cyclopentyl purines, 10-51, were synthesized by a four-step synthesis, achieving an overall yield of about 43 %. The reaction conditions were effectively optimized, and the final products were obtained with high purity and yield in all synthesis steps. The synthesized nucleobases were evaluated for their in vitro cytotoxic activities on selected human cancer cell lines (HUH7 (liver), HCT116 (colon), and MCF7 (breast)) using the Sulforhoda...
Source: Bioorganic and Medicinal Chemistry Letters - April 30, 2024 Category: Chemistry Authors: M Fatih Polat Irem Durmaz Şahin P ınar Kul Rengul Cetin Atalay Meral Tuncbilek Source Type: research
Genes, Vol. 15, Pages 577: Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes
ynski
P53 overexpression plays a critical role in cancer pathogenesis by disrupting the intricate regulation of cellular proliferation. Despite its firmly established function as a tumor suppressor, elevated p53 levels can paradoxically contribute to tumorigenesis, influenced by factors such as exposure to carcinogens, genetic mutations, and viral infections. This phenomenon is observed across a spectrum of cancer types, including bladder (BLCA), ovarian (OV), cervical (CESC), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), diffuse large B-cell lymphoma (DLBC), esophageal carcinoma (ESCA), head and neck squamou...
Source: Genes - April 30, 2024 Category: Genetics & Stem Cells Authors: Ruby Khan Bakht Pari Krzysztof Puszynski Tags: Article Source Type: research
