(Sialyl)Lewis antigen expression on glycosphingolipids, N- and O-glycans in colorectal cancer cell lines is linked to a colon-like differentiation program
In conclusion, our study provides insights into the possible regulation of glycans in CRC and can serve as a guide for the development of diagnostic and therapeutic biomarkers.PMID:38670309 | DOI:10.1016/j.mcpro.2024.100776 (Source: Molecular and Cellular Proteomics : MCP)
Source: Molecular and Cellular Proteomics : MCP - April 26, 2024 Category: Molecular Biology Authors: Di Wang Katarina Maduni ć Oleg A Mayboroda Guinevere S M Lageveen-Kammeijer Manfred Wuhrer Source Type: research
Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research
Ginsenoside Rg1 Induces Autophagy in Colorectal Cancer through Inhibition of the Akt/mTOR/p70S6K Pathway
This study aimed to elucidate the anti-colon cancer mechanism of ginsenoside Rg1 in vitro and in vivo. Cell viability rate was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tetrazolium assay. The inhibitory effect of ginsenoside Rg1 against CT26 cell proliferation gradually increased with increasing concentration. The in vivo experiments also demonstrated an antitumor effect. The monodansylcadaverine (MDC), transmission electron microscopy (TEM), and expression of autophagy marker proteins confirmed that ginsenoside Rg1 induced autophagy in vitro. Ginsenoside Rg1 induced autophagy de...
Source: Journal of Microbiology and Biotechnology - April 26, 2024 Category: Biotechnology Authors: Ruiqi Liu Bin Zhang Shuting Zou Li Cui Lin Lin Lingchang Li Source Type: research
Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)
CONCLUSIONS: Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment.PMID:38665026 | DOI:10.24976/Discov.Med.202436183.73 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Aixi Sun Jian Ge Kaixin Ding Zhiyang Gao Yun Zhang Source Type: research
The Impact of the Pandemic on the Quality of Colorectal and Anal Cancer Care, and 2-Year Clinical Outcomes
Curr Oncol. 2024 Apr 19;31(4):2328-2340. doi: 10.3390/curroncol31040173.ABSTRACTWe undertook a retrospective study to compare the quality of care delivered to a cohort of newly diagnosed adults with colon, rectal or anal cancer during the early phase of COVID-19 (02/20-12/20) relative to the same period in the year prior (the comparator cohort), and examine the impact of the pandemic on 2-year disease progression and all-cause mortality. We observed poorer performance on a number of quality measures, such as approximately three times as many patients in the COVID-19 cohort experienced 30-day post-surgical readmission (10.5...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Melanie Powis Rinku Sutradhar Simron Singh Shabbir Alibhai Saidah Hack Abed Baiad Kevin Chen Huaqi Li Zuhal Mohmand Monika K Krzyzanowska Source Type: research
The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review
Curr Oncol. 2024 Apr 3;31(4):1994-2023. doi: 10.3390/curroncol31040149.ABSTRACTMelatonin is a multifunctional hormone regulator that maintains homeostasis through circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal disorders and increase the risk of cancer. Preliminary clinical studies have shown that exogenous melatonin alleviates the harmful effects of anticancer therapy and improves quality of life, but the results are still inconclusive due to the heterogeneity of the studies. A personalized approach to testing clinical parameters and response to integrative treatment with nontoxic an...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Eugeniy Smorodin Valentin Chuzmarov Toomas Veidebaum Source Type: research
Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1
Oncol Rep. 2024 Jun;51(6):82. doi: 10.3892/or.2024.8741. Epub 2024 Apr 26.ABSTRACTColorectal cancer (CRC) is one of the most common malignancies worldwide. The 5‑year survival rate of patients diagnosed with the early stages of the disease is markedly higher than that of patients in the advanced stages. Therefore, identifying novel biomarkers and drug targets for CRC is critical for clinical practice. Zinc finger protein 169 (ZNF169) is a crucial transcription factor, and its role in CRC remains to be explored. The present study aimed to investigate the clinical relevance, function and underlying mechanisms of ZNF169 in ...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Jie Zhang Ye Wang Shiyang Hou Xiaoqian Chi Danyang Ding Mei Xue Mengqiao Zhang Jing Wang Junfang Shuai Haiying Sun Qiang Gao Chunbo Kang Source Type: research
Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research
Ginsenoside Rg1 Induces Autophagy in Colorectal Cancer through Inhibition of the Akt/mTOR/p70S6K Pathway
This study aimed to elucidate the anti-colon cancer mechanism of ginsenoside Rg1 in vitro and in vivo. Cell viability rate was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tetrazolium assay. The inhibitory effect of ginsenoside Rg1 against CT26 cell proliferation gradually increased with increasing concentration. The in vivo experiments also demonstrated an antitumor effect. The monodansylcadaverine (MDC), transmission electron microscopy (TEM), and expression of autophagy marker proteins confirmed that ginsenoside Rg1 induced autophagy in vitro. Ginsenoside Rg1 induced autophagy de...
Source: Journal of Microbiology and Biotechnology - April 26, 2024 Category: Biotechnology Authors: Ruiqi Liu Bin Zhang Shuting Zou Li Cui Lin Lin Lingchang Li Source Type: research
Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)
CONCLUSIONS: Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment.PMID:38665026 | DOI:10.24976/Discov.Med.202436183.73 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Aixi Sun Jian Ge Kaixin Ding Zhiyang Gao Yun Zhang Source Type: research
The Impact of the Pandemic on the Quality of Colorectal and Anal Cancer Care, and 2-Year Clinical Outcomes
Curr Oncol. 2024 Apr 19;31(4):2328-2340. doi: 10.3390/curroncol31040173.ABSTRACTWe undertook a retrospective study to compare the quality of care delivered to a cohort of newly diagnosed adults with colon, rectal or anal cancer during the early phase of COVID-19 (02/20-12/20) relative to the same period in the year prior (the comparator cohort), and examine the impact of the pandemic on 2-year disease progression and all-cause mortality. We observed poorer performance on a number of quality measures, such as approximately three times as many patients in the COVID-19 cohort experienced 30-day post-surgical readmission (10.5...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Melanie Powis Rinku Sutradhar Simron Singh Shabbir Alibhai Saidah Hack Abed Baiad Kevin Chen Huaqi Li Zuhal Mohmand Monika K Krzyzanowska Source Type: research
The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review
Curr Oncol. 2024 Apr 3;31(4):1994-2023. doi: 10.3390/curroncol31040149.ABSTRACTMelatonin is a multifunctional hormone regulator that maintains homeostasis through circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal disorders and increase the risk of cancer. Preliminary clinical studies have shown that exogenous melatonin alleviates the harmful effects of anticancer therapy and improves quality of life, but the results are still inconclusive due to the heterogeneity of the studies. A personalized approach to testing clinical parameters and response to integrative treatment with nontoxic an...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Eugeniy Smorodin Valentin Chuzmarov Toomas Veidebaum Source Type: research
Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1
Oncol Rep. 2024 Jun;51(6):82. doi: 10.3892/or.2024.8741. Epub 2024 Apr 26.ABSTRACTColorectal cancer (CRC) is one of the most common malignancies worldwide. The 5‑year survival rate of patients diagnosed with the early stages of the disease is markedly higher than that of patients in the advanced stages. Therefore, identifying novel biomarkers and drug targets for CRC is critical for clinical practice. Zinc finger protein 169 (ZNF169) is a crucial transcription factor, and its role in CRC remains to be explored. The present study aimed to investigate the clinical relevance, function and underlying mechanisms of ZNF169 in ...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Jie Zhang Ye Wang Shiyang Hou Xiaoqian Chi Danyang Ding Mei Xue Mengqiao Zhang Jing Wang Junfang Shuai Haiying Sun Qiang Gao Chunbo Kang Source Type: research
Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research
Ginsenoside Rg1 Induces Autophagy in Colorectal Cancer through Inhibition of the Akt/mTOR/p70S6K Pathway
This study aimed to elucidate the anti-colon cancer mechanism of ginsenoside Rg1 in vitro and in vivo. Cell viability rate was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tetrazolium assay. The inhibitory effect of ginsenoside Rg1 against CT26 cell proliferation gradually increased with increasing concentration. The in vivo experiments also demonstrated an antitumor effect. The monodansylcadaverine (MDC), transmission electron microscopy (TEM), and expression of autophagy marker proteins confirmed that ginsenoside Rg1 induced autophagy in vitro. Ginsenoside Rg1 induced autophagy de...
Source: Journal of Microbiology and Biotechnology - April 26, 2024 Category: Biotechnology Authors: Ruiqi Liu Bin Zhang Shuting Zou Li Cui Lin Lin Lingchang Li Source Type: research
