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Research Progress on Strategies for Improving the Enzyme Properties of Bacteriophage Endolysins
J Microbiol Biotechnol. 2024 Feb 28;34(6):1-8. doi: 10.4014/jmb.2312.12050. Online ahead of print.ABSTRACTBacterial resistance to commonly used antibiotics is one of the major challenges to be solved today. Bacteriophage endolysins (Lysins) have become a hot research topic as a new class of antibacterial agents. They have promising applications in bacterial infection prevention and control in multiple fields, such as livestock and poultry farming, food safety, clinical medicine and pathogen detection. However, many phage endolysins display low bactericidal activities, short half-life and narrow lytic spectrums. Therefore, ...
Source: Journal of Microbiology and Biotechnology - May 1, 2024 Category: Biotechnology Authors: Yulu Wang Xue Wang Xin Liu Bokun Lin Source Type: research

Novel Qnr Families as Conserved and Intrinsic Quinolone Resistance Determinants in < em > Aeromonas < /em > spp
In this study, five environmental strains of Aeromonas spp. exhibiting multidrug resistance (MDR) were selected for whole-genome sequencing to ascertain their taxonomic assignment at the species-level and to delineate their ARG repertoires. Analyses of their genomes revealed the presence of one protein almost identical to AhQnr (A. hydrophila Qnr protein) and four novel proteins similar to AhQnr. To scrutinize the classification and taxonomic distribution of these proteins, all Aeromonas genomes deposited in the NCBI RefSeq genome database (1,222 genomes) were investigated. This revealed that these Aeromonas Qnr (AQnr) pro...
Source: Journal of Microbiology and Biotechnology - May 1, 2024 Category: Biotechnology Authors: Sang-Gyu Kim Bo-Eun Kim Jung Hun Lee Dae-Wi Kim Source Type: research

Evaluating the Nutritional Composition of Unripe Citrus and Its Effect on Inhibiting Adipogenesis and Adipocyte Differentiation
In this study, we assessed the nutritional components of unripe citrus peel and pressed juices, as well as their anti-obesity potential through the modulation of adipocyte differentiation and the expression of adipogenesisrelated genes, specifically PPARγ and C/EBPα, in 3T3-L1 preadipocytes. Our analysis revealed that unripe citrus peel exhibited elevated levels of fiber and protein compared to pressed juice, with markedly low levels of free sugar, particularly sucrose. The content of hesperidin, a representative flavonoid in citrus fruits, was 3,157.6 mg/kg in unripe citrus peel and 455.5 mg/kg in pressed juice, indicat...
Source: Journal of Microbiology and Biotechnology - May 1, 2024 Category: Biotechnology Authors: Sunghee Kim Eunbi Lee Juhye Park Ju-Ock Nam Soo Rin Kim Source Type: research

Morphological Engineering of Filamentous Fungi: Research Progress and Perspectives
J Microbiol Biotechnol. 2024 Mar 26;34(6):1-9. doi: 10.4014/jmb.2402.02007. Online ahead of print.ABSTRACTFilamentous fungi are important cell factories for the production of high-value enzymes and chemicals for the food, chemical, and pharmaceutical industries. Under submerged fermentation, filamentous fungi exhibit diverse fungal morphologies that are influenced by environmental factors, which in turn affect the rheological properties and mass transfer of the fermentation system, and ultimately the synthesis of products. In this review, we first summarize the mechanisms of mycelial morphogenesis and then provide an overv...
Source: Journal of Microbiology and Biotechnology - May 1, 2024 Category: Biotechnology Authors: Zhengwu Lu Zhiqun Chen Yunguo Liu Xuexue Hua Cuijuan Gao Jingjing Liu Source Type: research

Ginsenoside Rg1 Induces Autophagy in Colorectal Cancer through Inhibition of the Akt/mTOR/p70S6K Pathway
This study aimed to elucidate the anti-colon cancer mechanism of ginsenoside Rg1 in vitro and in vivo. Cell viability rate was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tetrazolium assay. The inhibitory effect of ginsenoside Rg1 against CT26 cell proliferation gradually increased with increasing concentration. The in vivo experiments also demonstrated an antitumor effect. The monodansylcadaverine (MDC), transmission electron microscopy (TEM), and expression of autophagy marker proteins confirmed that ginsenoside Rg1 induced autophagy in vitro. Ginsenoside Rg1 induced autophagy de...
Source: Journal of Microbiology and Biotechnology - April 26, 2024 Category: Biotechnology Authors: Ruiqi Liu Bin Zhang Shuting Zou Li Cui Lin Lin Lingchang Li Source Type: research

Efficacy Assessment of the Co-Administration of Vancomycin and Metronidazole in < em > Clostridioides difficile < /em > -Infected Mice Based on Changes in Intestinal Ecology
In this study, a CDI mouse model was constructed to evaluate the therapeutic effects of VAN and MTR alone or in combination. For a perspective on the intestinal ecology, 16S rRNA amplicon sequencing and non-targeted metabolomics techniques were used to investigate changes in the fecal microbiota and metabolome of mice under the co-administration treatment. As a result, the survival rate of mice under co-administration was not dramatically different compared to that of single antibiotics, and the former caused intestinal tissue hyperplasia and edema. Co-administration also significantly enhanced the activity of amino acid m...
Source: Journal of Microbiology and Biotechnology - April 26, 2024 Category: Biotechnology Authors: Saiwei Zhong Jingpeng Yang He Huang Source Type: research

Corrigendum to: Low Molecular Weight Collagen Peptide (LMWCP) Promotes Hair Growth by Activating the Wnt/GSK-3 β/β-Catenin Signaling Pathway
J Microbiol Biotechnol. 2024 Apr 28;34(4):985-986. doi: 10.4014/jmb.2024.3404.985.NO ABSTRACTPMID:38668686 | DOI:10.4014/jmb.2024.3404.985 (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - April 26, 2024 Category: Biotechnology Authors: Yujin Kim Jung Ok Lee Jung Min Lee Mun-Hoe Lee Hyeong-Min Kim Hee-Chul Chung Do-Un Kim Jin-Hee Lee Beom Joon Kim Source Type: research