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Fenchone Ameliorates ConstipationPredominant Irritable Bowel Syndrome via Modulation of SCF/c-Kit Pathway and Gut Microbiota
In this study we sought to elucidate the therapeutic effects of fenchone on constipation-predominant irritable bowel syndrome (IBS-C) and the underlying mechanisms. An IBS-C model was established in rats by administration of ice water by gavage for 14 days. Fenchone increased the reduced body weight, number of fecal pellets, fecal moisture, and intestinal transit rate, and decreased the enhanced visceral hypersensitivity in the rat model of IBS-C. In addition, fenchone increased the serum content of excitatory neurotransmitters and decreased the serum content of inhibitory neurotransmitters in the IBS-C rat model. Meanwhil...
Source: Journal of Microbiology and Biotechnology - December 11, 2023 Category: Biotechnology Authors: Li Cui Bin Zhang Shuting Zou Jing Liu Pingrong Wang Hui Li Zhenhai Zhang Source Type: research

Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription
J Microbiol Biotechnol. 2023 Nov 17;34(2):1-10. doi: 10.4014/jmb.2308.08026. Online ahead of print.ABSTRACTAs a pivotal defensive line against multitudinous malignant tumors, natural killer (NK) cells exist in the tumor microenvironment (TME). RAD18 E3 Ubiquitin Protein Ligase (RAD18) has been reported to foster the malignant progression of multiple cancers, but its effect on NK function has not been mined. Here, the study was designed to mine the mechanism by which RAD18 regulates the killing effect of NK cells on colorectal cancer (CRC) cells. Expression of E2F Transcription Factor 7 (E2F7) and RAD18 in CRC tissues, thei...
Source: Journal of Microbiology and Biotechnology - December 11, 2023 Category: Biotechnology Authors: Bingdong Jiang Binghua Yan Hengjin Yang He Geng Peng Li Source Type: research

Preparation and Improvement of Physicochemical and Functional Properties of Dietary Fiber from Corn Cob Fermented by Aspergillus niger 
J Microbiol Biotechnol. 2023 Oct 16;34(2):1-10. doi: 10.4014/jmb.2308.08010. Online ahead of print.ABSTRACTCorn cobs were fermented with Aspergillus niger to produce soluble dietary fiber (SDF) of high quality and excellent food safety. In this work, the fermentation process was optimized by singlefactor test and response surface methodology (RSM). The optimal fermentation conditions were determined to be a material-liquid ratio of 1:30, an inoculum concentration of 11%, a temperature of 32oC, a time of 6 days, and a shaking speed of 200 r/min. Under these conditions, the SDF yield of corn cob increased from 2.34% to 11.92...
Source: Journal of Microbiology and Biotechnology - December 11, 2023 Category: Biotechnology Authors: Yadi Zhou Qijie Sun Chao Teng Mingchun Zhou Guangsen Fan Penghui Qu Source Type: research

Detection of Listeria Species by Conventional Culture-Dependent and Alternative Rapid Detection Methods in Retail Ready-to-Eat Foods in Turkey
J Microbiol Biotechnol. 2023 Nov 16;34(2):1-9. doi: 10.4014/jmb.2308.08043. Online ahead of print.ABSTRACTFoodborne pathogens, like Listeria monocytogenes, continue to inflict substantial financial losses on the food industry. Various methods for detecting Listeria in food have been developed and numerous studies have been conducted to compare the different methods. But, in recent years, new Listeria species have been identified, and currently the genus comprises 26 species. Therefore, it would be a more accurate approach to re-evaluate existing detection methods by considering new species. The present investigation involv...
Source: Journal of Microbiology and Biotechnology - December 11, 2023 Category: Biotechnology Authors: Emine Dincer Source Type: research

Biocontrol of Peach Gummosis by Bacillus velezensis KTA01 and Its Antifungal Mechanism
In this study, we isolated microbes from the soil surrounding peach trees exhibiting antifungal activity against B. dothidea. Subsequently, we identified several bacterial strains as potential candidates for a biocontrol agent. Among them, Bacillus velezensis KTA01 displayed the most robust antifungal activity and was therefore selected for further analysis. To investigate the antifungal mechanism of B. velezensis KTA01, we performed tests to assess cell wall degradation and siderophore production. Additionally, we conducted reverse transcriptionquantitative polymerase chain reaction (RT-qPCR) analysis based on whole-genom...
Source: Journal of Microbiology and Biotechnology - December 11, 2023 Category: Biotechnology Authors: Tae-An Kang GyuDae Lee Kihwan Kim Dongyup Hahn Jae-Ho Shin Won-Chan Kim Source Type: research