Effect of platinum ‑based chemotherapy on the expression of natural killer group 2 member D ligands, programmed cell death‑1 ligand 1 and HLA class I in non‑small cell lung cancer.
Effect of platinum‑based chemotherapy on the expression of natural killer group 2 member D ligands, programmed cell death‑1 ligand 1 and HLA class I in non‑small cell lung cancer. Oncol Rep. 2019 Jun 03;: Authors: Okita R, Maeda A, Shimizu K, Nojima Y, Saisho S, Nakata M Abstract Platinum‑based chemotherapy improves the clinical outcome of patients with non‑small cell lung cancer (NSCLC), although tumors often become refractory after treatment. Immunohistochemical staining was performed to investigate the expression levels of natural killer group 2 member D (NKG2D) ligands...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High relative levels of satellite alpha transcripts predict increased risk of bilateral breast cancer and multiple primary cancer in patients with breast cancer and lacking BRCA ‑related clinical features.
In this study, we elucidated the significance of SAT in the development of multiple tumors in patients with breast cancer. Relative expression of SAT (rSAT) was calculated in normal and tumor tissues from 167 patients. In total, 27 patients developed bilateral breast cancer (BBC) and 27 patients showed multiple primary cancer (MPC), with patients with BBC and MPC showing higher rSAT levels in tumor tissues than those in patients with single breast cancer (SBC) (P=0.0312 and P=0.0420, respectively). Additionally, higher rSAT levels in tumor tissues from patients with BBC were a significant factor according to univariate ana...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of gossypol on apoptosis ‑related gene expression in racially distinct triple‑negative breast cancer cells.
In conclusion, the data obtained in this study provide a molecular understanding of the GOSS‑induced apoptosis effect and suggest the importance of this polyphenol compound targeted towards TNBC treatment, particularly in African‑American women. PMID: 31173249 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of microRNAs associated with the aggressiveness of prolactin pituitary tumors using bioinformatic analysis.
Authors: Wang Z, Gao L, Guo X, Feng C, Deng K, Lian W, Xing B Abstract Aggressive prolactin pituitary tumors, which exhibit aggressive behaviors and resistance to conventional treatments, are a huge challenge for neurosurgeons. Many studies have investigated the roles of microRNAs (miRNAs) in pituitary tumorigenesis, invasion and metastasis, but few have explored aggressiveness‑associated miRNAs in aggressive pituitary tumors. Differentially expressed miRNAs (DEMs) between aggressive and nonaggressive prolactin pituitary tumors were screened using the GSE46294 miRNA expression profile downloaded from the GEO data...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CHD1L is associated with poor survival and promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma.
Authors: Li S, Chai Y, Ding Y, Yuan T, Wu C, Huang C Abstract Chromodomain helicase/ATPase DNA‑binding protein 1‑like gene (CHD1L) is a new oncogene which has been confirmed to be crucial to the progression of many solid tumors. In the present study, the expression of CHD1L was found to be upregulated in intrahepatic cholangiocarcinoma (ICC), which was significantly associated with histological differentiation (P=0.011), vascular invasion (P=0.002), lymph node metastasis (P=0.008) and TNM stage (P=0.001). Kaplan‑Meier survival analysis revealed that ICC patients with positive CHD1L expression had shorter...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Development of high ‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma.
Development of high‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma. Oncol Rep. 2019 Jun 05;: Authors: Vaclavikova R, Klajic J, Brynychova V, Elsnerova K, Alnaes GIG, Tost J, Kristensen VN, Rob L, Kodet R, Skapa P, Mrhalova M, Soucek P Abstract Multidrug resistance to anticancer drugs, which is often associated with enhanced expression of the ATP‑binding cassette (ABC) transporter P‑glycoprotein (encoded by the ABCB1 gene) may limit the effects of cancer therapy. Epigenetic regulation of ABCB1 expression may thus have a clinical im...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of tRNA ‑derived fragments in colon cancer by comprehensive small RNA sequencing.
This study could provide valuable cues for further research into the roles of tRFs in colon cancer. PMID: 31173257 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation.
In conclusion, the miR‑29a/b1 and miR‑29b2/c genes have methylated CpG sequences at promoter and enhancer regions that may contribute to the regulation of miR‑29 expression in BL tumours. The present findings indicated interplay between MYC and miR‑29 regulation, highlighting the potential role of EBV‑miRNAs in miR‑29 regulation for BL pathogenesis. PMID: 31173259 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of 4 ‑aminobutyrate aminotransferase (ABAT) and the lncRNA co‑expression network in the development of myelodysplastic syndrome.
Role of 4‑aminobutyrate aminotransferase (ABAT) and the lncRNA co‑expression network in the development of myelodysplastic syndrome. Oncol Rep. 2019 May 29;: Authors: Chen Y, Zhao G, Li N, Luo Z, Wang X, Gu J Abstract IncRNAs play an important role in the regulation of gene expression. The present study profiled differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic syndrome (MDS) to construct a 4‑aminobutyrate aminotransferase (ABAT)‑DEL‑DEM co‑expression network in MDS development using the Agilent human BeadChips and Gene Ontology (GO) and Kyoto Encyclopedia of Genes...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of a long non ‑coding RNA‑mediated competitive endogenous RNA network in hepatocellular carcinoma.
Identification of a long non‑coding RNA‑mediated competitive endogenous RNA network in hepatocellular carcinoma. Oncol Rep. 2019 Jun 03;: Authors: He H, Chen D, Cui S, Piao H, Tang H, Wang X, Ye P, Jin S Abstract The present study was designed to identify the endogenous RNA regulatory networks involved in hepatocellular carcinoma (HCC) by bioinformatic analysis. Both miRNA interaction network‑based correlation analysis and expression‑based Spearman correlation coefficients were utilized to identify potential mRNA‑lncRNA interactions. Then, a competitive endogenous (ce)RNA network was construc...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sulfasalazine ‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor.
In conclusion SAS could trigger ferroptosis in breast cancer cells, especially in cells with low ER expression. Therefore, SAS is a potential agent for breast cancer treatment. PMID: 31173262 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Aberrantly elevated Bmi1 promotes cervical cancer tumorigenicity and tumor sphere formation via enhanced transcriptional regulation of Sox2 genes.
Authors: Xu R, Chen L, Yang WT Abstract The exact molecular mechanisms underlying cervical tumorigenesis are poorly understood. Polycomb complex protein Bmi1 (Bmi1) is involved in the malignant transformation and biological aggressiveness of several human carcinomas. Therefore, the present study assessed the expression of Bmi1 protein in human cervical cancer tissues and examined the mechanisms involved in cervical carcinogenesis. The expression of Bmi1 protein was examined by immunohistochemistry in cervical carcinoma tissues (n=71), high‑grade squamous intraepithelial lesions (n=41) and normal cervical tis...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of transforming growth factor β1 in the inhibition of gastric cancer cell proliferation by melatonin in vitro and in vivo.
Role of transforming growth factor β1 in the inhibition of gastric cancer cell proliferation by melatonin in vitro and in vivo. Oncol Rep. 2019 Jun 06;: Authors: Liu H, Zhu Y, Zhu H, Cai R, Wang KF, Song J, Wang RX, Zhou RX Abstract Transforming growth factor β (TGF‑β) is a polypeptide growth factor with various biological activities, and is widely distributed in various tissues. In mammals, TGF‑β has three isoforms: TGF‑β1, 2, and 3, of which TGF‑β1 is most abundant in the TGF‑β family. TGF‑β1 is closely related to the occurrence and development of t...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ethyl pyruvate suppresses the growth, invasion and migration and induces the apoptosis of non ‑small cell lung cancer cells via the HMGB1/RAGE axis and the NF‑κB/STAT3 pathway.
Ethyl pyruvate suppresses the growth, invasion and migration and induces the apoptosis of non‑small cell lung cancer cells via the HMGB1/RAGE axis and the NF‑κB/STAT3 pathway. Oncol Rep. 2019 May 30;: Authors: Liu Q, Huo Y, Zheng H, Zhao J, Jia L, Wang P Abstract As an inhibitor of high mobility group protein B1 (HMGB1), ethyl pyruvate (EP) has been associated with various inflammatory diseases. Recent studies have investigated the relationship between EP and cancer. The present study aimed to determine the antitumor efficacy of EP in non‑small cell lung cancer (NSCLC) cells and elucid...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PTPN1 promotes the progression of glioma by activating the MAPK/ERK and PI3K/AKT pathways and is associated with poor patient survival.
In conclusion, it was demonstrated that PTPN1 is upregulated in glioma tissue and the overexpression of PTPN1 predicted the poor prognosis of patients with glioma. PTPN1 promotes the progression of glioma by activating the MAPK/ERK and PI3K/AKT pathways. PMID: 31173266 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Bile cell ‑free DNA as a novel and powerful liquid biopsy for detecting somatic variants in biliary tract cancer.
Bile cell‑free DNA as a novel and powerful liquid biopsy for detecting somatic variants in biliary tract cancer. Oncol Rep. 2019 May 31;: Authors: Shen N, Zhang D, Yin L, Qiu Y, Liu J, Yu W, Fu X, Zhu B, Xu X, Duan A, Chen Z, Wang X, Cao X, Zhao T, Zhou Z, Yu L, Qin H, Fang Z, Li JY, Liu Y, Xiong L, Yuan B, Li F, Zhang Y Abstract Tissue sampling of biliary tract carcinomas (BTCs) for molecular characterization is challenging. The aim of this study was to investigate the possibility of identifying individual actionable mutations derived from bile cell‑free DNA (cfDNA) using targeted deep sequencing....
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification and characterization of a murine model of BCR ‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis.
Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis. Oncol Rep. 2019 Jun 03;: Authors: Yu X, Zhang H, Yuan M, Zhang P, Wang Y, Zheng M, Lv Z, Odhiambo WO, Li C, Liu C, Ma Y, Ji Y Abstract Breakpoint cluster region (BCR)‑Abelson murine leukemia (ABL)1+ acute B‑lymphoblastic leukemia (B‑ALL) is a disease associated with a dismal prognosis and a high incidence of central nervous system (CNS) metastasis. However, BCR‑ABL1+ B‑ALL with CNS infiltration has not been previously characterized, at least to the best...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DNA ‑PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy.
This study was designed to investigate the effects and potential mechanism of radiosensitization associated with DNA‑dependent protein kinase catalytic subunit (DNA‑PKcs) inhibitor in human GC cell lines in vitro. Among the six GC cell lines (SGC7901, HGC‑27, MKN45, MKN74, BGC823 and MGC803) that were exposed to increasing doses of IR (0, 2, 4, 6 and 8 Gy), the mean lethal dose and quasi‑threshold dose measurements indicated that BGC823 and MGC803 were relatively insensitive to ionizing radiation (IR). IR induced significant elevation of γ H2A histone family member X (γH2AX) in MKN45 cells compared with...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Engineered human mesenchymal stem cells for neuroblastoma therapeutics.
Authors: Nieddu V, Piredda R, Bexell D, Barton J, Anderson J, Sebire N, Kolluri K, Janes SM, Karteris E, Sala A Abstract Drug-resistant neuroblastoma remains a major challenge in paediatric oncology and novel and less toxic therapeutic approaches are urgently needed to improve survival and reduce the side effects of traditional therapeutic interventions. Mesenchymal stem cells (MSCs) are an attractive candidate for cell and gene therapy since they are recruited by and able to infiltrate tumours. This feature has been exploited by creating genetically modified MSCs that are able to combat cancer by delivering therap...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Radixin knockdown improves the accumulation and efficiency of methotrexate in tumor cells.
In conclusion, the present study provides information on radixin as a target molecule for the modulation of MRP activity in tumor cells. PMID: 31115547 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ZNF492 and GPR149 methylation patterns as prognostic markers for clear cell renal cell carcinoma: Array ‑based DNA methylation profiling.
ZNF492 and GPR149 methylation patterns as prognostic markers for clear cell renal cell carcinoma: Array‑based DNA methylation profiling. Oncol Rep. 2019 May 07;: Authors: Kim YJ, Jang W, Piao XM, Yoon HY, Byun YJ, Kim JS, Kim SM, Lee SK, Seo SP, Kang HW, Kim WT, Yun SJ, Shon HS, Ryu KH, Kim SW, Ha YS, Yoon GS, Lee SC, Kwon TG, Kim WJ Abstract The present study aimed to identify novel methylation markers of clear cell renal cell carcinoma (ccRCC) using microarray methylation analysis and evaluate their prognostic relevance in patient samples. To identify cancer‑specific methylated biomarkers, microa...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Investigation of the clinical significance and prospective molecular mechanisms of cystatin genes in patients with hepatitis B virus ‑related hepatocellular carcinoma.
Investigation of the clinical significance and prospective molecular mechanisms of cystatin genes in patients with hepatitis B virus‑related hepatocellular carcinoma. Oncol Rep. 2019 May 09;: Authors: Zhou X, Wang X, Huang K, Liao X, Yang C, Yu T, Liu J, Han C, Zhu G, Su H, Qin W, Han Q, Liu Z, Huang J, Gong Y, Ye X, Peng T Abstract The present study aimed to investigate the clinical significance and prospective molecular mechanism of cystatin (CST) genes in patients with hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC). The role of CST genes in the molecular mechanism of HCC was reve...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Differential gene methylation patterns in cancerous and non ‑cancerous cells.
Differential gene methylation patterns in cancerous and non‑cancerous cells. Oncol Rep. 2019 May 15;: Authors: Kamińska K, Białkowska A, Kowalewski J, Huang S, Lewandowska MA Abstract Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present study was to characterize the prostate cancer malignant transformation model using the CpG island met...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Annexin  A2 regulates glioma cell proliferation through the STAT3‑cyclin D1 pathway.
Annexin A2 regulates glioma cell proliferation through the STAT3‑cyclin D1 pathway. Oncol Rep. 2019 May 09;: Authors: Chen L, Lin L, Xian N, Zheng Z Abstract Annexin A2 (ANXA2) acts as a calcium‑dependent phospholipid‑binding protein that is widely expressed in vertebrate cells and has abnormally high expression in various tumor cells. However, the detailed molecular mechanism underlying the effects of ANXA2 on glioma cells remains unclear. The present study aimed to investigate the role and underlying molecular mechanisms of ANXA2 in glioma cell proliferation. The results revealed that...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Small RNA sequencing revealed aberrant piRNA expression profiles in colorectal cancer.
Authors: Yin J, Qi W, Ji CG, Zhang DX, Xie XL, Ding Q, Jiang XY, Han J, Jiang HQ Abstract Piwi‑interacting RNAs (piRNAs), a novel class of non‑coding RNAs, are enriched in germ cells and implicated in spermatogenesis. Emerging evidence demonstrated deregulated expression of piRNAs in numerous tumor types. However, changes in piRNA expression profiles in colorectal cancer (CRC) have not yet been investigated. In the present study, small RNA sequencing was used to evaluate the differences in piRNA expression profiles between CRC and adjacent non‑tumor tissues, as well as to screen for differentially expressed p...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Intratumoral injection of dendritic cells overexpressing interleukin ‑12 inhibits melanoma growth.
Intratumoral injection of dendritic cells overexpressing interleukin‑12 inhibits melanoma growth. Oncol Rep. 2019 May 21;: Authors: Yao W, Li Y, Zeng L, Zhang X, Zhou Z, Zheng M, Wan H Abstract The present study aimed to investigate the antitumor effects of an intratumoral injection of dendritic cells (DCs) overexpressing interleukin-12 (IL‑12) on melanoma. DCs, isolated from mouse spleen, were gene‑modified using an IL‑12 overexpression vector. Melanoma B6 cells were injected into C57BL/6 mice to generate tumors. Thereafter, DCs overexpressing IL‑12 were injected into the tumors, and tumor v...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MEIS2 promotes cell migration and invasion in colorectal cancer.
Authors: Wan Z, Chai R, Yuan H, Chen B, Dong Q, Zheng B, Mou X, Pan W, Tu Y, Yang Q, Tu S, Hu X Abstract Colorectal cancer (CRC) is one of the most common types of malignancy worldwide. Distant metastasis is a key cause of CRC‑associated mortality. MEIS2 has been identified to be dysregulated in several types of human cancer. However, the mechanisms underlying the regulatory role of MEIS2 in CRC metastasis remain largely unknown. For the first time, the present study demonstrated that MEIS2 serves a role as a promoter of metastasis in CRC. In vivo and in vitro experiments revealed that knockdown of MEIS2 signific...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of miR ‑181a on the biological function of multiple myeloma.
Effects of miR‑181a on the biological function of multiple myeloma. Oncol Rep. 2019 May 15;: Authors: Liu N, Yang J, Yuan R, Peng J, Liu L, Guo X Abstract The present study aimed to investigate the role of miR‑181a in multiple myeloma (MM) cell lines. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect the expression of microRNA (miR)‑181a. The MM cell line RPMI 8226 stably transduced with miR‑181a mimics or inhibitor was established via lentiviral vectors. A Cell Counting Kit‑8 proliferation assay, flow cytometry and a Transwell assay were conducted ...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑497 suppresses malignant phenotype in non‑small cell lung cancer via targeting KDR.
miR‑497 suppresses malignant phenotype in non‑small cell lung cancer via targeting KDR. Oncol Rep. 2019 May 16;: Authors: Xia Y, Hu C, Lian L, Hui K, Wang L, Qiao Y, Liu L, Liang L, Jiang X Abstract The aim of the present study was to evaluate the expression of microRNA‑497 (miR‑497) in non‑small cell lung cancer (NSCLC) tissues and cell lines, and to investigate possible mechanisms associated with its regulatory role on cell behaviors. The expression level of miR‑497 was evaluated in 15 cases of NSCLC tissues and 8 adjacent normal tissues, and in 8 NSCLC cell lines, including H1975, A549, ...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HOXC10 overexpression promotes cell proliferation and migration in gastric cancer.
Authors: Kim J, Bae DH, Kim JH, Song KS, Kim YS, Kim SY Abstract Homeodomain‑containing gene 10 (HOXC10) is a member of the homeobox transcription factors that plays an important role in the development of multicellular organisms. HOXC10 is overexpressed in a variety of human cancers, and recent studies have revealed that HOXC10 is upregulated in gastric cancer as well. However, its mechanism of action is not fully understood, thus, the role of HOXC10 was investigated in the present study in human gastric cancer. First, HOXC10 expression was revealed to be significantly increased in gastric cancer tissues compare...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Conditionally replicative adenovirus carrying shRNA targeting EZH2 inhibits prostate cancer growth and invasion.
Authors: Xu SG, Yu JJ, Shi Q, Niu Q, Guo Z, Guo BY, Zhou GC, Gu X, Wu YX Abstract The present study aimed to construct conditionally replicative adenovirus (CRAds) carrying small hairpin (sh)RNA targeting enhancer of zeste homolog 2 (EZH2), in order to study its effect on inhibiting prostate cancer (PCa) cell growth and invasion. Immunohistochemical analyses of EZH2 was performed in tumor tissue samples from PCa and benign prostate hyperplasia (BPH). The human telomerase reverse transcriptase (hTERT) promoter was chosen to transcriptionally control EZH2 gene expression to obtain adenoviral replication (Ad‑hTERT...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Promotion of ovarian cancer cell invasion, migration and colony formation by the miR ‑21/Wnt/CD44v6 pathway.
Promotion of ovarian cancer cell invasion, migration and colony formation by the miR‑21/Wnt/CD44v6 pathway. Oncol Rep. 2019 May 09;: Authors: Wang Y, Yang X, Yuan M, Xian S, Zhang L, Yang D, Cheng Y Abstract Ovarian cancer (OC) has the highest mortality rate among female malignant tumors, and OC commonly relapses and metastasizes. The mechanisms underlying the occurrence and development of ovarian cancer are numerous and complicated. The aim of the present study was to explore an important molecular mechanism that may provide a theoretical basis for the clinical treatment of ovarian cancer. In the pr...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑21 inhibitor facilitates the anticancer activity of doxorubicin loaded nanometer in melanoma.
In this study, in vitro and animal models were used to explore the effect of DLN combined with miR‑21 inhibitor on melanoma cells. The data demonstrated that treatment with 5 µl DLN (final concentration of doxorubicin 5 mg/ml) for 72 h effectively inhibited melanoma cell growth (~75% inhibition). The experiments were then divided into five groups: Control group, vector group, DLN group, miR‑21 inhibitor group and miR‑21 inhibitor + DLN group. Compared with the control group, DLN (5 µl) or miR‑21 inhibitor significantly reduced migration and invasion of melanoma cells, promoted apoptosis and arrested cel...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cytokeratin 18 regulates the transcription and alternative splicing of apoptotic ‑related genes and pathways in HeLa cells.
In conclusion, the present study indicated that CK18 played a role in apoptosis, which may be mediated via a feed‑back regulation loop and may involve regulation of transcription and alternative splicing of a number of genes in apoptotic pathways. PMID: 31115582 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12.
miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12. Oncol Rep. 2019 May 13;: Authors: Zhang J, Xu S, Xu J, Li Y, Zhang J, Zhang J, Lu X Abstract A growing body of evidence implicates aberrant expression of microRNAs (miRNAs) and dysregulation of mRNA translation in the development and growth of cancer cells. However, little is known about the mechanisms of action of miRNAs in glioma, the most common form of adult‑onset malignant brain tumor. In the present study, the expression and function of miR‑767‑5p were examined in human glioblastoma multiforme (GBM) tissue speci...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The combination of temsirolimus and chloroquine increases radiosensitivity in colorectal cancer cells.
In conclusion, the combination of TEM and CQ increased radiosensitivity in CRC cells through co‑inhibition of mTOR and autophagy. PMID: 31059051 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR ‑384/pleiotrophin axis.
Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis. Oncol Rep. 2019 Apr 24;: Authors: Yao Y, Rao C, Zheng G, Wang S Abstract Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid that has been found to exhibit anticancer properties in certain types of cancers. In the present study, the role of luteolin and its underlying mechanisms were explored in colorectal cancer (CRC) cells. First, the effects of luteolin on CRC cells proliferation, migration and invasion were examined by CCK‑8, wound healing and Transwell assays, respectively. It was...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

RUNX family: Oncogenes or tumor suppressors (Review).
Authors: Otálora-Otálora BA, Henríquez B, López-Kleine L, Rojas A Abstract Runt‑related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, s...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fingolimod sensitizes EGFR wild ‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest.
Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest. Oncol Rep. 2019 May 02;: Authors: Ota K, Okuma T, Lorenzo A, Yokota A, Hino H, Kazama H, Moriya S, Takano N, Hiramoto M, Miyazawa K Abstract Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are not effective i...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LRIG1 ‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV‑DNA and p16INK4a status.
LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV‑DNA and p16INK4a status. Oncol Rep. 2019 May 02;: Authors: Stefansson K, Oda H, Öfverman C, Lundin E, Hedman H, Lindquist D Abstract The present study was conducted to investigate the possible prognostic value of molecular markers LRIG1‑2 and LIM domain 7 protein (LMO7) in vulvar squamous cell carcinoma (VSCC) and their possible correlation to human papilloma virus (HPV)‑ and p16INK4a‑status of the tumors. Patients diagnosed with VSCC at the University Hospital of Umeå...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Prospective molecular mechanism of COL5A1 in breast cancer based on a microarray, RNA sequencing and immunohistochemistry.
Authors: Wu M, Sun Q, Mo CH, Pang JS, Hou JY, Pang LL, Lu HP, Dang YW, Fang SJ, Tang D, Chen G, Feng ZB Abstract Breast cancer (BC) has a complex etiology and pathogenesis, and is the most common malignant tumor type in females, in USA in 2018, yet its relevant molecular mechanisms remain largely unknown. The collagen type V α‑1 chain (COL5A1) gene is differentially expressed in renal and ovarian cancer. Using bioinformatics methods, COL5A1 was determined to also be a significant gene in BC, but its association with BC has not been sufficiently reported. COL5A1 microarray and relevant clinical data were col...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The targeting of non ‑coding RNAs by curcumin: Facts and hopes for cancer therapy (Review).
The targeting of non‑coding RNAs by curcumin: Facts and hopes for cancer therapy (Review). Oncol Rep. 2019 May 03;: Authors: Liu Y, Sun H, Makabel B, Cui Q, Li J, Su C, Ashby CR, Chen Z, Zhang J Abstract Curcumin [(1E,6E)‑1,7‑bis(4‑hydroxy‑3‑-methoxyphenyl) hepta‑1,6‑diene‑3,5‑dione] is a natural polyphenol that is derived from the turmeric plant (curcuma longa L.). Curcumin is widely used in food coloring, preservatives, and condiments. Curcumin possesses anti‑tumor, anti‑oxidative and anti‑inflammatory efficacy, as well as other pharmacological effects. Emerging evidence ind...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CtBP1 interacts with SOX2 to promote the growth, migration and invasion of lung adenocarcinoma.
Authors: Liu Y, Bian T, Feng J, Qian L, Li X, Zhang Q, Zhang J, Jiang D, Liu J, Shi J Abstract Carboxyl‑terminal binding protein 1 (CtBP1) is overexpressed in many types of solid tumors and has been found to be functionally associated with proliferation, migration, invasion and drug resistance of cancer cells. However, its expression pattern and functions in lung adenocarcinoma remain unclear. In the present study, we observed that the expression of CtBP1 was upregulated in the lung adenocarcinoma tissues of patients with lymph node metastasis and that its overexpression was correlated with tumor differentiation,...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Resveratrol ‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice.
Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice. Oncol Rep. 2019 Apr 25;: Authors: Mikami S, Ota I, Masui T, Uchiyama T, Okamoto H, Kimura T, Takasawa S, Kitahara T Abstract Identifying the key molecules that enhance chemo‑ and radiosensitivity in head and neck squamous cell carcinoma (HNSCC) as well as reliable biomarkers for predicting recurrence and metastasis would be desirable to improve the prognosis of HNSCC. Previously, we have reported that Regenerating gene III (REG III) expression was associated with an improved surv...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Improving lung cancer treatment: Hyaluronic acid ‑modified and glutathione‑responsive amphiphilic TPGS‑doxorubicin prodrug‑entrapped nanoparticles.
Improving lung cancer treatment: Hyaluronic acid‑modified and glutathione‑responsive amphiphilic TPGS‑doxorubicin prodrug‑entrapped nanoparticles. Oncol Rep. 2019 May 02;: Authors: Lu G, Cao L, Zhu C, Xie H, Hao K, Xia N, Wang B, Zhang Y, Liu F Abstract Lung cancer nanotherapeutics aim to overcome the limitations of conventional therapeutic methods. In the present study, a self‑assembled amphiphilic prodrug‑based nanocarrier delivery system was developed that exhibited high therapeutic efficiency. D‑alpha‑tocopheryl polyethylene glycol 1000 succinate (TPGS) conjugated to doxorubicin (DO...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tranilast enhances the effect of anticancer agents in osteosarcoma.
In conclusion, tranilast has a cytostatic effect on osteosarcoma cells and enhances the effect of anticancer drugs, especially cisplatin. Enhanced sensitivity to cisplatin was mediated by increased apoptosis through G2/M arrest. Since tranilast has been clinically approved and has few adverse effects, clinical trials of osteosarcoma chemotherapy in combination with tranilast are expected. PMID: 31059083 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL ‑6 and VEGF from colon cancer‑associated fibroblasts.
Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL‑6 and VEGF from colon cancer‑associated fibroblasts. Oncol Rep. 2019 May 02;: Authors: Ando N, Hara M, Shiga K, Yanagita T, Takasu K, Nakai N, Maeda Y, Hirokawa T, Takahashi H, Ishiguro H, Matsuo Y, Takiguchi S Abstract Eicosapentaenoic acid (EPA) improves interleukin (IL)‑6 hypercytokinemia in patients with advanced cancer due to its anti‑inflammatory effects. This EPA mechanism has been revealed to lead to several anticancer effects. While the effects of EPA on cancer cells have been investigated, particularly in terms...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

125I radiation downregulates TRPV1 expression through miR ‑1246 in neuroblastoma cells.
125I radiation downregulates TRPV1 expression through miR‑1246 in neuroblastoma cells. Oncol Rep. 2019 Apr 22;: Authors: Zhang D, Xu H, Wang Y, Wang K, Wang Y, Wu B, Zhu J, Peng L, Gao J, Li Z Abstract Iodine‑125 (125I) seed radiation applied around the celiac ganglion can relieve the refractory pain in pancreatic cancer. In an in vitro cell radiation model of human neuroblastoma cell lines, the impact of 125I radiation on the expression of transient receptor potential vanilloid‑1 (TRPV1) was investigated. The results indicated that the radiation delivering doses 3.12 Gy significantly reduced cel...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of tesmin (MTL5) in non ‑small cell lung cancer: A preliminary study.
Expression of tesmin (MTL5) in non‑small cell lung cancer: A preliminary study. Oncol Rep. 2019 May 02;: Authors: Grzegrzolka J, Gomulkiewicz A, Olbromski M, Glatzel-Plucinska N, Piotrowska A, Ratajczak-Wielgomas K, Rzechonek A, Podhorska-Okolow M, Krawczuk Z, Dziegiel P Abstract Lung cancer is the most commonly diagnosed cancer and the most frequent cause of death worldwide. Tesmin (testis‑specific metallothionein‑like protein; MTL‑5) is a 60‑kDa protein which has cysteine‑rich motifs (CXC domain), characteristic of metallothioneins (MTs). Tesmin expression has been observed in germ cells ...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CDK6 overexpression resulted from microRNA ‑320d downregulation promotes cell proliferation in diffuse large B‑cell lymphoma.
In conclusion, CDK6 overexpression in DLBCL may result from miRNA‑320d downregulation and subsequent loss of inhibition of cell proliferation, suggesting that miRNA‑320d may be a potential therapeutic target for the treatment of DLBCL with high CDK6 expression. PMID: 31059102 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research