Engineered human mesenchymal stem cells for neuroblastoma therapeutics.
Authors: Nieddu V, Piredda R, Bexell D, Barton J, Anderson J, Sebire N, Kolluri K, Janes SM, Karteris E, Sala A Abstract Drug-resistant neuroblastoma remains a major challenge in paediatric oncology and novel and less toxic therapeutic approaches are urgently needed to improve survival and reduce the side effects of traditional therapeutic interventions. Mesenchymal stem cells (MSCs) are an attractive candidate for cell and gene therapy since they are recruited by and able to infiltrate tumours. This feature has been exploited by creating genetically modified MSCs that are able to combat cancer by delivering therap...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Radixin knockdown improves the accumulation and efficiency of methotrexate in tumor cells.
In conclusion, the present study provides information on radixin as a target molecule for the modulation of MRP activity in tumor cells. PMID: 31115547 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ZNF492 and GPR149 methylation patterns as prognostic markers for clear cell renal cell carcinoma: Array ‑based DNA methylation profiling.
ZNF492 and GPR149 methylation patterns as prognostic markers for clear cell renal cell carcinoma: Array‑based DNA methylation profiling. Oncol Rep. 2019 May 07;: Authors: Kim YJ, Jang W, Piao XM, Yoon HY, Byun YJ, Kim JS, Kim SM, Lee SK, Seo SP, Kang HW, Kim WT, Yun SJ, Shon HS, Ryu KH, Kim SW, Ha YS, Yoon GS, Lee SC, Kwon TG, Kim WJ Abstract The present study aimed to identify novel methylation markers of clear cell renal cell carcinoma (ccRCC) using microarray methylation analysis and evaluate their prognostic relevance in patient samples. To identify cancer‑specific methylated biomarkers, microa...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Investigation of the clinical significance and prospective molecular mechanisms of cystatin genes in patients with hepatitis B virus ‑related hepatocellular carcinoma.
Investigation of the clinical significance and prospective molecular mechanisms of cystatin genes in patients with hepatitis B virus‑related hepatocellular carcinoma. Oncol Rep. 2019 May 09;: Authors: Zhou X, Wang X, Huang K, Liao X, Yang C, Yu T, Liu J, Han C, Zhu G, Su H, Qin W, Han Q, Liu Z, Huang J, Gong Y, Ye X, Peng T Abstract The present study aimed to investigate the clinical significance and prospective molecular mechanism of cystatin (CST) genes in patients with hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC). The role of CST genes in the molecular mechanism of HCC was reve...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Differential gene methylation patterns in cancerous and non ‑cancerous cells.
Differential gene methylation patterns in cancerous and non‑cancerous cells. Oncol Rep. 2019 May 15;: Authors: Kamińska K, Białkowska A, Kowalewski J, Huang S, Lewandowska MA Abstract Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present study was to characterize the prostate cancer malignant transformation model using the CpG island met...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Annexin  A2 regulates glioma cell proliferation through the STAT3‑cyclin D1 pathway.
Annexin A2 regulates glioma cell proliferation through the STAT3‑cyclin D1 pathway. Oncol Rep. 2019 May 09;: Authors: Chen L, Lin L, Xian N, Zheng Z Abstract Annexin A2 (ANXA2) acts as a calcium‑dependent phospholipid‑binding protein that is widely expressed in vertebrate cells and has abnormally high expression in various tumor cells. However, the detailed molecular mechanism underlying the effects of ANXA2 on glioma cells remains unclear. The present study aimed to investigate the role and underlying molecular mechanisms of ANXA2 in glioma cell proliferation. The results revealed that...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Small RNA sequencing revealed aberrant piRNA expression profiles in colorectal cancer.
Authors: Yin J, Qi W, Ji CG, Zhang DX, Xie XL, Ding Q, Jiang XY, Han J, Jiang HQ Abstract Piwi‑interacting RNAs (piRNAs), a novel class of non‑coding RNAs, are enriched in germ cells and implicated in spermatogenesis. Emerging evidence demonstrated deregulated expression of piRNAs in numerous tumor types. However, changes in piRNA expression profiles in colorectal cancer (CRC) have not yet been investigated. In the present study, small RNA sequencing was used to evaluate the differences in piRNA expression profiles between CRC and adjacent non‑tumor tissues, as well as to screen for differentially expressed p...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Intratumoral injection of dendritic cells overexpressing interleukin ‑12 inhibits melanoma growth.
Intratumoral injection of dendritic cells overexpressing interleukin‑12 inhibits melanoma growth. Oncol Rep. 2019 May 21;: Authors: Yao W, Li Y, Zeng L, Zhang X, Zhou Z, Zheng M, Wan H Abstract The present study aimed to investigate the antitumor effects of an intratumoral injection of dendritic cells (DCs) overexpressing interleukin-12 (IL‑12) on melanoma. DCs, isolated from mouse spleen, were gene‑modified using an IL‑12 overexpression vector. Melanoma B6 cells were injected into C57BL/6 mice to generate tumors. Thereafter, DCs overexpressing IL‑12 were injected into the tumors, and tumor v...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MEIS2 promotes cell migration and invasion in colorectal cancer.
Authors: Wan Z, Chai R, Yuan H, Chen B, Dong Q, Zheng B, Mou X, Pan W, Tu Y, Yang Q, Tu S, Hu X Abstract Colorectal cancer (CRC) is one of the most common types of malignancy worldwide. Distant metastasis is a key cause of CRC‑associated mortality. MEIS2 has been identified to be dysregulated in several types of human cancer. However, the mechanisms underlying the regulatory role of MEIS2 in CRC metastasis remain largely unknown. For the first time, the present study demonstrated that MEIS2 serves a role as a promoter of metastasis in CRC. In vivo and in vitro experiments revealed that knockdown of MEIS2 signific...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of miR ‑181a on the biological function of multiple myeloma.
Effects of miR‑181a on the biological function of multiple myeloma. Oncol Rep. 2019 May 15;: Authors: Liu N, Yang J, Yuan R, Peng J, Liu L, Guo X Abstract The present study aimed to investigate the role of miR‑181a in multiple myeloma (MM) cell lines. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect the expression of microRNA (miR)‑181a. The MM cell line RPMI 8226 stably transduced with miR‑181a mimics or inhibitor was established via lentiviral vectors. A Cell Counting Kit‑8 proliferation assay, flow cytometry and a Transwell assay were conducted ...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑497 suppresses malignant phenotype in non‑small cell lung cancer via targeting KDR.
miR‑497 suppresses malignant phenotype in non‑small cell lung cancer via targeting KDR. Oncol Rep. 2019 May 16;: Authors: Xia Y, Hu C, Lian L, Hui K, Wang L, Qiao Y, Liu L, Liang L, Jiang X Abstract The aim of the present study was to evaluate the expression of microRNA‑497 (miR‑497) in non‑small cell lung cancer (NSCLC) tissues and cell lines, and to investigate possible mechanisms associated with its regulatory role on cell behaviors. The expression level of miR‑497 was evaluated in 15 cases of NSCLC tissues and 8 adjacent normal tissues, and in 8 NSCLC cell lines, including H1975, A549, ...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HOXC10 overexpression promotes cell proliferation and migration in gastric cancer.
Authors: Kim J, Bae DH, Kim JH, Song KS, Kim YS, Kim SY Abstract Homeodomain‑containing gene 10 (HOXC10) is a member of the homeobox transcription factors that plays an important role in the development of multicellular organisms. HOXC10 is overexpressed in a variety of human cancers, and recent studies have revealed that HOXC10 is upregulated in gastric cancer as well. However, its mechanism of action is not fully understood, thus, the role of HOXC10 was investigated in the present study in human gastric cancer. First, HOXC10 expression was revealed to be significantly increased in gastric cancer tissues compare...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Conditionally replicative adenovirus carrying shRNA targeting EZH2 inhibits prostate cancer growth and invasion.
Authors: Xu SG, Yu JJ, Shi Q, Niu Q, Guo Z, Guo BY, Zhou GC, Gu X, Wu YX Abstract The present study aimed to construct conditionally replicative adenovirus (CRAds) carrying small hairpin (sh)RNA targeting enhancer of zeste homolog 2 (EZH2), in order to study its effect on inhibiting prostate cancer (PCa) cell growth and invasion. Immunohistochemical analyses of EZH2 was performed in tumor tissue samples from PCa and benign prostate hyperplasia (BPH). The human telomerase reverse transcriptase (hTERT) promoter was chosen to transcriptionally control EZH2 gene expression to obtain adenoviral replication (Ad‑hTERT...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Promotion of ovarian cancer cell invasion, migration and colony formation by the miR ‑21/Wnt/CD44v6 pathway.
Promotion of ovarian cancer cell invasion, migration and colony formation by the miR‑21/Wnt/CD44v6 pathway. Oncol Rep. 2019 May 09;: Authors: Wang Y, Yang X, Yuan M, Xian S, Zhang L, Yang D, Cheng Y Abstract Ovarian cancer (OC) has the highest mortality rate among female malignant tumors, and OC commonly relapses and metastasizes. The mechanisms underlying the occurrence and development of ovarian cancer are numerous and complicated. The aim of the present study was to explore an important molecular mechanism that may provide a theoretical basis for the clinical treatment of ovarian cancer. In the pr...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑21 inhibitor facilitates the anticancer activity of doxorubicin loaded nanometer in melanoma.
In this study, in vitro and animal models were used to explore the effect of DLN combined with miR‑21 inhibitor on melanoma cells. The data demonstrated that treatment with 5 µl DLN (final concentration of doxorubicin 5 mg/ml) for 72 h effectively inhibited melanoma cell growth (~75% inhibition). The experiments were then divided into five groups: Control group, vector group, DLN group, miR‑21 inhibitor group and miR‑21 inhibitor + DLN group. Compared with the control group, DLN (5 µl) or miR‑21 inhibitor significantly reduced migration and invasion of melanoma cells, promoted apoptosis and arrested cel...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cytokeratin 18 regulates the transcription and alternative splicing of apoptotic ‑related genes and pathways in HeLa cells.
In conclusion, the present study indicated that CK18 played a role in apoptosis, which may be mediated via a feed‑back regulation loop and may involve regulation of transcription and alternative splicing of a number of genes in apoptotic pathways. PMID: 31115582 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12.
miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12. Oncol Rep. 2019 May 13;: Authors: Zhang J, Xu S, Xu J, Li Y, Zhang J, Zhang J, Lu X Abstract A growing body of evidence implicates aberrant expression of microRNAs (miRNAs) and dysregulation of mRNA translation in the development and growth of cancer cells. However, little is known about the mechanisms of action of miRNAs in glioma, the most common form of adult‑onset malignant brain tumor. In the present study, the expression and function of miR‑767‑5p were examined in human glioblastoma multiforme (GBM) tissue speci...
Source: Oncology Reports - May 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The combination of temsirolimus and chloroquine increases radiosensitivity in colorectal cancer cells.
In conclusion, the combination of TEM and CQ increased radiosensitivity in CRC cells through co‑inhibition of mTOR and autophagy. PMID: 31059051 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR ‑384/pleiotrophin axis.
Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis. Oncol Rep. 2019 Apr 24;: Authors: Yao Y, Rao C, Zheng G, Wang S Abstract Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid that has been found to exhibit anticancer properties in certain types of cancers. In the present study, the role of luteolin and its underlying mechanisms were explored in colorectal cancer (CRC) cells. First, the effects of luteolin on CRC cells proliferation, migration and invasion were examined by CCK‑8, wound healing and Transwell assays, respectively. It was...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

RUNX family: Oncogenes or tumor suppressors (Review).
Authors: Otálora-Otálora BA, Henríquez B, López-Kleine L, Rojas A Abstract Runt‑related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, s...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fingolimod sensitizes EGFR wild ‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest.
Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest. Oncol Rep. 2019 May 02;: Authors: Ota K, Okuma T, Lorenzo A, Yokota A, Hino H, Kazama H, Moriya S, Takano N, Hiramoto M, Miyazawa K Abstract Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are not effective i...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LRIG1 ‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV‑DNA and p16INK4a status.
LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV‑DNA and p16INK4a status. Oncol Rep. 2019 May 02;: Authors: Stefansson K, Oda H, Öfverman C, Lundin E, Hedman H, Lindquist D Abstract The present study was conducted to investigate the possible prognostic value of molecular markers LRIG1‑2 and LIM domain 7 protein (LMO7) in vulvar squamous cell carcinoma (VSCC) and their possible correlation to human papilloma virus (HPV)‑ and p16INK4a‑status of the tumors. Patients diagnosed with VSCC at the University Hospital of Umeå...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Prospective molecular mechanism of COL5A1 in breast cancer based on a microarray, RNA sequencing and immunohistochemistry.
Authors: Wu M, Sun Q, Mo CH, Pang JS, Hou JY, Pang LL, Lu HP, Dang YW, Fang SJ, Tang D, Chen G, Feng ZB Abstract Breast cancer (BC) has a complex etiology and pathogenesis, and is the most common malignant tumor type in females, in USA in 2018, yet its relevant molecular mechanisms remain largely unknown. The collagen type V α‑1 chain (COL5A1) gene is differentially expressed in renal and ovarian cancer. Using bioinformatics methods, COL5A1 was determined to also be a significant gene in BC, but its association with BC has not been sufficiently reported. COL5A1 microarray and relevant clinical data were col...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The targeting of non ‑coding RNAs by curcumin: Facts and hopes for cancer therapy (Review).
The targeting of non‑coding RNAs by curcumin: Facts and hopes for cancer therapy (Review). Oncol Rep. 2019 May 03;: Authors: Liu Y, Sun H, Makabel B, Cui Q, Li J, Su C, Ashby CR, Chen Z, Zhang J Abstract Curcumin [(1E,6E)‑1,7‑bis(4‑hydroxy‑3‑-methoxyphenyl) hepta‑1,6‑diene‑3,5‑dione] is a natural polyphenol that is derived from the turmeric plant (curcuma longa L.). Curcumin is widely used in food coloring, preservatives, and condiments. Curcumin possesses anti‑tumor, anti‑oxidative and anti‑inflammatory efficacy, as well as other pharmacological effects. Emerging evidence ind...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CtBP1 interacts with SOX2 to promote the growth, migration and invasion of lung adenocarcinoma.
Authors: Liu Y, Bian T, Feng J, Qian L, Li X, Zhang Q, Zhang J, Jiang D, Liu J, Shi J Abstract Carboxyl‑terminal binding protein 1 (CtBP1) is overexpressed in many types of solid tumors and has been found to be functionally associated with proliferation, migration, invasion and drug resistance of cancer cells. However, its expression pattern and functions in lung adenocarcinoma remain unclear. In the present study, we observed that the expression of CtBP1 was upregulated in the lung adenocarcinoma tissues of patients with lymph node metastasis and that its overexpression was correlated with tumor differentiation,...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Resveratrol ‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice.
Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice. Oncol Rep. 2019 Apr 25;: Authors: Mikami S, Ota I, Masui T, Uchiyama T, Okamoto H, Kimura T, Takasawa S, Kitahara T Abstract Identifying the key molecules that enhance chemo‑ and radiosensitivity in head and neck squamous cell carcinoma (HNSCC) as well as reliable biomarkers for predicting recurrence and metastasis would be desirable to improve the prognosis of HNSCC. Previously, we have reported that Regenerating gene III (REG III) expression was associated with an improved surv...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Improving lung cancer treatment: Hyaluronic acid ‑modified and glutathione‑responsive amphiphilic TPGS‑doxorubicin prodrug‑entrapped nanoparticles.
Improving lung cancer treatment: Hyaluronic acid‑modified and glutathione‑responsive amphiphilic TPGS‑doxorubicin prodrug‑entrapped nanoparticles. Oncol Rep. 2019 May 02;: Authors: Lu G, Cao L, Zhu C, Xie H, Hao K, Xia N, Wang B, Zhang Y, Liu F Abstract Lung cancer nanotherapeutics aim to overcome the limitations of conventional therapeutic methods. In the present study, a self‑assembled amphiphilic prodrug‑based nanocarrier delivery system was developed that exhibited high therapeutic efficiency. D‑alpha‑tocopheryl polyethylene glycol 1000 succinate (TPGS) conjugated to doxorubicin (DO...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tranilast enhances the effect of anticancer agents in osteosarcoma.
In conclusion, tranilast has a cytostatic effect on osteosarcoma cells and enhances the effect of anticancer drugs, especially cisplatin. Enhanced sensitivity to cisplatin was mediated by increased apoptosis through G2/M arrest. Since tranilast has been clinically approved and has few adverse effects, clinical trials of osteosarcoma chemotherapy in combination with tranilast are expected. PMID: 31059083 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL ‑6 and VEGF from colon cancer‑associated fibroblasts.
Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL‑6 and VEGF from colon cancer‑associated fibroblasts. Oncol Rep. 2019 May 02;: Authors: Ando N, Hara M, Shiga K, Yanagita T, Takasu K, Nakai N, Maeda Y, Hirokawa T, Takahashi H, Ishiguro H, Matsuo Y, Takiguchi S Abstract Eicosapentaenoic acid (EPA) improves interleukin (IL)‑6 hypercytokinemia in patients with advanced cancer due to its anti‑inflammatory effects. This EPA mechanism has been revealed to lead to several anticancer effects. While the effects of EPA on cancer cells have been investigated, particularly in terms...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

125I radiation downregulates TRPV1 expression through miR ‑1246 in neuroblastoma cells.
125I radiation downregulates TRPV1 expression through miR‑1246 in neuroblastoma cells. Oncol Rep. 2019 Apr 22;: Authors: Zhang D, Xu H, Wang Y, Wang K, Wang Y, Wu B, Zhu J, Peng L, Gao J, Li Z Abstract Iodine‑125 (125I) seed radiation applied around the celiac ganglion can relieve the refractory pain in pancreatic cancer. In an in vitro cell radiation model of human neuroblastoma cell lines, the impact of 125I radiation on the expression of transient receptor potential vanilloid‑1 (TRPV1) was investigated. The results indicated that the radiation delivering doses 3.12 Gy significantly reduced cel...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of tesmin (MTL5) in non ‑small cell lung cancer: A preliminary study.
Expression of tesmin (MTL5) in non‑small cell lung cancer: A preliminary study. Oncol Rep. 2019 May 02;: Authors: Grzegrzolka J, Gomulkiewicz A, Olbromski M, Glatzel-Plucinska N, Piotrowska A, Ratajczak-Wielgomas K, Rzechonek A, Podhorska-Okolow M, Krawczuk Z, Dziegiel P Abstract Lung cancer is the most commonly diagnosed cancer and the most frequent cause of death worldwide. Tesmin (testis‑specific metallothionein‑like protein; MTL‑5) is a 60‑kDa protein which has cysteine‑rich motifs (CXC domain), characteristic of metallothioneins (MTs). Tesmin expression has been observed in germ cells ...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CDK6 overexpression resulted from microRNA ‑320d downregulation promotes cell proliferation in diffuse large B‑cell lymphoma.
In conclusion, CDK6 overexpression in DLBCL may result from miRNA‑320d downregulation and subsequent loss of inhibition of cell proliferation, suggesting that miRNA‑320d may be a potential therapeutic target for the treatment of DLBCL with high CDK6 expression. PMID: 31059102 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gene expression profile of cancer stem ‑like cells in the SW480 colon adenocarcinoma cell line.
Gene expression profile of cancer stem‑like cells in the SW480 colon adenocarcinoma cell line. Oncol Rep. 2019 May 02;: Authors: Wang Y, Zhou L, Qing Q, Li Y, Li L, Dong X, Xiao B Abstract Cancer stem cells (CSCs) serve an important role in tumorigenesis, tolerance to treatment, relapse and metastasis. Although the signaling pathways involved in cancer are well known, the molecular mechanisms underlying CSC actions require further investigation. In the present study, a population of colon CSCs with a cluster of differentiation 133 (CD133) surface‑expression phenotype from the human SW480 colon aden...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor ‑type‑dependent effects on the angiogenic abilities of endothelial cells in an in vitro rat cell model.
Tumor‑type‑dependent effects on the angiogenic abilities of endothelial cells in an in vitro rat cell model. Oncol Rep. 2019 May 02;: Authors: Al-Abboodi M, An R, Weber M, Schmid R, Klausing A, Horch RE, Boos AM, Kengelbach-Weigand A Abstract Adequate vascularization is pivotal for tumor progression and metastasis. Tumor angiogenesis is based on a sequence of interactions between the tumor and surrounding cells and the extracellular matrix. It is widely known that a tumor can influence and control its surroundings to create favorable conditions for further growth. To investigate the influence of va...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early ‑stage pancreatic ductal adenocarcinoma.
Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma. Oncol Rep. 2019 Apr 24;: Authors: Yang C, Yu T, Liu Z, Ye X, Liao X, Wang X, Han C, Zhu G, Qin W, Peng T Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, and early diagnosis and assessment may enhance the quality of life and survival of patients. The prognostic value of key family 2 cystatins subunit in PDAC patients remains unknown. The potential molecular roles of family 2 cystatins and related pathways were investigated using bioinformatic...
Source: Oncology Reports - May 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib.
Authors: Yang Z, Zhang J, Lin X, Wu D, Li G, Zhong C, Fang L, Jiang P, Yin L, Zhang L, Bie P, Xie CM Abstract Sorafenib remains the standard care for patients with hepatocellular carcinoma (HCC) even though it has low antitumor efficacy. Protein neddylation is abnormally activated in many types of human cancer. However, whether dysregulation of neddylation is involved in HCC progression and whether targeting neddylation sensitizes HCC cells to sorafenib need to be ascertained. In the present study, it was demonstrated that high expression of neddylation components, neural precursor cell expressed, developmentally d...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Differential expression of tescalcin by modification of promoter methylation controls cell survival in gastric cancer cells.
Authors: Kim TW, Han SR, Kim JT, Yoo SM, Lee MS, Lee SH, Kang YH, Lee HG Abstract The EF‑hand calcium binding protein tescalcin (TESC) is highly expressed in various human and mouse cancer tissues and is therefore considered a potential oncogene. However, the underlying mechanism that governs TESC expression remains unclear. Emerging evidence suggests that TESC expression is under epigenetic regulation. In the present study, the relationship between the epigenetic modification and gene expression of TESC in gastric cancer was investigated. To evaluate the relationship between the methylation and expression of TES...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Heptadecanoic acid inhibits cell proliferation in PC ‑9 non‑small‑cell lung cancer cells with acquired gefitinib resistance.
Heptadecanoic acid inhibits cell proliferation in PC‑9 non‑small‑cell lung cancer cells with acquired gefitinib resistance. Oncol Rep. 2019 Apr 18;: Authors: Xu C, Wu P, Gao J, Zhang L, Ma T, Ma B, Yang S, Shao G, Yu Y, Huang X, Yang X, Zhang B Abstract Non‑small cell lung carcinomas (NSCLC) are common and are the leading cause of cancer‑associated mortality worldwide. Heptadecanoic acid (C17:0) is an odd‑chain saturated fatty acid. The effect of C17:0 on lung cancer has remained elusive. The present study examined the role of C17:0 in the PC‑9 NSCLC cell line and PC‑9 cells with acquir...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Deubiquitinase USP9X regulates the invasion of prostate cancer cells by regulating the ERK pathway and mitochondrial dynamics.
In conclusion, the present study demonstrated that USP9X is downregulated in prostate cancer and functions as an inhibitor of tumor cell invasion, possibly through the regulation of the ERK signaling pathway. PMID: 31002345 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulation of LGMNP1 confers radiotherapy resistance in glioblastoma.
Authors: Xu H, Chen B, Xing J, Wei Z, Liu C, Qiu Y, Lin Y, Ren L Abstract Glioblastoma is a lethal brain tumor type, which is frequently resistant to radiotherapy. The aim of the present study was to explore the function of legumain pseudogene 1 (LGMNP1) on radioresistance in glioblastoma. Reverse transcription‑quantitative PCR was used to detect the relative expression of LGMNP1 in glioma cell lines after radiotherapy. Ectopic expression of LGMNP1 was achieved by transfection of a lentiviral vector. A clonogenic assay was used to determine the colony formation ability following radiotherapy. A comet assay, ...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LRG ‑1 enhances the migration of thyroid carcinoma cells through promotion of the epithelial‑mesenchymal transition by activating MAPK/p38 signaling.
LRG‑1 enhances the migration of thyroid carcinoma cells through promotion of the epithelial‑mesenchymal transition by activating MAPK/p38 signaling. Oncol Rep. 2019 Apr 17;: Authors: Ban Z, He J, Tang Z, Zhang L, Xu Z Abstract Leucine‑rich‑alpha‑2‑glycoprotein 1 (LRG‑1) has been reported to be associated with multiple malignancies. However, its participation in thyroid carcinoma progression remains unclear. In the present study, the biological function and underlying molecular mechanisms of LRG‑1 in thyroid carcinoma were investigated. It was found that LRG‑1 was overexpressed in thyr...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Acquisition of gemcitabine resistance enhances angiogenesis via upregulation of IL ‑8 production in pancreatic cancer.
Acquisition of gemcitabine resistance enhances angiogenesis via upregulation of IL‑8 production in pancreatic cancer. Oncol Rep. 2019 Apr 09;: Authors: Imafuji H, Matsuo Y, Ueda G, Omi K, Hayashi Y, Saito K, Tsuboi K, Morimoto M, Koide S, Ogawa R, Hara M, Takahashi H, Takiguchi S Abstract Gemcitabine (Gem) is widely used as chemotherapy for pancreatic cancer (PaCa), but its effect is not fully satisfactory. One of the reasons for this is the acquisition of Gem resistance (Gem‑R). To elucidate the mechanism of Gem‑R, two Gem‑R PaCa cell lines were established from AsPC‑1 and MIA PaCa‑2 cells...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Propofol may increase caspase and MAPK pathways, and suppress the Akt pathway to induce apoptosis in MA ‑10 mouse Leydig tumor cells.
Propofol may increase caspase and MAPK pathways, and suppress the Akt pathway to induce apoptosis in MA‑10 mouse Leydig tumor cells. Oncol Rep. 2019 Apr 18;: Authors: Kang FC, Wang SC, So EC, Chang MM, Wong KL, Cheng KS, Chen YC, Huang BM Abstract In the western world, there is an increasing trend of occurrence in testicular cancer. Treatment of malignant testicular cancer is primarily combined surgery with various chemical drugs. Propofol has been frequently used as an anesthetic and sedative induction agent, which could modulate different γ‑aminobutyric acid receptors in the central nervous...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulated histamine receptor  H3 promotes tumor growth and metastasis in hepatocellular carcinoma.
Upregulated histamine receptor H3 promotes tumor growth and metastasis in hepatocellular carcinoma. Oncol Rep. 2019 Apr 16;: Authors: Yu D, Zhao J, Wang Y, Hu J, Zhao Q, Li J, Zhu J Abstract Histamine receptor H3 (HRH3) is mainly expressed in the central nervous system, where it is involved in the regulation of the release of various neurotransmitters in the brain. Recent studies have demonstrated that the expression of HRH3 is upregulated in several types of cancer. However, the functional effect of HRH3 on tumor progression remains largely unknown, particularly in hepatocellular carcinoma (HCC)....
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/ β‑catenin pathway.
TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/β‑catenin pathway. Oncol Rep. 2019 Apr 11;: Authors: Mu X, Li H, Zhou L, Xu W Abstract As a major cause of cancer‑associated mortalities, lung cancer is frequently diagnosed in males and females with an incidence ratio of 2.1:1. Tripartite motif 52 (TRIM52), an E3 ubiquitin ligase, has been reported to be involved in various biological functions, including cell proliferation and invasiveness. In the present study, an elevated TRIM52 level was observed in tumor tissues of patients with lung cancer and in lung c...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

1 α,25‑Dihydroxyvitamin D3 restrains stem cell‑like properties of ovarian cancer cells by enhancing vitamin D receptor and suppressing CD44.
In conclusion, 1α,25(OH)2D3 restrains the stem cell‑like properties of ovarian cancer cells by enhancing the expression of VDR, by promoting the expression of β‑catenin in the cytoplasm, and by suppressing the expression of CD44. These findings provide a novel insight into the functions of vitamin D in diminishing the stemness of cancer CSCs. PMID: 31002352 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells.
Authors: Zhao L, Shou H, Chen L, Gao W, Fang C, Zhang P Abstract Epigenetic modifications are closely related to oncogene activation and tumor suppressor gene inactivation. The aim of this study was to determine the effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells. Cell proliferation, metastasis, invasion and apoptosis were respectively determined using Cell Counting Kit‑8 (CCK‑8), wound healing, Transwell and flow cytometric assays. Methylation levels were determined using methylation specific PCR (MSP). Related‑factor expression was detected by conducting real‑time‑qPCR (RT...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DNA methylation of metallothionein genes is associated with the clinical features of renal cell carcinoma.
Authors: Maleckaite R, Zalimas A, Bakavicius A, Jankevicius F, Jarmalaite S, Daniunaite K Abstract Metallothioneins are low‑weight cysteine‑rich proteins responsible for metal ion homeostasis in a cell and, thus, capable of regulating cell proliferation and differentiation. Deregulation of metallothionein genes has been reported in various human tumors. However, their role in renal cell carcinoma (RCC) has been poorly investigated. In the present study, we aimed to evaluate the importance of promoter DNA methylation of selected metallothionein genes for RCC. Based on the initial analysis of kidney renal clear c...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Dynamic contrast enhanced ‑magnetic resonance imaging for the early evaluation of the response to docetaxel in rats with epithelial ovarian cancer.
Dynamic contrast enhanced‑magnetic resonance imaging for the early evaluation of the response to docetaxel in rats with epithelial ovarian cancer. Oncol Rep. 2019 Apr 17;: Authors: Yuan SJ, Qiao TK, Qiang JW, Cai SQ Abstract Dynamic contrast enhanced‑magnetic resonance imaging (DCE‑MRI) contributes to the early detection and prediction of responses to chemotherapy in cancer. The aim of the present study was to investigate the feasibility of quantitative DCE‑MRI parameters for noninvasively predicting the early response to DTX in epithelial ovarian cancer (EOC). In the present study, using 7,12...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Methylation of the promoter region of the MTRR gene in childhood acute lymphoblastic leukemia.
Authors: Bai J, Li L, Li Y, Chen Q, Zhang L, Xie X Abstract Epigenetic analysis of the association between the methylation status of the promoter region of the MTRR (5‑methyltetrahydrofolate‑homocysteine methyltransferase reductase) gene and the risk of acute lymphoblastic leukemia (ALL) in children plays an important role in the early diagnosis, assessment of the malignant degree, treatment and evaluation of the risk of relapse and prognosis of the disease. In the present study, RT‑qPCR was used to detect the mRNA levels of the MTRR and MTHFR (methylenetetrahydrofolate reductase) genes in the bone marrow of ...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research