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miR-16 mimics inhibit TGF- β1-induced epithelial-to-mesenchymal transition via activation of autophagy in non-small cell lung carcinoma cells.
miR-16 mimics inhibit TGF-β1-induced epithelial-to-mesenchymal transition via activation of autophagy in non-small cell lung carcinoma cells. Oncol Rep. 2017 Nov 09;: Authors: Wang H, Zhang Y, Wu Q, Wang YB, Wang W Abstract Autophagy is critical for the metastasis of cancer cells through induction of epithelial-to-mesenchymal transition (EMT). Activation of TGF-β signaling plays a key role in regulating autophagy. miR-16 may be associated with non-small cell lung carcinoma (NSCLC) progression. However, the role of miR-16 in NSCLC cell autophagy in the presence of TGF-β and the underlying...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Enhanced activated T  cell subsets in prostate cancer patients receiving iodine-125 low-dose-rate prostate brachytherapy.
Enhanced activated T cell subsets in prostate cancer patients receiving iodine-125 low-dose-rate prostate brachytherapy. Oncol Rep. 2017 Nov 13;: Authors: Kubo M, Satoh T, Ishiyama H, Tabata KI, Tsumura H, Komori S, Iwamura M, Baba S, Hayakawa K, Kawamura T, Obata F Abstract Radiotherapy (RT) is one of the most important treatments for prostate cancer. Although RT can kill cancer cells through direct and indirect effects of radiation, it occasionally induces an abscopal effect whereby localized radiation treatment is associated with elimination of metastatic cancer at a distance from the irra...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer.
Authors: Yang L, Zha TQ, He X, Chen L, Zhu Q, Wu WB, Nie FQ, Wang Q, Zang CS, Zhang ML, He J, Li W, Jiang W, Lu KH Abstract Pulmonary carcinoma-associated proteins have emerged as crucial players in governing fundamental biological processes such as cell proliferation, apoptosis and metastasis in human cancers. Placenta-specific protein 1 (PLAC1) is a cancer-related protein, which is activated and upregulated in a variety of malignant tissues, including prostate cancer, gastric adenocarcinoma, colorectal, epithelial ovarian and breast cancer. However, its biological role and clinical significance in non-small ...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ITR ‑284 modulates cell differentiation in human chronic myelogenous leukemia K562 cells.
ITR‑284 modulates cell differentiation in human chronic myelogenous leukemia K562 cells. Oncol Rep. 2017 Nov 09;: Authors: Yang JS, Lee CY, Cho HC, Lu CC, Kuo SC, Wen YF, Tsai FJ, Lee MR, Tsai SC Abstract ITR‑284 is a carboxamide analog that can inhibit proliferation in human promyelocytic leukemia HL-60 cells. To understand the effects and molecular mechanisms of ITR‑284 in human erythromyeloblastoid leukemia, we treated K562 cells with different concentrations of ITR‑284 (0, 2, 4, 6, 8 and 10 nM) and all-trans retinoic acid (ATRA) (0, 0.1, 0.5, 1, 5 and 10 µM) for 24 h. T...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of mitochondrial function in the invasiveness of human colon cancer cells.
Authors: Lin CS, Liu LT, Ou LH, Pan SC, Lin CI, Wei YH Abstract We investigated the role of mitochondrial function in the invasiveness of human colorectal cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and appraised the clinical relevance of the alteration of mtDNA copy number in 33 pairs of CRC specimens after surgical resection. Suppression of mitochondrial function was achieved by the exposure of cells to oligomycin A (OA) or by knockdown of mitochondrial transcriptional factor A (TFAM) to evaluate their effects on energy metabolism, reactive oxygen species, protei...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

NRP1-positive lung cancer cells possess tumor-initiating properties.
In conclusion, we demonstrated that NRP1+ lung cancer cells have tumor-initiating properties. NRP1 could be a useful biomarker for tumor-initiating cells in lung cancer tumors. PMID: 29138851 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of miR ‑19a‑3p promotes invasion, migration and bone metastasis via activating TGF‑β signaling in prostate cancer.
Downregulation of miR‑19a‑3p promotes invasion, migration and bone metastasis via activating TGF‑β signaling in prostate cancer. Oncol Rep. 2017 Nov 13;: Authors: Wa Q, Li L, Lin H, Peng X, Ren D, Huang Y, He P, Huang S Abstract Constitutive activation of TGF‑β signaling pathway is a well-documented mechanism responsible for the bone metastasis of prostate cancer (PCa). MicroRNAs (miRNAs) have been reported to be crucial for the activation of TGF‑β signaling via targeting downstream components of TGF‑β signaling pathway. Here, we report that miR‑19a‑3p is downregulat...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Immunogenic tumor cell death induced by chemotherapy in patients with breast cancer and esophageal squamous cell carcinoma.
Authors: Aoto K, Mimura K, Okayama H, Saito M, Chida S, Noda M, Nakajima T, Saito K, Abe N, Ohki S, Ohtake T, Takenoshita S, Kono K Abstract It has been reported that chemo-radiotherapy can induce immunogenic tumor cell death (ICD), which triggers T-cell immunity mainly mediated by high-mobility group box 1 protein (HMGB1) and calreticulin. However, there is still limited information to support this theory relating to chemotherapy alone. In the present study, the expression of HMGB1 and calreticulin was evaluated by immunohistochemistry in pre-treatment biopsy specimens and surgically resected specimens, which...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Liver kinase  B1 restoration promotes exosome secretion and motility of lung cancer cells.
Liver kinase B1 restoration promotes exosome secretion and motility of lung cancer cells. Oncol Rep. 2017 Nov 09;: Authors: Zhang C, Xiao X, Chen M, Aldharee H, Chen Y, Long W Abstract Liver kinase B1 (LKB1) regulates a variety of cellular functions, including cell polarity, energy metabolism and cell growth, by targeting multiple signaling pathways such as AMPK/mTOR and p53. LKB1 functions as a tumor suppressor in sporadic cancers including lung cancer. Extracellular vesicles such as exosomes secreted by cancer cells modulate the tumor microenvironment and progression by targeting both tumor...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma.
Authors: Kurata A, Yamada M, Ohno SI, Inoue S, Hashimoto H, Fujita K, Takanashi M, Kuroda M Abstract Scirrhous type gastric cancer is characterized by diffuse infiltration of poorly differentiated adenocarcinoma cells and poor prognosis. Although association of poorly differentiated histology with reduction in E-cadherin expression, as well as association of microRNA (miR)-200c with E-cadherin through regulation of ZEB1/2, has been reported, participation of miR-200c in gastric carcinogenesis is not fully understood. We used 6 cell lines originating from gastric cancers, and investigated levels of miR-200c along wi...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing of vacuolar ATPase c  subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner. Oncol Rep. 2017 Nov 10;: Authors: Zou P, Yang Y, Xu X, Liu B, Mei F, You J, Liu Q, Pei F Abstract Vacuolar ATPase (V-ATPase), widespread in eukaryotic cells, is extensively expressed in many highly metastatic tumors, of which the V-ATPase c subunit ATP6V0C is particularly associated with the invasion and metastasis of cancer. ATP6V0C was directly found to interact with LASS2/TMSG1 which is a new tumor metastasis inhibitory gene identified by our laboratory in...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HMGA2 facilitates epithelial-mesenchymal transition in renal cell carcinoma by regulating the TGF- β/Smad2 signaling pathway.
HMGA2 facilitates epithelial-mesenchymal transition in renal cell carcinoma by regulating the TGF-β/Smad2 signaling pathway. Oncol Rep. 2017 Nov 10;: Authors: Kou B, Liu W, Tang X, Kou Q Abstract High-mobility group AT-hook 2 (HMGA2), a member of the high mobility group family, has been reported to correlate with cancer progression. However, there is no report concerning the correlation between HMGA2 and metastasis in renal cell carcinoma. In the present study, we found that HMGA2 was highly expressed in five renal cell carcinoma cell lines compared with that in the normal renal tubular epithelial...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of xanthohumol on Th1/Th2 balance in a breast cancer mouse model.
Authors: Zhang W, Pan Y, Gou P, Zhou C, Ma L, Liu Q, Du Y, Yang J, Wang Q Abstract Xanthohumol (XN), a prenylflavonoid found in the hop plant, Humulus lupulus, exhibits a variety of biological activities. Numerous studies have reported that XN inhibits the growth of many types of cancer cells, but the effects of XN on tumor immunity have not yet been studied. We explored the effect of XN on Th1/Th2 balance and the underlying mechanism based on a BALB/c-4T1 breast cancer mouse model. The results showed that XN significantly slowed down tumor growth and inhibited expression of antitumor proliferation protein Ki-67 as...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cepharanthine exhibits a potent anticancer activity in p53-mutated colorectal cancer cells through upregulation of p21Waf1/Cip1.
This study aimed to evaluate the anticancer activity of CEP in p53 mutant versus p53 wild-type colorectal cancer cells and determine its underlying mechanisms of action. Our results showed that CEP induced colorectal cancer cell death in a concentration-dependent manner. Remarkably, CEP was more effective in controlling the growth of the p53 mutant colorectal cancer cell lines, HT‑29 and SW-620, than the p53 wild-type colorectal cancer cell lines, COLO‑205 and HCT-116. Further studies on the underlying mechanisms revealed that CEP could induce cell cycle arrest and apoptosis in both HT‑29 and COLO‑205 cells. Treatm...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

c-Fos mediates α1, 2-fucosyltransferase 1 and Lewis y expression in response to TGF-β1 in ovarian cancer.
c-Fos mediates α1, 2-fucosyltransferase 1 and Lewis y expression in response to TGF-β1 in ovarian cancer. Oncol Rep. 2017 Dec;38(6):3355-3366 Authors: Hao Y, Zhu L, Yan L, Liu J, Liu D, Gao N, Tan M, Gao S, Lin B Abstract FUT1 is a key rate-limiting enzyme in the synthesis of Lewis y, a membrane-associated carbohydrate antigen. The aberrant upregulation of FUT1 and Lewis y antigen is related to proliferation, invasion and prognosis in malignant epithelial tumors. A c-Fos/activator protein-1 (AP-1) binding site was found in the FUT1 promoter. However, the mechanisms of transcri...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ursodeoxycholic acid suppresses epithelial-mesenchymal transition and cancer stem cell formation by reducing the levels of peroxiredoxin II and reactive oxygen species in pancreatic cancer cells.
In conclusion UDCA suppressed the levels of intracellular ROS and Prx2 and it decreased EMT and stem cell formation in pancreatic cancer cells. Therefore, UDCA may provide favorable therapeutic benefits, through its antioxidant effects, for patients with pancreatic cancer. PMID: 29130098 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulation of miR-542-3p inhibits the growth and invasion of human colon cancer cells through PI3K/AKT/survivin signaling.
Authors: Yang C, Wang MH, Zhou JD, Chi Q Abstract The present study was designed to assess the expression of microRNA-542-3p (miR-542-3p) in human colon cancer and investigate the possible molecular mechanisms underlying the effect of miR-542-3p on the growth and invasion of colon cancer cells. We found that miR-542-3p expression was downregulated in colon cancer patient tissues, compared with that observed in the control group. Silencing of miR‑542-3p expression significantly promoted cell viability and inhibited apoptosis. In addition, overexpression of miR-542-3p significantly reduced cell viability and promot...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance.
Authors: Chang W, Yu Z, Tian M, Lin X Abstract Immature colon carcinoma transcript-1 (ICT1) is a newly identified oncogene, which regulates proliferation, cell cycle progression and apoptosis of cancer cells. However, the clinical significance, biological function and underlying mechanisms of ICT1 in hepatocellular carcinoma (HCC) remain poorly known. In the present study, we showed that the expression of ICT1 in HCC tissues were notably overexpressed compared to corresponding non-tumor tissues. Accordingly, the relative levels of ICT1 were upregulated in HCC cell lines compared with LO2 cells. The positive express...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The recombinant EGFR/CD13 bi-targeted fusion protein induces apoptosis and blocks tube formation.
In conclusion, the EGFR/CD13 bi-targeted fusion protein ER(Fv)‑LDP-NGR displays multi-functional characteristics, acting on both cancer cells and endothelial cells. It might be an effective agent for targeted cancer therapy. PMID: 29130101 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of lncRNA-XIST enhances the chemosensitivity of NSCLC cells via suppression of autophagy.
This study provides evidence that lncRNA-XIST may be a potential marker of poor response to cisplatin chemotherapy in NSCLC patients and the pathway 'lncRNA-XIST/miR-17/autophagy' may be a promising target for patients with chemoresistant NSCLC. PMID: 29130102 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hypoxia-induced inhibition of the endocannabinoid system in glioblastoma cells.
Authors: Sugimoto N, Ishibashi H, Nakamura H, Yachie A, Ohno-Shosaku T Abstract The endocannabinoid system plays an important role in the regulation of physiological and pathological conditions, including inflammation and cancer. Hypoxia is a fundamental phenomenon for the establishment and maintenance of the microenvironments in various physiological and pathological conditions. However, the influence of hypoxia on the endocannabinoid system is not fully understood. In the present study, we investigated the effects of hypoxia on the endocannabinoid system in malignant brain tumors. We subjected U-87 MG cells,...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of fatty acid synthase is regulated by PGC ‑1α and contributes to increased cell proliferation.
Expression of fatty acid synthase is regulated by PGC‑1α and contributes to increased cell proliferation. Oncol Rep. 2017 Dec;38(6):3497-3506 Authors: Yun SH, Shin SW, Park JI Abstract We previously demonstrated that overexpression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) promotes increased cell proliferation and tumorigenic potential through upregulation of specificity protein 1 (Sp1) and acyl-CoA-binding protein (ACBP). Fatty acid synthase (FASN) is a key enzyme in fatty acid biosynthesis, and its expression in various cancers is associate...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor molecular profiling of NSCLC patients using next generation sequencing.
Authors: Tsoulos N, Papadopoulou E, Metaxa-Mariatou V, Tsaousis G, Efstathiadou C, Tounta G, Scapeti A, Bourkoula E, Zarogoulidis P, Pentheroudakis G, Kakolyris S, Boukovinas I, Papakotoulas P, Athanasiadis E, Floros T, Koumarianou A, Barbounis V, Dinischiotu A, Nasioulas G Abstract Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer and a tumor with a broad spectrum of targeted therapies already available or in clinical trials. Thus, molecular characterization of the tumor using next generation sequencing (NGS) technology, has become a key tool for facilitating treatment decisions and the c...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Molecular alterations of the NF2 gene in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
In conclusion, we provide initial evidence of human primary liver cancers characterized by molecular alterations of NF2/Merlin and the involvement of the Hippo pathway in the pathogenesis of human liver cancer. PMID: 29130106 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A seven-gene prognostic signature for rapid determination of head and neck squamous cell carcinoma survival.
In conclusion, the seven-gene prognostic signature is a reliable and practical prognostic tool for HNSCC. This approach can add prognostic value to clinical characteristics and provides a new possibility for individualized treatment. PMID: 29130107 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclin  D1/MMP2 axis.
miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclin D1/MMP2 axis. Oncol Rep. 2017 Dec;38(6):3522-3530 Authors: Zhao L, Liu L, Dong Z, Xiong J Abstract Valid evidence has demonstrated that microRNAs have critical functions in cancer genesis and tumor progression. In the present study, aberrant expression of microRNA-149 (miR-149) was confirmed in non-small cell lung cancer (NSCLC) tissues. Low expression of miR-149 was associated with malignant clinical features and poor survival. Gain- and loss-of-function experiments demonstrated that miR-...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Deubiquitinase USP9X promotes cell migration, invasion and inhibits apoptosis of human pancreatic cancer.
Authors: Liu L, Yao D, Zhang P, Ding W, Zhang X, Zhang C, Gong S, Zhang Y, Wang J, Sun T, Ren Z Abstract Ubiquitin specific peptidase 9, X-linked (USP9X), a significant regulatory protease in protein ubiquitination, has been proven to act as a proto-oncogene in several types of cancers, such as cervix, colon, breast, brain and lung cancers. The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is extremely poor due to its high invasive and metastatic abilities. Nevertheless, whether USP9X acts as a proto-oncogene or a tumor-suppressor gene in PDAC is controversial and the mechanism of metastas...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF- κB/MMP-9 signaling in monomorphic malignant human glioma cells.
Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-κB/MMP-9 signaling in monomorphic malignant human glioma cells. Oncol Rep. 2017 Dec;38(6):3619-3631 Authors: Lee W, Nam JH, Cho HJ, Lee JY, Cho WK, Kim Υ, We YM, Ma JY, Hoe HS Abstract Previously, we showed that the herbal extract EYK (Epimedium koreanum Nakai) can regulate the immune response. Other studies showed that EYK has beneficial effects in human lung cancer, angiogenesis and Alzheimer's disease (AD). However, it remains unknown whether EYK can affect cancer cell migration and invasi...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-433 inhibits cervical cancer progression by directly targeting metadherin to regulate the AKT and β-catenin signalling pathways.
MicroRNA-433 inhibits cervical cancer progression by directly targeting metadherin to regulate the AKT and β-catenin signalling pathways. Oncol Rep. 2017 Dec;38(6):3639-3649 Authors: Liang C, Ding J, Yang Y, Deng L, Li X Abstract Cervical cancer is one of the most common female malignancies worldwide. Emerging data have shown that microRNAs (miRNAs) play significant roles in various human cancers, including cervical cancer. Aberrantly expressed miRNAs in cervical cancer contribute to tumour occurrence and development as either tumour suppressors or promoters. Research suggests that miRNA-433 (miR-...
Source: Oncology Reports - November 15, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in  vitro through activation of the Hedgehog pathway.
CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway. Oncol Rep. 2017 Nov 02;: Authors: Zhuang H, Cao G, Kou C, Liu T Abstract Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocellular carcinoma (HCC) invasion and its molecular m...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The long non-coding RNA ENST00000547547 reduces 5-fluorouracil resistance of colorectal cancer cells via competitive binding to microRNA-31.
Authors: Li J, Li X, Cen C, Ai X, Lin C, Hu G Abstract Colorectal cancer (CRC) is one of the most common cancers and the third leading cause of cancer-related deaths due to its rapid progression and poor prognosis. 5-Fluorouracil (5-FU)-based chemotherapies are the standard treatment for locally advanced CRC. However, a considerable percentage of CRCs have inherent or acquired 5-FU resistance, which critically impedes clinical outcomes. In the present study, we reported that the expression level ENST00000547547 was downregulated in 5-FU-resistant CRC cells in comparison with the parental cells, While rising with th...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SPLUNC1 knockout enhances LPS-induced lung injury by increasing recruitment of CD11b+Gr-1+ cells to the spleen of mice.
Authors: Zhang H, Li X, Liao S, Wang H, Chen P, Zhu G, Luo Y, Li G, Zhou Y Abstract Short palate, lung and nasal epithelium clone 1 (SPLUNC1) is a tissue-specific gene of nasopharyngeal tissue, and has been recognized as a potential tumor-suppressor gene in nasopharyngeal carcinoma. As a secreted protein, SPLUNC1 plays an important role in innate immunity including antimicrobial and host defense. However, the related immune cells which are regulated by SPLUNC1 remain elusive. In the present study, an acute lung injury (ALI) mouse model was established by administration of lipopolysaccharide (LPS) intraperitone...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells.
Authors: Liu W, Liu X, Wang L, Zhu B, Zhang C, Jia W, Zhu H, Liu X, Zhong M, Xie D, Liu Y, Li S, Shi J, Lin J, Xia X, Jiang X, Ren C Abstract Phospholipase C (PLC) is a pivotal enzyme in the phosphoinositide pathway that promotes the second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), to participate in eukaryotic signal transduction. Several PLC isozymes are associated with cancer, such as PLC-β1, PLC-δ1, PLC-ε and PLC-γ1. However, the role of PLC-δ3 (PLCD3) in nasopharyngeal carcinoma (NPC) has not been investigated to date. In our previous study, we ...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma.
Authors: Olbromski M, Rzechonek A, Grzegrzolka J, Glatzel-Plucinska N, Chachaj A, Werynska B, Podhorska-Okolow M, Dziegiel P Abstract The molecular pathogenesis of the development of non-small cell lung carcinomas (NSCLCs) is extremely complex. Understanding the molecular basis of the development of this malignant tumor may enable the use of targeted therapy, which may result in a better treatment outome for these patients. Adenocarcinoma (AC) is the most common NSCLC subtype, equally common among smokers and non-smokers, and its pathogenesis remains unknown. The SOX18 protein is an important protein that plays a r...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of leptin on leptin receptor isoform expression and proliferative activity in human normal prostate and prostate cancer cell lines.
Authors: Szyszka M, Tyczewska M, Milecka P, Jopek K, Celichowski P, Malendowicz LK, Rucinski M Abstract Results of studies on the expression of leptin and its receptors in the human prostate gland and human prostate cell lines are contradictory. Regarding this, we carefully reinvestigated this issue using human normal prostate (PrEC, PrSC, PrSMC) and prostate cancer (DU145, LNCaP, PC3) cell lines. Expression of leptin receptor isoforms was assessed by qPCR while the effects of leptin on cell proliferative activity was determined by real-time cell analyzer (RTCA). Expression of the leptin receptor variant 1 was...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Crosstalk between p38  MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-α-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells.
Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-α-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells. Oncol Rep. 2017 Nov 02;: Authors: Wang Y, Xia C, Lun Z, Lv Y, Chen W, Li T Abstract Photodynamic therapy (PDT) is considered to be an advancing antitumor technology. PDT using hydrophilic/lipophilic tetra‑α-(4-carboxyphenoxy) phthalocyanine zinc (TαPcZn-PDT) has exhibited antitumor activity in Bel-7402 hepatocellular cancer cells. However, the manner in which p38 MAPK and caspase-9 are involved in t...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co ‑cultures of human endothelial and breast cancer cells.
Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells. Oncol Rep. 2017 Nov 02;: Authors: González-González A, González A, Alonso-González C, Menéndez-Menéndez J, Martínez-Campa C, Cos S Abstract Melatonin exerts oncostatic activity in breast cancer through antiangiogenic actions. There, the aim of the present study was to ascertain whether melatonin modulates, in a coordinated action, angiopoietin-1 (ANG-1), ANG-2, their cognate Tie2 receptor and VEGF i...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-326 inhibits melanoma progression by targeting KRAS and suppressing the AKT and ERK signalling pathways.
Authors: Kang K, Zhang J, Zhang X, Chen Z Abstract Melanoma is the seventh most common malignancy in females and the fifth most common cancer in males worldwide. An increasing number of studies have reported that microRNA (miRNA) dysregulation is frequently observed in various types of human cancers, including melanoma. Abnormally expressed miRNAs play an important role in melanoma formation and progression by serving as potential biomarkers and therapeutic targets. Recently, miRNA-326 (miR-326) has been reported to be differentially expressed in various types of tissues and play important roles in tumourigenesis a...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

IMP3 overexpression occurs in various important cancer types and is linked to aggressive tumor features: A tissue microarray study on 8,877 human cancers and normal tissues.
Authors: Burdelski C, Jakani-Karimi N, Jacobsen F, Möller-Koop C, Minner S, Simon R, Sauter G, Steurer S, Clauditz TS, Wilczak W Abstract IMP3 is an RNA binding protein required for ribosomal RNA processing, which has been suggested to be a prognostic marker in a large variety of human types of cancer. However, available data on the prevalence of IMP3 expression are largely discrepant. To systematically investigate the epidemiology and clinical relevance of IMP3 expression in human cancers we employed a two-step tissue microarrays (TMAs) approach. First, a normal tissue TMA and a multi-tumor TMA were analyzed ...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The screening and analysis of protein signatures and signaling associated with chemoresistance based on Protein Pathway Array technology in gastric cancer.
In conclusion, the predictive model established by PPA may be an effective detection system for predicting the chemosensitivity of gastric cancer patients after D2 gastrectomy. PMID: 29115543 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Influence of the Twist gene on the invasion and metastasis of colon cancer.
Authors: Wang D, Rai B, Qi F, Liu T, Wang J, Wang X, Ma B Abstract The present study investigated the role of the Twist gene in epithelial-mesenchymal transition (EMT) and its effects on the invasion and metastasis of malignant tumors. In vitro, we transfected SW480, HCT116 and HT29 cells with recombinant plasmids, pTracer-CMV/BSD-Twist and pGenesil1.2-Twist-shRNA, to influence expression of Twist. The transfection efficacy of the plasmids in the cell lines was confirmed by flow cytometry. The relative mRNA and protein expression levels of Twist, E-cadherin and vimentin in the transfected cells were detected b...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer.
In conclusion, the present study indicated that frankincense, pine needle and geranium essential oils were involved in the progression of BC cells possibly through the AMPK/mTOR pathway. PMID: 29115548 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of microRNA-95-3p suppresses cell growth of osteosarcoma via CDKN1A/p21 expression.
Authors: Zhao X, Yang Y, Xu J, Luo Y, Xin Y, Wang Y Abstract The purpose of the present study was to examine the function of microRNA-95-3p on cell growth of osteosarcoma and to investigate its mechanism. Compared to healthy controls, the serum expression of microRNA-95-3p was effectively upregulated in patients with osteosarcoma. MicroRNA-95-3p expression in patients with osteosarcoma had significant association with clinical stage. Downregulation of microRNA-95-3p expression suppressed cell growth, induced apoptosis, increased caspase-3 and caspase-9 activities and Bax/Bcl-2 protein expression in osteosarcoma cel...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

P2Y2 receptor promotes the migration and invasion of breast cancer cells via EMT-related genes Snail and E-cadherin.
Authors: Qiu Y, Liu Y, Li WH, Zhang HQ, Tian XX, Fang WG Abstract Adenosine 5'-triphosphate (ATP) is one of the most abundant biochemical constituents within the tumor microenvironment and is postulated to play critical roles in the progression of a number of types of tumors via interaction with the P2Y2 receptor. In the present study, we demonstrated that the P2Y2 receptor was highly expressed in MCF7 and Hs578T breast cancer cells. Downregulation of the P2Y2 receptor by small interfering RNA (siRNA) significantly attenuated ATP- or UTP-driven migration and invasion of the breast cancer cells as well as expre...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-615-5p targets insulin-like growth factor 2 and exerts tumor-suppressing functions in human esophageal squamous cell carcinoma.
Authors: Yang B, Xie R, Wu SN, Gao CC, Yang XZ, Zhou JF Abstract To investigate the expression pattern, clinical significance and functional roles of microRNA (miR)-615-5p in human esophageal squamous cell carcinoma (ESCC), , quantitative real-time PCR was performed to detect expression levels of miR‑615‑5p in ESCC tissues and cell lines. Associations between miR‑615‑5p expression and various clinicopathological features of ESCC patients were also statistically evaluated. The candidate targets of miR‑615‑5p were identified by integrating bioinformatics miRNA target prediction, western blot analysis...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target.
This study evaluated the role of the HGF/c-Met signaling pathway in the progression of human OSCC. We found that the expression of c-Met was significantly increased in human OSCC tissues than in normal mucosa adjacent to the tumor (P
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hypoxia induces differential expression patterns of osteopontin and CD44 in colorectal carcinoma.
Authors: Wohlleben G, Hauff K, Gasser M, Waaga-Gasser AM, Grimmig T, Flentje M, Polat B Abstract The plasma protein osteopontin (OPN) is considered to be a tumor biomarker, where elevated plasma levels are associated with poor prognosis. Additionally, OPN is expressed in the presence of tumor hypoxia, which is an adverse prognostic factor in radiation oncology. One of its receptors, the proposed tumor stem cell marker CD44, is also associated with aggressive tumors, shown for example in colon cancer. The expression of CD44 and its splice variants (particularly CD44v6) can be upregulated by OPN itself. In the presen...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fungal mannosylation enhances human papillomavirus 16 E7 therapeutic immunity against TC-1 tumors.
Authors: Wang Z, Wei C, Zhang Y, Wang W, Zhou Z, Xiao G Abstract Cervical cancer, resulting from infection with human papillomavirus (HPV)16, remains the fourth most common cancer in women worldwide. Recently, three prophylactic HPV vaccines targeting high-risk HPVs (particularly HPV16 and HPV18) have been implemented to protect younger women. However, individuals with pre-existing infections have no benefit from prophylactic vaccines. Thus, there is an urgent need to develop therapeutic vaccines. HPV16 E7 has been widely utilized as a target for immune therapy of HPV16-associated lesions or cancers, reflecting the...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2.
Authors: Lang B, Zhao S Abstract Esophageal cancer is a common tumor for which morbidity and mortality are high worldwide. We aimed to study alterations in miR-486 expression in esophageal cancers, and the effect miR-486 on esophageal cancer cell function and behavior. We collected esophageal cancer tissues/corresponding normal tissues from 20 patients and utilized three esophageal cancer cell lines and normal esophageal epithelial cells, and the expression of miR-486, CDK4 and BCAS2 was detected by qRT-PCR. Western blotting was used to detect the expression of CDK4 and BCAS2 protein. Then, we overexpressed miR-486...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Glioma stem cells and their non-stem differentiated glioma cells exhibit differences in mitochondrial structure and function.
Authors: Kim EJ, Jin X, Kim OR, Ham SW, Park SH, Kim H Abstract Although mitochondria play an important role in cell survival, their biological significance in differentiated and undifferentiated cells is not well known. In the present study, we compared the differences in the structure and function of mitochondria between undifferentiated cancer stem cells and differentiated cancer cells. Glioma stem cells (GSCs), when grown under serum culture conditions, demonstrated a decrease in stem cell marker expression and tumor sphere forming ability, while showing an increase in differentiated cell markers. Transmission ...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research