[Retracted] Hypoxia ‑induced mitochondrial translocation of DNM1L increases mitochondrial fission and triggers mPTP opening in HCC cells via activation of HK2
Oncol Rep. 2021 Jun;45(6):108. doi: 10.3892/or.2021.8059. Epub 2021 Apr 28.ABSTRACTSubsequently to the publication of the above paper, the authors have retrospectively realized that they used the human normal liver cell, line L‑02, for the experiments reported in this study instead of the intended hepatocellular cell line, Huh‑7. Consequently, the results and conclusions reported in this article must be considered to lack reliability. Therefore, the authors have requested that the article be retracted from the publication. The authors apologize to the Editor and to the readership for any inconvenience caused. [the orig...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Min Cai Ping He Dian-Liang Fang Source Type: research

CD244 < sup > + < /sup > polymorphonuclear myeloid ‑derived suppressor cells reflect the status of peritoneal dissemination in a colon cancer mouse model
Oncol Rep. 2021 Jun;45(6):106. doi: 10.3892/or.2021.8057. Epub 2021 Apr 28.ABSTRACTDespite the recent development of chemotherapeutic agents, the prognosis of colorectal cancer (CRC) patients with peritoneal dissemination (PD) remains poor. The tumor immune microenvironment (TIME) has drawn attention as a key contributing factor of tumor progression. Of TIME components, myeloid‑derived suppressor cells (MDSCs) are considered to play a responsible role in the immunosuppressive characteristics of the TIME. MDSCs are classified into two major subsets: Monocytic MDSCs (M‑MDSCs) and polymorphonuclear MDSCs (PMN‑MDSCs). Th...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Yutaka Sugita Kimihiro Yamashita Mitsugu Fujita Masafumi Saito Kota Yamada Kyosuke Agawa Akihiro Watanabe Eiji Fukuoka Hiroshi Hasegawa Shingo Kanaji Taro Oshikiri Takeru Matsuda Tetsu Nakamura Satoshi Suzuki Yoshihiro Kakeji Source Type: research

Schisandrin B inhibits epithelial ‑mesenchymal transition and stemness of large‑cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF‑κB and p38 MAPK signaling pathways
In conclusion, the present study demonstrated that SchB exerted inhibitory effects on large‑cell lung cancer cells via targeting the NF‑κB and p38 MAPK signaling pathways, suggesting that SchB may act as a potential therapeutic drug for large‑cell lung cancer.PMID:33907830 | DOI:10.3892/or.2021.8066 (Source: Oncology Reports)
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Shuping Li Hong Wang Ruidong Ma Li Wang Source Type: research

[Retracted] Bergamottin isolated from < em > Citrus bergamia < /em > exerts < em > in vitro < /em > and < em > in vivo < /em > antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion
Oncol Rep. 2021 Jun;45(6):107. doi: 10.3892/or.2021.8058. Epub 2021 Apr 28.ABSTRACTFollowing the publication of the above paper, a concerned reader drew to the Editor's attention that a number of figures (specifically, Figs. 6, 8, 9, 10 and 12) contained apparent anomalies, including repeated patternings of data within the same figure panels. After having conducted an independent investigation in the Editorial Office, the Editor of Oncology Reports has determined that this paper should be retracted from the Journal on account of a lack of confidence concerning the originality and the authenticity of the data. The authors w...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Hui-Juan Wu Hong-Bo Wu Yan-Qiu Zhao Li-Juan Chen Hong-Zhi Zou Source Type: research

Galectin ‑9 suppresses the tumor growth of colon cancer < em > in  vitro < /em > and < em > in  vivo < /em >
In conclusion, Gal‑9 suppresses the cell proliferation of human colon cancer by inducing apoptosis, and these findings suggest that Gal‑9 can be a potential therapeutic target in the treatment of colon cancer.PMID:33907832 | PMC:PMC8072828 | DOI:10.3892/or.2021.8056 (Source: Oncology Reports)
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Asahiro Morishita Kei Nomura Joji Tani Koji Fujita Hisakazu Iwama Kei Takuma Mai Nakahara Tomoko Tadokoro Kyoko Oura Taiga Chiyo Shintaro Fujihara Toshiro Niki Mitsuomi Hirashima Akira Nishiyama Takashi Himoto Tsutomu Masaki Source Type: research

Golgi phosphoprotein  3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome
Oncol Rep. 2021 Jun;45(6):113. doi: 10.3892/or.2021.8064. Epub 2021 Apr 28.ABSTRACTGolgi phosphoprotein 3 (GOLPH3) has been demonstrated to promote tumor progression in various gastrointestinal malignancies. However, its effects in gallbladder carcinoma (GBC) remain unknown. In the present study, the expression levels of GOLPH3 and nucleotide‑binding domain leucine‑rich repeat and pyrin domain containing receptor 3 (NLRP3) in human GBC tissues were detected by immunohistochemistry, and the clinical data and survival of these patients were analyzed. Next, whether GOLPH3 could affect tumor proliferation via regulation of...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Zhencheng Zhu Qingzhou Zhu Dongping Cai Liang Chen Weixuan Xie Yang Bai Kunlun Luo Source Type: research

Role of SIRT1/AMPK signaling in the proliferation, migration and invasion of renal cell carcinoma cells
Oncol Rep. 2021 Jun;45(6):109. doi: 10.3892/or.2021.8060. Epub 2021 Apr 28.ABSTRACTRenal cell carcinoma (RCC) is a lethal urologic tumor commonly seen in men that best responds to partial nephrectomy. An enhanced understanding of the molecular pathogenesis of RCC can broaden treatment options and tumor prevention strategies. Sirtuin 1 (SIRT1) is a NAD+‑dependent deacetylase that regulates several bioactive substances, and the present study aimed to identify the role of SIRT1/AMP‑activated protein kinase (AMPK) signaling in RCC progression. SIRT1 expression was detected in 100 patients with RCC using tissue microarray i...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Xin Wang Youlu Lu Zhouting Tuo Huan Zhou Ying Zhang Zhangjun Cao Longfei Peng Dexin Yu Liangkuan Bi Source Type: research

AB4 inhibits Notch signaling and promotes cancer cell apoptosis in liver cancer
Oncol Rep. 2021 Jun;45(6):112. doi: 10.3892/or.2021.8063. Epub 2021 Apr 28.ABSTRACTThe etiology for liver cancer has been clearly defined. Unfortunately, therapeutic approaches for liver cancer are rather limited, and liver cancer is insensitive to chemotherapy and radiotherapy. Traditional Chinese medicine (TCM) has become a promising strategy for cancer treatment as TCM elicits broad spectrum anticancer activity. In the present study, we evaluated the anticancer efficacy of AB4, an extract from the medical herb Pulsatilla chinensis (Bunge) Regel, in liver cancer in vitro and in vivo. We found that AB4 readily dose‑ and...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Zhuo Xiang Qing Miao Jin Zhang Guoxin Liu Shuyi Xue Xu Liu Zhe Zhang Lixia Shen Bangguo Liu Yu Zhou Ting Miao Yang Liu Source Type: research

EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in non ‑small cell lung cancer cells
Oncol Rep. 2021 Jun;45(6):102. doi: 10.3892/or.2021.8053. Epub 2021 Apr 28.ABSTRACTOverexpression of ETS‑homologous factor (EHF) in non‑small cell lung cancer (NSCLC) is associated with poor patient prognosis. To explore the mechanism of the effect of EHF in NSCLC, EHF expression was examined in NSCLC and its role in cell proliferation, invasion, cell cycle, and apoptosis of NSCLC cells was evaluated by overexpressing EHF and/or knocking down EHF expression in NSCLC cells in vitro and in cancer cell grafted mice in vivo. The results revealed that the knockdown of EHF expression in NSCLC with siRNA significantly inhibit...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Lei Gao Tian Yang Shuo Zhang Yiqian Liang Puyu Shi Hui Ren Peng Hou Mingwei Chen Source Type: research

RHPN1 ‑AS1 promotes ovarian carcinogenesis by sponging miR‑485‑5p and releasing TPX2 mRNA
Oncol Rep. 2021 Jun;45(6):111. doi: 10.3892/or.2021.8062. Epub 2021 Apr 28.ABSTRACTLong non‑coding RNAs (lncRNAs) play a crucial role in cancer development. However, researchers have yet to identify the underlying association between lncRNAs and ovarian cancer (OC). The aim of the present study was to examine the effect of lncRNA RHPN1‑AS1 (RHPN1‑AS1) on OC cells and tissues. Reverse transcriptase‑quantitative PCR (RT‑qPCR) was utilized to quantify RHPN1‑AS1, miR‑485‑5p, and TPX2 mRNA expression in samples with OC. Luciferase‑reporter assay, RNA immunoprecipitation (RIP) assay, and RNA pull‑down assay w...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Shoubin Cui Cui Li Source Type: research

LOXL1 ‑AS1 promotes thymoma and thymic carcinoma progression by regulating miR‑525‑5p‑ < em > HSPA9 < /em >
In conclusion, LOXL1‑AS1 and HSPA9 are highly expressed in thymoma and thymic carcinoma; miR‑525‑5p is expressed at low levels in thymoma and thymic carcinoma; and downregulation of miR‑525‑5p is associated with poor prognosis. In summary, this study demonstrates that LOXL1‑AS1 acts as a sponge that targets miR‑525‑5p to promote HSPA9 expression, thereby promoting the growth and invasion and inhibiting apoptosis of thymoma and thymic carcinoma cells.PMID:33907842 | DOI:10.3892/or.2021.8068 (Source: Oncology Reports)
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Jin Wang Haihua Huang Xiaomiao Zhang Haitao Ma Source Type: research

Accuracy of MRI for diagnosing pelvic and para ‑aortic lymph node metastasis in cervical cancer
Oncol Rep. 2021 Jun;45(6):100. doi: 10.3892/or.2021.8051. Epub 2021 Apr 28.ABSTRACTThe current study aimed to evaluate the accuracy of diffusion‑weighted imaging and morphological aspects at 3 Tesla (T) and 1.5T MRI for diagnosing metastatic lymph nodes (LN) in cervical cancer. A retrospective study was conducted at the Barretos Cancer Hospital. A total of 45 patients with cervical cancer who underwent MRI examination and pelvic and/or para‑aortic lymphadenectomy as part of surgical procedure were included. Data regarding LN images included size (short‑axis diameters), morphology (usual, rounded or amorphous), appear...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Tamiris Dezen Rodrigo Ribeiro Rossini Marcelo Dimas Spadin Carlos Eduardo Mattos Da Cunha Andrade Ronaldo Schimidt Marcelo A Vieira Marcos A Lima Dioc ésio Alves Pinto De Andrade Ricardo Dos Reis Source Type: research

Vanillin downregulates NNMT and attenuates NNMT ‑related resistance to 5‑fluorouracil via ROS‑induced cell apoptosis in colorectal cancer cells
Oncol Rep. 2021 Jun;45(6):110. doi: 10.3892/or.2021.8061. Epub 2021 Apr 28.ABSTRACTChemoresistance is the main cause of poor prognosis in colorectal cancer (CRC). Nicotinamide N‑methyltransferase (NNMT) is a metabolic enzyme that is upregulated in various tumor types. It has been reported that NNMT inhibits apoptosis and enhances resistance to 5‑fluorouracil (5‑Fu) via inhibition of the apoptosis signal regulating kinase 1 (ASK1)‑p38 MAPK pathway in CRC cells. A natural product library was screened, and it was found that vanillin, also known as 4‑hydroxy‑3‑methoxybenzaldehyde, a plant secondary metabolite fou...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Guoli Li Beibei Kong Qingchao Tong Yejia Li Lifen Chen Jin Zeng Haitao Yu Xinyou Xie Jun Zhang Source Type: research

[Corrigendum] FNDC3B promotes epithelial ‑mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment
Oncol Rep. 2021 Jun;45(6):116. doi: 10.3892/or.2021.8067. Epub 2021 Apr 28.ABSTRACTAfter the publication of the article, and also the publication of a Corrigendum (see doi: 10.3892/or.2020.7744), there are further errors in the published paper that the authors wish to correct in a subsequent corrigendum. In the printed version of Fig. 5, the "NC" images were mistakenly presented in the data panels showing the results of the TCA8113 and TSCCA invasion assay experiments. Furthermore, in Fig. 4A and 6A, the β‑actin control bands were erroneously selected for these figures. The corrected versions of Figs. 4, 5...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Zhaoming Zhong Hongxing Zhang Min Hong Chuanzheng Sun Yuanyuan Xu Xiao Chen Change Gao Minjie He Weiqing Liu Jin Liang Source Type: research

< em > In  vitro < /em > induction of mitotic catastrophe as a therapeutic approach for oral cancer using the ethanolic extract of < em > Juniperus squamata < /em >
Oncol Rep. 2021 Jun;45(6):103. doi: 10.3892/or.2021.8054. Epub 2021 Apr 28.ABSTRACTMitotic catastrophe, a cell death mechanism characterized by abnormal mitosis, has been regarded as a therapeutic approach for the development of anti‑cancer drug candidates. The aim of the present study was to investigate the potential effect of the ethanolic extract of Juniperus squamata (EEJS) on the occurrence of mitotic catastrophe in human oral cancer cell lines. The effect of EEJS on the occurrence of mitotic catastrophe was evaluated by measuring cytotoxicity, observing phase‑contrast or transmission electron microscope findings,...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Minjung Jung Dae Jin Han Chi-Hyun Ahn Kyoung-Ok Hong Youn Soo Choi Jun Sung Kim Hye-Jung Yoon Seong Doo Hong Ji-Ae Shin Sung-Dae Cho Source Type: research

[Retracted] < em > In  vitro < /em > and < em > in  vivo < /em > anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial ‑mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration
Oncol Rep. 2021 Jun;45(6):114. doi: 10.3892/or.2021.8065. Epub 2021 Apr 28.ABSTRACTFollowing the publication of the above paper, a concerned reader drew to the Editor's attention that a pair of tumors in Fig. 10 appeared to have been duplicated, although one of the tumors appeared at a larger size in the figure relative to the first one. Furthermore, the flow cytometric plots shown in Fig. 2B in the above paper appeared to be remarkably similar to data presented in a paper published in Phytomedicine [Sui C‑G, Meng F‑D and Jiang Y‑H: Antiproliferative activity of rosamultic acid is associated with induction of apoptos...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Lin Dong Wen-Wei Xu Hong Li Ke-Hong Bi Source Type: research

Mesenchymal stem cells induce tumor stroma formation and epithelial ‑mesenchymal transition through SPARC expression in colorectal cancer
Oncol Rep. 2021 Jun;45(6):104. doi: 10.3892/or.2021.8055. Epub 2021 Apr 28.ABSTRACTTumor‑stroma interactions serve a crucial role in the development of colorectal cancer (CRC), in which secreted protein acidic and rich in cysteine (SPARC) has been implicated. Due to interactions between cancer and stromal cells [mesenchymal stem cells (MSCs)], SPARC gene expression is markedly upregulated in CRC cells. The present study investigated the role of SPARC in CRC development and its potential as a biomarker. Specifically, the present study examined the association between SPARC expression and clinicopathological characteristic...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Toshikatsu Naito Ryo Yuge Yasuhiko Kitadai Hidehiko Takigawa Yukihito Higashi Toshio Kuwai Kazuya Kuraoka Shinji Tanaka Kazuaki Chayama Source Type: research

Knockdown of SASS6 reduces growth of MDA ‑MB‑231 triple‑negative breast cancer cells through arrest of the cell cycle at the G2/M phase
Oncol Rep. 2021 Jun;45(6):101. doi: 10.3892/or.2021.8052. Epub 2021 Apr 28.ABSTRACTSpindle assembly abnormal protein 6 homolog (SASS6) is crucial for centriole duplication; however, the role of SASS6 in the proliferation of cancer cells remains unclear. In the present study, the expression and functional role of SASS6 in triple negative breast cancer (TNBC) was assessed. Immunohistochemical staining was performed using an anti‑SASS6 antibody in TNBC and normal tissues. Lentivirus‑mediated RNA interference was used to knockdown SASS6 in MDA‑MB‑231 TNBC cells. Cell viability was determined using an MTT assay, and cel...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Lili Du Jiexian Jing Yan Wang Xiaoqin Xu Ting Sun Yanchun Shi Weigang Wang Baoguo Tian Cunzhi Han Xianwen Zhao Huibo Chang Source Type: research

[Retracted] Hypoxia ‑induced mitochondrial translocation of DNM1L increases mitochondrial fission and triggers mPTP opening in HCC cells via activation of HK2
Oncol Rep. 2021 Jun;45(6):108. doi: 10.3892/or.2021.8059. Epub 2021 Apr 28.ABSTRACTSubsequently to the publication of the above paper, the authors have retrospectively realized that they used the human normal liver cell, line L‑02, for the experiments reported in this study instead of the intended hepatocellular cell line, Huh‑7. Consequently, the results and conclusions reported in this article must be considered to lack reliability. Therefore, the authors have requested that the article be retracted from the publication. The authors apologize to the Editor and to the readership for any inconvenience caused. [the orig...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Min Cai Ping He Dian-Liang Fang Source Type: research

CD244 < sup > + < /sup > polymorphonuclear myeloid ‑derived suppressor cells reflect the status of peritoneal dissemination in a colon cancer mouse model
Oncol Rep. 2021 Jun;45(6):106. doi: 10.3892/or.2021.8057. Epub 2021 Apr 28.ABSTRACTDespite the recent development of chemotherapeutic agents, the prognosis of colorectal cancer (CRC) patients with peritoneal dissemination (PD) remains poor. The tumor immune microenvironment (TIME) has drawn attention as a key contributing factor of tumor progression. Of TIME components, myeloid‑derived suppressor cells (MDSCs) are considered to play a responsible role in the immunosuppressive characteristics of the TIME. MDSCs are classified into two major subsets: Monocytic MDSCs (M‑MDSCs) and polymorphonuclear MDSCs (PMN‑MDSCs). Th...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Yutaka Sugita Kimihiro Yamashita Mitsugu Fujita Masafumi Saito Kota Yamada Kyosuke Agawa Akihiro Watanabe Eiji Fukuoka Hiroshi Hasegawa Shingo Kanaji Taro Oshikiri Takeru Matsuda Tetsu Nakamura Satoshi Suzuki Yoshihiro Kakeji Source Type: research

Schisandrin B inhibits epithelial ‑mesenchymal transition and stemness of large‑cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF‑κB and p38 MAPK signaling pathways
In conclusion, the present study demonstrated that SchB exerted inhibitory effects on large‑cell lung cancer cells via targeting the NF‑κB and p38 MAPK signaling pathways, suggesting that SchB may act as a potential therapeutic drug for large‑cell lung cancer.PMID:33907830 | DOI:10.3892/or.2021.8066 (Source: Oncology Reports)
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Shuping Li Hong Wang Ruidong Ma Li Wang Source Type: research

[Retracted] Bergamottin isolated from < em > Citrus bergamia < /em > exerts < em > in vitro < /em > and < em > in vivo < /em > antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion
Oncol Rep. 2021 Jun;45(6):107. doi: 10.3892/or.2021.8058. Epub 2021 Apr 28.ABSTRACTFollowing the publication of the above paper, a concerned reader drew to the Editor's attention that a number of figures (specifically, Figs. 6, 8, 9, 10 and 12) contained apparent anomalies, including repeated patternings of data within the same figure panels. After having conducted an independent investigation in the Editorial Office, the Editor of Oncology Reports has determined that this paper should be retracted from the Journal on account of a lack of confidence concerning the originality and the authenticity of the data. The authors w...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Hui-Juan Wu Hong-Bo Wu Yan-Qiu Zhao Li-Juan Chen Hong-Zhi Zou Source Type: research

Galectin ‑9 suppresses the tumor growth of colon cancer < em > in  vitro < /em > and < em > in  vivo < /em >
In conclusion, Gal‑9 suppresses the cell proliferation of human colon cancer by inducing apoptosis, and these findings suggest that Gal‑9 can be a potential therapeutic target in the treatment of colon cancer.PMID:33907832 | PMC:PMC8072828 | DOI:10.3892/or.2021.8056 (Source: Oncology Reports)
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Asahiro Morishita Kei Nomura Joji Tani Koji Fujita Hisakazu Iwama Kei Takuma Mai Nakahara Tomoko Tadokoro Kyoko Oura Taiga Chiyo Shintaro Fujihara Toshiro Niki Mitsuomi Hirashima Akira Nishiyama Takashi Himoto Tsutomu Masaki Source Type: research

Golgi phosphoprotein  3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome
Oncol Rep. 2021 Jun;45(6):113. doi: 10.3892/or.2021.8064. Epub 2021 Apr 28.ABSTRACTGolgi phosphoprotein 3 (GOLPH3) has been demonstrated to promote tumor progression in various gastrointestinal malignancies. However, its effects in gallbladder carcinoma (GBC) remain unknown. In the present study, the expression levels of GOLPH3 and nucleotide‑binding domain leucine‑rich repeat and pyrin domain containing receptor 3 (NLRP3) in human GBC tissues were detected by immunohistochemistry, and the clinical data and survival of these patients were analyzed. Next, whether GOLPH3 could affect tumor proliferation via regulation of...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Zhencheng Zhu Qingzhou Zhu Dongping Cai Liang Chen Weixuan Xie Yang Bai Kunlun Luo Source Type: research

Role of SIRT1/AMPK signaling in the proliferation, migration and invasion of renal cell carcinoma cells
Oncol Rep. 2021 Jun;45(6):109. doi: 10.3892/or.2021.8060. Epub 2021 Apr 28.ABSTRACTRenal cell carcinoma (RCC) is a lethal urologic tumor commonly seen in men that best responds to partial nephrectomy. An enhanced understanding of the molecular pathogenesis of RCC can broaden treatment options and tumor prevention strategies. Sirtuin 1 (SIRT1) is a NAD+‑dependent deacetylase that regulates several bioactive substances, and the present study aimed to identify the role of SIRT1/AMP‑activated protein kinase (AMPK) signaling in RCC progression. SIRT1 expression was detected in 100 patients with RCC using tissue microarray i...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Xin Wang Youlu Lu Zhouting Tuo Huan Zhou Ying Zhang Zhangjun Cao Longfei Peng Dexin Yu Liangkuan Bi Source Type: research

AB4 inhibits Notch signaling and promotes cancer cell apoptosis in liver cancer
Oncol Rep. 2021 Jun;45(6):112. doi: 10.3892/or.2021.8063. Epub 2021 Apr 28.ABSTRACTThe etiology for liver cancer has been clearly defined. Unfortunately, therapeutic approaches for liver cancer are rather limited, and liver cancer is insensitive to chemotherapy and radiotherapy. Traditional Chinese medicine (TCM) has become a promising strategy for cancer treatment as TCM elicits broad spectrum anticancer activity. In the present study, we evaluated the anticancer efficacy of AB4, an extract from the medical herb Pulsatilla chinensis (Bunge) Regel, in liver cancer in vitro and in vivo. We found that AB4 readily dose‑ and...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Zhuo Xiang Qing Miao Jin Zhang Guoxin Liu Shuyi Xue Xu Liu Zhe Zhang Lixia Shen Bangguo Liu Yu Zhou Ting Miao Yang Liu Source Type: research

EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in non ‑small cell lung cancer cells
Oncol Rep. 2021 Jun;45(6):102. doi: 10.3892/or.2021.8053. Epub 2021 Apr 28.ABSTRACTOverexpression of ETS‑homologous factor (EHF) in non‑small cell lung cancer (NSCLC) is associated with poor patient prognosis. To explore the mechanism of the effect of EHF in NSCLC, EHF expression was examined in NSCLC and its role in cell proliferation, invasion, cell cycle, and apoptosis of NSCLC cells was evaluated by overexpressing EHF and/or knocking down EHF expression in NSCLC cells in vitro and in cancer cell grafted mice in vivo. The results revealed that the knockdown of EHF expression in NSCLC with siRNA significantly inhibit...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Lei Gao Tian Yang Shuo Zhang Yiqian Liang Puyu Shi Hui Ren Peng Hou Mingwei Chen Source Type: research

RHPN1 ‑AS1 promotes ovarian carcinogenesis by sponging miR‑485‑5p and releasing TPX2 mRNA
Oncol Rep. 2021 Jun;45(6):111. doi: 10.3892/or.2021.8062. Epub 2021 Apr 28.ABSTRACTLong non‑coding RNAs (lncRNAs) play a crucial role in cancer development. However, researchers have yet to identify the underlying association between lncRNAs and ovarian cancer (OC). The aim of the present study was to examine the effect of lncRNA RHPN1‑AS1 (RHPN1‑AS1) on OC cells and tissues. Reverse transcriptase‑quantitative PCR (RT‑qPCR) was utilized to quantify RHPN1‑AS1, miR‑485‑5p, and TPX2 mRNA expression in samples with OC. Luciferase‑reporter assay, RNA immunoprecipitation (RIP) assay, and RNA pull‑down assay w...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Shoubin Cui Cui Li Source Type: research

LOXL1 ‑AS1 promotes thymoma and thymic carcinoma progression by regulating miR‑525‑5p‑ < em > HSPA9 < /em >
In conclusion, LOXL1‑AS1 and HSPA9 are highly expressed in thymoma and thymic carcinoma; miR‑525‑5p is expressed at low levels in thymoma and thymic carcinoma; and downregulation of miR‑525‑5p is associated with poor prognosis. In summary, this study demonstrates that LOXL1‑AS1 acts as a sponge that targets miR‑525‑5p to promote HSPA9 expression, thereby promoting the growth and invasion and inhibiting apoptosis of thymoma and thymic carcinoma cells.PMID:33907842 | DOI:10.3892/or.2021.8068 (Source: Oncology Reports)
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Jin Wang Haihua Huang Xiaomiao Zhang Haitao Ma Source Type: research

Accuracy of MRI for diagnosing pelvic and para ‑aortic lymph node metastasis in cervical cancer
Oncol Rep. 2021 Jun;45(6):100. doi: 10.3892/or.2021.8051. Epub 2021 Apr 28.ABSTRACTThe current study aimed to evaluate the accuracy of diffusion‑weighted imaging and morphological aspects at 3 Tesla (T) and 1.5T MRI for diagnosing metastatic lymph nodes (LN) in cervical cancer. A retrospective study was conducted at the Barretos Cancer Hospital. A total of 45 patients with cervical cancer who underwent MRI examination and pelvic and/or para‑aortic lymphadenectomy as part of surgical procedure were included. Data regarding LN images included size (short‑axis diameters), morphology (usual, rounded or amorphous), appear...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Tamiris Dezen Rodrigo Ribeiro Rossini Marcelo Dimas Spadin Carlos Eduardo Mattos Da Cunha Andrade Ronaldo Schimidt Marcelo A Vieira Marcos A Lima Dioc ésio Alves Pinto De Andrade Ricardo Dos Reis Source Type: research

Vanillin downregulates NNMT and attenuates NNMT ‑related resistance to 5‑fluorouracil via ROS‑induced cell apoptosis in colorectal cancer cells
Oncol Rep. 2021 Jun;45(6):110. doi: 10.3892/or.2021.8061. Epub 2021 Apr 28.ABSTRACTChemoresistance is the main cause of poor prognosis in colorectal cancer (CRC). Nicotinamide N‑methyltransferase (NNMT) is a metabolic enzyme that is upregulated in various tumor types. It has been reported that NNMT inhibits apoptosis and enhances resistance to 5‑fluorouracil (5‑Fu) via inhibition of the apoptosis signal regulating kinase 1 (ASK1)‑p38 MAPK pathway in CRC cells. A natural product library was screened, and it was found that vanillin, also known as 4‑hydroxy‑3‑methoxybenzaldehyde, a plant secondary metabolite fou...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Guoli Li Beibei Kong Qingchao Tong Yejia Li Lifen Chen Jin Zeng Haitao Yu Xinyou Xie Jun Zhang Source Type: research

[Corrigendum] FNDC3B promotes epithelial ‑mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment
Oncol Rep. 2021 Jun;45(6):116. doi: 10.3892/or.2021.8067. Epub 2021 Apr 28.ABSTRACTAfter the publication of the article, and also the publication of a Corrigendum (see doi: 10.3892/or.2020.7744), there are further errors in the published paper that the authors wish to correct in a subsequent corrigendum. In the printed version of Fig. 5, the "NC" images were mistakenly presented in the data panels showing the results of the TCA8113 and TSCCA invasion assay experiments. Furthermore, in Fig. 4A and 6A, the β‑actin control bands were erroneously selected for these figures. The corrected versions of Figs. 4, 5...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Zhaoming Zhong Hongxing Zhang Min Hong Chuanzheng Sun Yuanyuan Xu Xiao Chen Change Gao Minjie He Weiqing Liu Jin Liang Source Type: research

< em > In  vitro < /em > induction of mitotic catastrophe as a therapeutic approach for oral cancer using the ethanolic extract of < em > Juniperus squamata < /em >
Oncol Rep. 2021 Jun;45(6):103. doi: 10.3892/or.2021.8054. Epub 2021 Apr 28.ABSTRACTMitotic catastrophe, a cell death mechanism characterized by abnormal mitosis, has been regarded as a therapeutic approach for the development of anti‑cancer drug candidates. The aim of the present study was to investigate the potential effect of the ethanolic extract of Juniperus squamata (EEJS) on the occurrence of mitotic catastrophe in human oral cancer cell lines. The effect of EEJS on the occurrence of mitotic catastrophe was evaluated by measuring cytotoxicity, observing phase‑contrast or transmission electron microscope findings,...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Minjung Jung Dae Jin Han Chi-Hyun Ahn Kyoung-Ok Hong Youn Soo Choi Jun Sung Kim Hye-Jung Yoon Seong Doo Hong Ji-Ae Shin Sung-Dae Cho Source Type: research

[Retracted] < em > In  vitro < /em > and < em > in  vivo < /em > anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial ‑mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration
Oncol Rep. 2021 Jun;45(6):114. doi: 10.3892/or.2021.8065. Epub 2021 Apr 28.ABSTRACTFollowing the publication of the above paper, a concerned reader drew to the Editor's attention that a pair of tumors in Fig. 10 appeared to have been duplicated, although one of the tumors appeared at a larger size in the figure relative to the first one. Furthermore, the flow cytometric plots shown in Fig. 2B in the above paper appeared to be remarkably similar to data presented in a paper published in Phytomedicine [Sui C‑G, Meng F‑D and Jiang Y‑H: Antiproliferative activity of rosamultic acid is associated with induction of apoptos...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Lin Dong Wen-Wei Xu Hong Li Ke-Hong Bi Source Type: research

Mesenchymal stem cells induce tumor stroma formation and epithelial ‑mesenchymal transition through SPARC expression in colorectal cancer
Oncol Rep. 2021 Jun;45(6):104. doi: 10.3892/or.2021.8055. Epub 2021 Apr 28.ABSTRACTTumor‑stroma interactions serve a crucial role in the development of colorectal cancer (CRC), in which secreted protein acidic and rich in cysteine (SPARC) has been implicated. Due to interactions between cancer and stromal cells [mesenchymal stem cells (MSCs)], SPARC gene expression is markedly upregulated in CRC cells. The present study investigated the role of SPARC in CRC development and its potential as a biomarker. Specifically, the present study examined the association between SPARC expression and clinicopathological characteristic...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Toshikatsu Naito Ryo Yuge Yasuhiko Kitadai Hidehiko Takigawa Yukihito Higashi Toshio Kuwai Kazuya Kuraoka Shinji Tanaka Kazuaki Chayama Source Type: research

Knockdown of SASS6 reduces growth of MDA ‑MB‑231 triple‑negative breast cancer cells through arrest of the cell cycle at the G2/M phase
Oncol Rep. 2021 Jun;45(6):101. doi: 10.3892/or.2021.8052. Epub 2021 Apr 28.ABSTRACTSpindle assembly abnormal protein 6 homolog (SASS6) is crucial for centriole duplication; however, the role of SASS6 in the proliferation of cancer cells remains unclear. In the present study, the expression and functional role of SASS6 in triple negative breast cancer (TNBC) was assessed. Immunohistochemical staining was performed using an anti‑SASS6 antibody in TNBC and normal tissues. Lentivirus‑mediated RNA interference was used to knockdown SASS6 in MDA‑MB‑231 TNBC cells. Cell viability was determined using an MTT assay, and cel...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Lili Du Jiexian Jing Yan Wang Xiaoqin Xu Ting Sun Yanchun Shi Weigang Wang Baoguo Tian Cunzhi Han Xianwen Zhao Huibo Chang Source Type: research

[Retracted] Hypoxia ‑induced mitochondrial translocation of DNM1L increases mitochondrial fission and triggers mPTP opening in HCC cells via activation of HK2
Oncol Rep. 2021 Jun;45(6):108. doi: 10.3892/or.2021.8059. Epub 2021 Apr 28.ABSTRACTSubsequently to the publication of the above paper, the authors have retrospectively realized that they used the human normal liver cell, line L‑02, for the experiments reported in this study instead of the intended hepatocellular cell line, Huh‑7. Consequently, the results and conclusions reported in this article must be considered to lack reliability. Therefore, the authors have requested that the article be retracted from the publication. The authors apologize to the Editor and to the readership for any inconvenience caused. [the orig...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Min Cai Ping He Dian-Liang Fang Source Type: research

CD244 < sup > + < /sup > polymorphonuclear myeloid ‑derived suppressor cells reflect the status of peritoneal dissemination in a colon cancer mouse model
Oncol Rep. 2021 Jun;45(6):106. doi: 10.3892/or.2021.8057. Epub 2021 Apr 28.ABSTRACTDespite the recent development of chemotherapeutic agents, the prognosis of colorectal cancer (CRC) patients with peritoneal dissemination (PD) remains poor. The tumor immune microenvironment (TIME) has drawn attention as a key contributing factor of tumor progression. Of TIME components, myeloid‑derived suppressor cells (MDSCs) are considered to play a responsible role in the immunosuppressive characteristics of the TIME. MDSCs are classified into two major subsets: Monocytic MDSCs (M‑MDSCs) and polymorphonuclear MDSCs (PMN‑MDSCs). Th...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Yutaka Sugita Kimihiro Yamashita Mitsugu Fujita Masafumi Saito Kota Yamada Kyosuke Agawa Akihiro Watanabe Eiji Fukuoka Hiroshi Hasegawa Shingo Kanaji Taro Oshikiri Takeru Matsuda Tetsu Nakamura Satoshi Suzuki Yoshihiro Kakeji Source Type: research

Schisandrin B inhibits epithelial ‑mesenchymal transition and stemness of large‑cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF‑κB and p38 MAPK signaling pathways
In conclusion, the present study demonstrated that SchB exerted inhibitory effects on large‑cell lung cancer cells via targeting the NF‑κB and p38 MAPK signaling pathways, suggesting that SchB may act as a potential therapeutic drug for large‑cell lung cancer.PMID:33907830 | DOI:10.3892/or.2021.8066 (Source: Oncology Reports)
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Shuping Li Hong Wang Ruidong Ma Li Wang Source Type: research

[Retracted] Bergamottin isolated from < em > Citrus bergamia < /em > exerts < em > in vitro < /em > and < em > in vivo < /em > antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion
Oncol Rep. 2021 Jun;45(6):107. doi: 10.3892/or.2021.8058. Epub 2021 Apr 28.ABSTRACTFollowing the publication of the above paper, a concerned reader drew to the Editor's attention that a number of figures (specifically, Figs. 6, 8, 9, 10 and 12) contained apparent anomalies, including repeated patternings of data within the same figure panels. After having conducted an independent investigation in the Editorial Office, the Editor of Oncology Reports has determined that this paper should be retracted from the Journal on account of a lack of confidence concerning the originality and the authenticity of the data. The authors w...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Hui-Juan Wu Hong-Bo Wu Yan-Qiu Zhao Li-Juan Chen Hong-Zhi Zou Source Type: research

Galectin ‑9 suppresses the tumor growth of colon cancer < em > in  vitro < /em > and < em > in  vivo < /em >
In conclusion, Gal‑9 suppresses the cell proliferation of human colon cancer by inducing apoptosis, and these findings suggest that Gal‑9 can be a potential therapeutic target in the treatment of colon cancer.PMID:33907832 | PMC:PMC8072828 | DOI:10.3892/or.2021.8056 (Source: Oncology Reports)
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Asahiro Morishita Kei Nomura Joji Tani Koji Fujita Hisakazu Iwama Kei Takuma Mai Nakahara Tomoko Tadokoro Kyoko Oura Taiga Chiyo Shintaro Fujihara Toshiro Niki Mitsuomi Hirashima Akira Nishiyama Takashi Himoto Tsutomu Masaki Source Type: research

Golgi phosphoprotein  3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome
Oncol Rep. 2021 Jun;45(6):113. doi: 10.3892/or.2021.8064. Epub 2021 Apr 28.ABSTRACTGolgi phosphoprotein 3 (GOLPH3) has been demonstrated to promote tumor progression in various gastrointestinal malignancies. However, its effects in gallbladder carcinoma (GBC) remain unknown. In the present study, the expression levels of GOLPH3 and nucleotide‑binding domain leucine‑rich repeat and pyrin domain containing receptor 3 (NLRP3) in human GBC tissues were detected by immunohistochemistry, and the clinical data and survival of these patients were analyzed. Next, whether GOLPH3 could affect tumor proliferation via regulation of...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Zhencheng Zhu Qingzhou Zhu Dongping Cai Liang Chen Weixuan Xie Yang Bai Kunlun Luo Source Type: research

Role of SIRT1/AMPK signaling in the proliferation, migration and invasion of renal cell carcinoma cells
Oncol Rep. 2021 Jun;45(6):109. doi: 10.3892/or.2021.8060. Epub 2021 Apr 28.ABSTRACTRenal cell carcinoma (RCC) is a lethal urologic tumor commonly seen in men that best responds to partial nephrectomy. An enhanced understanding of the molecular pathogenesis of RCC can broaden treatment options and tumor prevention strategies. Sirtuin 1 (SIRT1) is a NAD+‑dependent deacetylase that regulates several bioactive substances, and the present study aimed to identify the role of SIRT1/AMP‑activated protein kinase (AMPK) signaling in RCC progression. SIRT1 expression was detected in 100 patients with RCC using tissue microarray i...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Xin Wang Youlu Lu Zhouting Tuo Huan Zhou Ying Zhang Zhangjun Cao Longfei Peng Dexin Yu Liangkuan Bi Source Type: research

AB4 inhibits Notch signaling and promotes cancer cell apoptosis in liver cancer
Oncol Rep. 2021 Jun;45(6):112. doi: 10.3892/or.2021.8063. Epub 2021 Apr 28.ABSTRACTThe etiology for liver cancer has been clearly defined. Unfortunately, therapeutic approaches for liver cancer are rather limited, and liver cancer is insensitive to chemotherapy and radiotherapy. Traditional Chinese medicine (TCM) has become a promising strategy for cancer treatment as TCM elicits broad spectrum anticancer activity. In the present study, we evaluated the anticancer efficacy of AB4, an extract from the medical herb Pulsatilla chinensis (Bunge) Regel, in liver cancer in vitro and in vivo. We found that AB4 readily dose‑ and...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Zhuo Xiang Qing Miao Jin Zhang Guoxin Liu Shuyi Xue Xu Liu Zhe Zhang Lixia Shen Bangguo Liu Yu Zhou Ting Miao Yang Liu Source Type: research

EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in non ‑small cell lung cancer cells
Oncol Rep. 2021 Jun;45(6):102. doi: 10.3892/or.2021.8053. Epub 2021 Apr 28.ABSTRACTOverexpression of ETS‑homologous factor (EHF) in non‑small cell lung cancer (NSCLC) is associated with poor patient prognosis. To explore the mechanism of the effect of EHF in NSCLC, EHF expression was examined in NSCLC and its role in cell proliferation, invasion, cell cycle, and apoptosis of NSCLC cells was evaluated by overexpressing EHF and/or knocking down EHF expression in NSCLC cells in vitro and in cancer cell grafted mice in vivo. The results revealed that the knockdown of EHF expression in NSCLC with siRNA significantly inhibit...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Lei Gao Tian Yang Shuo Zhang Yiqian Liang Puyu Shi Hui Ren Peng Hou Mingwei Chen Source Type: research

RHPN1 ‑AS1 promotes ovarian carcinogenesis by sponging miR‑485‑5p and releasing TPX2 mRNA
Oncol Rep. 2021 Jun;45(6):111. doi: 10.3892/or.2021.8062. Epub 2021 Apr 28.ABSTRACTLong non‑coding RNAs (lncRNAs) play a crucial role in cancer development. However, researchers have yet to identify the underlying association between lncRNAs and ovarian cancer (OC). The aim of the present study was to examine the effect of lncRNA RHPN1‑AS1 (RHPN1‑AS1) on OC cells and tissues. Reverse transcriptase‑quantitative PCR (RT‑qPCR) was utilized to quantify RHPN1‑AS1, miR‑485‑5p, and TPX2 mRNA expression in samples with OC. Luciferase‑reporter assay, RNA immunoprecipitation (RIP) assay, and RNA pull‑down assay w...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Shoubin Cui Cui Li Source Type: research

LOXL1 ‑AS1 promotes thymoma and thymic carcinoma progression by regulating miR‑525‑5p‑ < em > HSPA9 < /em >
In conclusion, LOXL1‑AS1 and HSPA9 are highly expressed in thymoma and thymic carcinoma; miR‑525‑5p is expressed at low levels in thymoma and thymic carcinoma; and downregulation of miR‑525‑5p is associated with poor prognosis. In summary, this study demonstrates that LOXL1‑AS1 acts as a sponge that targets miR‑525‑5p to promote HSPA9 expression, thereby promoting the growth and invasion and inhibiting apoptosis of thymoma and thymic carcinoma cells.PMID:33907842 | DOI:10.3892/or.2021.8068 (Source: Oncology Reports)
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Jin Wang Haihua Huang Xiaomiao Zhang Haitao Ma Source Type: research

Accuracy of MRI for diagnosing pelvic and para ‑aortic lymph node metastasis in cervical cancer
Oncol Rep. 2021 Jun;45(6):100. doi: 10.3892/or.2021.8051. Epub 2021 Apr 28.ABSTRACTThe current study aimed to evaluate the accuracy of diffusion‑weighted imaging and morphological aspects at 3 Tesla (T) and 1.5T MRI for diagnosing metastatic lymph nodes (LN) in cervical cancer. A retrospective study was conducted at the Barretos Cancer Hospital. A total of 45 patients with cervical cancer who underwent MRI examination and pelvic and/or para‑aortic lymphadenectomy as part of surgical procedure were included. Data regarding LN images included size (short‑axis diameters), morphology (usual, rounded or amorphous), appear...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Tamiris Dezen Rodrigo Ribeiro Rossini Marcelo Dimas Spadin Carlos Eduardo Mattos Da Cunha Andrade Ronaldo Schimidt Marcelo A Vieira Marcos A Lima Dioc ésio Alves Pinto De Andrade Ricardo Dos Reis Source Type: research

Vanillin downregulates NNMT and attenuates NNMT ‑related resistance to 5‑fluorouracil via ROS‑induced cell apoptosis in colorectal cancer cells
Oncol Rep. 2021 Jun;45(6):110. doi: 10.3892/or.2021.8061. Epub 2021 Apr 28.ABSTRACTChemoresistance is the main cause of poor prognosis in colorectal cancer (CRC). Nicotinamide N‑methyltransferase (NNMT) is a metabolic enzyme that is upregulated in various tumor types. It has been reported that NNMT inhibits apoptosis and enhances resistance to 5‑fluorouracil (5‑Fu) via inhibition of the apoptosis signal regulating kinase 1 (ASK1)‑p38 MAPK pathway in CRC cells. A natural product library was screened, and it was found that vanillin, also known as 4‑hydroxy‑3‑methoxybenzaldehyde, a plant secondary metabolite fou...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Guoli Li Beibei Kong Qingchao Tong Yejia Li Lifen Chen Jin Zeng Haitao Yu Xinyou Xie Jun Zhang Source Type: research

[Corrigendum] FNDC3B promotes epithelial ‑mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment
Oncol Rep. 2021 Jun;45(6):116. doi: 10.3892/or.2021.8067. Epub 2021 Apr 28.ABSTRACTAfter the publication of the article, and also the publication of a Corrigendum (see doi: 10.3892/or.2020.7744), there are further errors in the published paper that the authors wish to correct in a subsequent corrigendum. In the printed version of Fig. 5, the "NC" images were mistakenly presented in the data panels showing the results of the TCA8113 and TSCCA invasion assay experiments. Furthermore, in Fig. 4A and 6A, the β‑actin control bands were erroneously selected for these figures. The corrected versions of Figs. 4, 5...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Zhaoming Zhong Hongxing Zhang Min Hong Chuanzheng Sun Yuanyuan Xu Xiao Chen Change Gao Minjie He Weiqing Liu Jin Liang Source Type: research