Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.
Authors: Gao H, Chen X, Shang Z, Niu Y Abstract Long non-coding RNAs (lncRNAs) make up a significant portion of transcripts that are not translated into proteins and lncRNAs were previously thought to be transcriptional noise. Recently, there has been increased interest in lncRNAs due to their diverse functions in human cancers. At present, lncRNAs are considered to be the main component of the competing endogenous RNA (ceRNA) network due to their regulatory role in protein-coding gene expression by acting as microRNA (miRNA) sponges. However, the function of the lncRNA-mediated ceRNA network in renal cell carcinom...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Timed ‑flat infusion of 5‑fluorouracil with docetaxel and oxaliplatin as first‑line treatment of gastroesophageal adenocarcinoma: A single institution experience with the FD/FOx regimen.
Timed‑flat infusion of 5‑fluorouracil with docetaxel and oxaliplatin as first‑line treatment of gastroesophageal adenocarcinoma: A single institution experience with the FD/FOx regimen. Oncol Rep. 2018 Jun 06;: Authors: Cortellini A, Cannita K, Parisi A, Venditti O, Lanfiuti Baldi P, De Berardis B, Vicentini R, Vicentini V, Verna L, Porzio G, Ficorella C Abstract To date, there is no consensus regarding first‑line chemotherapy for patients with HER2‑negative, locally advanced/metastatic gastric cancer (a/m GC). In the present study we reported a retrospective case‑series of patients treated...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sperm ‑associated antigen 4 (SPAG4) as a new cancer marker interacts with Nesprin3 to regulate cell migration in lung carcinoma.
Sperm‑associated antigen 4 (SPAG4) as a new cancer marker interacts with Nesprin3 to regulate cell migration in lung carcinoma. Oncol Rep. 2018 Jun 04;: Authors: Ji Y, Jiang J, Huang L, Feng W, Zhang Z, Jin L, Xing X Abstract Lung cancer is the most common cause of cancer‑related deaths, and early diagnosis and targeted therapy are extremely important in the treatment of this disease. Sperm‑associated antigen 4 (SPAG4) was recently found to be a novel cancer biomarker. In the present study, the expression of SPAG4 was revealed to be high in lung adenocarcinoma tissues as determined by w...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulated miR ‑20a‑5p expression promotes proliferation and invasion of head and neck squamous cell carcinoma cells by targeting of TNFRSF21.
In conclusion, miR‑20a‑5p functioned as an oncogene in HNSCC by downregulating TNFRSF21 and subsequently, upregulating CCR7 expression. PMID: 29901115 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genistein and AG1024 synergistically increase the radiosensitivity of prostate cancer cells.
Authors: Tang Q, Ma J, Sun J, Yang L, Yang F, Zhang W, Li R, Wang L, Wang Y, Wang H Abstract Radiosensitivity of prostate cancer (PCa) cells promotes the curative treatment for PCa. The present study was designed to investigate the synergistic effect of genistein and AG1024 on the radiosensitivity of PCa cells. The optimal X‑irradiation dose (4 Gy) and genistein concentration (30 µM) were selected by using the CCK‑8 assay. Before X‑irradiation (4 Gy), PC3 and DU145 cells were treated with genistein (30 µM), AG1024 (10 µM) and their combination. All treatments signifi...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Diagnostic value and lymph node metastasis prediction of a custom ‑made panel (thyroline) in thyroid cancer.
In conclusion, the prediction value of NGS was higher than the US‑based Thyroid Imaging Reporting and Data System (TI‑RADS). NGS is valuable for the accurate differentiation of benign and malignant thyroid nodules, and pathological subtypes in FFPE samples. The findings of the present study may pave the way for the application of NGS in analyzing fine‑needle aspiration (FNA) biopsy samples. PMID: 29901149 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Estrogen ‑related receptor γ promotes the migration and metastasis of endometrial cancer cells by targeting S100A4.
Estrogen‑related receptor γ promotes the migration and metastasis of endometrial cancer cells by targeting S100A4. Oncol Rep. 2018 Jun 04;: Authors: Hua T, Wang X, Chi S, Liu Y, Feng D, Zhao Y, Wang H Abstract S100 calcium binding protein A4 (S100A4) is a well‑established tumor metastasis mediator in various malignancies, including endometrial cancer (EC). However, the regulatory mechanism underlying S100A4 expression remains elusive. In the present study, by analyzing public datasets and clinical samples, we found that estrogen‑related receptor γ (ERRγ) was upregulate...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

G ‑protein‑coupled receptor 120 regulates the development and progression of human esophageal cancer.
In conclusion, we observed an increased level of GPR120 in esophageal cancer tissues, which served as a positive regulator of the development and progression of esophageal cancer. Multiple mechanisms including EMT, PI3K and I‑κB pathway, as well as angiogenesis and inflammation‑related cytokines were involved. PMID: 29901155 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Oct4 promotes cancer cell proliferation and migration and leads to poor prognosis associated with the survivin/STAT3 pathway in hepatocellular carcinoma.
Authors: Wang G, Zhou H, Gu Z, Gao Q, Shen G Abstract Octamer‑binding transcription factor 4 (Oct4) has been identified as a novel transcription factor associated with tumorigenesis, acquisition and maintenance of cancer stem cell characteristics and poor prognosis in tumors. However, the role of Oct4 in tumorigenesis and progression of hepatocellular carcinoma (HCC) has not yet been fully elucidated. In our present study, we observed that the Oct4 expression level was upregulated in HCC specimens as well as in different HCC cell lines. In in vitro experiments, decreased expression of Oct4 by shRNA inhi...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.
In conclusion, Wnt signaling increases DNMT1 expression. DNMT1 contributes to promoter hypermethylation and epigenetic NHERF1 silencing in colon cancer. In addition, we provide novel insight into the mechanisms underlying the regulation of NHERF1 expression and occurrence/progression of colon cancer. PMID: 29901158 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Trop2 is a potential biomarker for the promotion of EMT in human breast cancer.
Authors: Zhao W, Kuai X, Zhou X, Jia L, Wang J, Yang X, Tian Z, Wang X, Lv Q, Wang B, Zhao Y, Huang W Abstract Trop2 is considered to have an important function in tumor metastasis and the promotion of epithelial‑mesenchymal transition (EMT). E‑cadherin is a crucial factor in intercellular adhesion and EMT transformation. In the present study, we detected the expression of Trop2 and E‑cadherin in breast cancer (BC) to better define their prognostic value. The mRNA expression levels of these two genes in 20 cases of fresh BC tissues were detected by quantitative real‑time polymerase chain reaction (qRT...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells.
Authors: Yuan Y, Chiba P, Cai T, Callaghan R, Bai L, Cole SPC, Cai Y Abstract In the present study, a lipid-polymer hybrid drug carrier system was developed to encapsulate psoralen (PSO), a multidrug resistance reversal agent and traditional Chinese medicine. Emphasis was focused the parameters that influence physicochemical characteristics, and then the drug release profile, stability, cytotoxicity and drug resistance reversal effect of the lipid-polymer hybrid nanoparticles (LPNs) were investigated. It was found that various formulation parameters affected NP size, drug loading (DL) and release characteristics. H...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma.
Authors: Huang J, Huang W, Liu M, Zhu J, Jiang D, Xiong Y, Zhen Y, Yang D, Chen Z, Peng L, Yu Z Abstract SETDB1, an H3K9‑specific histone methyltransferase, has been described as a repressed transcription marker which triggers tumorigenesis of many types of human cancer. However, there are few studies elucidating the relationship between SETDB1 and nasopharyngeal carcinoma. In the present study, we confirmed that SETDB1 exhibited higher expression levels in nasopharyngeal carcinoma (NPC) tissues and cell lines, compared to these levels in non‑tumor tissues and a normal human nasopharyngeal epithelial cell line....
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non ‑small lung cancer cells by regulating the YAP pathway.
Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway. Oncol Rep. 2018 Jun 12;: Authors: Jin D, Wu Y, Shao C, Gao Y, Wang D, Guo J Abstract Non‑small cell lung cancer (NSCLC) accounts for>80% of all lung cancer cases, which are the leading cause of cancer‑related mortality worldwide. The clinical efficacy of available therapies for NSCLC is often limited due to the development of resistance to anticancer drugs, particularly to cisplatin (DDP). Norcantharidin (NCTD) is a traditional Chin...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling.
This study aimed to investigate whether the activation of TLR4 signaling by HSP70 could be inhibited by curcumin, thus investigating the possible mechanism of curcumin in the inhibition of liver cancer. Western blotting was used to evaluate the expression of the HSP70 and TLR4 in HepG2 cells and ELISA was used to detect the concentration of HSP70 in cell culture medium. A thermal tolerance HepG2 (HepG2TT) cell model was established to simulate HSP70 accumulation in the microenvironment. A certain concentration of curcumin was co-cultured with HepG2 and HepG2TT cells to observe the changes of HSP70 and TLR4. Our results rev...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells.
Authors: Wei Y, Han T, Wang R, Wei J, Peng K, Lin Q, Shao G Abstract Subsequently to the publication of the article, the authors have realized that the bar chart that accompanied Fig. 4C, indicating the quantification of the western blotting data in this figure part, was published in the absence of either of the axes labels. The authors apologize for this oversight, and a corrected version of Fig. 4, which incorporates the missing labels, is shown opposite. The omission of these axes labels did not have an impact on the overall meaning of the paper. The authors regret that an incomplete version of Fig.&nb...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Alternative splicing variant of RHBDD2 is associated with cell stress response and breast cancer progression.
Authors: Canzoneri R, Rabassa ME, Gurruchaga A, Ferretti V, Palma S, Isla-Larrain M, Croce MV, Lacunza E, Abba MC Abstract RHBDD2 is an intramembrane pseudoprotease member of the Rhomboid superfamily. Our previous studies in breast and colorectal cancer indicate an association between RHBDD2 overexpression and advanced tumor stages. Two alternative transcriptional variants have been described for RHBDD2, which would be encoding for different RHBDD2 protein isoforms. The expression of these RHBDD2 variants/isoforms and its association with breast cancer was the focus of this study. First, expression of RHBDD2 splici...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

γ-tocotrienol inhibits the invasion and migration of human gastric cancer cells through downregulation of cyclooxygenase-2 expression.
γ-tocotrienol inhibits the invasion and migration of human gastric cancer cells through downregulation of cyclooxygenase-2 expression. Oncol Rep. 2018 Jun 14;: Authors: Zhang YH, Ma K, Liu JR, Wang HX, Tian WX, Tu YH, Sun WG Abstract γ-tocotrienol (γ-T3), a tocotrienol isoform belonging to the vitamin E family, has been revealed to exert inhibitory effects on proliferation, migration and invasion in human gastric cancer cells. However, its precise mechanism of action is still unclear and needs to be further tested. Cyclooxygenase-2 (COX-2) is well known for its key role in promot...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of miR-140-5p inhibits lipopolysaccharide-induced human intervertebral disc inflammation and degeneration by downregulating toll-like receptor 4.
In conclusion, the present study may lead to a greater understanding of IVD degeneration and provide new insights into the treatment of this disease. PMID: 29901170 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DKC1 serves as a potential prognostic biomarker for human clear cell renal cell carcinoma and promotes its proliferation, migration and invasion via the NF ‑κB pathway.
We examined DKC1 protein expression levels in tissue microarrays including 307 cases of ccRCC tissues and in 75 pairs of ccRCC and paracancerous tissues with immunohistochemistry. The percentage of DKC1 expression in ccRCC (61.3%) was markedly higher than that in paracancerous tissues (34.7%) (P=0.001). Positive DKC1 expression tends to significantly be associated with unfavorable clinicopathological characteristics such as tumor diameter>7 cm (P=0.002) and tumor‑node‑metastasis (TNM) stage III or IV (P
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Preliminary mechanisms of regulating PD ‑L1 expression in non‑small cell lung cancer during the EMT process.
Preliminary mechanisms of regulating PD‑L1 expression in non‑small cell lung cancer during the EMT process. Oncol Rep. 2018 Jun 05;: Authors: Li F, Zhu T, Yue Y, Zhu X, Wang J, Liang L Abstract Non‑small cell lung cancer (NSCLC) is one of the most severe malignant tumor types worldwide. Recent studies have reported an important role of PD‑L1 in mediating immune evasion in the tumor microenvironment. In addition, increasing research has indicated that the expression of PD‑L1 is related to the epithelial‑mesenchymal transition (EMT) process, but the related mechanisms remain to be explored. I...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cdc20 inhibitor apcin inhibits the growth and invasion of osteosarcoma cells.
Authors: Gao Y, Zhang B, Wang Y, Shang G Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor worldwide, primarily affecting children and adolescents. The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that is activated by its co‑activator Cdc20 during the metaphase‑anaphase transition. Apcin is a novel cell‑permeable molecule that blocks the interaction between APC/C and Cdc20. Cdc20 overexpression has been reported in various malignancies and plays an oncogenic role in tumorigenesis and tumor progression. In the present study, the antitumor properties of apcin, an i...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer.
Authors: Zhan Y, Zhang H, Dai B, Zhang Y, Zhang J, He L Abstract We recently reported that TPD7 suppressed tumor cell proliferation, and inhibited invasion, through the suppression of C-X-C chemokine receptor type 4 (CXCR4). In the present study, we investigated the anticancer effect of TPD7 on apoptosis and invasion of cervical cancer HeLa cells. Cell cycle analysis revealed that TPD7 decreased cyclin-dependent kinase (CDK)1 and cyclin D1 expression, and increased cyclin A expression, following S phase blockade. TPD7 induced chromatin condensation and significantly elevated the number of apoptotic c...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑150 promotes the proliferation and migration of non‑small cell lung cancer cells by regulating the SIRT2/JMJD2A signaling pathway.
In conclusion, our results demonstrated that miR‑150 plays an important role in the development of lung cancer by serving as an oncogene via the SIRT2/JMJD2A signaling pathway. PMID: 29901178 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Girdin regulates the proliferation and apoptosis of pancreatic cancer cells via the PI3K/Akt signalling pathway.
Authors: Wang S, Lei Y, Cai Z, Ye X, Li L, Luo X, Yu C Abstract Girdin functions as an Akt phosphorylation enhancer (APE), which expedites the proliferation and survival of many types of tumours. However, the influence of Girdin on pancreatic cancer and the underlying molecular mechanisms have yet to be uncovered. Hence, in the present study, we sought to elucidate the function of Girdin in pancreatic cancer malignancy, particularly its role in pancreatic cancer cell proliferation, migration and apoptosis. Immunohistochemistry (IHC) was used to evaluate Girdin expression in pancreatic cancer tissues and to analyse ...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fibroblast growth factor  18 promotes the growth, migration and invasion of MDA‑MB‑231 cells.
Fibroblast growth factor 18 promotes the growth, migration and invasion of MDA‑MB‑231 cells. Oncol Rep. 2018 Jun 07;: Authors: Yu Z, Lou L, Zhao Y Abstract Fibroblast growth factor 18 (FGF18) increases cell motility and invasion in colon tumors, and is linked with ovarian and lung tumors. Furthermore, the increased expression of FGF18 mRNA and protein has been associated with poor overall survival in cancer patients. However, its function has not been investigated in breast cancer. In the present study, we demonstrated that FGF18 promoted cell growth and metastasis in vitro and stimu...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of the potential oncogenes in glioblastoma based on bioinformatic analysis and elucidation of the underlying mechanisms.
Authors: Zhang Y, Xia Q, Lin J Abstract Glioblastoma (GBM) is a common malignant tumour in the human brain, but its molecular mechanisms have not been systematically evaluated. The aim of this study was to identify potential key oncogenes associated with the progression of GBM and to elucidate their mechanisms. The gene expression profile of GSE50161, selected from the Gene Expression Omnibus database, was analysed to find cancer‑associated genes and gene functions in GBM. In total, 486 differentially expressed genes, including 128 upregulated genes, were identified. The function and pathway enrichment of these g...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

uc.338 targets p21 and cyclin D1 via PI3K/AKT pathway activation to promote cell proliferation in colorectal cancer.
Authors: Zhang Y, Wang S, Qian W, Ji D, Wang Q, Zhang Z, Wang S, Ji B, Fu Z, Sun Y Abstract Ultraconserved regions (UCRs) are 481 segments that have been strictly conserved among many mammalian species for hundreds of years. Their transcribed products belong to long non‑coding RNAs and are closely involved in the progression of various tumors. uc.338 has been reported to promote cell proliferation in hepatocellular and lung cancers. However, the role of uc.338 in colorectal cancer (CRC) proliferation remains unclear. In the present study, we first detected the expression of uc.338 in human tissues and analyzed th...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Protein kinase D1 regulates hypoxic metabolism through HIF-1 α and glycolytic enzymes incancer cells.
This study suggests that PKD1 may be a potential target for microenvironment-directed tumor biotherapy. PMID: 29901206 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Aberrant expression of FoxP3 in a human T  cell line possessing regulatory T cell‑like function and exposed continuously to asbestos fibers.
Aberrant expression of FoxP3 in a human T cell line possessing regulatory T cell‑like function and exposed continuously to asbestos fibers. Oncol Rep. 2018 Jun 07;: Authors: Maeda M, Matsuzaki H, Yamamoto S, Lee S, Kumagai-Takei N, Yoshitome K, Min Y, Sada N, Nishimura Y, Otsuki T Abstract Prompted by the known carcinogenic activity of asbestos, our investigations revealed that asbestos causes a reduction in antitumor immunity. One mechanism involves the enhancement of regulatory T (Treg) cell function and volume assayed using MT‑2 original cells (Org), an HTLV‑1 immortalized human T ce...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

AAED1 modulates proliferation and glycolysis in gastric cancer.
Authors: Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y Abstract Gastric cancer is one of the most common and lethal malignancies globally, especially in East Asia. Although significant progress has been made in the diagnosis and treatment of the disease, the overall survival rate remains unchanged at 20‑25%. Thus, there is an urgent need for a better understanding of the disease. Recent years have witnessed the critical roles of aberrant cancer cell metabolism in the maintenance of malignant properties of cancer cells, and targeting cancer cell metabolism has been regarded as a novel aspect in the development of trea...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA PVT1 promotes epithelial‑mesenchymal transition via the TGF‑β/Smad pathway in pancreatic cancer cells.
Long non‑coding RNA PVT1 promotes epithelial‑mesenchymal transition via the TGF‑β/Smad pathway in pancreatic cancer cells. Oncol Rep. 2018 May 24;: Authors: Zhang X, Feng W, Zhang J, Ge L, Zhang Y, Jiang X, Peng W, Wang D, Gong A, Xu M Abstract Recent studies have revealed that overexpression of long non‑coding RNA (lncRNA) PVT1 is correlated with several types of cancer. However, its role in pancreatic cancer development remains to be clarified. In the present study, we found that PVT1 promoted the growth and the epithelial‑mesenchymal transition (EMT) of pancreatic cancer cells. We fir...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HSV ‑TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK.
HSV‑TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK. Oncol Rep. 2018 May 21;: Authors: Yi QY, Bai ZS, Cai B, Chen N, Chen LS, Yuan T, Mao JH Abstract Retinoblastoma is an severe ophthalmic disease and the most common type intraocular malignant tumor, particularly in infants. Currently, few drugs and therapies are available. Gene therapy has been considered to be a potential treatment to cure cancer effectively and Herpes simplex virus type 1 thymidine kinase/ganciclovir (HSV‑TK/GCV) is one type of suicide gene therapy that has been ext...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Elevated TFAP4 regulates lncRNA TRERNA1 to promote cell migration and invasion in gastric cancer.
Authors: Wu H, Liu X, Gong P, Song W, Zhou M, Li Y, Zhao Z, Fan H Abstract Cancer cell invasion and metastasis are the leading causes of the high mortality rates in patients with malignant tumors. There is accumulating evidence to indicate that dysregulated long non‑coding RNAs (lncRNAs) may be involved in the progression of tumor invasion and metastasis. However, the regulatory mechanisms of the aberrant expression of lncRNAs remain largely unknown, although the roles of lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared in prevalent cancer types in recent years. In the present study, ...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑218 promotes apoptosis of SW1417 human colon cancer cells by targeting c‑FLIP.
miR‑218 promotes apoptosis of SW1417 human colon cancer cells by targeting c‑FLIP. Oncol Rep. 2018 May 23;: Authors: Meng Q, Chen Y, Lian B, Shang Y, Yang H Abstract MicroRNAs (miRNAs) are suggested to act as either tumor oncogenes or tumor suppressors in different types of cancer. miRNA‑218 (miR‑218) is a type of short, non-coding RNA which is involved in gastric cancer development. In the present study, we evaluated the functions of miR‑218 in SW1417 human colon cancer cells and its potential mechanisms. Following overexpression of miR‑218 in human colon cancer cells, cell viability was d...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑1 inhibits the progression of colon cancer by regulating the expression of vascular endothelial growth factor.
In this study, the expression of miR‑1 in 111 CRC and paired normal tissue samples was measured using quantitative polymerase chain reaction analysis, and the association between miR‑1 expression and clinical characteristics was evaluated. miR‑1 was found to be significantly downregulated in CRC tissues compared with paired normal tissues, and in CRC cell lines compared with non‑cancer cells (P
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Montelukast, a cysteinyl leukotriene receptor antagonist, inhibits the growth of chronic myeloid leukemia cells through apoptosis.
Authors: Zovko A, Yektaei-Karin E, Salamon D, Nilsson A, Wallvik J, Stenke L Abstract The clinical outcome for patients with chronic myeloid leukemia (CML) has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs). However, their curative potential appears limited, probably as a consequence of TKI-resistant leukemic stem cells (LSCs) that persist as a result of aberrant pathways independent of the well-established oncoprotein Bcr-Abl. One such pathway involves signaling through leukotrienes (LTs), bioactive compounds that have been suggested to play a role in several other malignancies. ...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

shRNA ‑induced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells.
This study aimed to investigate the effect of shRNA‑induced knockdown of the SPERT gene on the proliferation and apoptosis of human colorectal cancer RKO cells. SPERT was screened based on the TCGA dataset, and SPERT expression, cell growth, proliferation and apoptosis were detected in shSPERT‑ and shCtrl‑transfected RKO cells. In addition, the SPERT‑related biological pathways were detected using a PathScan® Signaling Antibody Array Kit. We detected lower SPERT expression in shSPERT‑transfected RKO cells than in shCtrl‑transfected cells at both the translational and transcriptional levels (P
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Novel triple ‑positive markers identified in human non‑small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristics.
Novel triple‑positive markers identified in human non‑small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristics. Oncol Rep. 2018 May 24;: Authors: Satar NA, Fakiruddin KS, Lim MN, Mok PL, Zakaria N, Fakharuzi NA, Abd Rahman AZ, Zakaria Z, Yahaya BH, Baharuddin P Abstract Through the specific identification and direct targeting of cancer stem cells (CSCs), it is believed that a better treatment efficacy of cancer may be achieved. Hence, the present study aimed to identify a CSC subpopulation from adenocarcinoma cells (A549) as a model of non‑small c...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑92a‑3p inhibits the cell proliferation, migration and invasion of Wilms tumor by targeting NOTCH1.
In conclusion, miR‑92a‑3p blocks the progression of Wilms tumor by targeting NOTCH1. PMID: 29845267 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Luteolin reduces cancer ‑induced skeletal and cardiac muscle atrophy in a Lewis lung cancer mouse model.
In conclusion, from the current results, we conclude that luteolin is able to reduce inflammatory burden, downregulate the expression of genes associated with muscle protein breakdown, and protect skeletal and heart muscle from cancer‑induced wasting and loss in vivo. Therefore, luteolin has the potential to be developed into a novel anti‑cachetic agent. PMID: 29845270 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-152 inhibits cell proliferation of osteosarcoma by directly targeting Wnt/ β-catenin signaling pathway in a DKK1-dependent manner.
MicroRNA-152 inhibits cell proliferation of osteosarcoma by directly targeting Wnt/β-catenin signaling pathway in a DKK1-dependent manner. Oncol Rep. 2018 May 22;: Authors: Zhao X, Sun S, Xu J, Luo Y, Xin Y, Wang Y Abstract The function of microRNA‑152 for a cohort of patients with osteosarcoma and the influence on cell growth of osteosarcoma were studied. The expression of microRNA‑152 was downregulated in patients with osteosarcoma. The downregulation of microRNA‑152 promotes cell proliferation, decreases apoptosis, and suppresses LDH activity, caspase-3/9 activities and Bax/Bcl-2 and p53 ...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

E ‑cadherin regulates proliferation of colorectal cancer stem cells through NANOG.
E‑cadherin regulates proliferation of colorectal cancer stem cells through NANOG. Oncol Rep. 2018 May 24;: Authors: Tamura S, Isobe T, Ariyama H, Nakano M, Kikushige Y, Takaishi S, Kusaba H, Takenaka K, Ueki T, Nakamura M, Akashi K, Baba E Abstract Cancer stem cells (CSCs) possess a self‑renewal ability and display tumorigenic potential in immunodeficient mice. Colorectal CSCs are thought to be a uniform population and no functionally distinct subpopulations have been identified. Because E‑cadherin is an essential molecule for self‑renewal of embryonic stem cells, we examined E‑cadherin expre...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

RAD52 motif ‑containing protein 1 promotes non‑small cell lung cancer cell proliferation and survival via cell cycle regulation.
This study aimed to investigate the role of RDM1 in the progression of non‑small cell lung cancer (NSCLC). We found elevated RDM1 mRNA and protein expression in NSCLC tissues and cell lines compared to levels in normal lung cells. RDM1 protein expression in lung cancer tissues was found to correlate with tumor size, histological differentiation, lymph node metastasis and tumor‑node‑metastasis (TNM) stage. Knockdown of the RDM1 gene with siRNA significantly reduced the cellular proliferation rate and increased apoptosis in the human NSCLC cell line, NCI‑H1299. Compared to wild‑type NCI‑H1299 cells, RDM1 knockdow...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Dual mTOR/PI3K inhibitor NVP ‑BEZ235 arrests colorectal cancer cell growth and displays differential inhibition of 4E‑BP1.
Dual mTOR/PI3K inhibitor NVP‑BEZ235 arrests colorectal cancer cell growth and displays differential inhibition of 4E‑BP1. Oncol Rep. 2018 May 22;: Authors: Alqurashi N, Hashimi SM, Alowaidi F, Ivanovski S, Wei MQ Abstract The mammalian target of rapamycin (mTOR), a downstream effector of the PI3K/Akt signalling pathway, is a critical regulator of cell metabolism, growth and survival in response to oncogenic factors. Activation of mTOR frequently occurs in human tumours making it a crucial and validated target in the treatment of cancer. mTOR inhibitors such as rapamycin and its analogues decrease c...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Lysyl oxidase-like 2 is highly expressed in colorectal cancer cells and promotes the development of colorectal cancer.
Authors: Cui X, Wang G, Shen W, Huang Z, He H, Cui L Abstract Colorectal cancer (CRC) is the third most common type of cancer. In the present study, the expression and intracellular localization of lysyl oxidase-like 2 (LOXL2) protein in CRC were examined. Quantitative polymerase chain reaction and western blot analysis of LOXL2 mRNA and protein expression was performed for 40 pairs of CRC tumor and normal mucosa tissue samples. The immunohistochemical staining of tissue microarrays was performed to detect LOXL2 protein expression. LOXL2 was highly expressed in the extracellular matrix and CRC cells. The posit...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Microarray analysis of circular RNA expression profiles associated with gemcitabine resistance in pancreatic cancer cells.
Authors: Xu C, Yu Y, Ding F Abstract Pancreatic cancer (PC) is one of the most malignant tumors of the digestive system due to its rapid progression, metastasis and resistance to chemotherapy. Gemcitabine (GEM) chemotherapy is the first‑choice treatment for advanced PC. However, the effect of GEM‑based chemotherapy on PC is limited due to the development of chemoresistance, and the molecular mechanisms underlying this resistance have yet to be investigated. Circular RNAs (circRNAs), which can function as microRNA sponges, have been found to be involved in the development of several types of cancer. However, res...
Source: Oncology Reports - May 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Specific inhibitor of Notch ‑3 enhances the sensitivity of NSCLC cells to gemcitabine.
Specific inhibitor of Notch‑3 enhances the sensitivity of NSCLC cells to gemcitabine. Oncol Rep. 2018 May 16;: Authors: Hu BD, Guo J, Ye YZ, Du T, Cheng CS, Jiang Q, Liu RN, Zhang YB Abstract Notch‑3 is a receptor of the Notch signaling pathway and plays an important role in regulating self‑renewal, differentiation and apoptosis in cancer cells. Overexpression of Notch‑3 has been proved to be associated with resistance to gemcitabine (GEM) and poor patient prognosis for various malignant tumors. In the present study, two non‑small cell lung cancer (NSCLC) cell lines, H1299 and A549, were indu...
Source: Oncology Reports - May 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of KPNA2 inhibits autophagy in oral squamous cell carcinoma cell lines by blocking p53 nuclear translocation.
Authors: Lin F, Gao L, Su Z, Cao X, Zhan Y, Li Y, Zhang B Abstract Oral squamous cell carcinoma (OSCC), one of the 10 most common types of neoplasms in the US, constitutes ~90% of all cases of oral malignancies. Chemoresistance and metastasis are difficult to avoid during the course of treatment, leading to a poor prognosis and a high mortality rate for patients with OSCC. Autophagy, a critical conserved cellular process, has been reported to be highly associated with the regulation of chemoresistance and metastasis of cancer cells. The present study investigated the role of karyopherin α2 (KPNA2), a mem...
Source: Oncology Reports - May 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Correlation between HGF/c-Met and Notch1 signaling pathways in human gastric cancer cells.
Authors: Huang KH, Sung IC, Fang WL, Chi CW, Yeh TS, Lee HC, Yin PH, Li AF, Wu CW, Shyr YM, Yang MH Abstract In recent decades, research concerning gastric carcinogenesis has rapidly progressed. It is evident that hepatocyte growth factor (HGF) is clinically related to gastric cancer progression and metastasis. In addition, previous studies have found that expression of Notch ligand Jagged1 is correlated with the poor prognosis of gastric cancer. However, the interaction between the HGF/c-Met and Notch1 signaling pathways remains unknown. In the present study, we found that gastric cancer patients with positive c-M...
Source: Oncology Reports - May 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research