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Transdifferentiation of type II alveolar epithelial cells induces reactivation of dormant tumor cells by enhancing TGF- β1/SNAI2 signaling.
Transdifferentiation of type II alveolar epithelial cells induces reactivation of dormant tumor cells by enhancing TGF-β1/SNAI2 signaling. Oncol Rep. 2018 Feb 06;: Authors: Zhou Y, Liu Q, Dai X, Yan Y, Yang Y, Li H, Zhou X, Gao W, Li X, Xi Z Abstract Dormant tumor cells (DTCs) serve a crucial role in the pathogenesis of metastasis and may compromise the efficacy of existing therapeutic modalities aimed at fully eradicating cancer. However, the mechanisms underlying the dormant-to-proliferating switch of DTCs remain largely unknown. The lung is one of the most common sites of metastatic recurrence....
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-375 inhibits glioma cell proliferation and migration by downregulating RWDD3 in  vitro.
MicroRNA-375 inhibits glioma cell proliferation and migration by downregulating RWDD3 in vitro. Oncol Rep. 2018 Feb 13;: Authors: Ji CX, Fan YH, Xu F, Lv SG, Ye MH, Wu MJ, Zhu XG, Wu L Abstract Derived from brain glial cells, gliomas are currently the most common primary tumours in the central nervous system and are characterised by a high recurrence rate and poor prognosis. RWDD3 (RWD domain-containing sumoylation enhancer, also termed RSUME), which can be induced by cellular stress, such as CoCl2, heat shock and hypoxia, may play a crucial role in tumour angiogenesis, growth and metastasis. Micr...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma.
Authors: Wang X, Jin Y, Li YX, Yang Y Abstract Oral leukoplakia (OL) is one of the most common oral precancerous lesions with the possibility of malignant transformation, ranging from 17 to 24% of patients with a median follow-up of>7 years. Previous research has revealed that compared with normal oral epithelial tissues, the expression of secretory leukocyte peptidase inhibitor (SLPI) protein is significantly reduced in oral squamous cell carcinoma (OSCC). Based on the above-mentioned research, it is known that SLPI is a potential predictive and diagnostic tool for the progression of oral carcinogenesis. T...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals.
Authors: Park JH, Lee JM, Lee EJ, Kim DJ, Hwang WB Abstract Various amino acids regulate cell growth and differentiation. In the present study, we examined the ability of HT-29 cells to differentiate into goblet cells in RPMI and DMEM which are largely different in the amounts of numerous amino acids. Most of the HT-29 cells differentiated into goblet cells downregulating the stem cell marker Lgr5 when cultured in DMEM, but remained undifferentiated in RPMI. The goblet cell differentiation in DMEM was inhibited by 1-methyl-tryptophan (1-MT), an inhibitor of indoleamine 2,3 dioxygenase-1 which is the initial enzyme ...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Mechanism of ECM-induced dormancy and chemoresistance in A549 human lung carcinoma cells.
Authors: Keeratichamroen S, Lirdprapamongkol K, Svasti J Abstract It is now widely accepted that the tumor microenvironment influences the fate of cancer cells and plays crucial roles in regulating tumor dormancy and chemoresistance. The standard cell culture system on plastic surfaces does not account for cell interactions with the extracellular matrix (ECM), and is thus a less reliable approach to analyze cellular activity ex vivo. In the present study, A549 lung cancer cells were cultured in a semi-solid growth substrate (Matrigel) to mimic the tumor microenvironment and to investigate the role played by ECM pro...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.
Authors: Wang Q, Chen J, Wang A, Sun L, Qian L, Zhou X, Liu Y, Tang S, Chen X, Cheng Y, Cao K, Zhou J Abstract Circular RNAs (circRNAs) play critical roles in the occurrence of human diseases, including cancer. However, the detailed functions of circRNAs in melanoma have not been fully elucidated. In the present study, a circRNA microarray was performed to analyze the variability of circRNAs in the low-metastatic melanoma WM35 cell line and in the high-metastatic melanoma WM451 cell line in comparison to control human melanocytes. The results revealed that five circRNAs were upregulated and four circRNAs were downr...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The targeted inhibition of Hsp90 by a synthetic small molecule, DPide offers an effective treatment strategy against TNBCs.
Authors: Oh YJ, Park SY, Seo YH Abstract Triple-negative breast cancers (TNBCs) are the most aggressive and metastatic subtype of breast cancers and exhibit poor clinical outcome due to the lack of drug target receptors such as estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (Her2). The limited effectiveness of therapeutic options and the poor prognosis of TNBC patients emphasize the urgent need for identifying new therapeutic agents. In this regard, heat shock protein 90 (Hsp90) has emerged as a promising therapeutic target for the treatment of TNBCs. Hsp90 i...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Combination of salinomycin and radiation effectively eliminates head and neck squamous cell carcinoma cells in  vitro.
Combination of salinomycin and radiation effectively eliminates head and neck squamous cell carcinoma cells in vitro. Oncol Rep. 2018 Feb 13;: Authors: Gehrke T, Hackenberg S, Polat B, Wohlleben G, Hagen R, Kleinsasser N, Scherzad A Abstract The antibiotic drug salinomycin has been reported to mediate cancer cell-specific cytotoxicity, especially regarding cancer stem cells. Since salinomycin has also been reported to arrest cancer cells in the G2 phase, it may have possible radiosensitizing effects. Radiotherapy is a common therapeutic strategy for head and neck squamous cell carcinoma (HNSC...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Vandetanib inhibits cisplatin ‑resistant neuroblastoma tumor growth and invasion.
Vandetanib inhibits cisplatin‑resistant neuroblastoma tumor growth and invasion. Oncol Rep. 2018 Feb 09;: Authors: Li C, Yang C, Wei G Abstract Resistance is the major cause of cisplatin treatment failure in neuroblastoma (NB). Vandetanib is widely used in the treatment of several cancers. In the present study, we aimed to determine the potential of vandetanib in cisplatin‑resistant NB therapy. Immunohistochemistry (IHC) staining was employed to detect p‑RET and CXCR4 expression in cisplatin‑resistant or ‑sensitive NB tissues from patients. Vandetanib was added to treat selected cisplatin‑r...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells.
Authors: Ma X, Zhou X, Qu H, Ma Y, Yue Z, Shang W, Wang P, Xie S, Li Y, Sun Y Abstract Acquired resistance to chemotherapy plays a critical role in human drug treatment failure in many tumor types. Multidrug resistance (MDR) to Adriamycin (ADM) also limits the efficacy of therapy in human chronic myelogenous leukemia (CML). The overexpression of drug efflux transporters is one mechanism uderlying MDR. In particular, the consistent activation of MDR1 and MDR‑associated protein 1 (MRP1) is involved in drug resistance. In the present study, ADM‑resistant human CML K562/ADM cells were stably transfected with a Trib...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR-199a-3p enhances cisplatin sensitivity of ovarian cancer cells by targeting ITGB8.
Authors: Cui Y, Wu F, Tian D, Wang T, Lu T, Huang X, Zhang P, Qin L Abstract Drug resistance remains a large obstacle for the treatment of ovarian cancer. miRNAs have been reported to be involved in cisplatin (CDDP) resistance in ovarian cancer. The aim of the present study was to investigate the function and mechanism of miR-199a-3p in the CDDP resistance in ovarian cancer. We found that miR-199a-3p was significantly downregulated in chemoresistant ovarian cancer tissues, as well as CDDP-resistant SKOV3/CDDP cells, compared to chemosensitive carcinomas and SKOV3 cells. Restoration of miR-199a-3p in SKOV3/CDDP cell...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fatostatin suppresses growth and enhances apoptosis by blocking SREBP-regulated metabolic pathways in endometrial carcinoma.
Authors: Gao S, Shi Z, Li X, Li W, Wang Y, Liu Z, Jiang J Abstract Fatostatin, a chemical inhibitor of the sterol regulatory element‑binding protein (SREBP) pathway, has been reported to possess high antitumor activity against prostate and pancreatic cancer. The main aim of the present study was to investigate the effects and mechanism of fatostatin in endometrial carcinoma (EC). In the present study, we determined that fatostatin inhibited EC cell viability and colony formation capacity, decreased the invasive and migratory capacities of EC cells, induced EC cell cycle arrest at the G2/M phase and stimulate...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of angiopoietin-like 4 inhibits the development of human gastric cancer.
In conclusion, these findings suggest that ANGPTL4 may be a new potential therapeutic target for GC. PMID: 29436683 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anti-angiogenic and pro-apoptotic effects of a small-molecule JFD-WS in in vitro and breast cancer xenograft mouse models.
Authors: Rathinavelu A, Kanagasabai T, Dhandayuthapani S, Alhazzani K Abstract A small molecule that was developed for blocking vascular endothelial growth factor receptor 2 (VEGFR2) has been tested and confirmed for its anti-angiogenic activity. Subsequently, it was modified into a water soluble salt form (JFD-WS) to increase bioavailability and distribution during in vivo pre-clinical testing. The present study was designed to further evaluate the anti-angiogenic and pro-apoptotic effects of JFD-WS in monotherapy as well as in combination with paclitaxel (Taxol) using a mouse xenograft model. The in&nbs...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of the long non-coding RNA XLOC_010588 inhibits the invasion and migration of colorectal cancer.
Authors: Li Y, Zhao L, Zhang Y, Guan L, Zhang H, Zhou H, Gao T, Miao P, Sun M Abstract Long non-coding RNAs (lncRNAs) have emer-ged as major players in many biological and pathological processes; however, investigation into the function of lncRNAs in the development and progression of cancer is in its infancy. Therefore, clarification of the mechanism by which cancer‑related lncRNAs function is of critical importance in research on tumorigenesis. It has been demonstrated that the lncRNA XLOC_010588 is expressed at a low level in cervical cancer, and that this has significant impact on the proliferation of cervica...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-655 attenuates the malignant biological behaviours of retinoblastoma cells by directly targeting PAX6 and suppressing the ERK and p38  MAPK signalling pathways.
MicroRNA-655 attenuates the malignant biological behaviours of retinoblastoma cells by directly targeting PAX6 and suppressing the ERK and p38 MAPK signalling pathways. Oncol Rep. 2018 Feb 13;: Authors: Zhang M, Li Q, Pan Y, Wang H, Liu G, Yin H Abstract Numerous studies have indicated that microRNAs (miRNAs) regulate signalling molecules by acting as oncogenes or tumour-suppressor genes in retinoblastoma (RB). Therefore, investigation of the expression pattern, biological roles and associated mechanisms of cancer-related miRNAs in RB may provide novel therapeutic targets for patients with this di...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of low-intensity ultrasound combined with low-dose carboplatin in an orthotopic hamster model of tongue cancer: A preclinical study.
Authors: Li HX, Zheng JH, Ji L, Liu GY, Lv YK, Yang D, Hu Z, Chen H, Zhang FM, Cao W Abstract Low-intensity ultrasound (LIUS) combined with chemotherapy is an innovative modality for cancer treatment, but its effect on orthotopic carcinoma remains unknown. Our previous study revealed that LIUS enhanced the growth inhibitory effects of several chemotherapeutic drugs in nude mice with transplanted tumors. In the present study, we used 7,12-dimethylbenz(alpha)anthracene to induce orthotopic tongue carcinogenesis in hamsters. We used the first-line chemotherapy drug for tongue cancer, carboplatin (CBP) in combination w...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review).
Authors: Pappa KI, Kontostathi G, Lygirou V, Zoidakis J, Anagnou NP Abstract Cervical cancer incidence is tightly linked to HPV infection, and particularly virus types 16 and 18 cause the majority of cases presenting with pre-cancerous stages of cervical intraepithelial neoplasia (CIN). Structural and functional information concerning HPV proteins can offer novel insight into the mechanism(s) of cancer progression in the cervical epithelium. Recently, novel structural determinants of the interactions of viral proteins with their targets in keratinocytes have been elucidated. These exciting findings o...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Synergistic antitumor effects of histone deacetylase inhibitor scriptaid and bortezomib against ovarian cancer cells.
Authors: Janyst K, Janyst M, Siernicka M, Lasek W Abstract Despite debulking surgery and good initial response to chemotherapy, the majority of patients with advanced ovarian cancer relapse and succumb to their disease. Thus, there is a pressing need to improve treatment outcome. In the present study, the antitumor activity of histone deacetylase (HDAC) inhibitor scriptaid in combination with bortezomib or conventional chemotherapeutics was tested in vitro against representative ovarian cancer cell lines: SKOV‑3, MDAH 2774, and OVP‑10. Incubation of ovarian cancer cells with scriptaid and bortezomib (...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy.
Authors: Yan H, Qiu C, Sun W, Gu M, Xiao F, Zou J, Zhang L Abstract Gastric cancer is the fifth most common cancer worldwide and Hippo-Yap is the novel signaling pathway which plays an important role in gastric cancer tumor development and progression. However, little insight is available to date regarding the specific role of Yes-associated protein (Yap) in gastric cancer. In the present study, we identified the mechanism through which Yap sustains gastric cancer viability and migration. Yap was greatly upregulated in gastric cancer cells and its expression promoted cellular migration and survival. Functional stud...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver.
Authors: Benedicto A, Romayor I, Arteta B Abstract The liver is a common site for the metastatic spread of primary malignancies including colorectal cancer, and liver metastasis is a main cause of death in cancer patients. This is due to the complexity of the interactions taking place in the liver between tumor and stromal cells. In fact, cancer‑associated fibroblasts (CAFs) have been shown to support tumor growth through the CXCL12/CXCR4 axis. However, along with cancer cells, myeloid‑derived suppressor cells (MDSCs), immature dendritic cells with immunosuppressive potential, also express CXCR4. It has recentl...
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Mechanisms of the CDK4/6 inhibitor palbociclib (PD 0332991) and its future application in cancer treatment (Review).
Authors: Liu M, Liu H, Chen J Abstract An uncontrolled cell cycle is an obvious marker of tumor cells. The G1‑S phase is an important restriction point in the normal cell cycle, but in cancer cells the restriction function is reduced, leading to uncontrolled cell proliferation. Two cyclin‑dependent kinases (CDKs), CDK4 and CDK6, play a crucial role in the G1‑S phase transition. Inhibitors of CDK4/6 are presently the subjects of numerous studies, and PD 0332991, an inhibitor of CDK4/6, has been used to treat hormone receptor (HR)‑positive, advanced‑stage breast cancer. This inhibitor has also bee...
Source: Oncology Reports - February 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑16/VEGFR2/p38/NF‑κB signaling pathway regulates cell growth of human pituitary neoplasms.
MicroRNA‑16/VEGFR2/p38/NF‑κB signaling pathway regulates cell growth of human pituitary neoplasms. Oncol Rep. 2018 Jan 22;: Authors: Lu B, Liu GL, Yu F, Li WJ, Xiang XX, Xiao HZ Abstract The association of microRNA (miRNA) with tumor has gradually become an active medical research field, since its discovery in 1993. The aim of the present study was to clarify how microRNA‑16 expression affects the proliferation and survival of pituitary tumor, revealing its potential mechanism. MicroRNA‑16 expression of pituitary tumor patients was observably declined, compared with the normal group. A hi...
Source: Oncology Reports - February 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fra ‑1 enhances the radioresistance of colon cancer cells to X‑ray or C‑ion radiation.
Fra‑1 enhances the radioresistance of colon cancer cells to X‑ray or C‑ion radiation. Oncol Rep. 2018 Jan 19;: Authors: Endo S, Fujita M, Yamada S, Imadome K, Nakayama F, Isozaki T, Yasuda T, Imai T, Matsubara H Abstract Fos‑related antigen 1 (Fra‑1) has roles in a variety of cell functions, including cell proliferation, differentiation, transformation, and invasiveness, and it is upregulated in various cancers. We investigated the role of Fra‑1 in cellular radioresistance using cells of two human colorectal cancer cell lines, SW620 and SW480. We found that SW620 cells are more sensitive th...
Source: Oncology Reports - February 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production.
Authors: Ramírez De Arellano A, Riera Leal A, Lopez-Pulido EI, González-Lucano LR, Macías Barragan J, Del Toro Arreola S, García-Chagollan M, Palafox-Sánchez CA, Muñoz-Valle JF, Pereira-Suárez AL Abstract Prolactin (PRL) is associated with different types of cancer, such as cervical cancer. Recombinant PRL has antiapoptotic effect on cervical cancer cells, and it can also induce cytokine production on macrophages. A 60 kDa variant of PRL is produced by cervical cancer cells. The aim of the present study was to evaluate this variant's bioactivity, to test its eff...
Source: Oncology Reports - February 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-125 modulates radioresistance through targeting p21 in cervical cancer.
Authors: Pedroza-Torres A, Campos-Parra AD, Millan-Catalan O, Loissell-Baltazar YA, Zamudio-Meza H, Cantú de León D, Montalvo-Esquivel G, Isla-Ortiz D, Herrera LA, Ángeles-Zaragoza Ó, Robelo-Romero G, Herrera-Gómez Á, Pérez-Plasencia C Abstract Cervical cancer (CC) is one of the most common cancers diagnosed in women worldwide, and it is estimated that ~500,000 new patients are diagnosed with cervical cancer annually and that ~270,000 deaths occur each year. Patients with cervical cancer are treated with different radiotherapy schedules, either alone or wit...
Source: Oncology Reports - February 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The role of aldehyde dehydrogenase 1A1 in B-cell non-Hodgkin's lymphoma.
Authors: Song YH, Zhong MZ, Chai Q, Gong KY, Tan XL, Hu JY, Wang GH Abstract Previously we showed that aldehyde dehydrogenase 1A1 (ALDH1A1) is a new mediator for resistance of DLBCL to CHOP and a facility predictor of clinical prognosis. In the present study, knockdown and inhibitor of ALDH1A1 were applied to identify the role of ALDH1A1 in Raji cells. CCK-8 and clone formation assay were applied to determine the CHOP sensitivity and clone formation ability. Caspase colorimetric assay and Annexin V/FITC staining was performed to determine the degree of apoptosis. Western blot analysis was used to detect t...
Source: Oncology Reports - February 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

NEK2 promotes hepatocellular carcinoma migration and invasion through modulation of the epithelial-mesenchymal transition.
Authors: Zhang Y, Wang W, Wang Y, Huang X, Zhang Z, Chen B, Xie W, Li S, Shen S, Peng B Abstract Never in mitosis gene-A (NIMA)-related expressed kinase 2 (NEK2) has been recently reported to play a role in tumor progression, drug resistance and tumorigenesis. However, little is known about the effects of NEK2 in hepatocellular carcinoma (HCC) metastasis and the underlying mechanism. NEK2 expression levels were examined by immunochemistry, qRT‑PCR and western blot analyses in HCC cell lines and HCC tissues. A Transwell assay was used to determine the migration and invasion capacity of NEK2-silenced or NEK2-o...
Source: Oncology Reports - February 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sigma-1 receptor ( σ1R) is downregulated in hepatic malignant tumors and regulates HepG2 cell proliferation, migration and apoptosis.
Sigma-1 receptor (σ1R) is downregulated in hepatic malignant tumors and regulates HepG2 cell proliferation, migration and apoptosis. Oncol Rep. 2018 Jan 22;: Authors: Xu Q, Li L, Han C, Wei L, Kong L, Lin F Abstract Sigma-1 receptor (σ1R), an important transmembrane structural protein, has been demonstrated to be overexpressed in various types of human cancer, and has been confirmed to be involved in many biological behaviors during tumorigenesis and tumor progression. The aim of the present study was to explore the essential role of σ1R in hepatic malignant tumors (HMTs), which, to t...
Source: Oncology Reports - February 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma.
Authors: Yun DP, Wang YQ, Meng DL, Ji YY, Chen JX, Chen HY, Lu DR Abstract Glioma is the most aggressive and malignant primary brain tumor in adults. In the present study, we identified a vital oncoprotein, capping actin protein, gelsolin-like (CapG), and investigated its roles in the prognosis, proliferation and metastasis in glioma. The mRNA and protein levels of CapG were significantly increased in human glioma, and higher CapG expression was an independent prognostic factor for predicting unfavorable prognosis. The expression level of CapG was found to be associated with several common molecular features of gli...
Source: Oncology Reports - February 7, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

β‑carotene reverses tobacco smoke‑induced gastric EMT via Notch pathway in vivo.
β‑carotene reverses tobacco smoke‑induced gastric EMT via Notch pathway in vivo. Oncol Rep. 2018 Feb 02;: Authors: Lu L, Chen J, Li M, Tang L, Wu R, Jin L, Liang Z Abstract Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid present in fruits, vegetables and rice, suppresses cancer progression. In this investigation, we evalu...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Aurora-A overexpression is linked to development of aggressive teratomas derived from humans iPS cells.
Authors: Ohmine S, Salisbury JL, Ingle J, Pettinato G, Haddox CL, Haddad T, Galanis E, Ikeda Y, D'assoro AB Abstract The discovery of human induced pluripotent stem cells (hiPSCs) is a promising advancement in the field of regenerative and personalized medicine. Expression of SOX2, KLF4, OCT4 and MYC transcription factors induces the nuclear reprogramming of somatic cells into hiPSCs that share striking similarities with human embryonic stem cells (hESCs). However, several studies have demonstrated that hESCs and hiPSCs could lead to teratoma formation in vivo, thus limiting their current clinical applications...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PARP1-siRNA suppresses human prostate cancer cell growth and progression.
Authors: Lai Y, Kong Z, Zeng T, Xu S, Duan X, Li S, Cai C, Zhao Z, Wu W Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors, such as olaparib or rucaparib, have shown treatment efficacy in BRCA1/2-deficient tumors. However, since PARP inhibitors (PARPi) mainly modulate the activation of PARP but not its expression, whether small interfering RNA (siRNA) specific to PARP has the same function as PARPi has not been well defined. In the present study it was demonstrated that PARP1-siRNA could reduce prostate cancer (PCa) cell progression regardless of the BRCA1/2 mutation. PARP1 silencing could significantly inhibi...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling.
Authors: Zhang X, Lu H, Hong W, Liu L, Wang S, Zhou M, Chen B, Bai Y Abstract Drug-resistance is the key reason for the ineffectiveness of chemotherapy in pancreatic cancer. Thus, it is very important to explore the molecular mechanisms of drug‑resistance and the methods of effective intervention. In the present study, we investigated the effect of tyrphostin B42, also called AG490, on histone deacetylase (HDAC) inhibitor trichostatin A (TSA)‑induced resistance in pancreatic cancer cells (PCCs). Evidence from phase contrast microscope revealed that TSA‑resistant cells (PANC‑1‑TSA) had higher prolifer...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Puerarin inhibits non-small cell lung cancer cell growth via the induction of apoptosis.
Authors: Hu Y, Li X, Lin L, Liang S, Yan J Abstract Puerarin, an isoflavone isolated from Kudzu roots, has been demonstrated to have beneficial effect on cardiovascular and cerebral vascular diseases. Recently research has revealed that puerarin exerts an anticancer role in many different types of cancer. The aim of the present study was to investigate the antitumor effects of puerarin on non-small cell lung cancer (NSCLC). Treatment of puerarin significantly inhibited the growth of NSCLC cell lines as determined by CCK-8 kit in vitro. Flow cytometry results indicated that puerarin treatments promoted NSCLC ce...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL-6-stimulated liver cancer cells.
Authors: Kim B, Park B Abstract Signal transducer and activator of transcription 3 (STAT3) is involved in the survival, proliferation, angiogenesis, invasion and metastasis of tumor cells. In addition, interleukin-6 (IL-6) has been reported to be closely related to STAT3 activity. In the present study, we investigated whether crocin, a major glycosylated carotenoid derived from saffron, can modulate the IL-6/STAT3 pathway to induce growth inhibition and sensitivity to cancer cell apoptosis. We determined that crocin inhibited STAT3 activation induced by IL-6 in hepatocellular carcinoma Hep3B and HepG2 cells. S...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TRIM28 promotes cervical cancer growth through the mTOR signaling pathway.
In this study, we compared TRIM28 expression between cervical cancer and adjacent normal tissues, and detected significant elevation in TRIM28 expression levels in the cervical cancer tissues. Moreover, TRIM28 overexpression promoted the proliferation, colony formation, and cell cycle progression of cervical cancer cell lines, as well as the growth of xenograft tumors in nude mice, whereas knockdown of TRIM28 had the opposite effects. Evaluation of the potential mechanism demonstrated that TRIM28 promoted cervical cancer cell growth by activating the mammalian target of rapamycin (mTOR) signaling pathway. In support o...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells.
Authors: Zhao J, Geng L, Duan G, Xu W, Cheng Y, Huang Z, Zhou Z, Gong S Abstract REC8 is a component of the meiotic cohesion complex that plays a critical role in chromosome dynamics during meiosis. However, the functional role of REC8 in gastric cancer has not been elucidated. In the present study, REC8 suppressed the growth and metastasis of gastric cancer cells in vitro. Whole Human Genome Oligo Microarray results revealed that a wide range of genes with broad function were targeted by REC8. Among them early growth response-1 (EGR1), a transcription factor and an epithelial-mesenchymal transition (EMT)-asso...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment.
Authors: Zhong Z, Zhang H, Hong M, Sun C, Xu Y, Chen X, Gao C, He M, Liu W, Liang J Abstract The primary reasons for the treatment failure of patients with oral tongue squamous cell carcinoma (OTSCC) are metastasis and tumor recurrence. Identifying the exact mechanisms underlying metastasis is a key point in improving patient prognosis. It has been reported that a hypoxic microenvironment plays an important role during the metastasis of malignancies. We found that the expression of fibronectin type III domain containing 3B (FNDC3B) is positively correlated with lymph node metastasis and advanced cTNM stage of OTSCC...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Co-treatment with gemcitabine and nab-paclitaxel exerts additive effects on pancreatic cancer cell death.
Authors: Passacantilli I, Panzeri V, Terracciano F, Delle Fave G, Sette C, Capurso G Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer and current treatments exert small effects on life expectancy. The most common adjuvant treatment for PDAC is gemcitabine. However, relapse almost invariably occurs and most patients develop metastatic, incurable disease. The aim of the present study was to assess the activity of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) alone or in combination with gemcitabine in PDAC cell lines displaying different degrees of sensitivity to gemcitabine tre...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Synergistic effect of metformin and medroxyprogesterone 17 ‑acetate on the development of endometrial cancer.
Synergistic effect of metformin and medroxyprogesterone 17‑acetate on the development of endometrial cancer. Oncol Rep. 2018 Jan 26;: Authors: Mu N, Dong M, Li L, Xia M, Qv L, Wang Y, Dong C, Chen Y, Zuo Y, Hou J, Xue F Abstract Accumulating data indicate that insulin resistance and unopposed estrogen are important risk factors of endometrial cancer (EC). Medroxyprogesterone 17‑acetate (MPA) has been used in the treatment of EC for many years. However, the therapeutic effect of this agent on EC has not been satisfactory. 36 arMetformin was recently reported to be a promising agent for the treatment...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sensitivity to chemotherapeutics of NSCLC cells with acquired resistance to EGFR-TKIs is mediated by T790M mutation or epithelial-mesenchymal transition.
Authors: Zhou J, Hu Q, Zhang X, Zheng J, Xie B, Xu Z, Zhang W Abstract Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms of acquired EGFR-TKIs resistance. Thus, the present study aimed to investigate the sensitivity of distinct gefitinib-resistant NSCLC cell lines to chemotherapy in order to help select effective treatment regimens for patients with E...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer.
Authors: Seo YS, Kang OH, Kong R, Zhou T, Kim SA, Ryu S, Kim HR, Kwon DY Abstract Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) and it has a similar structure to platycodin D, which is a well known anticancer agent. In the present study, we investigated the anti-proliferative effects of PGD using NSCLC cell lines. We evaluated the effects of PGD on proliferation, apoptosis and cell cycle arrest in A549 and H460 cells. PGD significantly induced apoptosis and nuclear condensation in both cell lines. Furthermore, PGD upregulated the cleavage of apoptotic proteins such a...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Short hairpin RNA-mediated gene silencing of ADAM17 inhibits the growth of breast cancer MCF ‑7 cells in vitro and in vivo and its mechanism of action.
Short hairpin RNA-mediated gene silencing of ADAM17 inhibits the growth of breast cancer MCF‑7 cells in vitro and in vivo and its mechanism of action. Oncol Rep. 2018 Jan 26;: Authors: Hu B, Meng X, Zhang Y, Hossain MM, Wu L, Zhang Y, Peng X, Zhang X Abstract A disintegrin and metalloprotease 17 (ADAM17) is highly expressed in many malignant tumors and is closely related to their development. We showed in a previous study that silencing of ADAM17 by siRNA inhibited the growth of MCF‑7 breast cancer cells in vitro and in vivo. In the present study, we investigated the effect...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of sinomenine hydrochloride on radiosensitivity of esophageal squamous cell carcinoma cells.
Authors: Fu S, Jin L, Gong T, Pan S, Zheng S, Zhang X, Yang T, Sun Y, Wang Y, Guo J, Hui B, Zhang X Abstract Radiation therapy is one of the most important treatments for unresectable and locally advanced esophageal squamous cell carcinoma (ESCC), however, the response to radiotherapy is sometimes limited by the development of radioresistance. Sinomenine hydrochloride (SH) has anticancer activity, but its effect on the radiosensitivity of ESCC is unclear. We determined the effect of SH on the radiosensitivity of ESCC cells and elucidated its potential radiosensitization mechanisms in vitro and in vivo. ES...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

β3GnT8 regulates oxaliplatin resistance by altering integrin β1 glycosylation in colon cancer cells.
β3GnT8 regulates oxaliplatin resistance by altering integrin β1 glycosylation in colon cancer cells. Oncol Rep. 2018 Feb 01;: Authors: Shen L, Dong X, Wang Y, Qiu L, Peng F, Luo Z Abstract Correlations between drug resistance and glycosylation changes have been analyzed intensively in the field of tumor biology. The present study was aimed to investigate the glycan and glycogene alterations involved in oxaliplatin resistance in human colon cancer cells. Using the lectin microarray for glycan composition and FITC-lectin binding for glycan profiling, we found that polylactosamine-type N-gl...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of MUS81 improves the chemical sensitivity of olaparib by regulating MCM2 in epithelial ovarian cancer.
This study aimed to investigate the biological effects and mechanisms of MUS81 on cellular responses to chemotherapeutic drugs. To accomplish this, we downregulated MUS81 and MCM2 in A2780 and SKOV3 ovarian cancer cells using lentivirus-mediated RNAi. Using a qPCR-based HR assay kit to detect HR efficiency. The sensitivity of MUS81 to olaparib was investigated by cell proliferation, colony formation assays and flow cytometry. The results showed that MUS81 modulates MCM2 levels as well as homologous recombination (HR) activity. Moreover, downregulation of MUS81 increased the sensitivity of EOC cells to olaparib by inducing ...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR-195 inhibits cell proliferation and angiogenesis in human prostate cancer by downregulating PRR11 expression.
Authors: Cai C, He H, Duan X, Wu W, Mai Z, Zhang T, Fan J, Deng T, Zhong W, Liu Y, Zhong W, Zeng G Abstract hsa-miR-195-5p (miR-195) has been proven to be a critical regulator in the progression of prostate cancer (PCa). To identify additional targets and molecular functions of miR-195, we overexpressed miR-195 by transient oligonucleotide transfection in DU145 and LNCaP cells and examined the effects. RNA-based microarray and dual-luciferase assays were carried out to identify novel targets of miR-195, while in vitro functional assays, a subcutaneous xenograft model, tissue microarray (TMA) analysis and a coh...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non-coding RNA XIST exerts oncogenic functions in pancreatic cancer via miR-34a-5p.
Authors: Sun Z, Zhang B, Cui T Abstract Long non-coding RNAs (lncRNAs) have been implicated in the occurrence and progression of multiple cancers. In the present study, we investigated the role of lncRNA X inactive-specific transcript (XIST) in the development and progression of pancreatic cancer (PC). Firstly, we found that lncRNA XIST was markedly upregulated in PC tissues and PC cell lines, respectively. Overexpression of XIST significantly promoted the proliferation, migration and invasion, and suppressed cell apoptosis of BxPC-3 cells; knockdown of XIST significantly inhibited the proliferation, migration...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E ‑BP1 in nasopharyngeal carcinoma cells.
Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Jan 16;: Authors: Xia Y, Liu X, Zou C, Feng S, Guo H, Yang Y, Lei Y, Zhang J, Lu Y Abstract Nasopharyngeal carcinoma (NPC) is one of the most common head and neck malignancies and is typically treated with radiotherapy and chemotherapy. Garcinone C, a natural compound isolated from Garcinia oblongifolia Champ., is a xanthone derivative with potential cytotoxic effects on certain cancers. However, there are limited studies regarding its effects on NPC cell...
Source: Oncology Reports - January 19, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research