Downregulation of MCM8 expression restrains the malignant progression of cholangiocarcinoma
Oncol Rep. 2021 Nov;46(5):235. doi: 10.3892/or.2021.8186. Epub 2021 Sep 15.ABSTRACTCholangiocarcinoma (CCA) is a highly aggressive malignant tumor with an extremely poor prognosis. Minichromosome maintenance 8 homologous recombination repair factor (MCM8) is a helicase involved in the elongation step of DNA replication and tumorigenesis. In the present study, the clinical significance and biological function of MCM8 in CCA were investigated. The expression levels of MCM8 in CCA and paracancerous tissues were analyzed using immunohistochemical staining. The potential mechanisms underlying MCM8 and the biological effects of ...
Source: Oncology Reports - September 15, 2021 Category: Cancer & Oncology Authors: Jingcheng Hao Haimin Deng Yuan Yang Lidan Chen Qiang Wu Pei Yao Junen Li Bowen Li Xueli Jin Haiqing Wang Huaxin Duan Source Type: research

Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation
Oncol Rep. 2021 Nov;46(5):234. doi: 10.3892/or.2021.8185. Epub 2021 Sep 13.ABSTRACTThe activation of Wnt signaling has been detected in various types of human cancer and has been shown to be associated with cancer development. In the present study, it was revealed that Wnt signaling induced the expression of phosphofructokinase 1 platelet isoform (PFKP), which has been reported to catalyze a rate‑limiting reaction in glycolysis and is important for the Warburg effect, proliferation, colony formation and cancer cell migration. Moreover, it was demonstrated that Wnt3A induced PFKP expression in a β‑catenin‑indepen...
Source: Oncology Reports - September 13, 2021 Category: Cancer & Oncology Authors: So Mi Jeon Je Sun Lim Su Hwan Park Jong-Ho Lee Source Type: research

Natural killer cell ‑based immunotherapy for lung cancer: Challenges and perspectives (Review)
Oncol Rep. 2021 Nov;46(5):232. doi: 10.3892/or.2021.8183. Epub 2021 Sep 9.ABSTRACTDespite the marked success of molecular targeted therapy in lung cancer in this era of personalized medicine, its efficacy has been limited by the presence of resistance mechanisms. The prognosis of patients with lung cancer remains poor, and there is an unmet need to develop more effective therapies to improve clinical outcomes. The increasing insight into the human immune system has led to breakthroughs in immunotherapy and has prompted research interest in employing immunotherapy to treat lung cancer. Natural killer (NK) cells, which serve...
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Yongqin Zeng Xiuzhi Lv Juan Du Source Type: research

Lipidomic profiling reveals lipid regulation by a novel LSD1 inhibitor treatment
In conclusion, our research reveals a link between LSD1 and lipid metabolism in cancer cells, offering more comprehensive evidence for the application of LSD1 inhibitors for cancer therapy. The underlying mechanisms of how the LSD1 inhibitor regulates lipid metabolism warrant further investigation.PMID:34498714 | DOI:10.3892/or.2021.8184 (Source: Oncology Reports)
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Yan Li Xinying Qian Yiyun Lin Lei Tao Zeping Zuo Huaqin Zhang Shengyong Yang Xiaobo Cen Yinglan Zhao Source Type: research

[Retracted] miR ‑363 inhibits the growth, migration and invasion of hepatocellular carcinoma cells by regulating E2F3
Oncol Rep. 2021 Nov;46(5):230. doi: 10.3892/or.2021.8181. Epub 2021 Sep 9.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that tumour images featured in Fig. 2E were strikingly similar to those that had already appeared in different form in another article by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published elsewhere prior to its submission to Oncology Reports, the Editor has decided that this paper should be retracted from the Journal. After having been in contact wit...
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Junfeng Ye Wei Zhang Songyang Liu Yahui Liu Kai Liu Source Type: research

Metastatic pancreatic cancer: Mechanisms and detection (Review)
Oncol Rep. 2021 Nov;46(5):231. doi: 10.3892/or.2021.8182. Epub 2021 Sep 9.ABSTRACTPancreatic cancer (PC) is a lethal malignancy. Its prevalence rate remains low but continues to grow each year. Among all stages of PC, metastatic PC is defined as late‑stage (stage IV) PC and has an even higher fatality rate. Patients with PC do not have any specific clinical manifestations. Most cases are inoperable at the time‑point of diagnosis. Prognosis is also poor even with curative‑intent surgery. Complications during surgery, postoperative pancreatic fistula and recurrence with metastatic foci make the management of metastatic...
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Xiangling Chen Fangfang Liu Qingping Xue Xiechuan Weng Fan Xu Source Type: research

Natural killer cell ‑based immunotherapy for lung cancer: Challenges and perspectives (Review)
Oncol Rep. 2021 Nov;46(5):232. doi: 10.3892/or.2021.8183. Epub 2021 Sep 9.ABSTRACTDespite the marked success of molecular targeted therapy in lung cancer in this era of personalized medicine, its efficacy has been limited by the presence of resistance mechanisms. The prognosis of patients with lung cancer remains poor, and there is an unmet need to develop more effective therapies to improve clinical outcomes. The increasing insight into the human immune system has led to breakthroughs in immunotherapy and has prompted research interest in employing immunotherapy to treat lung cancer. Natural killer (NK) cells, which serve...
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Yongqin Zeng Xiuzhi Lv Juan Du Source Type: research

Lipidomic profiling reveals lipid regulation by a novel LSD1 inhibitor treatment
In conclusion, our research reveals a link between LSD1 and lipid metabolism in cancer cells, offering more comprehensive evidence for the application of LSD1 inhibitors for cancer therapy. The underlying mechanisms of how the LSD1 inhibitor regulates lipid metabolism warrant further investigation.PMID:34498714 | DOI:10.3892/or.2021.8184 (Source: Oncology Reports)
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Yan Li Xinying Qian Yiyun Lin Lei Tao Zeping Zuo Huaqin Zhang Shengyong Yang Xiaobo Cen Yinglan Zhao Source Type: research

[Retracted] miR ‑363 inhibits the growth, migration and invasion of hepatocellular carcinoma cells by regulating E2F3
Oncol Rep. 2021 Nov;46(5):230. doi: 10.3892/or.2021.8181. Epub 2021 Sep 9.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that tumour images featured in Fig. 2E were strikingly similar to those that had already appeared in different form in another article by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published elsewhere prior to its submission to Oncology Reports, the Editor has decided that this paper should be retracted from the Journal. After having been in contact wit...
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Junfeng Ye Wei Zhang Songyang Liu Yahui Liu Kai Liu Source Type: research

Metastatic pancreatic cancer: Mechanisms and detection (Review)
Oncol Rep. 2021 Nov;46(5):231. doi: 10.3892/or.2021.8182. Epub 2021 Sep 9.ABSTRACTPancreatic cancer (PC) is a lethal malignancy. Its prevalence rate remains low but continues to grow each year. Among all stages of PC, metastatic PC is defined as late‑stage (stage IV) PC and has an even higher fatality rate. Patients with PC do not have any specific clinical manifestations. Most cases are inoperable at the time‑point of diagnosis. Prognosis is also poor even with curative‑intent surgery. Complications during surgery, postoperative pancreatic fistula and recurrence with metastatic foci make the management of metastatic...
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Xiangling Chen Fangfang Liu Qingping Xue Xiechuan Weng Fan Xu Source Type: research

Natural killer cell ‑based immunotherapy for lung cancer: Challenges and perspectives (Review)
Oncol Rep. 2021 Nov;46(5):232. doi: 10.3892/or.2021.8183. Epub 2021 Sep 9.ABSTRACTDespite the marked success of molecular targeted therapy in lung cancer in this era of personalized medicine, its efficacy has been limited by the presence of resistance mechanisms. The prognosis of patients with lung cancer remains poor, and there is an unmet need to develop more effective therapies to improve clinical outcomes. The increasing insight into the human immune system has led to breakthroughs in immunotherapy and has prompted research interest in employing immunotherapy to treat lung cancer. Natural killer (NK) cells, which serve...
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Yongqin Zeng Xiuzhi Lv Juan Du Source Type: research

Lipidomic profiling reveals lipid regulation by a novel LSD1 inhibitor treatment
In conclusion, our research reveals a link between LSD1 and lipid metabolism in cancer cells, offering more comprehensive evidence for the application of LSD1 inhibitors for cancer therapy. The underlying mechanisms of how the LSD1 inhibitor regulates lipid metabolism warrant further investigation.PMID:34498714 | DOI:10.3892/or.2021.8184 (Source: Oncology Reports)
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Yan Li Xinying Qian Yiyun Lin Lei Tao Zeping Zuo Huaqin Zhang Shengyong Yang Xiaobo Cen Yinglan Zhao Source Type: research

[Retracted] miR ‑363 inhibits the growth, migration and invasion of hepatocellular carcinoma cells by regulating E2F3
Oncol Rep. 2021 Nov;46(5):230. doi: 10.3892/or.2021.8181. Epub 2021 Sep 9.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that tumour images featured in Fig. 2E were strikingly similar to those that had already appeared in different form in another article by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published elsewhere prior to its submission to Oncology Reports, the Editor has decided that this paper should be retracted from the Journal. After having been in contact wit...
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Junfeng Ye Wei Zhang Songyang Liu Yahui Liu Kai Liu Source Type: research

Metastatic pancreatic cancer: Mechanisms and detection (Review)
Oncol Rep. 2021 Nov;46(5):231. doi: 10.3892/or.2021.8182. Epub 2021 Sep 9.ABSTRACTPancreatic cancer (PC) is a lethal malignancy. Its prevalence rate remains low but continues to grow each year. Among all stages of PC, metastatic PC is defined as late‑stage (stage IV) PC and has an even higher fatality rate. Patients with PC do not have any specific clinical manifestations. Most cases are inoperable at the time‑point of diagnosis. Prognosis is also poor even with curative‑intent surgery. Complications during surgery, postoperative pancreatic fistula and recurrence with metastatic foci make the management of metastatic...
Source: Oncology Reports - September 9, 2021 Category: Cancer & Oncology Authors: Xiangling Chen Fangfang Liu Qingping Xue Xiechuan Weng Fan Xu Source Type: research

New insights from Whole Genome Sequencing: BCLAF1 deletion as a structural variant that predisposes cells towards cellular transformation
Oncol Rep. 2021 Oct;46(4):229. doi: 10.3892/or.2021.8180. Epub 2021 Sep 7.ABSTRACTCancer arises from a multi‑step cellular transformation process where some mutations may be inherited, while others are acquired during the process of malignant transformation. Aberrations in the BCL2 associated transcription factor 1 (BCLAF1) gene have previously been identified in patients with cancer and the aim of the present study was to identify structural variants (SVs) and the effects of BCLAF1 gene silencing on cell transformation. Whole‑genome sequencing was performed on DNA isolated from tumour biopsies with a histologically co...
Source: Oncology Reports - September 7, 2021 Category: Cancer & Oncology Authors: Lamech M Mwapagha Vimbaishe Chibanga Hendrina Shipanga M Iqbal Parker Source Type: research

Uncovering the interplay between pH receptors and immune cells: Potential drug targets (Review)
Oncol Rep. 2021 Oct;46(4):228. doi: 10.3892/or.2021.8179. Epub 2021 Sep 3.ABSTRACTExtracellular acidosis is associated with various immunopathological states. The microenvironment of numerous solid tumours and inflammatory responses during acute or chronic infection are all related to a pH range of 5.5‑7.0. The relationship between inflammation and immune escape, cancer metabolism, and immunologic suppression drives researchers to focus on the effects of low pH on diverse components of disease immune monitoring. The potential effect of low extracellular pH on the immune function reveals the importance of pH in inflammato...
Source: Oncology Reports - September 3, 2021 Category: Cancer & Oncology Authors: Lin Cao Tianqiao Huang Xiaohong Chen Weisha Li Xingjiu Yang Wenlong Zhang Mengyuan Li Ran Gao Source Type: research

Gallic acid enhances pirarubicin ‑induced anticancer in living K562 and K562/Dox leukemia cancer cells through cellular energetic state impairment and P‑glycoprotein inhibition
Oncol Rep. 2021 Oct;46(4):227. doi: 10.3892/or.2021.8178. Epub 2021 Sep 3.ABSTRACTLeukemia is a common malignancy affecting humans worldwide. Pirarubicin (Pira) is one of the anticancer agents used for the treatment of leukemia. Although Pira is effective, drug resistance may develop in cancer cells exposed to this drug, whereas the combination of natural products with Pira may help to overcome this problem. The aim of the present study was to focus on the effect of gallic acid (GA) on the anticancer activity of Pira in K562 leukemia cells and K562/doxorubicin (Dox)‑resistant leukemia cells in order to investigate the po...
Source: Oncology Reports - September 3, 2021 Category: Cancer & Oncology Authors: Khin Thenu Aye Sakornniya Wattanapongpitak Benjamaporn Supawat Suchart Kothan Chatchanok Udomtanakunchai Singkome Tima Jie Pan Montree Tungjai Source Type: research

Roles of circRNAs in cancer chemoresistance (Review)
Oncol Rep. 2021 Oct;46(4):225. doi: 10.3892/or.2021.8176. Epub 2021 Sep 1.ABSTRACTCircular RNA (circRNA) is a type of endogenous, high‑stability, noncoding RNA. circRNAs exhibit various biological functions, and are involved in physiological and pathological processes occurring in various diseases, including cancers. They can not only act as microRNA and protein sponges, but also interact with proteins, translated peptides, and transcriptional and translational regulators, and compete with pre‑mRNA splicing. Chemotherapy is one of the most important types of cancer treatment. However, the resistance of cancer cells to ...
Source: Oncology Reports - September 1, 2021 Category: Cancer & Oncology Authors: Chuan Xin Fei Huang Jiongke Wang Jing Li Qianming Chen Source Type: research

Development of patient ‑derived tumor organoids and a drug testing model for renal cell carcinoma
Oncol Rep. 2021 Oct;46(4):226. doi: 10.3892/or.2021.8177. Epub 2021 Sep 1.ABSTRACTThe selection of effective therapeutic agents is critical for improving the survival of patients with renal cell carcinoma (RCC). The aim of the present study was to develop an ex vivo drug testing assay using patient‑derived tumor organoid (TO) cultures. For this purpose, surgical tumor specimens were obtained from 20 patients with RCC. TOs were developed ex vivo from freshly resected RCC tumors, and their histopathological and molecular characteristics were evaluated using histological staining and whole‑exome sequencing (WES). Using a ...
Source: Oncology Reports - September 1, 2021 Category: Cancer & Oncology Authors: Akira Kazama Tsutomu Anraku Hiroo Kuroki Yuko Shirono Masaki Murata Vladimir Bilim Andrey Ugolkov Kazuhide Saito Yoshihiko Tomita Source Type: research

YAP activation attenuates toxicarioside G ‑induced lethal autophagy arrest in SW480 colorectal cancer cells
In conclusion, the findings of the present study indicated that TCG may induce lethal autophagy arrest and activate YAP, which serves a protective role in the SW480 cell line. These results suggested that the combined targeting of TCG and YAP may represent a promising strategy for TCG‑mediated anticancer therapy.PMID:34458926 | DOI:10.3892/or.2021.8175 (Source: Oncology Reports)
Source: Oncology Reports - August 30, 2021 Category: Cancer & Oncology Authors: Limin Zhou Jinyan Wang Jiaqi Liu Jiantang Liang Yansong Wang Qunfang Cai Yonghao Huang Source Type: research

Hormone therapy for ovarian cancer: Emphasis on mechanisms and applications (Review)
Oncol Rep. 2021 Oct;46(4):223. doi: 10.3892/or.2021.8174. Epub 2021 Aug 26.ABSTRACTOvarian cancer (OC) remains the leading cause of mortality due to gynecological malignancies. Epidemiological studies have demonstrated that steroid hormones released from the hypothalamic‑pituitary‑ovarian axis can play a role in stimulating or inhibiting OC progression, with gonadotropins, estrogens and androgens promoting OC progression, while gonadotropin‑releasing hormone (GnRH) and progesterone may be protective factors in OC. Experimental studies have indicated that hormone receptors are expressed in OC cells and mediate the gro...
Source: Oncology Reports - August 26, 2021 Category: Cancer & Oncology Authors: Hongyi Li Yu Liu Yang Wang Xia Zhao Xiaorong Qi Source Type: research

[Retracted] Function of miR ‑212 as a tumor suppressor in thyroid cancer by targeting SIRT1
Oncol Rep. 2021 Oct;46(4):222. doi: 10.3892/or.2021.8173. Epub 2021 Aug 26.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the tumor images shown in Fig. 6B bore unexpected similarities to data appearing in different form in other articles by different authors. In addition, there were potential anomalies associated with the cell migration assay data shown in Fig. 2E. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to On...
Source: Oncology Reports - August 26, 2021 Category: Cancer & Oncology Authors: Dandan Li Lin Bai Tongtong Wang Qian Xie Minglong Chen Yantao Fu Qiang Wen Source Type: research

Hormone therapy for ovarian cancer: Emphasis on mechanisms and applications (Review)
Oncol Rep. 2021 Oct;46(4):223. doi: 10.3892/or.2021.8174. Epub 2021 Aug 26.ABSTRACTOvarian cancer (OC) remains the leading cause of mortality due to gynecological malignancies. Epidemiological studies have demonstrated that steroid hormones released from the hypothalamic‑pituitary‑ovarian axis can play a role in stimulating or inhibiting OC progression, with gonadotropins, estrogens and androgens promoting OC progression, while gonadotropin‑releasing hormone (GnRH) and progesterone may be protective factors in OC. Experimental studies have indicated that hormone receptors are expressed in OC cells and mediate the gro...
Source: Oncology Reports - August 26, 2021 Category: Cancer & Oncology Authors: Hongyi Li Yu Liu Yang Wang Xia Zhao Xiaorong Qi Source Type: research

[Retracted] Function of miR ‑212 as a tumor suppressor in thyroid cancer by targeting SIRT1
Oncol Rep. 2021 Oct;46(4):222. doi: 10.3892/or.2021.8173. Epub 2021 Aug 26.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the tumor images shown in Fig. 6B bore unexpected similarities to data appearing in different form in other articles by different authors. In addition, there were potential anomalies associated with the cell migration assay data shown in Fig. 2E. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to On...
Source: Oncology Reports - August 26, 2021 Category: Cancer & Oncology Authors: Dandan Li Lin Bai Tongtong Wang Qian Xie Minglong Chen Yantao Fu Qiang Wen Source Type: research

Hormone therapy for ovarian cancer: Emphasis on mechanisms and applications (Review)
Oncol Rep. 2021 Oct;46(4):223. doi: 10.3892/or.2021.8174. Epub 2021 Aug 26.ABSTRACTOvarian cancer (OC) remains the leading cause of mortality due to gynecological malignancies. Epidemiological studies have demonstrated that steroid hormones released from the hypothalamic‑pituitary‑ovarian axis can play a role in stimulating or inhibiting OC progression, with gonadotropins, estrogens and androgens promoting OC progression, while gonadotropin‑releasing hormone (GnRH) and progesterone may be protective factors in OC. Experimental studies have indicated that hormone receptors are expressed in OC cells and mediate the gro...
Source: Oncology Reports - August 26, 2021 Category: Cancer & Oncology Authors: Hongyi Li Yu Liu Yang Wang Xia Zhao Xiaorong Qi Source Type: research

[Retracted] Function of miR ‑212 as a tumor suppressor in thyroid cancer by targeting SIRT1
Oncol Rep. 2021 Oct;46(4):222. doi: 10.3892/or.2021.8173. Epub 2021 Aug 26.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the tumor images shown in Fig. 6B bore unexpected similarities to data appearing in different form in other articles by different authors. In addition, there were potential anomalies associated with the cell migration assay data shown in Fig. 2E. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to On...
Source: Oncology Reports - August 26, 2021 Category: Cancer & Oncology Authors: Dandan Li Lin Bai Tongtong Wang Qian Xie Minglong Chen Yantao Fu Qiang Wen Source Type: research

Hormone therapy for ovarian cancer: Emphasis on mechanisms and applications (Review)
Oncol Rep. 2021 Oct;46(4):223. doi: 10.3892/or.2021.8174. Epub 2021 Aug 26.ABSTRACTOvarian cancer (OC) remains the leading cause of mortality due to gynecological malignancies. Epidemiological studies have demonstrated that steroid hormones released from the hypothalamic‑pituitary‑ovarian axis can play a role in stimulating or inhibiting OC progression, with gonadotropins, estrogens and androgens promoting OC progression, while gonadotropin‑releasing hormone (GnRH) and progesterone may be protective factors in OC. Experimental studies have indicated that hormone receptors are expressed in OC cells and mediate the gro...
Source: Oncology Reports - August 26, 2021 Category: Cancer & Oncology Authors: Hongyi Li Yu Liu Yang Wang Xia Zhao Xiaorong Qi Source Type: research

[Retracted] Function of miR ‑212 as a tumor suppressor in thyroid cancer by targeting SIRT1
Oncol Rep. 2021 Oct;46(4):222. doi: 10.3892/or.2021.8173. Epub 2021 Aug 26.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the tumor images shown in Fig. 6B bore unexpected similarities to data appearing in different form in other articles by different authors. In addition, there were potential anomalies associated with the cell migration assay data shown in Fig. 2E. Owing to the fact that some of the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to On...
Source: Oncology Reports - August 26, 2021 Category: Cancer & Oncology Authors: Dandan Li Lin Bai Tongtong Wang Qian Xie Minglong Chen Yantao Fu Qiang Wen Source Type: research

RHPN1 ‑AS1 promotes ovarian carcinogenesis by sponging miR‑6884‑5p thus releasing TOP2A mRNA
Oncol Rep. 2021 Oct;46(4):221. doi: 10.3892/or.2021.8172. Epub 2021 Aug 20.ABSTRACTOvarian cancer, a severe lethal gynecological malignancy, is characterized by both high morbidity and mortality. Long noncoding RNAs (lncRNAs) have recently caused extensive concern due to their regulatory function in various human tumors. There are a mounting number of lncRNAs that are in extreme need of research, serving as biomarkers for diagnosis and therapy for ovarian cancer. In the present study, RT‑qPCR was employed to detect how Rhophilin Rho GTPase binding protein 1 antisense RNA1 (RHPN1‑AS1), miR‑6884‑5p and DNA topoisomer...
Source: Oncology Reports - August 20, 2021 Category: Cancer & Oncology Authors: Shoubin Cui Fengling Li Source Type: research

MicroRNA ‑8063 targets heterogeneous nuclear ribonucleoprotein AB to inhibit the self‑renewal of colorectal cancer stem cells via the Wnt/β‑catenin pathway
Oncol Rep. 2021 Oct;46(4):219. doi: 10.3892/or.2021.8170. Epub 2021 Aug 13.ABSTRACTThe presence of cancer stem cells (CSCs) is a major cause of therapeutic failure in a variety of cancer types, including colorectal cancer (CRC). However, the underlying mechanisms that regulate the self‑renewal of colorectal cancer stem cells (CRCSCs) remain unclear. Our previous study utilized CRCSCs and their parent cells; through gene microarray screening and bioinformatics analysis, we hypothesized that microRNA (miR)‑8063 may bind to, and regulate the expression of, heterogeneous nuclear ribonucleoprotein AB (hnRNPAB) to facilitate...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Zheng-Quan Chen Tao Yuan Hang Jiang Yuan-Yuan Yang Lin Wang Rui-Min Fu Sheng-Qiang Luo Tao Zhang Zhen-Yu Wu Kun-Ming Wen Source Type: research

Ultrasound ‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer
Oncol Rep. 2021 Oct;46(4):220. doi: 10.3892/or.2021.8171. Epub 2021 Aug 13.ABSTRACTUltrasound‑targeted microbubble destruction (UTMD) has recently been developed as a promising noninvasive tool for organ‑ and tissue‑specific gene or drug delivery. The aim of the present study was to explore the role of UTMD‑mediated Sirtuin 3 (SIRT3) overexpression in the malignant behaviors of human ovarian cancer (HOC) cells. Reverse transcription‑quantitative PCR was performed to detect SIRT3 mRNA expression levels in normal human ovarian epithelial cells and HOC cell lines; low SIRT3 expression was found in HOC cell lines, an...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Li Cheng Dongmei Zhang Wei Yan Source Type: research

Knockdown of circNRIP1 sensitizes colorectal cancer to 5 ‑FU via sponging miR‑532‑3p
In conclusion, overexpression of circNRIP1 promoted the progression of CRC, while circNRIP1 silencing sensitized CRC cells to 5‑FU via sponging miR‑532‑3p.PMID:34396434 | DOI:10.3892/or.2021.8169 (Source: Oncology Reports)
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Fanfan Liu Ruijia Li Rui Zhang Meng He Yueli Zhang Source Type: research

Plasma ‑derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells
Oncol Rep. 2021 Oct;46(4):216. doi: 10.3892/or.2021.8167. Epub 2021 Aug 13.ABSTRACTExosomal pyruvate kinase isoenzyme type M2 (PKM2) has been found to play a key role in the progression of human hepatocarcinoma. However, exosomal PKM2 (especially plasma‑derived exosomal PKM2), in patients with oesophageal squamous cell carcinoma (ESCC) has not been well defined. In the present study, plasma‑derived exosomes were isolated from healthy controls and patients with ESCC, and identified by transmission electronic microscopy, western blotting, nano‑flow cytometry, nanoparticle tracking and phagocytosis analysis; exosomal PK...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Lifei Yang Shutao Zheng Qing Liu Tao Liu Qiqi Zhang Xiujuan Han Aerziguli Tuerxun Xiaomei Lu Source Type: research

Comparison of the multigene panel test and OncoScan ™ for the determination of < em > HER2 < /em > amplification in breast cancer
Oncol Rep. 2021 Oct;46(4):217. doi: 10.3892/or.2021.8168. Epub 2021 Aug 13.ABSTRACTThe diagnostic accuracy of the multigene panel test (MPT) and OncoScan™ in the determination of HER2 amplification in breast tumors remains controversial. In the present study, HER2 copy number was analyzed using both MPT and OncoScan™ in 45 breast tumors and was compared with that in fluorescent in situ hybridization (FISH) analysis. Tumors with low cellularity were examined using tumor cell enrichment and fluorescence‑activated cell sorting. Both MPT and OncoScan™ exhibited significant correlations with FISH with respec...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Kaori Akazawa Naofumi Kagara Yoshiaki Sota Daisuke Motooka Shota Nakamura Tomohiro Miyake Tomonori Tanei Yasuto Naoi Masafumi Shimoda Seung Jin Kim Shinzaburo Noguchi Kenzo Shimazu Source Type: research

Targeting USP22 with miR ‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells
In this study, it was predicted that ubiquitin‑specific peptidase 22 (USP22) is the direct target of the microRNA (miR)‑30‑5p family, including miR‑30a‑5p, miR‑30b‑5p, miR‑30c‑5p, miR‑30d‑5p and miR‑30e‑5p. Furthermore, the binding of USP22 with the miR‑30‑5p family was confirmed by luciferase assay. In addition, it was demonstrated that targeting USP22 via the miR‑30‑5p family inhibited the induction of PD‑L1 expression in hypoxic conditions, thus preventing activated T cells from killing LUAD cells. Our results indicated that miR‑30a‑5p, miR‑30b‑5p, miR‑30c‑5p, miR‑30d‑...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Xiaoyang Hua Heng Chu Chuanxiao Wang Xuexin Shi Ailin Wang Zhe Zhang Source Type: research

MicroRNA ‑8063 targets heterogeneous nuclear ribonucleoprotein AB to inhibit the self‑renewal of colorectal cancer stem cells via the Wnt/β‑catenin pathway
Oncol Rep. 2021 Oct;46(4):219. doi: 10.3892/or.2021.8170. Epub 2021 Aug 13.ABSTRACTThe presence of cancer stem cells (CSCs) is a major cause of therapeutic failure in a variety of cancer types, including colorectal cancer (CRC). However, the underlying mechanisms that regulate the self‑renewal of colorectal cancer stem cells (CRCSCs) remain unclear. Our previous study utilized CRCSCs and their parent cells; through gene microarray screening and bioinformatics analysis, we hypothesized that microRNA (miR)‑8063 may bind to, and regulate the expression of, heterogeneous nuclear ribonucleoprotein AB (hnRNPAB) to facilitate...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Zheng-Quan Chen Tao Yuan Hang Jiang Yuan-Yuan Yang Lin Wang Rui-Min Fu Sheng-Qiang Luo Tao Zhang Zhen-Yu Wu Kun-Ming Wen Source Type: research

Ultrasound ‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer
Oncol Rep. 2021 Oct;46(4):220. doi: 10.3892/or.2021.8171. Epub 2021 Aug 13.ABSTRACTUltrasound‑targeted microbubble destruction (UTMD) has recently been developed as a promising noninvasive tool for organ‑ and tissue‑specific gene or drug delivery. The aim of the present study was to explore the role of UTMD‑mediated Sirtuin 3 (SIRT3) overexpression in the malignant behaviors of human ovarian cancer (HOC) cells. Reverse transcription‑quantitative PCR was performed to detect SIRT3 mRNA expression levels in normal human ovarian epithelial cells and HOC cell lines; low SIRT3 expression was found in HOC cell lines, an...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Li Cheng Dongmei Zhang Wei Yan Source Type: research

Knockdown of circNRIP1 sensitizes colorectal cancer to 5 ‑FU via sponging miR‑532‑3p
In conclusion, overexpression of circNRIP1 promoted the progression of CRC, while circNRIP1 silencing sensitized CRC cells to 5‑FU via sponging miR‑532‑3p.PMID:34396434 | DOI:10.3892/or.2021.8169 (Source: Oncology Reports)
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Fanfan Liu Ruijia Li Rui Zhang Meng He Yueli Zhang Source Type: research

Plasma ‑derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells
Oncol Rep. 2021 Oct;46(4):216. doi: 10.3892/or.2021.8167. Epub 2021 Aug 13.ABSTRACTExosomal pyruvate kinase isoenzyme type M2 (PKM2) has been found to play a key role in the progression of human hepatocarcinoma. However, exosomal PKM2 (especially plasma‑derived exosomal PKM2), in patients with oesophageal squamous cell carcinoma (ESCC) has not been well defined. In the present study, plasma‑derived exosomes were isolated from healthy controls and patients with ESCC, and identified by transmission electronic microscopy, western blotting, nano‑flow cytometry, nanoparticle tracking and phagocytosis analysis; exosomal PK...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Lifei Yang Shutao Zheng Qing Liu Tao Liu Qiqi Zhang Xiujuan Han Aerziguli Tuerxun Xiaomei Lu Source Type: research

Comparison of the multigene panel test and OncoScan ™ for the determination of < em > HER2 < /em > amplification in breast cancer
Oncol Rep. 2021 Oct;46(4):217. doi: 10.3892/or.2021.8168. Epub 2021 Aug 13.ABSTRACTThe diagnostic accuracy of the multigene panel test (MPT) and OncoScan™ in the determination of HER2 amplification in breast tumors remains controversial. In the present study, HER2 copy number was analyzed using both MPT and OncoScan™ in 45 breast tumors and was compared with that in fluorescent in situ hybridization (FISH) analysis. Tumors with low cellularity were examined using tumor cell enrichment and fluorescence‑activated cell sorting. Both MPT and OncoScan™ exhibited significant correlations with FISH with respec...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Kaori Akazawa Naofumi Kagara Yoshiaki Sota Daisuke Motooka Shota Nakamura Tomohiro Miyake Tomonori Tanei Yasuto Naoi Masafumi Shimoda Seung Jin Kim Shinzaburo Noguchi Kenzo Shimazu Source Type: research

Targeting USP22 with miR ‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells
In this study, it was predicted that ubiquitin‑specific peptidase 22 (USP22) is the direct target of the microRNA (miR)‑30‑5p family, including miR‑30a‑5p, miR‑30b‑5p, miR‑30c‑5p, miR‑30d‑5p and miR‑30e‑5p. Furthermore, the binding of USP22 with the miR‑30‑5p family was confirmed by luciferase assay. In addition, it was demonstrated that targeting USP22 via the miR‑30‑5p family inhibited the induction of PD‑L1 expression in hypoxic conditions, thus preventing activated T cells from killing LUAD cells. Our results indicated that miR‑30a‑5p, miR‑30b‑5p, miR‑30c‑5p, miR‑30d‑...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Xiaoyang Hua Heng Chu Chuanxiao Wang Xuexin Shi Ailin Wang Zhe Zhang Source Type: research

MicroRNA ‑8063 targets heterogeneous nuclear ribonucleoprotein AB to inhibit the self‑renewal of colorectal cancer stem cells via the Wnt/β‑catenin pathway
Oncol Rep. 2021 Oct;46(4):219. doi: 10.3892/or.2021.8170. Epub 2021 Aug 13.ABSTRACTThe presence of cancer stem cells (CSCs) is a major cause of therapeutic failure in a variety of cancer types, including colorectal cancer (CRC). However, the underlying mechanisms that regulate the self‑renewal of colorectal cancer stem cells (CRCSCs) remain unclear. Our previous study utilized CRCSCs and their parent cells; through gene microarray screening and bioinformatics analysis, we hypothesized that microRNA (miR)‑8063 may bind to, and regulate the expression of, heterogeneous nuclear ribonucleoprotein AB (hnRNPAB) to facilitate...
Source: Oncology Reports - August 16, 2021 Category: Cancer & Oncology Authors: Zheng-Quan Chen Tao Yuan Hang Jiang Yuan-Yuan Yang Lin Wang Rui-Min Fu Sheng-Qiang Luo Tao Zhang Zhen-Yu Wu Kun-Ming Wen Source Type: research