CX3CL1 promotes lung cancer cell migration and invasion via the Src/focal adhesion kinase signaling pathway.
Authors: Liu W, Liang Y, Chan Q, Jiang L, Dong J Abstract The present study investigated the role of C‑X3‑C motif chemokine ligand 1 (CX3CL1) in lung cancer cell migration and invasion and its potential mechanism. The expression levels of C‑X3‑C motif chemokine receptor 1 (CX3CR1) in six human lung cancer cell lines and one human bronchial epithelial cell line were assessed using reverse transcription‑quantitative polymerase chain reaction and western blotting. Cell proliferation was assessed using the Cell Counting Kit‑8 assay. Cell migration and invasion were examined using the Transwell assay, with a...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Intravesical treatment of chemotherapeutic agents sensitizes bacillus Calmette ‑Guerin by the modulation of the tumor immune environment.
Intravesical treatment of chemotherapeutic agents sensitizes bacillus Calmette‑Guerin by the modulation of the tumor immune environment. Oncol Rep. 2019 Jan 10;: Authors: Hori S, Miyake M, Tatsumi Y, Morizawa Y, Nakai Y, Onishi S, Onishi K, Iida K, Gotoh D, Itami Y, Tanaka N, Fujimoto K Abstract Intravesical treatment with bacillus Calmette‑Guerin (BCG) is the most common treatment for preventing progression and recurrence of non‑muscle invasive bladder cancer. Our previous study using the N‑butyl‑N‑(4‑hydroxybutyl) nitrosamine (BBN)‑induced orthotopic bladder cancer model demonstrated ...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of NELL1 on lung cancer stem ‑like cell differentiation.
Effect of NELL1 on lung cancer stem‑like cell differentiation. Oncol Rep. 2019 Jan 03;: Authors: Zhai Y, Wei R, Sha S, Lin C, Wang H, Jiang X, Liu G Abstract The cancer stem cell theory recently has received enormous attention in cancer biology. Lung cancer stem‑like cells are a subpopulation of undifferentiated lung tumor cells critical for lung cancer tumorigenesis, metastasis and resistance to therapy and disease relapse. The neural EGFL like 1 (NELL1) is a potent growth factor believed to preferentially target cells committed to the osteochondral lineage; yet, its expression and function i...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ubiquitination ‑deubiquitination in the Hippo signaling pathway (Review).
Ubiquitination‑deubiquitination in the Hippo signaling pathway (Review). Oncol Rep. 2019 Jan 08;: Authors: Liu Y, Deng J Abstract The Hippo signaling pathway is considered to be a tissue growth regulator and tumor suppressor pathway that controls cell proliferation, differentiation, survival, regeneration and tissue homeostasis. Defects in Hippo kinases and hyperactivation of transcriptional co‑activator with PDZ‑binding motif and Yes‑associated protein (YAP) may contribute to the development of different types of cancer. The Hippo pathway is regulated in a variety of way, of which ubiquitinati...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Oncogenic function of Plac1 on the proliferation and metastasis in hepatocellular carcinoma cells.
Authors: Wu Y, Lin X, Di X, Chen Y, Zhao H, Wang X Abstract Following the publication of this article, the authors have realized that Table I contained some important errors. The data shown for the positive or negative HBsAg patient characteristic in terms of the no. of patients, Plac1 (+) and Plac1 (‑) were incorrect. A corrected version of the Table is shown below (the corrected data are highlighted in bold). The authors sincerely apologize for the errors that were introduced during the preparation of this Table. Furthermore, they regret any inconvenience that this mistake has caused. [the original ar...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer (Review).
Authors: Hu M, Zhu S, Xiong S, Xue X, Zhou X Abstract Gastric carcinogenesis arises from complicated interactions among host, environmental and bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor‑suppressive genes. MicroRNAs (miRNAs), a class of small non‑coding RNAs that post‑transcriptionally regulate ~30% human genes, may serve as oncogenes or tumor‑suppressors in malignancies, including gastric cancer (GC). Although miRNA dysregulation commonly exists in GC, exact roles miRNAs serve in the pathogenesis and promotion of this tumor remain undetermined. Recently, resu...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer.
In conclusion, the findings of the present study demonstrated that high‑dose MTX enhanced anticancer activity in α‑TOS‑treated TNBC, while low‑dose MTX reduced anticancer activity in α‑TOS‑treated TNBC. PMID: 30628707 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy.
Authors: Wang X, Liao X, Yang C, Huang K, Yu T, Yu L, Han C, Zhu G, Zeng X, Liu Z, Zhou X, Qin W, Su H, Ye X, Peng T Abstract Hepatocellular carcinoma (HCC) is a lethal malignancy with high morbidity and mortality rates worldwide. The identification of prognosis‑associated biomarkers is crucial to improve HCC patient survival. The present study aimed to explore potential predictive biomarkers for HCC. Differentially expressed genes (DEGs) were analyzed in the GSE36376 dataset using GEO2R. Hub genes were identified and further investigated for prognostic value in HCC patients. A risk score model and nomogram were ...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Electrochemotherapy of radioresistant head and neck squamous cell carcinoma cells and tumor xenografts.
Authors: Zakelj MN, Prevc A, Kranjc S, Cemazar M, Todorovic V, Savarin M, Scancar J, Kosjek T, Groselj B, Strojan P, Sersa G Abstract Electrochemotherapy is an established local ablative method used for the treatment of different tumor types, including tumors of the head and neck area. Clinical studies have demonstrated a lower response rate of tumors that recur in pre‑irradiated area. The aim of the present study was to explore the response of experimentally induced radioresistant cells and tumors to electrochemotherapy with cisplatin or bleomycin. The radioresistant cells (FaDu‑RR) were established by fractio...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway.
Authors: Zheng M, Zhou Q, Liu X, Wang C, Liu G Abstract The tumorigenesis and metastasis of tumors are associated with human collagen triple helix repeats containing 1 (CTHRC1). To study the effects and possible impacting mechanisms of CTHRC1 on human cervical carcinoma development, samples of paraffin‑embedded cervical carcinoma and HeLa cells were examined. Immunofluorescence, cell wound scratch assay, western blot analysis and Transwell invasion assay were used to evaluate HeLa cells in response to silencing of the CTHRC1 gene in cervical carcinoma. The expression levels of gap‑associated proteins of the Wnt...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4.
miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncol Rep. 2019 Jan 09;: Authors: Zheng Y, Pan C, Chen M, Pei A, Xie L, Zhu S Abstract Ischemic stroke is the main cause of brain injury and results in a high rate of morbidity, disability and mortality. In the present study, we aimed to determine whether miR‑29a played a protective role in oxygen glucose deprivation (OGD) injury via regulation of the water channel protein aquaporin 4 (AQP4). Real‑time PCR and western blotting were used to assess miR‑29a levels and AQP4 protein levels,...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Introduction of exogenous wild ‑type p53 mediates the regulation of oncoprotein 18/stathmin signaling via nuclear factor‑κB in non‑small cell lung cancer NCI‑H1299 cells.
Introduction of exogenous wild‑type p53 mediates the regulation of oncoprotein 18/stathmin signaling via nuclear factor‑κB in non‑small cell lung cancer NCI‑H1299 cells. Oncol Rep. 2019 Jan 10;: Authors: Chen S, Zhao Y, Shen F, Long D, Yu T, Lin X Abstract Our previous studies demonstrated that high expression of oncoprotein 18 (Op18)/stathmin promotes malignant transformation of non‑small cell lung cancer NCI‑H1299 cells. Investigation of the cellular settings determined that NCI‑H1299 cells were genetically p53 deficient. In order to determine whether p53 deficiency is associ...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

XPC inhibition rescues cisplatin resistance via the Akt/mTOR signaling pathway in A549/DDP lung adenocarcinoma cells.
Authors: Teng X, Fan XF, Li Q, Liu S, Wu DY, Wang SY, Shi Y, Dong M Abstract Xeroderma pigmentosum, complementation group C (XPC) is an accessory recognition gene involved in the nucleotide excision repair (NER) pathway, which is activated during the initial DNA damage recognition stage. It participates in the regulation of DNA damage‑induced proliferation and apoptosis. Emerging evidence demonstrates that upregulation of XPC increases the resistance of several tumor cell types to cytotoxic drugs. In addition, it can predict poor patient outcome for non‑small cell lung cancer (NSCLC). However, the mechanisms li...
Source: Oncology Reports - January 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification and validation of alternative splicing isoforms as novel biomarker candidates in hepatocellular carcinoma.
In conclusion, the findings of the three AS candidates in the present study could be beneficial in HCC prognosis and new treatment strategies. PMID: 30592283 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 31, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gambogenic acid inhibits the proliferation of small ‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis.
Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis. Oncol Rep. 2018 Dec 21;: Authors: Huang T, Zhang H, Wang X, Xu L, Jia J, Zhu X Abstract Gambogenic acid (GNA), which is an important active compound present in gamboge, exerts anticancer activity in various types of tumor cells. However, the effect of GNA on small‑cell lung cancer (SCLC) cell lines and the underlying mechanism involved still remain unclear. In the present study, GNA inhibited the proliferation and cell cycle progression of SCLC cells. GNA also promoted the ...
Source: Oncology Reports - December 31, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑498 inhibits the growth and metastasis of liver cancer by targeting ZEB2.
miR‑498 inhibits the growth and metastasis of liver cancer by targeting ZEB2. Oncol Rep. 2018 Dec 21;: Authors: Zhang X, Xu X, Ge G, Zang X, Shao M, Zou S, Zhang Y, Mao Z, Zhang J, Mao F, Qian H, Xu W Abstract MicroRNAs (miRNAs) play critical roles in the growth, metastasis and therapeutic resistance of liver cancer. Accumulating evidence suggests that miR‑498 is aberrantly expressed in several human malignancies. However, the role and underlying mechanism of miR‑498 in liver cancer remain unclear. In the present study, we investigated the potential roles and clinical value of miR‑498 in liver ...
Source: Oncology Reports - December 31, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Integrating modern approaches to pathogenetic concepts of malignant transformation of endometriosis.
Authors: Kobayashi H, Yamada Y, Kawahara N, Ogawa K, Yoshimoto C Abstract In the present study, we summarize the role of the shared and independent (epi)genetic background between endometrioid carcinoma (EC) and clear cell carcinoma (CCC), two histological subtypes of endometriosis-associated ovarian cancer (EAOC). Using the PubMed database, we conducted a literature review of various studies related to the malignant transformation of endometriosis. Both endometriosis and EAOC face potential environmental hazards, including hemoglobin (Hb), heme and free iron, which induces DNA damage and mutations. Although EC is ...
Source: Oncology Reports - December 31, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SHCBP1 is a novel target and exhibits tumor ‑promoting effects in gastric cancer.
SHCBP1 is a novel target and exhibits tumor‑promoting effects in gastric cancer. Oncol Rep. 2018 Dec 21;: Authors: Dong YD, Yuan YL, Yu HB, Tian GJ, Li DY Abstract The present study investigated the expression and potential influence of SHC SH2 domain‑binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in GC tissues. Furthermore, SHCBP1 was revealed to be highly expressed in GC cell lines MGC‑803 and SGC‑7901 cells, ...
Source: Oncology Reports - December 31, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cytoplasmic M ‑CSF facilitates apoptosis resistance by inhibiting the HIF‑1α/BNIP3/Bax signalling pathway in MCF‑7 cells.
In conclusion, cytoplasmic M‑CSF suppressed apoptosis by inhibiting the HIF‑1α/BNIP3/Bax signalling pathway, which potentiated the dissociation of Bcl‑2 from Bcl‑2‑BNIP3 compounds and the formation of Bcl‑2‑Bax compounds. PMID: 30592292 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 31, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Bromodomain ‑containing protein 7 sensitizes breast cancer cells to paclitaxel by activating Bcl2‑antagonist/killer protein.
Bromodomain‑containing protein 7 sensitizes breast cancer cells to paclitaxel by activating Bcl2‑antagonist/killer protein. Oncol Rep. 2018 Dec 21;: Authors: Ma J, Niu W, Wang X, Zhou Y, Wang H, Liu F, Liu Y, Guo J, Xiong W, Zeng Z, Fan S, Li X, Nie X, Li G, Gui R, Luo Y, Zhou M Abstract Our previous study demonstrated that bromodomain‑containing protein 7 (BRD7) inhibits cell proliferation and tumor growth, restoring the expression of B‑cell lymphoma 2 antagonist/killer (Bak) sensitized breast cancer cells to paclitaxel. However, the association between BRD7 and paclitaxel sensi...
Source: Oncology Reports - December 31, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer.
Authors: Guo L, Ma L, Liu C, Lei Y, Tang N, Huang Y, Huang G, Li D, Wang Q, Liu G, Tang M, Jing Z, Deng Y Abstract Endoplasmic reticulum protein 29 (ERp29), an endoplasmic reticulum (ER) protein, participates in ER stress (ERS), but little is known about the association of ERp29 with ERS in the metastasis and prognosis of cancerous diseases. The present study revealed that ERp29 was important to ERS and interfered with the malignant behaviors of colorectal cancer (CRC). Experiments in in vitro and in animal models revealed that ERS inhibited the cell growth and suppressed the metastatic capacity of C...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑107‑5p promotes tumor proliferation and invasion by targeting estrogen receptor‑α in endometrial carcinoma.
In conclusion, our results highlighted that miR‑107‑5p is a novel prognostic factor that targets ERα to promote tumor proliferation and invasion of EC. PMID: 30569100 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Imatinib ‑induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress.
Imatinib‑induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress. Oncol Rep. 2018 Dec 19;: Authors: Kim JL, Lee DH, Jeong S, Kim BR, Na YJ, Park SH, Jo MJ, Jeong YA, Oh SC Abstract Imatinib is a powerful tyrosine kinase inhibitor that specifically targets BCR‑ABL, c‑KIT, and PDGFR kinases, and is used in the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumors, and other types of cancers. However, the possible anticancer effects of imatinib in gastric cancer have not yet been explored. The present study evaluated the in vitro effects of ima...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Early decrease in serum amphiregulin or vascular endothelial growth factor levels predicts sorafenib efficacy in hepatocellular carcinoma.
Authors: Godin C, Bodeau S, Saidak Z, Louandre C, François C, Barbare JC, Coriat R, Galmiche A, Sauzay C Abstract Sorafenib is the standard of care for the treatment of advanced hepatocellular carcinoma (HCC). However, identifying secreted biomarkers that predict sorafenib efficacy in all HCC patients remains challenging. It was recently reported that sorafenib interferes with protein homeostasis and inhibits global translation in tumour cells. A likely consequence of this inhibition would be the interruption of autocrine loops. The aim of the present study was to investigate the effect of sorafenib on two g...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PTEN downregulates WD repeat ‑containing protein 66 in salivary adenoid cystic carcinoma.
PTEN downregulates WD repeat‑containing protein 66 in salivary adenoid cystic carcinoma. Oncol Rep. 2018 Dec 13;: Authors: Cao Y, Liu H, Xia SL, Zhang X, Bai H, Yang Q, Li J, Gao L, Jin F, Wei MJ, Lu SL, Xiao J Abstract Salivary adenoid cystic carcinoma (SACC) is one of the most common types of salivary gland cancer that causes substantial morbidity and mortality. Despite the substantial health burden of SACC, the molecular mechanisms underlying its development and progression remain poorly understood. We previously reported the loss of phosphatase and tensin homolog (PTEN) expression to be comm...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of PIKfyve using YM201636 suppresses the growth of liver cancer via the induction of autophagy.
Authors: Hou JZ, Xi ZQ, Niu J, Li W, Wang X, Liang C, Sun H, Fang D, Xie SQ Abstract Liver cancer is among the most common types of cancer worldwide. The aim of the present study was to investigate whether the phosphatidylinositol‑3‑phosphate 5‑kinase (PIKfyve) inhibitor, YM201636, exerts anti‑proliferative effects on liver cancer. The methods used in the present study included MTT assay, flow cytometry, western blot analysis and an allograft mouse model of liver cancer. The results revealed that YM201636 inhibited the proliferation of HepG2 and Huh‑7 cells in a dose‑dependent manner. HepG2 and Huh...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PEA ‑15 contributes to the clinicopathology and AKT‑regulated cisplatin resistance in gastric cancer.
PEA‑15 contributes to the clinicopathology and AKT‑regulated cisplatin resistance in gastric cancer. Oncol Rep. 2018 Dec 18;: Authors: Jiang X, Zhang C, Li W, Jiang D, Wei Z, Lv M, Xie X, Sun X Abstract Phosphoprotein enriched in astrocytes 15 (PEA‑15) plays an important role in controlling biological behaviors of cancer cells. In the present study, we demonstrated that PEA‑15 was overexpressed in gastric cancer tissues and associated with tumor staging, differentiation, pathological types and the prognosis of patients. Gastric cancer cells expressed variable levels of PEA‑15 and its bi‑pho...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The role of ZBTB38 in promoting migration and invasive growth of bladder cancer cells.
Authors: Jing J, Liu J, Wang Y, Zhang M, Yang L, Shi F, Liu P, She J Abstract Bladder cancer is the most common malignancy of the urinary tract, and ~50% of patients with bladder cancer experience recurrence and metastasis. The results of mass spectrometry revealed that the expression of zinc finger and BTB domain‑containing 38 (ZBTB38) was higher in highly aggressive human bladder cancer 253J B‑V cells compared with in the less aggressive bladder cancer 253J cells. However, the association between ZBTB38 and bladder cancer is currently not well defined, and the association of ZBTB38 with migration and inv...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Disruption of MAPK1 expression in the ERK signalling pathway and the RUNX1 ‑RUNX1T1 fusion gene attenuate the differentiation and proliferation and induces the growth arrest in t(8;21) leukaemia cells.
Disruption of MAPK1 expression in the ERK signalling pathway and the RUNX1‑RUNX1T1 fusion gene attenuate the differentiation and proliferation and induces the growth arrest in t(8;21) leukaemia cells. Oncol Rep. 2018 Dec 12;: Authors: Bashanfer SAA, Saleem M, Heidenreich O, Moses EJ, Yusoff NM Abstract The t(8;21) translocation is one of the most frequent chromosome abnormalities associated with acute myeloid leukaemia (AML). This abberation deregulates numerous molecular pathways including the ERK signalling pathway among others. Therefore, the aim of the present study was to investigate the gene ex...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Chitosan-coated liposomes loaded with butyric acid demonstrate anticancer and anti-inflammatory activity in human hepatoma HepG2 cells.
Authors: Quagliariello V, Masarone M, Armenia E, Giudice A, Barbarisi M, Caraglia M, Barbarisi A, Persico M Abstract Butyric acid (BA) has been reported to induce anticancer effects on hepatocellular carcinoma (HCC) cells both in vitro and in vivo. However, its delivery and release in cancer tissues must be optimized. On the basis of these requirements, we prepared liposomes coated with chitosan and uncoated liposomes and both types were loaded with BA through a thin-film hydration method. The liposomes coated or uncoated with chitosan had a mean hydrodynamic size of 83.5 and 110.3 nm, respectively, ...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Biological characterisation and application of human MTH1 and monoclonal antibody preparation.
Authors: Chen C, Li X, Gu M, Di R, Kang N, Wang L, Lai Y, Liu Y, Ji X Abstract Human MutT homolog 1 (MTH1) hydrolyses oxidised nucleotide triphosphates, thereby preventing them from being incorporated into DNA; MTH1 has been found to be elevated in many types of cancers, including lung, stomach cancer, melanoma and breast cancer. Thus, tumour‑targeted hMTH1 may be valuable for developing novel anticancer therapies. In the present study, we prepared human MTH1 protein and its monoclonal antibody (mAb). The hMTH1 gene was cloned into the prokaryotic expression vector pET28a and optimally expressed in the E.&nb...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer.
Authors: Ryu TY, Kim K, Son MY, Min JK, Kim J, Han TS, Kim DS, Cho HS Abstract The microbiota and bacterial metabolites in the colon are regarded as alternative targets for colon cancer prevention and therapy. Among these metabolites, short-chain fatty acids (SCFAs) exhibit anticancer effects and suppress inflammation in the colon. However, the molecular mechanisms and target development of SCFAs require additional study. In the present study, using RNA-seq results from colon cancer samples derived from the Cancer Genome Atlas (TCGA) portal, overexpressed epigenetic modifiers were identified and RT-PCR and qRT-PCR ...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑21 regulates the biological behavior of esophageal squamous cell carcinoma by targeting RASA1.
In conclusion, miR‑21 regulated cell proliferation, migration, invasion and tumor growth of ESCC by directly targeting RASA1, which may have been achieved via regulation of Snail and vimentin. Anti‑miR‑21 revealed an antitumor effect. Thus, it may be considered as a possible target for ESCC therapy. PMID: 30569149 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulation of USP11 promotes epithelial ‑to‑mesenchymal transition by deubiquitinating Snail in ovarian cancer.
Upregulation of USP11 promotes epithelial‑to‑mesenchymal transition by deubiquitinating Snail in ovarian cancer. Oncol Rep. 2018 Dec 12;: Authors: Wang W, Wang J, Yan H, Zhang K, Liu Y Abstract Ubiquitin specific peptidase 11 (USP11) is a deubiquitinating enzyme (DUB) and has been observed to promote mammary tumor initiation and progression. Several reports have shown that USP11 plays an important role in cancer development. Previous research has shown that USP11 is upregulated in breast cancer, but the function of USP11 in ovarian cancer has not been determined to date. In the present study, ...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA CASC2/miR ‑18a‑5p axis regulates the malignant potential of nasopharyngeal carcinoma by targeting RBBP8.
lncRNA CASC2/miR‑18a‑5p axis regulates the malignant potential of nasopharyngeal carcinoma by targeting RBBP8. Oncol Rep. 2018 Dec 19;: Authors: Miao WJ, Yuan DJ, Zhang GZ, Liu Q, Ma HM, Jin QQ Abstract Nasopharyngeal carcinoma (NPC) is a prevalent head and neck tumor which has a high mortality rate in Southeast Asia, especially in Southern China. Cancer susceptibility candidate 2 (CASC2) is a newly identified long non‑coding RNA (lncRNA) that has been found to play a suppressive role in several types of tumors. However, the expression and functional role of CASC2 in NPC are still ...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Kenalog modified by ionizing radiation induces intrinsic apoptosis mediated by elevated levels of reactive oxygen species in melanoma cancer.
Authors: Kawala RA, Ramadhani FJ, Choi HJ, Lee EH, Park CH, Chung BY, Bai HW Abstract Kenalog is a synthetic glucocorticoid drug used to treat various cancers including ocular and choroidal melanoma. However, the drug achieves rarely sustainable results for patients. To overcome this difficulty, the structure of Kenalog was altered by ionizing radiation (IR) to develop a more effective anticancer agent for treatment of various skin cancers. The anticancer effect of modified Kenalog (Kenalog‑IR) was assessed in melanoma cancer cells in vitro. The assessment of mitochondrial functions by MTT assay revealed sig...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] High expression of RELM- α correlates with poor prognosis and promotes angiogenesis in gastric cancer.
[Corrigendum] High expression of RELM-α correlates with poor prognosis and promotes angiogenesis in gastric cancer. Oncol Rep. 2018 Dec 17;: Authors: Chen P, Zhao D, Wang W, Zhang Y, Yuan Y, Wang L, Wu Y Abstract Following the publication of the above article, the authors have drawn to our attention that, in Fig. 6 on p. 83, the 'Ad5/F‑35 vector' and 'Control' experiment data panels for the MKN45 cell line were inadvertently derived from the same original source. The Ad5/F35‑vector and Control groups were both negative controls; Ad5/F35‑vector was the empty vector condition, where...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑486‑5p functions as a tumor suppressor of proliferation and cancer stem‑like cell properties by targeting Sirt1 in liver cancer.
MicroRNA‑486‑5p functions as a tumor suppressor of proliferation and cancer stem‑like cell properties by targeting Sirt1 in liver cancer. Oncol Rep. 2018 Dec 13;: Authors: Yan X, Liu X, Wang Z, Cheng Q, Ji G, Yang H, Wan L, Ge C, Zeng Q, Huang H, Xi J, He L, Nan X, Yue W, Pei X Abstract Cancer stem‑like cells (CSCs) are critical for the initiation, progression, chemoresistance and postsurgical recurrence of liver cancer. They are thought to be novel targets for the treatment of liver cancer, however, efficient agents that target liver cancer stem cells (CSCs) have not been identified. MicroRNAs...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SOCS4 expressed by recombinant HSV protects against cytokine storm in a mouse model.
Authors: Ren S, Chen X, Huang R, Zhou GG, Yuan Z Abstract Oncolytic viruses are genetically engineered viruses designed for the treatment of solid tumors, and are often coupled with the antitumor immunity of the host. The challenge of using oncolytic herpes simplex virus (oHSV) as an efficacious oncolytic agent is the potential host tissue damage caused by the production of a range of cytokines following intratumoral oHSV injection. An HSV‑suppressor of cytokine signaling 4 (SOCS4) recombinant virus was created to investigate whether it inhibits cytokine storm. Recombinant HSV‑SOCS4 and HSV‑1(F) were used to ...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression.
Authors: Zhang X, Yang X, Zhu S, Li Q, Zou N Abstract Radiotherapy (RT) is a traditional and important treatment for carcinoma of the esophagus along with surgery and chemotherapy. High mobility group box 1 (HMGB1) plays a crucial part in inhibiting the apoptosis of cancer cells after irradiation treatment. The present study, was designed to analyze the function of HMGB1 in esophageal cancer progression and elucidate the effects of HMGB1 on the radiosensitivity of human esophageal cancer cell lines. In the present study, an immunohistochemical evaluation of HMGB1 was performed on 77 biopsies, and the results reveal...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Distinctive clinicopathological features and disease ‑specific survival of adenoid cystic carcinoma and adenoid basal carcinoma in the lower female genital tract.
Distinctive clinicopathological features and disease‑specific survival of adenoid cystic carcinoma and adenoid basal carcinoma in the lower female genital tract. Oncol Rep. 2018 Dec 12;: Authors: Xing D, Lu J Abstract Adenoid cystic carcinomas (ACCs) and adenoid basal carcinomas (ABCs) in the lower female genital tract are very rare. Data on the clinicopathologic features and survival outcomes of ACCs and ABCs in the lower female genital tract are limited to case reports and small case series studies. The present study systemically analyzed 233 cases, including 84 cervical ACCs, 78 cervical ABCs and ...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Pilot investigation of the mutation profile of PIK3CA/PTEN genes (PI3K pathway) in grade 3 endometrial cancer.
Authors: Malentacchi F, Turrini I, Sorbi F, Projetto E, Castiglione F, Fambrini M, Petraglia F, Pillozzi S, Noci I Abstract Endometrial cancer (EC) comprises a biological and clinical heterogeneous group of tumors. Several genetic alterations are involved in the development and progression of EC, and may be used for targeted therapy, particularly in patients with advanced‑stage EC. In the present study, a combined procedure was developed based on polymerase chain reaction (PCR)‑high resolution melting analysis (HRMA) and Sanger sequencing for the evaluation of somatic mutations in selected phosphoinositide 3‑...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑200a suppresses migration and invasion and enhances the radiosensitivity of NSCLC cells by inhibiting the HGF/c‑Met signaling pathway.
MicroRNA‑200a suppresses migration and invasion and enhances the radiosensitivity of NSCLC cells by inhibiting the HGF/c‑Met signaling pathway. Oncol Rep. 2018 Dec 12;: Authors: Du M, Wang J, Chen H, Wang S, Chen L, Xu Y, Su F, Lu X Abstract Hepatocyte growth factor (HGF), an activator of the c‑Met signaling pathway, is involved in tumor invasiveness, metastasis and radiotherapy resistance. In the present study, a novel HGF regulatory pathway in lung cancer involving micro-RNAs (miRNAs/miR) is described. Immunohistochemical staining and western blot analyses demonstrated that HGF was upregulated ...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The HIF ‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced protective autophagy in glioblastoma and astrocytoma.
The HIF‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced protective autophagy in glioblastoma and astrocytoma. Oncol Rep. 2018 Dec 13;: Authors: Huang S, Qi P, Zhang T, Li F, He X Abstract Human glioblastoma is a malignant and aggressive primary human brain solid tumor characterized by severe hypoxia. Hypoxia can induce autophagy, which may result in chemoresistance and malignant progression of cancer cells. MicroRNAs (miRNAs) have been reported to modulate hypoxia‑induced autophagy in various types of cancers. In the present study, we obs...
Source: Oncology Reports - December 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Novel three ‑lncRNA signature predicts survival in patients with pancreatic cancer.
Novel three‑lncRNA signature predicts survival in patients with pancreatic cancer. Oncol Rep. 2018 Oct 03;: Authors: Wu B, Wang K, Fei J, Bao Y, Wang X, Song Z, Chen F, Gao J, Zhong Z Abstract A growing body of evidence confirms that long non‑coding RNAs (lncRNAs) have an important role in biological processes by regulating gene expression at multiple levels. Dysregulated lncRNAs may be potential prognostic biomarkers or targets for the development of cancer treatments. However, the prognostic role of an lncRNA signature in pancreatic cancer has not been investigated. Pancreatic cancer lncRNA expre...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Bromodomain PHD ‑finger transcription factor promotes glioma progression and indicates poor prognosis.
Bromodomain PHD‑finger transcription factor promotes glioma progression and indicates poor prognosis. Oncol Rep. 2018 Oct 30;: Authors: Pan Y, Yuan F, Li Y, Wang G, Lin Z, Chen L Abstract Glioma is one of the most deadly central nervous system tumors around the world. Uncontrollable cell proliferation and invasion are key factors of cancer progression as well as glioma. Available evidence suggests that bromodomain PHD‑finger transcription factor (BPTF) plays an important role in stem cell proliferation and differentiation, as well as in progression of some tumors, but there is little data on glioma...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identifying the key genes and microRNAs in colorectal cancer liver metastasis by bioinformatics analysis and in  vitro experiments.
In conclusion, by using integrated bioinformatics analysis and in vitro experiments, key candidate genes were identified and novel miRNA‑mRNA regulatory axes in CRC liver metastasis were constructed, which may improve understanding of the molecular mechanisms underlying CRC liver metastasis. PMID: 30542696 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] AXL and MET receptor tyrosine kinases are essential for lung cancer metastasis.
Authors: Choi YJ, Kim JH, Rho JK, Kim JS, Choi CM, Kim WS, Son J, Lee JC Abstract Following the publication of this paper, the authors have realized that an error was made in the assembly of Fig. 1D: Specifically, the same image of migrated cells was selected for the 'Gas6' and 'HGF + Gas6' experiments pertaining to the A549 cells. The authors consider that they made this mistake during the process of copying and pasting images, owing to the similarity of the data concerned. A corrected version of Fig. 1, containing the correct data, is presented opposite. The authors sincerely apologize for this mis...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anti ‑osteopontin autoantibodies in various types of cancer.
Anti‑osteopontin autoantibodies in various types of cancer. Oncol Rep. 2018 Oct 05;: Authors: Alsarkhi LK, Weber GF Abstract The aberrant processing of biomolecules by cancer cells may give rise to autoimmune phenomena. The metastasis gene osteopontin is alternatively spliced only in transformed cells, and the variants promote tumor progression. They may also serve as tumor‑associated antigens, and their neutralization by autoantibodies could favorably affect prognosis. A competitive solid‑phase ELISA format was applied to determine reactivity toward recombinant osteopontin in human serum or plas...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway.
Authors: Ke XX, Pang Y, Chen K, Zhang D, Wang F, Zhu S, Mao J, Hu X, Zhang G, Cui H Abstract It is generally known that glioblastoma is the most common primary malignant brain tumor and that it is highly aggressive and deadly. Although surgical and pharmacological therapies have made long‑term progress, glioblastoma remains extremely lethal and has an uncommonly low survival rate. Therefore, further elucidation of the molecular mechanisms of glioblastoma initiation and its pathological processes are urgent. Arsenic resistance protein 2 (Ars2) is a highly conserved gene, and it has been found to play an important ...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research