lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR ‑18a‑5p/SOX6 signaling axis.
In conclusion, data from the present study unveil a potential ceRNA regulatory pathway, in which PART1 affects SOX6 expression level by sponging miR‑18a‑5p, to ultimately suppress ESCC development and progression. PMID: 33432363 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 13, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Radiation exposure triggers the malignancy of non ‑small cell lung cancer cells through the activation of visfatin/Snail signaling.
Radiation exposure triggers the malignancy of non‑small cell lung cancer cells through the activation of visfatin/Snail signaling. Oncol Rep. 2021 Jan 08;: Authors: Xiao L, Mao Y, Tong Z, Zhao Y, Hong H, Wang F Abstract It is estimated that one‑half of patients with non‑small cell lung cancer (NSCLC) undergo radiotherapy worldwide. However, the outcome of radiotherapy alone is not always satisfactory. The aim of the present study was to evaluate the effects of radiotherapy on the malignancy of NSCLC cells. It was demonstrated that radiation therapy could increase the migration and invasion of NSC...
Source: Oncology Reports - January 13, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Immunomodulatory potential of anticancer therapy composed of methotrexate nanoconjugate and dendritic cell ‑based vaccines in murine colon carcinoma.
In conclusion, due to its immunomodulatory properties, the HES‑MTX nanoconjugate could become a potent anticancer agent used in both chemo‑ and chemoimmunotherapeutic treatment schemes. PMID: 33432365 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 13, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

IL ‑6 plays a crucial role in epithelial‑mesenchymal transition and pro‑metastasis induced by sorafenib in liver cancer.
In conclusion, the present results indicated that IL‑6/STAT3 signaling may be a novel therapeutic strategy for liver cancer. PMID: 33432366 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 13, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of immune response biomarkers (PD ‑L1, p16, CD3+ and CD8+ TILs) in recurrent head and neck squamous cell carcinoma within previously irradiated areas.
Expression of immune response biomarkers (PD‑L1, p16, CD3+ and CD8+ TILs) in recurrent head and neck squamous cell carcinoma within previously irradiated areas. Oncol Rep. 2021 Jan 07;: Authors: Pflumio C, Thomas J, Salleron J, Faivre JC, Borel C, Dolivet G, Sastre-Garau X, Geoffrois L Abstract The immune landscape of head and neck squamous cell carcinoma in pretreated areas remains poorly documented. We aimed to assess the tumor microenvironment for biomarkers of antitumor immune responses in tumors in previously irradiated areas compared with de novo tumors. This retrospective monocentric stud...
Source: Oncology Reports - January 13, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects and mechanisms of Eps8 on the biological behaviour of malignant tumours (Review).
Authors: Luo K, Zhang L, Liao Y, Zhou H, Yang H, Luo M, Qing C Abstract Epidermal growth factor receptor pathway substrate 8 (Eps8) was initially identified as the substrate for the kinase activity of EGFR, improving the responsiveness of EGF, which is involved in cell mitosis, differentiation and other physiological functions. Numerous studies over the last decade have demonstrated that Eps8 is overexpressed in most ubiquitous malignant tumours and subsequently binds with its receptor to activate multiple signalling pathways. Eps8 not only participates in the regulation of malignant phenotypes, such as tumour...
Source: Oncology Reports - January 13, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Ski prevents TGF ‑β‑induced EMT and cell invasion by repressing SMAD‑dependent signaling in non‑small cell lung cancer.
[Corrigendum] Ski prevents TGF‑β‑induced EMT and cell invasion by repressing SMAD‑dependent signaling in non‑small cell lung cancer. Oncol Rep. 2020 Nov 25;: Authors: Yang H, Zhan L, Yang T, Wang L, Li C, Zhao J, Lei Z, Li X, Zhang HT Abstract Following the publication of the above paper, an interested reader drew to our attention apparent anomalies associated with Figs. 2, 3 and 4; essentially, these three figures contained panels exhibiting overlapping data, such that data purportedly relating to different experiments were apparently drawn from the same original sources. [Specifical...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Platelet ‑derived growth factor‑BB mediates pancreatic cancer malignancy via regulation of the Hippo/Yes‑associated protein signaling pathway.
In conclusion, the present study revealed that the Hippo/YAP signaling pathway may be involved in the tumor‑promoting activity of PDGF‑BB in pancreatic cancer. PMID: 33416116 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fangchinoline exerts antitumour activity by suppressing the EGFR ‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma. Oncol Rep. 2020 Nov 18;: Authors: Jiang F, Ren S, Chen Y, Zhang A, Zhu Y, Zhang Z, Li Z, Piao D Abstract Fangchinoline (FAN), an alkaloid extracted from Stephania tetrandra, has a variety of biological and pharmacological activities, but evidence of its effects on colon adenocarcinoma (COAD) is limited. Therefore, the present study aimed to elucidate the molecular mechanisms by which FAN affects COAD. The cytotoxicity, viability and proliferation of DLD‑1 and LoVo cells were as...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA FER1L4 inhibits cell proliferation and promotes cell apoptosis via the PTEN/AKT/p53 signaling pathway in lung cancer.
Long non‑coding RNA FER1L4 inhibits cell proliferation and promotes cell apoptosis via the PTEN/AKT/p53 signaling pathway in lung cancer. Oncol Rep. 2020 Nov 19;: Authors: Ouyang L, Yang M, Wang X, Fan J, Liu X, Zhang Y, Shu Y Abstract Long non‑coding RNA Fer‑1‑like protein 4 (FER1L4) has been reported to play crucial regulatory roles in tumor progression and apoptosis. However, its clinical significance and biological role in non‑small cell lung cancer (NSCLC) are completely unknown. The purpose of this study was to investigate the expression of lncRNA FER1L4 in plasma and tissues of pa...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Heat shock protein  90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17‑DMAG and ganetespib on tumor cells.
Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17‑DMAG and ganetespib on tumor cells. Oncol Rep. 2020 Nov 30;: Authors: Shiraishi N, Onda T, Hayashi K, Onidani K, Watanabe K, Sekikawa S, Shibahara T Abstract Heat shock protein 90 (HSP90) expression is upregulated in numerous types of cancer. However, its role as a candidate for molecular targeted therapy in oral squamous cell carcinoma (OSCC) cells is poorly understood. In the present study, a common upstream search was performed using molecular network analysis software for pr...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PD ‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review).
PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review). Oncol Rep. 2020 Nov 03;: Authors: Li CJ, Lin LT, Hou MF, Chu PY Abstract Breast cancer is a common malignant tumor in women. Triple‑negative breast cancer (TNBC) is highly invasive with a high rate of metastasis and poor prognosis. Programmed death ligand 1 (PD‑L1) plays an important role in mediating the escape of tumor cells from immune surveillance. There have been significant advances in understanding the biology of TNBC. This review presents a detailed discourse on the available data on the expression of PD‑L...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Polyphyllin  VII induces apoptosis and autophagy via mediating H2O2 levels and the JNK pathway in human osteosarcoma U2OS cells.
In conclusion, the results of the present study demonstrated that Polyphyllin VII could effectively inhibit cell viability and promote autophagy and apoptosis in U2OS cells. In addition, the mechanism underlying these effects could be associated with the intracellular H2O2 levels and the JNK signaling pathway. PMID: 33416129 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Retracted] Long non-coding RNA MEG3 inhibits cell growth of gliomas by targeting miR-93 and inactivating PI3K/AKT pathway.
Authors: Zhang L, Liang X, Li Y Abstract Following the publication of this paper, it was drawn to the authors' attention by an interested reader that certain of the tumours featured in Fig. 6A of the above paper were strikingly similar to those featured in Fig. 8A of an article appearing in International Journal of Oncology (Fan F-Y, Deng R, Yi H, Sun H-P, Zeng Y, He G-C and Su Y: The inhibitory effect of MEG3/miR-214/AIFM2 axis on the growth of T-cell lymphoblastic lymphoma. Int J Oncol 51: 316-326, 2017). The Editor asked the authors for an explanation to account for the appearance of strikingly similar data in t...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Utility of flow cytometry and gene rearrangement analysis in tissue and blood of patients with suspected cutaneous T ‑cell lymphoma.
This study aimed to evaluate the performance of the various ancillary testing modalities used to diagnose early‑stage CTCL. In a subset of patients the performance of HTS was compared to flow cytometry and conventional TCRGR analysis via polymerase chain reaction (PCR). Fifty‑five patients, with a total of 68 skin biopsies and peripheral blood draws, were evaluated using flow cytometry, PCR‑TCRGR, and HTS‑TCRGR to determine the sensitivity and specificity of each ancillary test. In tissue biopsies, flow cytometry (64%), PCR (71%) and HTS (69%) shared similar sensitivities; flow cytometry had the highest specificity...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA GAS5 inhibits malignant progression by regulating macroautophagy and forms a negative feedback regulatory loop with the miR ‑34a/mTOR/SIRT1 pathway in colorectal cancer.
lncRNA GAS5 inhibits malignant progression by regulating macroautophagy and forms a negative feedback regulatory loop with the miR‑34a/mTOR/SIRT1 pathway in colorectal cancer. Oncol Rep. 2020 Oct 26;: Authors: Zhang HG, Wang FJ, Wang Y, Zhao ZX, Qiao PF Abstract Long non‑coding RNA growth arrest specific 5 (GAS5) exerts inhibitory effects through the modulation of several target microRNAs (miRs) in cancer. However, its potential roles and underlying relationship during colorectal cancer (CRC) progression are unclear. Therefore, we explored the role of the negative feedback loop formed by ...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Methylation of the miR ‑29b‑3p promoter contributes to angiogenesis, invasion, and migration in pancreatic cancer.
This study indicated that the alteration of methylation of mR‑19b may be a potential approach for inhibiting the progression of pancreatic cancer. PMID: 33416135 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Tumor ‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer.
[Corrigendum] Tumor‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer. Oncol Rep. 2020 Nov 04;: Authors: Ji F, Sha H, Meng F, Zhu A, Ding N, Zhang H, Xu H, Qian H, Yu L, Liu Q, Liu B Abstract Following the publication of the above article, the authors noticed that data shown in certain of the panels in Figs. 4 and 5 were selected incorrectly and presented wrongly in these figures. Essentially, in Fig. 4, the data shown for the Tunel, anti‑EGFR‑iRGD and Tunel, anti‑EGFR‑iGRD+IR data panels (i.e., the ...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Phenethyl isothiocyanate reduces breast cancer stem cell-like properties by epigenetic reactivation of CDH1.
Authors: Zhang T, Zhang W, Hao M Abstract Breast cancer is the most frequently diagnosed malignancy and leading cause of cancer-related deaths among women worldwide. Tumor recurrence, or metastasis, is caused by cancer stem cells and has a dismal prognosis for breast cancer patients. Thus, targeting breast cancer stem cells (BCSCs) for eradication is a potential method to improve clinical outcomes. Phenethyl isothiocyanate (PEITC) is a novel epigenetic regulator derived from cruciferous vegetables that has marked antitumor effects. However, the exact mechanism of these antitumor effects by PEITC is unknow...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

p53 ‑p72‑Δ225‑331‑V31I identified in a cholangiocarcinoma cell line promotes migration and invasiveness via the downregulation of claudin‑1 expression and the activation of Cdc42.
p53‑p72‑Δ225‑331‑V31I identified in a cholangiocarcinoma cell line promotes migration and invasiveness via the downregulation of claudin‑1 expression and the activation of Cdc42. Oncol Rep. 2020 Oct 27;: Authors: Puetkasichonpasutha J, Suthiphongchai T Abstract TP53 is the most common gene mutated in human cancers, including in cholangiocarcinoma (CCA). The gain‑of‑function properties of p53 variants are often involved in cancer progression. The present study demonstrated that a truncated del p53 variant, del p53M213, exhibited gain‑of‑function properties and was highly expresse...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of claudin  1 on cell proliferation, migration and apoptosis in human cervical squamous cell carcinoma.
Effect of claudin 1 on cell proliferation, migration and apoptosis in human cervical squamous cell carcinoma. Oncol Rep. 2020 Dec 08;: Authors: Shen Z, Song W, Qian L, Zhu J, Li Y, Li M, Zhang T, Zhao W, Zhou Y, Yang X Abstract Claudin 1 is a member of the claudin protein family that serves an important role in tight junctions. Increased or decreased expression levels of claudin 1 are found in several diseases, including breast cancer and viral infections. However, the function of claudin 1 in cervical cancer remains controversial. The aim of the present study was to investigate the...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

EV20 ‑sss‑vc/MMAF, an HER‑3 targeting antibody‑drug conjugate displays antitumor activity in liver cancer.
EV20‑sss‑vc/MMAF, an HER‑3 targeting antibody‑drug conjugate displays antitumor activity in liver cancer. Oncol Rep. 2020 Dec 09;: Authors: D'Agostino D, Gentile R, Ponziani S, Di Vittorio G, Dituri F, Giannelli G, Rossi C, Marzullo L, Giansanti F, De Laurenzi V, Iacobelli S, Ippoliti R, Capone E, Sala G Abstract Liver cancer (LC) is an aggressive disease with a markedly poor prognosis. Therapeutic options are limited, and, until recently the only FDA‑approved agent for first‑line treatment of patients with LC was the multi‑kinase inhibitor sorafenib, which exhibits limited activity and a...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SOX12 contributes to the activation of the JAK2/STAT3 pathway and malignant transformation of esophageal squamous cell carcinoma.
In conclusion, SOX12 was revealed to serve a crucial function in sustaining the viability, as well as enhancing the motility of ESCC cells via activating the JAK2/STAT3 signaling pathway. Thus, SOX12 may potentially serve as a novel biomarker and candidate for the targeted treatment of ESCC. PMID: 33416144 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Targeting eIF4A using rocaglate CR ‑1‑31B sensitizes gallbladder cancer cells to TRAIL‑mediated apoptosis through the translational downregulation of c‑FLIP.
Targeting eIF4A using rocaglate CR‑1‑31B sensitizes gallbladder cancer cells to TRAIL‑mediated apoptosis through the translational downregulation of c‑FLIP. Oncol Rep. 2020 Nov 17;: Authors: Cao Y, He Y, Yang L, Luan Z Abstract Induction of the apoptosis of tumor cells is a promising therapeutic approach for the treatment of cancer. Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) is a novel type of anticancer drug. However, gallbladder cancer cells (GBC) exhibit strong resistance to TRAIL. The aim of the present study was to assess the effect of rocaglate CR‑1‑31B (CR‑...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

circHIPK3 promotes proliferation and migration and invasion via regulation of miR ‑637/HDAC4 signaling in osteosarcoma cells.
In conclusion, the present study uncovered the role of the circHIPK3/miR‑637/HDAC4 axis in OS cell proliferation, migration and invasion. It was demonstrated that circHIPK3 promoted OS cell proliferation, migration and invasion by modulating miR‑637/HDAC4 signaling. PMID: 33416147 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA ST8SIA6‑AS1 promotes the migration and invasion of hypoxia‑treated hepatocellular carcinoma cells through the miR‑338/MEPCE axis.
In conclusion, the findings of the present study suggest that lncRNA ST8SIA6‑AS1 may promote the migration and invasion of hypoxia‑induced HCC cells via the miR‑338/MEPCE axis, indicating a potential diagnostic or therapeutic marker for HCC treatment. PMID: 33416148 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest.
Authors: Zhang M, Lu Q, Hou H, Sun D, Chen M, Ning F, Wu P, Wei D, Duan Y, Pan Y, Lash GE Abstract Endometrial cancer (EC) is the most common gynecological cancer, and one of the most important causes of cancer‑related deaths in women worldwide. The long‑term survival rate is lower in advanced‑stage and recurrent EC, therefore it is important to identify new anticancer drugs. Garcinol, a polyisoprenylated benzophenone, is a promising anticancer drug for various cancer types but its effects on EC remain unclear. To investigate the anticancer effects of garcinol on EC, cell proliferation and cell cycle were ass...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF ‑κB signaling pathway.
In conclusion, the present present study demonstrated that CGA improved antitumor immunity, exerting antitumor and anti‑metastatic effects by impairing the NF‑κB/EMT signaling pathway, suggesting that CGA may serve as a potential candidate for therapy of breast cancer. PMID: 33416150 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Retracted] Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non ‑small lung cancer cells by regulating the YAP pathway.
[Retracted] Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway. Oncol Rep. 2020 Nov 02;: Authors: Jin D, Wu Y, Shao C, Gao Y, Wang D, Guo J Abstract An interested reader drew to our attention that the western blots featured in Figs. 1B and 6C contained strikingly similar protein bands, and repeating patterns of bands, comparing across the lanes of the gels. Furthermore, an image representing the Myc‑YAP colony‑formation assay experiment in Fig. 2C was strikingly similar t...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Selection of tumor ‑resistant variants following sustained natural killer cell‑mediated immune stress.
Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress. Oncol Rep. 2020 Nov 27;: Authors: Carré T, Thiery J, Janji B, Terry S, Gros G, Meurice G, Kieda C, Olive D, Chouaib S Abstract Resistance of tumor cells to cell‑mediated cytotoxicity remains an obstacle to the immunotherapy of cancer and its molecular basis is poorly understood. To investigate the acquisition of tumor resistance to cell‑mediated cytotoxicity, resistant variants were selected following long‑term natural killer (NK) cell selection pressure. It was observed that these var...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Exosomes derived from retinoblastoma cells enhance tumour deterioration by infiltrating the microenvironment.
Authors: Chen S, Chen X, Qiu J, Chen P, Han X, Wu Y, Zhuang J, Yang M, Wu C, Wu N, Yang Y, Ge J, Yu K, Zhuang J Abstract The survival of young children (under 5 years of age) with malignant retinoblastoma remains poor, and clarification of the mechanism underlying tumour development is urgently needed. The present study aimed to reveal the role of exosomes (EXOs) from retinoblastoma cells in tumour development. The in vitro data indicated that EXOs derived from WERI‑Rb1 cells significantly inhibited the antitumour activity of macrophages and induced bone marrow mesenchymal stem cells to promote tum...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Enhancement of cisplatin sensitivity in human breast cancer MCF-7 cell line through BiP and 14-3-3 ζ co-knockdown.
Enhancement of cisplatin sensitivity in human breast cancer MCF-7 cell line through BiP and 14-3-3ζ co-knockdown. Oncol Rep. 2020 Dec 14;: Authors: Kashkoulinejad-Kouhi T, Safarian S, Arnaiz B, Saa L Abstract Cisplatin treatment confers the relative resistance to MCF-7 cells as compared to other breast cancer cell lines. One principal reason is that chemotherapeutic agents induce autophagy in these cells to inhibit apoptosis. Binding immunoglobulin protein (BiP), a master regulator of unfolded protein response (UPR) and 14-3-3ζ are two critical proteins upregulated in breast cancer ...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Novel quinazolinone MJ ‑33 induces AKT/mTOR‑mediated autophagy‑associated apoptosis in 5FU‑resistant colorectal cancer cells.
Novel quinazolinone MJ‑33 induces AKT/mTOR‑mediated autophagy‑associated apoptosis in 5FU‑resistant colorectal cancer cells. Oncol Rep. 2020 Dec 03;: Authors: Ha HA, Chiang JH, Tsai FJ, Bau DT, Juan YN, Lo YH, Hour MJ, Yang JS Abstract Novel quinazolinone compounds have been studied in the field of drug discovery for a long time. Among their broad range of pharmacological effects, certain compounds effectively inhibit cancer cell proliferation. MJ‑33 is a quinazolinone derivative with proposed anticancer activities that was synthesized in our laboratory. The present study aimed to evaluate th...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Novel EGFR ‑bispecific recombinant immunotoxin based on cucurmosin shows potent anti‑tumor efficiency in vitro.
Novel EGFR‑bispecific recombinant immunotoxin based on cucurmosin shows potent anti‑tumor efficiency in vitro. Oncol Rep. 2020 Dec 02;: Authors: Zhang C, Cai Y, Dai X, Wu J, Lan Y, Zhang H, Lu M, Liu J, Xie J Abstract Epidermal growth factor receptor (EGFR) is overexpressed in various tumors and is associated with cancer initiation, progression, and poor prognosis. Despite the achievements made by tyrosine kinase inhibitors and monoclonal antibodies in certain cases, many patients have not benefited from such treatment due to resistance. Immunotoxins (ITs) are antibody‑cytotoxin chimeri...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genetic deletion of Rnd3 suppresses apoptosis through NF ‑κB signaling in the brain.
Genetic deletion of Rnd3 suppresses apoptosis through NF‑κB signaling in the brain. Oncol Rep. 2020 Dec 08;: Authors: Dong H, Sun Q, Zhang Y, Li Y, Yuan F, Mao S, Liu B Abstract Rho family GTPase 3 (RND3) is involved in multiple physiological activities involving the Rho kinase‑dependent signaling pathway. The present study revealed a novel role of RND3 in the regulation of apoptosis in the brain. Using immunofluorescence and TUNEL assays, a decreased rate of brain apoptosis was observed in Rnd3‑knockout mice. In addition, the function of RND3 in promoting apoptosis was determined in PC12 c...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Polyphyllin  VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer.
Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer. Oncol Rep. 2020 Dec 02;: Authors: Zhao L, Liu Z, Deng X, Wang J, Sun L, Fan L, Zhang Y Abstract Ovarian cancer is a gynecological malignancy with high mortality. Adjuvant therapy such as chemoradiotherapy inevitably leads to side effects and drug resistance. In recent years, traditional Chinese medicine has been widely studied for its safety, effectiveness, and unique pharmacological effects. Polyphyllin VII is an important component of Rhizoma paridis saponins, and has cyto...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA FOXP4 ‑AS1 predicts poor prognosis and accelerates the progression of mantle cell lymphoma through the miR‑423‑5p/NACC1 pathway.
In conclusion, FOXP4‑AS1 promotes MCL progression through the upregulation of NACC1 expression by inhibiting miR‑423‑5p. FOXP4‑AS1 may serve as a novel therapeutic target for patients with MCL. PMID: 33416160 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of in vitro and in vivo oncolytic effect in colorectal cancer cells by Orf virus strain NA1/11.
In conclusion, ORFV could be an oncolytic virus for CRC therapy. PMID: 33416161 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Downregulation of nucleolar and spindle ‑associated protein 1 expression suppresses cell migration, proliferation and invasion in renal cell carcinoma.
[Corrigendum] Downregulation of nucleolar and spindle‑associated protein 1 expression suppresses cell migration, proliferation and invasion in renal cell carcinoma. Oncol Rep. 2020 Nov 30;: Authors: Fang L, Zhang M, Chen L, Xiong H, Ge Y, Lu W, Wu X, Heng B, Yu D, Wu S Abstract Following the publication of the above article, the authors have realized that Fig. 5A was published with certain errors; essentially, the authors needed to perform further experiments to validate certain of their results, and the Blank and si‑NC control data in Fig. 5A were included from an incorrect set of e...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Zoledronic acid re ‑sensitises gefitinib‑resistant lung cancer cells by inhibiting the JAK/STAT3 signalling pathway and reversing epithelial‑mesenchymal transition.
In conclusion, ZA re‑sensitised gefitinib‑resistant lung cancer cells through inhibition of the JAK/STAT3 signalling pathway and EMT reversal. The combination of ZA and gefitinib may be a promising therapeutic strategy to reverse gefitinib resistance and prolong the survival of patients with NSCLC. PMID: 33416163 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TCF7 knockdown inhibits the imatinib resistance of chronic myeloid leukemia K562/G01 cells by neutralizing the Wnt/ β‑catenin/TCF7/ABC transporter signaling axis.
TCF7 knockdown inhibits the imatinib resistance of chronic myeloid leukemia K562/G01 cells by neutralizing the Wnt/β‑catenin/TCF7/ABC transporter signaling axis. Oncol Rep. 2020 Nov 27;: Authors: Zhang H, Wang Y, Yang H, Huang Z, Wang X, Feng W Abstract Clinical resistance to ABL tyrosine kinase inhibitor (TKI) imatinib remains a critical issue in the treatment of chronic myeloid leukemia (CML). Transcription factor 7 (TCF7) is one of the main Wnt/β‑catenin signaling mediators. Previous studies have shown that TCF7 is vital for tumor initiation, and targeting TCF7 can reduce dru...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression and role of fibroblast activation protein α in acute myeloid leukemia.
Expression and role of fibroblast activation protein α in acute myeloid leukemia. Oncol Rep. 2020 Nov 30;: Authors: Mei S, Zhang Y, Yu L, Chen G, Zi F Abstract Currently, the prognosis of acute myeloid leukemia (AML) is poor. In the AML microenvironment, bone marrow (BM) mesenchymal stem cells (BMMSCs) serve an important role in protecting AML cells from chemotherapy‑induced apoptosis. The present study aimed to evaluate the expression of fibroblast activation protein α (FAPα) in BMMSCs and BM biopsy samples via flow cytometry, reverse transcription‑quanti...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Erb ‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells.
In conclusion, the findings of the present study suggested ERBB2 as an oncogenic protein that may promote invasiveness in cervical cancer cells. Treatment of cervical cancer cells with the p53 activator Mithramycin A restored the levels of the endogenous ERBB2 inhibitor miR‑3184‑5p and may represent a novel treatment strategy for cervical cancer. PMID: 33416166 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Involvement of Blnk and Foxo1 in tumor suppression in BCR ‑ABL1‑transformed pro‑B cells.
Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells. Oncol Rep. 2020 Dec 08;: Authors: Zhang P, Wang Y, Qin M, Li D, Odhiambo WO, Yuan M, Lv Z, Liu C, Ma Y, Dong Y, Ji Y Abstract Oncogenic Bcr‑Abl kinase mimics pre‑B cell receptor (pre‑BCR) survival signals in BCR‑ABL1‑positive B‑cell acute lymphoblastic leukemia (BCR‑ABL1+ B‑ALL), driving B‑cell progenitor malignant transformation; thus, defining a particularly unfavorable prognosis for patients. During B‑cell development, pre‑BCR differentiation signaling components terminate proliferativ...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Potential roles of exosome non ‑coding RNAs in cancer chemoresistance (Review).
Potential roles of exosome non‑coding RNAs in cancer chemoresistance (Review). Oncol Rep. 2020 Dec 08;: Authors: Wang Y, Liu Q, Wang F Abstract Multiple studies have demonstrated chemoresistance in multiple types of tumor, which limits the effectiveness of cancer treatments. Chemoresistance often contributes to cancer relapse. Non‑coding RNAs, are a group of regulatory RNAs, that are involved in tumor drug resistance. Exosomes, membranous vesicles secreted by cells, are reported to mediate cell‑to‑cell communication, including in cancer. Furthermore, exosomal non‑coding RNAs have been reporte...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA CASC19 promotes glioma progression by modulating the miR‑454‑3p/RAB5A axis and is associated with unfavorable MRI features.
Long non‑coding RNA CASC19 promotes glioma progression by modulating the miR‑454‑3p/RAB5A axis and is associated with unfavorable MRI features. Oncol Rep. 2020 Dec 01;: Authors: Wu YJ, Yang QS, Chen H, Wang JT, Wang WB, Zhou L Abstract Glioma is one of the most common malignancies of the nervous system. Long non‑coding RNAs (lncRNAs) are regulators involved in the progression of tumors. The present study aimed to determine the role of lncRNA cancer susceptibility 19 (CASC19) in glioma and its underlying molecular mechanism. Reverse transcription‑quantitative PCR was performed to detect CASC19...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miRNA ‑199b‑3p suppresses growth and progression of ovarian cancer via the CHK1/E‑cadherin/EMT signaling pathway by targeting ZEB1.
miRNA‑199b‑3p suppresses growth and progression of ovarian cancer via the CHK1/E‑cadherin/EMT signaling pathway by targeting ZEB1. Oncol Rep. 2020 Dec 11;: Authors: Wei L, He Y, Bi S, Li X, Zhang J, Zhang S Abstract Ovarian cancer is one of the most common gynecological malignancies and its pathogenesis and progression are regulated by multiple genes. MicroRNAs (miRNAs) are endogenous non‑coding RNAs that regulate body function by altering post‑transcriptional gene expression. Previous studies have suggested that miRNAs are closely associated with the pathogenesis and progression of seve...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Osteopontin ‑c isoform inhibition modulates ovarian cancer cell cisplatin resistance, viability and plasticity.
Osteopontin‑c isoform inhibition modulates ovarian cancer cell cisplatin resistance, viability and plasticity. Oncol Rep. 2020 Dec 01;: Authors: Brum MCM, Dos Santos Guimaraes I, Ferreira LB, Rangel LBA, Maia RC, Nestal De Moraes G, Gimba ERP Abstract Osteopontin (OPN) is upregulated in several types of tumor and has been associated with chemoresistance. However, the contribution of OPN splicing isoforms (OPN‑SIs) to chemoresistance requires further investigation. The present study aimed to evaluate the expression patterns of each tested OPN‑SI in cisplatin (CDDP)‑resistant ovarian carcinoma ce...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Multifunctional nanoparticle PEG ‑Ce6‑Gd for MRI‑guided photodynamic therapy.
Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy. Oncol Rep. 2020 Nov 27;: Authors: Xu D, Baidya A, Deng K, Li YS, Wu B, Xu HB Abstract Gliomas are one of the most common types of primary brain tumors. Despite recent advances in the combination of surgery, radiotherapy, systemic therapy (chemotherapy, targeted therapy) and supportive therapy in the multimodal treatment of gliomas, the overall prognosis remains poor and the long‑term survival rate is low. Thus, it is crucial to develop a novel glioma management method. Due to its relatively non‑invasive, selective an...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

IGFBP2 in cancer: Pathological role and clinical significance (Review).
Authors: Wei LF, Weng XF, Huang XC, Peng YH, Guo HP, Xu YW Abstract The versatility of IGFBP2, as a secreted protein in cancer cells or a cytoplasmic signaling effector, has been extensively investigated in many malignant cancers. Over the last few decades, IGFBP2, a key member of the IGFBP family, has been identified as an important oncogene in multiple human cancers. In addition, a growing number of studies have shown that IGFBP2 is greatly elevated in serum or tissue in patients with malignant tumors and plays an essential role in several key oncogenic processes, such as tumor cellular proliferation, migration, ...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research