[Corrigendum] FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment.
Authors: Zhong Z, Zhang H, Hong M, Sun C, Xu Y, Chen X, Gao C, He M, Liu W, Liang J Abstract During the preparation of the above article, the authors inadvertently selected an incorrect pair of data panels for Fig. 5B. Essentially, in the published version of Fig. 5B, the images were presented incorrectly for the NC migration and KD#3 migration and invasion data panels associated with the TSCCA cell Transwell assay experiments. Furthermore, in Fig. 7A, the GAPDH control bands were erroneously selected for the figure. Figs. 5 and 7 as they should have appeared in the Journal are shown opposite, i...
Source: Oncology Reports - October 29, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SPAG6 promotes cell proliferation and inhibits apoptosis through the PTEN/PI3K/AKT pathway in Burkitt lymphoma.
Authors: Zhang R, Zhu H, Yuan Y, Wang Y, Tian Z Abstract The main purpose of the present study was to elucidate the role of sperm‑associated antigen 6 (SPAG6) in the occurrence and development of Burkitt lymphoma (BL) and explore the underlying molecular mechanisms. A correlation was observed between the expression of SPAG6 and the prognosis of patients with lymphoma using The Cancer Genome Atlas (TCGA) database analysis. It was demonstrated that the levels of SPAG6 in BL cells were higher compared with that in IM‑9 cells by reverse transcription‑PCR and western blot assays. Moreover, silencing of S...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

M2 ‑TAM subsets altered by lactic acid promote T‑cell apoptosis through the PD‑L1/PD‑1 pathway.
M2‑TAM subsets altered by lactic acid promote T‑cell apoptosis through the PD‑L1/PD‑1 pathway. Oncol Rep. 2020 Nov;44(5):1885-1894 Authors: Shan T, Chen S, Chen X, Wu T, Yang Y, Li S, Ma J, Zhao J, Lin W, Li W, Cui X, Kang Y Abstract The aim of the study was to investigate the effects of lactic acid on the phenotypic polarization and immune function of macrophages. The human monocyte/macrophage cell line, THP‑1, was selected and treated with lactic acid. Immunofluorescence staining, laser confocal microscopy, reverse‑transcription polymerase chain reaction (RT‑PCR), western blot, siRNA, a...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Attenuated measles virus overcomes radio ‑ and chemoresistance in human breast cancer cells by inhibiting the non‑homologous end joining pathway.
Attenuated measles virus overcomes radio‑ and chemoresistance in human breast cancer cells by inhibiting the non‑homologous end joining pathway. Oncol Rep. 2020 Nov;44(5):2253-2264 Authors: Yang B, Shi J, Sun Z, Zhu D, Xu X Abstract Breast cancer is the most commonly diagnosed cancer and is the second leading cause of death in women. However, resistance to radio‑ and chemotherapy remains one of the major difficulties in the treatment of breast cancer. Therefore, the aim of the present study was to identify novel regimens to overcome treatment resistance in patients with breast cancer. The results...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma.
In conclusion, overexpression of DEF6 is significantly correlated with a poor prognosis for patients with ccRCC and DEF6 may influence the biological processes involved with ccRCC by regulating the immune microenvironment. PMID: 33000227 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor ‑sensitive and ‑resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B.
AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor‑sensitive and ‑resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B. Oncol Rep. 2020 Nov;44(5):2211-2218 Authors: Takeda T, Tsubaki M, Genno S, Nemoto C, Onishi Y, Yamamoto Y, Imano M, Satou T, Nishida S Abstract Imatinib is the gold standard in the conventional treatment of chronic myeloid leukemia (CML). However, some patients become resistant to imatinib therapy. To overcome this resistance, second‑generation (dasatinib, nilotinib, and bosutinib) and third‑generation (ponatinib) tyrosine kin...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑875‑5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
In conclusion, miR‑875‑5p, which was downregulated in HCC, may inhibit tumor growth and metastasis by eIF3a downregulation via targeting its 3'UTR and may be a promising prognostic and therapeutic strategy in HCC. PMID: 33000235 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Circular RNAs: Novel biomarkers for cervical, ovarian and endometrial cancer (Review).
Authors: Shi Y, He R, Yang Y, He Y, Shao K, Zhan L, Wei B Abstract Cervical, ovarian and endometrial cancer are the three most common types of malignant tumor and the leading causes of cancer‑associated death in women. Tumor debulking surgery followed by platinum and paclitaxel chemotherapy is the current treatment regime of choice. However, as a result of late diagnosis and chemoresistance, the survival rates of patients with advanced gynecological cancers remains unsatisfactory. Circular RNAs (circRNAs) are stable noncoding RNAs that are present in a wide variety of tissue and cell types. With the enhancement o...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients.
Authors: Vodenkova S, Kroupa M, Polivkova Z, Musak L, Ambrus M, Schneiderova M, Kozevnikovova R, Vodickova L, Rachakonda S, Hemminki K, Kumar R, Vodicka P Abstract Accumulation of non‑specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are po...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1 ‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats. Oncol Rep. 2020 Nov;44(5):2306-2316 Authors: Li M, Liu P, Xue Y, Liang Y, Shi J, Han X, Zhang J, Chu X, Chu L Abstract The present study was performed to investigate the protective effects of tannic acid (TA) on liver injury induced by arsenic trioxide (ATO) and to elucidate the mechanism involved as related to the Kelch‑like ECH‑associated protein 1 (Keap1)‑nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant respo...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A defucosylated anti ‑CD44 monoclonal antibody 5‑mG2a‑f exerts antitumor effects in mouse xenograft models of oral squamous cell carcinoma.
A defucosylated anti‑CD44 monoclonal antibody 5‑mG2a‑f exerts antitumor effects in mouse xenograft models of oral squamous cell carcinoma. Oncol Rep. 2020 Nov;44(5):1949-1960 Authors: Takei J, Kaneko MK, Ohishi T, Hosono H, Nakamura T, Yanaka M, Sano M, Asano T, Sayama Y, Kawada M, Harada H, Kato Y Abstract CD44 is widely expressed on the surface of most tissues and all hematopoietic cells, and regulates many genes associated with cell adhesion, migration, proliferation, differentiation, and survival. CD44 has also been studied as a therapeutic target in several cancers. Previously, an anti‑CD4...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Transient impact of paclitaxel on mouse fertility and protective effect of gonadotropin ‑releasing hormone agonist.
Transient impact of paclitaxel on mouse fertility and protective effect of gonadotropin‑releasing hormone agonist. Oncol Rep. 2020 Nov;44(5):1917-1928 Authors: Ma N, Chen G, Chen J, Cui M, Yin Y, Liao Q, Tang M, Feng X, Li X, Zhang S, Ma D, Chen G, Li K, Ai J Abstract Paclitaxel (PXL) is a chemotherapeutic agent widely used in solid tumors. However, whether PXL causes premature ovarian insufficiency in women of reproductive age remains controversial. The aim of the present study was to answer how and for how long PXL affects fertility, and to identify the protective effect of gonadotropin‑releasing...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Bioinformatics analysis of LINC01554 and its co ‑expressed genes in hepatocellular carcinoma.
Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma. Oncol Rep. 2020 Nov;44(5):2185-2197 Authors: Li L, Huang K, Lu Z, Zhao H, Li H, Ye Q, Peng G Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer‑related morbidity and mortality globally. Despite the remarkable improvements in comprehensive HCC treatment, the underlying mechanistic details of HCC remain elusive. We screened HCC patients for differentially expressed genes (DEGs) using the Gene Expression Omnibus (GSE113850) and The Cancer Genome Atlas (TCGA) datasets. LINC01554 expressio...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Selection of microRNAs in extracellular vesicles for diagnosis of malignant pleural mesothelioma by in  vitro analysis.
In this study, culture media were passed sequentially through membrane filters 220‑50 nm in size, and EVs with diameters of 50 to 220 nm (EVcap50/220) were collected. miRNAs (EV50‑miRNAs) in EVcap50/220 were purified, and microarray analysis was performed. EV50‑miRNA expression profiles were compared between MPM cells and a normal pleural mesothelial cell line, and six EV50‑miRNAs were selected for further investigation. Of these, hsa‑miR‑193a‑5p and hsa‑miR‑551b‑5p demonstrated higher expression in MPM‑derived EVcap50/220. These miRNAs reduced the expression of several genes involved in cel...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA PLK1S1 was associated with renal cell carcinoma progression by interacting with microRNA‑653 and altering C‑X‑C chemokine receptor 5 expression.
In conclusion, the present study revealed that PLK1S1 promoted tumor progression and sorafenib resistance in RCC through regulation of the miR‑653/CXCR5 axis, which may offer a novel treatment strategy for patients with RCC. PMID: 33000253 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long noncoding RNAs, ENST00000598996 and ENST00000524265, are correlated with favorable prognosis and act as potential tumor suppressors in bladder cancer.
Authors: Shen C, Wang Y, Wu Z, Da, Gao S, Xie L, Qie Y, Wang Y, Zhang Z, Tian D, Hu H Abstract Bladder cancer (BC) is a serious malignancy worldwide due to its distant metastasis and high recurrence rates. Increasing evidence has indicated that dysregulated long non‑coding RNAs (lncRNAs) are involved in tumorigenesis and progression in multiple malignancies. However, their clinical significances, biological functions and molecular mechanisms in BC remain poorly understood. Hence, the present study investigated the expression profile of lncRNAs and mRNAs in five BC tissues and the corresponding adjacent normal spe...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of SERPINE1 reverses resistance of triple ‑negative breast cancer to paclitaxel via suppression of VEGFA.
Knockdown of SERPINE1 reverses resistance of triple‑negative breast cancer to paclitaxel via suppression of VEGFA. Oncol Rep. 2020 Nov;44(5):1875-1884 Authors: Zhang Q, Lei L, Jing D Abstract Breast cancer (BC) has a poor prognosis and a high number of visceral metastases. Serine protease inhibitor, clade E member 1 (SERPINE1) is a molecule involved in several human malignancies. However, it remains unknown if SERPINE1 plays a role in the development of taxane resistance in TNBC cells. In the present study, the role and mechanism of SERPINE1 in the development of paclitaxel (PTX) resistance in TNBC c...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA RASSF8 ‑AS1 suppresses the progression of laryngeal squamous cell carcinoma via targeting the miR‑664b‑3p/TLE1 axis.
In conclusion, the RASSF8‑AS1/miR‑664b‑3p/TLE1 axis acts by suppressing LSCC progression and may provide a novel insight for the molecular mechanism of LSCC. PMID: 33000257 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sorting Nexin 27 as a potential target in G  protein‑coupled receptor recycling for cancer therapy (Review).
Sorting Nexin 27 as a potential target in G protein‑coupled receptor recycling for cancer therapy (Review). Oncol Rep. 2020 Nov;44(5):1779-1786 Authors: Bao Z, Zhou S, Zhou H Abstract G protein‑coupled receptors (GPCRs) are the largest family of membrane receptors and activate several downstream signaling pathways involved in numerous physiological cellular processes. GPCRs are usually internalized and desensitized by intracellular signals. Numerous studies have shown that several GPCRs interact with sorting nexin 27 (SNX27), a cargo selector of the retromer complex, and are recycled...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

RP11 ‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma.
RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma. Oncol Rep. 2020 Nov;44(5):2080-2092 Authors: Yan J, Wang ZH, Yan Y, Luo HN, Ren XY, Li N, Zheng GX, Hou J Abstract Emerging studies have demonstrated that long non‑coding RNAs (lncRNAs) play essential roles in tumorigenesis. However, the role and function of lncRNAs in hypopharyngeal squamous cell carcinoma (HSCC) have not been completely elucidated. The present study explored the function of a novel lncRNA, RP11‑156L14.1, in HSCC. RP11‑156L14.1 was revealed to be high...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Association of tricellulin expression with poor colorectal cancer prognosis and metastasis.
Authors: Zhang JX, Qin MB, Ye Z, Peng P, Li SM, Song Q, Lin L, Liu SQ, Xie LH, Zhu Y, Huang JA Abstract Tricellulin is a tight‑junction transmembrane protein that regulates cell‑cell interactions. Altered tricellulin expression could promote tumor cell invasions and metastasis in human cancers. The present study assessed tricellulin expression in colorectal cancer tissues for any association with clinicopathological features of colorectal cancer patients and then investigated the underlying molecular events using quantitative proteomic analysis and in vitro experiments. Tissue samples from 98 colorectal ca...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Andrographolide sensitizes human renal carcinoma cells to TRAIL ‑induced apoptosis through upregulation of death receptor 4.
Andrographolide sensitizes human renal carcinoma cells to TRAIL‑induced apoptosis through upregulation of death receptor 4. Oncol Rep. 2020 Nov;44(5):1939-1948 Authors: Bi R, Deng Y, Tang C, Xuan L, Xu B, Du Y, Wang C, Wei W Abstract Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) selectively induces apoptosis in cancer cells, with minimal toxicity to normal tissues. However, accumulating evidence suggests that certain cancer types are insensitive to TRAIL signaling. The aim of this study was to identify an effective combination regimen, which can overcome TRAIL resistance in rena...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Triptolide induces apoptosis through the calcium/calmodulin ‑dependent protein kinase kinaseβ/AMP‑activated protein kinase signaling pathway in non‑small cell lung cancer cells.
In conclusion, the results of the present study suggested that triptolide may induce apoptosis through the CaMKKβ‑AMPK signaling pathway and may be a promising drug for the treatment of NSCLC. PMID: 33000264 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT ‑116 cells.
Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells. Oncol Rep. 2020 Nov;44(5):1997-2008 Authors: Xiang L, He B, Liu Q, Hu D, Liao W, Li R, Peng X, Wang Q, Zhao G Abstract Curcumin is the main component of the Chinese herbal plant turmeric, which has been demonstrated to possess antitumor and other pharmacological properties. The aim of the present study was to investigate the effects of curcumin on the viability, migration and apoptosis of human colorectal carcinoma HCT‑116 cells, and to explore the underlying molecular mechanisms...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑422a functions as a tumor suppressor in glioma by regulating the Wnt/β‑catenin signaling pathway via RPN2.
In conclusion, the present data reveal a new miR‑422a/RPN2/Wnt/β‑catenin signaling axis that plays critical roles in glioma tumorigenesis, and it represents a potential therapeutic target for GBM. PMID: 33000268 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] MicroRNA-375 inhibits glioma cell proliferation and migration by downregulating RWDD3 in vitro.
Authors: Ji CX, Fan YH, Xu F, Lv SG, Ye MH, Wu MJ, Zh XG, Wu L Abstract The authors of the above article drew to our attention that they had identified three instances of data overlapping between data panels, suggesting that data purportedly showing results obtained under different experimental conditions had been derived from the same original source. Comparing between the two figures, two pairs of panels in Fig. 4B (the Mimics control and blank experiments for the U87 and U251 cell lines) were shown to be overlapping, and a further pair of panels showed overlapping data in Fig. 6B (the data panels for t...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Luteolin, an aryl hydrocarbon receptor ligand, suppresses tumor metastasis in  vitro and in vivo.
In conclusion, luteolin is a potential molecule for inhibiting breast cancer invasion and metastasis, which could have promising clinical applications. PMID: 33000272 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

N ‑Myc induces the tumor progression of prostate cancer by regulating FSCN1.
N‑Myc induces the tumor progression of prostate cancer by regulating FSCN1. Oncol Rep. 2020 Nov;44(5):2265-2274 Authors: He G, Li M, Fang L, Xu L, Huang X, Zheng L, Yang L, Luo W, Cai Y, Ma W, Liang C, Yin Y Abstract The oncoprotein N‑Myc has a carcinogenic effect in numerous types of cancer, and it can cause castration resistance in prostate cancer (PCa), and leads to the development of small cell neuroendocrine cancer by regulating multiple target genes. Immunohistochemical staining, RT‑qPCR, western blotting, wound healing and CCK‑8 assays were used to detect the expression of N‑Myc and FS...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Involvement of non ‑triple helical type VI collagen α1 chain, NTH α1(VI), in the proliferation of cancer cells.
In conclusion, fragmentation of NTH α1(VI) into peptides
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HSH2D contributes to methotrexate resistance in  human T‑cell acute lymphoblastic leukaemia.
In conclusion, the results suggested that HSH2D serves an important role in the resistance of T‑ALL to MTX, which provides a potential research target for the study of drug resistance of T‑ALL. PMID: 33000278 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of E2F5 induces cell death via the TP53 ‑dependent pathway in breast cancer cells carrying wild‑type TP53.
Knockdown of E2F5 induces cell death via the TP53‑dependent pathway in breast cancer cells carrying wild‑type TP53. Oncol Rep. 2020 Nov;44(5):2241-2252 Authors: Inagaki Y, Wu D, Fujiwara K, Ishizuka Y, Oguni A, Tokunaga T, Takayama T, Soma M, Fukuda N, Ozaki T, Masuda S Abstract E2F transcription factor 5 (E2F5) is a member of the E2F family of transcription factors, which are involved in regulation of various cellular processes, including cellular proliferation, apoptosis, differentiation and DNA damage response. Previously, we reported that E2F5 was aberrantly overexpressed in estrogen receptor (...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway.
In conclusion, overexpression of STAU1 was associated with immune response and regulated AS of pathways related to neuronal growth and repair. In the present study, the whole transcriptome of STAU1 expression was first analyzed, which laid a foundation for further understanding the key functions of STAU1. PMID: 33000283 [PubMed - in process] (Source: Oncology Reports)
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Roles of galectin ‑3 in the tumor microenvironment and tumor metabolism (Review).
Roles of galectin‑3 in the tumor microenvironment and tumor metabolism (Review). Oncol Rep. 2020 Nov;44(5):1799-1809 Authors: Guo Y, Shen R, Yu L, Zheng X, Cui R, Song Y, Wang D Abstract Galectin‑3 is expressed in various tissues and plays an important role in the tumor microenvironment (TME). Galectin‑3 has been found to be overexpressed in a variety of cancers and is associated with tumor progression and metastasis. Over the past decades, emerging evidence has suggested that the TME may induce galectin‑3 expression to maintain cellular homeostasis and promote cell survival. Furthermore, galec...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis.
Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis. Oncol Rep. 2020 Jul 17;: Authors: Wen J, Han S, Cui M, Wang Y Abstract The long non‑coding RNA (lncRNA) MCM3AP antisense 1 (MCM3AP‑AS1) has previously been shown to be a key regulator of multiple types of cancer; however whether it is important in the context of ovarian cancer (OC) is uncertain. The present study determined that MCM3AP‑AS1 expression in samples from patients with OC was significantly increased, and was associated with tumor stage, presence of lymph node metastases and poore...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA NR2F1‑AS1 facilitates the osteosarcoma cell malignant phenotype via the miR‑485‑5p/miR‑218‑5p/BIRC5 axis.
Long non‑coding RNA NR2F1‑AS1 facilitates the osteosarcoma cell malignant phenotype via the miR‑485‑5p/miR‑218‑5p/BIRC5 axis. Oncol Rep. 2020 Jul 20;: Authors: Jia G, Wang Y, Yu Y, Li Z, Wang X Abstract Long non‑coding RNA (lncRNA) NR2F1 antisense RNA 1 (NR2F1‑AS1) has been reported to be an oncogene in several cancer types, including osteosarcoma (OS). However, the underlying fundamental molecular mechanism of NR2F1‑AS1 in OS remains largely unknown, which the present study aimed to elucidate. The present study demonstrated that NR2F1‑AS1 expression is markedly increased in OS, and...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Non ‑coding RNAs that regulate the Wnt/β‑catenin signaling pathway in gastric cancer: Good cop, bad cop? (Review).
Non‑coding RNAs that regulate the Wnt/β‑catenin signaling pathway in gastric cancer: Good cop, bad cop? (Review). Oncol Rep. 2020 Jul 28;: Authors: Shao Z, Gao D, Chen L, Ding W, Yu Q Abstract Gastric cancer (GC) is one of the most common causes of cancer‑related mortality worldwide. Despite remarkable progress in the diagnosis and treatment of GC, a large number of cases are diagnosed as advanced GC, and treatment failure occurs. Emerging evidence has shown that non‑coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long non‑coding RNAs (lncRNAs), play a vital role in the tumorigen...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA PCNAP1 predicts poor prognosis in breast cancer and promotes cancer metastasis via miR ‑340‑5p‑dependent upregulation of SOX4.
lncRNA PCNAP1 predicts poor prognosis in breast cancer and promotes cancer metastasis via miR‑340‑5p‑dependent upregulation of SOX4. Oncol Rep. 2020 Jul 20;: Authors: Yu Y, He Y, Shao Y, Chen Q, Liu H Abstract The high metastatic rate of breast cancer is the significant cause of its poor prognosis. The long noncoding RNA (lncRNA) proliferating cell nuclear antigen pseudogene 1 (PCNAP1) plays important roles in the initiation and progression of cancers; however, its regulatory function and molecular mechanism in breast cancer metastasis remains unknown. Therefore, we investigated the roles of lncR...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of non ‑small‑cell lung cancer by sponging microRNA‑509‑3p and competitively upregulating HDAC9 expression.
Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of non‑small‑cell lung cancer by sponging microRNA‑509‑3p and competitively upregulating HDAC9 expression. Oncol Rep. 2020 Aug 07;: Authors: Guan Y, Yang J, Liu X, Chu L Abstract Long noncoding RNA CBR3 antisense RNA 1 (CBR3‑AS1) plays significant roles in the initiation and progression of osteosarcoma. The aim of the present study was to investigate the involvement of CBR3‑AS1 in the development of non‑small cell lung cancer (NSCLC). Reverse transcription‑quantitative PCR was performed to detect CBR3‑AS1 ...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Resveratrol synergizes with cisplatin in antineoplastic effects against AGS gastric cancer cells by inducing endoplasmic reticulum stress ‑mediated apoptosis and G2/M phase arrest.
In conclusion, RES and DDP synergistically inhibited the growth of the gastric adenocarcinoma cell line AGS by inducing endoplasmic reticulum stress‑mediated apoptosis and G2/M phase arrest via activation of the PERK/eIF2α/activating transcription factor 4 (ATF4)/CHOP signaling pathway and caspase‑12 and by inactivating the CDK1‑cyclin B1 complex. These results indicated that RES is a promising adjuvant for DDP during GC chemotherapy. PMID: 32945472 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Xanthohumol targets the ERK1/2 ‑Fra1 signaling axis to reduce cyclin D1 expression and inhibit non‑small cell lung cancer.
Xanthohumol targets the ERK1/2‑Fra1 signaling axis to reduce cyclin D1 expression and inhibit non‑small cell lung cancer. Oncol Rep. 2020 Jul 20;: Authors: Gao F, Li M, Zhou L, Liu W, Zuo H, Li W Abstract High expression of cyclin D1 has a crucial role in the maintenance of unlimited cell growth in human cancer cells. The present study indicated that cyclin D1 was overexpressed in human non‑small cell lung cancer (NSCLC) tumor tissues and cell lines. Knockout of cyclin D1 suppressed NSCLC cell growth, colony formation and in vivo tumor growth. Of note, the natural product xanthohumol (Xanth)...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of LINC00958 inhibits proliferation, invasion and migration, and promotes apoptosis of colorectal cancer cells by targeting miR ‑3619‑5p.
Downregulation of LINC00958 inhibits proliferation, invasion and migration, and promotes apoptosis of colorectal cancer cells by targeting miR‑3619‑5p. Oncol Rep. 2020 Jul 29;: Authors: Sun Y, Liu Y, Cai Y, Han P, Wang R, Cao L, He S Abstract The aberrant expression of long non‑coding RNAs (lncRNAs), including LINC00958, has been demonstrated in several types cancers. The present study aimed to investigate the role of LINC00958 in colorectal cancer (CRC) and identify the possible underlying mechanisms. The expression of LINC00958 and microRNA (miR)‑3619‑5p was detected in several human CRC ce...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma.
Authors: An YW, Liu HQ, Zhou ZQ, Wang JC, Jiang GY, Li ZW, Wang F, Jin HT Abstract The aim of the present study was to explore the antitumor effects of sinoporphyrin sodium (DVDMS)‑mediated photodynamic therapy (PDT) and sonodynamic therapy (SDT) in glioma, and to reveal the underlying mechanisms. The uptake of DVDMS by U‑118 MG cells was detected by flow cytometry (FCM). A 630‑nm semiconductor laser and 1‑MHz ultrasound were used to perform PDT and SDT, respectively. Cell proliferation and apoptosis were evaluated using the Cell Counting Kit‑8 assay, FCM and Hoechst 33258 staining, respectively. Western ...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA SNHG3 promotes breast cancer  progression by acting as a miR‑326 sponge.
lncRNA SNHG3 promotes breast cancer progression by acting as a miR‑326 sponge. Oncol Rep. 2020 Jul 15;: Authors: Zhang H, Wei N, Zhang W, Shen L, Ding R, Li Q, Li S, Du Y Abstract Accumulating evidence suggests that long noncoding RNA (lncRNA) small nucleolar RNA host gene 3 (SHNG3) plays crucial roles in the initiation and progression of various types of malignant cancers. Yet, the role played by SNHG3 in breast cancer as well as the associated mechanisms remain largely unclear. The expression of SNHG3 was detected in breast cancer tissues and cell lines by reverse‑transcription quantita...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LncRNA TTN ‑AS1 promotes endometrial cancer by sponging miR‑376a‑3p.
LncRNA TTN‑AS1 promotes endometrial cancer by sponging miR‑376a‑3p. Oncol Rep. 2020 Jul 15;: Authors: Shen L, Wu Y, Li A, Li L, Shen L, Jiang Q, Li Q, Wu Z, Yu L, Zhang X Abstract Increasing research has demonstrated that lncRNAs participate in the development of multiple cancer types. However, the role of TTN‑AS1 in endometrial cancer (EC) remains unknown. The present study aimed to explore the function of titin‑antisense RNA1 (TTN‑AS1) in EC progression and the underlying mechanisms. qRT‑PCR was performed to assess the TTN‑AS1 expression patterns in EC tissues and cell lines. Loss of ...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6.
MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6. Oncol Rep. 2020 Jul 15;: Authors: Guan H, Liu J, Lv P, Zhou L, Zhang J, Cao W Abstract MicroRNA‑590 (miR‑590) has been revealed as a tumor suppressor, while low‑density lipoprotein receptor‑related protein 6 (LRP6) is considered to act as a tumor promoter. However, their roles and underlying molecular regulatory mechanisms in esophageal squamous cell carcinoma (ESCC) have yet to be fully eluc...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non coding RNA OIP5 ‑AS1 promotes metastasis of breast cancer via miR‑340‑5p/ZEB2 axis.
Long non coding RNA OIP5‑AS1 promotes metastasis of breast cancer via miR‑340‑5p/ZEB2 axis. Oncol Rep. 2020 Aug 10;: Authors: Meng L, Yue X, Zhou D, Li H Abstract Breast cancer is the most common invasive cancer in women with the highest number of related deaths which is caused by distal metastasis. Recently, integrated analysis of gene expression profile suggested widespread gene dysregulation in various types of cancer. Research in the past decade has focused on long non‑coding RNAs (lncRNAs), particularly in cell proliferation, tumor progression and metastasis. OPA‑interacting protein ...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑30a‑5p inhibits hypoxia/reoxygenation‑induced oxidative stress and apoptosis in HK‑2 renal tubular epithelial cells by targeting glutamate dehydrogenase 1 (GLUD1).
miR‑30a‑5p inhibits hypoxia/reoxygenation‑induced oxidative stress and apoptosis in HK‑2 renal tubular epithelial cells by targeting glutamate dehydrogenase 1 (GLUD1). Oncol Rep. 2020 Aug 07;: Authors: He Y, Lang X, Cheng D, Zhang T, Yang Z, Xiong R Abstract MicroRNAs (miRNAs) are reported to be involved in renal hypoxia/reoxygenation (H/R) damage. To investigate this further, human kidney (HK‑2) cells were cultured, subjected to H/R and the function of miR‑30a‑5p and glutamate dehydrogenase 1 (GLUD1) was evaluated. The results showed that, miR‑30‑5p was downregulated and GLUD1 was up...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long noncoding RNA PSMA3 ‑AS1 functions as a microRNA‑409‑3p sponge to promote the progression of non‑small cell lung carcinoma by targeting spindlin 1.
Long noncoding RNA PSMA3‑AS1 functions as a microRNA‑409‑3p sponge to promote the progression of non‑small cell lung carcinoma by targeting spindlin 1. Oncol Rep. 2020 Jul 15;: Authors: Wang L, Wu L, Pang J Abstract PSMA3 antisense RNA 1 (PSMA3‑AS1), a long noncoding RNA, promotes the progression of esophageal squamous cell carcinoma. However, no study to date has explored the expression or roles of PSMA3‑AS1 in non‑small cell lung carcinoma (NSCLC). The present study examined the expression profile and role of PSMA3‑AS1 in NSCLC. It also aimed to identify how PSMA3‑AS1 promotes ...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
Authors: Zhang X, Liu T, Zheng S, Liu Q, Shen T, Han X, Zhang Q, Yang L, Lu X Abstract A previous proteomic screening of differentially expressed biomarkers between Kazakh patients with esophageal squamous cell carcinoma (ESCC) and normal adjacent tissues demonstrated that heat shock protein 27 (HSP27) and pyruvate kinase isoenzyme M2 (PKM2) were both highly expressed in ESCC samples compared with normal controls. However, the regulatory association between HSP27 and PKM2 in ESCC remains elusive. In the present study, immunohistochemistry and immunoblotting were adopted to examine the expression of HSP27, PKM2 and ...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Kevetrin induces apoptosis in TP53 wild ‑type and mutant acute myeloid leukemia cells.
Kevetrin induces apoptosis in TP53 wild‑type and mutant acute myeloid leukemia cells. Oncol Rep. 2020 Aug 11;: Authors: Napolitano R, De Matteis S, Carloni S, Bruno S, Abbati G, Capelli L, Ghetti M, Bochicchio MT, Liverani C, Mercatali L, Calistri D, Cuneo A, Menon K, Musuraca G, Martinelli G, Simonetti G Abstract Tumor protein p53 is a key regulator of several cellular pathways, including DNA repair, cell cycle and angiogenesis. Kevetrin exhibits p53‑dependent as well as‑independent activity in solid tumors, while its effects on leukemic cells remain unknown. The aim of the present study was to ...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research