Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling.
Authors: Zhang M, Chen L, Liu Y, Chen M, Zhang S, Kong D Abstract Osteosarcoma (OS) has been demonstrated to be difficult to cure due to its potently malignant metastasis. Therefore, new therapeutic approaches blocking the metastatic potential of OS are urgently required to improve the outcomes for OS patients. In the present study, the anti‑metastatic capacity of sea cucumber (Cucumaria frondosa) fucoidan (Cf‑Fuc) was evaluated on osteosarcoma cells by cell adhesion assay, Transwell assay and U2OS cell migration assay. The underlying mechanism on the dynamic remodeling of the cytoskeleton was also explored. Th...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Girdin interaction with vimentin induces EMT and promotes the  growth and metastasis of pancreatic ductal adenocarcinoma.
Girdin interaction with vimentin induces EMT and promotes the growth and metastasis of pancreatic ductal adenocarcinoma. Oncol Rep. 2020 May 19;: Authors: Wang W, Chen H, Gao W, Wang S, Wu K, Lu C, Luo X, Li L, Yu C Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant cancer of the digestive tract that has a high potential for metastasis and a poor prognosis. Girdin was first reported in 2005 as an actin‑binding protein and was designated as Akt‑phosphorylation enhancer (APE); thus, Girdin has been revealed to have an important role in regulating cancer development. There is ...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ellagic acid induces cell cycle arrest and apoptosis via the TGF ‑β1/Smad3 signaling pathway in human colon cancer HCT‑116 cells.
Ellagic acid induces cell cycle arrest and apoptosis via the TGF‑β1/Smad3 signaling pathway in human colon cancer HCT‑116 cells. Oncol Rep. 2020 May 20;: Authors: Zhao J, Li G, Wei J, Dang S, Yu X, Ding L, Shang C, Zhang H, Zhang Z, Chen H, Liu M Abstract Colorectal carcinoma (CRC) is a major type of malignancy worldwide. Ellagic acid (EA), a natural phenolic constituent, has been shown to exhibit anticancer effects. In our previous study, it was shown that EA inhibited proliferation of CRC cells. Additionally, microarray analysis revealed 4,738 differentially expressed genes (DEGs) which were...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

UBR5 regulates proliferation and radiosensitivity in human laryngeal carcinoma via the p38/MAPK signaling pathway.
Authors: Wang K, Tang J, Liu X, Wang Y, Chen W, Zheng R Abstract Laryngeal carcinoma (LCC) is a common malignant tumor with low radiosensitivity and generally poor response rates. The ubiquitin protein ligase E3 component n‑recognin 5 (UBR5) has prognostic implications in several neoplasms; however, its role in LCC and radiotherapy sensitivity remains unknown. Immunohistochemistry and bioinformatics analyses were performed to measure UBR5 protein and mRNA expression in LCC and adjacent non‑tumor tissues. The gene and protein expression of UBR5 in LCC and HuLa‑PC cell lines were measured using quantitative PCR...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel highly frequent single ‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing.
A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing. Oncol Rep. 2020 May 19;: Authors: Yu W, Wang X, Wang Y, Jiang Y, Zhang W, Shi H, Li Y Abstract Clear cell renal cell carcinoma (CCRCC) with sarcomatoid differentiation (CCRCCS) displays invasive behavior, poor prognosis, and poor therapeutic response. The present study was aimed to gain new insights into the molecular mechanisms of sarcomatoid transformation, and identify new prognostic and therapeutic targets for CCRCCS. Whole...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TAZ is overexpressed in prostate cancers and regulates the proliferation, migration and apoptosis of prostate cancer PC3 cells.
Authors: Lin M, Bu C, He Q, Gu J, Wang H, Feng N, Jiang SW Abstract TAZ (transcriptional coactivator with PDZ‑binding motif), which is also known as WW domain‑containing transcription regulator 1 (WWTR1), a downstream effector of the Hippo pathway, has been reported to regulate cancer cell proliferation, migration and apoptosis by acting as a transcriptional coactivator. However, the function of TAZ in prostate cancer cells has not been investigated. In the present study, TAZ expression in prostate cancer (PCa) and benign prostatic hyperplasia tissues, PCa cell lines, and normal prostate epithelial cells was de...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑1299/NOTCH3/TUG1 feedback loop contributes to the malignant proliferation of ovarian cancer.
miR‑1299/NOTCH3/TUG1 feedback loop contributes to the malignant proliferation of ovarian cancer. Oncol Rep. 2020 May 25;: Authors: Pei Y, Li K, Lou X, Wu Y, Dong X, Wang W, Li N, Zhang D, Cui W Abstract Recent studies have revealed the oncogenic role of notch reporter 3 (NOTCH3) in ovarian cancer (OC). However, the possible regulators and mechanisms underlying notch receptor 3 (NOTCH3)‑mediated behaviors in OC remain to be completely investigated. In the present study, we aimed to identify regulators of NOTCH3 and their interactions underlying the pathogenesis of OC. Bioinformatics analysis and luc...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Principal component analysis on LC ‑MS/MS and 2DE‑MALDI‑TOF in glioblastoma cell lines reveals that mitochondria act as organelle sensors of the metabolic state in glioblastoma.
Principal component analysis on LC‑MS/MS and 2DE‑MALDI‑TOF in glioblastoma cell lines reveals that mitochondria act as organelle sensors of the metabolic state in glioblastoma. Oncol Rep. 2020 May 27;: Authors: Gómez-Caudillo L, Ortega-Lozano AJ, Martínez-Batallar ÁG, Rosas-Vargas H, Minauro-Sanmiguel F, Encarnación-Guevara S Abstract Glioblastoma is a difficult disease to diagnose. Proteomic techniques are commonly applied in biomedical research, and can be useful for early detection, making an accurate diagnosis and reducing mortality. The relevance of mitochondria i...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PER2 inhibits proliferation and stemness of glioma stem cells via the Wnt/ β‑catenin signaling pathway.
PER2 inhibits proliferation and stemness of glioma stem cells via the Wnt/β‑catenin signaling pathway. Oncol Rep. 2020 May 27;: Authors: Ma D, Hou L, Xia H, Li H, Fan H, Jia X, Niu Z Abstract Glioblastoma is a highly malignant tumor that contains stem‑like cells known as glioma stem cells (GSCs), which lare associated with an increased risk of glioma occurrence, recurrence and poor prognosis. Circadian clock gene, period circadian clock 2 (PER2) expression has been revealed to be inhibited in various types of cancer. However, the precise role and potential mechanisms of PER2 in GSCs remai...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Propofol suppresses the progression of non ‑small cell lung cancer via downregulation of the miR‑21‑5p/MAPK10 axis.
Propofol suppresses the progression of non‑small cell lung cancer via downregulation of the miR‑21‑5p/MAPK10 axis. Oncol Rep. 2020 May 21;: Authors: Wu X, Li X, Xu G Abstract Non‑small cell lung cancer (NSCLC) accounts for>80% of lung cancer cases and is the leading cause of cancer‑associated mortality worldwide. Propofol is an anesthetic drug frequently used during tumor resection. It is also known to exert inhibitory effects on cancer. Although the role of propofol in NSCLC has been reported, its underlying mechanisms remain unknown. The present study aimed therefore to investigate the m...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA MIAT knockdown potentiates the therapeutic effect of transcatheter arterial embolization in liver cancer by regulating the miR‑203a/HIF‑1α axis.
In conclusion, MIAT knockdown potentiated the therapeutic effect of TAE in liver cancer by regulating the miR‑203a/HIF‑1α axis in vitro and in vivo, thus expanding our understanding on the function and molecular basis of MIAT in TAE treatment for liver cancer. PMID: 32468055 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Veratramine suppresses human HepG2 liver cancer cell growth in  vitro and in vivo by inducing autophagic cell death.
Veratramine suppresses human HepG2 liver cancer cell growth in vitro and in vivo by inducing autophagic cell death. Oncol Rep. 2020 May 25;: Authors: Yin L, Xia Y, Xu P, Zheng W, Gao Y, Xie F, Ji Z Abstract Liver cancer is the second leading cause of cancer‑related deaths. Traditional therapeutic strategies, such as chemotherapy, targeted therapy and interventional therapy, are inefficient and are accompanied by severe side effects for patients with advanced liver cancer. Therefore, it is crucial to develop a safer more effective drug to treat liver cancer. Veratramine, a known natural steroidal...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Supervillin promotes tumor angiogenesis in liver cancer.
Authors: Zhao C, Zhao Z, Wang Z, Hu L, Wang H, Fang Z Abstract Tumor angiogenesis is a hallmark of liver cancer and is necessary for tumor growth and progression. Supervillin (SVIL) is highly expressed and implicated in several malignant processes of liver cancer. However, the functional relationships between SVIL and tumor angiogenesis in liver cancer have not yet been fully elucidated. The present study was based on bioinformatics analysis, patient tissue sample detection, three‑dimensional simulated blood vessel formation, a series of cytological experiments and mouse models. The results demonstrated the impor...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Bioinformatics analysis of the network of histone H3 lysine 9 trimethylation in acute myeloid leukaemia.
Authors: Dong A, Yang W, Huang H, Zhou X, He Z, Yao R, Guo W Abstract Changes in histone H3 lysine 9 trimethylation (H3K9me3) may be related to the development of drug‑resistant acute myeloid leukaemia (AML); insights into the network of H3K9me3 may improve patient prognosis. Patient data were derived from the Gene Expression Omnibus (GEO) database and data from AML cells treated with chidamide, a novel benzamide chemical class of histone deacetylase inhibitor (HDACi), in vitro were derived from ChIP‑seq. Patients and AML cell data were analysed using GEO2R, GOseq, KOBAS, the STRING database and Cytoscape ...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.
Authors: Guo D, Li F, Zhao X, Long B, Zhang S, Wang A, Cao D, Sun J, Li B Abstract Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Circular RNAs (circRNAs) are a novel class of RNAs, with higher stability and tissue specificity, which may be of value as novel clinical markers. High‑throughput RNA sequencing was used to profile the expression of circRNAs in 5 pairs of cancer and normal tissues, and reverse transcription‑quantitative PCR (RT‑qPCR) analysis was employed to verify the results of the RNA sequencing in 45 cases of PTC. The dysregulated circRNA expression and clinic...
Source: Oncology Reports - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

NEAT1 knockdown suppresses endothelial cell proliferation and induces apoptosis by regulating miR ‑638/AKT/mTOR signaling in atherosclerosis.
NEAT1 knockdown suppresses endothelial cell proliferation and induces apoptosis by regulating miR‑638/AKT/mTOR signaling in atherosclerosis. Oncol Rep. 2020 May 07;: Authors: Zhang X, Guan MX, Jiang QH, Li S, Zhang HY, Wu ZG, Cong HL, Qi XH Abstract Long non‑coding RNAs (lncRNAs) have been validated to mediate the development of atherosclerosis (AS). In the present study, the molecular mechanisms and functions of lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) in the advancement of human aortic endothelial cells (HAECs) were investigated. The levels of lncRNA‑NEAT1 and miR‑638 exp...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

1 ‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells.
1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells. Oncol Rep. 2020 Apr 28;: Authors: Yang KH, Kim GT, Choi S, Yoon SY, Kim JW Abstract Activated epidermal growth factor receptors (EGFRs) are crucial for inducing metastasis in cancer cells by promoting matrix metalloproteinase (MMP) expression. The present study was designed to investigate the effects of 1‑palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol (PLAG) on MMP expression in epidermal growth factor (EGF)‑stimulated ...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hsp90 inhibitor 17 ‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway.
Hsp90 inhibitor 17‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway. Oncol Rep. 2020 Apr 28;: Authors: Shu X, Liu H, Zhen R, Jie Y, Chen L, Qi H, Wang C, Wang R, Chen D, Ran Y Abstract Multiple drug resistance is a major obstacle to the successful treatment of osteosarcoma (OS). Recent studies have demonstrated that a subset of cells, referred to as OS stem cells (OSCs), play a crucial role in the acquisition of multiple drug resistance. Therefore, an improved understanding of OS biology and pathogenesis is required to advance the d...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

VL30 retrotransposition is associated with induced EMT, CSC generation and tumorigenesis in HC11 mouse mammary stem ‑like epithelial cells.
VL30 retrotransposition is associated with induced EMT, CSC generation and tumorigenesis in HC11 mouse mammary stem‑like epithelial cells. Oncol Rep. 2020 Apr 28;: Authors: Thrasyvoulou S, Vartholomatos G, Markopoulos G, Noutsopoulos D, Mantziou S, Gkartziou F, Papageorgis P, Charchanti A, Kouklis P, Constantinou AI, Tzavaras T Abstract Retrotransposons copy their sequences via an RNA intermediate, followed by reverse transcription into cDNA and random insertion, into a new genomic locus. New retrotransposon copies may lead to cell transformation and/or tumorigenesis through insertional mutagenesis. ...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of the natural compound trans ‑resveratrol on human MCM4 gene transcription.
Effect of the natural compound trans‑resveratrol on human MCM4 gene transcription. Oncol Rep. 2020 Apr 28;: Authors: Uchiumi F, Katsuda C, Akui M, Kusaka M, Tanaka M, Asai M, Tanuma SI Abstract trans‑Resveratrol (Rsv) is a natural compound contained in red wine and grape skins that has various beneficial effects for organisms such as lengthening of their life span. Rsv induces expression of the human TP53 and HELB genes, which are involved in the regulation of DNA maintenance. In the present study, a luciferase expression vector containing 309 bp of the 5' upstream end of the human MCM4 gene w...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑193b exhibits mutual interaction with MYC, and suppresses growth and metastasis of osteosarcoma.
miR‑193b exhibits mutual interaction with MYC, and suppresses growth and metastasis of osteosarcoma. Oncol Rep. 2020 Apr 29;: Authors: Gao J, Ma S, Yang F, Chen X, Wang W, Zhang J, Li Y, Wang T, Shan L Abstract Emerging evidence has indicated that microRNAs (miRs) are involved in the malignant behavior of cancer. The present study explored the role of miR‑193b in the development and metastasis of osteosarcoma. Compared with F4 osteosarcoma cells, which have a relatively low metastatic potential, highly metastatic F5M2 cells exhibited a lower expression of miR‑193b. Furthermore, miR‑193b exerted...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ciprofloxacin promotes polarization of CD86+CD206 ‑ macrophages to suppress liver cancer.
In conclusion, the findings of the present study indicated that ciprofloxacin may inhibit liver cancer by upregulating the expression of CD86+CD206‑ macrophages. This study further revealed the biological mechanism underlying the potential value of ciprofloxacin in antitumor therapy and provided new targets for the treatment of liver cancer. PMID: 32377744 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor ‑stromal crosstalk under hypoxic conditions via the IL‑6/ERK/NF‑κB axis.
Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor‑stromal crosstalk under hypoxic conditions via the IL‑6/ERK/NF‑κB axis. Oncol Rep. 2020 Apr 28;: Authors: Li W, Sun L, Lei J, Wu Z, Ma Q, Wang Z Abstract Hypoxic microenvironment and pancreatic stellate cells (PSCs) play important roles in pancreatic cancer progression. PSCs secrete a number of soluble factors, such as interleukin (IL)‑6, to facilitate cancer metastasis. Our previous study revealed that curcumin inhibited the invasive ability of pancreatic cancer cells by modulating epithelial‑to‑mesen...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Kindlin ‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction.
Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction. Oncol Rep. 2020 May 04;: Authors: Wu G, Long Y, Lu Y, Feng Y, Yang X, Xu X, Yao D Abstract Kindlin‑2 plays a carcinogenic or tumor‑suppressor role in various tumors. However, its role in cervical cancer remains unclear. In the present study, kindlin‑2 expression was first analyzed using public expression data and clinical specimens. It was revealed that kindlin‑2 was downregulated in cervical cancer tissues, and low expression of kindlin‑2 was associated with poor disease‑free survival. In...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Morpho ‑functional study of the hypothalamic proline‑rich polypeptide apoptotic activity against mouse Ehrlich ascites carcinoma.
Morpho‑functional study of the hypothalamic proline‑rich polypeptide apoptotic activity against mouse Ehrlich ascites carcinoma. Oncol Rep. 2020 May 04;: Authors: Abrahamyan S, Sahakyan I, Tumasyan N, Kocharyan N, Simonyan A, Aroutiounian R, Chailyan G, Chailyan S, Davtyan T, Galoian K Abstract A new type of bioactive polypeptides of the neurosecretory hypothalamus called proline‑rich peptides (PRPs), which are isolated from bovine neurosecretory granules of the neurohypophysis, are synthesized in the form of a common precursor protein (neurophysin vasopressin‑associated glycoprotein). Proline...
Source: Oncology Reports - May 8, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Estrogen promotes the metastasis of non ‑small cell lung cancer via estrogen receptor β by upregulation of Toll‑like receptor 4 and activation of the myd88/NF‑κB/MMP2 pathway.
Estrogen promotes the metastasis of non‑small cell lung cancer via estrogen receptor β by upregulation of Toll‑like receptor 4 and activation of the myd88/NF‑κB/MMP2 pathway. Oncol Rep. 2020 Apr 02;: Authors: Fan S, Liao Y, Qiu W, Huang Q, Xiao H, Liu C, Li D, Cao X, Li L, Liang H, Ai B, Zhou S Abstract Estrogen promotes non‑small cell lung cancer (NSCLC) metastasis via estrogen receptor β (ERβ)‑mediated invasiveness‑associated matrix metalloprotease 2 (MMP2) upregulation. However, how ERβ increases the aggressiveness of NSCLC cells remains unclear. ...
Source: Oncology Reports - May 5, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Targeted deep sequencing contributes to guiding personalized targeted therapy for advanced biliary tract cancer patients with non ‑radical resection: A real‑world study.
Targeted deep sequencing contributes to guiding personalized targeted therapy for advanced biliary tract cancer patients with non‑radical resection: A real‑world study. Oncol Rep. 2020 Feb 06;: Authors: Feng F, Cheng Q, Zhang D, Li B, Qin H, Xu C, Han M, Yu Y, Li Z, Li JY, Qiu Z, Xiong L, Liu C, Li F, Yi B, Jiang X Abstract Targeted therapy based on specific genetic alterations has been proven to be an effective treatment for various types of cancer. In the present study, we aimed to explore the efficacy of personalized targeted therapy guided by targeted deep sequencing for patients with advanced ...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2 ‑UDP glucuronosyltransferase 1A metabolic axis activation.
Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation. Oncol Rep. 2020 Feb 10;: Authors: Hao Q, Wang M, Sun NX, Zhu C, Lin YM, Li C, Liu F, Zhu WW Abstract The long pre‑cancerous state of colorectal cancer (CRC) provides an opportunity to prevent the occurrence and development of CRC. The detoxification of CRC food‑borne carcinogenic heterocyclic amines is highly dependent on UDP glucuronosyltransferase 1A (UGT1A)‑mediated glucuronidation. Sulforaphane (SFN), a phytochemical, possesses antioxidant, anti‑i...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Activation of NLRP3 inflammasome promotes the proliferation and migration of esophageal squamous cell carcinoma.
Authors: Yu S, Yin JJ, Miao JX, Li SG, Huang CZ, Huang N, Fan TL, Li XN, Wang YH, Han SN, Zhang LR Abstract Inflammasomes can identify endogenous danger signals as an inflammatory immune response. As the most common inflammasome, the NLR pyrin family domain containing 3 (NLRP3) inflammasome is associated with the pathogenesis of different tumors. However, the function of the NLRP3 inflammasome in esophageal cancer (EC) has rarely been reported. Herein, the expression levels of the components of NLRP3 inflammasome and Ki‑67 were analyzed by immunohistochemistry. Furthermore, correlations between the NLRP...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
In conclusion, downregulation of the PI3K/Akt/mTOR pathway was shown to assist in the process of preventing chemoresistance. PMID: 32323781 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of MMP ‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT.
Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT. Oncol Rep. 2020 Feb 06;: Authors: Wang K, Zheng J, Yu J, Wu Y, Guo J, Xu Z, Sun X Abstract The present study aimed to investigate the role of matrix metalloproteinase‑1 (MMP‑1) in the development of colorectal cancer and reveal the mechanism underlying this progression. Bioinformatics methods and a public dataset were first used to analyze MMP‑1 gene expression in a public dataset. MMP‑1 expression in colorectal cancer patients was assessed by immunohistochemistry; i...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Catalpol ‑mediated microRNA‑34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer.
In conclusion, miR‑34a is involved in regulating catalpol‑mediated autophagy and malignant behavior by directly inhibiting SIRT1 in CRC. PMID: 32323786 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Epigenetic control of the EWS ‑FLI1 promoter in Ewing's sarcoma.
Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma. Oncol Rep. 2020 Feb 05;: Authors: Montoya C, Rey L, Rodríguez J, Fernández MJ, Troncoso D, Cañas A, Moreno O, Henríquez B, Rojas A Abstract Ewing sarcoma (ES) is a primary bone marrow tumor that very rarely develops in extra‑osseous tissues, such as lung. The hallmark of ES tumors is a translocation between chromosomes 11 and 22, resulting in a fusion protein, commonly referred to as EWS‑FLI1. The epigenetic profile (histone acetylation and methylation enrichment of the promoter region) that may regulate t...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA LINC00858 promotes TP53‑wild‑type colorectal cancer progression by regulating the microRNA‑25‑3p/SMAD7 axis.
Long non‑coding RNA LINC00858 promotes TP53‑wild‑type colorectal cancer progression by regulating the microRNA‑25‑3p/SMAD7 axis. Oncol Rep. 2020 Feb 18;: Authors: Zhan J, Tong J, Fu Q Abstract Long non‑coding RNAs (lncRNAs) are involved in colorectal cancer (CRC) progression, however the mechanisms remain largely unknown. The present study aimed to reveal the role and possible molecular mechanisms of a new LNCRNA, LINC00858, in CRC. LINC00858 was increased in CRC tumor tissues, and patients with high LINC00858 expression had a shorter survival time. Knockdown of LINC00858 expression suppres...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑95 promotes osteosarcoma growth by targeting SCNN1A.
miR‑95 promotes osteosarcoma growth by targeting SCNN1A. Oncol Rep. 2020 Feb 24;: Authors: Geng Y, Zhao S, Jia Y, Xia G, Li H, Fang Z, Zhang Q, Tian R Abstract Osteosarcoma (OS) is a common malignant bone tumor, presenting particularly in children and young adults, and accounts for approximately 19% of all malignant bone cancers. Despite advances in OS treatment, long‑term prognosis remains poor. miRNAs are non‑coding single‑stranded RNAs ~22 nucleotides in length. Increasing evidence suggests that numerous miRNAs may play critical roles in tumorigenesis and tumor progression; however, the role...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Single ‑cell RNA sequencing of t(8;21) acute myeloid leukemia for risk prediction.
Single‑cell RNA sequencing of t(8;21) acute myeloid leukemia for risk prediction. Oncol Rep. 2020 Feb 18;: Authors: Xiong Q, Huang S, Li YH, Lv N, Lv C, Ding Y, Liu WW, Wang LL, Chen Y, Sun L, Zhao Y, Liao SY, Zhang MQ, Zhu BL, Yu L Abstract Single‑cell RNA sequencing (scRNA‑seq) of bone marrow or peripheral blood samples from patients with acute myeloid leukemia (AML) enables the characterization of heterogeneous malignant cells. A total of 87 cells from two patients with t(8;21) AML were analyzed using scRNA‑seq. Clustering methods were used to separate leukemia cells into different sub...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Oroxylin  A exerts anticancer effects on human ovarian cancer cells via the PPARγ‑dependent reversal of the progesterone receptor membrane component 1/2 expression profile.
Oroxylin A exerts anticancer effects on human ovarian cancer cells via the PPARγ‑dependent reversal of the progesterone receptor membrane component 1/2 expression profile. Oncol Rep. 2020 Feb 21;: Authors: Shen JJ, Zhu XF, Xu J, Wang ZF, Gu WJ, Chen Y Abstract Ovarian cancer is the most lethal gynecological cancer worldwide. To date, the therapeutic approaches available for the treatment of ovarian cancer are still very limited. The present study first demonstrated that the Chinese herb, Oroxylin A, exerts inhibitory effects on both the migratory ability and viability of ovarian cancer cel...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

AREG mediates the epithelial ‑mesenchymal transition in pancreatic cancer cells via the EGFR/ERK/NF‑κB signalling pathway.
AREG mediates the epithelial‑mesenchymal transition in pancreatic cancer cells via the EGFR/ERK/NF‑κB signalling pathway. Oncol Rep. 2020 Feb 27;: Authors: Wang L, Wang L, Zhang H, Lu J, Zhang Z, Wu H, Liang Z Abstract Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. The biological roles of AREG in the regulation of the epithelial‑mesenchymal transition (EMT) in pancreatic cancer remain unclear. To investigate the expression of epidermal growth factor receptor (EGFR) and AREG in pancreatic cancer cell lines, RT‑qPCR, we...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA TPTEP1 competitively sponges miR ‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells.
lncRNA TPTEP1 competitively sponges miR‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells. Oncol Rep. 2020 Feb 26;: Authors: Cao F, Wang Z, Feng Y, Zhu H, Yang M, Zhang S, Wang X Abstract Accumulating evidence suggests that lncRNAs are involved in almost all normal physiological processes and that aberrant expression of lncRNAs may be involved in the development of diseases, including non‑small cell lung cancer (NSCLC). However, the roles of lncRNA‑TPTE pseudogene 1 (TPTEP1) in lung cancer and the underlying molecular mechanisms have remained elusive. In the present...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PLC ε knockdown enhances the radiosensitivity of castration‑resistant prostate cancer via the AR/PARP1/DNA‑PKcs axis.
PLCε knockdown enhances the radiosensitivity of castration‑resistant prostate cancer via the AR/PARP1/DNA‑PKcs axis. Oncol Rep. 2020 Feb 26;: Authors: Pu J, Li T, Liu N, Luo C, Quan Z, Li L, Wu X Abstract Radiotherapy (RT) has been used as a therapeutic option for treatment of prostate cancer (PCa) for a number of years; however, patients frequently develop RT resistance, particularly in castration‑resistant PCa (CRPC), although the underlying mechanisms remain unknown. Understanding the underlying mechanism of RT resistance in CRPC may potentially highlight novel targets to improve thera...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ORP8 induces apoptosis by releasing cytochrome  c from mitochondria in non‑small cell lung cancer.
ORP8 induces apoptosis by releasing cytochrome c from mitochondria in non‑small cell lung cancer. Oncol Rep. 2020 Feb 24;: Authors: Li J, Cui J, Li Z, Fu X, Li J, Li H, Wang S, Zhang M Abstract Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer, and numerous oncogenes are associated with this disease. Oxysterol‑binding protein‑related protein 8 (ORP8) is essential for cell growth, migration and the modulation of mitochondrial respiration and morphology. However, the underlying role of ORP8 in NSCLC remains unclear. In the present study, it was reported that the ...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

METTL14 promotes the migration and invasion of breast cancer cells by modulating N6 ‑methyladenosine and hsa‑miR‑146a‑5p expression.
METTL14 promotes the migration and invasion of breast cancer cells by modulating N6‑methyladenosine and hsa‑miR‑146a‑5p expression. Oncol Rep. 2020 Feb 24;: Authors: Yi D, Wang R, Shi X, Xu L, Yilihamu Y, Sang J Abstract Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer‑related death among women worldwide. Evidence indicates that posttranscriptional N6‑methyladenosine (m6A) modification modulates BC development. In the present study, we assessed BC and normal tissues to investigate this connection. RNA m6A levels were determined by methylation quanti...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cutoff of 25% for Ki67 expression is a good classification tool for prognosis in colorectal cancer in the AJCC ‑8 stratification.
Cutoff of 25% for Ki67 expression is a good classification tool for prognosis in colorectal cancer in the AJCC‑8 stratification. Oncol Rep. 2020 Feb 21;: Authors: Tong G, Zhang G, Liu J, Zheng Z, Chen Y, Niu P, Xu X Abstract Ki‑67 expression has been widely used in clinical practice as an index to evaluate the proliferative activity of tumor cells. The cutoff for Ki67 expression in order to increase the prognostic value of Ki67 expression in colorectal cancer varies. The present study assessed the relationship between the 25% cutoff for Ki67 expression and prognosis in colorectal cancer in the AJCC...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

N6 ‑methyladenosine RNA methylation regulators participate in malignant progression and have prognostic value in clear cell renal cell carcinoma.
N6‑methyladenosine RNA methylation regulators participate in malignant progression and have prognostic value in clear cell renal cell carcinoma. Oncol Rep. 2020 Feb 28;: Authors: Zheng Z, Mao S, Guo Y, Zhang W, Liu J, Li C, Yao X Abstract N6‑methyladenosine (m6A) RNA methylation is the most prevalent type of mRNA modification; however, little is known about its function in clear cell renal cell carcinoma (ccRCC). The present study aimed to establish and validate a m6A‑related risk signature as a prognostic factor for patients with ccRCC. Consensus clustering was used to divide patients with ccRCC...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

GSK ‑3 inhibitor CHIR99021 enriches glioma stem‑like cells.
GSK‑3 inhibitor CHIR99021 enriches glioma stem‑like cells. Oncol Rep. 2020 Feb 28;: Authors: Yang Y, Wang QQ, Bozinov O, Xu RX, Sun YL, Wang SS Abstract Glioblastoma (GBM) is the most prevalent and lethal primary intrinsic brain cancer. The disease is essentially incurable, with glioblastomas characterized by resistance to both chemotherapy and radiotherapy, as well as by rapid tumor progression, all of which are mainly ascribed to glioma stem‑like cells (GSLCs). In the present study, an improved model that is more similar to clinical GBM was constructed. Twenty clinical glioma samples were colle...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

p62 promotes proliferation, apoptosis ‑resistance and invasion of prostate cancer cells through the Keap1/Nrf2/ARE axis.
p62 promotes proliferation, apoptosis‑resistance and invasion of prostate cancer cells through the Keap1/Nrf2/ARE axis. Oncol Rep. 2020 Feb 28;: Authors: Jiang G, Liang X, Huang Y, Lan Z, Zhang Z, Su Z, Fang Z, Lai Y, Yao W, Liu T, Hu, Wang F, Huang H, Liu L, Jiang X Abstract Prostate cancer poses a public health threat to hundreds of people around the world. p62 has been identified as a tumor suppressor, however, the mechanism by which p62 promotes prostate cancer remains poorly understood. The present study aimed to investigate whether p62 promotes proliferation, apoptosis resistance and invasion o...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

α‑Solanine inhibits growth and metastatic potential of human colorectal cancer cells.
α‑Solanine inhibits growth and metastatic potential of human colorectal cancer cells. Oncol Rep. 2020 Feb 26;: Authors: Yan X, Li M, Chen L, Peng X, Que ZJ, An HM, Shen KP, Hu B Abstract Solanum nigrum L. (Longkui) is one the most widely used anticancer herbs in traditional Chinese medicine. α‑Solanine is an important ingredient of S. nigrum L. and has demonstrated anticancer properties in various types of cancer. However, the effects of α‑solanine on colorectal cancer remain elusive. The aim of the present study was to assess the effects of α‑solanine on human...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑126‑3p suppresses HeLa cell proliferation, migration and invasion, and increases apoptosis via the PI3K/PDK1/AKT pathway.
MicroRNA‑126‑3p suppresses HeLa cell proliferation, migration and invasion, and increases apoptosis via the PI3K/PDK1/AKT pathway. Oncol Rep. 2020 Feb 21;: Authors: Ichikawa R, Kawasaki R, Iwata A, Otani S, Nishio E, Nomura H, Fujii T Abstract We previously reported that relative to normal cervical mucus, microRNA 126‑3p (miR‑126‑3p) is present in significantly greater amounts in the cervical mucus of patients with overt cervical cancer or precursor lesions. Here, we investigated the effects of enforced miR‑126‑3p expression in the cervical cancer cell line, HeLa, on proliferation, migrat...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples.
Authors: Dong S, Men W, Yang S, Xu S Abstract Lung adenocarcinoma is one of the most common malignant tumors worldwide. Although efforts have been made to clarify its pathology, the underlying molecular mechanisms of lung adenocarcinoma are still not clear. The microarray datasets GSE75037, GSE63459 and GSE32863 were downloaded from the Gene Expression Omnibus (GEO) database to identify biomarkers for effective lung adenocarcinoma diagnosis and therapy. The differentially expressed genes (DEGs) were identified by GEO2R, and function enrichment analyses were conducted using the Kyoto Encyclopedia of Genes and Genome...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cold atmospheric plasma ‑activated Ringer's solution inhibits the proliferation of osteosarcoma cells through the mitochondrial apoptosis pathway.
Cold atmospheric plasma‑activated Ringer's solution inhibits the proliferation of osteosarcoma cells through the mitochondrial apoptosis pathway. Oncol Rep. 2020 Feb 25;: Authors: Xu S, Wang Y, Que Y, Ma C, Cai S, Wang H, Yang X, Yang C, Cheng C, Zhao G, Hu Y Abstract The present study aimed to investigate the effects of cold atmospheric plasma (CAP)‑activated Ringer's solution on osteosarcoma cell lines MG63 and U2OS, and to identify the molecular mechanism underlying these effects. CAP‑activated Ringer's solution was used to treat osteosarcoma cell lines MG63 and U2OS for 30 min. Cell viab...
Source: Oncology Reports - April 25, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research