Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression
Oncol Rep. 2024 Feb;51(2):27. doi: 10.3892/or.2023.8686. Epub 2023 Dec 22.ABSTRACTUrsolic acid (UA), a natural pentacyclic triterpenoid, is known to exhibit various biological activities and anticancer effects. However, the underlying anticancer mechanism is not fully understood to date. The present study aimed to investigate the antimetastatic effect of UA through ADP‑ribosylation factor like GTPase 4C (ARL4C) in colon cancer. A lung metastasis model of colon cancer in nude mice was established through tail vein injection. A Cell Counting Kit‑8 assay was used to investigate the proliferation of colon cancer cells. Tra...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Mengzhe Zhang Fenfen Xiang Yipeng Sun Rongrong Liu Qian Li Qing Gu Xiangdong Kang Rong Wu Source Type: research
Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review)
Oncol Rep. 2024 Feb;51(2):19. doi: 10.3892/or.2023.8678. Epub 2023 Dec 15.ABSTRACTGastrointestinal cancer is frequently detected at an advanced stage and has an undesirable prognosis due to the absence of efficient and precise biomarkers and therapeutic targets. Exosomes are small, living‑cell‑derived vesicles that serve a critical role in facilitating intercellular communication by transporting molecules from donor cells to receiver cells. circular RNAs (circRNAs) are mis‑expressed in a variety of diseases, including gastrointestinal cancer, and are promising as diagnostic biomarkers and tumor therapeutic targets fo...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Yumeng Xu Jiayi Han Xuan Zhang Xinyi Zhang Jiajia Song Zihan Gao Hui Qian Jianhua Jin Zhaofeng Liang Source Type: research
Inhibitor of Wnt receptor 1 suppresses the effects of Wnt1, Wnt3a and β‑catenin on the proliferation and migration of C6 GSCs induced by low‑dose radiation
Oncol Rep. 2024 Feb;51(2):22. doi: 10.3892/or.2023.8681. Epub 2023 Dec 15.ABSTRACTThe radioresistance of glioma is an important cause of treatment failure and tumor aggressiveness. In the present study, under performed with linear accelerator, the effects of 0.3 and 3.0 Gy low‑dose radiation (LDR) on the proliferation and migration of C6 glioma stem cells in vitro were examined by flow cytometric analysis, immunocytochemistry and western blot analysis. It was found that low‑dose ionizing radiation (0.3 Gy) stimulated the proliferation and migration of these cells, while 3.0 Gy ionizing radiation inhibited the prolifera...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Yu Yan Ying-Ying Cheng Yan-Ru Li Xu-Wen Jiao Yin-Ming Liu Hai-Yan Cai Yin-Xiu Ding Source Type: research
G protein ‑mediated EGFR transactivation is a common mechanism through which the CXCL12 receptors, CXCR4 and CXCR7, control human cancer cell migration
In conclusion, the results of the present study suggest that G protein‑ and Src‑dependent transactivation of EGFR is a common mechanism through which CXCL12‑bound CXCR4 and/or CXCR7 control cancer cell migration and metastasis. These findings highlight EGFR as a potential therapeutic target that interferes with CXCL12‑induced cancer expansion.PMID:38099418 | DOI:10.3892/or.2023.8683 (Source: Oncology Reports)
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Konstanze Zieger-Naumann Frederike Kuhl J ürgen Engele Source Type: research
[Retracted] miR ‑141 inhibits prostatic cancer cell proliferation and migration, and induces cell apoptosis via targeting of RUNX1
Oncol Rep. 2024 Feb;51(2):20. doi: 10.3892/or.2023.8679. Epub 2023 Dec 15.ABSTRACTFollowing the publication of the above paper, a concerned reader drew to the Editor's attention that a number of plates showing colony formation assay data in Fig. 3A appeared to be overlapping, such that data purportedly showing the results from differently performed experiments may have been derived from the same original source(s); furthermore, certain of the cell‑cycle histograms shown in Fig. 4B were duplicated, again where they were intended to have shown results obtained under different experimental conditions. Subsequently, followin...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Song Xu Jingping Ge Zhengyu Zhang Wenquan Zhou Source Type: research
Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma
The objective of the present study was to examine the ability of caffeic acid phenethyl ester (CAPE), which is an active compound found in propolis, to combat HSCC tumor growth. CAPE exerted its tumor‑suppressive activity in HSCC cell lines through the induction of apoptosis. Mechanistically, the CAPE‑mediated apoptotic process was attributed to the perturbation of the mitochondrial membrane potential and the activation of caspase‑9. CAPE also modulated survivin and X‑linked inhibitor of apoptosis, which are potent members of the inhibitors of apoptosis protein family, either through transcriptional or post‑trans...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Hyun-Ji Kim Min-Hye Ahn Ji-Ae Shin Su-Jung Choi Hyun-Ju Yu Sung-Dae Cho Source Type: research
STING promotes invasion and migration of uveal melanoma through p38 ‑MAPK signaling
Oncol Rep. 2024 Feb;51(2):23. doi: 10.3892/or.2023.8682. Epub 2023 Dec 15.ABSTRACTUveal melanoma (UM) is the most common intraocular malignant tumor in adults, with a lack of effective treatment for metastasis and a poor prognosis. Stimulator of interferon genes (STING, also known as TMEM173) plays an important role in tumor development by regulating cell proliferation, metastasis and other cellular processes. However, the function of STING in UM remains unclear and requires further investigation. The present study analyzed the expression status of STING to elucidate the mechanisms underlying UM. The correlation between ST...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Xiaoting Zhou Fengxi Meng Binbin Xu Ruiqi Ma Yun Cheng Jihong Wu Jiang Qian Source Type: research
Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review)
Oncol Rep. 2024 Feb;51(2):19. doi: 10.3892/or.2023.8678. Epub 2023 Dec 15.ABSTRACTGastrointestinal cancer is frequently detected at an advanced stage and has an undesirable prognosis due to the absence of efficient and precise biomarkers and therapeutic targets. Exosomes are small, living‑cell‑derived vesicles that serve a critical role in facilitating intercellular communication by transporting molecules from donor cells to receiver cells. circular RNAs (circRNAs) are mis‑expressed in a variety of diseases, including gastrointestinal cancer, and are promising as diagnostic biomarkers and tumor therapeutic targets fo...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Yumeng Xu Jiayi Han Xuan Zhang Xinyi Zhang Jiajia Song Zihan Gao Hui Qian Jianhua Jin Zhaofeng Liang Source Type: research
Inhibitor of Wnt receptor 1 suppresses the effects of Wnt1, Wnt3a and β‑catenin on the proliferation and migration of C6 GSCs induced by low‑dose radiation
Oncol Rep. 2024 Feb;51(2):22. doi: 10.3892/or.2023.8681. Epub 2023 Dec 15.ABSTRACTThe radioresistance of glioma is an important cause of treatment failure and tumor aggressiveness. In the present study, under performed with linear accelerator, the effects of 0.3 and 3.0 Gy low‑dose radiation (LDR) on the proliferation and migration of C6 glioma stem cells in vitro were examined by flow cytometric analysis, immunocytochemistry and western blot analysis. It was found that low‑dose ionizing radiation (0.3 Gy) stimulated the proliferation and migration of these cells, while 3.0 Gy ionizing radiation inhibited the prolifera...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Yu Yan Ying-Ying Cheng Yan-Ru Li Xu-Wen Jiao Yin-Ming Liu Hai-Yan Cai Yin-Xiu Ding Source Type: research
G protein ‑mediated EGFR transactivation is a common mechanism through which the CXCL12 receptors, CXCR4 and CXCR7, control human cancer cell migration
In conclusion, the results of the present study suggest that G protein‑ and Src‑dependent transactivation of EGFR is a common mechanism through which CXCL12‑bound CXCR4 and/or CXCR7 control cancer cell migration and metastasis. These findings highlight EGFR as a potential therapeutic target that interferes with CXCL12‑induced cancer expansion.PMID:38099418 | DOI:10.3892/or.2023.8683 (Source: Oncology Reports)
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Konstanze Zieger-Naumann Frederike Kuhl J ürgen Engele Source Type: research
[Retracted] miR ‑141 inhibits prostatic cancer cell proliferation and migration, and induces cell apoptosis via targeting of RUNX1
Oncol Rep. 2024 Feb;51(2):20. doi: 10.3892/or.2023.8679. Epub 2023 Dec 15.ABSTRACTFollowing the publication of the above paper, a concerned reader drew to the Editor's attention that a number of plates showing colony formation assay data in Fig. 3A appeared to be overlapping, such that data purportedly showing the results from differently performed experiments may have been derived from the same original source(s); furthermore, certain of the cell‑cycle histograms shown in Fig. 4B were duplicated, again where they were intended to have shown results obtained under different experimental conditions. Subsequently, followin...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Song Xu Jingping Ge Zhengyu Zhang Wenquan Zhou Source Type: research
Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma
The objective of the present study was to examine the ability of caffeic acid phenethyl ester (CAPE), which is an active compound found in propolis, to combat HSCC tumor growth. CAPE exerted its tumor‑suppressive activity in HSCC cell lines through the induction of apoptosis. Mechanistically, the CAPE‑mediated apoptotic process was attributed to the perturbation of the mitochondrial membrane potential and the activation of caspase‑9. CAPE also modulated survivin and X‑linked inhibitor of apoptosis, which are potent members of the inhibitors of apoptosis protein family, either through transcriptional or post‑trans...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Hyun-Ji Kim Min-Hye Ahn Ji-Ae Shin Su-Jung Choi Hyun-Ju Yu Sung-Dae Cho Source Type: research
STING promotes invasion and migration of uveal melanoma through p38 ‑MAPK signaling
Oncol Rep. 2024 Feb;51(2):23. doi: 10.3892/or.2023.8682. Epub 2023 Dec 15.ABSTRACTUveal melanoma (UM) is the most common intraocular malignant tumor in adults, with a lack of effective treatment for metastasis and a poor prognosis. Stimulator of interferon genes (STING, also known as TMEM173) plays an important role in tumor development by regulating cell proliferation, metastasis and other cellular processes. However, the function of STING in UM remains unclear and requires further investigation. The present study analyzed the expression status of STING to elucidate the mechanisms underlying UM. The correlation between ST...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Xiaoting Zhou Fengxi Meng Binbin Xu Ruiqi Ma Yun Cheng Jihong Wu Jiang Qian Source Type: research
Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review)
Oncol Rep. 2024 Feb;51(2):19. doi: 10.3892/or.2023.8678. Epub 2023 Dec 15.ABSTRACTGastrointestinal cancer is frequently detected at an advanced stage and has an undesirable prognosis due to the absence of efficient and precise biomarkers and therapeutic targets. Exosomes are small, living‑cell‑derived vesicles that serve a critical role in facilitating intercellular communication by transporting molecules from donor cells to receiver cells. circular RNAs (circRNAs) are mis‑expressed in a variety of diseases, including gastrointestinal cancer, and are promising as diagnostic biomarkers and tumor therapeutic targets fo...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Yumeng Xu Jiayi Han Xuan Zhang Xinyi Zhang Jiajia Song Zihan Gao Hui Qian Jianhua Jin Zhaofeng Liang Source Type: research
Inhibitor of Wnt receptor 1 suppresses the effects of Wnt1, Wnt3a and β‑catenin on the proliferation and migration of C6 GSCs induced by low‑dose radiation
Oncol Rep. 2024 Feb;51(2):22. doi: 10.3892/or.2023.8681. Epub 2023 Dec 15.ABSTRACTThe radioresistance of glioma is an important cause of treatment failure and tumor aggressiveness. In the present study, under performed with linear accelerator, the effects of 0.3 and 3.0 Gy low‑dose radiation (LDR) on the proliferation and migration of C6 glioma stem cells in vitro were examined by flow cytometric analysis, immunocytochemistry and western blot analysis. It was found that low‑dose ionizing radiation (0.3 Gy) stimulated the proliferation and migration of these cells, while 3.0 Gy ionizing radiation inhibited the prolifera...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Yu Yan Ying-Ying Cheng Yan-Ru Li Xu-Wen Jiao Yin-Ming Liu Hai-Yan Cai Yin-Xiu Ding Source Type: research
