Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration ‑resistant prostate cancer cells
Oncol Rep. 2024 May;51(5):71. doi: 10.3892/or.2024.8730. Epub 2024 Apr 5.ABSTRACTCancer cells are characterized by increased glycolysis, known as the Warburg effect, which leads to increased production of cytotoxic methylglyoxal (MGO) and apoptotic cell death. Cancer cells often activate the protective nuclear factor erythroid 2‑related factor2 (Nrf2)/glyoxalase1 (Glo1) system to detoxify MGO. The effects of sodium butyrate (NaB), a product of gut microbiota, on Nrf2/Glos/MGO pathway and the underlying mechanisms in prostate cancer (PCa) cells were investigated in the present study. Treatment with NaB induced the cell de...
Source: Oncology Reports - April 5, 2024 Category: Cancer & Oncology Authors: Yi-Jan Hsia Zhang-Min Lin Taolan Zhang Tz-Chong Chou Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
LPCAT1 promotes melanoma cell proliferation via Akt signaling
Oncol Rep. 2024 May;51(5):67. doi: 10.3892/or.2024.8726. Epub 2024 Mar 29.ABSTRACTMelanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present st...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Yuqian Wang Yingjian Huang Yan Wang Wen Zhang Ning Wang Ruimin Bai Ruiting Luo Huihui Tuo Yan Zheng Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
[Retracted] Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB ‑152 < em > in vivo < /em > and < em > in vitro < /em > by inhibiting the PI3K/AKT/mTOR signaling pathway
Oncol Rep. 2024 May;51(5):66. doi: 10.3892/or.2024.8725. Epub 2024 Mar 15.ABSTRACTFollowing the publication of the above article, a concerned reader drew to the Editor's attention that the Transwell cell invasion assay data featured in Figs. 2D and 4E, certain of the tumor images in Fig. 5A and the TUNEL assay data in Fig. 5C were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Oncology Reports, or which under consideration for publication at around...
Source: Oncology Reports - March 15, 2024 Category: Cancer & Oncology Authors: Zhi Teng Shijuan Xu Qin Lei Source Type: research
