miR ‑425‑5p is associated with poor prognosis in patients with breast cancer and promotes cancer cell progression by targeting PTEN.
miR‑425‑5p is associated with poor prognosis in patients with breast cancer and promotes cancer cell progression by targeting PTEN. Oncol Rep. 2019 Oct 14;: Authors: Xiao S, Zhu H, Luo J, Wu Z, Xie M Abstract Breast cancer (BC) is the most common invasive cancer in women, and it imposes a heavy burden on patients. microRNAs (miRNAs/miRs) have been found to play an important role in the development of tumors, but their role in the malignant progression of BC is unclear. In the present study, the expression level of miR‑425‑5p was examined in patients with BC, and its association with prognosis w...
Source: Oncology Reports - October 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/ β‑catenin pathway.
The objective of the present study was to investigate the role of Tex10 in ESCC. For this purpose, the mRNA and protein expression of Tex10 was detected by reverse transcription‑quantitative PCR, western blot analysis and immunohistochemistry. In a loss‑of‑function experiment, EC109 cells were transfected with lentiviral vectors containing Tex10 short hairpin RNA or negative control. Cell proliferation was assessed using a Cell Counting kit‑8, and flow cytometry was used to analyze apoptosis and the cell cycle. Transwell assays were employed to examine the migratory and invasive capacity, and a sphere formation as...
Source: Oncology Reports - October 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Targeting RAD51 enhances chemosensitivity of adult T ‑cell leukemia‑lymphoma cells by reducing DNA double‑strand break repair.
Targeting RAD51 enhances chemosensitivity of adult T‑cell leukemia‑lymphoma cells by reducing DNA double‑strand break repair. Oncol Rep. 2019 Oct 22;: Authors: Yang M, Tian X, Fan Z, Yu W, Li Z, Zhou J, Zhang W, Liang A Abstract RAD51, is a key homologous recombination protein that repairs DNA damage and maintains gene diversity and stability. Previous studies have demonstrated that the over‑expression of RAD51 is associated with chemotherapy resistance of tumor cells to chemotherapy, and enhanced activity of DNA damage repair (DDR) systems contributes to resistance of adult T‑cell leuke...
Source: Oncology Reports - October 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

BH3 profiling discriminates the anti ‑apoptotic status of 5‑fluorouracil‑resistant colon cancer cells.
BH3 profiling discriminates the anti‑apoptotic status of 5‑fluorouracil‑resistant colon cancer cells. Oncol Rep. 2019 Oct 15;: Authors: Ishikawa K, Kawano Y, Arihara Y, Kubo T, Takada K, Murase K, Miyanishi K, Kobune M, Kato J Abstract 5‑Fluorouracil (5‑FU) is a cytotoxic anticancer drug commonly used for patients with advanced colon cancer. This drug effectively reduces the size of tumors to a certain degree; however, cancer cells can gradually acquire resistance, resulting in disease progression. To identify the mechanism of 5‑FU resistance, we established three 5‑FU‑resistant colon c...
Source: Oncology Reports - October 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of MUTYH contributes to cisplatin ‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT.
In conclusion, the present data demonstrated that EMT activation mediated by MUTYH downregulation, by both enhancing Twist transcription and blocking its degradation, is one of the mechanisms for acquisition of CDDP resistance in ESCC. PMID: 31578574 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor ‑associated macrophages.
Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor‑associated macrophages. Oncol Rep. 2019 Oct 01;: Authors: An G, Wu F, Huang S, Feng L, Bai J, Gu S, Zhao X Abstract The recurrence and metastasis of breast cancer limit the effectiveness of clinical treatments, making them important issues for clinicians to address. Tumor‑associated macrophages (TAMs) contribute to regulating the immune system. C‑C motif chemokine ligand 5 (CCL5) is an inflammatory chemokine that promotes chemotaxis on cells involved in the immune/inflammatory response. Br...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CAR T cell therapy: A new era for cancer treatment (Review).
Authors: Mohanty R, Chowdhury CR, Arega S, Sen P, Ganguly P, Ganguly N Abstract Cancer has recently been identified as the leading cause of mortality worldwide. Several conventional treatments and cytotoxic immunotherapies have been developed and made available to the market. Considering the complex behavior of tumors and the involvement of numerous genetic and cellular factors involved in tumorigenesis and metastasis, there is a need to develop a promising immunotherapy that targets tumors at both the cellular and genetic levels. Chimeric antigen receptor (CAR) T cell therapy has emerged as a novel therapeuti...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Systematic profiling of a novel prognostic alternative splicing signature in hepatocellular carcinoma.
In conclusion, the present study provides a comprehensive portrait of global splicing alterations involved in the progression and HCC in addition to valuable prognostic factors for patients, which may represent as underappreciated hallmark and provide novel clues of therapeutic targets in HCC. PMID: 31578577 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The prednisolone phosphate ‑induced suppression of the angiogenic function of tumor‑associated macrophages enhances the antitumor effects of doxorubicin on B16.F10 murine melanoma cells in vitro.
The prednisolone phosphate‑induced suppression of the angiogenic function of tumor‑associated macrophages enhances the antitumor effects of doxorubicin on B16.F10 murine melanoma cells in vitro. Oncol Rep. 2019 Oct 01;: Authors: Licarete E, Rauca VF, Luput L, Patras L, Sesarman A, Banciu M Abstract Several lines of evidence have clearly demonstrated the role of the tumor microenvironment in favoring the drug resistance of melanoma cells, as well as the progression of this cancer type. Since our previous studies proved that the accumulation of prednisolone disodium phosphate (PLP) in melanoma t...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma.
In conclusion, the results of the present study suggest the possible involvement of CTGF in the migration‑promoting effect and chemoresistance of EOC, suggesting that it may be a target for overcoming the malignant properties of EOC. PMID: 31578579 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genetic interactions between ANLN and KDR are prognostic for breast cancer survival.
This study contributes to breast cancer prognosis and therapeutic design by providing genetic evidence of interactions between ANLN and KDR, and suggesting the prominent role of the immune response in driving the synergies between the cancer cell life/death and angiogenesis/metastasis transitions during carcinogenesis. PMID: 31578580 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel therapeutic anti ‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells.
A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells. Oncol Rep. 2019 Sep 26;: Authors: Dho SH, Cho EH, Lee JY, Lee SY, Jung SH, Kim LK, Lim JC Abstract In recent years, efforts to treat cancer by improving the immune function of patients have received a great deal of attention. As part of the immune system, complement is also under such evaluation. Among the many components of the complement system, complement decay accelerating factor (CD55 or DAF) is known to inhibit complement‑mediated cell lysis. However, little is known about t...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review).
Authors: Krasanakis T, Nikolouzakis TK, Sgantzos M, Mariolis-Sapsakos T, Souglakos J, Spandidos DA, Tsitsimpikou C, Tsatsakis A, Tsiaoussis J Abstract Colorectal cancer (CRC) is one of the four leading causes of cancer‑related mortality worldwide. Even though over the past few decades the global scientific community has made tremendous efforts to understand this entity, many questions remain to be raised on this issue and even more to be answered. Epidemiological findings have unveiled numerous environmental and genetic risk factors, each one contributing to a certain degree to the final account of new CRC cases....
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Acquisition of temozolomide resistance by the rat C6 glioma cell line increases cell migration and side population phenotype.
Authors: Xu Y, Yang X, Mei S, Sun Y, Li J Abstract Cancer stem cells are reportedly associated with drug resistance in glioma, but there are conflicting findings on the effects of cancer stem cells on drug resistance. The aim of the present study was to identify the underlying mechanisms of drug resistance in rat C6 glioma cells, through the use of Transwell invasion assays, flow cytometric and western blot analyses as well as immunohistochemical staining. The results revealed that acquisition of drug resistance by C6 cells enhanced migration ability in vivo and in vitro. Notably, drug resistance did not ...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High levels of Notch intracellular cleaved domain are associated with stemness and reduced bevacizumab efficacy in patients with advanced colon cancer.
Authors: Negri F, Bozzetti C, Pedrazzi G, Azzoni C, Bottarelli L, Squadrilli A, Lagrasta C, Tamagnini I, Bisagni A, Ragazzi M, Porzio R, Tomasello G, Mori D, Leonardi F, Gnetti L, Crafa P, Sala R, Cascinu S Abstract δ‑like ligand 4 (DLL4)‑Notch signaling is associated with tumor resistance to anti‑vascular endothelial growth factor (VEGF) therapy. Furthermore, Notch signaling is critical for the maintenance of colon cancer stem cells (CSCs), which are relevant in drug resistance and tumor angiogenesis. CD44 is a transmembrane glycoprotein and is considered a putative marker of CSCs. To assess ...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Apurinic endonuclease 1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin ‑mediated mitophagy.
In conclusion, APE1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin‑mediated mitophagy. PMID: 31578585 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Potential role for second ‑generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis.
Potential role for second‑generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis. Oncol Rep. 2019 Sep 27;: Authors: Ishikawa M, Iriyama N, Tokuhira M, Takaku T, Sato E, Sugimoto KJ, Nakazato T, Fujita H, Kimura Y, Fujioka I, Komatsu N, Asou N, Kizaki M, Hatta Y, Kawaguchi T Abstract Tyrosine kinase inhibitor (TKI) treatment is the standard of care for patients with chronic myeloid leukemia (CML). Even in the imatinib era, the presence of 'clonal chromosomal abnormalities...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Activation of the Toll ‑like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro.
Activation of the Toll‑like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro. Oncol Rep. 2019 Sep 27;: Authors: Chen Y, Huang Z, Chen X, Ye H Abstract Toll‑like receptor 2 (TLR2), is an important pattern recognition receptor which serves a role in chronic inflammation of the liver. However, the role of TLR2 in the progression of human hepatocellular carcinoma (HCC) remains unknown. The aim of the present study was to examine the effects of the activation of the TLR2 signaling pathway on biological functions, such as proliferation and apoptosis. TLR2 expression in HCC ti...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Palmitoylome profiling indicates that androgens regulate the palmitoylation of α‑tubulin in prostate cancer‑derived LNCaP cells and supernatants.
Palmitoylome profiling indicates that androgens regulate the palmitoylation of α‑tubulin in prostate cancer‑derived LNCaP cells and supernatants. Oncol Rep. 2019 Sep 24;: Authors: Li W, Zhang J, Zou L, Cui J, Su F, Jin J, Xiao F, Liu M, Zhao G Abstract Prostate cancer is closely associated with constitutive transactivation of the androgen receptor (AR) signaling pathway. After treatment with androgen‑deprivation therapy (ADT), the majority of patients develop castration‑resistant prostate cancer within months or years. In order to investigate potential novel therapeutic targets in additio...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Follistatin ‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway.
Follistatin‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway. Oncol Rep. 2019 Sep 24;: Authors: Peng X, Wang P, Li S, Jiang Y, Wu C Abstract Gastric cancer is an aggressive disease and a common cause of cancer‑associated mortality worldwide. Recent studies have indicated that follistatin‑like protein 1 (FSTL‑1) is expressed and serves essential roles in tumorigenesis; however, the specific functional mechanism of FSTL‑1 in gastric cancer progression remains ambiguous. CellTiter‑Glo Luminescent Cell Viability and lactate dehydrogenase ...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ku80 gene knockdown by the CRISPR/Cas9 technique affects the biological functions of human thyroid carcinoma cells.
Authors: Fan Y, Li J, Wei W, Fang H, Duan Y, Li N, Zhang Y, Yu J, Wang J Abstract In the present study, to evaluate the role of Ku80 in thyroid carcinoma (TC), 86 thyroid tissue samples from patients with a spectrum of thyroid disorders were examined for protein levels of Ku80, nuclear factor‑κB (NF‑κB) and RET/TC by immunohistochemistry. Furthermore, in TC cells, Ku80 mRNA was detected by reverse transcription‑quantitative PCR analysis and silenced using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‑associated protein 9 (Cas9) technique to assess its role. An ant...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DDR1 promotes breast tumor growth by suppressing antitumor immunity.
Authors: Zhong X, Zhang W, Sun T Abstract Breast cancer is the second leading cause of cancer‑associated mortality among women worldwide. Triple‑negative breast cancer (TNBC) accounts for 15‑20% of all breast cancers and is defined by its aggressive nature and limited treatment options. Therefore, there is an urgent need to develop effective therapies for TNBC in order to improve breast cancer outcomes, as targeted therapies have done in other subtypes of breast cancer. Discoidin domain receptor tyrosine kinase 1 (DDR1) is activated by collagens, which are important components of the tumor stroma; t...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cytotoxicity of Cichorium intybus L. metabolites (Review).
Authors: Imam KMSU, Xie Y, Liu Y, Wang F, Xin F Abstract Cichorium intybus L. (Chicory) is a widely distributed, edible, perennial, herbaceous member of the Asteraceae family. Besides its use in modern Chinese herbal medicine, its ethnomedicinal use is evident in the text from ancient Greece, Egypt and China. It is also used as a food and coffee substitute, which is mainly responsible for its extensive domestication. In recent decades, cytotoxic studies of C. intybus extracts have shown its antitumor potential. These studies also identified metabolite constituents including guaianolides, 6‑methoxyflavone, eudesma...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

p53 deficiency augments nucleolar instability after ionizing irradiation.
Authors: Kakoti S, Yamauchi M, Gu W, Kato R, Yasuhara T, Hagiwara Y, Laskar S, Oike T, Sato H, Held KD, Nakano T, Shibata A Abstract Ribosomes are important cellular components that maintain cellular homeostasis through overall protein synthesis. The nucleolus is a prominent subnuclear structure that contains ribosomal DNA (rDNA) encoding ribosomal RNA (rRNA), an essential component of ribosomes. Despite the significant role of the rDNA‑rRNA‑ribosome axis in cellular homeostasis, the stability of rDNA in the context of the DNA damage response has not been fully investigated. In the present study, the number and...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma.
In conclusion, the present study revealed that upregulation of HHLA2 is significantly associated with a favorable outcome for patients with glioma. Targeting HHLA2 as an immune stimulator may become a valuable approach for the treatment of glioma in clinical practice. PMID: 31578594 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High blood levels of soluble OX40 (CD134), an immune costimulatory molecule, indicate reduced survival in patients with advanced colorectal cancer.
Authors: Sawada R, Arai Y, Sagawa Y, Nagata Y, Nishimura T, Noguchi M, Amano K, Arihiro S, Saruta M, Homma S Abstract The interaction between tumor necrosis factor receptor superfamily, member 4 (OX40) on T cells and the OX40 ligand (OX40L) on antigen‑presenting cells (APCs) is a pivotal step for T‑cell activation and the promotion of antitumor immunity. However, it is hypothesized that soluble OX40 (sOX40) in blood suppresses T‑cell activation by blocking the OX40/OX40L interaction. In the present study, the association between blood sOX40 levels and the clinical characteristics of advanced colorectal cancer...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Synchronous co ‑expression of Id‑1 and nuclear NF‑κB p65 promotes cervical cancer progression and malignancy, and is associated with a poor prognosis and chemosensitivity.
This study aimed to investigate the clinical significance of Id‑1 and NF‑κB p65 in cervical cancer and to elucidate their roles in malignant properties. Paraffin‑embedded cervical tissue specimens (n=85) were collected for immunohistochemistry and survival analysis. Targeting Id‑1 with lentivirus in vitro allowed the examination of the NF‑κB signaling pathway and cell survival. The results demonstrated the elevated co‑expression of Id‑1 and nuclear NF‑κB p65 was more frequently associated with aggressive cervical cancer behavior and poorer clinical outcomes. Targeting Id‑1 with shor...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Increased UCP1 expression in the perirenal adipose tissue of patients with renal cell carcinoma.
In conclusion, high UCP1 expression in the PAT may serve as an indicator of poor prognosis in RCC. PMID: 31545449 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma.
In conclusion, the methylation status of the SARDH‑CGI was identified as an independent prognostic candidate marker for RCC. PMID: 31545450 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gene expression and prognosis of insulin ‑like growth factor‑binding protein family members in non‑small cell lung cancer.
Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. Oncol Rep. 2019 Sep 16;: Authors: Wang J, Hu ZG, Li D, Xu JX, Zeng ZG Abstract Lung cancer is the leading cause of cancer mortality worldwide. Approximately 85% of all lung cancer cases are classified as non‑small cell lung cancer (NSCLC). Currently, there is no standard method to predict the survival of patients with NSCLC. Insulin‑like growth factor‑binding proteins (IGFBPs) function as modulators of IGF signaling and are attracting increasing attention for their role ...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Nicotinamide N ‑methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells.
Nicotinamide N‑methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells. Oncol Rep. 2019 Sep 16;: Authors: Hah YS, Cho HY, Jo SY, Park YS, Heo EP, Yoon TJ Abstract Cutaneous squamous cell carcinoma (cSCC) is a common malignancy initiated by keratinocytes of the epidermis, which are able to invade the dermis and its periphery. Although most patients with cSCC present with curable localized tumors, recurrence, metastasis and mortality occasionally occur. In the present study, nicotinamide N‑methyltransferase (NNMT) was identified as an upregulated protein in the SCC12...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miRNA ‑205‑5p functions as a tumor suppressor by negatively regulating VEGFA and PI3K/Akt/mTOR signaling in renal carcinoma cells.
miRNA‑205‑5p functions as a tumor suppressor by negatively regulating VEGFA and PI3K/Akt/mTOR signaling in renal carcinoma cells. Oncol Rep. 2019 Sep 10;: Authors: Huang J, Wang X, Wen G, Ren Y Abstract MicroRNAs (miRNAs) are involved in the development of various types of cancers. Dysregulation of miR‑205‑5p has been reported in various types of human cancer. However, little is known concerning the role of miR‑205‑5p in renal cell carcinoma (RCC). The pr~esent study was designed to investigate the role of miR‑205‑5p in RCC. The expression of miR‑205‑5p was measured in clear cell re...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulated IGFBP7 facilitates liver metastasis by modulating epithelial ‑mesenchymal transition in colon cancer.
In conclusion, the results of the present study suggested that IGFBP7 may prevent colon cancer metastasis by inhibiting EMT, and serves as a potential diagnostic marker and therapeutic target for patients with colon cancer. PMID: 31545454 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PI3K p110 α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673.
PI3K p110α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673. Oncol Rep. 2019 Sep 13;: Authors: Cao P, Wang Y, Lv Y, Jiang N, Zhong L, Ma X, Xiao X, Ding D, Gu J, Lin L, Li S Abstract Poly(ADP‑ribose) polymerase (PARP) inhibitors have little effect on homologous recombination repair (HRR)‑proficient tumor types, such as cervical cancer. In addition to catalytic activity, the PARP inhibitor, BMN673, traps PARP1 on damaged DNA and induces cytotoxic effects. The aim of the present study was to evaluate the therapeutic effect of PI3K inhi...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Serum proteomic analysis of melanoma patients with immunohistochemical profiling of primary melanomas and cultured cells: Pilot study.
Authors: Kučera J, Strnadová K, Dvořánková B, Lacina L, Krajsová I, Štork J, Kovářová H, Skalníková HK, Vodička P, Motlík J, Dundr P, Smetana K, Kodet O Abstract The steadily increasing incidence of malignant melanoma (MM) and its aggressive behaviour makes this tumour an attractive cancer research topic. The tumour microenvironment is being increasingly recognised as a key factor in cancer biology, with an impact on proliferation, invasion, angiogenesis and metastatic spread, as well as acquired therapy resistance. Multiple bioactive molecul...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA ‑942.
LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA‑942. Oncol Rep. 2019 Sep 12;: Authors: Chen Y, He J, Su C, Wang H, Chen Y, Guo W, Li Y, Ding G Abstract The present study aimed to investigate the potential mechanisms of human miR‑942 in the sunitinib‑resistance of renal cell carcinoma (RCC). A sunitinib‑resistant OS‑RC‑2 cell line was established by continuous exposure to increasing concentrations of sunitinib for ~12 weeks. The expression levels of four miRNAs were determined by reverse transcription‑quantitati...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Metastatic renal cell carcinoma cells growing in 3D on poly ‑D‑lysine or laminin present a stem‑like phenotype and drug resistance.
Metastatic renal cell carcinoma cells growing in 3D on poly‑D‑lysine or laminin present a stem‑like phenotype and drug resistance. Oncol Rep. 2019 Sep 18;: Authors: Brodaczewska KK, Bielecka ZF, Maliszewska-Olejniczak K, Szczylik C, Porta C, Bartnik E, Czarnecka AM Abstract 3D spheroids are built by heterogeneous cell types in different proliferative and metabolic states and are enriched in cancer stem cells. The main aim of the study was to investigate the usefulness of a novel metastatic renal cell carcinoma (RCC) 3D spheroid culture for in vitro cancer stem cell physiology research and dr...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑203a‑3p is a candidate tumor suppressor that targets thrombospondin 2 in colorectal carcinoma.
MicroRNA‑203a‑3p is a candidate tumor suppressor that targets thrombospondin 2 in colorectal carcinoma. Oncol Rep. 2019 Sep 12;: Authors: Qian Z, Gong L, Mou Y, Han Y, Zheng S Abstract The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2017. Total RNA extraction and reverse transcription‑quantitative po...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel deep learning architecture outperforming 'off ‑the‑shelf' transfer learning and feature‑based methods in the automated assessment of mammographic breast density.
In this study, we propose and evaluate advanced machine learning methodologies aiming at an objective and reliable method for breast density scoring from routine mammographic images. The proposed image analysis pipeline incorporates texture [Gabor filters and local binary pattern (LBP)] and gradient‑based features [histogram of oriented gradients (HOG) as well as speeded‑up robust features (SURF)]. Additionally, transfer learning approaches with ImageNet trained weights were also used for comparison, as well as a convolutional neural network (CNN). The proposed CNN model was fully trained on two open mammography datase...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Lung carcinoma therapy using epidermal growth factor receptor ‑targeted lipid polymeric nanoparticles co‑loaded with cisplatin and doxorubicin.
Lung carcinoma therapy using epidermal growth factor receptor‑targeted lipid polymeric nanoparticles co‑loaded with cisplatin and doxorubicin. Oncol Rep. 2019 Sep 18;: Authors: Nan Y Abstract The rate of lung cancer in tuberculosis (TB) patients is 7 to 30% higher than that in healthy individuals. Conventional chemotherapy of lung cancer shows limited efficiency due to poor tumor tissue drug accumulation and nonspecific cytotoxicity. Epidermal growth factor receptor (EGFR) is a promising target, which is overexpressed in lung carcinomas. In the present study, EGFR‑targeted nanopart...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

O ‑GlcNAc modification influences endometrial receptivity by promoting endometrial cell proliferation, migration and invasion.
O‑GlcNAc modification influences endometrial receptivity by promoting endometrial cell proliferation, migration and invasion. Oncol Rep. 2019 Sep 16;: Authors: Han X, Li X, Liu H, Zhang H, Li A, Dong M, Xu Y, Yan B, Sui L, Kong Y Abstract O‑linked β‑N‑acetylglucosamine (O‑GlcNAc) modification is a dynamic post‑translational modification process that is involved in many crucial biological processes, including cell cycle regulation, nutrient metabolism and extracellular signaling. This dynamic modification is dependent on the ambient glucose concentration and is catalyzed and removed by ...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PTEN/AKT signaling mediates chemoresistance in refractory acute myeloid leukemia through enhanced glycolysis.
Authors: Ryu MJ, Han J, Kim SJ, Lee MJ, Ju X, Lee YL, Son JH, Cui J, Jang Y, Chung W, Song IC, Kweon GR, Heo JY Abstract Primary refractory acute myeloid leukemia (AML) and early recurrence of leukemic cells are among the most difficult hurdles to overcome in the treatment of AML. Moreover, uncertainties surrounding the molecular mechanism underlying refractory AML pose a challenge when it comes to developing novel therapeutic drugs. However, accumulating evidence suggests a contribution of phosphatase and tensin homolog (PTEN)/protein kinase B (AKT) signaling to the development of refractory AML. To assess PTEN/AK...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑4712‑5p promotes proliferation of the vulvar squamous cell carcinoma cell line A431 by targeting PTEN through the AKT/cyclin D1 signaling pathways.
MicroRNA‑4712‑5p promotes proliferation of the vulvar squamous cell carcinoma cell line A431 by targeting PTEN through the AKT/cyclin D1 signaling pathways. Oncol Rep. 2019 Sep 17;: Authors: Yang S, Zhao Y, Wang L, Liu C, Lu Y, Fang Z, Shi H, Zhang W, Wu X Abstract The aim of the present study was to screen differentially expressed miRNAs in vulvar squamous cell carcinoma (VSCC), observe the role of microRNA‑4712‑5p in VSCC and investigate its targets and regulatory mechanism. Differentially expressed miRNAs in human VSCC tissues were screened. microRNA‑4712‑5p was selected and its expressi...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma.
Authors: Li H, Long J, Xie F, Kang K, Shi Y, Xu W, Wu X, Lin J, Xu H, Du S, Xu Y, Zhao H, Zheng Y, Gu J Abstract Cholangiocarcinoma (CCA) is acknowledged as the second most commonly diagnosed primary liver tumor and is associated with a poor patient prognosis. The present study aimed to explore the biological functions, signaling pathways and potential prognostic biomarkers involved in CCA through transcriptomic analysis. Based on the transcriptomic dataset of CCA from The Cancer Genome Atlas (TCGA), differentially expressed protein‑coding genes (DEGs) were identified. Biological function enrichment ana...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Clinical significance and biological role of KLF17 as a tumour suppressor in colorectal cancer.
Authors: Jiang X, Shen TY, Lu H, Shi C, Liu Z, Qin H, Wang F Abstract It has been reported that kruppel‑like factor 17 (KLF17) acts as a tumour suppressor in several tissues and cancer cells, however, the molecular roles, the underlying mechanisms and clinical significance of KLF17 in colorectal cancer (CRC) have not been completely elucidated. In the present study, KLF17 protein expression was detected in 140 primary CRCs and paired adjacent non‑tumour tissues using immunohistochemistry with tissue microarrays. The KLF17 mRNA expression was determined in 4 CRC cell lines and 20 pairs of the afor...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The four ‑microRNA signature identified by bioinformatics analysis predicts the prognosis of nasopharyngeal carcinoma patients.
The four‑microRNA signature identified by bioinformatics analysis predicts the prognosis of nasopharyngeal carcinoma patients. Oncol Rep. 2019 Sep 16;: Authors: Zhang S, Yue W, Xie Y, Liu L, Li S, Dang W, Xin S, Yang L, Zhai X, Cao P, Lu J Abstract The aim of the present study was to identify microRNAs (miRNAs) that predict the prognosis of patients with nasopharyngeal carcinoma by integrated bioinformatics analysis. First, the original microarray dataset GSE32960, including 312 nasopharyngeal carcinomas and 18 normal samples, was downloaded from the Gene Expression Omnibus database. In add...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The oncogenic role of NKAP in the growth and invasion of colon cancer cells.
Authors: Shu W, Liu G, Dai Y, Feng A, Chen Z, Han J, Li X Abstract It has been reported that NF‑κB activating protein (NKAP) is a transcriptional repressor of the Notch signaling pathway and is involved in the proliferation and survival of hematopoietic stem cells. In the present study, we aimed to investigate the effect of NKAP on the progression and metastasis of colon cancer. The results of immunohistochemical staining and western blot analysis showed that NKAP was upregulated in colon cancer tissues, and its expression was associated with colon cancer stages. CCK‑8, colony formation, Transwell, and fl...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
Authors: Li Q, Xu A, Chu Y, Chen T, Li H, Yao L, Zhou P, Xu M Abstract Ras‑associated protein 1A (Rap1A) is a member of the Ras subfamily of small GTP‑binding proteins and is found to promote metastasis in several types of cancer. However, the functional role and molecular mechanism of action in Rap1A in esophageal squamous cell carcinoma (ESCC) is not fully understood. In the present study, Rap1A was found to be upregulated in ESCC tissues and its expression was correlated with cancer stage. Functional studies revealed that Rap1A could promote ESCC metastasis by stimulating cell migration and invasio...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA ‑u50535 promotes the progression of lung cancer by activating CCL20/ERK signaling.
lncRNA‑u50535 promotes the progression of lung cancer by activating CCL20/ERK signaling. Oncol Rep. 2019 Sep 05;: Authors: Wei W, Zhao X, Zhu J, Zhang L, Chen Y, Zhang B, Li Y, Wang M, Zhang Z, Wang C Abstract The ligand/receptor pair C‑C motif chemokine ligand 20 (CCL20)/C‑C motif chemokine receptor 6 (CCR6) is considered to be highly activated in lung cancer and significantly accelerates lung cancer progression through activation of ERK signaling. In addition, it has been shown that long non‑coding RNA‑u50535 (lncRNA‑u50535) upregulates CCL20 expression and facilitates cancer progression ...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑141 inhibits proliferation, migration and invasion in human hepatocellular carcinoma cells by directly downregulating TGFβR1.
miR‑141 inhibits proliferation, migration and invasion in human hepatocellular carcinoma cells by directly downregulating TGFβR1. Oncol Rep. 2019 Sep 18;: Authors: Zhao Y, Xu Z, Zhou J, Yang H Abstract MicroRNAs (miRNAs) have been demonstrated to have crucial roles in modulating various human cancers. The present study examined the involvement of miR‑141 in modulating the proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells. Notably, the results demonstrated that miR‑141 was significantly downregulated in primary liver tumor tissues from patients compared with ...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research