Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc ‑1 cancer stem‑like cells.
Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc‑1 cancer stem‑like cells. Oncol Rep. 2018 Dec 06;: Authors: Peng G, Tang Z, Xiang Y, Chen W Abstract Reactive oxygen species (ROS) have been widely accepted as critical molecules playing regulatory roles in various biological processes, including proliferation, differentiation and apoptotic/ferroptotic/necrotic cell death. Emerging evidence suggests that ROS may be involved in the induction of epithelial‑to‑mesenchymal transition (EMT), which has been reported to promote can...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genetic, epigenetic and transcriptional comparison of esophagus tumor ‑associated and adjacent normal myofibroblasts.
Genetic, epigenetic and transcriptional comparison of esophagus tumor‑associated and adjacent normal myofibroblasts. Oncol Rep. 2018 Dec 06;: Authors: Huliák I, Bodai L, Czepán M, Kovács D, Szabó A, Tiszlavicz L, Lázár G, Rakonczay Z, Hegyi P, Boros IM, Kiricsi M Abstract Myofibroblasts (MFs) are present in healthy tissues and are also key components of the tumor microenvironment. In the present study a comparative analysis of MFs obtained from various gastrointestinal tumor tissues and from tumor‑adjacent normal tissues of cancer patients was performed, wi...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma.
In conclusion, SCCA protein is overexpressed in PTC and may represent a predictive prognostic factor for PTC patients. Furthermore, activation of the Ras/SCCA pathway plays an important role in promoting tumor growth, invasion and metastasis in PTC. PMID: 30535496 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑223 promotes hepatocellular carcinoma cell resistance to sorafenib by targeting FBW7.
MicroRNA‑223 promotes hepatocellular carcinoma cell resistance to sorafenib by targeting FBW7. Oncol Rep. 2018 Dec 06;: Authors: Tang X, Yang W, Shu Z, Shen X, Zhang W, Cen C, Cao L, Zhang M, Zheng S, Yu J Abstract Hepatocellular carcinoma (HCC) is a globally prevalent malignancy associated with a poor patient prognosis. We investigated the relationship between microRNA‑223 (miR‑223) expression and the sensitivity of HCC cells to sorafenib treatment. miR‑223 expression was determined in HCC cell lines with differential sorafenib sensitivity using reverse transcription‑quantitative PCR. miR‑...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression levels and co ‑targets of miRNA‑126‑3p and miRNA‑126‑5p in lung adenocarcinoma tissues: Αn exploration with RT‑qPCR, microarray and bioinformatic analyses.
Expression levels and co‑targets of miRNA‑126‑3p and miRNA‑126‑5p in lung adenocarcinoma tissues: Αn exploration with RT‑qPCR, microarray and bioinformatic analyses. Oncol Rep. 2018 Dec 04;: Authors: Chen P, Gu YY, Ma FC, He RQ, Li ZY, Zhai GQ, Lin X, Hu XH, Pan LJ, Chen G Abstract Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer. Previous studies have found that many microRNAs (miRNAs), including miRNA‑126‑3p, may play a critical role in the development of LUAD. However, no study of LUAD has researched the synergistic effects and co‑targets of b...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑98/PTEN/AKT pathway inhibits cell proliferation and malignant progression of hypopharyngeal carcinoma by MTDH.
MicroRNA‑98/PTEN/AKT pathway inhibits cell proliferation and malignant progression of hypopharyngeal carcinoma by MTDH. Oncol Rep. 2018 Dec 06;: Authors: Wang Q, Tan L, Liu J, Zhao J, Zhou X, Yu T Abstract Laryngeal carcinoma is one of the most common tumors concerning otorhinolaryngology head and neck surgery, however, the pathogenesis of laryngeal carcinoma remains unclear. MicroRNAs (miRNAs) have been reported to play vital roles in the pathogenesis of laryngeal carcinoma Herein, the present study was designed to explore the function and mechanism of miRNA‑98 in hypopharyngeal carcinoma. In brie...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

AT ‑101 induces G1/G0 phase arrest via the β‑catenin/cyclin D1 signaling pathway in human esophageal cancer cells.
In this study, we demonstrated that AT‑101 reduced the cell viability of human esophageal cancer cells by inducing G1/G0 phase arrest and apoptosis. Apoptotic cell death occurred later than cell cycle arrest, as evidenced by an increase in the proportion of Annexin V‑positive cells and cleaved caspase‑3, ‑9 and PARP protein levels. AT‑101 markedly downregulated the protein levels of phospho‑retinoblastoma (Ser 780) and cyclin D1, whereas it elevated protein levels of p53 and p21Waf1/Cip1, contributing to the inhibition of cell cycle progression. Moreover, AT‑101 substantially reduced ...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HOXA5 inhibits the proliferation and induces the apoptosis of cervical cancer cells via regulation of protein kinase B and p27.
Authors: Wang Z, Yu C, Wang H Abstract Homeobox A5 (HOXA5) is a member of the homeobox gene (HOX) family, which plays an important role in the development of various malignant tumors. Here, we speculated that HOXA5 has an effect on cervical cancer development. In our study, we aimed to explore the role and molecular mechanism of HOXA5 in regards to the cell proliferation and apoptosis in cervical cancer. We found that expression levels of HOXA5 measured by RT‑qPCR and western blot assays in cervical cancer cell lines and tissues were both significantly downregulated. We performed a gain‑of‑function experiment...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SETDB1 induces epithelial ‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter.
SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter. Oncol Rep. 2018 Nov 19;: Authors: Yang W, Su Y, Hou C, Chen L, Zhou D, Ren K, Zhou Z, Zhang R, Liu X Abstract SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 methyltransferase that is highly expressed in various tumor types, including breast cancer. However, how SETDB1 functions in breast cancer is unclear. In the present study, proliferation, migration and invasion assays were performed to explore the role of SETDB1 in breast cancer cells. SETDB1 downregulation in BT...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes.
Authors: Krazinski BE, Kowalczyk AE, Sliwinska-Jewsiewicka A, Grzegrzolka J, Godlewski J, Kwiatkowski P, Dziegiel P, Kmiec Z, Kiewisz J Abstract Inhibitor of nuclear factor kappa B kinase subunit B (IKBKB or IKKβ) is a key activator of the nuclear factor κB transcription factor pathway. Increased expression and/or aberrant activity of IKBKB have been observed in various types of human cancer. Three independent techniques, reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry, were used to demonstrate that IKBKB expression is decreased in clear...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Dual blockade of EGFR tyrosine kinase using osimertinib and afatinib eradicates EGFR ‑mutant Ba/F3 cells.
In conclusion, an initial treatment with a combination of osimertinib and afatinib is potentially more effective for eradicating mutant EGFR‑dependent cells than sequential drug use. This should be tested in future clinical trials to establish whether such a combination would be effective for the treatment of NSCLC. PMID: 30483795 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Lysine demethylase  2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition.
Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition. Oncol Rep. 2018 Nov 27;: Authors: Lu DH, Yang J, Gao LK, Min J, Tang JM, Hu M, Li Y, Li ST, Chen J, Hong L Abstract Metastasis is the most common cause of death in ovarian cancer patients but remains largely untreated. Epithelial‑mesenchymal transition (EMT) is critical for the conversion of early‑stage ovarian tumors into metastatic malignancies. Thus, investigating the signaling pathways promoting EMT may identify potential targets for the treatme...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Carvedilol suppresses malignant proliferation of mammary epithelial cells through inhibition of the ROS ‑mediated PI3K/AKT signaling pathway.
Carvedilol suppresses malignant proliferation of mammary epithelial cells through inhibition of the ROS‑mediated PI3K/AKT signaling pathway. Oncol Rep. 2018 Nov 19;: Authors: Ma Z, Liu X, Zhang Q, Yu Z, Gao D Abstract Reactive oxygen species (ROS) cause oncogenic mutations through direct interaction with DNA. Carvedilol (CAR) exhibits antioxidative activity, and pre‑clinical studies have identified that CAR may prevent malignant transformation in certain carcinogenic models. This suggests that CAR may be a potential agent in cancer prevention. In the present study, non‑cancerous MCF‑10A cells w...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor p16INK4 gene expression and prognosis in colorectal cancer.
Authors: Kitamura H, Takemura H, Minamoto T Abstract Hypermethylation of the tumor suppressor gene p16INK4 (p16) promoter is associated with worse prognosis in colorectal cancer (CRC). In the present study, it was investigated whether p16 mRNA expression correlates with the methylation of its promoter, and whether it influences prognosis in patients with CRC. DNA and RNA were extracted from 101 resected tumor specimens. A MethyLight assay was used to quantify p16 methylation in terms of percentage of methylated reference (PMR), and the expression of p16 mRNA was measured using reverse transcription‑polymerase cha...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to cisplatin in cervical cancer cells.
Authors: Vázquez-Mellado MJ, Cortés-Ballinas LG, Blanco-Flores IC, Aguilar C, Vázquez-Gómez G, Rocha-Zavaleta L Abstract Erythropoietin (Epo) is used for the treatment of cancer‑associated anaemia. However, certain studies have identified that the administration of Epo mediates the acquisition of resistance to cisplatin, which is widely used to treat cervical cancer. Our group previously reported that cervical cancer cells express Epo receptor and that exogenous Epo induces cell proliferation and migration. However, the effect of Epo on cervical cancer cell death mediated by chemothera...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells.
In conclusion, the present study provided novel information regarding the regulation of intratumoral androgen production in PCa, which is relevant for the progression of the disease to a castration‑resistant form. PMID: 30483800 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma.
Authors: Xue W, Ma L, Wang Z, Zhang W, Zhang X Abstract Forkhead box N3 (FOXN3) has been reported to be downregulated in numerous cancers, including laryngeal, oral squamous cell and hepatocellular carcinomas, and diffuse large B‑cell lymphoma. FOXN3 was proposed to serve as a tumor suppressor; however, the function of FOXN3 in osteosarcoma (OS) remains unknown. The present study suggested that FOXN3 was notably downregulated in OS tissues compared with in adjacent normal tissues, and the expression of FOXN3 was negatively correlated with tumor size, metastasis and tumor, node and metastasis stage. Additionally, ...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of long non ‑coding RNA expression patterns useful for molecular‑based classification of type I endometrial cancers.
Identification of long non‑coding RNA expression patterns useful for molecular‑based classification of type I endometrial cancers. Oncol Rep. 2018 Nov 21;: Authors: Ravo M, Cordella A, Saggese P, Rinaldi A, Castaldi MA, Nassa G, Giurato G, Zullo F, Weisz A, Tarallo R, Rizzo F, Guida M Abstract Endometrial cancer is the most frequently diagnosed gynecologic malignant disease. Although several genetic alterations have been associated with the increased risk of endometrial cancer, to date, the diagnosis and prognosis still rely on morphological features of the tumor, such as histological type, gr...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Docetaxel promotes cell apoptosis and decreases SOX2 expression in CD133 ‑expressing hepatocellular carcinoma stem cells by suppressing the PI3K/AKT signaling pathway.
Docetaxel promotes cell apoptosis and decreases SOX2 expression in CD133‑expressing hepatocellular carcinoma stem cells by suppressing the PI3K/AKT signaling pathway. Oncol Rep. 2018 Nov 27;: Authors: Zhang X, Shao J, Li X, Cui L, Tan Z Abstract Docetaxel is a front‑line standard‑of‑care chemotherapeutic drug for the treatment of cancers. However, the underlying function and mechanism of docetaxel in human hepatocellular carcinoma (HCC) are uncertain. Therefore, the present study aimed to determine the effects of docetaxel on cell apoptosis and SOX2 expression in cultured human HCC stem cells. ...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

BAI1 ‑associated protein 2‑like 2 is a potential biomarker in lung cancer.
BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer. Oncol Rep. 2018 Nov 26;: Authors: Xu L, Du H, Zhang Q, Wang C, Yan L, Tian G, Fu X Abstract Lung cancer is the leading cause of cancer‑related death worldwide. The underlying molecular mechanisms that trigger this disease remain largely unknown. The I‑BAR family is involved in regulating cell membrane formation and some members, such as BAIAP2L1, IRSp53 and MIM have been shown to participate in tumorigenic progression. However, the role of BAI1‑associated protein 2‑like 2 (BAIAP2L2) in cancer development is unclear. I...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of MUC1 predicts poor prognosis in patients with breast cancer.
Authors: Jing X, Liang H, Hao C, Yang X, Cui X Abstract Breast cancer is the most commonly diagnosed cancer in females; thus, there is an urgent requirement to identify precise biomarkers for the diagnosis and treatment of the disease. Mucin 1 (MUC1) is a glycoprotein that has been demonstrated to be involved in the metastasis and invasion of multiple tumor types. Bioinformatics analyses were conducted to indicate the prognostic value of MUC1 in breast cancer. Additionally, the expression level of MUC1 was assessed using Oncomine analysis. Furthermore, PrognoScan was used to analyze the prognostic value of MUC1 in ...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7.
In this study, we observed that miR‑154 expression was significantly downregulated in BCa tissues and cell lines, and was associated with several clinicopathological characteristics, including advanced T stage, lymphatic invasion, and distant metastasis. Low expression level of miR‑154 was associated with poor survival outcomes in BCa patients. Overexpression of miR‑154 led to significant decrease in the proliferation, migration, and invasion of BCa cells, while knockdown of miR‑154 yielded the opposite effect. ATG7 was identified as a direct target of miR‑154. ATG7 expression was negatively correlated with ...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

NADH dehydrogenase complex  I is overexpressed in incipient metastatic murine colon cancer cells.
NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells. Oncol Rep. 2018 Nov 27;: Authors: Marquez J, Kratchmarova I, Akimov V, Unda F, Ibarretxe G, Clerigué AS, Osinalde N, Badiola I Abstract Colon cancer is one of the most frequently occurring types of cancers in the world. Primary tumours are treated very efficiently, but the metastatic cases are known to have severe outcomes. Therefore, the aim of the present study was to obtain a greater understanding of the transformation of primary colon cancer cells into metastatic phenotypes. Small changes in...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration.
Authors: Mlynska A, Salciuniene G, Zilionyte K, Garberyte S, Strioga M, Intaite B, Barakauskiene A, Lazzari G, Dobrovolskiene N, Krasko JA, Pasukoniene V Abstract The management of advanced ovarian cancer is challenging due to the high frequency of recurrence, often associated with the development of resistance to platinum‑based chemotherapy. Molecular analyses revealed the complexity of ovarian cancer with particular emphasis on the immune system, which may contribute to disease progression and response to treatment. Cytokines and chemokines mediate the cross‑talk between cancer and immune cells, and therefore...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Involvement of the glutamine RF ‑amide peptide and its cognate receptor GPR103 in prostate cancer.
Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer. Oncol Rep. 2018 Nov 27;: Authors: Kawan MA, Kyrou I, Ramanjaneya M, Williams K, Jeyaneethi J, Randeva HS, Karteris E Abstract Glutamine RF‑amide peptide (QRFP) belongs to the RFamide neuropeptide family, which is involved in a wide spectrum of biological activities, ranging from food intake and cardiovascular functioning to analgesia, aldosterone secretion, locomotor activity and reproduction. Recently, QRFP has been demonstrated to exert its effects by activating the G protein‑coupled receptor GPR10...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Molecular mechanism of LKB1 in the invasion and metastasis of colorectal cancer.
Authors: Chen Y, Liu Y, Zhou Y, You H Abstract The occurrence of colorectal cancer (CRC) is associated with a variety of oncogenes and tumor‑suppressor genes. As a tumor‑suppressor gene, the liver kinase B1 gene (LKB1, also known as serine/threonine kinase 11, STK11) is closely related to tumor angiogenesis, invasion and metastasis, but its molecular mechanisms remain unclear. The aim of the present study was to investigate the effects of LKB1 on the invasion and metastasis of CRC, and to explore its molecular mechanisms. By detecting the expression of LKB1 in CRC, we can provide a reference index for diagnosin...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Levistolide  A synergistically enhances doxorubicin‑induced apoptosis of k562/dox cells by decreasing MDR1 expression through the ubiquitin pathway.
Levistolide A synergistically enhances doxorubicin‑induced apoptosis of k562/dox cells by decreasing MDR1 expression through the ubiquitin pathway. Oncol Rep. 2018 Nov 27;: Authors: Ding Y, Niu W, Zhang T, Wang J, Cao J, Chen H, Wang R, An H Abstract Multidrug resistance (MDR) is one of the main reasons underlying failure of cancer chemotherapy. Certain natural compounds may help prevent MDR, and may be used in combination with chemotherapeutic agents to enhance their efficacy. Levistolide A is a natural product that is extracted from the rhizome of Angelicae sinensis (Oliv.), which has been use...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Biological role of metabolic reprogramming of cancer cells during epithelial ‑mesenchymal transition (Review).
Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review). Oncol Rep. 2018 Nov 23;: Authors: Li M, Bu X, Cai B, Liang P, Li K, Qu X, Shen L Abstract Epithelial‑mesenchymal transition (EMT) is required for the distant metastasis of tumors. The degree of tumor malignancy increases as EMT progresses. Notably, the biology of tumor cells differs from that of normal cells, with regards to characteristics and energy metabolism mechanisms; abnormal glucose metabolism, excessive accumulation of fatty acids and other metabolic disorders occur in metastatic t...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Leukocyte ‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC.
Leukocyte‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC. Oncol Rep. 2018 Nov 20;: Authors: Jingushi K, Uemura M, Nakano K, Hayashi Y, Wang C, Ishizuya Y, Yamamoto Y, Hayashi T, Kinouchi T, Matsuzaki K, Kato T, Kawashima A, Ujike T, Nagahara A, Fujita K, Ueda K, Tsujikawa K, Nonomura N Abstract Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, responsible for approximately 90‑95% of cases. We previously reported a novel method that enables direct extraction of extracellular vesicles (EVs) from surgically resected viable tissues, yielding ...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of cell proliferation and migration in non ‑small cell lung cancer cells through the suppression of LYPLA1.
In this study, we provide the expression pattern of LYPLA1 in non‑small cell lung cancer (NSCLC) using four different NSCLC cell lines. Western blot analysis and RT‑PCR were performed to detect the protein expression and mRNA expression of LYPLA1 in NSCLC cell lines. We detected the highest LYPLA1 protein expression level in SPC‑A‑1 cells followed by A549 cells, and the highest LYPLA1 mRNA expression level was detected in the SPC‑A‑1 cells followed by the H1299 cell line. We found that suppression of LYPLA1 expression using small‑interfering RNA significantly inhibited proliferation, migration and invasion of...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA MALAT1 correlates with cell viability and mobility by targeting miR‑22‑3p in renal cell carcinoma via the PI3K/Akt pathway.
In conclusion, lncR‑MALAT1 affected the proliferation and migration of RCC cells by targeting miR‑22‑3p through the inactivation of the PI3K/Akt signaling pathway. PMID: 30431104 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miRNA ‑885‑3p inhibits docetaxel chemoresistance in lung adenocarcinoma by downregulating Aurora A.
miRNA‑885‑3p inhibits docetaxel chemoresistance in lung adenocarcinoma by downregulating Aurora A. Oncol Rep. 2018 Nov 09;: Authors: Cao J, Geng J, Chu X, Wang R, Huang G, Chen L Abstract Aurora A is a member of the mitotic serine/threonine kinase family. It is involved in key processes during mitosis and meiosis, and Aurora A upregulation is implicated in malignant transformation. In the present study, we revealed that Aurora A expression was significantly higher in docetaxel‑resistant lung adenocarcinoma (LAD) cells than in parental cells. Higher levels of Aurora A expr...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Mitochondrial ‑DNA‑associated TLR9 signalling is a potential serological biomarker for non‑small cell lung cancer.
Mitochondrial‑DNA‑associated TLR9 signalling is a potential serological biomarker for non‑small cell lung cancer. Oncol Rep. 2018 Nov 09;: Authors: Lai YH, Liu HY, Huang CY, Chau YP, Wu S Abstract Mitochondrial (mt) DNA has been long suggested to contribute to carcinogenesis, and a variety of mutations in mtDNA have been confirmed to be related to various early stages of cancers; these data revealed that the detection of mtDNA in clinical samples may be a promising approach for cancer diagnosis. In the present study, the serum mtDNA in healthy donors and groups of patients with cancer was detecte...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Glutathione S ‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer.
Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer. Oncol Rep. 2018 Nov 09;: Authors: Zou M, Hu X, Xu B, Tong T, Jing Y, Xi L, Zhou W, Lu J, Wang X, Yang X, Liao F Abstract The roles of glutathione S‑transferase pi 1 (GSTP1), glutathione S‑transferase mu 2 (GSTM2) and glutathione S‑transferase alpha 1 (GSTA1) in cisplatin (DDP)‑resistance of solid cancer cells (A549/DDP, SKOV3/DDP and SGC7901/DDP) were compared following expression downregulation with small interfering RNAs (siRNAs). DDP cytotoxicity was reflected by...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TROAP regulates prostate cancer progression via the WNT3/survivin signalling pathways.
Authors: Ye J, Chu C, Chen M, Shi Z, Gan S, Qu F, Pan X, Yang Q, Tian Y, Wang L, Yang W, Cui X Abstract Prostate cancer (PCa) is one of the most commonly diagnosed malignancies, and 90% of advanced prostate cancer patients relapse after therapy. Trophinin associated protein (TROAP) is essential for centrosome integrity and proper bipolar organisation of spindle assembly during mitosis and plays an essential role in proliferation. We found that TROAP expression correlates with patient survival and speculated that it may be involved in PCa progression. The Oncomine database tool (http://www.oncomine.org) was used to ...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Netrin ‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation.
[Corrigendum] Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation. Oncol Rep. 2018 Nov 09;: Authors: Yin K, Shang M, Dang S, Wang L, Xia Y, Cui L, Fan X, Qu J, Chen J, Xu Z Abstract During the preparation of the figures in the above article, the authors inadvertently selected images for the shCTL experiments portrayed in Fig. 5I and J (for the MGC803 and SGC7901 cell lines, respectively) that were generated from the same original data source. A corrected version of Fig. 5 is shown opposite, showing the correct data for t...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A.
Authors: Lu J, Lin JX, Zhang PY, Sun YQ, Li P, Xie JW, Wang JB, Chen QY, Cao LL, Lin Y, Huang CM, Zheng CH Abstract Several previous studies have demonstrated that cyclin‑dependent kinase (CDK)‑5 expression serves an important role in promoting the development of malignant tumours. We have previously reported that CDK5 suppresses gastric tumourigenesis. The aim of the present study was to investigate the mechanistic basis of CDK5. The results of immunoprecipitation and western blot analysis demonstrated that CDK5 could interact with serine/threonine‑protein phosphatase 2A (PP2A). The use of an inhibitor ...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TROP2 promotes the proliferation and metastasis of glioblastoma cells by activating the JAK2/STAT3 signaling pathway.
Authors: Hou J, Lv A, Deng Q, Zhang G, Hu X, Cui H Abstract Trophoblast cell surface antigen 2 (TROP2), a single transmembrane domain protein, is often found to be highly expressed in various types of human cancers. However, the biological function and molecular mechanism of TROP2 in glioblastoma have not been fully elucidated, particularly in regards to cell proliferation and metastasis of glioblastoma cells. In the present study, it was demonstrated that TROP2 expression was increased in glioblastoma tissues and glioblastoma cell lines by immunohistochemical analysis and western blot analysis. High TROP2 exp...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Evironmental pollutant perfluorodecanoic acid upregulates cIAP2 to suppress gastric cell senescence.
Authors: Zhang Z, Song N, Peng Y, Fan Z, Han M, Zhao M, Dong T, Liu S Abstract The role of perfluorodecanoic acid (PFDA) in gastric carcinogenesis and its mechanism remains unknown. Our previous research revealed that PFDA regulated the growth of human gastric cells. However, its core molecules and basic mechanisms are still not clear. In the present study, cDNA microarrays were used to determine mRNA changes in AGS cells after treatment with PFDA. DAVID analysis of the genes with >2‑fold increased expression in microarray data revealed five genes which were involved in cancer pathways. The most upregulat...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor suppressor PLZF regulated by lncRNA ANRIL suppresses proliferation and epithelial mesenchymal transformation of gastric cancer cells.
Authors: Wang JB, Jin Y, Wu P, Liu Y, Zhao WJ, Chen JF, De W, Yang F Abstract Promyelocytic leukemia zinc finger (PLZF) plays important roles in tumorigenic and developmental processes of various types of cancers. However, the expression of PLZF in gastric cancer (GC) has not been reported. The aim of the present study was to investigate the expression level and potential status of PLZF in GC as well as its possible mechanism. In the present study, we found that PLZF was downregulated in the majority of GC cell lines and tumor tissues and that alteration of PLZF expression was closely correlated with a malignant ph...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Functional analysis of protein disulfide isomerase  P5 in glioblastoma cells as a novel anticancer target.
Functional analysis of protein disulfide isomerase P5 in glioblastoma cells as a novel anticancer target. Oncol Rep. 2018 Nov 15;: Authors: Horibe T, Torisawa A, Masuda Y, Kawakami K Abstract P5, which is a member of the protein disulfide isomerase family, possesses isomerase and chaperone activity in vitro; however, the physiological functions of this enzyme in cells remain unclear. To understand the important roles of P5 in cancer cells, the present study examined its expression on the surface of normal and cancer cell lines by flow cytometry using an affinity‑purified anti‑P5 antibody ...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Pathway analysis of a genome ‑wide association study on a long non‑coding RNA expression profile in oral squamous cell carcinoma.
Pathway analysis of a genome‑wide association study on a long non‑coding RNA expression profile in oral squamous cell carcinoma. Oncol Rep. 2018 Nov 15;: Authors: Qiu YL, Liu YH, Ban JD, Wang WJ, Han M, Kong P, Li BH Abstract Long non‑coding RNAs (lncRNAs) have been consistently demonstrated to be involved in oral squamous cell carcinoma (OSCC) as either tumor oncogenes or tumor suppressors. However, the underlying mechanisms of OSCC tumorigenesis and development have not yet been fully elucidated. The expression profiles of mRNAs and lncRNAs in OSCC were analyzed by a microarray assay. To verify...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Comparative proteomic analysis identifies exosomal Eps8 protein as a potential metastatic biomarker for pancreatic cancer.
Authors: Ohshima K, Hatakeyama K, Kanto K, Ide T, Watanabe Y, Moromizato S, Wakabayashi-Nakao K, Sakura N, Yamaguchi K, Mochizuki T Abstract Exosomes are small vesicles found in extracellular environments including blood, urine, and cell culture medium. Their contents are cell‑type specific, and molecules embedded in exosomes can be useful fluid‑based clinical biomarkers. To identify proteins with metastatic marker potential, we conducted a comparative exosomal proteome analysis using human pancreatic cancer cell lines derived from metastasis, ascites, and primary tumors. Metastatic potential of cell lines was ...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Epigenetic knockdown of Notch1 inhibits hepatitis B virus X protein ‑induced hepatocarcinogenesis of L02/HBx cells.
Epigenetic knockdown of Notch1 inhibits hepatitis B virus X protein‑induced hepatocarcinogenesis of L02/HBx cells. Oncol Rep. 2018 Nov 15;: Authors: Peng Y, Zhou D, Ye Y, Kai C, Jiang Z, Zhu Z, Wu X, Xiong J Abstract The present study aimed to investigate the effects of Notch1 on the development of hepatitis B virus X protein (HBx)‑induced hepatocarcinogenesis. The L02/HBx cells were transfected with a short hairpin RNA (shRNA) specially targeting Notch1 (Notch1‑shRNA). The mRNA and protein expression levels of Notch1 signaling pathway‑related molecules (Notch1, Hes1 and NICD) were detected aft...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells.
Authors: Yanagawa-Matsuda A, Mikawa Y, Habiba U, Kitamura T, Yasuda M, Towfik-Alam M, Kitagawa Y, Minowa K, Shindoh M, Higashino F Abstract AU-rich elements (AREs) are RNA elements that enhance the rapid decay of mRNA. The fate of ARE-mRNA is controlled by ARE-binding proteins. HuR, a member of the embryonic lethal abnormal vision (ELAV) family of RNA-binding proteins, is involved in the export and stabilization of ARE-mRNA. In the vast majority of cancer cells, HuR constitutively relocates to the cytoplasm, resulting in the stabilization of ARE-mRNA. Previously, we described that the adenovirus gene product, E4orf...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Exosomes derived from PM2.5 ‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway.
Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway. Oncol Rep. 2018 Nov 09;: Authors: Xu H, Jiao X, Wu Y, Li S, Cao L, Dong L Abstract Fine particulate matter (PM2.5) is associated with an increased lung cancer risk. However, the effect of PM2.5 exposure on lung cancer cells is still largely unknown. The present study revealed that A549 lung cancer cells secreted exosomes containing high levels of Wnt3a after treatment with PM2.5. These exosomes activated β‑catenin signalling in A549 cells. These exosomes exhibited no ...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells.
Authors: Chen X, Song L, Hou Y, Li F Abstract Increased production of reactive oxygen species (ROS) is a distinct feature of various types of cancer. ROS drive tumor progression and render cancer cells vulnerable to additional oxidative insult. The various natural herb compounds have been shown to induce additional production of ROS in cancer cells, although the physiological implications of ROS under these conditions are not fully determined. In the present study, icaritin, a natural compound derived from the medicinal plants Epimedium, was demonstrated to potently suppresses the proliferation of human HeLa and Si...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ERK5 ‑regulated RERG expression promotes cancer progression in prostatic carcinoma.
ERK5‑regulated RERG expression promotes cancer progression in prostatic carcinoma. Oncol Rep. 2018 Nov 05;: Authors: Xiong Y, Huang H, Chen S, Dai H, Zhang L Abstract Big mitogen‑activated protein kinase 1 [also named extracellular signal‑regulated kinase (ERK) 5] is activated by mitogens and oncogenic signals and is strongly implicated in tumorigenesis. Our previous investigation indicated that ERK5 can induce prostatic carcinoma cell proliferation by promoting entry into the S phase of the cell cycle. In the present study, microarray and western blot analysis revealed that ERK5 can inhibit...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKT inhibitor  MK2206 in mammary cancer models.
[Corrigendum] Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKT inhibitor MK2206 in mammary cancer models. Oncol Rep. 2018 Oct 17;: Authors: Lubet RA, Steele VE, Juliana MM, Bode A, Moeinpour F, Grubbs CJ Abstract The AKT inhibitor employed in this article was identified as MK 2206 (8‑[4‑(1‑aminocyclobutyl) phenyl]‑9‑phenyl‑1,2,4‑ triazolo[3,4‑f][1,6]naphthyridin‑3(2H)‑one hydrochloride (1:2). However, another AKT inhibitor was actually used, which is typically identified as Akt I‑1,2 (HC,I. IPA (2‑[4‑(3‑phenylquinoxalin‑2‑yl)phenyl]...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑301a targets WNT1 to suppress cell proliferation and migration and enhance radiosensitivity in esophageal cancer cells.
MicroRNA‑301a targets WNT1 to suppress cell proliferation and migration and enhance radiosensitivity in esophageal cancer cells. Oncol Rep. 2018 Oct 16;: Authors: Su H, Wu Y, Fang Y, Shen L, Fei Z, Xie C, Chen M Abstract Esophageal cancer (EC) is one of the leading causes of death among malignancies. Radiotherapy for esophageal squamous cell carcinoma (ESCC) patients is limited by resistance to ionizing radiation (IR). An increasing body of evidence has demonstrated that aberrant expression of microRNA‑301a (miR‑301a) contributes to cancer progression and sensitivity to radiation. The aim of the ...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research