A novel regulatory circuit of miR ‑152 and DNMT1 in human bladder cancer.
A novel regulatory circuit of miR‑152 and DNMT1 in human bladder cancer. Oncol Rep. 2018 Jul 10;: Authors: Zhang H, Qi D, Li J, Peng T, Yang L, Yuan J, Zhang Y, Hu Y, Su J, Que B, Li M, Zhou G, Chen Y, Zhang W, Ji W Abstract Downregulation of microRNA‑152 (miR‑152) has been observed in various types of human malignancies, including Bladder cancer (BC). However, the role of miR‑152 in the development and progression of BC is still unclear. In our previous study, we identified a functional crosstalk between miR‑152 and DNA methyltransferase 1 (DNMT1) involved in Nis‑induced malignant tra...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Associations of miR ‑146aC > G, miR ‑149C > T, miR ‑196a2C > T and miR ‑499A > G polymorphisms with brain tumors.
In conclusion, these results suggested that the miR‑149 polymorphism may be involved in the development of gliomas, and the C‑C‑G haplotype of miR‑149T>C, miR‑196a2T>C and miR‑499A>G showed increased odds ratios for all types of brain tumors. PMID: 30015947 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

BMP9 inhibits the growth of breast cancer cells by downregulation of the PI3K/Akt signaling pathway.
Authors: Li S, Dai H, He Y, Peng S, Zhu T, Wu Y, Li C, Wang K Abstract Bone morphogenetic protein 9 (BMP9) is a member of the BMP family, which is involved in the regulation of tumor biogenesis, development and metastasis. The present study aimed to investigate whether BMP9 inhibits the growth of MDA‑MB‑231 breast cancer cells via the phosphoinositide 3‑kinase (PI3K)/Akt signaling pathway. It was shown that the expression level of BMP9 was significantly decreased, while that of phosphorylated Akt (p‑Akt) was markedly increased in breast cancer tissues compared with these levels in the normal adjac...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma ‑bearing mouse model.
Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma‑bearing mouse model. Oncol Rep. 2018 Jul 12;: Authors: Lin WC, Wang WH, Lin YH, Leu JD, Cheng SY, Chen YJ, Hwang JJ Abstract Tetrandrine (TET), a traditional Chinese clinical agent, has been used for the treatment of many diseases, including cancers. The purpose of the present study was to investigate the combined effects of TET and ionizing radiation (IR) on murine CT26 colorectal adenocarcinoma cells in vitro and in vivo. A CT26 cell line transfected with dual HSV‑1 thymidine kinase and ...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑448 targets Rab2B and is pivotal in the suppression of pancreatic cancer.
In this study, Rab2B is target of miR‑488 was confirmed by bioinformatics analysis and validated using a luciferase reporter assay. A total of 72 cases of pancreatic cancer in patients diagnosed at The First Affiliated Hospital, School of Medicine, Zhejiang University (Hangzhou, China) were enrolled, and cancer specimens and their adjacent normal tissues were collected for analysis. The expression levels of miR‑448 and Rab2B in these tissues and in pancreatic cancer cell lines were quantified using reverse transcription‑polymerase chain reaction analysis. miR‑448 overexpression was achieved by cell transfection. Pr...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Moxidectin inhibits glioma cell viability by inducing G0/G1  cell cycle arrest and apoptosis.
In conclusion, these results suggest that MOX may inhibit the viability of glioma cells by inducing cell apoptosis and cell cycle arrest, and may be able to function as a potent and promising agent in the treatment of glioma. PMID: 30015956 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Developing a radiosensitivity gene signature for Caucasian patients with breast cancer.
Authors: Ji Y, Jiang Q, Jian G, Sun H, Wang Y, Qin H, Zhang S, Cao J, Tang Z Abstract Adjuvant radiotherapy is an important clinical treatment option for patients with breast cancer. However, for Caucasian patients, the clinical benefit of adjuvant radiotherapy can differ from African‑American patients with respect to the overall survival. The goal of the current study was to develop a gene signature and to pre‑identify patients likely to benefit from radiotherapy. Using publicly available breast cancer data from The Cancer Genome Atlas, a new cross‑validation procedure was proposed for developing a gene sign...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of metadherin inhibits cell proliferation and migration in colorectal cancer.
Authors: Li JW, Huang CZ, Li JH, Yuan JH, Chen QH, Zhang WF, Xu ZS, Liu YP, Li Y, Zhan MX, Lu LG Abstract Metadherin (MTDH) is a multifunctional oncogene involved in tumor cell migration and metastasis through regulating a number of oncogenic signaling pathways in various human malignancies. Previous studies have demonstrated that MTDH is overexpressed in human colorectal cancer (CRC) and associated with cancer progression and a poor prognosis. However, the underlying mechanisms remain largely unknown. The present study investigated the expression and role of MTDH in CRC cells as well as the underlying mechanism of...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DMBA promotes ErbB2 ‑mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability.
DMBA promotes ErbB2‑mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability. Oncol Rep. 2018 Jul 04;: Authors: Ma Z, Kim YM, Howard EW, Feng X, Kosanke SD, Yang S, Jiang Y, Parris AB, Cao X, Li S, Yang X Abstract Environmental factors, including 7,12‑dimethylbenz[a]anthracene (DMBA) exposure, and genetic predisposition, including ErbB2 overexpression/amplification, have been demonstrated to increase breast cancer susceptibility. Although DMBA‑ and ErbB2‑mediated breast cancers are well‑studied in their respective models, key interactions between envi...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MET ‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients.
In conclusion, MET‑RON upregulation is a poor prognostic factor in CCA patients receiving hepatectomies and may be targeted using BMS‑77760. PMID: 30015968 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑495 enhances the efficacy of radiotherapy by targeting GRP78 to regulate EMT in nasopharyngeal carcinoma cells.
miR‑495 enhances the efficacy of radiotherapy by targeting GRP78 to regulate EMT in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Jul 02;: Authors: Feng X, Lv W, Wang S, He Q Abstract Glucose‑regulated protein 78 (GRP78) was revealed to be associated with the radioresistance of nasopharyngeal carcinoma (NPC) in our previous study. GRP78 is a highly expressed cell surface protein, and holds great promise as a cancer specific target. Its expression may be impacted by the regulation of miRNAs, which may be involved in the radioresistance of NPC. A better understanding of the mechanisms of radio...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Caveolin ‑1 enhances RANKL‑induced gastric cancer cell migration.
Caveolin‑1 enhances RANKL‑induced gastric cancer cell migration. Oncol Rep. 2018 Jul 05;: Authors: Wang Y, Song Y, Che X, Zhang L, Wang Q, Zhang X, Qu J, Li Z, Xu L, Zhang Y, Fan Y, Hou K, Liu Y, Qu X Abstract The classical pathway involving receptor activator of nuclear factor‑κB (RANK) and its ligand (RANKL) induces the activation of osteoclasts and the migration of a variety of tumor cells, including breast and lung cancer. In our previous study, the expression of RANK was identified on the surface of gastric cancer cells, however, whether the RANKL/RANK pathway is involved in the regula...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Suppression of the SDF ‑1/CXCR4/β‑catenin axis contributes to bladder cancer cell growth inhibition in vitro and in vivo.
In conclusion, targeting the SDF‑1/CXCR4/β‑catenin axis may be a potential therapeutic target for suppressing BCa progression. PMID: 30015971 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Combined assessment of low PGRMC1/positive ATP1A1 levels has enhanced prognostic value for renal cell carcinoma.
Authors: He Y, Zhang P, Zhang D, Xia Z, Wang X, Deng S, Li H, Zhu H, Xu N, Liang S Abstract Progesterone receptor membrane component 1 (PGRMC1) and Na+/K+‑ATPase α1 subunit (ATP1A1) are two proteins associated with the clinical prognosis of renal cell carcinoma (RCC) and RCC cell proliferation. However, the two proteins have been previously studied independently, and their combined influence on the clinical outcome of RCC remains unclear. The present study suggests that the combined expression levels of PGRMC1 and ATP1A1 (PGRMC1/ATP1A1) are associated with the clinical prognosis of RCC patients. R...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Structure activity relationships of chrysoeriol and analogs as dual c ‑Met and VEGFR2 tyrosine kinase inhibitors.
Structure activity relationships of chrysoeriol and analogs as dual c‑Met and VEGFR2 tyrosine kinase inhibitors. Oncol Rep. 2018 Jul 02;: Authors: Lai S, Chen JN, Huang HW, Zhang XY, Jiang HL, Li W, Wang PL, Wang J, Liu FN Abstract Vascular endothelial growth factor receptor 2 (VEGFR2) and c‑Met are tyrosine kinases, which are involved in the tumorigenesis of various types of cancer. Previous studies have demonstrated that the elevated activation of c‑Met is associated with the drug resistance of VEGFR2 inhibitors. Therefore, dual c‑Met and VEGFR2 kinase inhibitors are expected to overcome...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation ‑dependent apoptosis.
Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation‑dependent apoptosis. Oncol Rep. 2018 Jul 04;: Authors: Zeng C, Li X, Li A, Yi B, Peng X, Huang X, Chen J Abstract Nuclear protein‑1 (NUPR1) is a stress response factor that is important in the development of several human malignant tumor cells. However, the role of NUPR1 in multiple myeloma (MM) remains to be fully elucidated. In the present study, it was found that the mRNA levels of NUPR1 were significantly higher in specimens from patients with MM and MM cell lines (...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Casticin suppresses the carcinogenesis of small cell lung cancer H446 cells through activation of AMPK/FoxO3a signaling.
Authors: Gong Q, Cao X, Cao J, Yang X, Zeng W Abstract Casticin, a natural polymethoxyflavone isolated from A. annua, V. trifolia, and V. agnus‑castus induces apoptosis in cancer cells by activating FoxO3a. However, whether casticin inhibits in vitro carcinogenesis and cancer stem cell (CSC) characteristics, and whether casticin activates FoxO3a in small cell lung cancer (SCLC) cells remain unclear. We here demonstrated that casticin decreased sphere‑ and colony‑formation capabilities, and downregulated uPAR and CD133 in second‑generation spheres, which were considered as lung cancer ste...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Let ‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase 6.
Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase 6. Oncol Rep. 2018 Jul 13;: Authors: Song J, Wang L, Ma Q, Yang Y, Yang Z, Wang B, He N Abstract Colorectal cancer is one of the most common types of malignancies worldwide, and as it is often diagnosed at an advanced stage, it is a serious threat to human health. MicroRNAs are important regulators of the growth and metastasis of colon cancer (CC). In the present study, the results demonstrated that kallikrein‑related peptidase 6 (KLK6) plays a critical role in suppressi...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of miR ‑221 and miR‑222 in the cancer stroma is associated with malignant potential in colorectal cancer.
Overexpression of miR‑221 and miR‑222 in the cancer stroma is associated with malignant potential in colorectal cancer. Oncol Rep. 2018 Jul 13;: Authors: Iida M, Hazama S, Tsunedomi R, Tanaka H, Takenouchi H, Kanekiyo S, Tokumitsu Y, Tomochika S, Tokuhisa Y, Sakamoto K, Suzuki N, Takeda S, Ueno T, Yamamoto S, Yoshino S, Fujita K, Kuroda M, Nagano H Abstract The cancer stroma is important in cancer development, however, whether the aberrant expression of microRNAs (miRNAs) in the cancer stroma is associated with cancer progression remains to be fully elucidated. The aim of the present study was to i...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Pin2/TRF1 ‑binding protein X1 inhibits colorectal cancer cell migration and invasion in vitro and metastasis in vivo via the nuclear factor‑κB signaling pathway.
Pin2/TRF1‑binding protein X1 inhibits colorectal cancer cell migration and invasion in vitro and metastasis in vivo via the nuclear factor‑κB signaling pathway. Oncol Rep. 2018 Jul 13;: Authors: Jiang T, Li H, Jiang R, Li H, Hou P, Chen Y, Bai J, Song J Abstract Pin2/TRF1‑binding protein X1 (PinX1) functioned as a potent inhibitor of telomerase, which was also widely considered to be a sufficient tumor suppressor. Previous studies have demonstrated that PinX1 expression was reduced in several types of cancer and was associated with poor overall survival. However, little ...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Analysis of the causes of the misdiagnosis of hereditary spherocytosis.
Authors: Ma S, Deng X, Liao L, Deng Z, Qiu Y, Wei H, Lin F Abstract Hereditary spherocytosis (HS) is an inherited hemolytic disease with clinical diversities. The aim of the present study was to examine the reasons for prolonged misdiagnosis and mistherapy of HS in a Chinese patient, and to summarize the laboratory screening and treatment methods for this disease in increasing the knowledge towards HS. Clinical data of the proband was reviewed. The proband was first screened by detection of eosin-5'-maleimide (EMA)-labeled red blood cells (RBCs) using flow cytometry. The type of protein defect in the extracted RBC ...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation.
Authors: Lin Z, Liu W, Xiao C, Fan Y, Zhuang G, Qi Z Abstract Gastric cancer (GC), a type of gastric mucosal epithelium disease caused by common malignant tumors, has become a major threat to human health and survival. Tumor necrosis factor‑α‑induced protein‑8 like‑2 (TIPE2) is a negative immune regulatory factor that is selectively expressed in immune organs, immune cells and various epithelial cells and serves an important role in the maintenance of human physiological immune homeostasis. In our preliminary study, we found that the expression of TIPE2 was downregulated or absent in GC tissues compar...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

NFIB promotes cell growth, aggressiveness, metastasis and EMT of gastric cancer through the Akt/Stat3 signaling pathway.
Authors: Wu C, Zhu X, Liu W, Ruan T, Wan W, Tao K Abstract Nuclear factor I/B (NFIB) plays a crucial role in the progression of several types of cancers. However, its role in gastric cancer (GC) remains unclear. The present study revealed that NFIB was highly expressed in GC tissues and was positively associated with the clinicopathological features of GC patients. Downregulation of NFIB inhibited the tumor growth, migration and aggression of MKN45 and HGC27 cells in vitro. In addition, NFIB expression promoted epithelial‑mesenchymal transition (EMT), which was accompanied with decreased E‑cadherin an...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing of CDCA5 inhibits cancer progression and serves as a prognostic biomarker for hepatocellular carcinoma.
Authors: Wang J, Xia C, Pu M, Dai B, Yang X, Shang R, Yang Z, Zhang R, Tao K, Dou K Abstract Cell division cycle associated 5 (CDCA5) has been associated with the progression of several types of cancers. However, its possible role and mechanism in hepatocellular carcinoma (HCC) remain unknown. In the present study, immunohistochemical staining and real‑time PCR were used to assess CDCA5 protein and mRNA levels in clinical samples. Statistical analysis was performed to explore the clinical correlation between CDCA5 protein expression and clinicopathological features and overall survival in HCC patients. Cell ...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of long non ‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells.
Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells. Oncol Rep. 2018 Jul 13;: Authors: Yang X, Liu W, Xu X, Zhu J, Wu Y, Zhao K, He S, Li M, Wu Y, Zhang S, Cao J, Ye Z, Xing C Abstract Colorectal cancer (CRC) is the third most commonly diagnosed cancer and common cause of cancer‑related deaths. Radiotherapy has become a routine treatment for CRC. However, radioresistance affects therapeutic efficacy. Long non‑coding RNA urothelial carcinoma associated 1 (UCA1) has been dem...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑320a suppresses tumor cell growth and invasion of human breast cancer by targeting insulin‑like growth factor 1 receptor.
MicroRNA‑320a suppresses tumor cell growth and invasion of human breast cancer by targeting insulin‑like growth factor 1 receptor. Oncol Rep. 2018 Jun 20;: Authors: Guan J, Zhou Y, Mao F, Lin Y, Shen S, Zhang Y, Sun Q Abstract The present study was performed to investigate the biological functions of microRNA‑320a in human breast cancer and the underlying mechanisms. MicroRNA‑320a expression was downregulated in human breast cancer, compared with the normal control. Overexpression of microRNA‑320a induced apoptosis, and inhibited cell viability and invasion in MDA‑MB‑231cells while d...
Source: Oncology Reports - July 11, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Insulin-like growth factor-1 induces epithelial-mesenchymal transition in hepatocellular carcinoma by activating survivin.
In conclusion, survivin may play a vital role in the IGF-1 signaling pathway by mediating EMT in HCC through the upregulation of the expression of EMT markers, and the knockdown of survivin expression may suppress the metastasis of HCC, which may provide new insights for the molecular therapy of HCC patients in clinical treatment. PMID: 29989646 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 11, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Proliferative role of BDNF/TrkB signaling is associated with anoikis resistance in cervical cancer.
Authors: Yuan Y, Ye HQ, Ren QC Abstract Brain‑derived neurotrophic factor (BDNF) is known as one of the members of the neurotropin family. BDNF‑induced activation of its receptor tyrosine kinase B (TrkB) is associated with anoikis tolerance, tumor progression and poor prognosis in many types of malignancy. However, to the best of our knowledge, there are no reports describing the contribution of the BDNF/TrkB axis to cervical cancer. BDNF and TrKB expression in cervical cancer (CC) tissues and adjacent normal tissues from 87 patients were analyzed by immunohistochemistry, western blot analysis and quantitative ...
Source: Oncology Reports - July 11, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LC ‑MS/MS metabolome analysis detects the changes in the lipid metabolic profiles of dMMR and pMMR cells.
This study identified potential anti‑metastatic targets in the therapy of patients with pMMR, and also personalized therapy for the patients with pMMR. PMID: 29989648 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 11, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Systems biology analysis of the lung cancer ‑related secretome.
Systems biology analysis of the lung cancer‑related secretome. Oncol Rep. 2018 Jun 20;: Authors: Feng L, Yang Y, Li M, Song J, Gao Y, Cheng S, Xiao T Abstract Tumorigenesis is closely and highly associated with developmental biology. The present study aimed to discover and identify marker proteins strongly associated with the occurrence and development of non‑small cell lung cancer (NSCLC) in humans and to provide new ideas for investigating lung cancer markers by combining biological analyses of embryonic development. We established primary cultures for samples of tumor and control tissues from 9&...
Source: Oncology Reports - July 11, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Salinomycin induces apoptosis and differentiation in human acute promyelocytic leukemia cells.
Authors: Zhao Y, Zhong L, Liu L, Yao SF, Chen M, Li LW, Shan ZL, Xiao CL, Gan LG, Xu T, Liu BZ Abstract At present, acute promyelocytic leukemia (APL) is the most curable form of acute myeloid leukemia and can be treated using all-trans retinoic acid and arsenic trioxide. However, the current treatment of APL is associated with some issues such as drug toxicity, resistance and relapse. Therefore, other strategies are necessary for APL treatment. In the present study, we investigated the effects of salinomycin (SAL) on APL cell lines NB4 and HL-60 and determined its possible mechanisms. We observed that SAL inhibite...
Source: Oncology Reports - July 11, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Osthole enhances antitumor activity and irradiation sensitivity of cervical cancer cells by suppressing ATM/NF ‑κB signaling.
In conclusion, osthole is an herbal agent that may offer potential for used as an adjuvant treatment for cervical cancer. PMID: 29989651 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 11, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Oxymatrine induces cell cycle arrest and apoptosis and suppresses the invasion of human glioblastoma cells through the EGFR/PI3K/Akt/mTOR signaling pathway and STAT3.
Authors: Dai Z, Wang L, Wang X, Zhao B, Zhao W, Bhardwaj SS, Ye J, Yin Z, Zhang J, Zhao S Abstract Oxymatrine (OM), a natural quinolizidine alkaloid extracted from the traditional Chinese herb Sophora flavescens, has been revealed to produce antitumor activities in various cancer cell lines, including glioblastoma lines, in vitro. However, the mechanisms by which OM exerts its antitumor effect against glioma are poorly understood. The aim of this study was to investigate the role of OM in the proliferation, apoptosis and invasion of glioma cells and to reveal the underlying mechanisms. The effects of OM on U25...
Source: Oncology Reports - July 11, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing of Girdin suppresses the malignant behavior of colorectal carcinoma cells.
Authors: Lu J, Zhang L, Zhou H, Du Z, Zhang G Abstract The aim of the present study was to investigate the effect of the actin‑binding protein Girdin on the proliferation, invasion and migration of colorectal cancer (CRC) cells. Cultured CRC cells (LoVo cell line) were transfected by Girdin‑specific and control shRNA constructs and analyzed for proliferation, invasion and migration by the MTT, Transwell and wound‑healing assays, respectively. The activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway and expression of proinflammatory cytokines was examined...
Source: Oncology Reports - July 11, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel three ‑miRNA signature predicts survival in cholangiocarcinoma based on RNA‑Seq data.
A novel three‑miRNA signature predicts survival in cholangiocarcinoma based on RNA‑Seq data. Oncol Rep. 2018 Jun 27;: Authors: Cao J, Sun L, Li J, Zhou C, Cheng L, Chen K, Yan B, Qian W, Ma Q, Duan W Abstract Accumulating evidence illustrates that many microRNAs (miRNAs) are abnormally expressed in cholangiocarcinoma and play important roles in tumorigenesis, tumor progression and metastasis. These miRNAs may serve as prognostic biomarkers and potential therapeutic targets. The aim of the present study was to identify the differentially expressed miRNAs in cholangiocarcinoma tissues vs. normal tiss...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hydrogen peroxide inhibits the growth of lung cancer cells via the induction of cell death and G1 ‑phase arrest.
In conclusion, H2O2 inhibited the growth of Calu‑6 and A549 lung cancer cells through cell death and G1‑phase arrest. H2O2‑induced cell death resulted from necrosis, as well as caspase‑dependent apoptosis. PMID: 29956787 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DUSP1 induces apatinib resistance by activating the MAPK pathway in gastric cancer.
In conclusion, inducing the downregulation of DUSP1 may be a promising strategy to overcome Apa resistance. PMID: 29956792 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Thymoquinone inhibits metastatic phenotype and epithelial ‑mesenchymal transition in renal cell carcinoma by regulating the LKB1/AMPK signaling pathway.
Thymoquinone inhibits metastatic phenotype and epithelial‑mesenchymal transition in renal cell carcinoma by regulating the LKB1/AMPK signaling pathway. Oncol Rep. 2018 Jun 25;: Authors: Kou B, Kou Q, Ma B, Zhang J, Sun B, Yang Y, Li J, Zhou J, Liu W Abstract Thymoquinone, isolated from the seeds of Nigella sativa, has exhibited antitumor properties in a variety of cancer types. However, few studies have investigated the effect of thymoquinone (TQ) on migration and invasion in renal cell carcinoma (RCC). In the present study, our results confirmed that TQ significantly inhibited the migration and...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer.
Authors: Shi X, Li H, Shi A, Yao H, Ke K, Dong C, Zhu Y, Qin Y, Ding Y, He YH, Liu X, Li L, Lei L, Hai Q, Chen W, Leung KS, Wong MH, Kung HF, Lin MC Abstract Since cyclin‑dependent kinases 4/6 (CDK4/6) play pivotal roles in cell cycle regulation and are overexpressed in human skin cancers, CDK4/6 inhibitors are potentially effective drugs for skin cancer. In the present study, we present a mixed computational and experimental study attempting to repurpose approved small‑molecule drugs as dual CDK4/6 inhibitors for skin cancer treatment. We performed structure‑based virtual screening using the docking sof...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genome ‑wide profiling of lncRNA expression patterns in patients with acute promyelocytic leukemia with differentiation therapy.
Genome‑wide profiling of lncRNA expression patterns in patients with acute promyelocytic leukemia with differentiation therapy. Oncol Rep. 2018 Jun 25;: Authors: Yu J, Guo XL, Bai YY, Yang JJ, Zheng XQ, Ruan JC, Chen ZG Abstract Long non‑coding RNAs (lncRNAs) are crucial factors in acute promyelocytic leukemia (APL) cell differentiation. However, their expression patterns and regulatory functions during all‑trans‑retinoic acid (ATRA)‑induced APL differentiation remain to be fully elucidated. The profile of dysregulated lncRNAs between three bone marrow (BM) samples from patients with APL post...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin ‑resistant oral cancer CAR cells.
Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells. Oncol Rep. 2018 Jun 27;: Authors: Chen CF, Yang JS, Chen WK, Lu CC, Chiang JH, Chiu HY, Tsai SC, Juan YN, Huang HJ, Way TD Abstract Oral squamous cell carcinoma (OSCC) is a type of cancer with high morbidity and mortality rates worldwide; it also demonstrates chemotherapeutic resistance. Triterpenoid ursolic acid has been shown to exhibit various biological activities and anticancer effects in several preclinical studies. In our previous stu...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in  vitro and in vivo by inhibiting the EphA2/Akt signaling pathway.
Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway. Oncol Rep. 2018 Jun 27;: Authors: Chen M, Hu C, Guo Y, Jiang R, Jiang H, Zhou Y, Fu H, Wu M, Zhang X Abstract Lung adenocarcinoma is the most common metastatic cancer, and is associated with high patient mortality. Therefore, investigation of anti‑metastatic treatments for lung adenocarcinoma is crucial. Ophiopogonin B (OP‑B) is a bioactive component of Radix Ophiopogon Japonicus, which is often used in Chinese traditional medicine to treat pulmonary ...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Metformin suppresses the invasive ability of pancreatic cancer cells by blocking autocrine TGF ‑β1 signaling.
Metformin suppresses the invasive ability of pancreatic cancer cells by blocking autocrine TGF‑β1 signaling. Oncol Rep. 2018 Jun 22;: Authors: Duan W, Qian W, Zhou C, Cao J, Qin T, Xiao Y, Cheng L, Li J, Chen K, Li X, Ma J, Ma Q Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive neoplasm with a 5‑year survival rate of
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor ‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer.
Tumor‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer. Oncol Rep. 2018 Jun 27;: Authors: Ji F, Sha H, Meng F, Zhu A, Ding N, Zhang H, Xu H, Qian H, Yu L, Liu Q, Liu B Abstract Radiotherapy has been the primary method for the local control of several types of unresectable tumor, including gastric cancer. Patients with gastric cancer frequently express high levels of epidermal growth factor receptor (EGFR), which have been found to increase following radiotherapy treatment. This provides a basis for the combination of anti...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53.
In conclusion, our results elucidated the importance of S100B in the maintenance of OCSC chemoresistance, which may provide a promising therapeutic target for ovarian cancer. PMID: 29956807 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells.
Authors: Wang R, Li Y, Chen Y, Wang L, Wu Q, Guo Y, Li Y, Liu J, Wang L Abstract RAD54 homolog B is a central motor protein of homologous recombination (HR), which plays an important role in the development and evolution of human cancer. Recent studies have indicated that RAD54B is aberrantly expressed in a variety of cancers and exhibits numerous biological functions, including participating in the repair of DNA double strand breaks. However, the expression and function of RAD54B in liver cancer have not yet been reported. The aim of the present study was to investigate the expression of RAD54B and elucidate its r...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Adiponectin inhibits migration and invasion by reversing epithelial ‑mesenchymal transition in non‑small cell lung carcinoma.
Adiponectin inhibits migration and invasion by reversing epithelial‑mesenchymal transition in non‑small cell lung carcinoma. Oncol Rep. 2018 Jun 25;: Authors: Cui E, Guo H, Shen M, Yu H, Gu D, Mao W, Wang X Abstract Adiponectin is the most abundant adipokine in the tumor microenvironment. The role of this protein in tumor progression, however, remains controversial. In the present study, we aimed to investigate the effects of adiponectin on the abilities of migration and invasion in non‑small cell lung carcinoma (NSCLC). Using NSCLC cell lines, we examined the effects of adiponectin on cell migra...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer.
In conclusion, sex, BMI and age are associated with the incidence and survival rates for cancers. These results could be used to supplement precision and personalized medicine. PMID: 29956810 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑195‑5p regulates multi‑drug resistance of gastric cancer cells via targeting ZNF139.
In conclusion, miR‑195‑5p regulated the MDR of GC cells via targeting ZNF139. PMID: 29956811 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasion.
Authors: Liu M, Zhang X, Cai J, Li Y, Luo Q, Wu H, Yang Z, Wang L, Chen D Abstract TRIM58 is a member of the tripartite motif protein (TRIM) family of E3 ubiquitin ligases. Aberrant gene methylation of TRIM58 has been reported in liver and lung cancer and indicates a poor patient prognosis. However, the expression level and functional role of TRIM58 in colorectal cancer (CRC) have yet to be elucidated. In the present study, we found that TRIM58 expression was significantly suppressed in human CRC and was inversely correlated with CRC progression. Additionally, overall survival was significantly reduced in patients ...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research