Identification of ITGB4 as a novel tumor promoting gene in lung adenocarcinoma (LUAD)
In conclusion, the findings of the present study highlighted the oncogenic function of ITGB4 in LUAD and uncovered potential mechanisms fundamental to the progression of the disease.PMID:38131229 | DOI:10.3892/or.2023.8689 (Source: Oncology Reports)
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Xuan Lu Sai Ma Ying Li Yunzhi Pan Ningning Kang Source Type: research
[Retracted] Isoquercitrin inhibits bladder cancer progression < em > in vitro < /em > and < em > in vivo < /em > by regulating the PI3K/Akt and PKC signaling pathways
Oncol Rep. 2024 Feb;51(2):25. doi: 10.3892/or.2023.8684. Epub 2023 Dec 22.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the agarose gel electrophoretic bands shown in Fig. 4A for PKC were strikingly similar to bands that had already appeared in another article written by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Oncology Reports, the Editor has decided that this paper should be retracted from the Journal. The authors were asked ...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Feng Chen Xiaochi Chen Deyong Yang Xiangyu Che Jianbo Wang Xiancheng Li Zhiwei Zhang Qifei Wang Wei Zheng Lina Wang Xuejian Wang Xishuang Song Source Type: research
Activin A induces apoptosis of human lung adenocarcinoma A549 cells through endoplasmic reticulum stress pathway
Oncol Rep. 2024 Feb;51(2):29. doi: 10.3892/or.2023.8688. Epub 2023 Dec 22.ABSTRACTActivin A, a member of the transforming growth factor‑β (TGF‑β) superfamily, has been implicated in the tumorigenesis and progression of various cancers. However, it remains unclear whether activin A induces apoptosis in human lung adenocarcinoma cells through the endoplasmic reticulum (ER) stress pathway. In the present study, BrdU, flow cytometry and western blotting were used to examine cell proliferation, apoptosis and protein expression, respectively. The present study revealed that activin A inhibited human lung adenocarcinoma A54...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Fenglin Zhang Yan Qi Jing Li Boyang Liu Zhonghui Liu Xueling Cui Source Type: research
Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression
Oncol Rep. 2024 Feb;51(2):27. doi: 10.3892/or.2023.8686. Epub 2023 Dec 22.ABSTRACTUrsolic acid (UA), a natural pentacyclic triterpenoid, is known to exhibit various biological activities and anticancer effects. However, the underlying anticancer mechanism is not fully understood to date. The present study aimed to investigate the antimetastatic effect of UA through ADP‑ribosylation factor like GTPase 4C (ARL4C) in colon cancer. A lung metastasis model of colon cancer in nude mice was established through tail vein injection. A Cell Counting Kit‑8 assay was used to investigate the proliferation of colon cancer cells. Tra...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Mengzhe Zhang Fenfen Xiang Yipeng Sun Rongrong Liu Qian Li Qing Gu Xiangdong Kang Rong Wu Source Type: research
Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)
Oncol Rep. 2024 Feb;51(2):28. doi: 10.3892/or.2023.8687. Epub 2023 Dec 22.ABSTRACTPlasticity, the ability of cancer cells to transition between differentiation states without genomic alterations, has been recognized as a major source of intratumoral heterogeneity. It has a crucial role in cancer metastasis and treatment resistance. Thus, targeting plasticity holds tremendous promise. However, the molecular mechanisms of plasticity in cancer cells remain poorly understood. Several studies found that mRNA, which acts as a bridge linking the genetic information of DNA and protein, has an important role in translating genotype...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Chunzhi Zhang Siyuan Liang Hanning Zhang Ruoxi Wang Huanhuan Qiao Source Type: research
A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut ‑supporting/immune enhancing molecules
Oncol Rep. 2024 Feb;51(2):31. doi: 10.3892/or.2023.8690. Epub 2023 Dec 22.ABSTRACTPatients with end‑stage metastatic disease have limited treatment options and those diagnosed with triple negative breast cancer (Her2, Estrogen receptor, Progesterone receptor) have a poor prognosis. Using a triple negative mammary tumor model selected for brain metastasis (4T1Br4) in the mouse, treatment options that may increase survival when therapeutics are applied at post‑metastasis were assessed. Anti‑parasitic benzimidazoles (BZs) destabilize microtubules, inhibit metabolic pathways, reduce cell proliferation, and induce apoptos...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Vijaya Iragavarapu-Charyulu Rojesh Shakya Philip Robinson Esther Guzm án Anastasia Tyulmenkova Jose Labrador Pino Ceylan Isgor Source Type: research
Rab25 suppresses colon cancer cell invasion through upregulating claudin ‑7 expression
Oncol Rep. 2024 Feb;51(2):26. doi: 10.3892/or.2023.8685. Epub 2023 Dec 22.ABSTRACTRas‑related protein 25 (Rab25) is a member of small GTPase and is implicated in cancer cell progression of various types of cancer. Growing evidence suggests the context‑dependent role of Rab25 in cancer invasiveness. Claudin‑7 is a tight junction protein and has been known to suppress cancer cell invasion. Although Rab25 was reported to repress cancer aggressiveness through recycling β1 integrin to the plasma membrane, the detailed underlying mechanism remains to be elucidated. The present study identified the critical role of claudin...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Su Jin Cho Bo Young Jeong Se-Hee Yoon Chang Gyo Park Hoi Young Lee Source Type: research
Identification of ITGB4 as a novel tumor promoting gene in lung adenocarcinoma (LUAD)
In conclusion, the findings of the present study highlighted the oncogenic function of ITGB4 in LUAD and uncovered potential mechanisms fundamental to the progression of the disease.PMID:38131229 | DOI:10.3892/or.2023.8689 (Source: Oncology Reports)
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Xuan Lu Sai Ma Ying Li Yunzhi Pan Ningning Kang Source Type: research
[Retracted] Isoquercitrin inhibits bladder cancer progression < em > in vitro < /em > and < em > in vivo < /em > by regulating the PI3K/Akt and PKC signaling pathways
Oncol Rep. 2024 Feb;51(2):25. doi: 10.3892/or.2023.8684. Epub 2023 Dec 22.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the agarose gel electrophoretic bands shown in Fig. 4A for PKC were strikingly similar to bands that had already appeared in another article written by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Oncology Reports, the Editor has decided that this paper should be retracted from the Journal. The authors were asked ...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Feng Chen Xiaochi Chen Deyong Yang Xiangyu Che Jianbo Wang Xiancheng Li Zhiwei Zhang Qifei Wang Wei Zheng Lina Wang Xuejian Wang Xishuang Song Source Type: research
Activin A induces apoptosis of human lung adenocarcinoma A549 cells through endoplasmic reticulum stress pathway
Oncol Rep. 2024 Feb;51(2):29. doi: 10.3892/or.2023.8688. Epub 2023 Dec 22.ABSTRACTActivin A, a member of the transforming growth factor‑β (TGF‑β) superfamily, has been implicated in the tumorigenesis and progression of various cancers. However, it remains unclear whether activin A induces apoptosis in human lung adenocarcinoma cells through the endoplasmic reticulum (ER) stress pathway. In the present study, BrdU, flow cytometry and western blotting were used to examine cell proliferation, apoptosis and protein expression, respectively. The present study revealed that activin A inhibited human lung adenocarcinoma A54...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Fenglin Zhang Yan Qi Jing Li Boyang Liu Zhonghui Liu Xueling Cui Source Type: research
Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression
Oncol Rep. 2024 Feb;51(2):27. doi: 10.3892/or.2023.8686. Epub 2023 Dec 22.ABSTRACTUrsolic acid (UA), a natural pentacyclic triterpenoid, is known to exhibit various biological activities and anticancer effects. However, the underlying anticancer mechanism is not fully understood to date. The present study aimed to investigate the antimetastatic effect of UA through ADP‑ribosylation factor like GTPase 4C (ARL4C) in colon cancer. A lung metastasis model of colon cancer in nude mice was established through tail vein injection. A Cell Counting Kit‑8 assay was used to investigate the proliferation of colon cancer cells. Tra...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Mengzhe Zhang Fenfen Xiang Yipeng Sun Rongrong Liu Qian Li Qing Gu Xiangdong Kang Rong Wu Source Type: research
Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)
Oncol Rep. 2024 Feb;51(2):28. doi: 10.3892/or.2023.8687. Epub 2023 Dec 22.ABSTRACTPlasticity, the ability of cancer cells to transition between differentiation states without genomic alterations, has been recognized as a major source of intratumoral heterogeneity. It has a crucial role in cancer metastasis and treatment resistance. Thus, targeting plasticity holds tremendous promise. However, the molecular mechanisms of plasticity in cancer cells remain poorly understood. Several studies found that mRNA, which acts as a bridge linking the genetic information of DNA and protein, has an important role in translating genotype...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Chunzhi Zhang Siyuan Liang Hanning Zhang Ruoxi Wang Huanhuan Qiao Source Type: research
A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut ‑supporting/immune enhancing molecules
Oncol Rep. 2024 Feb;51(2):31. doi: 10.3892/or.2023.8690. Epub 2023 Dec 22.ABSTRACTPatients with end‑stage metastatic disease have limited treatment options and those diagnosed with triple negative breast cancer (Her2, Estrogen receptor, Progesterone receptor) have a poor prognosis. Using a triple negative mammary tumor model selected for brain metastasis (4T1Br4) in the mouse, treatment options that may increase survival when therapeutics are applied at post‑metastasis were assessed. Anti‑parasitic benzimidazoles (BZs) destabilize microtubules, inhibit metabolic pathways, reduce cell proliferation, and induce apoptos...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Vijaya Iragavarapu-Charyulu Rojesh Shakya Philip Robinson Esther Guzm án Anastasia Tyulmenkova Jose Labrador Pino Ceylan Isgor Source Type: research
Rab25 suppresses colon cancer cell invasion through upregulating claudin ‑7 expression
Oncol Rep. 2024 Feb;51(2):26. doi: 10.3892/or.2023.8685. Epub 2023 Dec 22.ABSTRACTRas‑related protein 25 (Rab25) is a member of small GTPase and is implicated in cancer cell progression of various types of cancer. Growing evidence suggests the context‑dependent role of Rab25 in cancer invasiveness. Claudin‑7 is a tight junction protein and has been known to suppress cancer cell invasion. Although Rab25 was reported to repress cancer aggressiveness through recycling β1 integrin to the plasma membrane, the detailed underlying mechanism remains to be elucidated. The present study identified the critical role of claudin...
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Su Jin Cho Bo Young Jeong Se-Hee Yoon Chang Gyo Park Hoi Young Lee Source Type: research
Identification of ITGB4 as a novel tumor promoting gene in lung adenocarcinoma (LUAD)
In conclusion, the findings of the present study highlighted the oncogenic function of ITGB4 in LUAD and uncovered potential mechanisms fundamental to the progression of the disease.PMID:38131229 | DOI:10.3892/or.2023.8689 (Source: Oncology Reports)
Source: Oncology Reports - December 22, 2023 Category: Cancer & Oncology Authors: Xuan Lu Sai Ma Ying Li Yunzhi Pan Ningning Kang Source Type: research
