The prednisolone phosphate ‑induced suppression of the angiogenic function of tumor‑associated macrophages enhances the antitumor effects of doxorubicin on B16.F10 murine melanoma cells in vitro.
The prednisolone phosphate‑induced suppression of the angiogenic function of tumor‑associated macrophages enhances the antitumor effects of doxorubicin on B16.F10 murine melanoma cells in vitro. Oncol Rep. 2019 Oct 01;: Authors: Licarete E, Rauca VF, Luput L, Patras L, Sesarman A, Banciu M Abstract Several lines of evidence have clearly demonstrated the role of the tumor microenvironment in favoring the drug resistance of melanoma cells, as well as the progression of this cancer type. Since our previous studies proved that the accumulation of prednisolone disodium phosphate (PLP) in melanoma t...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma.
In conclusion, the results of the present study suggest the possible involvement of CTGF in the migration‑promoting effect and chemoresistance of EOC, suggesting that it may be a target for overcoming the malignant properties of EOC. PMID: 31578579 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genetic interactions between ANLN and KDR are prognostic for breast cancer survival.
This study contributes to breast cancer prognosis and therapeutic design by providing genetic evidence of interactions between ANLN and KDR, and suggesting the prominent role of the immune response in driving the synergies between the cancer cell life/death and angiogenesis/metastasis transitions during carcinogenesis. PMID: 31578580 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel therapeutic anti ‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells.
A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells. Oncol Rep. 2019 Sep 26;: Authors: Dho SH, Cho EH, Lee JY, Lee SY, Jung SH, Kim LK, Lim JC Abstract In recent years, efforts to treat cancer by improving the immune function of patients have received a great deal of attention. As part of the immune system, complement is also under such evaluation. Among the many components of the complement system, complement decay accelerating factor (CD55 or DAF) is known to inhibit complement‑mediated cell lysis. However, little is known about t...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review).
Authors: Krasanakis T, Nikolouzakis TK, Sgantzos M, Mariolis-Sapsakos T, Souglakos J, Spandidos DA, Tsitsimpikou C, Tsatsakis A, Tsiaoussis J Abstract Colorectal cancer (CRC) is one of the four leading causes of cancer‑related mortality worldwide. Even though over the past few decades the global scientific community has made tremendous efforts to understand this entity, many questions remain to be raised on this issue and even more to be answered. Epidemiological findings have unveiled numerous environmental and genetic risk factors, each one contributing to a certain degree to the final account of new CRC cases....
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Acquisition of temozolomide resistance by the rat C6 glioma cell line increases cell migration and side population phenotype.
Authors: Xu Y, Yang X, Mei S, Sun Y, Li J Abstract Cancer stem cells are reportedly associated with drug resistance in glioma, but there are conflicting findings on the effects of cancer stem cells on drug resistance. The aim of the present study was to identify the underlying mechanisms of drug resistance in rat C6 glioma cells, through the use of Transwell invasion assays, flow cytometric and western blot analyses as well as immunohistochemical staining. The results revealed that acquisition of drug resistance by C6 cells enhanced migration ability in vivo and in vitro. Notably, drug resistance did not ...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High levels of Notch intracellular cleaved domain are associated with stemness and reduced bevacizumab efficacy in patients with advanced colon cancer.
Authors: Negri F, Bozzetti C, Pedrazzi G, Azzoni C, Bottarelli L, Squadrilli A, Lagrasta C, Tamagnini I, Bisagni A, Ragazzi M, Porzio R, Tomasello G, Mori D, Leonardi F, Gnetti L, Crafa P, Sala R, Cascinu S Abstract δ‑like ligand 4 (DLL4)‑Notch signaling is associated with tumor resistance to anti‑vascular endothelial growth factor (VEGF) therapy. Furthermore, Notch signaling is critical for the maintenance of colon cancer stem cells (CSCs), which are relevant in drug resistance and tumor angiogenesis. CD44 is a transmembrane glycoprotein and is considered a putative marker of CSCs. To assess ...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Apurinic endonuclease 1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin ‑mediated mitophagy.
In conclusion, APE1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin‑mediated mitophagy. PMID: 31578585 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Potential role for second ‑generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis.
Potential role for second‑generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis. Oncol Rep. 2019 Sep 27;: Authors: Ishikawa M, Iriyama N, Tokuhira M, Takaku T, Sato E, Sugimoto KJ, Nakazato T, Fujita H, Kimura Y, Fujioka I, Komatsu N, Asou N, Kizaki M, Hatta Y, Kawaguchi T Abstract Tyrosine kinase inhibitor (TKI) treatment is the standard of care for patients with chronic myeloid leukemia (CML). Even in the imatinib era, the presence of 'clonal chromosomal abnormalities...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Activation of the Toll ‑like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro.
Activation of the Toll‑like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro. Oncol Rep. 2019 Sep 27;: Authors: Chen Y, Huang Z, Chen X, Ye H Abstract Toll‑like receptor 2 (TLR2), is an important pattern recognition receptor which serves a role in chronic inflammation of the liver. However, the role of TLR2 in the progression of human hepatocellular carcinoma (HCC) remains unknown. The aim of the present study was to examine the effects of the activation of the TLR2 signaling pathway on biological functions, such as proliferation and apoptosis. TLR2 expression in HCC ti...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Palmitoylome profiling indicates that androgens regulate the palmitoylation of α‑tubulin in prostate cancer‑derived LNCaP cells and supernatants.
Palmitoylome profiling indicates that androgens regulate the palmitoylation of α‑tubulin in prostate cancer‑derived LNCaP cells and supernatants. Oncol Rep. 2019 Sep 24;: Authors: Li W, Zhang J, Zou L, Cui J, Su F, Jin J, Xiao F, Liu M, Zhao G Abstract Prostate cancer is closely associated with constitutive transactivation of the androgen receptor (AR) signaling pathway. After treatment with androgen‑deprivation therapy (ADT), the majority of patients develop castration‑resistant prostate cancer within months or years. In order to investigate potential novel therapeutic targets in additio...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Follistatin ‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway.
Follistatin‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway. Oncol Rep. 2019 Sep 24;: Authors: Peng X, Wang P, Li S, Jiang Y, Wu C Abstract Gastric cancer is an aggressive disease and a common cause of cancer‑associated mortality worldwide. Recent studies have indicated that follistatin‑like protein 1 (FSTL‑1) is expressed and serves essential roles in tumorigenesis; however, the specific functional mechanism of FSTL‑1 in gastric cancer progression remains ambiguous. CellTiter‑Glo Luminescent Cell Viability and lactate dehydrogenase ...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ku80 gene knockdown by the CRISPR/Cas9 technique affects the biological functions of human thyroid carcinoma cells.
Authors: Fan Y, Li J, Wei W, Fang H, Duan Y, Li N, Zhang Y, Yu J, Wang J Abstract In the present study, to evaluate the role of Ku80 in thyroid carcinoma (TC), 86 thyroid tissue samples from patients with a spectrum of thyroid disorders were examined for protein levels of Ku80, nuclear factor‑κB (NF‑κB) and RET/TC by immunohistochemistry. Furthermore, in TC cells, Ku80 mRNA was detected by reverse transcription‑quantitative PCR analysis and silenced using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‑associated protein 9 (Cas9) technique to assess its role. An ant...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DDR1 promotes breast tumor growth by suppressing antitumor immunity.
Authors: Zhong X, Zhang W, Sun T Abstract Breast cancer is the second leading cause of cancer‑associated mortality among women worldwide. Triple‑negative breast cancer (TNBC) accounts for 15‑20% of all breast cancers and is defined by its aggressive nature and limited treatment options. Therefore, there is an urgent need to develop effective therapies for TNBC in order to improve breast cancer outcomes, as targeted therapies have done in other subtypes of breast cancer. Discoidin domain receptor tyrosine kinase 1 (DDR1) is activated by collagens, which are important components of the tumor stroma; t...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cytotoxicity of Cichorium intybus L. metabolites (Review).
Authors: Imam KMSU, Xie Y, Liu Y, Wang F, Xin F Abstract Cichorium intybus L. (Chicory) is a widely distributed, edible, perennial, herbaceous member of the Asteraceae family. Besides its use in modern Chinese herbal medicine, its ethnomedicinal use is evident in the text from ancient Greece, Egypt and China. It is also used as a food and coffee substitute, which is mainly responsible for its extensive domestication. In recent decades, cytotoxic studies of C. intybus extracts have shown its antitumor potential. These studies also identified metabolite constituents including guaianolides, 6‑methoxyflavone, eudesma...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

p53 deficiency augments nucleolar instability after ionizing irradiation.
Authors: Kakoti S, Yamauchi M, Gu W, Kato R, Yasuhara T, Hagiwara Y, Laskar S, Oike T, Sato H, Held KD, Nakano T, Shibata A Abstract Ribosomes are important cellular components that maintain cellular homeostasis through overall protein synthesis. The nucleolus is a prominent subnuclear structure that contains ribosomal DNA (rDNA) encoding ribosomal RNA (rRNA), an essential component of ribosomes. Despite the significant role of the rDNA‑rRNA‑ribosome axis in cellular homeostasis, the stability of rDNA in the context of the DNA damage response has not been fully investigated. In the present study, the number and...
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma.
In conclusion, the present study revealed that upregulation of HHLA2 is significantly associated with a favorable outcome for patients with glioma. Targeting HHLA2 as an immune stimulator may become a valuable approach for the treatment of glioma in clinical practice. PMID: 31578594 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High blood levels of soluble OX40 (CD134), an immune costimulatory molecule, indicate reduced survival in patients with advanced colorectal cancer.
Authors: Sawada R, Arai Y, Sagawa Y, Nagata Y, Nishimura T, Noguchi M, Amano K, Arihiro S, Saruta M, Homma S Abstract The interaction between tumor necrosis factor receptor superfamily, member 4 (OX40) on T cells and the OX40 ligand (OX40L) on antigen‑presenting cells (APCs) is a pivotal step for T‑cell activation and the promotion of antitumor immunity. However, it is hypothesized that soluble OX40 (sOX40) in blood suppresses T‑cell activation by blocking the OX40/OX40L interaction. In the present study, the association between blood sOX40 levels and the clinical characteristics of advanced colorectal cancer...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Synchronous co ‑expression of Id‑1 and nuclear NF‑κB p65 promotes cervical cancer progression and malignancy, and is associated with a poor prognosis and chemosensitivity.
This study aimed to investigate the clinical significance of Id‑1 and NF‑κB p65 in cervical cancer and to elucidate their roles in malignant properties. Paraffin‑embedded cervical tissue specimens (n=85) were collected for immunohistochemistry and survival analysis. Targeting Id‑1 with lentivirus in vitro allowed the examination of the NF‑κB signaling pathway and cell survival. The results demonstrated the elevated co‑expression of Id‑1 and nuclear NF‑κB p65 was more frequently associated with aggressive cervical cancer behavior and poorer clinical outcomes. Targeting Id‑1 with shor...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Increased UCP1 expression in the perirenal adipose tissue of patients with renal cell carcinoma.
In conclusion, high UCP1 expression in the PAT may serve as an indicator of poor prognosis in RCC. PMID: 31545449 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma.
In conclusion, the methylation status of the SARDH‑CGI was identified as an independent prognostic candidate marker for RCC. PMID: 31545450 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gene expression and prognosis of insulin ‑like growth factor‑binding protein family members in non‑small cell lung cancer.
Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. Oncol Rep. 2019 Sep 16;: Authors: Wang J, Hu ZG, Li D, Xu JX, Zeng ZG Abstract Lung cancer is the leading cause of cancer mortality worldwide. Approximately 85% of all lung cancer cases are classified as non‑small cell lung cancer (NSCLC). Currently, there is no standard method to predict the survival of patients with NSCLC. Insulin‑like growth factor‑binding proteins (IGFBPs) function as modulators of IGF signaling and are attracting increasing attention for their role ...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Nicotinamide N ‑methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells.
Nicotinamide N‑methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells. Oncol Rep. 2019 Sep 16;: Authors: Hah YS, Cho HY, Jo SY, Park YS, Heo EP, Yoon TJ Abstract Cutaneous squamous cell carcinoma (cSCC) is a common malignancy initiated by keratinocytes of the epidermis, which are able to invade the dermis and its periphery. Although most patients with cSCC present with curable localized tumors, recurrence, metastasis and mortality occasionally occur. In the present study, nicotinamide N‑methyltransferase (NNMT) was identified as an upregulated protein in the SCC12...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miRNA ‑205‑5p functions as a tumor suppressor by negatively regulating VEGFA and PI3K/Akt/mTOR signaling in renal carcinoma cells.
miRNA‑205‑5p functions as a tumor suppressor by negatively regulating VEGFA and PI3K/Akt/mTOR signaling in renal carcinoma cells. Oncol Rep. 2019 Sep 10;: Authors: Huang J, Wang X, Wen G, Ren Y Abstract MicroRNAs (miRNAs) are involved in the development of various types of cancers. Dysregulation of miR‑205‑5p has been reported in various types of human cancer. However, little is known concerning the role of miR‑205‑5p in renal cell carcinoma (RCC). The pr~esent study was designed to investigate the role of miR‑205‑5p in RCC. The expression of miR‑205‑5p was measured in clear cell re...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulated IGFBP7 facilitates liver metastasis by modulating epithelial ‑mesenchymal transition in colon cancer.
In conclusion, the results of the present study suggested that IGFBP7 may prevent colon cancer metastasis by inhibiting EMT, and serves as a potential diagnostic marker and therapeutic target for patients with colon cancer. PMID: 31545454 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PI3K p110 α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673.
PI3K p110α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673. Oncol Rep. 2019 Sep 13;: Authors: Cao P, Wang Y, Lv Y, Jiang N, Zhong L, Ma X, Xiao X, Ding D, Gu J, Lin L, Li S Abstract Poly(ADP‑ribose) polymerase (PARP) inhibitors have little effect on homologous recombination repair (HRR)‑proficient tumor types, such as cervical cancer. In addition to catalytic activity, the PARP inhibitor, BMN673, traps PARP1 on damaged DNA and induces cytotoxic effects. The aim of the present study was to evaluate the therapeutic effect of PI3K inhi...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Serum proteomic analysis of melanoma patients with immunohistochemical profiling of primary melanomas and cultured cells: Pilot study.
Authors: Kučera J, Strnadová K, Dvořánková B, Lacina L, Krajsová I, Štork J, Kovářová H, Skalníková HK, Vodička P, Motlík J, Dundr P, Smetana K, Kodet O Abstract The steadily increasing incidence of malignant melanoma (MM) and its aggressive behaviour makes this tumour an attractive cancer research topic. The tumour microenvironment is being increasingly recognised as a key factor in cancer biology, with an impact on proliferation, invasion, angiogenesis and metastatic spread, as well as acquired therapy resistance. Multiple bioactive molecul...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA ‑942.
LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA‑942. Oncol Rep. 2019 Sep 12;: Authors: Chen Y, He J, Su C, Wang H, Chen Y, Guo W, Li Y, Ding G Abstract The present study aimed to investigate the potential mechanisms of human miR‑942 in the sunitinib‑resistance of renal cell carcinoma (RCC). A sunitinib‑resistant OS‑RC‑2 cell line was established by continuous exposure to increasing concentrations of sunitinib for ~12 weeks. The expression levels of four miRNAs were determined by reverse transcription‑quantitati...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Metastatic renal cell carcinoma cells growing in 3D on poly ‑D‑lysine or laminin present a stem‑like phenotype and drug resistance.
Metastatic renal cell carcinoma cells growing in 3D on poly‑D‑lysine or laminin present a stem‑like phenotype and drug resistance. Oncol Rep. 2019 Sep 18;: Authors: Brodaczewska KK, Bielecka ZF, Maliszewska-Olejniczak K, Szczylik C, Porta C, Bartnik E, Czarnecka AM Abstract 3D spheroids are built by heterogeneous cell types in different proliferative and metabolic states and are enriched in cancer stem cells. The main aim of the study was to investigate the usefulness of a novel metastatic renal cell carcinoma (RCC) 3D spheroid culture for in vitro cancer stem cell physiology research and dr...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑203a‑3p is a candidate tumor suppressor that targets thrombospondin 2 in colorectal carcinoma.
MicroRNA‑203a‑3p is a candidate tumor suppressor that targets thrombospondin 2 in colorectal carcinoma. Oncol Rep. 2019 Sep 12;: Authors: Qian Z, Gong L, Mou Y, Han Y, Zheng S Abstract The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2017. Total RNA extraction and reverse transcription‑quantitative po...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel deep learning architecture outperforming 'off ‑the‑shelf' transfer learning and feature‑based methods in the automated assessment of mammographic breast density.
In this study, we propose and evaluate advanced machine learning methodologies aiming at an objective and reliable method for breast density scoring from routine mammographic images. The proposed image analysis pipeline incorporates texture [Gabor filters and local binary pattern (LBP)] and gradient‑based features [histogram of oriented gradients (HOG) as well as speeded‑up robust features (SURF)]. Additionally, transfer learning approaches with ImageNet trained weights were also used for comparison, as well as a convolutional neural network (CNN). The proposed CNN model was fully trained on two open mammography datase...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Lung carcinoma therapy using epidermal growth factor receptor ‑targeted lipid polymeric nanoparticles co‑loaded with cisplatin and doxorubicin.
Lung carcinoma therapy using epidermal growth factor receptor‑targeted lipid polymeric nanoparticles co‑loaded with cisplatin and doxorubicin. Oncol Rep. 2019 Sep 18;: Authors: Nan Y Abstract The rate of lung cancer in tuberculosis (TB) patients is 7 to 30% higher than that in healthy individuals. Conventional chemotherapy of lung cancer shows limited efficiency due to poor tumor tissue drug accumulation and nonspecific cytotoxicity. Epidermal growth factor receptor (EGFR) is a promising target, which is overexpressed in lung carcinomas. In the present study, EGFR‑targeted nanopart...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

O ‑GlcNAc modification influences endometrial receptivity by promoting endometrial cell proliferation, migration and invasion.
O‑GlcNAc modification influences endometrial receptivity by promoting endometrial cell proliferation, migration and invasion. Oncol Rep. 2019 Sep 16;: Authors: Han X, Li X, Liu H, Zhang H, Li A, Dong M, Xu Y, Yan B, Sui L, Kong Y Abstract O‑linked β‑N‑acetylglucosamine (O‑GlcNAc) modification is a dynamic post‑translational modification process that is involved in many crucial biological processes, including cell cycle regulation, nutrient metabolism and extracellular signaling. This dynamic modification is dependent on the ambient glucose concentration and is catalyzed and removed by ...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PTEN/AKT signaling mediates chemoresistance in refractory acute myeloid leukemia through enhanced glycolysis.
Authors: Ryu MJ, Han J, Kim SJ, Lee MJ, Ju X, Lee YL, Son JH, Cui J, Jang Y, Chung W, Song IC, Kweon GR, Heo JY Abstract Primary refractory acute myeloid leukemia (AML) and early recurrence of leukemic cells are among the most difficult hurdles to overcome in the treatment of AML. Moreover, uncertainties surrounding the molecular mechanism underlying refractory AML pose a challenge when it comes to developing novel therapeutic drugs. However, accumulating evidence suggests a contribution of phosphatase and tensin homolog (PTEN)/protein kinase B (AKT) signaling to the development of refractory AML. To assess PTEN/AK...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑4712‑5p promotes proliferation of the vulvar squamous cell carcinoma cell line A431 by targeting PTEN through the AKT/cyclin D1 signaling pathways.
MicroRNA‑4712‑5p promotes proliferation of the vulvar squamous cell carcinoma cell line A431 by targeting PTEN through the AKT/cyclin D1 signaling pathways. Oncol Rep. 2019 Sep 17;: Authors: Yang S, Zhao Y, Wang L, Liu C, Lu Y, Fang Z, Shi H, Zhang W, Wu X Abstract The aim of the present study was to screen differentially expressed miRNAs in vulvar squamous cell carcinoma (VSCC), observe the role of microRNA‑4712‑5p in VSCC and investigate its targets and regulatory mechanism. Differentially expressed miRNAs in human VSCC tissues were screened. microRNA‑4712‑5p was selected and its expressi...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma.
Authors: Li H, Long J, Xie F, Kang K, Shi Y, Xu W, Wu X, Lin J, Xu H, Du S, Xu Y, Zhao H, Zheng Y, Gu J Abstract Cholangiocarcinoma (CCA) is acknowledged as the second most commonly diagnosed primary liver tumor and is associated with a poor patient prognosis. The present study aimed to explore the biological functions, signaling pathways and potential prognostic biomarkers involved in CCA through transcriptomic analysis. Based on the transcriptomic dataset of CCA from The Cancer Genome Atlas (TCGA), differentially expressed protein‑coding genes (DEGs) were identified. Biological function enrichment ana...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Clinical significance and biological role of KLF17 as a tumour suppressor in colorectal cancer.
Authors: Jiang X, Shen TY, Lu H, Shi C, Liu Z, Qin H, Wang F Abstract It has been reported that kruppel‑like factor 17 (KLF17) acts as a tumour suppressor in several tissues and cancer cells, however, the molecular roles, the underlying mechanisms and clinical significance of KLF17 in colorectal cancer (CRC) have not been completely elucidated. In the present study, KLF17 protein expression was detected in 140 primary CRCs and paired adjacent non‑tumour tissues using immunohistochemistry with tissue microarrays. The KLF17 mRNA expression was determined in 4 CRC cell lines and 20 pairs of the afor...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The four ‑microRNA signature identified by bioinformatics analysis predicts the prognosis of nasopharyngeal carcinoma patients.
The four‑microRNA signature identified by bioinformatics analysis predicts the prognosis of nasopharyngeal carcinoma patients. Oncol Rep. 2019 Sep 16;: Authors: Zhang S, Yue W, Xie Y, Liu L, Li S, Dang W, Xin S, Yang L, Zhai X, Cao P, Lu J Abstract The aim of the present study was to identify microRNAs (miRNAs) that predict the prognosis of patients with nasopharyngeal carcinoma by integrated bioinformatics analysis. First, the original microarray dataset GSE32960, including 312 nasopharyngeal carcinomas and 18 normal samples, was downloaded from the Gene Expression Omnibus database. In add...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The oncogenic role of NKAP in the growth and invasion of colon cancer cells.
Authors: Shu W, Liu G, Dai Y, Feng A, Chen Z, Han J, Li X Abstract It has been reported that NF‑κB activating protein (NKAP) is a transcriptional repressor of the Notch signaling pathway and is involved in the proliferation and survival of hematopoietic stem cells. In the present study, we aimed to investigate the effect of NKAP on the progression and metastasis of colon cancer. The results of immunohistochemical staining and western blot analysis showed that NKAP was upregulated in colon cancer tissues, and its expression was associated with colon cancer stages. CCK‑8, colony formation, Transwell, and fl...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
Authors: Li Q, Xu A, Chu Y, Chen T, Li H, Yao L, Zhou P, Xu M Abstract Ras‑associated protein 1A (Rap1A) is a member of the Ras subfamily of small GTP‑binding proteins and is found to promote metastasis in several types of cancer. However, the functional role and molecular mechanism of action in Rap1A in esophageal squamous cell carcinoma (ESCC) is not fully understood. In the present study, Rap1A was found to be upregulated in ESCC tissues and its expression was correlated with cancer stage. Functional studies revealed that Rap1A could promote ESCC metastasis by stimulating cell migration and invasio...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

lncRNA ‑u50535 promotes the progression of lung cancer by activating CCL20/ERK signaling.
lncRNA‑u50535 promotes the progression of lung cancer by activating CCL20/ERK signaling. Oncol Rep. 2019 Sep 05;: Authors: Wei W, Zhao X, Zhu J, Zhang L, Chen Y, Zhang B, Li Y, Wang M, Zhang Z, Wang C Abstract The ligand/receptor pair C‑C motif chemokine ligand 20 (CCL20)/C‑C motif chemokine receptor 6 (CCR6) is considered to be highly activated in lung cancer and significantly accelerates lung cancer progression through activation of ERK signaling. In addition, it has been shown that long non‑coding RNA‑u50535 (lncRNA‑u50535) upregulates CCL20 expression and facilitates cancer progression ...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑141 inhibits proliferation, migration and invasion in human hepatocellular carcinoma cells by directly downregulating TGFβR1.
miR‑141 inhibits proliferation, migration and invasion in human hepatocellular carcinoma cells by directly downregulating TGFβR1. Oncol Rep. 2019 Sep 18;: Authors: Zhao Y, Xu Z, Zhou J, Yang H Abstract MicroRNAs (miRNAs) have been demonstrated to have crucial roles in modulating various human cancers. The present study examined the involvement of miR‑141 in modulating the proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells. Notably, the results demonstrated that miR‑141 was significantly downregulated in primary liver tumor tissues from patients compared with ...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Receptor ‑interacting serine/threonine‑protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer.
In conclusion, the current study illustrated the mechanisms by which RIP‑1 regulates VEGF‑C expression, by activating NF‑κB and AP‑1 to combine with the ‑332 to ‑190 nt area of the VEGF‑C promoter. By establishing an orthotopic mouse model of gallbladder cancer tumors, it was further elucidated that RIP‑1 promotes gallbladder cancer metastasis. The findings provide evidence that targeting RIP‑1 may prove to be useful in the treatment of gallbladder cancer. PMID: 31545498 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

RSK4 inhibits breast cancer cell proliferation and invasion in  vitro, and is correlated with estrogen receptor upregulation in breast cancer.
RSK4 inhibits breast cancer cell proliferation and invasion in vitro, and is correlated with estrogen receptor upregulation in breast cancer. Oncol Rep. 2019 Sep 20;: Authors: Huo H, Ye X, Yang H, Li Q, Jiang Y Abstract Estrogen (E2) receptor (ER) upregulation has been associated with tumor progression and is the most commonly used clinical biomarker in breast cancer. X‑linked ribosomal S6 kinase 4 (RSK4) is downregulated in breast cancer and may act as a tumor suppressor gene. In order to understand the association between the ER and RSK4, the present study studied the effects of RSK4 on E...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Core ‑shell type thermo‑nanoparticles loaded with temozolomide combined with photothermal therapy in melanoma cells.
Core‑shell type thermo‑nanoparticles loaded with temozolomide combined with photothermal therapy in melanoma cells. Oncol Rep. 2019 Sep 20;: Authors: Hou X, Pang Y, Li X, Yang C, Liu W, Jiang G, Liu Y Abstract A novel core‑shell type thermo‑nanoparticle (CSTNP) co‑loaded with temozolomide (TMZ) and the fluorescein new indocyanine green dye IR820 (termed IT‑CSTNPs) was designed and combined with a near‑infrared (NIR) laser to realize its photothermal conversion. The IT‑CSTNPs were prepared using a two‑step synthesis method and comprised a thermosensitive shell and a biodegradable core....
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma.
Authors: Li S, Jiang Z, Li Y, Xu Y Abstract The minichromosome maintenance (MCM) gene family plays an essential role in DNA replication and cell cycle progression. However, MCM gene expression has not been well‑studied in lung adenocarcinoma (LUAD). In the present study, the expression, prognostic value and functions of MCMs in LUAD were investigated using several databases and bioinformatic tools, including Oncomine, GEPIA, cBioPortal, CancerSEA and Kaplan‑Meier plotter. It was demonstrated that the mRNA expression of MCM2, MCM4 and MCM10 were significantly increased in patients with LUAD. High mRNA expression...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Knockdown of Nedd8 ‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells.
Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells. Oncol Rep. 2019 Sep 20;: Authors: Zhao B, Gao C, Shi D, Mao J, Zhao J, Guo L, Guo J, Jiao Z Abstract As an important regulator of neddylation, neural precursor cell expressed developmentally downregulated 8 (Nedd8)‑conjugating enzyme E2M (UBE2M) mediates cullin neddylation. Upregulation of the neddylation pathway is associated with tumor progression in intrahepatic cholangiocarcinoma (ICC). The present study was designed to assess the effects of Nedd...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Diagnostic and prognostic values of C ‑X‑C motif chemokine ligand 3 in patients with colon cancer.
Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer. Oncol Rep. 2019 Sep 19;: Authors: Ruan GT, Gong YZ, Liao XW, Wang S, Huang W, Wang XK, Zhu GZ, Liao C, Gao F Abstract The diagnostic and prognostic mechanisms of C‑X‑C motif chemokine ligand 3 (CXCL3) in colon cancer (CC) have not yet been reported. Therefore, the objective of the present study was to use cohorts of patients from Guangxi Medical University and the Gene Expression Omnibus (GEO) database to investigate and validate CXCL3 for the diagnosis and prognosis of CC, and to explore its prosp...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer.
Authors: Tan WX, Xu TM, Zhou ZL, Lv XJ, Liu J, Zhang WJ, Cui MH Abstract Cisplatin is a common chemotherapeutic agent against ovarian cancer; however, drug resistance is a major limiting factor for its use in clinical treatment. The underlying mechanisms of cisplatin resistance in ovarian cancer have not yet been fully elucidated. Thus, this study aimed to elucidate some of the mechanisms responsible for resistance to cisplatin in ovarian cancer. The results demonstrated that the cisplatin‑resistant human ovarian cancer cell lines, SKOV3/DDP and A2780/DDP, exhibited higher autophagy levels than the control ovaria...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SMC1 promotes proliferation and inhibits apoptosis through the NF ‑κB signaling pathway in colorectal cancer.
SMC1 promotes proliferation and inhibits apoptosis through the NF‑κB signaling pathway in colorectal cancer. Oncol Rep. 2019 Aug 08;: Authors: Li J, He J, Wang Y, Shu Y, Zhou J Abstract Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer‑associated mortality globally. Increasing evidence has indicated that structural maintenance of chromosomes 1 (SMC1) may serve an important role in solid tumors as a tumor enhancer. In the present study, it was identified via reverse transcription‑quantitative PCR and western blot analyses that expression of SMC1 was s...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research