Comparative proteomic analysis identifies exosomal Eps8 protein as a potential metastatic biomarker for pancreatic cancer.
Authors: Ohshima K, Hatakeyama K, Kanto K, Ide T, Watanabe Y, Moromizato S, Wakabayashi-Nakao K, Sakura N, Yamaguchi K, Mochizuki T Abstract Exosomes are small vesicles found in extracellular environments including blood, urine, and cell culture medium. Their contents are cell‑type specific, and molecules embedded in exosomes can be useful fluid‑based clinical biomarkers. To identify proteins with metastatic marker potential, we conducted a comparative exosomal proteome analysis using human pancreatic cancer cell lines derived from metastasis, ascites, and primary tumors. Metastatic potential of cell lines was ...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Epigenetic knockdown of Notch1 inhibits hepatitis B virus X protein ‑induced hepatocarcinogenesis of L02/HBx cells.
Epigenetic knockdown of Notch1 inhibits hepatitis B virus X protein‑induced hepatocarcinogenesis of L02/HBx cells. Oncol Rep. 2018 Nov 15;: Authors: Peng Y, Zhou D, Ye Y, Kai C, Jiang Z, Zhu Z, Wu X, Xiong J Abstract The present study aimed to investigate the effects of Notch1 on the development of hepatitis B virus X protein (HBx)‑induced hepatocarcinogenesis. The L02/HBx cells were transfected with a short hairpin RNA (shRNA) specially targeting Notch1 (Notch1‑shRNA). The mRNA and protein expression levels of Notch1 signaling pathway‑related molecules (Notch1, Hes1 and NICD) were detected aft...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells.
Authors: Yanagawa-Matsuda A, Mikawa Y, Habiba U, Kitamura T, Yasuda M, Towfik-Alam M, Kitagawa Y, Minowa K, Shindoh M, Higashino F Abstract AU-rich elements (AREs) are RNA elements that enhance the rapid decay of mRNA. The fate of ARE-mRNA is controlled by ARE-binding proteins. HuR, a member of the embryonic lethal abnormal vision (ELAV) family of RNA-binding proteins, is involved in the export and stabilization of ARE-mRNA. In the vast majority of cancer cells, HuR constitutively relocates to the cytoplasm, resulting in the stabilization of ARE-mRNA. Previously, we described that the adenovirus gene product, E4orf...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Exosomes derived from PM2.5 ‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway.
Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway. Oncol Rep. 2018 Nov 09;: Authors: Xu H, Jiao X, Wu Y, Li S, Cao L, Dong L Abstract Fine particulate matter (PM2.5) is associated with an increased lung cancer risk. However, the effect of PM2.5 exposure on lung cancer cells is still largely unknown. The present study revealed that A549 lung cancer cells secreted exosomes containing high levels of Wnt3a after treatment with PM2.5. These exosomes activated β‑catenin signalling in A549 cells. These exosomes exhibited no ...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells.
Authors: Chen X, Song L, Hou Y, Li F Abstract Increased production of reactive oxygen species (ROS) is a distinct feature of various types of cancer. ROS drive tumor progression and render cancer cells vulnerable to additional oxidative insult. The various natural herb compounds have been shown to induce additional production of ROS in cancer cells, although the physiological implications of ROS under these conditions are not fully determined. In the present study, icaritin, a natural compound derived from the medicinal plants Epimedium, was demonstrated to potently suppresses the proliferation of human HeLa and Si...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

ERK5 ‑regulated RERG expression promotes cancer progression in prostatic carcinoma.
ERK5‑regulated RERG expression promotes cancer progression in prostatic carcinoma. Oncol Rep. 2018 Nov 05;: Authors: Xiong Y, Huang H, Chen S, Dai H, Zhang L Abstract Big mitogen‑activated protein kinase 1 [also named extracellular signal‑regulated kinase (ERK) 5] is activated by mitogens and oncogenic signals and is strongly implicated in tumorigenesis. Our previous investigation indicated that ERK5 can induce prostatic carcinoma cell proliferation by promoting entry into the S phase of the cell cycle. In the present study, microarray and western blot analysis revealed that ERK5 can inhibit...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKT inhibitor  MK2206 in mammary cancer models.
[Corrigendum] Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKT inhibitor MK2206 in mammary cancer models. Oncol Rep. 2018 Oct 17;: Authors: Lubet RA, Steele VE, Juliana MM, Bode A, Moeinpour F, Grubbs CJ Abstract The AKT inhibitor employed in this article was identified as MK 2206 (8‑[4‑(1‑aminocyclobutyl) phenyl]‑9‑phenyl‑1,2,4‑ triazolo[3,4‑f][1,6]naphthyridin‑3(2H)‑one hydrochloride (1:2). However, another AKT inhibitor was actually used, which is typically identified as Akt I‑1,2 (HC,I. IPA (2‑[4‑(3‑phenylquinoxalin‑2‑yl)phenyl]...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑301a targets WNT1 to suppress cell proliferation and migration and enhance radiosensitivity in esophageal cancer cells.
MicroRNA‑301a targets WNT1 to suppress cell proliferation and migration and enhance radiosensitivity in esophageal cancer cells. Oncol Rep. 2018 Oct 16;: Authors: Su H, Wu Y, Fang Y, Shen L, Fei Z, Xie C, Chen M Abstract Esophageal cancer (EC) is one of the leading causes of death among malignancies. Radiotherapy for esophageal squamous cell carcinoma (ESCC) patients is limited by resistance to ionizing radiation (IR). An increasing body of evidence has demonstrated that aberrant expression of microRNA‑301a (miR‑301a) contributes to cancer progression and sensitivity to radiation. The aim of the ...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Signaling pathway inhibitors target breast cancer stem cells in triple-negative breast cancer.
Authors: Li W, Yang H, Li X, Han L, Xu N, Shi A Abstract The present study aimed to investigate the efficacy of five signaling pathway inhibitors, N-[N-(3,5‑difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, vismodegib, salinomycin, ruxolitinib and stattic, as novel therapeutic agents that target breast cancer stem cells (BCSCs) in triple-negative breast cancer (TNBC). The in vitro anti-proliferative, anti-invasive, pro-apoptotic and inhibitory effects on BCSC self-renewal of these signaling pathway inhibitors on the TNBC stem cell line HCC38 were examined by MTT assays, Matrigel invasion assays, f...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1.
Authors: Huang Z, Liang X, Wu W, Chen X, Zeng Q, Yang M, Ge J, Xia R Abstract The Snail family transcriptional repressor 1 gene (Snail1) was screened in multiple myeloma cells (MMCs) from bortezomib-resistant MM patients and was found to be significantly associated with the development of drug-resistance mechanisms. In the present study, we first confirmed that the protein expression of Snail1 in bortezomib-resistant MMCs was significantly higher than that in MMCs without bortezomib resistance. The mechanistic studies confirmed that the enhancement of Snail1 expression in bortezomib-resistant MMCs directly upregula...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-296 inhibits colorectal cancer cell growth and enhances apoptosis by targeting ARRB1-mediated AKT activation.
Authors: Zhang Z, Zhong X, Xiao Y, Chen C Abstract Colorectal cancer (CRC) is the most commonly diagnosed tumor worldwide. However, the molecular mechanisms and biological processes of CRC remain unknown. The present study used reverse transcription-quantitative polymerase chain reaction to determine the expression levels of microRNA (miR)-296 in CRC cell lines and tissues. In addition, a miR-296 mimic was transfected into CRC cells, and the effects of miR-296 on cell proliferation and apoptosis were explored by MTT assay and flow cytometry. Luciferase assays were also performed to validate arrestin β1 (ARRB1)...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Osimertinib (AZD9291) increases radio ‑sensitivity in EGFR T790M non‑small cell lung cancer.
Osimertinib (AZD9291) increases radio‑sensitivity in EGFR T790M non‑small cell lung cancer. Oncol Rep. 2018 Oct 17;: Authors: Wang N, Wang L, Meng X, Wang J, Zhu L, Liu C, Li S, Zheng L, Yang Z, Xing L, Yu J Abstract Osimertinib (AZD9291) is a third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that has demonstrated significant clinical benefits in patients with EGFR‑sensitizing mutations or the T790M mutation. However, the potential therapeutic effect of osimertinib combined with ionizing irradiation (IR) is not well understood. The present study investigated treat...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow ‑induced chemoresistance in acute leukemias.
Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow‑induced chemoresistance in acute leukemias. Oncol Rep. 2018 Oct 18;: Authors: Pillozzi S, Bernini A, Spiga O, Lelli B, Petroni G, Bracci L, Niccolai N, Arcangeli A Abstract Notable advances in treatment have been made and increases in the cure rates of pediatric leukemia have been achieved. However, the majority of children with relapsed disease are not expected to survive, with chemotherapy resistance acting as the principal cause of treatment failure. Interaction between leukemic cells and the bone marrow microenvironm...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Malignant gliomas can be converted to non ‑proliferating glial cells by treatment with a combination of small molecules.
Malignant gliomas can be converted to non‑proliferating glial cells by treatment with a combination of small molecules. Oncol Rep. 2018 Oct 25;: Authors: Oh J, Kim Y, Baek D, Ha Y Abstract Gliomas, the most highly malignant central nervous system tumors, are associated with an extremely poor patient survival rate. Given that gliomas are derived from mutations in glial precursor cells, a considerable number of them strongly react with glial precursor cell‑specific markers. Thus, we investigated whether malignant gliomas can be converted to glial cells through the regulation of endogenous gene expres...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Novel 2,3 ‑disubstituted 1,3‑thiazolidin‑4‑one derivatives as potential antitumor agents in renal cell adenocarcinoma.
Novel 2,3‑disubstituted 1,3‑thiazolidin‑4‑one derivatives as potential antitumor agents in renal cell adenocarcinoma. Oncol Rep. 2018 Oct 16;: Authors: Gawrońska-Grzywacz M, Popiołek Ł, Natorska-Chomicka D, Piątkowska-Chmiel I, Izdebska M, Herbet M, Iwan M, Korga A, Dudka J, Wujec M Abstract Cancer represents one of the main causes of mortality in developed countries. In particular, the overall survival of patients with renal cell carcinoma (RCC) remains poor and the available cytostatic agents are insufficient. Therefore, there is an urgent requirement to identify more effective and safer ...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Galla  Rhois water extract inhibits lung metastasis by inducing AMPK‑mediated apoptosis and suppressing metastatic properties of colorectal cancer cells.
Galla Rhois water extract inhibits lung metastasis by inducing AMPK‑mediated apoptosis and suppressing metastatic properties of colorectal cancer cells. Oncol Rep. 2018 Oct 22;: Authors: Mun JG, Kee JY, Han YH, Lee S, Park SH, Jeon HD, Hong SH Abstract Galla Rhois is a commonly used medicine in East Asia for the treatment of several diseases. However, the effects of Galla Rhois on the metastasis of colorectal cancer (CRC) and the underlying molecular mechanisms have not been studied. We investigated the anti‑metastatic properties of Galla Rhois water extract (GRWE) on metastatic...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Vorinostat enhances gefitinib ‑induced cell death through reactive oxygen species‑dependent cleavage of HSP90 and its clients in non‑small cell lung cancer with the EGFR mutation.
Vorinostat enhances gefitinib‑induced cell death through reactive oxygen species‑dependent cleavage of HSP90 and its clients in non‑small cell lung cancer with the EGFR mutation. Oncol Rep. 2018 Oct 22;: Authors: Park SE, Kim DE, Kim MJ, Lee JS, Rho JK, Jeong SY, Choi EK, Kim CS, Hwang JJ Abstract Although different mechanisms of acquired resistance to epidermal growth factor receptor (EGFR)‑tyrosine kinase inhibitors (TKIs) have been reported in non‑small cell lung cancers (NSCLCs), the optimal treatment for patients with acquired resistance has not been clearly defined. The purpose of this ...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway.
Authors: Luo G, Feng R, Sun Y, Zheng L, Wang Y, Chen Y, Wen T Abstract Neuroblastoma (NB) is the most common extracranial solid tumor that affects mainly children and has extremely high mortality and recurrence rates. A previous study revealed that dendritic cell factor 1 (DCF1), also called transmembrane protein 59, could activate apoptosis in glioma cells. In the present study, we applied immunofluorescence, western blot analysis, flow cytometry and cell tumorigenicity to investigate the DCF1 mechanisms involved in NB apoptosis. DCF1 was overexpressed in Neuro-2a and SK-N-SH cells through instantaneous transfecti...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SND1 promotes the proliferation of osteosarcoma cells by upregulating COX ‑2/PGE2 expression via activation of NF‑κB.
SND1 promotes the proliferation of osteosarcoma cells by upregulating COX‑2/PGE2 expression via activation of NF‑κB. Oncol Rep. 2018 Oct 24;: Authors: Zhou M, Wang A, Yin B, Wu D, Han S, Zhang W, Liu J, Sun K Abstract Osteosarcoma is the most frequent primary bone tumor. Staphylococcal nuclease domain‑containing 1 (SND1) is a multifunctional protein that plays important roles in tumor development and progression. Overexpression of SND1 has been found in several malignancies, however, its expression and function in osteosarcoma is largely unknown. In the present study, we firstly examin...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑876‑5p inhibits the progression of glioblastoma multiforme by directly targeting Forkhead box M1.
MicroRNA‑876‑5p inhibits the progression of glioblastoma multiforme by directly targeting Forkhead box M1. Oncol Rep. 2018 Oct 17;: Authors: Wang L, Lu J, Zhang H, Lyu X, Sun Z Abstract Considerable evidence has suggested that microRNAs (miRNAs) are dysregulated in glioblastoma multiforme (GBM), and their dysregulation may modulate the aggressiveness of GBM. Therefore, miRNAs with dysregulated expression are potential therapeutic targets for the treatment of GBM. miRNA‑876‑5p (miR‑876‑5p) has recently been identified to be aberrantly expressed and serve an important role in hepatocellu...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Progress of immune checkpoint therapy in the clinic (Review).
Authors: Fan Y, Zhang C, Jin S, Gao Z, Cao J, Wang A, Li D, Wang Q, Sun X, Bai D Abstract Cancer cells can escape antitumor immune responses by exploiting inhibitory immune checkpoints. Immune checkpoint therapy, mainly including anti‑CTLA‑4 therapy and anti‑PD‑1/PD‑L1 therapy, can enhance antitumor immune responses by blocking the inhibitory signals of the immune system. This therapy has produced clinical advances in a fraction of patients. Deeper insight into the tumor microenvironment and immune checkpoint inhibitors will improve this therapy. Here, we review immune checkpoint inhibitors that prevent t...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway.
Authors: Tang B, Liang W, Liao Y, Li Z, Wang Y, Yan C Abstract Liver metastasis is one of the major causes of death in patients with colorectal cancer, and although treatment has improved recently, the long‑term survival rate of patients has not improved significantly. In the present study, we used immunohistochemistry to determine that phosphoprotein enriched in astrocytes‑15 kDa (PEA15) was highly expressed in colorectal cancer tissues and liver metastatic cancer tissues. It was also highly expressed in metastatic colorectal cancer patients compared to non‑metastatic patients. Through clinicopathologic...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

BRMS1 participates in regulating cell sensitivity to DNA interstrand crosslink damage by interacting with FANCI.
Authors: Dou J, Zhou Y, Liu X, Qiao X, Yang X, Xie W, Qiao S, Wu Y Abstract Breast cancer metastasis suppressor 1 (BRMS1) is a tumor metastasis suppressor implicated in multiple steps during the metastatic cascade. Many proteins interacting with BRMS1 have been identified to unravel the intracellular signaling mechanisms. In the present study, we report that FANCI is a novel interacting protein of BRMS1 as determined by co‑immunoprecipitation assay. The linker region between two coiled‑coil motifs of BRMS1 is required for BRMS1‑FANCI interaction. FANCI is an essential protein in the Fanconi anemia (FA) p...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA ‑494 promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of rapamycin pathway by phosphatase and tensin homolog expression.
MicroRNA‑494 promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of rapamycin pathway by phosphatase and tensin homolog expression. Oncol Rep. 2018 Oct 25;: Authors: Han K, Li ZJ, Sun P Abstract The aim of the present study was to analyze the possible association between microRNA‑494 (miR‑494) and cell proliferation in glioma cancer. Firstly, the expression of miR‑494 was revealed to be upregulated in patients with glioma, compared with the normal group. Next, anti‑miR‑494 mimics were used to decrease the expression of m...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of a 5 ‑microRNA signature and hub miRNA‑mRNA interactions associated with pancreatic cancer.
Identification of a 5‑microRNA signature and hub miRNA‑mRNA interactions associated with pancreatic cancer. Oncol Rep. 2018 Oct 24;: Authors: Ma X, Tao R, Li L, Chen H, Liu Z, Bai J, Shuai X, Wu C, Tao K Abstract miRNA‑gene axes have been reported to serve an important role in the carcinogenesis of pancreatic cancer (PC). The aim of the present study was to systematically identity the microRNA signature and hub molecules, as well as hub miRNA‑gene axes, and to explore the potential biomarkers and mechanisms associated with the carcinogenesis of PC. Eleven microRNA profile datasets were obtained...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

COL ‑3 enhances the anti‑proliferative and pro‑apoptotic effects of paclitaxel in breast cancer cells.
In conclusion, the combination of paclitaxel and COL‑3 indicated additive to synergistic anti‑proliferative effects on breast cancer cells mediated partially via the induction of apoptosis. The combination regimen could further inhibit invasion and metastasis. Thus, COL‑3 could be a beneficial adjunct to a paclitaxel‑based anticancer regimen to improve therapeutic outcome and reduce the adverse effects of paclitaxel, primarily PINP. PMID: 30365135 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑101 regulates the cell proliferation and apoptosis in diffuse large B‑cell lymphoma by targeting MEK1 via regulation of the ERK/MAPK signaling pathway.
miR‑101 regulates the cell proliferation and apoptosis in diffuse large B‑cell lymphoma by targeting MEK1 via regulation of the ERK/MAPK signaling pathway. Oncol Rep. 2018 Oct 24;: Authors: Huang Y, Zou Y, Lin L, Ma X, Zheng R Abstract MAPK kinase 1 (MEK1) is an upstream protein kinase of extracellular signal regulated kinase (ERK), which activates the ERK/MAPK (mitogen activated protein kinase) pathway. Importantly, bioinformatic analysis has shown that there is a target complementary binding site between miR‑101 and MEK1. The present study aimed to ascertain whether or not miR‑101 plays ...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Oncolytic cancer therapy with a vaccinia virus strain.
In this study, the oncolytic efficacy of VG9 was evaluated. We examined in vitro replication and cytotoxicity, in vivo biodistribution, and antitumor effects in a B16 tumor model. The results revealed that VG9 replicated rapidly, but the cytotoxicity varied in different cell lines. Significant antitumor effects of VG9 were observed in a murine melanoma tumor model, and an antitumor cytotoxic T‑lymphocyte response induced by VG9 was also observed. The results indicated that the Chinese vaccinia strain VG9 holds promise in the construction of a recombinant vaccinia virus vector and as a potential therapeutic strategy in ca...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of miR ‑505‑3p predicts poor bone metastasis‑free survival in prostate cancer.
Downregulation of miR‑505‑3p predicts poor bone metastasis‑free survival in prostate cancer. Oncol Rep. 2018 Oct 25;: Authors: Tang Y, Wu B, Huang S, Peng X, Li X, Huang X, Zhou W, Xie P, He P Abstract The principal issue deriving from prostate cancer (PCa) is its propensity to metastasize to bone. To date, bone metastasis remains incurable, and therapeutic strategies are limited. Therefore, it is of paramount importance to explore predictive markers for bone metastasis of PCa. In the present study, we reported that miR‑505‑3p was significantly downregulated in bone metastatic PCa tissues com...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

RGS5 decreases the proliferation of human ovarian carcinoma ‑derived primary endothelial cells through the MAPK/ERK signaling pathway in hypoxia.
RGS5 decreases the proliferation of human ovarian carcinoma‑derived primary endothelial cells through the MAPK/ERK signaling pathway in hypoxia. Oncol Rep. 2018 Oct 22;: Authors: Wang D, Xu Y, Feng L, Yin P, Song SS, Wu F, Yan P, Liang Z Abstract Regulator of G‑protein signaling 5 (RGS5), a tissue‑specific signal‑regulating molecule, plays a key role in the development of the vasculature. It was recently found that RGS5 is abundantly expressed in epithelial ovarian cancer (EOC) compared with the normal ovaries. However, the distribution of RGS5 in EOC and its significance require further inve...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer.
Authors: Chen W, Fan W, Ru G, Huang F, Lu X, Zhang X, Mou X, Wang S Abstract Pancreatic cancer (PC) is a lethal solid malignancy with resistance to traditional chemotherapy. Recently, considerable studies have demonstrated the ubiquitous antitumor properties of gene therapy mediated by the oncolytic vaccinia virus. The second mitochondrial‑derived activator of caspase (Smac) has been identified as an innovative tumor suppressor that augments the chemosensitivity of cancer cells. However, the therapeutic value of oncolytic vaccinia virus (oVV)‑mediated Smac gene transfer in pancreatic cancer is yet to be elucida...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

OBP ‑801, a novel histone deacetylase inhibitor, induces M‑phase arrest and apoptosis in rhabdomyosarcoma cells.
This study aimed to investigate the potential of a novel HDAC inhibitor, OBP‑801, as a therapeutic agent for the treatment of RMS. We used 8 RMS cell lines in this study. Protein expression patterns, cell proliferation, cell cycle status, and apoptosis in RMS cells after OBP‑801 treatment in vitro were investigated. We also studied the antitumor activity of OBP‑801 in an in vivo xenograft mouse model. We observed cell cycle arrest at the M‑phase and apoptosis in all RMS cell lines after exposure to pharmacological levels of OBP‑801 for 24 h. Immunofluorescence staining revealed that OBP‑801 may i...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Two prostate cancer ‑associated polymorphisms in the 3'UTR of IGF1R influences prostate cancer susceptibility by affecting miRNA binding.
Two prostate cancer‑associated polymorphisms in the 3'UTR of IGF1R influences prostate cancer susceptibility by affecting miRNA binding. Oncol Rep. 2018 Oct 22;: Authors: Wang H, Huang W, Yu X, Li W, Huang Y, Mo Z, Gao Y, Zhou Q, Hu Y Abstract Prostate cancer (PCa) is a common malignant cancer in men worldwide. Numerous genetic variations have been associated with PCa, but their biological function remains unclear. Single nucleotide polymorphisms (SNPs) inside 3' untranslated region (UTR) affect gene expression, with one essential mechanism being regulation by micro (mi)RNAs. Based on data from ...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

I157172, a novel inhibitor of cystathionine γ-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3.
I157172, a novel inhibitor of cystathionine γ-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3. Oncol Rep. 2018 Oct 16;: Authors: Wang L, Shi H, Zhang X, Zhang X, Liu Y, Kang W, Shi X, Wang T Abstract Cystathionine γ-lyase (CSE) is highly expressed in breast cancer, and can promote breast cancer development and progression; therefore, inhibitors of CSE may be of great significance for the treatment of breast cancer. The present study identified the CSE inhibitor I157172 through virtual screening and confirmed its activity. Subsequently, t...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

E26 transformation (ETS) ‑specific related transcription factor‑3 (ELF3) orchestrates a positive feedback loop that constitutively activates the MAPK/Erk pathway to drive thyroid cancer.
In conclusion, the present study demonstrated ELF3 to be a potential prognostic marker for patients with thyroid cancer. Notably, ELF3 was demonstrated to form a positive feedback loop with MAPK pathways leading to the progression of BRAF‑mutant thyroid cancer. PMID: 30365150 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Non ‑invasive monitoring of cisplatin and erlotinib efficacy against lung cancer in orthotopic SCID mouse models by small animal FDG‑PET/CT and CT.
Non‑invasive monitoring of cisplatin and erlotinib efficacy against lung cancer in orthotopic SCID mouse models by small animal FDG‑PET/CT and CT. Oncol Rep. 2018 Oct 24;: Authors: Otani T, Kondo K, Takizawa H, Kajiura K, Fujino H, Otsuka H, Miyoshi H Abstract We established patient‑like models of lung cancer metastasis by orthotopically implanting human non‑small cell lung cancer cell lines into SCID mice. We evaluated the utilities of small‑animal computed tomography (CT) and positron‑emission tomography‑computed tomography (PET/CT) in these models to non‑invasively and repeatedly mon...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CCL9/CCR1 induces myeloid ‑derived suppressor cell recruitment to the spleen in a murine H22 orthotopic hepatoma model.
CCL9/CCR1 induces myeloid‑derived suppressor cell recruitment to the spleen in a murine H22 orthotopic hepatoma model. Oncol Rep. 2018 Oct 18;: Authors: Li B, Zhang S, Huang N, Chen H, Wang P, Yang J, Li Z Abstract Myeloid‑derived suppressor cells (MDSCs) are the major negative regulators of immune responses and expand in numerous tumor models. They contribute to tumor progression and metastasis, and are involved in limiting the effects of cancer immunotherapy. To selectively target MDSCs, it is required to understand the molecular mechanisms that drive MDSC expansion. The mechanisms of their ...
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ginkgolic acid suppresses the invasion of HepG2 cells via downregulation of HGF/c ‑Met signaling.
Ginkgolic acid suppresses the invasion of HepG2 cells via downregulation of HGF/c‑Met signaling. Oncol Rep. 2018 Oct 12;: Authors: Li H, Meng X, Zhang D, Xu X, Li S, Li Y Abstract Liver cancer is one of the most devastating types of cancer worldwide. Despite years of improvements in treatment, the prognosis of patients with this type of malignancy remains poor due to frequent recurrence and metastasis after surgical resection. Ginkgolic acid (GA) is a botanical drug extracted from the seed coat of Ginkgo biloba L. that possesses a wide range of bioactive properties. However, to the best of our k...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Phosphorylation of nucleolin is indispensable to its involvement in the proliferation and migration of non-small cell lung cancer cells.
Authors: Huang F, Wu Y, Tan H, Guo T, Zhang K, Li D, Tong Z Abstract Non-small cell lung cancer (NSCLC) is one of the mostly deadly malignancies in the world. Nucleolin is a multifunctional protein that mainly regulates ribosome biogenesis but also has other functions including modulating the transcription of mRNAs and repressing RNA polymerase II. Nucleolin is overexpressed in various cancer cells, including NSCLC cells. It can confer resistance to apoptosis and promote cell migration and blood vessel formation by directly taking part in various tumor signal transduction pathways. The activities of nucleolin ...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Metformin suppresses gastric cancer progression through calmodulin ‑like protein 3 secreted from tumor‑associated fibroblasts.
Metformin suppresses gastric cancer progression through calmodulin‑like protein 3 secreted from tumor‑associated fibroblasts. Oncol Rep. 2018 Oct 11;: Authors: Chen G, Yu C, Tang Z, Liu S, An F, Zhu J, Wu Q, Cao J, Zhan Q, Zhang S Abstract Gastric cancer is one of the most common malignant tumor types worldwide, with a high morbidity and associated mortality. The interaction between gastric cancer cells and their microenvironment has a significant role in their maintenance and progression. Gastric tumor‑associated fibroblasts (TAFs) are among the major regulators of the gastric cancer microe...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of cyclooxygenase ‑1 stimulates mitochondrial apoptosis through the NF‑κB signaling pathway in colorectal cancer cells.
Downregulation of cyclooxygenase‑1 stimulates mitochondrial apoptosis through the NF‑κB signaling pathway in colorectal cancer cells. Oncol Rep. 2018 Oct 12;: Authors: Ding L, Gu H, Lan Z, Lei Q, Wang W, Ruan J, Yu M, Lin J, Cui Q Abstract The prognosis of patients with colorectal cancer (CRC) remains poor owing to diagnosis typically occurring at advanced stages of the disease. The understanding of the molecular regulatory signatures of CRC may lead to the identification of biomarkers for the early detection, prevention and clinical intervention of CRC. Epidemiological studies have indicated...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

High expression of TMEM40 contributes to progressive features of tongue squamous cell carcinoma.
This study aimed to investigate the expression and clinical significance of TMEM40 in TSCC and its roles in TSCC cells. Immunohistochemical analysis was performed to detect the expression levels of TMEM40 in 60 tongue tissue samples. Furthermore, TMEM40 was overexpressed and inhibited in two TSCC cell lines by transfection with pEZ‑M98‑TMEM40 plasmid or TMEM40 small interfering RNA, respectively. Cell Counting Kit‑8 and colony formation assays were used to investigate the effects of TMEM40 on cell proliferation and colony formation ability, respectively. Flow cytometry was performed to determine cell apoptosis and cy...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Licochalcone  H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3.
Licochalcone H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3. Oncol Rep. 2018 Oct 11;: Authors: Nho SH, Yoon G, Seo JH, Oh HN, Cho SS, Kim H, Choi HW, Shim JH, Chae JI Abstract Licochalcone H (LCH) is a chemical compound that is a positional isomer of licochalcone C (LCC), a chalconoid isolated from the root of Glycyrrhiza inflata, which has various pharmacological properties including anti‑inflammatory, antioxidant, antitumor, and anticancer effects. However, the efficacy of LCH on cancer cells has not been investigated. The present ...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF ‑7 and MDA-MB-231 breast carcinoma cells.
Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. Oncol Rep. 2018 Oct 12;: Authors: Schröder L, Marahrens P, Koch JG, Heidegger H, Vilsmeier T, Phan-Brehm T, Hofmann S, Mahner S, Jeschke U, Richter DU Abstract We investigated the anticarcinogenic potential of green tea and its components epigallocatechin gallate (EGCG) and quercetin, as well as tamoxifen, on MCF-7 and MDA-MB-23 breast cancer cells. Using high-performance liquid chromatography, the quantity of EGCG and quercetin in green tea was analyzed. T...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The diagnostic value of circulating microRNAs as a biomarker for gastric cancer: A meta ‑analysis.
The diagnostic value of circulating microRNAs as a biomarker for gastric cancer: A meta‑analysis. Oncol Rep. 2018 Oct 11;: Authors: Wei H, Pu K, Liu XG, Li BX, Zhang HS, Wang H, Wang H, Sun WM, Wang YP Abstract Recently, cancer research microRNA studies have drawn great attention. However, the results of these studies have been inconsistent and variable regarding the availability of circulating miRNAs in gastric cancer (GC) diagnosis. Thus, results should be interpreted cautiously. The purpose of the present study was to assess the diagnostic performance of circulating miRNAs in GC diagnosis. We cond...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia ‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation.
Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation. Oncol Rep. 2018 Oct 12;: Authors: Valencia-Cervantes J, Huerta-Yepez S, Aquino-Jarquín G, Rodríguez-Enríquez S, Martínez-Fong D, Arias-Montaño JA, Dávila-Borja VM Abstract Medulloblastomas are among the most frequently diagnosed pediatric solid tumors, and drug resistance remains as the principal cause of treatment failure. Hypoxia and the subsequent...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

GLIS2 redundancy causes chemoresistance and poor prognosis of gastric cancer based on co ‑expression network analysis.
GLIS2 redundancy causes chemoresistance and poor prognosis of gastric cancer based on co‑expression network analysis. Oncol Rep. 2018 Oct 15;: Authors: Yuan J, Tan L, Yin Z, Tao K, Wang G, Shi W, Gao J Abstract Gastric cancer is currently the fourth most common cancer and the third leading cause of cancer‑associated mortality worldwide. Studies have identified that certain biomarkers contribute to the prognosis, diagnosis and treatment of gastric cancer. However, the biomarkers of gastric cancer are rarely used clinically. Therefore, it is imperative to define novel molecular networks and key genes...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Targeting LRH ‑1 in hepatoblastoma cell lines causes decreased proliferation.
Targeting LRH‑1 in hepatoblastoma cell lines causes decreased proliferation. Oncol Rep. 2018 Oct 15;: Authors: Jin J, Jin J, Woodfield SE, Patel RH, Jin NG, Shi Y, Liu B, Sun W, Chen X, Yu Y, Vasudevan SA Abstract Hepatoblastoma is the most common malignant liver tumor in children. Since it is often unresectable and exhibits drug resistance, the treatment of advanced hepatoblastoma is challenging. The orphan nuclear receptor liver receptor homolog‑1 (LRH‑1) serves prominent roles in malignancy; however, to the best of our knowledge, the role of LRH‑1 in hepatoblastoma remains unknown. In the pr...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Affibody ‑mediated imaging of EGFR expression in prostate cancer using radiocobalt‑labeled DOTA‑ZEGFR:2377.
In conclusion, the present study demonstrated the feasibility of using the radiocobalt labeled anti‑EGFR affibody conjugate ZEGFR:2377 as an imaging agent for in vivo visualization of low EGFR‑expressing tumors, like PCa, and for monitoring of receptor occupancy during cetuximab therapy as well as the importance of optimal dosing in order to achieve higher sensitivity molecular imaging. PMID: 30320363 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibitory effects of Schisandrin  B on human prostate cancer cells.
Inhibitory effects of Schisandrin B on human prostate cancer cells. Oncol Rep. 2018 Oct 15;: Authors: Nasser MI, Han T, Adlat S, Tian Y, Jiang N Abstract Prostate cancer is a serious affliction worldwide. Although much progress has been made in the study of prostate cancer prevention and treatment, less attention has been paid to the molecular mechanism of the disease. The molecular arrangement by which Schisandrin B (Sch B) induces human prostate cancer cytotoxicity was comprehensively examined in the present study. As indicated by the results of flow cytometric and western blot analysi...
Source: Oncology Reports - October 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research