Synergistic effect of arsenic trioxide, vismodegib and temozolomide on glioblastoma.
Authors: Bureta C, Saitoh Y, Tokumoto H, Sasaki H, Maeda S, Nagano S, Komiya S, Taniguchi N, Setoguchi T Abstract The treatment of glioblastoma is a critical health issue, owing to its resistance to chemotherapy. The current standard of treatment is surgical resection, followed by adjuvant radiotherapy and temozolomide treatment. Long‑term local treatment of glioblastoma is rarely achieved and the majority of the patients undergo relapse. Resistance to temozolomide emerges from numerous signalling pathways that are altered in glioblastoma, including the Hedgehog signalling pathway. Hence, further research is requ...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

JS ‑K induces G2/M phase cell cycle arrest and apoptosis in A549 and H460 cells via the p53/p21WAF1/CIP1 and p27KIP1 pathways.
JS‑K induces G2/M phase cell cycle arrest and apoptosis in A549 and H460 cells via the p53/p21WAF1/CIP1 and p27KIP1 pathways. Oncol Rep. 2019 Apr 09;: Authors: Song Z, Yin Y, Hao S, Wei J, Liu B, Huang X, Gao C, Zhu R, Liao W, Cai Abstract Lung cancer is one of the most common malignancies worldwide, with high mortality and morbidity rates. O2‑​(2,4‑​dinitrophenyl)‑1‑​[(4‑ethoxycarbonyl)piperazin‑1‑yl]diazen‑1‑ium‑1,2‑diolate (JS‑K) is a potent anticancer agent that acts against a subset of human non‑small cell lung cancer (NSCLC) cell lines; however, the underlying me...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect of electrochemotherapy with betulinic acid or cisplatin on regulation of heat shock proteins in metastatic human carcinoma cells in  vitro.
Effect of electrochemotherapy with betulinic acid or cisplatin on regulation of heat shock proteins in metastatic human carcinoma cells in vitro. Oncol Rep. 2019 Apr 08;: Authors: Mączyńska J, Choromańska A, Kutkowska J, Kotulska M, Zalewski M, Zalewski J, Kulbacka J, Saczko J Abstract Betulinic acid (BTA) is naturally occurring triterpene that has received interest as a novel therapeutic substance with cytotoxicity towards a number of cancer cell lines. Despite the wide spectrum of biological and pharmacological effects, its effect may be limited its lipophobic properties. Therefore, strategie...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Metformin suppresses hypoxia ‑induced migration via the HIF‑1α/VEGF pathway in gallbladder cancer in vitro and in vivo.
[Corrigendum] Metformin suppresses hypoxia‑induced migration via the HIF‑1α/VEGF pathway in gallbladder cancer in vitro and in vivo. Oncol Rep. 2019 Apr 05;: Authors: Ye J, Chen K, Qi L, Li R, Tang H, Zhou C, Zhai W Abstract The authors have noted that the address given for the Affiliated Hospital of Zhengzhou University in the above article was presented incorrectly: This should have been written as the First Affiliated Hospital of Zhengzhou University. Therefore, the author affiliations for this paper should have appeared as follows: Jianwen Ye1,2, Kunlun Chen1,2, Lei Qi3, Renfeng...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Pomolic acid exhibits anticancer potential against a docetaxel ‑resistant PC3 prostate cell line.
We examined the effects of pentacyclic triterpene pomolic acid (PA) on docetaxel‑resistant PC3 cells. Cell viability was evaluated using the MTT assay. Apoptosis was evaluated by cell cycle analysis using flow cytometry. The activity of multiple drug resistance (MDR) proteins was determined by the accumulation of specific substrates [mitoxantrone, rhodamine 123 and 5‑carboxyfluorescein diacetate (CFDA)]. The evaluation of epithelial to mesenchymal transition (EMT) proteins was conducted by immunocytochemical assays. It was demonstrated that PC3R cells presents multidrug resistance and EMT phenotype and express active P...
Source: Oncology Reports - April 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Microwave hyperthermia enhances the sensitivity of lung cancer cells to gemcitabine through reactive oxygen species ‑induced autophagic death.
Microwave hyperthermia enhances the sensitivity of lung cancer cells to gemcitabine through reactive oxygen species‑induced autophagic death. Oncol Rep. 2019 Mar 22;: Authors: Yang Y, Yang CL, Zhao ZJ, Zuo XX, Liang TS, Yang Y, Ma SL, Yang DK Abstract The pleiotropic effects of hyperthermia on cancer cells have been well documented, and microwave hyperthermia (MWHT) has been widely applied for multifarious cancer treatment. However, the mechanisms underlying the anticancer effect of MWHT combined with gemcitabine (GEM) remain poorly understood. The aim of the present study was to investigate the role...
Source: Oncology Reports - April 13, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Predictive value of the ratio of 8 ‑hydroxydeoxyguanosine levels between cancerous and normal tissues in patients with stage II/III colorectal cancer.
Predictive value of the ratio of 8‑hydroxydeoxyguanosine levels between cancerous and normal tissues in patients with stage II/III colorectal cancer. Oncol Rep. 2019 May;41(5):3041-3050 Authors: Kitagawa H, Kitajima Y, Kai K, Komukai S, Tanaka T, Koga Y, Manabe T, Noshirο H Abstract Reactive oxygen species (ROS) accumulation is known to induce carcinogenesis and accelerate cancer progression. 8‑Hydroxydeoxyguanosine (8‑OHdG) is a specific marker of ROS‑mediated DNA damage. Therefore, we analysed 8‑OHdG levels in cancerous and normal tissue DNA via enzyme‑linked immunosorbent assay (...
Source: Oncology Reports - April 11, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TRPC5 ‑induced autophagy promotes the TMZ‑resistance of glioma cells via the CAMMKβ/AMPKα/mTOR pathway.
TRPC5‑induced autophagy promotes the TMZ‑resistance of glioma cells via the CAMMKβ/AMPKα/mTOR pathway. Oncol Rep. 2019 Apr 02;: Authors: Zou Y, Chen M, Zhang S, Miao Z, Wang J, Lu X, Zhao X Abstract Temozolomide (TMZ) is the first choice chemotherapy agent against glioblastoma, but the TMZ chemotherapy resistance has restricted the clinical application. Although autophagy is considered an adaptive response for cell survival under the pressure of chemotherapy and associated with chemotherapy resistance, its initiator and the precise molecular mechanism remains unknown. In the present stud...
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Combination of SB431542, CHIR99021 and PD0325901 has a synergic effect on abrogating valproic acid ‑induced epithelial‑mesenchymal transition and stemness in HeLa, 5637 and SCC‑15 cells.
Combination of SB431542, CHIR99021 and PD0325901 has a synergic effect on abrogating valproic acid‑induced epithelial‑mesenchymal transition and stemness in HeLa, 5637 and SCC‑15 cells. Oncol Rep. 2019 Apr 01;: Authors: Zhang Y, Zhang Y, Li M, Meng F, Yu Z, Chen Y, Cui G Abstract Epithelial‑mesenchymal transition (EMT) plays an important role in cancer progression, metastasis and drug resistance, and recent studies have revealed that neoplastic epithelial cells regain the stem cell state through EMT. Single‑agent targeted cancer therapy frequently fails due to acquired drug resistance. Theref...
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Retracted] Serum ‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2.
[Retracted] Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2. Oncol Rep. 2019 Mar 29;: Authors: Wu J, Shang AQ, Chen C, Wang WW, Xiong CQ, Guo NZ Abstract The authors wish to retract their research article entitled 'Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2', published in Oncology Reports 40, 3033‑3039, 2018. After the publication of this article, the auth...
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Prodigiosin isolated from Serratia  marcescens in the Periplaneta americana gut and its apoptosis‑inducing activity in HeLa cells.
Prodigiosin isolated from Serratia marcescens in the Periplaneta americana gut and its apoptosis‑inducing activity in HeLa cells. Oncol Rep. 2019 Apr 02;: Authors: Lin PB, Shen J, Ou PY, Liu LY, Chen ZY, Chu FJ, Wang J, Jin XB Abstract Serratia marcescens are considered to be abundant and optimal resources for obtaining prodigiosin, which can be isolated from soil, water, plants and air but rarely from insects. In the present study, a strain of Serratia marcescens named WA12‑1‑18 was isolated from the gut of Periplaneta americana, which was capable of producing high level...
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

WYE-354 restores Adriamycin sensitivity in multidrug-resistant acute myeloid leukemia cell lines.
Authors: Ibrahim SM, Bakhashab S, Ilyas AM, Pushparaj PN, Karim S, Khan JA, Abuzenadah AM, Chaudhary AG, Al-Qahtani MH, Ahmed F Abstract Multidrug resistance (MDR) is a major reason for the failure of acute myeloid leukemia (AML) therapy. Agents that reverse MDR and sensitize AML cells to chemotherapy are of great clinical significance. The present study developed Adriamycin (Adr)‑resistant cell lines, namely K562/Adr200 and K562/Adr500, which exhibited MDR. The upregulation of ATP‑binding cassette subfamily B member 1 (ABCB1) was confirmed as the mechanism of resistance by reverse transcrip...
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Optimal subset of signature miRNAs consisting of 7  miRNAs that can serve as a novel diagnostic and prognostic predictor for the progression of cervical cancer.
In conclusion, the subset of signature miRNAs could potentially serve as a novel diagnostic and prognostic predictor for cervical cancer. PMID: 30942460 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Isobavachalcone exerts anti ‑proliferative and pro‑apoptotic effects on human liver cancer cells by targeting the ERKs/RSK2 signaling pathway.
Isobavachalcone exerts anti‑proliferative and pro‑apoptotic effects on human liver cancer cells by targeting the ERKs/RSK2 signaling pathway. Oncol Rep. 2019 Apr 02;: Authors: Li B, Xu N, Wan Z, Ma L, Li H, Cai W, Chen X, Huang Z, He Z Abstract Aberrant activation of the extracellular signal‑regulated kinases (ERKs)/ribosomal S6 kinase 2 (RSK2) signaling pathway is frequently determined in various human tumor types, including liver cancer, and has been considered as a promising target for cancer chemoprevention and therapy. In the present study, using computer‑aided virtual screening and m...
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Gene profiling of HepG2 cells following nitidine chloride treatment: An investigation with microarray and Connectivity Mapping.
Authors: Liu LM, Lin P, Yang H, Dang YW, Chen G Abstract Nitidine chloride (NC), an inartificial bioactive alkaloid present in the root of Zanthoxylum nitidum (Roxb.) DC, is known for its versatile anti‑inflammation and anticancer capabilities. The molecular mechanisms underlying its anticancer properties, however, remain obscure. The authors of the present study demonstrated the tumor suppressive effects of NC in a human liver cancer cell line using an MTT assay. The tumor suppressive capacity of NC was also analysed in a tumor xenograft nude mouse model. Changes in tumor cell gene expression profiles follo...
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of dysregulated microRNAs associated with diagnosis and prognosis in triple ‑negative breast cancer: An in silico study.
In conclusion, the results in the present study may highlight efficient biomarkers for the diagnosis of TNBC and its prognosis. In‑depth exploitation of these miRNAs will help define and develop novel molecular therapeutic strategies and improve prognosis for TNBC patients. PMID: 30942465 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TRAIP regulates Histone  H2B monoubiquitination in DNA damage response pathways.
TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways. Oncol Rep. 2019 Apr 02;: Authors: Han YG, Yun M, Choi M, Lee SG, Kim H Abstract Histone H2B monoubiquitination has been shown to play critical roles in diverse cellular processes including DNA damage response. Although recent data indicate that H2B monoubiquitination is strongly connected with tumor progression and regulation, the implications of this modification in lung adenocarcinoma are relatively unknown. In the present study, we demonstrated the clinical implication of H2B monoubiquitination and the potential rol...
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effect and changes in PD ‑1 expression of CD19 CAR‑T cells from T cells highly expressing PD‑1 combined with reduced‑dose PD‑1 inhibitor.
In conclusion, a reduced dose of a PD‑1 inhibitor combined with CD19 CAR‑T cells appears to be a promising treatment option for relapsed/refractory B‑NHL exhibiting high PD‑1 expression by T cells. This method may achieve good clinical efficacy while reducing the side-effects of PD‑1 inhibitors. PMID: 30942469 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LASS2 inhibits proliferation and induces apoptosis in HepG2 cells by affecting mitochondrial dynamics, the cell cycle and the nuclear factor ‑κB pathways.
LASS2 inhibits proliferation and induces apoptosis in HepG2 cells by affecting mitochondrial dynamics, the cell cycle and the nuclear factor‑κB pathways. Oncol Rep. 2019 Mar 13;: Authors: Yang Y, Yang X, Li L, Yang G, Ouyang X, Xiang J, Zhang T, Min X Abstract LAG1 longevity assurance homolog 2 (LASS2) is a candidate biomarker in cancer that is dysregulated in various types of tumor, potentially affecting cell growth, invasion and migration. Although its effects on liver cancer metastasis and invasion have been reported, specific phenotypic studies and potential molecular mechanisms have not be...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Role of natural killer cells for immunotherapy in chronic myeloid leukemia (Review).
Authors: Lee HR, Baek KH Abstract The majority of natural killer (NK) cells serve an important role in eliminating malignant cells. The cytotoxic effects of NK cells were first identified against leukemia cells, and it is now hypothesized that they may have a critical role in leukemia therapy. The cellular functions of NK cells are mediated by their cell surface receptors, which recognize ligands on cancer cells. The role of NK cells is specifically regulated by the activating or inhibitory killer cell immunoglobulin‑like receptors (KIRs) on their surface, which bind to the human leukocyte antigen (HLA) class I l...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Diagnostic and prognostic value of mRNA expression of phospholipase C β family genes in hepatitis B virus‑associated hepatocellular carcinoma.
Diagnostic and prognostic value of mRNA expression of phospholipase C β family genes in hepatitis B virus‑associated hepatocellular carcinoma. Oncol Rep. 2019 Mar 14;: Authors: Wang X, Huang K, Zeng X, Liu Z, Liao X, Yang C, Yu T, Han C, Zhu G, Qin W, Peng T Abstract Four phospholipase C β (PLCB) isoforms, PLCB1, PLCB2, PLCB3 and PLCB4, have been previously investigated regarding their roles in the metabolism of inositol lipids and cancer. The present study aimed to explore the association between PLCB1‑4 and hepatocellular carcinoma (HCC). Data from 212 patients with hepatitis B virus‑...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hepatitis  C virus nonstructural 5A protein inhibits the starvation‑induced apoptosis of hepatoblastoma cells by increasing Beclin 1 expression.
Hepatitis C virus nonstructural 5A protein inhibits the starvation‑induced apoptosis of hepatoblastoma cells by increasing Beclin 1 expression. Oncol Rep. 2019 Mar 13;: Authors: Quan M, Liu S, Zhou L, Feng S, Zhang Y, Cheng J Abstract Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) modulates cellular apoptosis, which is involved in the occurrence and development of liver cancer. The mechanisms of apoptosis inhibition by NS5A in liver cancer cells remains unclear. Beclin 1, which functions upstream of autophagosome formation, is upregulated by NS5A. Autophagy, an evolutionarily ...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Timosaponin  A‑III induces autophagy of T‑cell acute lymphoblastic leukemia Jurkat cells via inhibition of the PI3K/Akt/mTOR pathway.
Timosaponin A‑III induces autophagy of T‑cell acute lymphoblastic leukemia Jurkat cells via inhibition of the PI3K/Akt/mTOR pathway. Oncol Rep. 2019 Mar 15;: Authors: Wang H, Dong R, Fan WW, Zheng XC, Li AM, Wang WD Abstract Timosaponin A‑III (TAIII) is a saponin isolated from anemarrhena asphodeloides and possesses the inhibitory effect on proliferation of multiple tumor cells. In the present study, the antitumor effect of TAIII and its underlying molecular mechanisms were investigated in vitro in T‑cell acute lymphoblastic leukemia (T‑ALL) Jurkat cells. The results demonstrat...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The PI3K inhibitor buparlisib suppresses osteoclast formation and tumour cell growth in bone metastasis of lung cancer, as evidenced by multimodality molecular imaging.
Authors: Wang S, Niu X, Bao X, Wang Q, Zhang J, Lu S, Wang Y, Xu L, Wang M, Zhang J Abstract Non‑small cell lung cancer (NSCLC) metastasis commonly occurs in bone, which often results in pathological fractures. Sustained phosphoinositide‑3‑kinase (PI3K) signalling promotes the growth of PI3K‑dependent NSCLC and elevates osteoclastogenic potential. The present study investigated the effects of a PI3K inhibitor on NSCLC growth in bone and osteoclast formation, and aimed to determine whether it could control symptoms associated with bone metastasis. A bone metastasis xenograft model was established by implanti...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl ‑2/Bax and GSK3β/β‑catenin signaling pathways.
In conclusion, songorine exerted its anticancer effect through the GSK3β/β‑catenin and Bcl‑2/Bax signaling pathways. These results highlight the potential use of songorine as a novel therapeutic agent for EOC. PMID: 30896826 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Survivin overexpression in head and neck squamous cell carcinomas as a new therapeutic target (Review).
Authors: Frassanito MA, Saltarella I, Vinella A, Muzio LL, Pannone G, Fumarulo R, Vacca A, Mariggiò MA Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. It has poor clinical outcome due to intrinsic or acquired drug resistance. Deregulation of both apoptosis and autophagy contributes to chemotherapy resistance and disease progression. A new member of the inhibitors of apoptosis protein (IAP) family, namely survivin, is selectively overexpressed in tumors, including HNSCC, but not in normal tissues. Thus, it is considered a tumor biomarker. Here, we ...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genome-scale integrated analysis to identify prospective molecular mechanisms and therapeutic targets in isocitrate dehydrogenase 2 R140Q-mutated acute myeloid leukemia.
In conclusion, we identified several co-expressing genes and potential molecular mechanisms that are instrumental in IDH2 R140Q-mutated adult de novo AML, along with 13 candidate targeted therapeutic drugs. PMID: 30896832 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription.
Authors: Tanaka S, Honda Y, Takaku S, Koike T, Oe S, Hirahara Y, Yoshida T, Takizawa N, Takamori Y, Kurokawa K, Kodama T, Yamada H Abstract The hypocretin/orexin neuropeptide system coordinates the regulation of various physiological processes. Our previous study reported that a reduction in the expression of pleomorphic adenoma gene‑like 1 (Plagl1), which encodes a C2H2 zinc‑finger transcription factor, occurs in hypocretin neuron‑ablated transgenic mice, suggesting that PLAGL1 is co‑expressed in hypocretin neurons and regulates hypocretin transcription. The present study examined whether canonical prepro...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Higher tumor mass and lower adipose mass are associated with colon ‑26 adenocarcinoma‑induced cachexia in male, female and ovariectomized mice.
Higher tumor mass and lower adipose mass are associated with colon‑26 adenocarcinoma‑induced cachexia in male, female and ovariectomized mice. Oncol Rep. 2019 Mar 20;: Authors: Banh T, Snoke D, Cole RM, Angelotti A, Schnell PM, Belury MA Abstract Cachexia is responsible for nearly 20% of all cancer‑related deaths, yet effective therapies to prevent or treat the disease are lacking. Clinical studies have shown that male patients lose weight at a faster rate than females. Additionally, an 'obesity paradox' may exist where excess adiposity may confer survival to patients with cancer cachexia. To fur...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Construction of ceRNA networks reveals differences between distal and proximal colon cancers.
Authors: Qian W, Feng Y, Li J, Peng W, Gu Q, Zhang Z, Ji D, Wang Q, Zhang D, Sun Y Abstract Although colon cancer is often referred to as a homogeneous entity, an increasing number of studies have revealed that colon cancer can be divided according to the anatomic site of the cancer. However, few studies have reported the difference between distal and proximal colon cancer with regard to molecular mechanism, and especially non‑coding RNA molecules. In the present study, the data of 186 colon tumour tissues and 17 adjacent non‑tumour colon tissues in the left colon and 229 colon tumour tissues and 21 adjacent no...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Selected nitrostyrene compounds demonstrate potent activity in chronic lymphocytic leukaemia cells, including those with poor prognostic markers.
Authors: Bright SA, Byrne AJ, Vandenberghe E, Browne PV, Mcelligott AM, Meegan MJ, Williams DC Abstract The nitrostyrene scaffold was previously identified as a lead target structure for the development of effective compounds targeting Burkitt's lymphoma. The present study aimed to develop these compounds further in haematological malignancies, including chronic lymphocytic leukaemia (CLL). Cellular viability, flow cytometry and lactate dehydrogenase assays, amongst others, were used to examine the effects of nitrostyrene compounds on CLL cells, including a cell line representing disease with poor prognosis (HG‑3...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Astragaloside  IV inhibits the invasion and metastasis of SiHa cervical cancer cells via the TGF‑β1‑mediated PI3K and MAPK pathways.
Astragaloside IV inhibits the invasion and metastasis of SiHa cervical cancer cells via the TGF‑β1‑mediated PI3K and MAPK pathways. Oncol Rep. 2019 Mar 13;: Authors: Zhang L, Zhou J, Qin X, Huang H, Nie C Abstract Astragaloside IV is the main ingredient of the medicinal herb Radix astragali, which has reported to have antitumor activity in vitro and in vivo. To determine whether the inhibitory effect of astragaloside IV on the invasion and metastasis of the cervical cancer cells is associated with epithelial‑mesenchymal transition (EMT), wound healing and Transwell assays were performed...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Antitumor effects of hsa ‑miR661‑3p on non‑small cell lung cancer in vivo and in vitro.
Antitumor effects of hsa‑miR661‑3p on non‑small cell lung cancer in vivo and in vitro. Oncol Rep. 2019 Mar 21;: Authors: Lu J, Gu X, Liu F, Rui Z, Liu M, Zhao L Abstract Lung cancer is the most common and lethal cancer worldwide, especially in developing countries. Non‑small cell lung cancer (NSCLC) accounts for 85% of all cases of lung cancer. In aprevious study, the protein expression of ubiquitin conjugating enzyme E2 C (UBE2C/UbcH10) in NSCLC tissues and cells was found to be significantly higher than that in adjacent tissues and normal lung epithelial cells. Further study revealed that the...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Preservation of fertility in patients with cancer (Review).
Authors: Del-Pozo-Lérida S, Salvador C, Martínez-Soler F, Tortosa A, Perucho M, Giménez-Bonafé P Abstract Survival rates in oncological patients have been steadily increasing in recent years due to the greater effectiveness of novel oncological treatments, such as radio‑ and chemotherapy. However, these treatments impair the reproductive ability of patients, and may cause premature ovarian failure in females and azoospermia in males. Fertility preservation in both female and male oncological patients is nowadays possible and should be integrated as part of the oncological healthcare. T...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

microRNA ‑485 inhibits the malignant behaviors of retinoblastoma by directly targeting Wnt3a.
microRNA‑485 inhibits the malignant behaviors of retinoblastoma by directly targeting Wnt3a. Oncol Rep. 2019 Mar 13;: Authors: Lyu X, Wang L, Lu J, Zhang H, Wang L Abstract Deregulation of microRNAs (miRNAs) has been widely reported in retinoblastoma (RB), and the aberrantly expressed miRNAs may serve as crucial epigenetic regulators in the occurrence and development of RB. Therefore, the identification of dysregulated miRNAs in RB may be useful for the development of effective targets for the therapy patients with this disease. miRNA (miR)‑485‑5p (miR‑485) is deregulated in multiple human canc...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma.
Authors: Guo C, Liang C, Yang J, Hu H, Fan B, Liu X Abstract As a core kinase in the Hippo pathway, large tumor suppressor kinase 2 (LATS2) regulates cell proliferation, migration and invasion through numerous signaling pathways. However, its functions on cell proliferation, migration and invasion in glioma have yet to be elucidated. The present study revealed that LATS2 was downregulated in glioma tissues and cells, as determined by reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry. In addition, Cell Counting Kit‑8, scratch wound healing and Transwell assays revealed that ov...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

5 ‑Azacytidine treatment results in nuclear exclusion of DNA methyltransferase‑1, as well as reduced proliferation and invasion in human cytomegalovirus‑infected glioblastoma cells.
5‑Azacytidine treatment results in nuclear exclusion of DNA methyltransferase‑1, as well as reduced proliferation and invasion in human cytomegalovirus‑infected glioblastoma cells. Oncol Rep. 2019 Mar 18;: Authors: Estekizadeh A, Landázuri N, Pantalone MR, Davoudi B, Hu LF, Nawaz I, Stragliotto G, Ekström TJ, Rahbar A Abstract Glioblastoma (GBM) is the most aggressive form of brain tumor in adults, with a devastating outcome. Emerging evidence shows that human cytomegalovirus (HCMV) proteins and nucleic acids are present in GBM tissues. DNA methylation is important for the initiation ...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hyperbaric oxygen increases glioma cell sensitivity to antitumor treatment with a novel isothiourea derivative in  vitro.
In conclusion, the combination of isothiourea derivatives and hyperbaric oxygenation appears to be a promising therapeutic approach for malignant glioma treatment. PMID: 30896865 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer.
Authors: Cheng Z, Shao X, Xu M, Wang J, Kuai X, Zhang L, Wu J, Zhou C, Mao J Abstract Colorectal carcinoma (CRC) is one of the most common malignancies worldwide and the second leading cause of cancer‑related deaths in the US. Recently, Rab1A has been reported to be an activator of mTORC1 and p‑S6K1, which is downstream of mTORC1. However, the association between Rab1A and p‑S6K1 in CRC remains elusive. In the present study, we first demonstrated that Rab1A was overexpressed in CRC tissues and Rab1A overexpression was positively related to lymph node invasion, degree of differentiation, venous invasion and tu...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] miR-9 regulates the multidrug resistance of chronic myelogenous leukemia by targeting ABCB1.
Authors: Li Y, Zhao L, Li N, Miao Y, Zhou H, Jia L Abstract Following the publication of this article, the authors have subsequently realized that Fig. 2D (lower middle panel, K562‑control group treated with paclitaxel) contained the same data as the left lower panel (K562 group). The authors have examined their original data, and realize that the same data was inadvertently included in this Figure twice. Consequently, the corrected version of Fig. 2, featuring the correct data for the lower middle panel (K562‑control group treated with paclitaxel), is shown opposite. The overall conclusions of this s...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR-363 acts as a tumor suppressor in osteosarcoma cells by inhibiting PDZD2.
Authors: He F, Fang L, Yin Q Abstract PDZ domain containing 2 (PDZD2) is a multi-PDZ domain protein that promotes the proliferation of insulinoma cells, and is upregulated during prostate tumorigenesis. However, the function of PDZD2 in other cancers, including osteosarcoma (OS), remains unclear. Dysregulation of microRNAs (miRNAs) contributes to tumor initiation, proliferation and metastasis, via the regulation of their target genes. The present study investigated the functions of miR-363 and PDZD2 in MG-63 OS cells. The results revealed that MG-63 cells contained low levels of miR-363, and that overexpression of ...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Metabolic dependence of cyclosporine  A on cell proliferation of human non‑small cell lung cancer A549 cells and its implication in post‑transplant malignancy.
Metabolic dependence of cyclosporine A on cell proliferation of human non‑small cell lung cancer A549 cells and its implication in post‑transplant malignancy. Oncol Rep. 2019 Mar 18;: Authors: Qin X, Chen Z Abstract Cyclosporine A (CsA), a widely used immunosuppressant to prevent organ transplant rejection, is associated with an increased cancer risk following transplantation, particularly in the lung. However, the underlying mechanisms remain unclear. In the present study, using human non‑small cell lung cancer A549 cells, it was determined that CsA (0.1 or 1 µM) promoted ce...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Recombinant adenoviruses expressing apoptin suppress the growth of MCF ‑7 breast cancer cells and affect cell autophagy.
In conclusion, apoptin‑induced cell death may involve both autophagy and apoptosis. The induction of autophagy may inhibit apoptosis, whereas apoptosis may inhibit autophagy; however, occasionally both pathways operate at the same time and involve apoptin. This apoptin‑associated selection between tumor cell survival and death may provide a potential therapeutic strategy for breast cancer. PMID: 30896879 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Targeting P16INK4A in uterine serous carcinoma through inhibition of histone demethylation.
Authors: Xiao Z, He Y, Liu C, Xiang L, Yi J, Wang M, Shen T, Shen L, Xue Y, Shi H, Liu P Abstract Uterine serous carcinoma (USC) is a subtype of endometrial cancer. Compared with endometrial endometroid carcinoma, the majority of USC cases are more aggressive. Cyclin-dependent kinase inhibitor 2A (P16INK4A) is a canonical tumor suppressor that blocks cell cycle progression; however, P16INK4A is overexpressed in USC. The aim of the present study was to determine the role of P16INK4A in P16INK4A‑positive endometrial cancer, with the hope of elucidating a novel therapeutic approach for this type of malignancy. A tot...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of cytokeratin 18 enhances BCRP-mediated multidrug resistance through induction of epithelial-mesenchymal transition and predicts poor prognosis in breast cancer.
Authors: Shi R, Wang C, Fu N, Liu L, Zhu D, Wei Z, Zhang H, Xing J, Wang Y Abstract Multiple drug resistance (MDR) and metastasis have been identified as the two major causes of the poor prognosis of patients with breast cancer. However, the relationship between MDR and metastasis has not been characterized. Epithelial‑mesenchymal transition (EMT), a process known to promote metastasis in cancer, has been shown to be associated with the MDR phenotype of many tumor types. Reduced cytokeratin 18 (CK18) expression is thought to be one of the hallmarks of EMT, and the role of CK18 in MDR of metastatic breast cancer r...
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Transcriptome ‑wide piRNA profiling in human gastric cancer.
In conclusion, we conclude that piRNAs are abundant in human stomachs and may play important roles in the etiological processes of gastric cancers. PMID: 30896887 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - March 23, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Y ‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer.
Y‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer. Oncol Rep. 2019 Feb 28;: Authors: Nagasu S, Sudo T, Kinugasa T, Yomoda T, Fujiyoshi K, Shigaki T, Akagi Y Abstract Y‑box‑binding protein 1 (YB‑1) is a DNA/RNA‑-binding protein and an important transcription and translation factor in carcinogenesis. However, the biological function and molecular correlation of YB‑1 in colorectal cancer are not fully understood. The aim of the present study was to determine the significance of YB‑1 expression and its biological role in colorectal cancer. Cell prolif...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Proteins of the Wnt signaling pathway as targets for the regulation of CD133+ cancer stem cells in glioblastoma.
This study aimed to analyze the crucial role that proteins of the Wnt signaling pathway play in stem cell proliferation. The identified proteins were analyzed for their association with the Wnt signaling pathway using the international open databases PubMed, Protein Analysis Through Evolutionary Relationships, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and Search Tool for the Retrieval of Interacting Genes/Proteins. An increased expression of 12 proteins associated with the Wnt signaling pathway were identified in GBM CD133+ CSCs, which included catenin β‑1, disheveled associated activator of morphogenes...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3 β/cyclin D1 signaling pathway.
Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway. Oncol Rep. 2019 Mar 05;: Authors: Lin JX, Xie XS, Weng XF, Qiu SL, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Li P, Huang CM, Zheng CH Abstract Cyclin‑dependent kinase 5 regulatory subunit‑​associated protein 3 (CDK5RAP3 or C53) is involved in the development of various types of tumor, and alternative splicing of C53 results in numerous transcription variants that encode different isoforms. The present study aimed to clone human C53 isoform d (IC...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity.
Authors: Li Y, Zhao C, Liu J, Lu Z, Lu M, Gu J, Liu R Abstract Dendritic cells (DCs), as professional antigen‑presenting cells are essential for the initial activation of adaptive antitumor immunity. CD1d is considered to present phospholipid and glycosphingolipid antigens to NKT cells. However, it is currently unknown whether CD1d expression on DCs is capable of enhancing antitumor immunity, particularly T‑cell related immunity. We observed that CD1d was predominantly expressed on DCs in 3LL tumor‑bearing mice, whilst a deficiency of CD1d promoted tumor growth. Notably, CD1d expression on DCs was not only re...
Source: Oncology Reports - March 14, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research