Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin ‑resistant oral cancer CAR cells.
Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells. Oncol Rep. 2018 Jun 27;: Authors: Chen CF, Yang JS, Chen WK, Lu CC, Chiang JH, Chiu HY, Tsai SC, Juan YN, Huang HJ, Way TD Abstract Oral squamous cell carcinoma (OSCC) is a type of cancer with high morbidity and mortality rates worldwide; it also demonstrates chemotherapeutic resistance. Triterpenoid ursolic acid has been shown to exhibit various biological activities and anticancer effects in several preclinical studies. In our previous stu...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in  vitro and in vivo by inhibiting the EphA2/Akt signaling pathway.
Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway. Oncol Rep. 2018 Jun 27;: Authors: Chen M, Hu C, Guo Y, Jiang R, Jiang H, Zhou Y, Fu H, Wu M, Zhang X Abstract Lung adenocarcinoma is the most common metastatic cancer, and is associated with high patient mortality. Therefore, investigation of anti‑metastatic treatments for lung adenocarcinoma is crucial. Ophiopogonin B (OP‑B) is a bioactive component of Radix Ophiopogon Japonicus, which is often used in Chinese traditional medicine to treat pulmonary ...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Metformin suppresses the invasive ability of pancreatic cancer cells by blocking autocrine TGF ‑β1 signaling.
Metformin suppresses the invasive ability of pancreatic cancer cells by blocking autocrine TGF‑β1 signaling. Oncol Rep. 2018 Jun 22;: Authors: Duan W, Qian W, Zhou C, Cao J, Qin T, Xiao Y, Cheng L, Li J, Chen K, Li X, Ma J, Ma Q Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive neoplasm with a 5‑year survival rate of
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor ‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer.
Tumor‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer. Oncol Rep. 2018 Jun 27;: Authors: Ji F, Sha H, Meng F, Zhu A, Ding N, Zhang H, Xu H, Qian H, Yu L, Liu Q, Liu B Abstract Radiotherapy has been the primary method for the local control of several types of unresectable tumor, including gastric cancer. Patients with gastric cancer frequently express high levels of epidermal growth factor receptor (EGFR), which have been found to increase following radiotherapy treatment. This provides a basis for the combination of anti...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53.
In conclusion, our results elucidated the importance of S100B in the maintenance of OCSC chemoresistance, which may provide a promising therapeutic target for ovarian cancer. PMID: 29956807 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells.
Authors: Wang R, Li Y, Chen Y, Wang L, Wu Q, Guo Y, Li Y, Liu J, Wang L Abstract RAD54 homolog B is a central motor protein of homologous recombination (HR), which plays an important role in the development and evolution of human cancer. Recent studies have indicated that RAD54B is aberrantly expressed in a variety of cancers and exhibits numerous biological functions, including participating in the repair of DNA double strand breaks. However, the expression and function of RAD54B in liver cancer have not yet been reported. The aim of the present study was to investigate the expression of RAD54B and elucidate its r...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Adiponectin inhibits migration and invasion by reversing epithelial ‑mesenchymal transition in non‑small cell lung carcinoma.
Adiponectin inhibits migration and invasion by reversing epithelial‑mesenchymal transition in non‑small cell lung carcinoma. Oncol Rep. 2018 Jun 25;: Authors: Cui E, Guo H, Shen M, Yu H, Gu D, Mao W, Wang X Abstract Adiponectin is the most abundant adipokine in the tumor microenvironment. The role of this protein in tumor progression, however, remains controversial. In the present study, we aimed to investigate the effects of adiponectin on the abilities of migration and invasion in non‑small cell lung carcinoma (NSCLC). Using NSCLC cell lines, we examined the effects of adiponectin on cell migra...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer.
In conclusion, sex, BMI and age are associated with the incidence and survival rates for cancers. These results could be used to supplement precision and personalized medicine. PMID: 29956810 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑195‑5p regulates multi‑drug resistance of gastric cancer cells via targeting ZNF139.
In conclusion, miR‑195‑5p regulated the MDR of GC cells via targeting ZNF139. PMID: 29956811 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasion.
Authors: Liu M, Zhang X, Cai J, Li Y, Luo Q, Wu H, Yang Z, Wang L, Chen D Abstract TRIM58 is a member of the tripartite motif protein (TRIM) family of E3 ubiquitin ligases. Aberrant gene methylation of TRIM58 has been reported in liver and lung cancer and indicates a poor patient prognosis. However, the expression level and functional role of TRIM58 in colorectal cancer (CRC) have yet to be elucidated. In the present study, we found that TRIM58 expression was significantly suppressed in human CRC and was inversely correlated with CRC progression. Additionally, overall survival was significantly reduced in patients ...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

E ‑cadherin is downregulated by microenvironmental changes in pancreatic cancer and induces EMT.
E‑cadherin is downregulated by microenvironmental changes in pancreatic cancer and induces EMT. Oncol Rep. 2018 Jun 27;: Authors: Wang W, Dong L, Zhao B, Lu J, Zhao Y Abstract The aim of the present study was to research the effect of microenvironmental change on epithelial‑mesenchymal transition (EMT) in pancreatic cancer cells and to determine the correlation between E‑cadherin expression and the prognosis of pancreatic cancer patients. We established hypoxic, serum‑deficient and TGF‑β‑induced microenvironment models of pancreatic cancer cells and studied the changes in the mRNA and ...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulation of the Kank1 gene inhibits human lung cancer progression in  vitro and in vivo.
Upregulation of the Kank1 gene inhibits human lung cancer progression in vitro and in vivo. Oncol Rep. 2018 Jun 26;: Authors: Gu Y, Zhang M Abstract Kank1, an important member of the Kank gene family, plays an important role in the development of many malignant tumors. As a brand new tumor-suppressor gene, the expression of Kank1 gene has been revealed to be downregulated or absent in many malignant tumors. However, there is no study concerning the specific role of Kank1 in the development and progression of lung cancer. In the present study, we found that the Kankl gene was significantly dow...
Source: Oncology Reports - July 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] Bioinformatics analysis of differentially expressed miRNA ‑related mRNAs and their prognostic value in breast carcinoma.
[Corrigendum] Bioinformatics analysis of differentially expressed miRNA‑related mRNAs and their prognostic value in breast carcinoma. Oncol Rep. 2018 Jun 19;: Authors: Zhang GM, Goyal H, Song LL Abstract Subsequently to the publication of this article, the authors have realized that the first of the affiliations had appeared incorrectly: 'Shying People's Hospital, Shyang Affiliated Hospital of Xuzhou Medical University, Shying' should have appeared as 'Shuyang People's Hopital, Shuyang Affiliated Hospital of Xuzhou Medical University, Shuyang'. The authors regret this error in the affiliations, and a...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Association between methylation of tumor suppressor gene SOCS1 and acute myeloid leukemia.
Authors: Zhang XH, Yang L, Liu XJ, Zhan Y, Pan YX, Wang XZ, Luo JM Abstract Suppressor of cytokine signaling‑1 (SOCS1) is a widely recognized tumor suppressor gene. Silencing of SOCS1 expression as a result of promoter methylation is associated with occurrence and development of solid tumors such as liver, cervical and pancreatic cancer. However, the association between SOCS1 gene methylation and acute myeloid leukemia (AML) has not been well explored. In the present study, we examined whether gene expression and methylation status of SOCS1 was altered in AML, and whether this was related to disease occurrence an...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Aberrantly expressed genes and miRNAs in human hypopharyngeal squamous cell carcinoma based on RNA ‑sequencing analysis.
Aberrantly expressed genes and miRNAs in human hypopharyngeal squamous cell carcinoma based on RNA‑sequencing analysis. Oncol Rep. 2018 Jun 19;: Authors: Li H, Wang F, Fei Y, Lei Y, Lu F, Guo P, Li W, Xun X Abstract The aim of the present study was to investigate the key genes, miRNAs and pathways in hypopharyngeal squamous cell carcinoma (HPSCC) and to elucidate the mechanisms underlying HPSCC development. The gene and microRNA (miRNA) expression profiles of HPSCC tissues and adjacent normal tissues from three subjects were obtained. Differentially expressed genes (DEGs) and differentially expressed...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HBsAg/ β2GPI activates the NF‑κB pathway via the TLR4/MyD88/IκBα axis in hepatocellular carcinoma.
HBsAg/β2GPI activates the NF‑κB pathway via the TLR4/MyD88/IκBα axis in hepatocellular carcinoma. Oncol Rep. 2018 Jun 19;: Authors: Jing X, Tian Z, Gao P, Xiao H, Qi X, Yu Y, Ding X, Yang L, Zong L Abstract Chronic hepatitis B virus (HBV) infection remains one of the leading causes of hepatocellular carcinoma (HCC) globally. However, the mechanism underlying the mediation by HBV surface proteins (HBsAgs) of the early steps in the virus life cycle and following HCC development is unclear. β‑2‑glycoprotein I (β2GPI) specifically interacts with HBsAg and de...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma.
Authors: Sun Y, Jiang F, Pan Y, Chen X, Chen J, Wang Y, Zheng X, Zhang J Abstract X‑box‑binding protein 1 (XBP1) contributes to various types of cancer including breast, bladder cancer and esophageal squamous cell carcinoma. The aim of the study was to examine the metastatic role of XBP1 in oral squamous cell carcinoma (OSCC), and identify possible downstream molecules. Immunohistochemical staining was conducted on tissue microarrays comprising 96 OSCC cases to determine the expression level of XBP1 and analyze its association with metastasis, clinicopathological characteristics and survival prognosis. Compared...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non-coding RNA BANCR regulates cancer stem cell markers in papillary thyroid cancer via the RAF/MEK/ERK signaling pathway.
Authors: Wang Y, Lin X, Fu X, Yan W, Lin F, Kuang P, Luo Y, Lin E, Hong X, Wu G Abstract Thyroid cancer is one of the most common malignant tumors of the endocrine system. Among all thyroid cancers, papillary thyroid carcinoma (PTC) is the most common type. The BRAF-activated non-coding RNA (BANCR) is a 693-bp nucleotide transcript which was first identified in melanoma. However, the role of BANCR in the development of thyroid cancer remains unclear. Therefore, the present study investigated the potential involvement of BANCR in the development of thyroid cancer in vitro using patient tissue samples and a pane...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HGF derived from cancer ‑associated fibroblasts promotes vascularization in gastric cancer via PI3K/AKT and ERK1/2 signaling.
In conclusion, CAF‑derived HGF promotes angiogenesis, VM and mosaic vessel formation via PI3K/AKT and ERK1/2 signaling in gastric cancer and HGF may serve as a potential therapeutic target for cancer anti‑vascular treatment. PMID: 29917165 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP ‑2.
SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP‑2. Oncol Rep. 2018 Jun 18;: Authors: Xu M, Jaing H, Wang H, Liu J, Liu B, Guo Z Abstract The mechanisms of malignant cell metastasis to secondary sites are complex and multifactorial. Studies have demonstrated that small integrin‑binding ligand N‑linked glycoproteins (SIBLINGs), particularly bone sialoprotein (BSP) and osteopontin (OPN), are involved in neoplastic growth and metastasis. SIBLINGs promote malignant cell invasion and metastasis by enhancing matrix metalloproteinase 2 (MMP‑2) and MMP‑9 ex...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Androgen receptor induces EPHA3 expression by interacting with transcription factor SP1.
This study is aimed to investigate the association between EPHA3 expression and androgen receptor (AR) signaling and the potential mechanism. We determined mRNA and protein levels of EPHA3 and AR signaling‑related genes in the PCa cell line 22Rv1 by reverse transcription‑polymerase chain reaction (RT‑PCR) and western blotting, respectively. The EPHA3 mRNA and protein levels were both found to be elevated by dihydrotestosterone (DHT) hormone in a dose‑ and time‑dependent manner, as AR and prostate‑specific antigen (PSA) expression were increased. Similarly, EPHA3 protein levels were also increased in the PCa cel...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues.
Authors: Tamura H, Higa A, Hoshi H, Hiyama G, Takahashi N, Ryufuku M, Morisawa G, Yanagisawa Y, Ito E, Imai JI, Dobashi Y, Katahira K, Soeda S, Watanabe T, Fujimori K, Watanabe S, Takagi M Abstract Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture; however, their use is low-throughput and costly. To overcome this limitation, patient-derived tumor organoids (PDOs) were established from human lung, ovarian and uterine tumor tissues, among others, to accurately and efficiently recapitulate the tissue architecture...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel strategy of EGFR ‑TKI combined chemotherapy in the treatment of human lung cancer with EGFR‑sensitive mutation.
A novel strategy of EGFR‑TKI combined chemotherapy in the treatment of human lung cancer with EGFR‑sensitive mutation. Oncol Rep. 2018 Jun 18;: Authors: Zhang L, Qi Y, Xing K, Qian S, Zhang P, Wu X Abstract The discovery of epidermal growth factor receptor (EGFR)‑sensitive mutations in non‑small cell lung cancer (NSCLC) and the successful clinical application of EGFR tyrosine kinase inhibitors (TKIs) have changed the regimen of lung cancer therapy from traditional cytotoxic chemotherapy to molecular‑targeted cancer therapy. However, the main limitation of EGFR‑TKI therapy is the hetero...
Source: Oncology Reports - June 23, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.
Authors: Gao H, Chen X, Shang Z, Niu Y Abstract Long non-coding RNAs (lncRNAs) make up a significant portion of transcripts that are not translated into proteins and lncRNAs were previously thought to be transcriptional noise. Recently, there has been increased interest in lncRNAs due to their diverse functions in human cancers. At present, lncRNAs are considered to be the main component of the competing endogenous RNA (ceRNA) network due to their regulatory role in protein-coding gene expression by acting as microRNA (miRNA) sponges. However, the function of the lncRNA-mediated ceRNA network in renal cell carcinom...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Timed ‑flat infusion of 5‑fluorouracil with docetaxel and oxaliplatin as first‑line treatment of gastroesophageal adenocarcinoma: A single institution experience with the FD/FOx regimen.
Timed‑flat infusion of 5‑fluorouracil with docetaxel and oxaliplatin as first‑line treatment of gastroesophageal adenocarcinoma: A single institution experience with the FD/FOx regimen. Oncol Rep. 2018 Jun 06;: Authors: Cortellini A, Cannita K, Parisi A, Venditti O, Lanfiuti Baldi P, De Berardis B, Vicentini R, Vicentini V, Verna L, Porzio G, Ficorella C Abstract To date, there is no consensus regarding first‑line chemotherapy for patients with HER2‑negative, locally advanced/metastatic gastric cancer (a/m GC). In the present study we reported a retrospective case‑series of patients treated...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sperm ‑associated antigen 4 (SPAG4) as a new cancer marker interacts with Nesprin3 to regulate cell migration in lung carcinoma.
Sperm‑associated antigen 4 (SPAG4) as a new cancer marker interacts with Nesprin3 to regulate cell migration in lung carcinoma. Oncol Rep. 2018 Jun 04;: Authors: Ji Y, Jiang J, Huang L, Feng W, Zhang Z, Jin L, Xing X Abstract Lung cancer is the most common cause of cancer‑related deaths, and early diagnosis and targeted therapy are extremely important in the treatment of this disease. Sperm‑associated antigen 4 (SPAG4) was recently found to be a novel cancer biomarker. In the present study, the expression of SPAG4 was revealed to be high in lung adenocarcinoma tissues as determined by w...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulated miR ‑20a‑5p expression promotes proliferation and invasion of head and neck squamous cell carcinoma cells by targeting of TNFRSF21.
In conclusion, miR‑20a‑5p functioned as an oncogene in HNSCC by downregulating TNFRSF21 and subsequently, upregulating CCR7 expression. PMID: 29901115 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Genistein and AG1024 synergistically increase the radiosensitivity of prostate cancer cells.
Authors: Tang Q, Ma J, Sun J, Yang L, Yang F, Zhang W, Li R, Wang L, Wang Y, Wang H Abstract Radiosensitivity of prostate cancer (PCa) cells promotes the curative treatment for PCa. The present study was designed to investigate the synergistic effect of genistein and AG1024 on the radiosensitivity of PCa cells. The optimal X‑irradiation dose (4 Gy) and genistein concentration (30 µM) were selected by using the CCK‑8 assay. Before X‑irradiation (4 Gy), PC3 and DU145 cells were treated with genistein (30 µM), AG1024 (10 µM) and their combination. All treatments signifi...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Diagnostic value and lymph node metastasis prediction of a custom ‑made panel (thyroline) in thyroid cancer.
In conclusion, the prediction value of NGS was higher than the US‑based Thyroid Imaging Reporting and Data System (TI‑RADS). NGS is valuable for the accurate differentiation of benign and malignant thyroid nodules, and pathological subtypes in FFPE samples. The findings of the present study may pave the way for the application of NGS in analyzing fine‑needle aspiration (FNA) biopsy samples. PMID: 29901149 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Estrogen ‑related receptor γ promotes the migration and metastasis of endometrial cancer cells by targeting S100A4.
Estrogen‑related receptor γ promotes the migration and metastasis of endometrial cancer cells by targeting S100A4. Oncol Rep. 2018 Jun 04;: Authors: Hua T, Wang X, Chi S, Liu Y, Feng D, Zhao Y, Wang H Abstract S100 calcium binding protein A4 (S100A4) is a well‑established tumor metastasis mediator in various malignancies, including endometrial cancer (EC). However, the regulatory mechanism underlying S100A4 expression remains elusive. In the present study, by analyzing public datasets and clinical samples, we found that estrogen‑related receptor γ (ERRγ) was upregulate...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

G ‑protein‑coupled receptor 120 regulates the development and progression of human esophageal cancer.
In conclusion, we observed an increased level of GPR120 in esophageal cancer tissues, which served as a positive regulator of the development and progression of esophageal cancer. Multiple mechanisms including EMT, PI3K and I‑κB pathway, as well as angiogenesis and inflammation‑related cytokines were involved. PMID: 29901155 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Oct4 promotes cancer cell proliferation and migration and leads to poor prognosis associated with the survivin/STAT3 pathway in hepatocellular carcinoma.
Authors: Wang G, Zhou H, Gu Z, Gao Q, Shen G Abstract Octamer‑binding transcription factor 4 (Oct4) has been identified as a novel transcription factor associated with tumorigenesis, acquisition and maintenance of cancer stem cell characteristics and poor prognosis in tumors. However, the role of Oct4 in tumorigenesis and progression of hepatocellular carcinoma (HCC) has not yet been fully elucidated. In our present study, we observed that the Oct4 expression level was upregulated in HCC specimens as well as in different HCC cell lines. In in vitro experiments, decreased expression of Oct4 by shRNA inhi...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.
In conclusion, Wnt signaling increases DNMT1 expression. DNMT1 contributes to promoter hypermethylation and epigenetic NHERF1 silencing in colon cancer. In addition, we provide novel insight into the mechanisms underlying the regulation of NHERF1 expression and occurrence/progression of colon cancer. PMID: 29901158 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Trop2 is a potential biomarker for the promotion of EMT in human breast cancer.
Authors: Zhao W, Kuai X, Zhou X, Jia L, Wang J, Yang X, Tian Z, Wang X, Lv Q, Wang B, Zhao Y, Huang W Abstract Trop2 is considered to have an important function in tumor metastasis and the promotion of epithelial‑mesenchymal transition (EMT). E‑cadherin is a crucial factor in intercellular adhesion and EMT transformation. In the present study, we detected the expression of Trop2 and E‑cadherin in breast cancer (BC) to better define their prognostic value. The mRNA expression levels of these two genes in 20 cases of fresh BC tissues were detected by quantitative real‑time polymerase chain reaction (qRT...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells.
Authors: Yuan Y, Chiba P, Cai T, Callaghan R, Bai L, Cole SPC, Cai Y Abstract In the present study, a lipid-polymer hybrid drug carrier system was developed to encapsulate psoralen (PSO), a multidrug resistance reversal agent and traditional Chinese medicine. Emphasis was focused the parameters that influence physicochemical characteristics, and then the drug release profile, stability, cytotoxicity and drug resistance reversal effect of the lipid-polymer hybrid nanoparticles (LPNs) were investigated. It was found that various formulation parameters affected NP size, drug loading (DL) and release characteristics. H...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma.
Authors: Huang J, Huang W, Liu M, Zhu J, Jiang D, Xiong Y, Zhen Y, Yang D, Chen Z, Peng L, Yu Z Abstract SETDB1, an H3K9‑specific histone methyltransferase, has been described as a repressed transcription marker which triggers tumorigenesis of many types of human cancer. However, there are few studies elucidating the relationship between SETDB1 and nasopharyngeal carcinoma. In the present study, we confirmed that SETDB1 exhibited higher expression levels in nasopharyngeal carcinoma (NPC) tissues and cell lines, compared to these levels in non‑tumor tissues and a normal human nasopharyngeal epithelial cell line....
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non ‑small lung cancer cells by regulating the YAP pathway.
Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway. Oncol Rep. 2018 Jun 12;: Authors: Jin D, Wu Y, Shao C, Gao Y, Wang D, Guo J Abstract Non‑small cell lung cancer (NSCLC) accounts for>80% of all lung cancer cases, which are the leading cause of cancer‑related mortality worldwide. The clinical efficacy of available therapies for NSCLC is often limited due to the development of resistance to anticancer drugs, particularly to cisplatin (DDP). Norcantharidin (NCTD) is a traditional Chin...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling.
This study aimed to investigate whether the activation of TLR4 signaling by HSP70 could be inhibited by curcumin, thus investigating the possible mechanism of curcumin in the inhibition of liver cancer. Western blotting was used to evaluate the expression of the HSP70 and TLR4 in HepG2 cells and ELISA was used to detect the concentration of HSP70 in cell culture medium. A thermal tolerance HepG2 (HepG2TT) cell model was established to simulate HSP70 accumulation in the microenvironment. A certain concentration of curcumin was co-cultured with HepG2 and HepG2TT cells to observe the changes of HSP70 and TLR4. Our results rev...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

[Corrigendum] LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells.
Authors: Wei Y, Han T, Wang R, Wei J, Peng K, Lin Q, Shao G Abstract Subsequently to the publication of the article, the authors have realized that the bar chart that accompanied Fig. 4C, indicating the quantification of the western blotting data in this figure part, was published in the absence of either of the axes labels. The authors apologize for this oversight, and a corrected version of Fig. 4, which incorporates the missing labels, is shown opposite. The omission of these axes labels did not have an impact on the overall meaning of the paper. The authors regret that an incomplete version of Fig.&nb...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Alternative splicing variant of RHBDD2 is associated with cell stress response and breast cancer progression.
Authors: Canzoneri R, Rabassa ME, Gurruchaga A, Ferretti V, Palma S, Isla-Larrain M, Croce MV, Lacunza E, Abba MC Abstract RHBDD2 is an intramembrane pseudoprotease member of the Rhomboid superfamily. Our previous studies in breast and colorectal cancer indicate an association between RHBDD2 overexpression and advanced tumor stages. Two alternative transcriptional variants have been described for RHBDD2, which would be encoding for different RHBDD2 protein isoforms. The expression of these RHBDD2 variants/isoforms and its association with breast cancer was the focus of this study. First, expression of RHBDD2 splici...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

γ-tocotrienol inhibits the invasion and migration of human gastric cancer cells through downregulation of cyclooxygenase-2 expression.
γ-tocotrienol inhibits the invasion and migration of human gastric cancer cells through downregulation of cyclooxygenase-2 expression. Oncol Rep. 2018 Jun 14;: Authors: Zhang YH, Ma K, Liu JR, Wang HX, Tian WX, Tu YH, Sun WG Abstract γ-tocotrienol (γ-T3), a tocotrienol isoform belonging to the vitamin E family, has been revealed to exert inhibitory effects on proliferation, migration and invasion in human gastric cancer cells. However, its precise mechanism of action is still unclear and needs to be further tested. Cyclooxygenase-2 (COX-2) is well known for its key role in promot...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of miR-140-5p inhibits lipopolysaccharide-induced human intervertebral disc inflammation and degeneration by downregulating toll-like receptor 4.
In conclusion, the present study may lead to a greater understanding of IVD degeneration and provide new insights into the treatment of this disease. PMID: 29901170 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

DKC1 serves as a potential prognostic biomarker for human clear cell renal cell carcinoma and promotes its proliferation, migration and invasion via the NF ‑κB pathway.
We examined DKC1 protein expression levels in tissue microarrays including 307 cases of ccRCC tissues and in 75 pairs of ccRCC and paracancerous tissues with immunohistochemistry. The percentage of DKC1 expression in ccRCC (61.3%) was markedly higher than that in paracancerous tissues (34.7%) (P=0.001). Positive DKC1 expression tends to significantly be associated with unfavorable clinicopathological characteristics such as tumor diameter>7 cm (P=0.002) and tumor‑node‑metastasis (TNM) stage III or IV (P
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Preliminary mechanisms of regulating PD ‑L1 expression in non‑small cell lung cancer during the EMT process.
Preliminary mechanisms of regulating PD‑L1 expression in non‑small cell lung cancer during the EMT process. Oncol Rep. 2018 Jun 05;: Authors: Li F, Zhu T, Yue Y, Zhu X, Wang J, Liang L Abstract Non‑small cell lung cancer (NSCLC) is one of the most severe malignant tumor types worldwide. Recent studies have reported an important role of PD‑L1 in mediating immune evasion in the tumor microenvironment. In addition, increasing research has indicated that the expression of PD‑L1 is related to the epithelial‑mesenchymal transition (EMT) process, but the related mechanisms remain to be explored. I...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cdc20 inhibitor apcin inhibits the growth and invasion of osteosarcoma cells.
Authors: Gao Y, Zhang B, Wang Y, Shang G Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor worldwide, primarily affecting children and adolescents. The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that is activated by its co‑activator Cdc20 during the metaphase‑anaphase transition. Apcin is a novel cell‑permeable molecule that blocks the interaction between APC/C and Cdc20. Cdc20 overexpression has been reported in various malignancies and plays an oncogenic role in tumorigenesis and tumor progression. In the present study, the antitumor properties of apcin, an i...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer.
Authors: Zhan Y, Zhang H, Dai B, Zhang Y, Zhang J, He L Abstract We recently reported that TPD7 suppressed tumor cell proliferation, and inhibited invasion, through the suppression of C-X-C chemokine receptor type 4 (CXCR4). In the present study, we investigated the anticancer effect of TPD7 on apoptosis and invasion of cervical cancer HeLa cells. Cell cycle analysis revealed that TPD7 decreased cyclin-dependent kinase (CDK)1 and cyclin D1 expression, and increased cyclin A expression, following S phase blockade. TPD7 induced chromatin condensation and significantly elevated the number of apoptotic c...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑150 promotes the proliferation and migration of non‑small cell lung cancer cells by regulating the SIRT2/JMJD2A signaling pathway.
In conclusion, our results demonstrated that miR‑150 plays an important role in the development of lung cancer by serving as an oncogene via the SIRT2/JMJD2A signaling pathway. PMID: 29901178 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Girdin regulates the proliferation and apoptosis of pancreatic cancer cells via the PI3K/Akt signalling pathway.
Authors: Wang S, Lei Y, Cai Z, Ye X, Li L, Luo X, Yu C Abstract Girdin functions as an Akt phosphorylation enhancer (APE), which expedites the proliferation and survival of many types of tumours. However, the influence of Girdin on pancreatic cancer and the underlying molecular mechanisms have yet to be uncovered. Hence, in the present study, we sought to elucidate the function of Girdin in pancreatic cancer malignancy, particularly its role in pancreatic cancer cell proliferation, migration and apoptosis. Immunohistochemistry (IHC) was used to evaluate Girdin expression in pancreatic cancer tissues and to analyse ...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fibroblast growth factor  18 promotes the growth, migration and invasion of MDA‑MB‑231 cells.
Fibroblast growth factor 18 promotes the growth, migration and invasion of MDA‑MB‑231 cells. Oncol Rep. 2018 Jun 07;: Authors: Yu Z, Lou L, Zhao Y Abstract Fibroblast growth factor 18 (FGF18) increases cell motility and invasion in colon tumors, and is linked with ovarian and lung tumors. Furthermore, the increased expression of FGF18 mRNA and protein has been associated with poor overall survival in cancer patients. However, its function has not been investigated in breast cancer. In the present study, we demonstrated that FGF18 promoted cell growth and metastasis in vitro and stimu...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Identification of the potential oncogenes in glioblastoma based on bioinformatic analysis and elucidation of the underlying mechanisms.
Authors: Zhang Y, Xia Q, Lin J Abstract Glioblastoma (GBM) is a common malignant tumour in the human brain, but its molecular mechanisms have not been systematically evaluated. The aim of this study was to identify potential key oncogenes associated with the progression of GBM and to elucidate their mechanisms. The gene expression profile of GSE50161, selected from the Gene Expression Omnibus database, was analysed to find cancer‑associated genes and gene functions in GBM. In total, 486 differentially expressed genes, including 128 upregulated genes, were identified. The function and pathway enrichment of these g...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research